CN1296073C - Method for preparing a gynecopathy treating medicine - Google Patents
Method for preparing a gynecopathy treating medicine Download PDFInfo
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- CN1296073C CN1296073C CNB2004100233205A CN200410023320A CN1296073C CN 1296073 C CN1296073 C CN 1296073C CN B2004100233205 A CNB2004100233205 A CN B2004100233205A CN 200410023320 A CN200410023320 A CN 200410023320A CN 1296073 C CN1296073 C CN 1296073C
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a preparation method of a medicine for treating gynecopathy. The medicine is prepared from dangshen, Zanthoxylum dissitum Hemsl, mahonia stem, cherokee rose root, radix moghania, leatherleaf milletia angelica and creat. The preparation method comprises that the creat is extracted and filtered by ethanol with a heating reflux or percolating reflux method; after the ethanol is recovered, the extracted and filtered creat is concentrated into spare extract; medical dregs are reserved for standby; the dangshen, the Zanthoxylum dissitum Hemsl, the mahonia stem, the cherokee rose root, the radix moghania and the leatherleaf milletia are put in an extractor to be extracted with water for the first time; then, filtration dregs and creat dregs are merged to be filtered for the second time; afterwards, the filtered liquids of the two times are merged and are concentrated into spare extract whose specific weight is 1.08/80 DEG C; the angelica is pulverized into a micron and nanometer mixed powdery material; the powdery material and the extract are granulated, dried and pressed into a tablet patent medicine after being uniformly mixed. The method enhances bioavailability, enhances the therapeutic effect of the medicine, decreases dosage and improves working environment.
Description
Technical field
The present invention relates to a kind of process for preparing medicine for the treatment of gynaecopathia, referring in particular to Chinese crude drug Fructus Zanthoxyli Dissiti, Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, Caulis Spatholobi, Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis is the manufacture method of gynecological's Chinese patent medicine of raw material.
Background technology
The patent No. is a kind of claimed manufacturing technique method that ZL98112696.0's " a kind of process for preparing medicine for the treatment of gynaecopathia " " FUKE QIANJIN PIAN " that to be the applicant produce for company at that time on October 21st, 1998 proposes.In above-mentioned disclosed production method, its protection fundamentally mainly embodies a concentrated reflection of both ways: the first is ground into fine powder more than 100 orders with Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis three flavor Chinese crude drugs in pulverizer, leaves and takes 93.3% standby; It two is that Fructus Zanthoxyli Dissiti, Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis and the Caulis Spatholobi Chinese medicine of the five flavours that will choose is placed in the extraction pot together, adds hot water and extracts twice by the method for extracting once in quick 2 hours, crosses leaching liquid; Proportion is 10.8/80 ℃ extractum in then extracting solution being concentrated in the triple effect concentrator.
Then, my company has proposed medicine---the FUKE QIANJIN PIAN with the treatment gynaecopathia again, production method with two kinds of capsules of identical prescription, and submitted the patent application (patent No. and application number are respectively: 99115682.x, 99115683.8) of two kinds of capsule manufacture methods on the 7th in December in 1999 to State Patent Office.
In the manufacture method of these two kinds of capsules, its main characteristics is: Radix Angelicae Sinensis and this two flavors Chinese medicine of Herba Andrographis are extracted both effective ingredient with alcohol heating reflux method or alcohol percolation method together or respectively, to reach the content that both reduces fecula material in the patent medicine, improve the amount of effective ingredient again, thereby make the patient both reduce dosage, can keep good efficacy again.
Though production practices for many years show above-mentioned kinds of processes method and are successfully effective in the production of instructing " FUKE QIANJIN PIAN ".But along with deep development to the Chinese crude drug pharmacological research, especially in today of other subject technology develop rapidly, be based upon the production method of " FUKE QIANJIN PIAN " series of products on traditional Chinese patent medicine manufacturing technique method, the demand of incompatibility development of the situation.Therefore, how to guarantee under the product quality prerequisite, further reduce production costs,, become the producer that produces this product and scientific research personnel's a main direction for society and patient provide the preparation method of the medicine of more effective, more economical treatment gynaecopathia.
Technology contents
Purpose of the present invention: be intended on the basis of forefathers to " FUKE QIANJIN PIAN " series of products and technical study, under the prerequisite that does not change its basic prescription compatibility, a kind of more scientific and rational process for preparing medicine that can treat gynaecopathia is proposed, wish that it can not only continue to keep good drug effect, also can further improve simultaneously the utilization rate of Chinese material medicine resource, thereby bring better economic benefit and benefit for manufacturer.
The preparation method of the medicine of this treatment gynaecopathia, it is made by Radix Codonopsis, Fructus Zanthoxyli Dissiti, Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, Caulis Spatholobi, Radix Angelicae Sinensis, Herba Andrographis, it is characterized in that preparing as follows:
A, the Chinese crude drug 9 weight portion Herba Andrographis chosen are extracted with alcohol heat reflux method or alcohol percolation method filter, through reclaiming ethanol, and filtrate is condensed into proportion is 1.08/80 ℃ standby extractum, and medicinal residues are standby;
B, the 9 weight portion Radix Codonopsis that will choose, 9 weight portion Fructus Zanthoxyli Dissiti, 16 weight portion Caulis Mahoniaes, 16 weight portion Radix Rosae Laevigataes, 16 weight portion Radix Flemingiae Philippinensiss, 16 weight portion Caulis Spatholobi Six-element Chinese crude drugs are put together and are placed extractor, and decocting in water extracted once in 2 hours, crossed leaching liquid; And the extraction again after 2 hours with this filtering residue and A operation Herba Andrographis medicinal residues merging decocting in water, filtration is taken off slag and is got filtrate; Twice gained filter rear filtrate is merged, and to be condensed into proportion be 1.08/80 ℃ standby extractum;
C, will in pulverizer, be ground into by the 9 weight portion Radix Angelicae Sinensis that prescription is chosen based on the micron order of 0.1-1.0 μ m particle diameter and particle diameter mixed powder less than the nano-scale particle of 0.1 μ m, and by at least 95% the powder rate be left and taken standby;
The extractum mixing that D, the Radix Angelicae Sinensis powder that will obtain from C technology and two technologies of A, B are obtained is respectively granulated later on, and drying is made tablet patent medicine through tabletting, or makes capsule drug through fill.
Described Fructus Zanthoxyli Dissiti, Caulis Mahoniae two flavor Chinese crude drugs and Radix Rosae Laevigatae, very heavy group, Caulis Spatholobi, Radix Codonopsis four flavor Chinese crude drugs separate independent decocting in water extraction and obtain standby extractum; And Radix Rosae Laevigatae, very heavy group, Caulis Spatholobi, Radix Codonopsis are placed extractor, decocting in water extracts once, cross leaching liquid, and after again the merging of the Herba Andrographis medicinal residues in this filtering residue and A operation decocting in water being extracted 2 hours again, filtration is taken off slag and is got liquid, is 1.08/80 ℃ standby extractum with being condensed into proportion the merging of twice gained filtrate.
Described Radix Angelicae Sinensis mixed powder is the fine powder based on particle diameter 10～150 μ m.
Described Radix Angelicae Sinensis mixed powder is the micropowder based on particle diameter 0.1-1.0 μ m.
Described Radix Angelicae Sinensis mixed powder is based on the nano powder of particle diameter less than 0.1 μ m.
Described Radix Angelicae Sinensis mixed powder is made up of two kinds of powders in fine powder, micropowder, three kinds of granule powders of nano powder at least.
A kind of preparation method for the treatment of medicine for gynecopathy according to above technical scheme proposition, obtained the manufacture method of the similar series of products of patent of invention compares with our company, its main feature has 4 points: the first is used as medicine the mixed powder of Radix Angelicae Sinensis with fine powder, fine powder and nanoscale micropowders, so both helped the abundant stripping of effective ingredient in the Radix Angelicae Sinensis medical material, and also helped the patient and absorb; It two is Herba Andrographis to be gone into medicinal by pulverizing in the past, changes into alcohol heating reflux (or percolation) and extracting, and makes extractum and is used as medicine; Its three, will adopt Radix Codonopsis to pulverize originally and be used as medicine, change decocting in water into, extract filtrate and make extractum and be used as medicine, both reduced the starch amount, help making full use of the aqueous soluble active constituent in the Radix Codonopsis again; Four, the medicinal residues that produce in the relevant technology are carried out once more decocting in water and extract, improve the medical material comprehensive utilization ratio.
The specific embodiment
Improve the preparation method of the medicine (FUKE QIANJIN PIAN) of later treatment gynaecopathia according to this innovation of technique scheme proposition, its prescription is still continued to use the prescription compatibility of ZL98112696.0 patent, promptly still by the Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, the common prescription of Caulis Spatholobi eight flavor Chinese crude drugs that respectively are Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis, Fructus Zanthoxyli Dissiti and 16 weight portions of 9 weight portions.
Concrete preparation method is as follows:
A, the Chinese crude drug Herba Andrographis chosen extracted with 85% alcohol heat reflux method filter, through reclaiming ethanol, and filtrate is condensed into proportion is 1.08/80 ℃ standby extractum, and medicinal residues are standby;
B, the Radix Codonopsis of choosing, Fructus Zanthoxyli Dissiti, Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, Caulis Spatholobi Six-element Chinese crude drug are put together and are placed extractor, and decocting in water extracted once in 2 hours, crossed leaching liquid; And the extraction again after 2 hours with this filtering residue and A operation Herba Andrographis medicinal residues merging decocting in water, filtration is taken off slag and is got filtrate; Twice gained filter rear filtrate is merged, and to be condensed into proportion be 1.08/80 ℃ standby extractum;
C, will in pulverizer, be ground into by the Radix Angelicae Sinensis that prescription is chosen based on the micron order of 0.1-1.0 μ m particle diameter and particle diameter mixed powder less than the nano-scale particle of 0.1 μ m, and by at least 95% the powder rate be left and taken standby;
The extractum mixing that D, the Radix Angelicae Sinensis powder that will obtain from C technology and two technologies of A, B are obtained is respectively granulated later on, and drying is made tablet patent medicine through tabletting, or makes capsule drug through fill.
Described Fructus Zanthoxyli Dissiti, Caulis Mahoniae two flavor Chinese crude drugs and Radix Rosae Laevigatae, very heavy group, Caulis Spatholobi, Radix Codonopsis four flavor Chinese crude drugs separate independent decocting in water extraction, and obtain standby extractum; And Radix Rosae Laevigatae, very heavy group, Caulis Spatholobi, Radix Codonopsis are placed extractor, decocting in water extracts once, cross leaching liquid, and after again the merging of the Herba Andrographis medicinal residues in this filtering residue and A operation decocting in water being extracted 2 hours again, filtration is taken off slag and is got liquid, is 1.08/80 ℃ standby extractum with being condensed into proportion the merging of twice gained filtrate.
Described Radix Angelicae Sinensis mixed powder is the fine powder based on particle diameter 10～150 μ m.
Described Radix Angelicae Sinensis mixed powder is the micropowder based on particle diameter 0.1-1.0 μ m.
Described Radix Angelicae Sinensis mixed powder is based on the nano powder of particle diameter less than 0.1 μ m.
Described Radix Angelicae Sinensis mixed powder is made up of two kinds of powders in fine powder, micropowder, three kinds of granule powders of nano powder at least.
Why the scientific research personnel of our company proposes once more for this innovation and the improvement that is used for the treatment of the medicine for gynecopathy production technology of FUKE QIANJIN PIAN, mainly based on two big reasons:
The one, along with the appearance of nanometer theory, herbal pharmaceutical is to being in the research of dependency relation between nanoscale, micron order drug particles and the drug effect;
The 2nd, this seminar person of having utilize the current paper data to this flavor Chinese medicine Chinese crude drug of Radix Codonopsis re-recognizing aspect the pharmacological properties.
Micron Chinese medicine and nanometer Chinese medicine are meant that adopting the modern high technology nanotechnology to combine with the process of preparing Chinese medicine of Chinese medicine tradition and preparation technique develops; can keep Chinese medicine to have pharmacodynamics material base, particle diameter to be respectively 0.1～10 μ m micron particles or particle diameter new medicine less than 0.1 μ m nano-scale particle.
Modern medicine is all thought material base that Chinese medicine prevents and cures diseases from biological activity position or active chemical components, and therefore, general traditional medicine scholar's attention mainly concentrates on to seek to be had on the various bioactive chemical compounds.But through the modern science personnel traditional Chinese medical science, Chinese medicine further investigation are shown: living organism is an extremely complex physical chemical process to absorption, metabolism, the drainage of medicine, the pharmacodynamics effect that Chinese medicine produces can not give the credit to the distinctive chemical composition of this medicine uniquely, and is also closely related with the physical state of medicine etc.Therefore, changing the physical state of medicine, is the raising drug effect, also is a kind of method that is worth trying to explore of development newtype drug.
From having had many scientific and technical personnel some Chinese crude drug to be changed the test of drug unit size (volume) the disclosed documents and materials at present, result of the test shows, change primary crude drug with distinct methods, make it to make the granularity difference, the biological activity of its medicine and availability all can be largely increased.Its reason is: the dissolution rate of medicine is directly proportional with the specific grain surface of medicine is long-pending, and this surface area and particle diameter are inversely proportional to.Therefore, the particle diameter of medicine is thin more, and its surface area is big more, helps the stripping of effective ingredient more.
Just be based on above-mentioned theory research and document foundation, medicine---the prescription characteristics of FUKE QIANJIN PIAN of the scientific research personnel of this seminar binding energy treatment gynaecopathia, proposition is to the Chinese medicine angelica in the raw material, processing particle diameter in flour mill proposes following requirement, and promptly the powder of 0.1-10 μ m and the following particle diameter of 0.1 μ m should account for more than 80% in fine powder after grinding and the fine powder.The result who so does not only makes the powder rate bring up to more than 95% from 93.3, has improved the medical material utilization rate; Also will in using because the dissolution of the active substance of Radix Angelicae Sinensis improves, and it is improved in the intravital bioavailability of patient, and can bring the raising of drug action.
In addition, why research worker of the present invention proposes: Radix Codonopsis is carried out decocting in water with Fructus Zanthoxyli Dissiti, Caulis Mahoniae, this five tastes medical material of Radix Flemingiae Philippinensis and Caulis Spatholobi extract, its reason has three:
One adopts methods such as water extraction, solvent extraction that Radix Codonopsis is carried out chemical analysis and studies show that Radix Codonopsis mainly contains polysaccharide according to relevant scholar, multiple tangshenoside, base-β-D glycoside, α-D-fructose ethanol glycoside etc. just; Sterols composition such as α-Bo sterol, stigmasterol etc.; Its main pharmacodynamics material is water-soluble components, extracts and can the main pharmacodynamics composition of Radix Codonopsis be extracted comparatively fully by decocting in water.Changing Radix Codonopsis into decocting in water from original pulverizing extracts, this is more to give full play to better, the more effective processing method that Radix Codonopsis acts in this treatment medicine for gynecopathy of FUKE QIANJIN PIAN, also is the technical foundation of further this prescription being carried out evaluation of pharmacology prescription and clinical evaluation.
Its two, FUKE QIANJIN PIAN dose excessive (three times on the one, a time 6), it is the one of the main reasons that causes the FUKE QIANJIN PIAN dose excessive that Radix Codonopsis is pulverized with starch, can reduce the starch amount after changing decocting in water into, and dose is reduced.
Three, at the pulverization process of existing FUKE QIANJIN PIAN production technology to Radix Codonopsis, existing Radix Codonopsis is pulverized processing method, must earlier Radix Codonopsis be wanted the drying operation, changes decocting in water into and can shorten processing link later on, reduce production costs; And out-of-date methods also have a defective in processing is pulverized, and dust is too big in the crushing process, and is unfavorable to environmental conservation, and after changing decocting in water into and extracting, working environment are improved.
For the be used as medicine change of processing method of Herba Andrographis,, not only can produce to pulverize to cause and produce a large amount of dust by leaf after the Herba Andrographis drying mainly due to handling Herba Andrographis with pulverizing the method for being used as medicine; And the effective medicinal ingredient in this dust that flies upward---andrographolide also runs off thereupon, and shows that through our experiment the content of the andrographolide of one of main medicinal ingredient is apparently higher than Herba Andrographis branch portion in the Folium Andrographis.Therefore after in the present invention Herba Andrographis being used instead alcohol heat reflux (or percolation) extraction, can not only obviously improve the production and processing environment, also can avoid effective ingredient loss in its medicine simultaneously, help strengthening drug effect.
In addition, why research worker of the present invention proposes that Fructus Zanthoxyli Dissiti, Caulis Mahoniae are separated decocting in water with Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, Caulis Spatholobi is extracted, and this is based on our the deep progress to the research and the test of prescription medicine galenic pharmacy.This five kinds of Chinese medicine, especially the first four traditional Chinese medicine in this prescription, their pharmacological action is: contain alkaloid-berberine hydrochloride in Caulis Mahoniae and the Fructus Zanthoxyli Dissiti, contain tannin in Radix Rosae Laevigatae and the Radix Flemingiae Philippinensis.Therefore, what of the berberine hydrochloride that extracts in these four kinds of medical materials, content of tannin not only can play an important role to drug effect, and to produce prescription all significant to further adjusting later on.
Testing program and result are as follows:
One group: Radix Rosae Laevigatae 150 grams, Radix Flemingiae Philippinensis 150 grams.
Two groups: Caulis Mahoniae 150 grams, Fructus Zanthoxyli Dissiti 84.4 grams.
Three groups: Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, each 150 gram of Caulis Mahoniae, Fructus Zanthoxyli Dissiti 84.4 grams.
Experimental implementation: the medical material of specified in packets is pressed into fragment, places 3 to boil and carry container respectively, add 6 times of decoctings and boil 2 times to the medical material amount, each 2 hours, filter, filtrate is condensed into dried cream and accurate the title quantitatively respectively, 3 parts of dried cream samples.
Keep sample: 3 parts of dried cream samples are also indicated accurate weight, and are standby.
Sample is denoted as: 3-1,3-2,3-3 (totally 3 increments).
Measure: the content of tannin in one group, the content of berberine hydrochloride in two groups, the content of tannin and berberine hydrochloride in three groups.The data rows following table:
Compatibility changes the test data table
| Label | Dried cream heavy (g) | Tannin | Berberine hydrochloride | Content of tannin | Content of berberine hydrochloride |
| 3-1 | 28.4612 | 23.60％ | / | 6.7168g | / |
| 3-2 | 9.5329 | / | 4.0475mg/g | / | 0.3858mg |
| 3-3 | 33.7912 | 9.800％ | 0.7845mg/g | 3.3115g | 0.2651mg |
Test shows: after the medical material of Radix Rosae Laevigatae, Radix Flemingiae Philippinensis (containing the tannin composition) and Caulis Mahoniae, Fructus Zanthoxyli Dissiti (containing alkaloid) adopts and separate and merges decoction and test, with Radix Rosae Laevigatae and Radix Flemingiae Philippinensis and Caulis Mahoniae, Fructus Zanthoxyli Dissiti separate boil separately get after, the content of its working substance tannin has increased by one times with respect to old merging decocting method; Equally, separately boil the berberine hydrochloride that from Caulis Mahoniae and Fructus Zanthoxyli Dissiti, obtains after getting and also increase by 45.5%.This result fully shows: this two classes medical material is unwell to close to be fried in shallow oil, and should separately decoct.
In this production method, medicinal residues and Caulis Mahoniae, Fructus Zanthoxyli Dissiti, Radix Flemingiae Philippinensis, Radix Rosae Laevigatae, Caulis Spatholobi, the Radix Codonopsis decocting in water extraction back medicinal residues of Herba Andrographis after alcohol reflux (or percolation) extracts are merged once more decocting in water and extract in addition; Be the utilization once more to above-mentioned these medical materials, also make the more abundant extraction of aqueous soluble active constituent in the Herba Andrographis medical material, this is undoubtedly a kind of effective means to making full use of of medicine source.
Claims (6)
1, a kind of preparation method for the treatment of the medicine of gynaecopathia, it is made by Radix Codonopsis, Fructus Zanthoxyli Dissiti, Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, Caulis Spatholobi, Radix Angelicae Sinensis, Herba Andrographis, it is characterized in that preparing as follows:
A, the Chinese crude drug 9 weight portion Herba Andrographis chosen are extracted with alcohol heat reflux method or alcohol percolation method filter, through reclaiming ethanol, and filtrate is condensed into proportion is 1.08/80 ℃ standby extractum, and medicinal residues are standby;
B, the 9 weight portion Radix Codonopsis that will choose, 9 weight portion Fructus Zanthoxyli Dissiti, 16 weight portion Caulis Mahoniaes, 16 weight portion Radix Rosae Laevigataes, 16 weight portion Radix Flemingiae Philippinensiss, 16 weight portion Caulis Spatholobi Six-element Chinese crude drugs are put together and are placed extractor, and decocting in water extracted once in 2 hours, crossed leaching liquid; And this filtering residue and A operation Herba Andrographis medicinal residues are merged decocting in water extract 2 hours after-filtration again and take off slag and get filtrate; Twice gained filter rear filtrate is merged, and to be condensed into proportion be 1.08/80 ℃ standby extractum;
C, will in pulverizer, be ground into by the 9 weight portion Radix Angelicae Sinensis that prescription is chosen based on the micron order of 0.1-1.0 μ m particle diameter and particle diameter mixed powder less than the nano-scale particle of 0.1 μ m, and by at least 95% the powder rate be left and taken standby;
The extractum mixing that D, the Radix Angelicae Sinensis powder that will obtain from C technology and two technologies of A, B are obtained is respectively granulated later on, and drying is made tablet patent medicine through tabletting, or makes capsule drug through fill.
2, a kind of preparation method for the treatment of the medicine of gynaecopathia as claimed in claim 1, it is characterized in that: described Fructus Zanthoxyli Dissiti, Caulis Mahoniae two flavor Chinese crude drugs and Radix Rosae Laevigatae, very heavy group, Caulis Spatholobi, Radix Codonopsis four flavor Chinese crude drugs separate independent decocting in water extraction, and obtain standby extractum; And Radix Rosae Laevigatae, very heavy group, Caulis Spatholobi, Radix Codonopsis are placed extractor, decocting in water extracts once, cross leaching liquid, and again the merging of the Herba Andrographis medicinal residues in this filtering residue and A operation decocting in water is extracted after 2 hours again, filtration is taken off slag and is got liquid, is 1.08/80 ℃ standby extractum with being condensed into proportion the merging of twice gained filtrate.
3, a kind of preparation method for the treatment of the medicine of gynaecopathia as claimed in claim 1 is characterized in that: described Radix Angelicae Sinensis mixed powder is the fine powder based on particle diameter 10～150 μ m.
4, a kind of preparation method for the treatment of the medicine of gynaecopathia as claimed in claim 1 is characterized in that: described Radix Angelicae Sinensis mixed powder is the micropowder based on particle diameter 0.1-1.0 μ m.
5, a kind of preparation method for the treatment of the medicine of gynaecopathia as claimed in claim 1 is characterized in that: described Radix Angelicae Sinensis mixed powder is based on the nano powder of particle diameter less than 0.1 μ m.
6, a kind of preparation method for the treatment of the medicine of gynaecopathia as claimed in claim 1 is characterized in that: described Radix Angelicae Sinensis mixed powder, form by at least two kinds of powders in fine powder, micropowder, three kinds of granule powders of nano powder.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100233205A CN1296073C (en) | 2004-06-18 | 2004-06-18 | Method for preparing a gynecopathy treating medicine |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2004100233205A CN1296073C (en) | 2004-06-18 | 2004-06-18 | Method for preparing a gynecopathy treating medicine |
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| CN1593519A CN1593519A (en) | 2005-03-16 |
| CN1296073C true CN1296073C (en) | 2007-01-24 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10329316B2 (en) | 2016-03-17 | 2019-06-25 | Qianjin Pharmaceutical Co., Ltd. | Phenylpropanoid compound and preparation method and use thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109718296A (en) * | 2017-10-31 | 2019-05-07 | 株洲千金药业股份有限公司 | A kind of warm nest patch of analgesic antiphlogistic |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1298731A (en) * | 1999-12-07 | 2001-06-13 | 株洲千金药业股份有限公司 | Process for preparing 'Qianjin' capsule to treat ganopathy |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1298731A (en) * | 1999-12-07 | 2001-06-13 | 株洲千金药业股份有限公司 | Process for preparing 'Qianjin' capsule to treat ganopathy |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10329316B2 (en) | 2016-03-17 | 2019-06-25 | Qianjin Pharmaceutical Co., Ltd. | Phenylpropanoid compound and preparation method and use thereof |
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| CN1593519A (en) | 2005-03-16 |
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