CN101708275B - Chinese medicament for treating flu caused by influenza A(H1N1) and the like - Google Patents
Chinese medicament for treating flu caused by influenza A(H1N1) and the like Download PDFInfo
- Publication number
- CN101708275B CN101708275B CN2009102501386A CN200910250138A CN101708275B CN 101708275 B CN101708275 B CN 101708275B CN 2009102501386 A CN2009102501386 A CN 2009102501386A CN 200910250138 A CN200910250138 A CN 200910250138A CN 101708275 B CN101708275 B CN 101708275B
- Authority
- CN
- China
- Prior art keywords
- parts
- influenza
- chinese medicine
- herba
- processed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Medicines Containing Plant Substances (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
Abstract
The invention discloses a Chinese medicament for treating the flu caused by influenza A(H1N1) and the like, which belongs to the technical field of Chinese medicament. The Chinese medicament is prepared from the following raw material medicaments: mix-fried ephedra herb, gypsum, honeysuckle flower, weeping forsythiae capsule, baical skullcap root, common anemarrhena rhizome, thunberg fritillary bulb, toasted almond, great burdock achene, sweet wormwood herb, peppermint, and raw licorice root. The Chinese medicament of the invention not only can have obvious healing effect on classical symptoms of the flu, such as fever, discomfort or soreness of the throat, cough and the like, has broad spectrum antibacterial effect, and is convenient for purchasing, decoction and administration because the raw medicinal materials are all common medicinal materials.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate in particular to Chinese medicine and the Chinese medicinal tablet and the granule technical field of the influenza that a kind of treatment causes by influenza virus such as H1N1s.
Background technology
Influenza (influenza is called for short influenza) is the ARI that influenza virus causes, also is the disease that a kind of infectiousness is strong, spread speed is fast.Its mainly through the airborne spittle, interpersonal contact or with the contact transmission of contaminated article.Typical clinical symptoms is: anxious hyperpyrexia, whole body pain, the remarkable weak and slight respiratory symptom of rising.General autumn and winter season is its high-incidence season, and the caused complication and the phenomena of mortality are very serious.
Influenza virus can be divided into first (A), second (B), third (C), three types, and antigenic variation often takes place first type virus, and infectiousness is big, propagates rapidly, and easy generation is popular on a large scale.
Influenza A H1N1 is called A (H1N1) type influenza again; Be once called as people infected pigs influenza; Influenza A H1N1 influenza virus is an A type influenza virus; Carry H1N1 hypotype swine influenza virus strain, include ribonucleic acid (RNA) gene segment of North America and Eurasian swine flue, bird flu and three kinds of influenza virus of human influenza, have Asia swine flue and African swine influenza virus characteristic simultaneously.
The early symptom of influenza A H1N1 clinical manifestation is similar with ordinary people's influenza; Comprise heating, cough, laryngalgia, physical distress, headache, heating etc.; Some also can occur diarrhoea or vomiting, myalgia or tired, eyes are rubescent etc.; The part conditions of patients can make progress rapidly; Break with tremendous force, suddenly hyperpyrexia, body temperature surpass 39 ℃, even the serious pneumonia of secondary, acute respiratory distress syndrome, pneumorrhagia, hydrothorax, pancytopenia, renal failure, septicemia, shock and Reye syndrome, respiratory failure and multiple organ injury cause death.The original underlying diseases of patient also can increase the weight of.
At present the patient to influenza generally uses antiviral drugs to treat, though the order of severity that these medicines can palliate a disease and improve chance for survival, expense is too high and because life-time service has caused some virus to produce drug resistance.
Summary of the invention
Think on the Chinese medicine to be influenza " exopathogen invasion ",, therefore be called " exopathogen " no matter, all belong to beyond the internal organs because viral cradle is nasal mucosa or respiratory tract.The traditional Chinese medical science is roughly divided " anemofrigid cold " and " anemopyretic cold " by the table note of the ancient Chinese and the somatic reaction classification of disease.Anemopyretic cold symptom: have sore throat, have a fever, have no appetite, rhinorrhea (dense thick, yellow green), thick sputum arranged.
2009 influenza A H1N1 belong to " epidemic febrile disease " category on Chinese medicine, what cause because of affection due to external wind and heat poison heresy is the clinical New Development infectious disease of characteristic with heating, throat discomfort or pain, cough, and the core pathogenesis of light disease is " the evil invasion and attack of wind heat poison lung is defended ".
The inventor is based on the Epidemic Febrile Disease opinion of studying the science, and the collection famous epidemic febrile disease scholar's in Beijing clinical experience integrates classical name side MAXINGSHIGAN TANG, Lonicerae and Forsythiae Powder, Baihu Tang, has invented and has treated the Chinese medicine and the dosage form thereof of influenza, thereby accomplished the present invention.
Because influenza virus produces drug resistance to some Western medicine; So some antiviral drugs can't be carried out the wide spectrum efficacious therapy to cold virus; The objective of the invention is in order to address the above problem, performance Chinese medicine traditional advantage provides Chinese medicine and the Chinese medicinal tablet and the granule of the influenza that a kind of treatment comprises influenza A H1N1; Set about from initiatively removing body endogenous wind pathogenic heat poison aspect, improve the human body resistance against diseases.
Technical scheme of the present invention is following:
A kind of Chinese medicine of treating influenza; Wherein said Chinese medicine is processed by following bulk drugs, and said crude drug comprises 10～30 parts of 3～9 parts of Herba Ephedrae (processed), 30～90 parts of Gypsum Fibrosum, 10～30 parts of Flos Loniceraes, 10～30 parts of Fructus Forsythiaes, 15～30 parts of Radix Scutellariaes, 6～20 parts of the Rhizoma Anemarrhenaes and Herba Artemisiae Annuaes.
Chinese medicine described in the technique scheme, the weight portion of wherein said each composition be 6 parts of Herba Ephedrae (processed), 30 parts of Gypsum Fibrosum, 15 parts of Flos Loniceraes, 15 parts of Fructus Forsythiaes, 15 parts of Radix Scutellariaes, 10 parts of the Rhizoma Anemarrhenaes and 15 parts of Herba Artemisiae Annuaes.
Chinese medicine described in the technique scheme, wherein said crude drug also comprise 6～20 parts of Bulbus Fritillariae Thunbergiis, 3～10 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 10～20 parts of Fructus Arctiis, 3～10 parts of Herba Menthaes.
Chinese medicine described in the technique scheme, the weight portion of wherein said each composition are 6 parts of 6 parts of Herba Ephedrae (processed), 30 parts of Gypsum Fibrosum, 15 parts of Flos Loniceraes, 15 parts of Fructus Forsythiaes, 15 parts of Radix Scutellariaes, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Bulbus Fritillariae Thunbergiis, 9 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 15 parts of Fructus Arctiis and Herba Menthaes.
Chinese medicine described in the technique scheme, wherein said crude drug also comprise 3～10 parts of Radix Glycyrrhizae.
Chinese medicine described in the technique scheme, the weight proportion of wherein said each composition are 6 parts of Herba Ephedrae (processed), 30 parts of Gypsum Fibrosum, 15 parts of Flos Loniceraes, 15 parts of Fructus Forsythiaes, 15 parts of Radix Scutellariaes, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Bulbus Fritillariae Thunbergiis, 9 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 15 parts of Fructus Arctiis, 15 parts of Herba Artemisiae Annuaes, 6 parts of Herba Menthaes, 10 parts of Radix Glycyrrhizae.
The preparation method of Chinese medicine of this treatment influenza is with described Chinese medicinal components decocting, or the pulverize immersion is quoted; Or other conventional method of Chinese medicine;
The purposes of the Chinese medicine of the influenza that this treatment is caused by influenza virus such as H1N1s is the purposes of preparation treatment cold medicine;
This flu is the flu that is caused by virus;
The purposes of the Chinese medicine of the influenza that this treatment is caused by influenza virus such as H1N1s is the medicine of preparation treatment cold, fever symptom.。
Chinese medicine of the present invention can also adopt the conventional method of Chinese medicine preparation to be prepared into any other conventional oral preparations, and the Chinese medicine in Chinese medicinal tablet and the capsule and the ratio of carrier can be used conventional weight ratio.
Herba Ephedrae (processed) is warm in nature in the above-mentioned raw materials medicine, and acrid in the mouth, little hardship have the effect of diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema; Gypsum Fibrosum property Great Cold, acrid in the mouth, sweet, the effect that has clearing away heat-fire, relieving restlessness to quench the thirst; Flos Lonicerae sweet in the mouth cold in nature has heat-clearing and toxic substances removing, cool effect of loosing; Fructus Forsythiae cold nature bitter in the mouth has the effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Rhizoma Anemarrhenae nature and flavor bitter cold has clearing away heat-fire, the effect of promoting the production of body fluid and moisturizing; Radix Scutellariae nature and flavor bitter cold has heat clearing and damp drying, the effect of eliminating fire and detoxication, and Herba Artemisiae Annuae is cold in nature, and bitter in the mouth, suffering have clearing away summer-heat, remove and steam, the effect of preventing the attack (or recurrence) of malaria; Herba Ephedrae (processed) dispelling wind to relieve the exterior syndrome, Gypsum Fibrosum heat clearing away expelling pathogenic factors from muscles are defended to the evil invasion and attack of poison lung and to be monarch drug; Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Herba Artemisiae Annuae and the Rhizoma Anemarrhenae have heat-clearing and toxic substances removing, strengthen the power of heat clearing away, increase the effect of the property of detoxifcation, is this side's ministerial drug;
Stir-baked SEMEN ARMENIACAE AMARUM slightly warm in nature bitter in the mouth has the effect of sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation; Bulbus Fritillariae Thunbergii nature and flavor bitter cold has the effect of heat clearing away eliminating stagnation, preventing phlegm from forming and stopping coughing; Fructus Arctii is cold in nature, and acrid in the mouth, hardship have the effect of evacuation, lung qi dispersing rash, resolving toxin and disinhibiting the throat; Add cool in nature, the acrid in the mouth of Herba Menthae, dispelling wind is arranged, dispel the heat, ward off dirty, antidotal effect; Adding Bulbus Fritillariae Thunbergii, stir-baked SEMEN ARMENIACAE AMARUM have the effect of preventing phlegm from forming and stopping coughing, and Fructus Arctii, Herba Menthae have the adjuvant drug that act as of expelling pathogenic factors from the exterior sore-throat relieving;
Radix Glycyrrhizae property is put down sweet in the mouth, and the effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription is arranged; Add the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription; Making the efficacy of a drug stay in the part of the body cavity above the diaphragm housing the heart and lungs is messenger drug; This classical name side of side's collection MAXINGSHIGAN TANG, Lonicerae and Forsythiae Powder, Baihu Tang are one, have dispelling wind and heat pathogens, the effect of heat-clearing and toxic substances removing; It is red red etc. that the evil invasion and attack of treatment wind heat poison lung is defended heating, throat discomfort or the pain, cough, the throat that cause, is used for upper respiratory tract infection that influenza A H1N1 and other virus causes and has the invasion and attack lung and defend card.
Chinese medicine of the present invention and Chinese medicinal tablet and granule have following beneficial effect:
1, the crude drug that the present invention adopted all is common medical materials, and the patient can buy and decoction very easily;
2,, bring financial burden therefore can for patient's treatment, thereby remove patient's trouble and worry from because selected Chinese crude drug all is common medical materials;
3, Chinese medicine of the present invention can have tangible curative effect to classical symptom such as heating, throat discomfort or pain, the cough etc. of the influenza that comprises influenza A H1N1;
4, because the characteristic of the broad-spectrum antiseptic of Chinese medicine can efficacious therapy have the caused influenza of chemical sproof virus to antiviral drugs such as oseltamivir phosphate capsule.
Below further specify the beneficial effect that the present invention has through Test Example, these Test Example have comprised the clinical observation on the therapeutic effect test of Chinese medicine extract of the present invention.
Test Example 1: medicine of the present invention and oseltamivir phosphate capsule are in the contrast of treatment influenza A H1N1
1, patient's alternative condition:
394 patients of examination, all patients all meet (1), meet the diagnostic criteria that Ministry of Public Health is formulated, (2), 14-70 the year, (3), disease time (heating occurring, axillaty temperature>=37.5 ℃ companion's pharyngalgia, cough symptom)≤72 hours
Exclusion standard: (1), gestation, (2), pneumonia, sick, the immunodeficiency in serious basis, (3), take antiviral agents before going into group, (4), have organ function depleted
2, group:
Blank group, oseltamivir phosphate capsule (Oseltamivir) group, drug group of the present invention (to call Chinese drug-treated group in the following text) and (oseltamivir phosphate capsule+Chinese medicine) group are set respectively, and wherein the oseltamivir phosphate capsule group is taken and is taken three nights one of Chinese medicine 200ml daytime at three nights one of oseltamivir phosphate capsule 75mg Bid daytime, Chinese drug-treated group, (oseltamivir phosphate capsule+Chinese medicine) is organized and taken (oseltamivir phosphate capsule 75mg Bi d+ Chinese medicine 200ml) three nights one of daytime
3, demographic characteristics: (n=394)
4, Clinical symptoms: (n=394)
| Blank control group | The oseltamivir phosphate capsule group | Chinese drug-treated group | Oseltamivir phosphate capsule Combined with Chinese Herbal group | P | |
| High fever | 0.673 | ||||
| ≤38℃ | 21 | 24 | 28 | 24 | |
| 38.1-39℃ | 50 | 50 | 60 | 53 | |
| ≥39℃ | 21 | 24 | 15 | 24 | |
| Cough | 72 | 72 | 78 | 72 | 0.712 |
| Pharyngalgia | 54 | 43 | 66 | 63 | 0.016 |
| Headache | 39 | 45 | 45 | 46 | 0.957 |
| Rhinorrhea | 24 | 24 | 19 | 23 | 0.608 |
| Nasal obstruction | 17 | 15 | 15 | 22 | 0.515 |
| Expectoration | 26 | 16 | 18 | 14 | 0.665 |
5, MAIN OUTCOME MEASURES assessment:
6, less important observation index:
| Index | Blank control group | The oseltamivir phosphate capsule group | Chinese drug-treated group | Oseltamivir phosphate capsule Combined with Chinese Herbal group | P |
| Dispensing-remission time (hr) | |||||
| Cough | 4 | 4 | 4 | 4 | 0.217 |
| Pharyngalgia | 2 | 2 | 3 | 3 | 0.258 |
| Expectoration | 3 | 3 | 3 | 3 | 0.754 |
| Rhinorrhea | 3 | 1 | 2 | 1.5 | 0.367 |
| Headache | 2 | 1 | 2 | 1 | 0.153 |
| Nasal obstruction | 2 | 2 | 2 | 2 | 0.540 |
| Muscular soreness | 1 | 1 | 1 | 1 | 0.945 |
| Weak | 2 | 1 | 2 | 2 | 0.945 |
7, complication, complication, antibiotic:
8, length of stay:
Oseltamivir phosphate capsule group and combined group be P=0.041 relatively; Compare all＞0.05 between other each groups
9, pharmacoeconomics:
10, drug compliance:
All more satisfactory wherein 2 examples of compliance go into to organize to treat left hospital in 3 days (Chinese drug-treated group and drug combination group be 1 example respectively), and 3 examples are gone into group and treated left hospital in 4 days (blank, oseltamivir phosphate capsule and drug combination group be 1 example respectively).
11, drug safety:
Chinese drug-treated group 1 example is felt sick, is vomitted, and can not tolerate the premature termination test.
12, preliminary study result:
(1), three treatment groups effect of bringing down a fever all significantly is superior to blank control group;
(2), Chinese medicine is compared with Ao Sitawei: curative effect is similar, and the medicine expense is few;
(3), therapeutic alliance group does not show advantage.
Test Example 2:Medicine of the present invention causes the influence of fever in rabbit body temperature to endotoxin
1, test material
A, receive reagent thing medicine of the present invention, containing 2g crude drug/ml Institute Of Chinese Materia Medica Of China Academy of Chinese Medical Sciences and dosage form chamber provides lot number: 090811.Clinical consumption is 148g/ day, is calculated as 2.47g/kg by 60 kg body weight, the experiment selected clinical equivalent dosage and the dosage that doubles, rabbit with 15.30,7.65g/kg.
B, positive control drug aspirin effervescent tablets, AstraZeneca pharmaceutical Co. Ltd produces, and lot number is 080217; 1 slice/day of clinical consumption (every contains 0.5g); Be calculated as 0.017/kg by 60 kg body weight, experiment selected clinical equivalent dosage, rabbit is used 0.025g/kg.
C, animal rabbit, 1.5-2.0kg, male and female half and half, tonneau laboratory animal plant provides by the Xueyaun Road, Haidian District, Beijing City, the quality certification number: SCKX (capital) 2005-0003.
D, endotoxin escherichia coli endotoxin, the Sigma product is available from Beijing naval of section boat biotech development center.
E, instrument 7151 type thermisters, Shanghai Medical Instrument and Meter Factory produces.
2, test method and result
Method by the 244th page of " herbal pharmacology research methodology " (People's Health Publisher, Beijing, 1993) of Qi Chen chief editor detects medicine of the present invention causes fever in rabbit body temperature to endotoxin influence
Method is got healthy rabbits and is weighed, and the same day was surveyed normal rectal temperature 2 times in test.Selecting the anus temperature to differ 0.4 ℃ 38.5-39.5 ℃ and twice temperature is for experiment with interior animal.Test is established 6 groups, 6 every group altogether.Be respectively model control group, positive control drug group, two dose groups of medicine of the present invention (seeing table for details).Escherichia coli endotoxin with 140ng/ml/kg is injected by tame rabbit ear vein, after 1 hour, surveys anus temperature rise value, irritates stomach respectively after dividing into groups by the lift-off value adjustment and gives relative medicine.Model control group is irritated the distilled water of stomach with volume.Respectively surveyed the anus temperature once in 1,2,3,4 hour behind the medicine, surveyed anus temperature and basic anus using warming therapy difference, be the body temperature changing value with different time.
Table 1 medicine of the present invention is to the influence of endotoxin pyrogenic rabbit body temperature
Annotate: number of animals is 6; Compare * P＜0.05**P＜0.01 with model control group; Adopt the repeated measure variance analysis, prescription 2 heavy dose of groups and model group be P＜0.05 relatively
3, result
Result such as table 1 show that the 15.30g/kg dosage of medicine of the present invention causes that to endotoxin the fervescence of rabbit has certain inhibition effect.
The specific embodiment:
For making technical scheme of the present invention be convenient to understand, come the present invention is further described below in conjunction with experimental example.
Embodiment 1:
Take by weighing 10 parts of 6 parts of Herba Ephedrae (processed), 30 parts of Gypsum Fibrosum, 15 parts of Flos Loniceraes, 15 parts of Fructus Forsythiaes, 15 parts of Radix Scutellariaes, 10 parts of the Rhizoma Anemarrhenaes and Herba Artemisiae Annuaes, with being decocted in water for oral dose, every day potion.
Embodiment 2:
Take by weighing 3 parts of Herba Ephedrae (processed), 90 parts of Gypsum Fibrosum, 10 parts of Flos Loniceraes, 10 parts of Fructus Forsythiaes, 20 parts of Radix Scutellariaes, 6 parts of the Rhizoma Anemarrhenaes and and 15 parts of Herba Artemisiae Annuaes, with being decocted in water for oral dose, every day potion.
Embodiment 3:
Take by weighing 9 parts of Herba Ephedrae (processed), 60 parts of Gypsum Fibrosum, 30 parts of Flos Loniceraes, 30 parts of Fructus Forsythiaes, 30 parts of Radix Scutellariaes, 20 parts of the Rhizoma Anemarrhenaes and Herba Artemisiae Annuae 30, with being decocted in water for oral dose, every day potion.
Herba Ephedrae (processed) dispelling wind to relieve the exterior syndrome, Gypsum Fibrosum heat clearing away expelling pathogenic factors from muscles among the embodiment 1,2,3 are defended to the evil invasion and attack of poison lung and to be monarch drug; Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Herba Artemisiae Annuae and the Rhizoma Anemarrhenae have heat-clearing and toxic substances removing, strengthen the power of heat clearing away, increase the effect of the property of detoxifcation, is this side's ministerial drug.
Embodiment 4:
Take by weighing 6 parts of Herba Ephedrae (processed), 30 parts of Gypsum Fibrosum, 15 parts of Flos Loniceraes, 15 parts of Fructus Forsythiaes, 15 parts of Radix Scutellariaes, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Bulbus Fritillariae Thunbergiis, 9 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 15 parts of Fructus Arctiis and Herba Artemisiae Annuae 10, Herba Menthae 3, with being decocted in water for oral dose, every day potion.
Embodiment 5:
Take by weighing 3 parts of Herba Ephedrae (processed), 90 parts of Gypsum Fibrosum, 10 parts of Flos Loniceraes, 10 parts of Fructus Forsythiaes, 20 parts of Radix Scutellariaes, 6 parts of the Rhizoma Anemarrhenaes, 6 parts of Bulbus Fritillariae Thunbergiis, 3 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 20 parts of Fructus Arctiis and Herba Artemisiae Annuae 15, Herba Menthae 10, with being decocted in water for oral dose, every day potion.
Embodiment 6:
Take by weighing 9 parts of Herba Ephedrae (processed), 60 parts of Gypsum Fibrosum, 30 parts of Flos Loniceraes, 30 parts of Fructus Forsythiaes, 30 parts of Radix Scutellariaes, 20 parts of the Rhizoma Anemarrhenaes, 20 parts of Bulbus Fritillariae Thunbergiis, 6 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 10 parts of Fructus Arctiis and Herba Artemisiae Annuae 10, Herba Menthae 6, with being decocted in water for oral dose, every day potion.
Embodiment 4,5,6 has increased stir-baked SEMEN ARMENIACAE AMARUM, Bulbus Fritillariae Thunbergii and Fructus Arctii on the basis of embodiment 1,2,3, stir-baked SEMEN ARMENIACAE AMARUM slightly warm in nature bitter in the mouth wherein has the effect of sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation; Bulbus Fritillariae Thunbergii nature and flavor bitter cold has the effect of heat clearing away eliminating stagnation, preventing phlegm from forming and stopping coughing; Fructus Arctii is cold in nature, and acrid in the mouth, hardship have the effect of evacuation, lung qi dispersing rash, resolving toxin and disinhibiting the throat, have strengthened the heat clearing away eliminating stagnation of medicine, the curative effect of evacuation.
Embodiment 7:
Take by weighing Herba Ephedrae (processed) 6g, Gypsum Fibrosum 30g, Flos Lonicerae 15g, Fructus Forsythiae 15g, Radix Scutellariae 15g, Rhizoma Anemarrhenae 10g, Bulbus Fritillariae Thunbergii 10g, stir-baked SEMEN ARMENIACAE AMARUM 9g, Fructus Arctii 15g, Herba Artemisiae Annuae 15g, Herba Menthae 6g, Radix Glycyrrhizae 10g, with being decocted in water for oral dose, every day potion.
Embodiment 8:
Take by weighing 3 parts of Herba Ephedrae (processed), 90 parts of Gypsum Fibrosum, 10 parts of Flos Loniceraes, 10 parts of Fructus Forsythiaes, 20 parts of Radix Scutellariaes, 6 parts of the Rhizoma Anemarrhenaes, 6 parts of Bulbus Fritillariae Thunbergiis, 3 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 20 parts of Fructus Arctiis, Herba Artemisiae Annuae 10g, Herba Menthae 3g, Radix Glycyrrhizae 6g, with being decocted in water for oral dose, every day potion.
Embodiment 9:
Take by weighing 9 parts of Herba Ephedrae (processed), 60 parts of Gypsum Fibrosum, 30 parts of Flos Loniceraes, 30 parts of Fructus Forsythiaes, 30 parts of Radix Scutellariaes, 20 parts of the Rhizoma Anemarrhenaes, 20 parts of Bulbus Fritillariae Thunbergiis, 6 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 10 parts of Fructus Arctiis, Herba Artemisiae Annuae 30g, Herba Menthae 10g, Radix Glycyrrhizae 3g, with being decocted in water for oral dose, every day potion.
Embodiment 7～9 has increased Herba Artemisiae Annuae, Herba Menthae and Radix Glycyrrhizae on the basis of embodiment 4～6, wherein Herba Artemisiae Annuae is cold in nature, and bitter in the mouth, suffering have clearing away summer-heat, removes and steams, the effect of preventing the attack (or recurrence) of malaria; Cool in nature, the acrid in the mouth of Herba Menthae has dispelling wind, dispels the heat, wards off dirty, antidotal effect; Radix Glycyrrhizae property is put down sweet in the mouth, and the effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription is arranged, and auxiliary all the other medicines of these three kinds of medicines are given full play to clinical efficacy.
Embodiment 10:The preparation of Chinese medicinal tablet of the present invention:
(1) granulates: take by weighing Chinese medicine and the carboxymethyl starch sodium that arbitrary embodiment makes among the embodiment 1～9 in 3: 1 ratio of mass ratio according to Chinese medicine and carboxymethyl starch sodium; And carboxymethyl starch sodium is divided into two fens; Portion is that 1/3 amount is subsequent use; Another part is that 2/3 amount joins in the active component, is that 70% ethanol is that wetting agent is granulated with concentration, and the granule that makes is dry down in 60 ℃;
(2) tabletting: get dried particles, add the carboxymethyl starch sodium of 1/3 subsequent use amount and the magnesium stearate of tablet total weight amount 0.3%, depress to tablet with 3kN pressure.
Embodiment 11:The preparation of Chinese medicine granules of the present invention
Take by weighing the medical material described in arbitrary embodiment among the embodiment 1～9, decocte with water twice filters, and gets filtrating, and dry spissated extractum adds the lactose of 4 times of amounts of Chinese medicine, and mixing, granulating promptly gets.
Herba Ephedrae (processed), Gypsum Fibrosum are this side's main medicines in the present invention; Flos Lonicerae, Fructus Forsythiae, the Rhizoma Anemarrhenae and Radix Scutellariae; Being the important ancillary drug of prescription and the core that Herba Ephedrae (processed), Gypsum Fibrosum have formed prescription jointly, is the principal agent of therapeutic effect; Stir-baked SEMEN ARMENIACAE AMARUM, Bulbus Fritillariae Thunbergii, Fructus Arctii are the piths of strengthening this side's curative effect, and Herba Artemisiae Annuae, Herba Menthae, the auxiliary above medicine of Radix Glycyrrhizae are given full play to clinical efficacy.
The above; Being merely preferred embodiment of the present invention, is not that the present invention is done any formal and substantial restriction, allly is familiar with the professional and technical personnel; In not breaking away from technical scheme scope of the present invention; The technology contents that is disclosed more than capable of using, and a little change of making, modify the equivalent variations with differentiation, be equivalent embodiment of the present invention; Simultaneously, all foundations essence technology of the present invention all still belongs in the scope of technical scheme of the present invention change, modification and the differentiation of any equivalent variations that above embodiment did.
Claims (8)
1. the Chinese medicine of the influenza that caused by influenza A H1N1 influenza virus of a treatment is characterized in that said Chinese medicine processed by following bulk drugs: have 10～30 parts of 3～9 parts of Herba Ephedrae (processed), 30～90 parts of Gypsum Fibrosum, 10～30 parts of Flos Loniceraes, 10～30 parts of Fructus Forsythiaes, 15～30 parts of Radix Scutellariaes, 6～20 parts of the Rhizoma Anemarrhenaes and Herba Artemisiae Annuaes.
2. the Chinese medicine of the influenza that treatment according to claim 1 is caused by influenza A H1N1 influenza virus is characterized in that: the weight portion of said each composition is 15 parts of 6 parts of Herba Ephedrae (processed), 30 parts of Gypsum Fibrosum, 15 parts of Flos Loniceraes, 15 parts of Fructus Forsythiaes, 15 parts of Radix Scutellariaes, 10 parts of the Rhizoma Anemarrhenaes and Herba Artemisiae Annuaes.
3. the Chinese medicine of the influenza that caused by influenza A H1N1 influenza virus of a treatment is characterized in that said Chinese medicine processed by following bulk drugs: have 3～10 parts of 3～9 parts of Herba Ephedrae (processed), 30～90 parts of Gypsum Fibrosum, 10～30 parts of Flos Loniceraes, 10～30 parts of Fructus Forsythiaes, 15～30 parts of Radix Scutellariaes, 6～20 parts of the Rhizoma Anemarrhenaes, 10～30 parts of Herba Artemisiae Annuaes, 6～20 parts of Bulbus Fritillariae Thunbergiis, 3～10 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 10～20 parts of Fructus Arctiis and Herba Menthaes.
4. the Chinese medicine of the influenza that caused by influenza A H1N1 influenza virus of a treatment is characterized in that said Chinese medicine processed by following bulk drugs: have 3～9 parts of Herba Ephedrae (processed), 30～90 parts of Gypsum Fibrosum, 10～30 parts of Flos Loniceraes, 10～30 parts of Fructus Forsythiaes, 15～30 parts of Radix Scutellariaes, 6～20 parts of the Rhizoma Anemarrhenaes, 10～30 parts of Herba Artemisiae Annuaes, 6～20 parts of Bulbus Fritillariae Thunbergiis, 3～10 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 10～20 parts of Fructus Arctiis and 3～10 parts of Herba Menthaes, 3～10 parts of Radix Glycyrrhizae.
5. the Chinese medicine of the influenza that treatment according to claim 4 is caused by influenza A H1N1 influenza virus, it is characterized in that: the weight proportion of said each composition is 6 parts of Herba Ephedrae (processed), 30 parts of Gypsum Fibrosum, 15 parts of Flos Loniceraes, 15 parts of Fructus Forsythiaes, 15 parts of Radix Scutellariaes, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Bulbus Fritillariae Thunbergiis, 9 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 15 parts of Fructus Arctiis, 15 parts of Herba Artemisiae Annuaes, 6 parts of Herba Menthaes, 10 parts of Radix Glycyrrhizae.
6. the preparation method of Chinese medicine of an influenza that is caused by influenza A H1N1 influenza virus like any described treatment among the claim 1-5, it is characterized in that: said method for preparing is with described Chinese medicinal components decocting, or pulverize soaks and drinks.
7. the application of any described Chinese medicine in the medicine of the influenza that the preparation treatment is caused by influenza A H1N1 influenza virus among the claim 1-5.
8. the application of any described Chinese medicine in the medicine of the heating paresthesia of the influenza that the preparation treatment is caused by influenza A H1N1 influenza virus among the claim 1-5.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102501386A CN101708275B (en) | 2009-11-27 | 2009-11-27 | Chinese medicament for treating flu caused by influenza A(H1N1) and the like |
| PCT/CN2009/001378 WO2011063553A1 (en) | 2009-11-27 | 2009-12-04 | Traditional chinese medicine for treating flu induced by flu virus including type a h1n1 virus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102501386A CN101708275B (en) | 2009-11-27 | 2009-11-27 | Chinese medicament for treating flu caused by influenza A(H1N1) and the like |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101708275A CN101708275A (en) | 2010-05-19 |
| CN101708275B true CN101708275B (en) | 2012-11-28 |
Family
ID=42401097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009102501386A Expired - Fee Related CN101708275B (en) | 2009-11-27 | 2009-11-27 | Chinese medicament for treating flu caused by influenza A(H1N1) and the like |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN101708275B (en) |
| WO (1) | WO2011063553A1 (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102599336B (en) * | 2012-03-15 | 2013-03-13 | 湖南农业大学 | Composite aqueous extract of Fu brick tea and application thereof |
| CN102697906A (en) * | 2012-06-07 | 2012-10-03 | 佛山科学技术学院 | Compound Chinese medicinal preparation for preventing and treating swine influenza viruses |
| CN102755507B (en) * | 2012-06-28 | 2016-05-04 | 富阳原野生物科技有限公司 | A kind of traditional Chinese herbal decoction for the treatment of wind-dryness impariment of the lung type acute bronchitis |
| CN103223020A (en) * | 2013-05-21 | 2013-07-31 | 卫斌 | Medicine for treating viral cold and preparation method thereof |
| CN103272011B (en) * | 2013-06-09 | 2015-04-08 | 杨勇 | Pharmaceutical composition for treating flu and preparation method of pharmaceutical composition |
| CN103550618B (en) * | 2013-11-10 | 2014-06-11 | 李艳琴 | Medicine for preventing and treating infectious cold |
| CN105249473A (en) * | 2015-11-26 | 2016-01-20 | 安徽燕之坊食品合肥有限公司 | Coarse cereal dissolved medicine for treating child influenza and preparation method thereof |
| CN108310299A (en) * | 2018-05-11 | 2018-07-24 | 耿全好 | A kind of Chinese medicine preparation for treating sphagitis |
| CN111184805B (en) * | 2020-03-06 | 2021-07-23 | 江西曹洞慈善基金会 | Traditional Chinese medicine composition and application thereof |
| CN111249390A (en) * | 2020-03-12 | 2020-06-09 | 尧舜泽生物医药(南京)有限公司 | Forsythia-astragalus root compound preparation and preparation method and application thereof |
| CN111358892A (en) * | 2020-04-23 | 2020-07-03 | 徐修信 | Traditional Chinese medicine composition for treating novel coronavirus pneumonia in early and middle stages and preparation method thereof |
| CN111803588A (en) * | 2020-07-02 | 2020-10-23 | 武汉贝参药业股份有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for treating viral pneumonia |
| CN111840476A (en) * | 2020-08-31 | 2020-10-30 | 海南葫芦娃药业集团股份有限公司 | Traditional Chinese medicine composition and preparation for treating influenza as well as preparation method and application of traditional Chinese medicine composition and preparation |
| CN114712453B (en) * | 2021-01-06 | 2024-06-11 | 石家庄以岭药业股份有限公司 | Application of traditional Chinese medicine composition in medicines for resisting viruses, protecting viscera and improving immunity |
| CN113499381B (en) * | 2021-06-15 | 2022-07-01 | 首都医科大学附属北京中医医院 | Application of traditional Chinese medicine composition and/or pharmaceutical preparation containing traditional Chinese medicine composition in resisting influenza virus |
| CN113499383B (en) * | 2021-06-15 | 2022-07-01 | 首都医科大学附属北京中医医院 | Application of traditional Chinese medicine composition and/or pharmaceutical preparation containing traditional Chinese medicine composition in preparation of anti-inflammatory drugs or immunoregulation drugs |
| CN113855762B (en) * | 2021-09-18 | 2023-09-19 | 聚协昌(北京)药业有限公司 | Traditional Chinese medicine composition and preparation method and application thereof |
| CN114917298B (en) * | 2022-05-07 | 2023-10-20 | 森隆药业有限公司 | Pharmaceutical composition for treating pneumonia and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559524A (en) * | 2004-02-25 | 2005-01-05 | 江苏康缘药业股份有限公司 | Medicine for treating child cough and dyspnea due to the lung-heat and its preparaton method |
| CN1204915C (en) * | 2003-01-04 | 2005-06-08 | 辽宁中医学院 | Detoxification capsule and its prodn. methods |
| CN100457166C (en) * | 2006-01-23 | 2009-02-04 | 李月芬 | Chinese medicinal preparation for treating viral influenza |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4925534B2 (en) * | 2001-09-27 | 2012-04-25 | 宗鉄 丁 | Chinese medicine combination chewable tablets |
| CN1278709C (en) * | 2004-07-08 | 2006-10-11 | 林国辉 | Medicine for treating cold and its preparing process |
-
2009
- 2009-11-27 CN CN2009102501386A patent/CN101708275B/en not_active Expired - Fee Related
- 2009-12-04 WO PCT/CN2009/001378 patent/WO2011063553A1/en active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1204915C (en) * | 2003-01-04 | 2005-06-08 | 辽宁中医学院 | Detoxification capsule and its prodn. methods |
| CN1559524A (en) * | 2004-02-25 | 2005-01-05 | 江苏康缘药业股份有限公司 | Medicine for treating child cough and dyspnea due to the lung-heat and its preparaton method |
| CN100457166C (en) * | 2006-01-23 | 2009-02-04 | 李月芬 | Chinese medicinal preparation for treating viral influenza |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011063553A1 (en) | 2011-06-03 |
| CN101708275A (en) | 2010-05-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101708275B (en) | Chinese medicament for treating flu caused by influenza A(H1N1) and the like | |
| TWI792162B (en) | A compound traditional Chinese medicine with the function of clearing lung and expelling toxin and its application | |
| CN101601830B (en) | Chinese medicinal preparation for treating cold and preparation method thereof | |
| CN103394070B (en) | Treat grippal Chinese medicine preparation | |
| CN100389803C (en) | Chinese medicinal composition for treating wind-heat cold and preparation method thereof | |
| CN103169891A (en) | Novel vitamin C yinqiao tablet | |
| CN104189602A (en) | Pharmaceutical composition for treating hand-foot-and-mouth disease | |
| CN103211901A (en) | Lung clearing and inflammation diminishing medicament and preparation method thereof | |
| CN102657804A (en) | Traditional Chinese medical composition for treatment of viral influenza and preparation method thereof | |
| TW201201823A (en) | Chinese herbal medicine for treating influenza caused by A-type H1N1 viruses | |
| CN113577187B (en) | Traditional Chinese medicine composition and traditional Chinese medicine extract for treating influenza and preparation method and application thereof | |
| CN103191282B (en) | Traditional Chinese medicinal composition for treating fever in children as well as preparation method and application thereof | |
| CN109316551A (en) | A kind of Chinese medicine composition and preparation method thereof for treating acpuei pharyngitis | |
| CN104983968A (en) | Pyretolysis traditional Chinese medicine composition and preparation method | |
| CN102526236B (en) | Pharmaceutical formulation for treating influenza and preparation method thereof | |
| CN101549012A (en) | Traditional Chinese medicine composition for treating throat diseases and preparation method thereof | |
| CN103933343B (en) | A kind of Chinese medicinal pill for the treatment of bronchial asthma | |
| CN103040997A (en) | Prokinetic traditional Chinese medicinal composition and preparation and application thereof | |
| CN102836203B (en) | Traditional Chinese medicine composition for treating wind-heat type common cold as well as preparation method and application thereof | |
| CN102451401A (en) | Recipe of vitamin C lonicera and forsythia | |
| CN101554446A (en) | Traditional Chinese medicine composition for treating chronic pharyngitis | |
| CN105327182A (en) | Medicine for treating child pertussis and preparation method thereof | |
| CN103961554A (en) | Medicine for treating acute lingual tonsilitis and preparation method thereof | |
| CN103394064A (en) | Traditional Chinese medicine composition used for treating slight cold | |
| CN102058792A (en) | Traditional Chinese medicine preparation for treatment of cold and cough |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170809 Address after: 102606 Beijing City, Daxing District science and Technology Park Administration Beijing Tianjin Tanggu Caiyu Town Road No. 1 Patentee after: JUXIECHANG (BEIJING) PHARMACEUTICAL CO.,LTD. Address before: 100035 Beijing city Xicheng District Xinjiekou water alley No. 13 Patentee before: Institute of Clinical Pharmacy of Beijing Health Bureau |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121128 Termination date: 20211127 |