CN1824270A - Middle-jiao regulating medicinal preparation and its new preparation method - Google Patents
Middle-jiao regulating medicinal preparation and its new preparation method Download PDFInfo
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Abstract
A composite Chinese medicine in the form of dripping pill and soft capsule for treating deficiency-cold in spleen and stomach, omiting, diarrhea, abdominalgia and indigestion, and its preparing process are disclosed.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind of Deficiency and coldness of spleen and stomach that is used for, vomiting is had loose bowels, fullness in the chest stomachache, dyspeptic prescription and preparation technology thereof.
Background technology:
Deficiency and coldness of spleen and stomach, vomiting is had loose bowels, fullness in the chest stomachache, dyspepsia is clinical common sympton, and the traditional Chinese medical science is often taked warming spleen and stomach for dispelling cold, and the means that are good for the stomach are treated it, and evident in efficacy, and ball is that it represents medicine in the reason.But in the practice, because this medicine is medical material to be beaten powder be used as medicine in preparation, cause impurity many, shortcoming such as dosage is big has a strong impact on its clinical practice.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, chewable tablet, mixture, its pill that makes can be used for curing mainly Deficiency and coldness of spleen and stomach, vomiting is had loose bowels, fullness in the chest stomachache, dyspepsia.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
37.5～570 parts in 37.5～570 portions of Radix Glycyrrhizaes of 37.5～570 parts of Rhizoma Atractylodis Macrocephalaes of Radix Codonopsis (parching with earth) (processed with honey)
25～380 parts of Rhizoma Zingiberis Preparatums
Preferably:
75 parts in 75 portions of Radix Glycyrrhizaes of 75 parts of Rhizoma Atractylodis Macrocephalaes of Radix Codonopsis (parching with earth) (processed with honey)
50 parts of Rhizoma Zingiberis Preparatums
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls, granule 1000g etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, soft capsule, granule, chewable tablet, mixture.
The above new technology of the present invention may further comprise the steps:
Method a:(technology 1.)
(1) gets the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Preparatum two flavor medical materials, adopt supercritical extraction (or steam distillation): in the supercritical extraction jar of packing into, be that 28MPa, temperature are to extract 3.0～4.0h under 45 ℃, the condition of flow 155～180kg/h with pressure; Get extract; β-CDBao He, optimised process is: β-CD is 1: 6～10 with the water ratio, and oil is 1: 4～6 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
(2) get the residue medical material, decoct with water 2～6 times, each 0.5～3 hour, collecting decoction filtered, and filtrate is condensed into thick paste;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Preparatum two flavor medical materials beats powder and is used as medicine;
(2) the residue medical material is handled the same.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture or other suitable other auxiliary elements of making drop pill, as glycerol, gelatin or stearic acid sodium etc.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2; The content of active component is 50mg～500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation process of granule is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(4) preparation method of hard capsule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, and drying, mixing is filled and is promptly got hard capsule.
Filler described in the preparation of granule, chewable tablet is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
1, to the experiment of rat pyloric ligation ulcer
Get 40 of rats, body weight 160～180g, male and female half and half, female no pregnant, be divided into 4 groups by body weight and male and female.Every day, gastric infusion was 1 time.Technology 1. extractum group is 0.12g/kg; Technology 2. extractum group is 0.47g/kg; The cimetidine group is 0.5g/kg, irritates stomach, and the blank group awards the aquae destillata of equal volume.Each organized successive administration 5 days.The administration back fasting but can't help water that finishes behind the 48h, use the etherization animal, makes the rat pyloric ligation at once, and fasting, taboo water, and the branch cage is put in a suitable place to breed.Take out rat carotid artery blood behind the 16h and put to death, cut open inspection at once, visible rat stomach extreme expansion is full of gastric juice.The taking-up stomach is dirty, cuts off along greater gastric curvature, with the attachment on the scraping blade removal mucosa.And clean with normal saline flushing, flatten on filter paper, visible strip of naked eyes or point-like blood brown canker are with kind of calliper ulcer area.Mark according to ulcer area size, accumulative total is determined the animal ulcer index, the results are shown in Table 1.
Each group of table 1 compares the effect of rat pyloric ligation ulcers ulcer
| Group | n | Dosage (g/kg) | Ulcer inhibition rate (%) |
| Normal saline group cimetidine technology is 2. extractum group of extractum group technology 1. | 10 10 10 10 | - 0.5 0.12 0.47 | 0.00 81.25 *** 72.15 *** 70.21 *** |
Annotate: compare with the blank group,
*P＜0.001,
* *P＜0.001 (down together)
2, to the experiment of the residual influence of mice methyl orange
Get 89 of mices, body weight 22～25g.Be divided into 4 groups by body weight.Behind the fasting 12h, technology 1. extractum group (23 mices) is 0.24g/kg; Technology 2. extractum group (23 mices) is 0.95g/kg, XIANGSHA LIUJU WAN group (23 mices) 10.0g/kg, and blank group (20 mices) gives the distilled water of equal volume.Each organized gastric infusion 5 days.Behind the last administration 40min, taking technique is 2. each 13 of extractum groups, XIANGSHA LIUJU WAN group mice of extractum group, technology 1., 10 of blank group mices, and every 0.1% methyl orange solution of all irritating with 0.2ml, remaining every of each Mus gives distilled water 0.2ml.Behind the 20min, the whole mices of sacrificed by decapitation, it is dirty to take out stomach, cuts off along greater gastric curvature, be dissolved in respectively in the distilled water of 8ml, transfer pH to 6.0～6.5, adding distil water 10ml, centrifugal (2000rpm with the sodium bicarbonate test solution, 10min), get supernatant, measure at the 420nm place with ultraviolet spectrophotometer.Deduct corresponding blank class value (do not give the mice of methyl orange solution, get average) with measured value, the results are shown in Table 2.
Each group of table 2 is to the influence of mice gastric emptying (x ± s) relatively
| Group | Number of animals (only) | Dosage (g/kg) | Methyl orange residual quantity (10 -9g/L) |
| Normal saline group XIANGSHA LIUJU WAN group technology is 2. extractum group of extractum group technology 1. | 10 13 13 13 | - 10.0 0.24 0.95 | 0.877±0.33 1.352±0.39 * 1.571±0.51 *** 1.512±0.39 *** |
Annotate: model group and normal saline group compare,
△ △P＜0.01 administration group and matched group are relatively
*P＜0.05;
*P＜0.01
3, to the mice experiment of analgesic
Get 40 of mices, the male and female dual-purpose is divided into 4 groups at random.Technology 1. extractum group is 0.24g/kg; Technology 2. extractum group is 0.95g/kg, and the blank group gives the distilled water of equal volume.Each organized gastric infusion 5 days.Tramadol hydrochloride 16.7mg/kg, subcutaneous disposable drug administration by injection, behind the last administration 40min, equal lumbar injection 0.6% acetum of each mice (0.2ml/ is only) is observed and is given respectively to organize in the stimulant 15min mouse writhing reaction times, calculate the analgesia percentage rate as follows, the results are shown in Table 3.
Each group of table 3 is to mice analgesic effect (x ± s) relatively
| Group | Number of animals (only) | Dosage (g/kg) | Turn round the body number of times | Analgesia rate (%) |
| Normal saline group tramadol hydrochloride technology is 2. extractum group of extractum group technology 1. | 10 10 10 10 | - 1.67mg/kg 0.24 0.95 | 13.1±6.5 2.3±2.4 *** 3.8±3.2 *** 6.2±3.8 *** | 83.9 71.2 56.6 |
4, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are a kind of good treatment blood deficiency stagnation of QIs, soreness of waist pain, irregular menstruation, leucorrhea with red and white discharge, cold uterus, the medicine of disease such as fail to be impregnated for a long time, and change preparation technology, can obviously strengthen its nourishing YIN and benefiting blood, dispelling cold by warming the meridian, clinical efficacies such as promoting the circulation of QI to relieve pain, its hypotoxicity in addition, therefore prolonged application safety, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
The Radix Codonopsis 190g Rhizoma Atractylodis Macrocephalae (parching with earth) 190g Radix Glycyrrhizae (processed with honey) 190g
Rhizoma Zingiberis Preparatum 126.5g PEG4000 100g
Make 1000 balls
Preparation method:
(1) gets the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Preparatum two flavor medical materials, adopt supercritical extraction (or steam distillation): in the supercritical extraction jar of packing into, be that 28MPa, temperature are to extract 3.0h under 45 ℃, the condition of flow 155～180kg/h with pressure; Get extract; β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 4 with β-CD ratio, and ultrasonic 30min gets clathrate;
(2) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into thick paste;
(3) with above-mentioned extract obtained, the PEG4000 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
The Radix Codonopsis 570g Rhizoma Atractylodis Macrocephalae (parching with earth) 570g Radix Glycyrrhizae (processed with honey) 570g
Rhizoma Zingiberis Preparatum 380g PEG400 300g
Make 1000
Preparation method:
(1) gets the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Preparatum two flavor medical materials, adopt supercritical extraction (or steam distillation): in the supercritical extraction jar of packing into, be that 28MPa, temperature are to extract 3.0h under 45 ℃, the condition of flow 155～180kg/h with pressure; Get extract; β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 4 with β-CD ratio, and ultrasonic 30min gets clathrate;
(2) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into thick paste;
(3) with above-mentioned extract obtained, add an amount of PEG400 and mix and mixing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable is regulated content weight, obtains soft capsule in the soft capsule machine.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
The Radix Codonopsis 375g Rhizoma Atractylodis Macrocephalae (parching with earth) 375g Radix Glycyrrhizae (processed with honey) 375g
Rhizoma Zingiberis Preparatum 250g
Make 1000g
Preparation method:
(1) getting the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Preparatum two flavor medical materials beats powder and is used as medicine;
(2) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into thick paste;
(3) above active component is merged, add aspartame 5.0g, dextrin 240.0g, granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 4:
The preparation method of hard capsule of the present invention:
Prescription:
The Radix Codonopsis 197g Rhizoma Atractylodis Macrocephalae (parching with earth) 197g Radix Glycyrrhizae (processed with honey) 197g
Rhizoma Zingiberis Preparatum 131.5g
Make 1000
Preparation method:
(1) getting the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Preparatum two flavor medical materials beats powder and is used as medicine;
(2) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into thick paste;
(3) above active component is merged, add aspartame 3.0g, mannitol 100.0g, granulation, drying adds magnesium stearate 3.0g, and mixing is filled, and promptly gets 1000 of capsules.
Claims (10)
1, a kind of Chinese medicine preparation is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
37.5～570 parts in 37.5～570 portions of Radix Glycyrrhizaes of 37.5～570 parts of Rhizoma Atractylodis Macrocephalaes of Radix Codonopsis (parching with earth) (processed with honey)
25～380 parts of Rhizoma Zingiberis Preparatums.
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
75 parts in 75 portions of Radix Glycyrrhizaes of 75 parts of Rhizoma Atractylodis Macrocephalaes of Radix Codonopsis (parching with earth) (processed with honey)
50 parts of Rhizoma Zingiberis Preparatums.
3, claim 1 or any one Chinese medicine preparation of 2 are various suitable dosage forms such as drop pill, soft capsule, granule, chewable tablet, mixture, hard capsule.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) gets the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Preparatum two flavor medical materials, adopt supercritical extraction (or steam distillation): in the supercritical extraction jar of packing into, be that 28MPa, temperature are to extract 3.0～4.0h under 45 ℃, the condition of flow 155～180kg/h with pressure; Get extract; β-CDBao He, optimised process is: β-CD is 1: 6～10 with the water ratio, and oil is 1: 4～6 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
(2) get the residue medical material, decoct with water 2～6 times, each 0.5～3 hour, collecting decoction filtered, and filtrate is condensed into thick paste;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Preparatum two flavor medical materials beats powder and is used as medicine;
(2) the residue medical material is handled the same.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that:
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule;
The preparation method of hard capsule is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, mixing is filled and is promptly got hard capsule.
9, the Chinese medicine preparation of claim 8 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1～9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:(technology 1.)
(1) gets the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Preparatum two flavor medical materials, adopt supercritical extraction (or steam distillation): in the supercritical extraction jar of packing into, be that 28MPa, temperature are to extract 3.0～4.0h under 45 ℃, the condition of flow 155～180kg/h with pressure; Get extract; β-CDBao He, optimised process is: β-CD is 1: 6～10 with the water ratio, and oil is 1: 4～6 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
(2) get the residue medical material, decoct with water 2～6 times, each 0.5～3 hour, collecting decoction filtered, and filtrate is condensed into thick paste;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Preparatum two flavor medical materials beats powder and is used as medicine;
(2) the residue medical material is handled the same.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: active constituents of medicine is mixed with proper auxiliary materials, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510134410 CN1824270A (en) | 2005-12-15 | 2005-12-15 | Middle-jiao regulating medicinal preparation and its new preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510134410 CN1824270A (en) | 2005-12-15 | 2005-12-15 | Middle-jiao regulating medicinal preparation and its new preparation method |
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ID=36935215
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105497877A (en) * | 2015-12-31 | 2016-04-20 | 中悦民安（北京）科技发展有限公司 | Traditional Chinese medicine composition for livestock and poultry and fish for invigorating spleen and stopping diarrhea |
| CN107802811A (en) * | 2017-11-22 | 2018-03-16 | 董靖 | A kind of gut purge pellet for curing diarrhea |
| CN110038049A (en) * | 2019-05-20 | 2019-07-23 | 石红雨 | A kind of plaster that treating rotavirus enteritis and preparation method |
-
2005
- 2005-12-15 CN CN 200510134410 patent/CN1824270A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105497877A (en) * | 2015-12-31 | 2016-04-20 | 中悦民安（北京）科技发展有限公司 | Traditional Chinese medicine composition for livestock and poultry and fish for invigorating spleen and stopping diarrhea |
| CN107802811A (en) * | 2017-11-22 | 2018-03-16 | 董靖 | A kind of gut purge pellet for curing diarrhea |
| CN110038049A (en) * | 2019-05-20 | 2019-07-23 | 石红雨 | A kind of plaster that treating rotavirus enteritis and preparation method |
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