CN1060663C

CN1060663C - Compound Tibet capillary artemisia patent medicine

Info

Publication number: CN1060663C
Application number: CN96105691A
Authority: CN
Inventors: 郭振昌; 李风
Original assignee: Individual
Current assignee: Individual
Priority date: 1996-05-10
Filing date: 1996-05-10
Publication date: 2001-01-17
Anticipated expiration: 2016-05-10
Also published as: CN1156602A

Abstract

The present invention relates to a compound formula patent medicine which takes Tibet herba artemisiae as main medicine and is characterized in that (1). the formula is prepared from the following raw materials, such as 5 to 60% of Tibet herba artemisiae, 4.5 to 60 % of bupleurum root, 10 to 88% of barbary wolfberry fruit, 1 to 80% of safflower and 0.5 to 25% of radix glycyrrhiza, and the proportion is the weight percentage of dry matters; (2). the medicinal materials according to the formula can be prepared into capsules, tablets, oral medicinal liquid, etc. and other forms. The patent medicine of the present invention has obvious treating effects on viral hepatitis A, viral hepatitis B, viral hepatitis C, viral hepatitis D, viral hepatitis E, acute icteric hepatitis and chronic persistent hepatitis; the total effective rate of various kinds of viral hepatitis is 89%, the cure rate is 80.8%, and the effective rate of the chronic persistent hepatitis is above 90%. The prescription has the advantages of fair formula, wide source of medicinal materials and no toxic or side effect, and is the new medical breakthrough for treating the hepatitis.

Description

Compound Tibet capillary artemisia patent medicine

The invention belongs to Chinese medicine patent medicine technical field, particularly a kind of is the compound recipe patent medicine of principal agent with the ZANGYINCHEN.

ZANGYINCHEN is gentianaceae plant Swertia mussotii Franch. or Swertia franchetiana H.Smith, all herbal medicine after drying.The ZANGYINCHEN single medicinal material has certain curative effect on treatment hepatitis disease, be restricted but cross cool its curative effect because of the property of medicine.

The objective of the invention is based on the ZANGYINCHEN medical material, select other number flavor medicine again for use, match in suitable ratio, make compound Tibet capillary artemisia patent medicine, this patent medicine all has satisfied curative effect to all kinds of viral hepatitis, through clinical practice in 20 years, also not finding has any toxicity, side effect to human body, is the new breakthrough of treatment hepatitis medicament, and China is a country that the incidence of hepatitis rate is higher, after dropping into clinical treatment, it can produce better economic and social benefit.

The feature of the compound Tibet capillary artemisia patent medicine of this invention is: one, prescription: ZANGYINCHEN 5-60%, and Radix Bupleuri 4.5-60%, structure Fructus Lycii 10-88%, Flos Carthami 1-80%, Radix Glycyrrhizae 0.5-25%, aforementioned proportion is percent by weight of dry matter; Two, the medical material with above-mentioned prescription can be made into forms such as capsule, tablet, oral liquid.ZANGYINCHEN, Radix Bupleuri, Fructus Lycii, Flos Carthami, Radix Glycyrrhizae etc. are Chinese crude drug, all measure with dry matter weight during batching.Capsular preparation technology one: the mixing of preparing burden → pulverize → sieve → encapsulated → product.Capsular preparation technology two: batching → ethanol extracts ZANGYINCHEN → distilling under reduced pressure continuously and reclaims ethanol → ZANGYINCHEN extractum; All the other four Chinese medicines in the prescription → pulverize → sieve mixing → with ZANGYINCHEN extractum mixing → granulation → drying → encapsulated → product.Capsular first kind of preparation technology is simpler, and blending process just amount becomes powder with these pulverizing medicinal materials subsequently with the load weighted by a certain percentage process of each flavor medical material, removes the bulky grain thing after sieving, and the fine powder mixing is encapsulated again, get final product product.Capsular second kind of preparation technology is complicated, and it is finished by two cover technologies.The blending process of first cover is still the load weighted by a certain percentage process of each flavor medical material, it is to be solvent with ethanol that ethanol extracts the ZANGYINCHEN operation continuously, the process of in extracting still, the effective ingredient lixiviate of ZANGYINCHEN being come out, distilling under reduced pressure recovery ethanol operation is the method by distilling under reduced pressure, reclaim alcoholic acid process in the extracting solution, the ZANGYINCHEN active ingredient in the extracting solution then becomes ZANGYINCHEN extractum.The second cover technology is with all the other four Chinese medicines in the prescription, be four medicines such as Radix Bupleuri, Fructus Lycii, Flos Carthami, Radix Glycyrrhizae, through being ground into powder, after screening out the bulky grain thing, mix homogeneously, four flavor powder medicines behind mixing again with ZANGYINCHEN extractum mixing, make shot-like particle, drying is removed moisture content, reinstall capsule product.The preparation technology of tablet: batching → ethanol extracts ZANGYINCHEN → distilling under reduced pressure continuously and reclaims ethanol → ZANGYINCHEN extractum; All the other four Chinese medicines in the prescription → pulverize → sieve mixing → with ZANGYINCHEN extractum mixing → granulation → drying → product.The preparation technology of tablet is basic identical with capsular preparation technology two, only lacks encapsulated operation, no longer describes in detail here.The preparation technology of oral liquid: mixing → add water temperature soaks → decocts batching → and filter and remove residue → filtrate concentrate → adds correctives → bottling sterilization → product.Batching mixing operation is the process that five kinds of medical materials is prepared by a certain percentage again mixing, add an amount of warm water soaking subsequently, decocting is exactly the process that decocts with warm fire, after treating that active ingredient has been endured in the soup, then remove residue with filtering method, filtrate is removed moisture content through concentrating again, improves liquor strength, add correctives again so that the effective good palatability of oral liquid, correctives has saccharide, food flavoring agent etc.After the bottling sterilization, just obtain the oral liquid product.

The dose of being grown up everyone every day is the medication amount of 200-300 gram behind five kinds of medical materials batching mixings, and the above-mentioned five kinds of medical materials that promptly should prepare the 200-300 gram are only adult's medication amount of everyone every day, and can cut down according to the circumstance or drink for child or state of an illness difference adds.Patent medicine of the present invention, to first type, B-mode, third type, hepatitis E, acute icterohepatitisshock, chronic persistent hepatitis all has significant curative effect, obviously is better than the medicine of existing treatment hepatitis, is 89% to the total effective rate of all kinds of viral hepatitis, its cure rate is 80.9%, the chronic persistent hepatitis effective percentage is reached more than 90%, and the patient's liver function of taking medicine enzyme index obviously reduces, and patient's subjective symptoms is eliminated or had clear improvement.This prescription prescription is reasonable, and crude drug source is extensive, does not have other toxicity, side effect again, and better economic and social benefit are arranged.

Accompanying drawing 1 is the technological process sketch drawing of compound Tibet capillary artemisia capsule drug.

Accompanying drawing 2 is the process flow diagram of compound Tibet capillary artemisia oral liquid patent medicine.

Embodiment one: ZANGYINCHEN 600 gram, Radix Bupleuri 80 grams, Fructus Lycii 100 grams, Flos Carthami 120 grams, Radix Glycyrrhizae 100 grams amount to 1000 grams, through pulverize, the mixing that sieves, encapsulated again capsule drug.

Embodiment two: ZANGYINCHEN 300 grams, and Radix Bupleuri 200 grams, Fructus Lycii 200 grams, Flos Carthami 150 grams, Radix Glycyrrhizae 150 grams amount to 1000 grams.Earlier 300 gram ZANGYINCHEN are extracted in ethanol continuously, treat that active ingredient has been extracted after, extracting solution distilling under reduced pressure recovery ethanol, extracting solution is made ZANGYINCHEN extractum.With other four Chinese medicine Radix Bupleuri, Fructus Lycii, Flos Carthami, Radix Glycyrrhizae pulverize separately, the mixing that sieves, behind its mixing fine powder again with ZANGYINCHEN extractum mix homogeneously, granulate, promptly make tablet, drying just can become tablet patent medicine.

Embodiment three: ZANGYINCHEN 100 grams, and Radix Bupleuri 400 grams, Fructus Lycii 100 grams, Flos Carthami, 200 grams, Radix Glycyrrhizae 200 grams amount to 1000 grams.With above-mentioned five kinds of medical material mix homogeneously, add water temperature and soak, decoct, through the elimination medicinal residues, the filtrate reconcentration removes part moisture content, adds correctives brown sugar, and the bottling high temperature sterilize promptly becomes the oral liquid product through after the assay was approved.

Claims

1. a compound Tibet capillary artemisia patent medicine is characterized in that it being to make capsule, tablet, oral liquid: ZANGYINCHEN 5-60% by following raw materials by weight percent, Radix Bupleuri 4.5-60%, Fructus Lycii 10-88%, Flos Carthami 1-80%, Radix Glycyrrhizae 0.5-25%.

2. compound Tibet capillary artemisia patent medicine according to claim 1 is characterized in that capsular preparation technology is: its raw material, pulverize, and the mixing that sieves, encapsulated, get product.

3. compound Tibet capillary artemisia patent medicine according to claim 1 is characterized in that capsular preparation technology is: its raw material, and ethanol continuous extraction ZANGYINCHEN, ethanol is reclaimed in distilling under reduced pressure, gets ZANGYINCHEN extractum; All the other four Chinese medicines are pulverized, and the mixing that sieves with ZANGYINCHEN extractum mixing, is granulated, and drying is encapsulated, gets product.

4. compound Tibet capillary artemisia patent medicine according to claim 1 is characterized in that the preparation technology of tablet is: its raw material, and ethanol continuous extraction ZANGYINCHEN, ethanol is reclaimed in distilling under reduced pressure, gets ZANGYINCHEN extractum; All the other four Chinese medicines are pulverized, and the mixing that sieves with ZANGYINCHEN extractum mixing, is granulated, and drying gets product.

5. compound Tibet capillary artemisia patent medicine according to claim 1 is characterized in that the preparation technology of oral liquid is: its raw material blending, and add water temperature and soak, decoct, filter and remove residue, filtrate concentrates, and adds correctives, and the bottling sterilization gets product.