CN1226033C - Method for preparing traditional Chinese medicine concentrated pill - Google Patents
Method for preparing traditional Chinese medicine concentrated pill Download PDFInfo
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- CN1226033C CN1226033C CN 03124244 CN03124244A CN1226033C CN 1226033 C CN1226033 C CN 1226033C CN 03124244 CN03124244 CN 03124244 CN 03124244 A CN03124244 A CN 03124244A CN 1226033 C CN1226033 C CN 1226033C
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Abstract
One aspect of the present invention relates to a preparation method of a concentrated pill of traditional Chinese medicine, which comprises the following steps that A. traditional Chinese herbal medicines are selected according to prescribed components or are reserved after general processing; B. extract is extracted from the herbal medicines in step A, filtered, blended and concentrated into ointment; C. the ointment obtained in step B are dried into fine powder, then a small amount of supplementary materials are added, and a granule is prepared by a dry method; D. a dry pill is obtained by pressing the granule into the pill. The other aspect of the present invention also relates to a preparation method of a concentrated pill of traditional Chinese medicine, which comprises the following steps that A. traditional Chinese herbal medicines are selected according to prescribed components or are reserved after general processing; B. extract is extracted from the herbal medicines in step A, filtered, blended and concentrated into ointment, and the other part of the herbal medicines are crushed into fine powder; C. the obtained ointment and the obtained fine powder are made into a granule; D. a dry pill is obtained by pressing the granule into the pill.
Description
Invention field
The present invention relates to the preparation method of Chinese medicine concentrated pill.
Background technology
The Chinese medicine concentrated pill means the clear paste or the extractum of medical material or part medicinal material extract, the pill made from an amount of adjuvant or fine drug powder (an appendix rules of preparations of Chinese Pharmacopoeia version in 2000 item is regulation down).Its preparation is the universal method that adopts the medicine pill preparation basically, pharmacy teaching material＜pharmaceutics〉(Zou Lijia chief editor, Chinese Medicine science and technology publishing house, 1996.11) once the preparation method of pill was divided into and moulds method for making, general method for making and dropping preparation method, pill is single-row to be a kind of dosage form but version Chinese Pharmacopoeia in 2000 will drip.So, at present the preparation method of pill has only traditional method for making and general method for making of moulding, be that the extract of medical material or medical material fine powder are wet pill through the multiple working procedure preliminarily forming, form pill drying through long time drying again, be fit to primary crude drug and pulverize the Chinese medicine dosage form (honeyed pill, water-honeyed pill, the watered pill) of being used as medicine.To this dosage form of concentrated pill, adopt these two kinds of methods that significant limitation is arranged.To this, we have invented a kind of new pressing, and this method is to adopt modern drying equipment and technology with medicinal substances extract or cream powder mixture, at first is dried to granule, once is pressed into pill drying then.
Mould method for making and prepare concentrated pill, be meant whole extracts of medical material or extracting section thing and medical material fine powder, add suitable adjuvant, mix homogeneously forms the suitable plasticity ball piece of humidity, and divided dose is made the method for pill.Technology can be represented with Fig. 1 simply.
General method for making prepares concentrated pill, if medical material all extracts, should be earlier with the medicinal substances extract mixing, and drying is ground into fine powder, the pill mould; If medical material only needs extracting section, another part is ground into fine powder, then fine powder (can all should be added, also can stay a part in general system process, to add with wetting agent) add mixing in the extract, drying also is ground into powder, makes the ball mould, by suitable container or machinery ball mould and excipient are replaced moistening, spread the step, constantly roll, the ball mould is increased gradually, till up to specification, dry then, capping carries out drying afterwards again, put in order the method for pill.
Its process chart as shown in Figure 2.
More than two kinds of preparation methoies, all being material begins to take shape wet medicine grain through multiple working procedure, drying becomes exsiccant pill again.Exist following shortcoming:
1, complex procedures, producers' many (for example pill → ball piece → ball bar → wet pills → dry → pick → pill, or medicine → ball mould → wet pill → oven dry → capping → drying → pick → pill);
2, the cycle long (mainly being that drying time is long,, being no more than according to the pill drying condition under 80 ℃ the situation that the time is also more than 24 hours) because after making the pill that wets, diameter is generally 2-8mm;
3, the drug exposure time outside long, opportunities for contamination is many;
4, yield rate low (wet pill easily pushes modification in drying course).
Summary of the invention
In view of above reason, we provide a kind of new method, and this method is to utilize modern advanced equipment and technology, make medicinal substances extract or the rapid draing of cream powder mixture become solid fines to make granule or convection drying becomes granule through dry method, once are pressed into pill.This method has not only overcome the deficiency of at present existing concentrated pill preparation method, and can make the product that makes have following advantage:
1, the little and taking dose of dose accurately (mainly be that the adjuvant that adds is few, the pill size that makes is easy to control, and the ball method of double differences is different little);
2, the molten diffusing time is short, (the disintegration time pharmacopeia regulation of concentrated pill is no more than 2 hours in the dissolution raising, generally also all be about 1.5 hours, the pill that this new method makes then can be controlled in 0.5 hour, dissolution can be detected index as one of quality standard);
3, can ensure clinical efficacy (adopt spray drying or further granulation, drying time is short, and the pill effective ingredient is not subject to and destroys or volatilization) in dry run.
Therefore, in one aspect of the invention, provide a kind of preparation method of Chinese medicine concentrated pill, having comprised:
A, get the Chinese crude drug or standby after routine is concocted of respectively distinguishing the flavor of according to the prescription composition;
B, the medical material of steps A is extracted, with extracting liquid filtering, mixing is condensed into ointment;
C, the ointment of step B gained is dried to fine powder (for example and preferred adopt rapid draing such as spray drying device), adds a spot of adjuvant dry method to make granule;
D, with the granule pelleting, promptly get dried pill.
In the preferred version of the present invention aspect this, preparation method of the present invention comprises:
A, get the Chinese crude drug or standby after routine is concocted of respectively distinguishing the flavor of according to the prescription composition;
B, with the medical material of steps A, according to the difference of character, select suitable mode to extract respectively, with extracting liquid filtering, mixing is condensed into ointment;
C, the ointment of step B gained is dried to fine powder (for example and preferred adopt rapid draing such as spray drying device), adds a spot of adjuvant dry method to make granule; With
D, with the granule pelleting, promptly get dried pill.
Wherein adjuvant comprises the usual pharmaceutical acceptable carrier, cellulose for example, modified cellulose, starch, modified starch, magnesium stearate, lactose, calcium stearate etc.
Wherein among the step B, the rule that the mode of medicinal material extract is handled according to following raw material is carried out:
A, starch-containing more medical material (as Rhizoma dioscoreae, Radix Trichosanthis etc.), valuable medicine, malicious drastic (as Calculus Bovis, Realgar etc.) that consumption is few; Some contains a small amount of fragrant volatile ingredient medical material and (regards as equal and some mineral drug (as Gypsum Fibrosum etc.) all should be ground into fine powder as Borneolum Syntheticum, the Radix Aucklandiae, Fructus Amomi.
B, contain the more medical material of volatile ingredient (as Herba Schizonepetae, Herba Menthae, Folium Perillae, Fructus Forsythiae etc.), can extract volatile ingredient (mostly being volatile oil).
C, the clear and definite person of effective ingredient can adopt the specific method effective component extracting, as (their extracting method are open in the literature) such as astragaloside, berberine, isochlorogenic acid according to the effective ingredient characteristic.
D, contain pure soluble components, as alkaloid, flavonoid glycoside etc., available different concentration ethanol is extracted.
E, fibre-bearing is more, viscosity is bigger or scleroid medical material, as Pericarpium Arecae, Spica Prunellae, Radix Rehmanniae Preparata, Concha Haliotidis etc., adopts decocting to extract.
In another aspect of the present invention, provide a kind of preparation method of Chinese medicine concentrated pill, having comprised:
A, according to the prescription composition get the Chinese crude drug or standby after concocting of respectively distinguishing the flavor of;
B, the medical material of steps A is extracted, with extracting liquid filtering, merge, mixing is condensed into ointment; Another part pulverizing medicinal materials becomes fine powder;
C, above-mentioned gained ointment and fine powder are made granule (for example and preferably utilizing one-step-granulating method); With
D, with the granule pelleting, promptly get dried pill.
In the preferred version of the present invention aspect this, preparation method of the present invention comprises:
A, according to the prescription composition get the Chinese crude drug or standby after concocting of respectively distinguishing the flavor of;
B, with the medical material of steps A, according to the difference of character, a part selects suitable mode to extract respectively, with extracting liquid filtering, merges, mixing is condensed into ointment; Another part pulverizing medicinal materials becomes fine powder;
C, above-mentioned gained ointment and fine powder are made granule (for example and preferably utilizing one-step-granulating method); With
D, with the granule pelleting, promptly get dried pill.
Wherein among the step B, the rule that the mode of medicinal material extract is handled according to following raw material is carried out:
A, starch-containing more medical material (as Rhizoma dioscoreae, Radix Trichosanthis etc.), valuable medicine, malicious drastic (as Calculus Bovis, Realgar etc.) that consumption is few; Some contains a small amount of fragrant volatile ingredient medical material and (regards as equal and some mineral drug (as Gypsum Fibrosum etc.) all should be ground into fine powder as Borneolum Syntheticum, the Radix Aucklandiae, Fructus Amomi.
B, contain the more medical material of volatile ingredient (as Herba Schizonepetae, Herba Menthae, Folium Perillae, Fructus Forsythiae etc.), can extract volatile ingredient (mostly being volatile oil).
C, the clear and definite person of effective ingredient can adopt the specific method effective component extracting, as astragaloside, berberine, isochlorogenic acid etc. according to the effective ingredient characteristic.
D, contain pure soluble components, as alkaloid, flavonoid glycoside etc., available different concentration ethanol is extracted.
E, fibre-bearing is more, viscosity is bigger or scleroid medical material, as Pericarpium Arecae, Spica Prunellae, Radix Rehmanniae Preparata, Concha Haliotidis etc., adopts decocting to extract.
Wherein the part of Ti Quing should account for the 25-100% of whole medical material gross weights, preferred 51-100%, more preferably 70-100%.
Description of drawings
Fig. 1 is the existing process chart that method for making prepares concentrated pill of moulding.
Fig. 2 is the process chart that existing general method for making prepares concentrated pill.
Specific embodiment
Followingly further set forth the present invention, should be noted that these embodiment only are used for illustrative purposes, do not limit the scope of the invention with reference to embodiment.
Embodiment 1
The preparation method one of Chinese medicine LIUWEI DIHUANG WAN
1, form by the prescription of LIUWEI DIHUANG WAN, get 160 parts in Radix Rehmanniae Preparata, 80 parts of Fructus Corni, 60 parts of Cortex Moutans, 80 parts of Rhizoma Dioscoreaes, 60 parts in Poria, 60 parts of Rhizoma Alismatis, standby after concoct the GMP cleaning shop;
2,60 parts Cortex Moutan extracts paeonol with vapor distillation, gets the paeonol crystallization, vacuum drying, and it is standby to be ground into the paeonol fine powder, and medicinal residues are used in addition;
3, Cortex Moutan medicinal residues and Fructus Corni are 27 parts, and Radix Rehmanniae Preparata, Poria, Rhizoma Alismatis are respectively 160 parts, 60 parts, 60 parts and decoct with water twice, and each 2 hours, collecting decoction filtered, and the simmer down to relative density is 1.05～1.20 thick paste;
4,53 parts of Fructus Corni of residue and 80 parts of Rhizoma Dioscoreae powders are broken into fine powder, sieve mixing;
5, with 2 step gained paeonol fine powders, 4 step gained medical material fine powder mixings, make granule through one-step-granulating method with 3 step gained ointment;
6, the granule diameter with above-mentioned gained is the drift pelleting of 5.5 ~ 8.0mm, gets exsiccant pill, and sugar coating or film-coat get finished product.
The concentrated pill secundum legem testing result that this technology makes is:
Differentiate: Fructus Corni should detect ursolic acid; Cortex Moutan should detect paeonol
Assay: contain Cortex Moutan by paeonol (C
9H
10O
31) meter, must not be less than 0.18%
Contain Fructus Corni by ursolic acid (C
30H
48O
3) meter, must not be less than 0.02%
Microbiological examination: antibacterial :≤500/g mycete≤60/g
Escherichia coli, demodicid mite alive: must not detect.
Embodiment 2
The preparation method two of classical Chinese medicine LIUWEI DIHUANG WAN
1, form by the prescription of LIUWEI DIHUANG WAN, get 160 parts in Radix Rehmanniae Preparata, 80 parts of Fructus Corni, 60 parts of Cortex Moutans, 80 parts of Rhizoma Dioscoreaes, 60 parts in Poria, 60 parts of Rhizoma Alismatis, standby after concoct the GMP cleaning shop;
2,60 parts Cortex Moutan is extracted paeonol with vapor distillation, the paeonol crystallization, vacuum drying, it is standby to be ground into the paeonol fine powder, medicinal residues are used in addition;
3, Cortex Moutan medicinal residues and Fructus Corni, Radix Rehmanniae Preparata, Poria, Rhizoma Alismatis are respectively 80 parts, 160 parts, 60 parts, 60 parts and decoct with water twice, and each 2 hours, collecting decoction filtered, and the simmer down to relative density is 1.05～1.20 thick paste;
4, Rhizoma Dioscoreae decocts with water three times, and first and second time respectively is 2 hours, is 1 hour for the third time, and collecting decoction filters, and is condensed into thick paste;
5, with the ointment mixing of above-mentioned 3 and 4 step gained, be spray dried to fine powder, add starch or the dextrin mixing of 7-9%, dry method is made granule;
6, above-mentioned granule adds the magnesium stearate of 0.3-0.8% and carboxymethyl starch to mix the back thoroughly is the drift pelleting of 5.5-8.0mm with diameter, makes exsiccant pill, and sugar coating or film-coat get product.The concentrated pill secundum legem testing result that this technology makes is:
Assay: contain Cortex Moutan by paeonol (C
9H
10O
3) meter, must not be less than 0.18%
Contain Fructus Corni by ursolic acid (C
30H
48O
3) meter, must not be less than 0.02%
Microbiological examination: antibacterial :≤500/g mycete≤60/g
Escherichia coli, demodicid mite alive: must not detect.
Embodiment 3
The preparation method of FUFANG DANSHEN WAN
1, form by the prescription of FUFANG DANSHEN WAN, get Radix Salviae Miltiorrhizae 270g, Radix Notoginseng 94.6g, it is standby that Borneolum Syntheticum 4.8g concocts the back;
2, the 270g Radix Salviae Miltiorrhizae is added 6 times of amounts of ethanol of 95%, flood percolation after 12 hours, percolate recovery ethanol was to medical material 1: 0.5, and is standby; Medicinal residues add 6 times of amounts of 50% ethanol, reflux 1.5 hours, and backflow reclaims ethanol, and is standby; Medicinal residues add 8 times of water gagings again and decocted 2 hours, reflux 1.5 hours, and medicinal residues discard, and decocting liquid merges with the backflow that reclaims behind the ethanol, are condensed into concentration and are 1.18 ~ 1.20 (heat surveys)
Rare cream is emitted 1/3 standbyly, and residue 2/3 continues to be condensed into the thick paste that density is 1.45 (heat is surveyed), and is standby;
3, the powder process of 94.6g Radix Notoginseng is standby;
4, with above-mentioned Radix Salviae Miltiorrhizae thick paste, mix thoroughly with above-mentioned Radix Notoginseng powder, bake dried cream;
5, get the Borneolum Syntheticum beta-cyclodextrin inclusion compound of 4.8g, additional proportion is a Borneolum Syntheticum: beta-schardinger dextrin-: water=1: 6: 50, Borneolum Syntheticum clathrate drying for standby;
6, above-mentioned dried cream and Borneolum Syntheticum clathrate mixed powder are broken into fine powder, standby;
7, the percolate behind rare cream of Radix Salviae Miltiorrhizae and the recovery ethanol is merged as binding agent, put spray drying granulation mechanism grain with above-mentioned medicated powder;
8, above-mentioned granule adds 0.3% magnesium stearate and carboxymethyl starch sodium to mix the back thoroughly is the drift pelleting of 6.0mm with diameter, wraps the film-coat pill that gets product.
The product secundum legem testing result that adopts this technology to make is:
Differentiate: detect Borneolum Syntheticum, tanshinone, arasaponin RI
Assay: the every 1g of this product contains danshensu sodium (CHON) meter, must not be less than 3.7mg
Hygiology: antibacterial :≤500/g mycete≤60/g
Escherichia coli, demodicid mite alive: must not detect.
Claims (12)
1, a kind of preparation method of Chinese medicine concentrated pill comprises:
A, get the Chinese crude drug or standby after routine is concocted of respectively distinguishing the flavor of according to the prescription composition;
B, the medical material of steps A is extracted, with extracting liquid filtering, mixing is condensed into ointment;
C, the ointment of step B gained is dried to fine powder, adds a spot of adjuvant dry method and make granule; With
D, with the granule pelleting, promptly get dried pill.
2, according to the process of claim 1 wherein that step B replaces with following step B ':
B ', with the medical material of steps A, according to the difference of character, select suitable mode to extract respectively, with extracting liquid filtering, mixing is condensed into ointment.
3, according to the method for claim 2, wherein among the step B ', the rule that the mode of medicinal material extract is handled according to following raw material is carried out:
A, contain the more medicinal material extract volatile ingredient of volatile ingredient;
B, the clear and definite person of effective ingredient according to the effective ingredient characteristic, adopt the specific method effective component extracting;
C, contain pure soluble components, extract with different concentration ethanol; With
D, fibre-bearing is more, viscosity is bigger or scleroid medical material, adopts decocting to extract.
4, a kind of preparation method of Chinese medicine concentrated pill comprises:
A, according to the prescription composition get the Chinese crude drug or standby after concocting of respectively distinguishing the flavor of;
B, the medical material of steps A is extracted, with extracting liquid filtering, merge, mixing is condensed into ointment; Another part pulverizing medicinal materials becomes fine powder;
C, above-mentioned gained ointment and fine powder are made granule; With
D, with the granule pelleting, promptly get dried pill.
5, according to the method for claim 4, wherein step B replaces with following step B ':
B ', with the medical material of steps A, according to the difference of character, a part selects suitable mode to extract respectively, with extracting liquid filtering, merges, mixing is condensed into ointment; Another part pulverizing medicinal materials becomes fine powder;
6, according to the method for claim 5, wherein among the step B ', the rule that the mode of medicinal material extract is handled according to following raw material is carried out:
A, starch-containing more medical material, valuable medicine, malicious drastic that consumption is few; Contain a small amount of fragrant volatile ingredient medical material and mineral drug and all be ground into fine powder;
B, contain the more medicinal material extract volatile ingredient of volatile ingredient;
C, the clear and definite person of effective ingredient according to the effective ingredient characteristic, adopt the specific method effective component extracting;
D, contain pure soluble components, extract with different concentration ethanol; With
E, fibre-bearing is more, viscosity is bigger or scleroid medical material, adopts decocting to extract.
7, according to the method for claim 5, wherein the part of Ti Quing should account for the 25-100% of whole medical material gross weights.
8,, it is characterized in that the part of wherein extracting should account for the 51-100% of whole medical material gross weights according to the method for claim 7.
9, method according to Claim 8 is characterized in that the part of wherein extracting should account for the 70-100% of whole medical material gross weights.
10, the preparation method of the Chinese medicine concentrated pill of LIUWEI DIHUANG WAN comprises:
A, form, get 160 parts in Radix Rehmanniae Preparata, 80 parts of Fructus Corni by the prescription of LIUWEI DIHUANG WAN, 60 parts of Cortex Moutans, 80 parts of Rhizoma Dioscoreaes, 60 parts in Poria, 60 parts of Rhizoma Alismatis, concoct the back in the GMP cleaning shop standby;
B, 60 parts Cortex Moutan extract paeonol with vapor distillation, the paeonol crystallization, vacuum drying, it is standby to be ground into the paeonol fine powder, medicinal residues are used in addition;
27 parts of C, Cortex Moutan medicinal residues and Fructus Corni, Radix Rehmanniae Preparata, Poria, Rhizoma Alismatis are respectively 160 parts, 60 parts, 60 parts and decoct with water twice, and each 1-3 hour, collecting decoction filtered, and the simmer down to relative density is 1.05～1.20 thick paste;
D, 53 parts of Fructus Corni of residue and 80 parts of Rhizoma Dioscoreae powders are broken into fine powder, sieve mixing;
E, B is gone on foot gained paeonol fine powder, D step gained medical material fine powder mixing, make granule through one-step-granulating method with C step gained ointment;
F, be the drift pelleting of 5.5-8.0mm with the granule diameter of above-mentioned gained, exsiccant pill, sugar coating or film-coat get finished product.
11, the preparation method of the concentrated pill of LIUWEI DIHUANG WAN comprises
A, form, get 160 parts in Radix Rehmanniae Preparata, 80 parts of Fructus Corni by the prescription of LIUWEI DIHUANG WAN, 60 parts of Cortex Moutans, 80 parts of Rhizoma Dioscoreaes, 60 parts in Poria, 60 parts of Rhizoma Alismatis, concoct the back in the GMP cleaning shop standby;
B, 60 parts Cortex Moutans are extracted paeonol with vapor distillation, the paeonol crystallization, vacuum drying, it is standby to be ground into the paeonol fine powder, medicinal residues are used in addition;
C, Cortex Moutan medicinal residues and Fructus Corni, Radix Rehmanniae Preparata, Poria, Rhizoma Alismatis are respectively 80 parts, 160 parts, 60 parts, 60 parts and decoct with water twice, and each 1-3 hour, collecting decoction filtered, and the simmer down to relative density is 1.05～1.20 thick paste;
D, Rhizoma Dioscoreae decoct with water three times, and first and second time respectively is 1-3 hour, are 0.5-2 hour for the third time, and collecting decoction filters, and is condensed into thick paste;
E, with the ointment mixing of above-mentioned C and D step gained, be spray dried to fine powder, add starch or the dextrin mixing of 7-9%, dry method is made granule;
F, above-mentioned granule add magnesium stearate and the carboxymethyl starch of 0.3-0.8% and mix thoroughly back to be the drift pelleting of 5.5-8.0mm with diameter, to make exsiccant pill that sugar coating or film-coat get product.
12, the preparation method of the concentrated pill of FUFANG DANSHEN WAN comprises:
A, form, get 270 parts of Radix Salviae Miltiorrhizaes by the prescription of FUFANG DANSHEN WAN, 94.6 parts of Radix Notoginseng, standby after 4.8 parts of processes of preparing Chinese medicine of Borneolum Syntheticum;
B, 270 parts of Radix Salviae Miltiorrhizaes are added ethanol 3-10 doubly measure, flood after 8-18 hour percolation percolate recovery ethanol about 1: 0.5 to medical material, standby; Medicinal residues add ethanol 3-10 doubly to be measured, and backflow 1-2 hour, backflow reclaims ethanol, and was standby; Medicinal residues add 5-12 times of water gaging again and decocted 1-3 hour, and backflow 1-2 hour, medicinal residues discarded, decocting liquid merges with the backflow that reclaims behind the ethanol, and being condensed into concentration is rare cream that 1.18-1.20 heat is surveyed, and emits about 1/3 standby, remain about 2/3 and continue to be condensed into the thick paste that density is about 1.45 heat surveys, standby;
C, the powder process of 94.6 portions of Radix Notoginseng is standby;
D, with above-mentioned Radix Salviae Miltiorrhizae thick paste, mix thoroughly with above-mentioned Radix Notoginseng powder, bake dried cream;
E, get 4.8 parts Borneolum Syntheticum beta-cyclodextrin inclusion compound, additional proportion is a Borneolum Syntheticum: beta-schardinger dextrin-: water=1: 5-7: 45-55, Borneolum Syntheticum clathrate drying for standby;
F, above-mentioned dried cream and Borneolum Syntheticum clathrate mixed powder are broken into fine powder, standby;
G, with the rare cream of Radix Salviae Miltiorrhizae and the percolate after reclaiming ethanol merge as binding agent, put spray drying granulation mechanism grain with above-mentioned medicated powder.
H, above-mentioned granule add the 0.2-0.6% magnesium stearate and carboxymethyl starch sodium is mixed back drift pelleting thoroughly, wraps the film-coat pill that gets product.
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| CN 03124244 CN1226033C (en) | 2003-04-30 | 2003-04-30 | Method for preparing traditional Chinese medicine concentrated pill |
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|---|---|---|---|
| CN 03124244 CN1226033C (en) | 2003-04-30 | 2003-04-30 | Method for preparing traditional Chinese medicine concentrated pill |
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| CN1226033C true CN1226033C (en) | 2005-11-09 |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102920882B (en) * | 2011-11-01 | 2017-05-17 | 九芝堂股份有限公司 | Concentrated Liuwei dihuang pill preparation method |
| CN103432157A (en) * | 2013-09-06 | 2013-12-11 | 兰州理工大学 | Preparation method of concentrated pills of angelica sinensis and astragalus membranaceus polysaccharide |
| CN107617036B (en) * | 2016-07-13 | 2021-04-30 | 桂林三金药业股份有限公司 | Pill of six ingredients with rehmannia and preparation process thereof |
| CN109105734A (en) * | 2018-08-17 | 2019-01-01 | 葛强 | A kind of novel herbal paste production method |
| CN111281853B (en) * | 2018-12-07 | 2022-04-05 | 桂林三金药业股份有限公司 | Preparation method of traditional Chinese medicine concentrated pill |
| CN110037331A (en) * | 2019-03-20 | 2019-07-23 | 福建绿色黄金生物科技有限公司 | A kind of processing method and its application of roxburgh anoectochilus terminal bud |
| CN112402470A (en) * | 2020-12-10 | 2021-02-26 | 南昌大学 | Chimonanthus nitens leaf concentrated pill and preparation method thereof |
| CN115282122A (en) * | 2022-08-10 | 2022-11-04 | 宁夏启元国药有限公司 | Process for preparing concentrated Chinese medicinal pill |
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