CN1298731A - Process for preparing 'Qianjin' capsule to treat ganopathy - Google Patents
Process for preparing 'Qianjin' capsule to treat ganopathy Download PDFInfo
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- CN1298731A CN1298731A CN 99115683 CN99115683A CN1298731A CN 1298731 A CN1298731 A CN 1298731A CN 99115683 CN99115683 CN 99115683 CN 99115683 A CN99115683 A CN 99115683A CN 1298731 A CN1298731 A CN 1298731A
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- caulis
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- angelicae sinensis
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Abstract
A qianjin capsule for treating gynaecopathia is made up from euphorbiae lathyridis, radix rosae laevigatae, herba andrographitis, radix angelicae sinensis, caulis mahoniae, caulis sphatholobi and radix codonopsis pilosulae as raw materials, and is prepared as follows: extract herba andrographitis and radix angelicaa sinesis using ethyl alcohol by heating and reflux method and concentrate into clear paste: decoct caulis mahoniae and danmianzhen twice and concentrate in to clear paste; decoct euphorbiae lathyridis, radix rosae leaevigatae, caulis spatholobi and radix codonopsis pilosulae and filter, concentrate into clear paste, mix all pastes uniformly, spray-dried, and then pelletize and fill to obtain capsule.
Description
The present invention relates to a kind of manufacture method of FUKE QIANJIN JIAONANG, belong to Chinese medicinal capsule manufacturing process class.
China's Chinese medicine generally all adopts decoction, pill, powder etc.; Later on along with agent has appearred again in society's science and technology, economic progress.FUKE QIANJIN PIAN is to be raw material with very heavy group of Chinese crude drug, Herba Andrographis, Radix Angelicae Sinensis, Caulis Mahoniae, Fructus Zanthoxyli Dissiti, Radix Rosae Laevigatae, Caulis Spatholobi and Radix Codonopsis, through the tablet form compound Chinese patent medicine of selecting materials, pulverizing, operation such as granulation, coating being made.Clinical practice through has for many years shown that it is a kind of good medicine that is applicable to a kind of valency health thing U.S. of gynaecopathias such as woman uterus inflammation, urgent chronic pelvic inflammatory disease, endometritis, menoxenia, leucorrhoea grow in quantity really.
The Chinese patent medicine FUKE QIANJIN PIAN is a kind of rare gynecological's good medicine, but it still exists some pop-offs of Chinese patent medicine tablet: dose is bigger, will eat 6 at every turn; Patient is when taking this tablet, though eaten into the effective ingredient that it works the effect of curing the disease, the adjuvant of in fact also having eaten into fiber such as quite a few plant roots that contains these medicine active ingredients, stem, leaf and invalid element simultaneously and having added in production process.Patient is after taking medicine, and some effective ingredient can not fully be digested and assimilated and excrete thereupon by the intestines and stomach; And patient is after taking medicine, and tablet disintegration time under one's belt is long, it is slow or the like to take effect.So how to improve the bioavailability of Chinese medicine, active ingredient is fully extracted, improving curative effect of medication is the developing direction of Chinese patent medicine, capsule then is one of its correct selection path.
Purpose of the present invention aims to provide the requirement of a kind of adaptation FUKE QIANJIN PIAN compatibility, can make the FUKE QIANJIN JIAONANG production method of its performance optimum curative effect.
This is the FUKE QIANJIN JIAONANG of compatibility by very heavy group of Chinese crude drug, Radix Rosae Laevigatae, Herba Andrographis, Radix Angelicae Sinensis, Caulis Mahoniae, Fructus Zanthoxyli Dissiti, Caulis Spatholobi and Radix Codonopsis, and its manufacture method is:
A, at first Herba Andrographis and Radix Angelicae Sinensis one are reinstated ethanol and extracted through heating reflux method and filter, reclaim ethanol, and filtrate is condensed into clear paste;
B, secondly be that Caulis Mahoniae, Fructus Zanthoxyli Dissiti decocting in water are extracted, filter and filtrate is condensed into clear paste after taking off slag;
C, very heavy group, Radix Rosae Laevigatae, Caulis Spatholobi, Radix Codonopsis decocting in water are extracted, filter and take off slag and get filtrate, and this filtering residue and A operation gained Herba Andrographis, Radix Angelicae Sinensis filtering residue merging decocting in water are extracted again; The merging of twice gained filter rear filtrate is condensed into clear paste;
D, merge above-mentioned three kinds of clear paste through mixing-spray drying-granulation-fill four procedures FUKE QIANJIN JIAONANG.
FUKE QIANJIN JIAONANG according to said method production, compare with present FUKE QIANJIN PIAN, its advantage is the relative enrichment of active ingredient that makes in the medical material, improve content, eliminate former mix and be contained in the invalid thing in the Herba Andrographis and Radix Angelicae Sinensis in the FUKE QIANJIN PIAN, patient's drug administration amount is reduced, improve curative effect, instant effect.
Below provide embodiment, and further set forth the present invention in conjunction with the embodiments:
Prescription according to the compound women's QIANJIN PIAN: the incorporation of Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis and Fructus Zanthoxyli Dissiti respectively is 9% of a medical material gross weight; The incorporation of Radix Rosae Laevigatae, Caulis Spatholobi, Caulis Mahoniae and Radix Flemingiae Philippinensis respectively is 16% of a medical material total amount
Then according to above-mentioned process, at first Herba Andrographis and Radix Angelicae Sinensis are extracted both active ingredients through heating reflux method with the ethanol of 85% concentration, filtration is taken off slag and is obtained the filtrate that ethanol is solvent later on, and concentrated filtrate obtains to contain the effect clear paste of curing the disease in Herba Andrographis and the Radix Angelicae Sinensis after reclaiming ethanol.
Secondly respectively with Caulis Mahoniae, Fructus Zanthoxyli Dissiti, and very heavy group, Radix Rosae Laevigatae, Caulis Spatholobi, Radix Codonopsis decocting in water respectively, take off slag and obtain corresponding filtrate through extracting, filtering; Wherein the filtrate of Caulis Mahoniae and Fructus Zanthoxyli Dissiti directly is condensed into clear paste.And extract again staying behind very heavy group, Radix Rosae Laevigatae, Caulis Spatholobi, Radix Codonopsis decocting in water; With concentrated the third clear paste of making of this extracting solution and extracting solution merging for the first time.
The most above-mentioned three kinds of clear paste merge after the mixing, spray-dried, granulation, fill operation the alleged FUKE QIANJIN JIAONANG of the present invention.
In above-mentioned operation, what really play effect is that above-mentioned all medical materials are adopted the method for extracting of handling respectively; Experiment through this programme inventor: adopt the difference decocting in water extracting method of Radix Rosae Laevigatae, Radix Flemingiae Philippinensis and Caulis Mahoniae and Fructus Zanthoxyli Dissiti, extract than decocting in water that above-mentioned four kinds of medical materials are mixed, the content of tannin and berberine exceeds 2.5～5 times respectively in its filtrate.
The result shows through zoopery: FUKE QIANJIN JIAONANG all has the obvious suppression effect to rat paw edema due to Oleum Tiglii induced mice ear swelling, the chondrus ocellatus Holmes and rat cotton balls granuloma.The rat uterus inflammation is also had good inhibitory action, and the effect of capsule sheet is better than tablet.FUKE QIANJIN JIAONANG can be resisted the capillary permeability increase effect of acetic acid induced mice abdominal cavity, and the type blood deficiency mice that loses blood is had tangible blood tonification effect, can also resist the immune function of mice reduction that cyclophosphamide causes.Extracorporeal bacteria inhibitor test is the result show: to 9 kinds of antibacterials such as escherichia coli the clinical separation of totally 95 strains cause bacterium and have certain bacteriostasis.To the coli-infection mice, high dose has the certain protection effect, and the capsule effect slightly is better than tablet.
The clinical application observe the curative effect is as follows:
Through No. 1 Hospital Affiliated to Hunan Traditional Chinese Medical College, Hunan Province woman keep healthy institute, Hunan Province Affiliated Hospital of the academy of traditional Chinese medicine from March, 1998～1998 year November to 381 routine women's chronic pelvic inflammatory diseases, chronic endometritis, chronic cervicitis patient, adopt FUKE QIANJIN PIAN, FUKE QIANJIN JIAONANG, three kinds of medicines of JINJI PIAN to treat, test group (FUKE QIANJIN JIAONANG group) 161 examples wherein, matched group (FUKE QIANJIN PIAN group) 100 examples; Chronic palace intimitis 60 examples, wherein each 30 example of test group (FUKE QIANJIN JIAONANG group) and matched group (FUKE QIANJIN PIAN group); Chronic cervicitis 60 examples, wherein each 30 example of test group (FUKE QIANJIN JIAONANG group) and matched group (FUKE QIANJIN PIAN group).And with state of an illness integrated value judgement curative effect before and after the treatment.
The result shows: the total obvious effective rate of (1) FUKE QIANJIN JIAONANG treatment chronic pelvic inflammatory disease, total effective rate are respectively 80.12%, 98.75%; Treat the total obvious effective rate of chronic palace intimitis, total effective rate is respectively 100%, 100%; The total obvious effective rate of treatment chronic cervicitis, total effective rate are respectively 33.3%, 96.7%; Its determined curative effect is better than FUKE QIANJIN PIAN sheet group; The medicine of (2) two kinds of dosage forms all has the effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, benefiting qi and nourishing blood, strong waist and nourishing kidney, and chronic pelvic inflammatory disease, chronic palace intimitis, chronic cervicitis patient are all had better curative effect.(3) FUKE QIANJIN JIAONANG is lacked than the QIANJIN PIAN consumption, and it is more convenient to take medicine, and welcome by patient and clinician; (4) FUKE QIANJIN JIAONANG drug safety is not seen toxic and side effects and untoward reaction in the observation process.
Clinical application shows: FUKE QIANJIN PIAN and FUKE QIANJIN JIAONANG curative effect obviously are better than JINJI PIAN, and the FUKE QIANJIN JIAONANG curative effect is better than FUKE QIANJIN PIAN.Really reach final goal of the present invention.
Claims (1)
1, a kind of is the FUKE QIANJIN JIAONANG of compatibility by Chinese crude drug Radix Flemingiae Philippinensis, Radix Rosae Laevigatae, Herba Andrographis, Radix Angelicae Sinensis, Caulis Mahoniae, Fructus Zanthoxyli Dissiti, Caulis Spatholobi and Radix Codonopsis, and its processing technology is:
A, at first Herba Andrographis Radix Angelicae Sinensis one is reinstated ethanol and extract to be filtered, reclaim ethanol, and filtrate is condensed into clear paste through heating reflux method;
B, secondly be that Caulis Mahoniae, Fructus Zanthoxyli Dissiti decocting in water are extracted, filter and filtrate is condensed into clear paste after taking off slag;
C, very heavy group, Radix Rosae Laevigatae, Caulis Spatholobi, Radix Codonopsis decocting in water are extracted, filter and take off slag and get filtrate, and after the filtering residue of this filtering residue and A operation gained Herba Andrographis and Radix Angelicae Sinensis merged decocting in water and extract, with the merging of twice gained filter rear filtrate, and concentrated clear paste;
D, merge above-mentioned three kinds of clear paste, through mixing-spray drying-granulation-fill four procedures the finished product FUKE QIANJIN JIAONANG.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB991156838A CN1158087C (en) | 1999-12-07 | 1999-12-07 | Process for preparing 'Qianjin' capsule to treat ganopathy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB991156838A CN1158087C (en) | 1999-12-07 | 1999-12-07 | Process for preparing 'Qianjin' capsule to treat ganopathy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1298731A true CN1298731A (en) | 2001-06-13 |
| CN1158087C CN1158087C (en) | 2004-07-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB991156838A Expired - Lifetime CN1158087C (en) | 1999-12-07 | 1999-12-07 | Process for preparing 'Qianjin' capsule to treat ganopathy |
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| CN (1) | CN1158087C (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1296072C (en) * | 2004-06-18 | 2007-01-24 | 株洲千金药业股份有限公司 | Method for preparing a gynecopathy treating medicine |
| CN1296071C (en) * | 2004-06-18 | 2007-01-24 | 株洲千金药业股份有限公司 | Method for preparing a gynecopathy treating medicine |
| CN1296073C (en) * | 2004-06-18 | 2007-01-24 | 株洲千金药业股份有限公司 | Method for preparing a gynecopathy treating medicine |
| CN1310639C (en) * | 2004-11-25 | 2007-04-18 | 张平 | Effervescence tablet for treating gynecopathy and preparation method thereof |
| CN1318055C (en) * | 2004-12-03 | 2007-05-30 | 仁和（集团）发展有限公司 | Method for preparing medicine |
| CN1318054C (en) * | 2004-08-26 | 2007-05-30 | 仁和（集团）发展有限公司 | Prepn process of medicine for treating gynecopathy |
| CN1321631C (en) * | 2004-06-18 | 2007-06-20 | 株洲千金药业股份有限公司 | Method for preparing a gynecopathy treating medicine |
| CN1330335C (en) * | 2004-06-18 | 2007-08-08 | 株洲千金药业股份有限公司 | Method for preparing a gynecopathy treating medicine |
| CN106650197A (en) * | 2016-08-12 | 2017-05-10 | 株洲千金药业股份有限公司 | PPK-PPD model establishing method for combination of Chinese and Western medicine and evaluation application for combination of Fukeqianjinfang composition and azithromycin |
| CN107080817A (en) * | 2017-05-04 | 2017-08-22 | 上海市静安区芷江西路街道社区卫生服务中心 | A kind of Novel gynecology-department a thousand pieces of gold oil of zedoary turmeric bolt |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017157260A1 (en) | 2016-03-17 | 2017-09-21 | 株洲千金药业股份有限公司 | Phenylpropanoid and preparation method and application thereof |
-
1999
- 1999-12-07 CN CNB991156838A patent/CN1158087C/en not_active Expired - Lifetime
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1296072C (en) * | 2004-06-18 | 2007-01-24 | 株洲千金药业股份有限公司 | Method for preparing a gynecopathy treating medicine |
| CN1296071C (en) * | 2004-06-18 | 2007-01-24 | 株洲千金药业股份有限公司 | Method for preparing a gynecopathy treating medicine |
| CN1296073C (en) * | 2004-06-18 | 2007-01-24 | 株洲千金药业股份有限公司 | Method for preparing a gynecopathy treating medicine |
| CN1321631C (en) * | 2004-06-18 | 2007-06-20 | 株洲千金药业股份有限公司 | Method for preparing a gynecopathy treating medicine |
| CN1330335C (en) * | 2004-06-18 | 2007-08-08 | 株洲千金药业股份有限公司 | Method for preparing a gynecopathy treating medicine |
| CN1318054C (en) * | 2004-08-26 | 2007-05-30 | 仁和（集团）发展有限公司 | Prepn process of medicine for treating gynecopathy |
| CN1310639C (en) * | 2004-11-25 | 2007-04-18 | 张平 | Effervescence tablet for treating gynecopathy and preparation method thereof |
| CN1318055C (en) * | 2004-12-03 | 2007-05-30 | 仁和（集团）发展有限公司 | Method for preparing medicine |
| CN106650197A (en) * | 2016-08-12 | 2017-05-10 | 株洲千金药业股份有限公司 | PPK-PPD model establishing method for combination of Chinese and Western medicine and evaluation application for combination of Fukeqianjinfang composition and azithromycin |
| CN106650197B (en) * | 2016-08-12 | 2019-09-20 | 株洲千金药业股份有限公司 | Chinese and Western is combined drug PPK-PPD method for establishing model and gynaecology's prescriptions worth thousand gold composition and azithromycin combination evaluation application |
| CN107080817A (en) * | 2017-05-04 | 2017-08-22 | 上海市静安区芷江西路街道社区卫生服务中心 | A kind of Novel gynecology-department a thousand pieces of gold oil of zedoary turmeric bolt |
| CN107080817B (en) * | 2017-05-04 | 2020-05-12 | 上海市静安区芷江西路街道社区卫生服务中心 | Novel gynecological Qianjin zedoary turmeric oil suppository |
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| Publication number | Publication date |
|---|---|
| CN1158087C (en) | 2004-07-21 |
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