CN1748748A - Little leaf deervetch herb preparation for pregnant woman and new preparing method - Google Patents
Little leaf deervetch herb preparation for pregnant woman and new preparing method Download PDFInfo
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- CN1748748A CN1748748A CNA2005101091969A CN200510109196A CN1748748A CN 1748748 A CN1748748 A CN 1748748A CN A2005101091969 A CNA2005101091969 A CN A2005101091969A CN 200510109196 A CN200510109196 A CN 200510109196A CN 1748748 A CN1748748 A CN 1748748A
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Abstract
The present invention relates to a Chinese medicine composition, and especially a kind of Chinese medicine composition for treating pregnant woman's headache, dizziness, nasal and oral sore, swelling and aching throat, red and swelling eyes, toothache, lower abdomen pain, etc. and its preparation process. The Chinese medicine composition is preferably prepared into dripping pill and soft capsule.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind of treatment anemia of pregnant woman headache, dizzy, mouth and nose are given birth to skin ulcer, laryngopharynx swelling and pain, binocular is red swollen, gingiva pain, or fetal movement tenesmus, lower abdomen is had a pain, vexed uneasiness, dry mouth and throat, thirst and desire for cold drink, the prescription of diseases such as oliguria with yellow urine and preparation technology thereof.
Background technology:
Anemia of pregnant woman's headache, dizzy, mouth and nose are given birth to skin ulcer, laryngopharynx swelling and pain, binocular is red swollen, gingiva pain, or the fetal movement tenesmus, lower abdomen is had a pain, vexed uneasiness, dry mouth and throat, thirst and desire for cold drink, diseases such as oliguria with yellow urine are clinical common symptons, the traditional Chinese medical science is often taked heat clearing away, antiabortive means are treated it, and evident in efficacy, and Yunfu Jinhua Wan is that it represents medicine.But in the practice, because this medicine is medical material to be beaten powder be used as medicine in preparation, cause impurity many, shortcoming such as dosage is big has a strong impact on its clinical practice.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, chewable tablet, capsule, tablet, its pill that makes can be used for curing mainly anemia of pregnant woman's headache, and is dizzy, mouth and nose are given birth to skin ulcer, laryngopharynx swelling and pain, binocular is red swollen, gingiva pain, or fetal movement tenesmus, lower abdomen is had a pain, vexed uneasiness, dry mouth and throat, thirst and desire for cold drink, diseases such as oliguria with yellow urine.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
30～473 parts of 30～473 parts of Radix Angelicae Sinensis of 30～473 portions of Flos Loniceraes of Fructus Gardeniae (processed with Rhizoma Zingiberis Recens)
30～473 parts of 30～473 portions of Radix Rehmanniae of 30～473 parts of Rhizoma Chuanxiongs of the Radix Paeoniae Alba
15～237 parts of 30～473 portions of Rhizoma Coptidis of 30～473 portions of Cortex Phellodendris of Radix Scutellariae
Preferably:
60 parts of 60 parts of Radix Angelicae Sinensis of 60 portions of Flos Loniceraes of Fructus Gardeniae (processed with Rhizoma Zingiberis Recens)
60 parts of 60 portions of Radix Rehmanniae of 60 parts of Rhizoma Chuanxiongs of the Radix Paeoniae Alba
30 parts of 60 portions of Rhizoma Coptidis of 60 portions of Cortex Phellodendris of Radix Scutellariae
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls, granule 1000g etc. also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, soft capsule, granule, chewable tablet, tablet, capsule.
The above new technology of the present invention may further comprise the steps:
Method a:
(1) get Radix Angelicae Sinensis, Rhizoma Chuanxiong, adopt supercritical extraction (or steam distillation), extraction kettle pressure is 25MPa, and the pressure of extraction-container I is 8MPa, and the pressure of extraction-container II is 6MPa; CO
2Flow is about 18kg/h, and extraction 4h gets extract; Optimised process is: β-CD is 1: 6～10 with the water ratio, and oil is 1: 4～6 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
(2) get the residue medical material, soaked 30～60 minutes earlier with 50～85% ethanol, reheat reflux, extract, three times, each 0.5～2 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) alcohol extract and volatile oil clathrate compound lump together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:
(1) get medical material except that Radix Angelicae Sinensis, Rhizoma Chuanxiong, with 6～15 times water extraction 2～4 times, each 0.5～2.5 hour, merge extractive liquid, filtered, and the extractum of reclaim under reduced pressure is standby;
(2) extraction of all the other medical materials is with method a;
(3) volatile oil clathrate compound and water extract are lumped together active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture, or other suitable other auxiliary elements of making drop pill, as glycerol, gelatin or stearic acid sodium etc.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2.Wherein the weight proportion between active component and the pharmaceutically useful organic solvent is: the content of active component is 50mg-500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation process of granule is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(4) preparation method of chewable tablet is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, and drying, tabletting promptly gets chewable tablet.
Filler described in granule, capsule, pill, the chewable tablet preparation is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
1, to the influence of rabbit anus temperature due to the TAB/VAC
Get 16 of body weight 2.0～2.5kg rabbit, the male and female dual-purpose is divided equally 4 groups (n=4) at random.Survey 3 anus temperature continuously, each 3min, 1h at interval; 3 results are got its meansigma methods as basal body temperature,, gavage administration when treating 0.5 ℃ of anus temperature rise then by auricular vein injection TAB/VAC 1ml/kg.Technology is extractum group (0.078g/kg) 1., and technology 2. extractum group (0.1g/kg) positive controls gavages aspirin 0.1g/kg, and matched group gavages the equal-volume distilled water.After the test administration 1,2,3, the anus temperature of each treated animal of 4h, the significance with t value method check medicine group and matched group effect the results are shown in Table 1.
The influence of rabbit anus temperature due to the table 1 pair TAB/VAC (℃, x ± s)
| Group | Basal body temperature | Anus temperature after the pyrogenicity | Anus temperature after the administration | |||
| 0.5h | 1h | 2h | 3h | |||
| Matched group technology is 2. extractum group aspirin of extractum group technology 1. | 39.55±0.16 39.36±0.17 39.51±0.19 39.35±0.14 | 40.80±0.29 40.63±0.35 40.80±0.28 40.48±0.34 | 41.13±0.30 40.35±0.55 * 41.10±0.38 40.13±0.22 ** | 41.20±0.14 40.03±0.18 * 40.43±0.42 40.05±0.21 ** | 40.88±0.29 39.76±0.54 ** 39.83±0.20 ** 39.78±0.13 ** | 40.60±0.22 39.43±0.31 ** 39.75±0.17 ** 39.50±0.08 ** |
Annotate: compare with matched group,
*P＜0.05;
*P＜0.01
2, to 2, the influence of 2, 4-dinitrophenol pyrogenicity rat
Get 48 of body weight 180-230g rats, the male and female dual-purpose is tested the anus temperature every day 1 time (anus thermometre insertion depth 3cm), continuously 3d.Get the variation of anus temperature and be no more than 0.5 ℃ rat, be divided into 4 groups (n=12) at random.Technology is extractum group (0.16g/kg) 1., and technology 2. extractum group (0.2g/kg) positive controls gavages aspirin 0.1g/kg; Matched group gavages the equal-volume distilled water.The every Mus of 1h back subcutaneous injection 2 after administration, 2, 4-dinitrophenol 20mg/kg per hour tests rat anus temperature 1 time then, and follow-on test 4h is with the significance of t value method check medicine group and matched group effect.
Table 2 pairs 2, the influence of 2, 4-dinitrophenol pyrogenicity rat (℃, x ± s)
| Group | Basal body temperature | Anus temperature after the pyrogenicity | Anus temperature after the administration | |||
| 0.5h | 1h | 2h | 3h | |||
| Matched group technology is 2. extractum group aspirin of extractum group technology 1. | 37.82±0.44 37.66±0.41 37.94±0.57 37.94±0.42 | 39.12±0.64 39.14±0.36 38.99±0.71 38.54±0.41 | 39.90±0.71 38.98±0.62 ** 39.30±0.68 38.37±0.22 ** | 40.27±0.14 38.69±0.18 ** 39.00±0.42 * 38.15±0.21 ** | 40.30±0.84 38.59±0.34 * 38.68±0.69 ** 38.19±0.28 ** | 39.60±0.99 38.14±0.74 ** 38.40±0.46 ** 38.67±0.27 ** |
Annotate: compare with matched group,
*P＜0.05;
*P＜0.01
3, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are a kind of good treatment anemia of pregnant woman headache, and be dizzy, mouth and nose are given birth to skin ulcer, laryngopharynx swelling and pain, and binocular is red swollen, gingiva pain, or the fetal movement tenesmus, lower abdomen is had a pain, vexed uneasiness, dry mouth and throat, thirst and desire for cold drink, the medicine of diseases such as oliguria with yellow urine, and change preparation technology, can obviously strengthen its heat clearing away, antiabortive clinical efficacy, its hypotoxicity in addition of waiting, therefore prolonged application safety, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Fructus Gardeniae (processed with Rhizoma Zingiberis Recens) 93g Flos Lonicerae 93g Radix Angelicae Sinensis 93g
Radix Paeoniae Alba 93g Rhizoma Chuanxiong 93g Radix Rehmanniae 93g
Radix Scutellariae 93g Cortex Phellodendri 93g Rhizoma Coptidis 46g
PEG400100g
Make 1000 balls
Preparation method:
(1) get Radix Angelicae Sinensis, Rhizoma Chuanxiong, adopt supercritical extraction (or steam distillation), extraction kettle pressure is 25MPa, and the pressure of extraction-container I is 8MPa, and the pressure of extraction-container II is 6MPa; CO
2Flow is about 18kg/h, and extraction 4h gets extract; β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, oil is 1: 5 with β-CD ratio, ultrasonic 50min;
(2) get the residue medical material, soaked 40 minutes earlier with 80% ethanol, reheat reflux, extract, three times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) with above-mentioned extract obtained, the PEG400 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Fructus Gardeniae (processed with Rhizoma Zingiberis Recens) 372g Flos Lonicerae 372g Radix Angelicae Sinensis 372g
Radix Paeoniae Alba 372g Rhizoma Chuanxiong 372g Radix Rehmanniae 372g
Radix Scutellariae 372g Cortex Phellodendri 372g Rhizoma Coptidis 186g
PEG400200g
Make 1000
Preparation method:
(1) get Radix Angelicae Sinensis, Rhizoma Chuanxiong, adopt supercritical extraction (or steam distillation), extraction kettle pressure is 25MPa, and the pressure of extraction-container I is 8MPa, and the pressure of extraction-container II is 6MPa; CO
2Flow is about 18kg/h, and extraction 4h gets extract; β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, oil is 1: 5 with β-CD ratio, ultrasonic 50min;
(2) get the residue medical material, soaked 40 minutes earlier with 80% ethanol, reheat reflux, extract, three times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) with above-mentioned extract obtained, add an amount of PEG400 and mix and mixing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable is regulated content weight, obtains soft capsule in the soft capsule machine.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
Fructus Gardeniae (processed with Rhizoma Zingiberis Recens) 473g Flos Lonicerae 473g Radix Angelicae Sinensis 473g
Radix Paeoniae Alba 473g Rhizoma Chuanxiong 473g Radix Rehmanniae 473g
Radix Scutellariae 473g Cortex Phellodendri 473g Rhizoma Coptidis 237g
Make 1000g
Preparation method:
(1) get Radix Angelicae Sinensis, Rhizoma Chuanxiong, adopt supercritical extraction (or steam distillation), extraction kettle pressure is 25MPa, and the pressure of extraction-container I is 8MPa, and the pressure of extraction-container II is 6MPa; CO
2Flow is about 18kg/h, and extraction 4h gets extract; β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, oil is 1: 5 with β-CD ratio, ultrasonic 50min;
(2) get the residue medical material, with 10 times water extraction 3 times, each 1.5 hours, merge extractive liquid, filtered, and the extractum of reclaim under reduced pressure is standby;
(3) merge the said extracted thing, add aspartame 5.0g, dextrin 250.0g, granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 4:
The preparation method of chewable tablet of the present invention:
Prescription:
Fructus Gardeniae (processed with Rhizoma Zingiberis Recens) 196g Flos Lonicerae 196g Radix Angelicae Sinensis 196g
Radix Paeoniae Alba 196g Rhizoma Chuanxiong 196g Radix Rehmanniae 196g
Radix Scutellariae 196g Cortex Phellodendri 196g Rhizoma Coptidis 98g
Make 1000
Preparation method:
(1) get Radix Angelicae Sinensis, Rhizoma Chuanxiong, adopt supercritical extraction (or steam distillation), extraction kettle pressure is 25MPa, and the pressure of extraction-container I is 8MPa, and the pressure of extraction-container II is 6MPa; CO
2Flow is about 18kg/h, and extraction 4h gets extract; β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, oil is 1: 5 with β-CD ratio, ultrasonic 50min;
(2) get the residue medical material, with 10 times water extraction 3 times, each 1.5 hours, merge extractive liquid, filtered, and the extractum of reclaim under reduced pressure is standby;
(3) merge the said extracted thing, add aspartame 3.0g, mannitol 200.0g, granulation, drying adds magnesium stearate 3.0g, mixing, and tabletting promptly gets 1000 of chewable tablet.
Claims (10)
1, a kind of Chinese medicine preparation is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
30～473 parts of 30～473 parts of Radix Angelicae Sinensis of 30～～473 portions of Flos Loniceraes of Fructus Gardeniae (processed with Rhizoma Zingiberis Recens)
30～473 parts of 30～473 portions of Radix Rehmanniae of 30～473 parts of Rhizoma Chuanxiongs of the Radix Paeoniae Alba
15～237 parts of 30～473 portions of Rhizoma Coptidis of 30～473 portions of Cortex Phellodendris of Radix Scutellariae
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
60 parts of 60 parts of Radix Angelicae Sinensis of 60 portions of Flos Loniceraes of Fructus Gardeniae (processed with Rhizoma Zingiberis Recens)
60 parts of 60 portions of Radix Rehmanniae of 60 parts of Rhizoma Chuanxiongs of the Radix Paeoniae Alba
30 parts of 60 portions of Rhizoma Coptidis of 60 portions of Cortex Phellodendris of Radix Scutellariae
3, claim 1 or any one Chinese medicine preparation of 2 are drop pill, soft capsule, granule, chewable tablet, tablet, capsule.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) get Radix Angelicae Sinensis, Rhizoma Chuanxiong, adopt supercritical extraction (or steam distillation), extraction kettle pressure is 25MPa, and the pressure of extraction-container I is 8MPa, and the pressure of extraction-container II is 6MPa; CO
2Flow is about 18kg/h, and extraction 4h gets extract; β-CDBao He, optimised process is: β-CD is 1: 6～10 with the water ratio, and oil is 1: 4～6 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
(2) get the residue medical material, soaked 30～60 minutes earlier with 50～85% ethanol, reheat reflux, extract, three times, each 0.5～2 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) alcohol extract and volatile oil clathrate compound lump together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get medical material except that Radix Angelicae Sinensis, Rhizoma Chuanxiong, with 6～15 times water extraction 2～4 times, each 0.5～2.5 hour, merge extractive liquid, filtered, and the extractum of reclaim under reduced pressure is standby;
(2) extraction of all the other medical materials is with method a;
(3) volatile oil clathrate compound and water extract are lumped together active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that:
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule;
The preparation method of chewable tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
9, the Chinese medicine preparation of claim 8 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1～9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:
(1) get Radix Angelicae Sinensis, Rhizoma Chuanxiong, adopt supercritical extraction (or steam distillation), extraction kettle pressure is 25MPa, and the pressure of extraction-container I is 8MPa, and the pressure of extraction-container II is 6MPa; CO
2Flow is about 18kg/h, and extraction 4h gets extract; β-CDBao He, optimised process is: β-CD is 1: 6～10 with the water ratio, and oil is 1: 4～6 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
(2) get the residue medical material, soaked 30～60 minutes earlier with 50～85% ethanol, reheat reflux, extract, three times, each 0.5～2 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) alcohol extract and volatile oil clathrate compound lump together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:
(1) get medical material except that Radix Angelicae Sinensis, Rhizoma Chuanxiong, with 6～15 times water extraction 2～4 times, each 0.5～2.5 hour, merge extractive liquid, filtered, and the extractum of reclaim under reduced pressure is standby;
(2) extraction of all the other medical materials is with method a;
(3) volatile oil clathrate compound and water extract are lumped together active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule;
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005101091969A CN1748748A (en) | 2005-10-20 | 2005-10-20 | Little leaf deervetch herb preparation for pregnant woman and new preparing method |
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|---|---|---|---|
| CNA2005101091969A CN1748748A (en) | 2005-10-20 | 2005-10-20 | Little leaf deervetch herb preparation for pregnant woman and new preparing method |
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| CN1748748A true CN1748748A (en) | 2006-03-22 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101836591A (en) * | 2010-06-03 | 2010-09-22 | 中国农业大学 | Method for culturing axillary bud tissue of strawberry |
| CN102228552A (en) * | 2011-05-26 | 2011-11-02 | 刘永俊 | Chinese medicinal composition for treating childbed infection and preparation method thereof |
| CN102327377A (en) * | 2011-09-23 | 2012-01-25 | 深圳市嘉轩医药科技发展有限公司 | Traditional Chinese medicine composition for treating functional dyspepsia |
| CN103393182A (en) * | 2013-07-31 | 2013-11-20 | 马健 | Health-care fruit oral liquid for pregnant women |
| CN105998306A (en) * | 2016-07-25 | 2016-10-12 | 广东温氏大华农生物科技有限公司 | Detoxifying traditional Chinese medicine composition for animals and preparation method thereof |
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2005
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101836591A (en) * | 2010-06-03 | 2010-09-22 | 中国农业大学 | Method for culturing axillary bud tissue of strawberry |
| CN102228552A (en) * | 2011-05-26 | 2011-11-02 | 刘永俊 | Chinese medicinal composition for treating childbed infection and preparation method thereof |
| CN102228552B (en) * | 2011-05-26 | 2012-07-25 | 刘永俊 | Chinese medicinal composition for treating childbed infection and preparation method thereof |
| CN102327377A (en) * | 2011-09-23 | 2012-01-25 | 深圳市嘉轩医药科技发展有限公司 | Traditional Chinese medicine composition for treating functional dyspepsia |
| CN102327377B (en) * | 2011-09-23 | 2013-07-24 | 深圳市嘉轩医药科技发展有限公司 | Traditional Chinese medicine composition for treating functional dyspepsia |
| CN103393182A (en) * | 2013-07-31 | 2013-11-20 | 马健 | Health-care fruit oral liquid for pregnant women |
| CN105998306A (en) * | 2016-07-25 | 2016-10-12 | 广东温氏大华农生物科技有限公司 | Detoxifying traditional Chinese medicine composition for animals and preparation method thereof |
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