CN1171624C - Method for preparing Chinese medicine Liuwei Dihuang preparation - Google Patents
Method for preparing Chinese medicine Liuwei Dihuang preparation Download PDFInfo
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- CN1171624C CN1171624C CNB021341001A CN02134100A CN1171624C CN 1171624 C CN1171624 C CN 1171624C CN B021341001 A CNB021341001 A CN B021341001A CN 02134100 A CN02134100 A CN 02134100A CN 1171624 C CN1171624 C CN 1171624C
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- poria
- cortex moutan
- fructus corni
- thick paste
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Abstract
The present invention relates to a method for producing a Chinese medicine Liuwei Dihuang preparation. The method is characterized in that prepared rehmannia roots, dogwood, cortex moutan radices, Chinese yams, tuckahoe and water plantains are respectively processed in different modes of pulverization, water action, alcohol extraction, etc. to extract effective ingredients, and the effective ingredients are uniformly mixed to prepare preparations, such as capsule, granules, tablets, etc. Compared with the prior art, the present invention improves reasonably the traditional technology; proved by clinical verification, the Chinese medicine Liuwei Dihuang preparation has conspicuous curative effect, dosage is reduced, and the taking by patients is facilitated; the same effect can be obtained by taking two granules in placing of taking originally eight granules. By means of the method, the contents of medicines of ursolic acid or paeonol which plays an important role in medicines can be detected in the process of production; thus, the quality of the medicines can be raised, and the integral quality of Chinese medicines can be scientifically raised.
Description
Technical field: the present invention is a kind of production method of Chinese medicine Liuwei Dihuang preparation, belongs to the field of the production technology of medicine.
Technical background: the Chinese medicine six drugs containing rehmanniae is a kind of common drug, and main effect is enriching yin and nourishing kidney, is used for damage of kidney-YIN, dizziness and tinnitus, soreness of the waist and knees, osteopyrexia and fever, night sweat seminal emission, symptom such as quench one's thirst; More representational in the method for medicine Liuwei Dihuang preparation aborning is to adopt the method for putting down in writing on the existing ministry standard, it is that the flavor of three in Six-element Chinese medicine Fructus Corni, Cortex Moutan, Poria powder are broken into powder, again remaining three flavor water decocted, concentrate the solution that obtains then and become cream, cream with after the powdered drug that obtains mixes medicine, also can be made into pill during medicine can incapsulate; Contain a large amount of invalid elements and impurity in the medicine medicine that this method obtains,, bring psychological pressure and uneasiness to the patient like this, and take inconvenience so when using, need take a lot of dosage; Chinese patent communique 00109681.8 discloses a kind of " preparation method of Chinese patent medicine novel form and reform thereof "; This invention adds water with all raw medicinal materials and carries out heating extraction, obtains extractum after extracting solution is concentrated, and with medicinal residues oven dry, pulverizing, extractum that obtains and medicinal residues fine powder mix homogeneously, makes granular medicine with spray-dired method again; After deliberation, in the six medicaments that constitutes this medicine of Chinese medicine six drugs containing rehmanniae, in Cortex Moutan, contain paeonol, in Fructus Corni, contain ursolic acid, paeonol and ursolic acid all are the compositions that have important effect in this medicine, paeonol is a volatile component in addition, if the heating decocting in water then volatilizees, and ursolic acid is water insoluble, be soluble in alcohol, so simple water boiling method, can not extract ursolic acid, so adopt existing two kinds of methods or can make the active ingredient volatilization of medicine and go, the active ingredient loss is big especially, make medicine can not propose active ingredient, so the Chinese medicine six drugs containing rehmanniae that existing method is produced needs the patient to take in a large number, to solve the unfavorable problem of drug effect.
Summary of the invention: the objective of the invention is to: the production method that a kind of Chinese medicine Liuwei Dihuang preparation is provided, this method has taken into full account the paeonol tool volatility characteristics in the Cortex Moutan, if heating decocting in water water then volatilizees, and the ursolic acid in the Fructus Corni is water insoluble, only be dissolved in pure characteristics, adopting targetedly, method extracts the active ingredient in the Six-element crude drug fully, the Chinese medicine Liuwei Dihuang preparation of producing is owing to have the advantages that active ingredient is concentrated, so its curative effect is remarkable especially, according to state-promulgated pharmacopoeia
The suggestion of committee is, takes 8 amount by original needs and is reduced to and only need takes 2, just can reach effect same.The present invention constitutes like this: Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis are made according to following method: an amount of Poria powder is broken into fine powder, sieves; Fructus Corni adds alcohol reflux, filtration, filtrate and is concentrated into the thick paste shape, the Cortex Moutan vapor distillation with the distillate crystallization, decocts with water aqueous solution and Cortex Moutan medicinal residues, Fructus Corni medicinal residues, remaining Poria and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis after the distillation, the aqueous solution that obtains filters, merging filtrate is concentrated into the thick paste shape, adds the Fructus Corni thick paste that has become ground Poria and obtained again, mix homogeneously, drying, be ground into fine powder, add the extract of Cortex Moutan at last, mix homogeneously; Specifically: Radix Rehmanniae Preparata 1408 grams, Fructus Corni 704 grams, Cortex Moutan 528 grams, Rhizoma Dioscoreae 704 grams, Poria 528 grams, Rhizoma Alismatis 528 grams are made according to following method: get Poria 350 grams and be ground into fine powder, sieve; Fructus Corni adds alcohol reflux twice, each 1 hour, filter, filtrate is concentrated into the thick paste shape, medicinal residues are standby, the Cortex Moutan vapor distillation, with the distillate crystallization, aqueous solution and the Cortex Moutan medicinal residues after the distillation, the Fructus Corni medicinal residues, remaining Poria and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis decocts with water three times, each 1 hour, filter, merging filtrate, be concentrated into the thick paste shape, add the Fructus Corni thick paste that has become ground Poria and obtained, mix homogeneously again, adopt cold drying, be ground into fine powder, add the extract of Cortex Moutan at last, add an amount of adjuvant, can make different preparations behind the mix homogeneously.
Compared with prior art: the present invention is reasonable to the improvement of traditional handicraft, drug effect and clinical verification proof are evident in efficacy, reduced dose, facilitate patients, suggestion according to Chinese Pharmacopoeia Commission's [pharmacopeia is already sent out (1999) No. 184] literary composition is: " take 8 amount by original needs and be reduced to and only need take 2, just can reach effect same ".Particularly, utilize method provided by the invention, can improve the quality of medicine like this, the total quality of the lifting Chinese medicine of science by ursolic acid or this content of medicines that plays a crucial role of paeonol are detected in process of production in medicine.
Embodiments of the invention 1: select Radix Rehmanniae Preparata 1408 grams, Fructus Corni 704 grams, Cortex Moutan 528 grams, Rhizoma Dioscoreae 704 grams, Poria 528 grams, Rhizoma Alismatis 528 grams to make: to get Poria 350 grams and be ground into fine powder, sieve according to following method; Fructus Corni adds alcohol reflux twice, each 1 hour, filter, filtrate is concentrated into the thick paste shape, medicinal residues are standby, the Cortex Moutan vapor distillation is with the distillate crystallization, aqueous solution and the Cortex Moutan medicinal residues after the distillation, the Fructus Corni medicinal residues, remaining Poria and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis decocts with water three times, each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, adds the Fructus Corni thick paste that has become ground Poria and obtained again, mix homogeneously, adopt cold drying, be ground into fine powder, add the extract of Cortex Moutan at last, add an amount of adjuvant, incapsulate behind the mix homogeneously, can get 2000 LIUWEIDIHUANG JIAONANG.
Embodiments of the invention 2: select Radix Rehmanniae Preparata 1408 grams, Fructus Corni 704 grams, Cortex Moutan 528 grams, Rhizoma Dioscoreae 704 grams, Poria 528 grams, Rhizoma Alismatis 528 grams to make: to get Poria 350 grams and be ground into fine powder, sieve according to following method; Fructus Corni added alcohol reflux 1 hour, filter, filtrate is concentrated into the thick paste shape, medicinal residues are standby, the Cortex Moutan vapor distillation, with the distillate crystallization, aqueous solution and the Cortex Moutan medicinal residues after the distillation, the Fructus Corni medicinal residues, remaining Poria and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis decocts with water secondary, each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, add the Fructus Corni thick paste that has become ground Poria and obtained again, mix homogeneously adopts conventional drying, is ground into fine powder, the extract that adds Cortex Moutan at last adds an amount of adjuvant, make ball behind the mix homogeneously.
Embodiments of the invention 3: Radix Rehmanniae Preparata 1408 grams, Fructus Corni 704 grams, Cortex Moutan 528 grams, Rhizoma Dioscoreae 704 grams, Poria 528 grams, Rhizoma Alismatis 528 grams are made according to following method: the Poria powder of half is broken into fine powder, sieves; Fructus Corni adds alcohol reflux, filtration, filtrate and is concentrated into the thick paste shape, the Cortex Moutan vapor distillation, with the distillate crystallization, aqueous solution and Cortex Moutan medicinal residues, Fructus Corni medicinal residues, remaining Poria and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis after the distillation are decocted with water, the aqueous solution that obtains filters, merging filtrate, be concentrated into the thick paste shape, add the Fructus Corni thick paste that has become ground Poria and obtained again, mix homogeneously adopts cold drying, be ground into fine powder, the extract that adds Cortex Moutan at last, mix homogeneously can be made preparations such as granulating, sheet.
Embodiments of the invention 4: select Radix Rehmanniae Preparata 176 grams, Fructus Corni 88 grams, Cortex Moutan 66 grams, Rhizoma Dioscoreae 88 grams, Poria 66 grams, Rhizoma Alismatis 66 grams to make: to get Poria 30 grams and be ground into fine powder, sieve according to following method; Fructus Corni adds alcohol reflux twice, each 1 hour, filter, filtrate is concentrated into the thick paste shape, medicinal residues are standby, the Cortex Moutan vapor distillation, with the distillate crystallization, aqueous solution and the Cortex Moutan medicinal residues after the distillation, the Fructus Corni medicinal residues, remaining Poria and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis decocts with water three times, each 1 hour, filter, merging filtrate, be concentrated into the thick paste shape, add the Fructus Corni thick paste that has become ground Poria and obtained, mix homogeneously again, adopt normal temperature drying, be ground into fine powder, add the extract of Cortex Moutan at last, add an amount of adjuvant, make granule behind the mix homogeneously.
Claims (2)
1, the production method of Chinese medicine Liuwei Dihuang preparation, it is characterized in that: Radix Rehmanniae Preparata 1408 grams, Fructus Corni 704 grams, Cortex Moutan 528 grams, Rhizoma Dioscoreae 704 grams, Poria 528 grams, Rhizoma Alismatis 528 grams are made according to following method: 350 gram Poria powders are broken into fine powder, sieve; Fructus Corni adds alcohol reflux, filtration, filtrate and is concentrated into the thick paste shape, the Cortex Moutan vapor distillation with the distillate crystallization, decocts with water aqueous solution and Cortex Moutan medicinal residues, Fructus Corni medicinal residues, remaining Poria and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis after the distillation, the aqueous solution that obtains filters, merging filtrate is concentrated into the thick paste shape, adds the Fructus Corni thick paste that has become ground Poria and obtained again, mix homogeneously, drying, be ground into fine powder, add the extract of Cortex Moutan at last, mix homogeneously.
2, according to the production method of the described this Chinese medicine Liuwei Dihuang preparation of claim 1, it is characterized in that: Radix Rehmanniae Preparata 1408 grams, Fructus Corni 704 grams, Cortex Moutan 528 grams, Rhizoma Dioscoreae 704 grams, Poria 528 grams, Rhizoma Alismatis 528 grams are made according to following method: get Poria 350 grams and be ground into fine powder, sieve; Fructus Corni adds alcohol reflux twice, each 1 hour, filter, filtrate is concentrated into the thick paste shape, medicinal residues are standby, the Cortex Moutan vapor distillation, with the distillate crystallization, aqueous solution and the Cortex Moutan medicinal residues after the distillation, the Fructus Corni medicinal residues, remaining Poria and Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis decocts with water three times, each 1 hour, filter, merging filtrate, be concentrated into the thick paste shape, add the Fructus Corni thick paste that has become ground Poria and obtained, mix homogeneously again, adopt cold drying, be ground into fine powder, add the extract of Cortex Moutan at last, add an amount of adjuvant, can make different preparations behind the mix homogeneously.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021341001A CN1171624C (en) | 2002-11-15 | 2002-11-15 | Method for preparing Chinese medicine Liuwei Dihuang preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB021341001A CN1171624C (en) | 2002-11-15 | 2002-11-15 | Method for preparing Chinese medicine Liuwei Dihuang preparation |
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| CN1413697A CN1413697A (en) | 2003-04-30 |
| CN1171624C true CN1171624C (en) | 2004-10-20 |
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| CNB021341001A Expired - Fee Related CN1171624C (en) | 2002-11-15 | 2002-11-15 | Method for preparing Chinese medicine Liuwei Dihuang preparation |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167923B (en) * | 2007-10-31 | 2010-10-27 | 兰州卷烟厂 | Preparation of six ingredients with rehmannia and its application in cigarette |
| CN102319333A (en) * | 2011-05-19 | 2012-01-18 | 大连九羊食品有限公司 | Sheep liver eyesight improving pill and processing method thereof |
| CN102309660A (en) * | 2011-05-19 | 2012-01-11 | 大连九羊食品有限公司 | Traditional Chinese medicine (TCM) oral liquid containing sheep placenta and processing method thereof |
| CN102309659A (en) * | 2011-05-19 | 2012-01-11 | 大连九羊食品有限公司 | Traditional Chinese medicine (TCM) capsule containing sheep placenta and processing method thereof |
| CN102526378B (en) * | 2012-02-16 | 2017-05-10 | 佳木斯大学 | Application of tree peony bark-barbary wolfberry fruit particles to preparation of hypoglycemic medicament |
| CN103948772A (en) * | 2014-05-20 | 2014-07-30 | 王庚禹 | Extract for preparing kidney-qi-tonifying preparation |
| CN104000994A (en) * | 2014-06-06 | 2014-08-27 | 余中华 | Preparation method of concentrated six-taste glutinous rehmannia capsule |
| CN106214911A (en) * | 2016-08-22 | 2016-12-14 | 湖南康尔佳制药股份有限公司 | A kind of medicine of enriching yin and nourishing kidney and preparation method thereof |
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Effective date of registration: 20030221 Applicant after: Ma Cuiping Applicant before: Guizhou Kangna Shengfang Pharmaceutical Co.,Ltd. |
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Owner name: KANG GUOZHONG Free format text: FORMER OWNER: MA CUIPING Effective date: 20041029 |
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Effective date of registration: 20041029 Address after: 550001 No. 4, unit 44, 7, one half street, Yunyan District, Guizhou, Guiyang Patentee after: Kang Guozhong Address before: 550001 Guiyang new patent office, Yanan East Road, 33, Guizhou, Guiyang Patentee before: Ma Cuiping |
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Decision date of declaring invalidation: 20060816 Decision number of declaring invalidation: 8566 |
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