CN108096371A - A kind of Oral Solutions of Zinc Gluconate and preparation method thereof - Google Patents
A kind of Oral Solutions of Zinc Gluconate and preparation method thereof Download PDFInfo
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- CN108096371A CN108096371A CN201810105893.4A CN201810105893A CN108096371A CN 108096371 A CN108096371 A CN 108096371A CN 201810105893 A CN201810105893 A CN 201810105893A CN 108096371 A CN108096371 A CN 108096371A
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- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 title claims abstract description 23
- 235000011478 zinc gluconate Nutrition 0.000 title claims abstract description 23
- 239000011670 zinc gluconate Substances 0.000 title claims abstract description 23
- 229960000306 zinc gluconate Drugs 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000003814 drug Substances 0.000 claims abstract description 49
- 235000018167 Reynoutria japonica Nutrition 0.000 claims abstract description 28
- 240000001341 Reynoutria japonica Species 0.000 claims abstract description 28
- 239000002994 raw material Substances 0.000 claims abstract description 27
- 244000197580 Poria cocos Species 0.000 claims abstract description 21
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 21
- 241000405414 Rehmannia Species 0.000 claims abstract description 20
- 229940079593 drug Drugs 0.000 claims abstract description 20
- 239000007788 liquid Substances 0.000 claims abstract description 17
- 235000008216 herbs Nutrition 0.000 claims abstract description 12
- 235000020374 simple syrup Nutrition 0.000 claims abstract description 10
- 235000013305 food Nutrition 0.000 claims abstract description 6
- 241000721047 Danaus plexippus Species 0.000 claims abstract description 4
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 19
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 19
- 238000002156 mixing Methods 0.000 claims description 9
- 239000006071 cream Substances 0.000 claims description 8
- 239000012528 membrane Substances 0.000 claims description 8
- 239000000919 ceramic Substances 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 6
- 239000011229 interlayer Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 244000068988 Glycine max Species 0.000 claims description 3
- 235000010469 Glycine max Nutrition 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000008213 purified water Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 238000000926 separation method Methods 0.000 claims description 2
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract description 16
- 229910052725 zinc Inorganic materials 0.000 abstract description 16
- 239000011701 zinc Substances 0.000 abstract description 16
- 230000009469 supplementation Effects 0.000 abstract description 12
- 230000036541 health Effects 0.000 abstract description 8
- 210000000952 spleen Anatomy 0.000 abstract description 8
- 210000001835 viscera Anatomy 0.000 abstract description 7
- 230000008901 benefit Effects 0.000 abstract description 6
- 239000008280 blood Substances 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 5
- 230000001079 digestive effect Effects 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract description 4
- 230000004069 differentiation Effects 0.000 abstract description 4
- 210000003734 kidney Anatomy 0.000 abstract description 4
- 206010039083 rhinitis Diseases 0.000 abstract description 4
- 208000011580 syndromic disease Diseases 0.000 abstract description 4
- 230000035622 drinking Effects 0.000 abstract description 2
- 230000010354 integration Effects 0.000 abstract description 2
- 239000003755 preservative agent Substances 0.000 abstract description 2
- 230000002335 preservative effect Effects 0.000 abstract description 2
- 230000001105 regulatory effect Effects 0.000 abstract description 2
- 238000003672 processing method Methods 0.000 abstract 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 239000011573 trace mineral Substances 0.000 description 6
- 235000013619 trace mineral Nutrition 0.000 description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
- 229960005069 calcium Drugs 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 229910052742 iron Inorganic materials 0.000 description 4
- 208000015817 Infant Nutrition disease Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000002720 Malnutrition Diseases 0.000 description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 description 2
- 240000006365 Vitis vinifera Species 0.000 description 2
- 235000014787 Vitis vinifera Nutrition 0.000 description 2
- 206010048259 Zinc deficiency Diseases 0.000 description 2
- 208000007502 anemia Diseases 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 235000003891 ferrous sulphate Nutrition 0.000 description 2
- 239000011790 ferrous sulphate Substances 0.000 description 2
- 244000000053 intestinal parasite Species 0.000 description 2
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 2
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 2
- 239000002932 luster Substances 0.000 description 2
- 230000001071 malnutrition Effects 0.000 description 2
- 235000000824 malnutrition Nutrition 0.000 description 2
- 208000015380 nutritional deficiency disease Diseases 0.000 description 2
- 238000010025 steaming Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- NAOLWIGVYRIGTP-UHFFFAOYSA-N 1,3,5-trihydroxyanthracene-9,10-dione Chemical compound C1=CC(O)=C2C(=O)C3=CC(O)=CC(O)=C3C(=O)C2=C1 NAOLWIGVYRIGTP-UHFFFAOYSA-N 0.000 description 1
- 206010001497 Agitation Diseases 0.000 description 1
- 244000292697 Polygonum aviculare Species 0.000 description 1
- 235000006386 Polygonum aviculare Nutrition 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- NEEHYRZPVYRGPP-IYEMJOQQSA-L calcium gluconate Chemical compound [Ca+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O NEEHYRZPVYRGPP-IYEMJOQQSA-L 0.000 description 1
- 229960004494 calcium gluconate Drugs 0.000 description 1
- 235000013927 calcium gluconate Nutrition 0.000 description 1
- 239000004227 calcium gluconate Substances 0.000 description 1
- 229940042228 calcium gluconate oral solution Drugs 0.000 description 1
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000009295 crossflow filtration Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229940100688 oral solution Drugs 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a kind of Oral Solutions of Zinc Gluconate and preparation method thereof, are related to traditional Chinese medicine health care product technical field.The prescription raw material of oral liquid of the present invention includes being good for the Radix Glycyrrhizae of the dual-purpose radix pseudostellariae of medicine, prepared rhizome of rehmannia, prepared fleece flower root, Rhizoma Atractylodis Macrocephalae and food and medicament dual-purpose, Poria cocos, dried orange peel；For the prescription using radix pseudostellariae as monarch drug in a prescription, prepared fleece flower root is ministerial drug, and Rhizoma Atractylodis Macrocephalae, Poria cocos, dried orange peel, prepared rhizome of rehmannia are to make medicine, the above all medicines of Radix Glycyrrhizae reconciliation, and preparation method includes crushing, decoction, simple syrup making and oral liquid and prepares four steps.The processing method of the present invention can simultaneously abundant effective component extracting in time, and while avoiding active ingredient long decoct and destroy；Homologous and integration of drinking and medicinal herbs Chinese medicine is good for medicine to form, do not add preservative, with traditional Chinese medical science organic conception, Coryza Treated by Syndrome Differentiation is principle, has the spleen kidney people having the same aspiration and interest, qi and blood and support the benefits of, fortune is helped by invigorating the spleen, strengthens digestive function, viscera function is adjusted, not zinc supplementation and play the role of zinc supplementation naturally --- natural zinc supplementation, integrally-regulated viscera function.
Description
Technical field
The present invention relates to traditional Chinese medicine health care product and preparation method thereof technical field, more particularly to a kind of Oral Solutions of Zinc Gluconate and its system
Preparation Method.
Background technology
Zinc supplementation currently on the market such as mends iron, replenishes the calcium at the dazzling health product, be all by external addition zinc, iron,
The member such as calcium usually supplements the trace element that human body lacks, and such as adds Zinc Gluuconate Oral Solution, the zinc gluconate of grape saccharic acid zinc
Piece adds children's ferrous sulfate syrup of ferrous sulfate, adds calcium gluconate oral solution with effect, the calcium gluconate tablet of grape Calciofon
Deng.The shortage of trace element is " visceral dysfunction " for theory of traditional Chinese medical science, belongs to the scope of " imbalance of yin and yang ", and above phase
It closes product and only passes through external microelement-supplementing, it is impossible to be solved the problems, such as from root.The traditional Chinese medical science think all diseases of human body be all because
For " imbalance of yin and yang ", all therapeutic purposes are provided to " Yin Yang balancing ", and " negative and positive reconciliation " can tackle the problem at its root, people
Body could Chang Baojian health.Health products are complicated to the effect of body made of Chinese medicine, are not the benefits of simple trace element
Fill, be by adjusting body just with heresy, it is cloudy with sun, qi-blood-body fluid and channels and collaterals and the balance of internal organs and to adjust micro member
The metabolism of element, potency improve the utilization rate of trace element with activity, maintain the balance of various trace elements in vivo.Therefore, city
On field be badly in need of one kind using traditional Chinese medical science organic conception, Coryza Treated by Syndrome Differentiation as principle, have the spleen kidney people having the same aspiration and interest, qi and blood and support the benefits of, pass through invigorating the spleen
Help fortune, strengthen digestive function, viscera function is adjusted, not zinc supplementation and play the role of zinc supplementation naturally, promote child health into
Long health products.
The content of the invention
The present invention provides a kind of Oral Solutions of Zinc Gluconate and preparation method thereof, the beautiful jades such as zinc supplementation currently on the market is overcome, mends iron, replenishes the calcium
The health product that thinkling sound meets the eye on every side all is the trace element that human body shortage is usually supplemented by members such as external addition zinc, iron, calcium, it is impossible to from
The defects of being solved the problems, such as on root provides one kind with traditional Chinese medical science organic conception, and Coryza Treated by Syndrome Differentiation is principle, using with the spleen kidney people having the same aspiration and interest, gas
Blood and medicine the benefits of support is good for the Chinese medicine of homologous and integration of drinking and medicinal herbs as prescription, not zinc supplementation and play the role of zinc supplementation naturally, can also change
Kind children are particular about food, apocleisis, poor appetite, sleep easily wake up with a start that irritated, stool digestion is not thorough and malnutrition, anaemia, small at night
Phenomena such as youngster's infantile malnutrition due to digestive disturbances or intestinalparasites, from source（The cause of disease）It is upper to solve the problems, such as.
In order to reach above-mentioned purpose, the present invention uses following specific technical solution：A kind of Oral Solutions of Zinc Gluconate, it is described oral
The prescription raw material of liquid includes the Radix Glycyrrhizae of the dual-purpose radix pseudostellariae of strong medicine, prepared rhizome of rehmannia, prepared fleece flower root, Rhizoma Atractylodis Macrocephalae and food and medicament dual-purpose, Poria cocos, old
Skin；For the prescription using radix pseudostellariae as monarch drug in a prescription, prepared fleece flower root is ministerial drug, and Rhizoma Atractylodis Macrocephalae, Poria cocos, dried orange peel, prepared rhizome of rehmannia are to make medicine, Radix Glycyrrhizae tune
With above all medicines.
Preferably, the radix pseudostellariae in the formula is genunie medicinal materials Zherong radix pseudostellariae, and the prepared fleece flower root is version in 2015
《Pharmacopoeia of People's Republic of China》How is the system of " decoction of black soybean steams after mixing thoroughly " of defined in the preparation method " steaming method " of " prepared fleece flower root "
The tuber of multiflower knotweed.
Preferably, the prescription raw material of the oral liquid further includes maltose.
It is further preferred that by weight, the prescription raw material includes 80-100 parts of radix pseudostellariae, 50-70 parts of prepared rhizome of rehmannia,
80-100 parts of prepared fleece flower root, 70-90 parts of Rhizoma Atractylodis Macrocephalae, 20-40 parts of Radix Glycyrrhizae, 70-90 parts of Poria cocos, 40-60 parts of dried orange peel, 200 parts of maltose,
The radix pseudostellariae is identical with prepared fleece flower root dosage, and radix pseudostellariae is with 2.5-4 times that prepared fleece flower root dosage is Radix Glycyrrhizae, prepared rhizome of rehmannia dosage
1.75-3 times of Radix Glycyrrhizae, Rhizoma Atractylodis Macrocephalae and Poria cocos dosage are equal.
It is further preferred that by weight, the prescription raw material includes 80 parts of radix pseudostellariae, 50 parts of prepared rhizome of rehmannia, what head of system
80 parts of crow, 70 parts of Rhizoma Atractylodis Macrocephalae, 20 parts of Radix Glycyrrhizae, 70 parts of Poria cocos, 40 parts of dried orange peel, 200 parts of maltose.
It is further preferred that by weight, the prescription raw material includes 90 parts of radix pseudostellariae, 60 parts of prepared rhizome of rehmannia, what head of system
90 parts of crow, 80 parts of Rhizoma Atractylodis Macrocephalae, 30 parts of Radix Glycyrrhizae, 80 parts of Poria cocos, 50 parts of dried orange peel, 200 parts of maltose.
It is further preferred that by weight, the prescription raw material includes 100 parts of radix pseudostellariae, 70 parts of prepared rhizome of rehmannia, what head of system
100 parts of crow, 90 parts of Rhizoma Atractylodis Macrocephalae, 40 parts of Radix Glycyrrhizae, 90 parts of Poria cocos, 60 parts of dried orange peel, 200 parts of maltose.
Another technical solution of the present invention is to additionally provide the preparation method of above-mentioned Oral Solutions of Zinc Gluconate, including following step
Suddenly：
（1）It crushes：The raw material in addition to maltose in prescription is crushed by weight, the raw material loading of crushing is boiled medicine
Bag obtains drug containing bag for decocting medicinal herbs；
（2）It decocts：By step（1）The drug containing bag for decocting medicinal herbs of gained is fitted into special decoction pot, once completes to decoct, through inorganic ceramic
UF membrane filters, then puts in interlayer steam heat type medicine boiler and be condensed into clear cream；The special decoction pot can will be decocted to certain journey
The liquid of degree is automatically separated out, is conducive to active ingredient and is fully dissolved out, and avoids active ingredient destroyed because long-time decocts；
The once completion decoction is when liquid is automatically separated out, and decoction pot automatic watering is persistently completed active ingredient and carried
It takes；
（3）Simple syrup makes：To step（1）Simple syrup is made in the maltose mixing that parts by weight are added in the clear cream；
（4）It is prepared by oral liquid：To step（3）Add purified water in the simple syrup of gained, mixing to obtain the final product.
Preferably, step（1）It is described to crush as coarse powder.
Preferably, the step（2）It decocts design parameter to be set as, by step（1）The drug containing bag for decocting medicinal herbs of gained is packed into special
It in decoction pot processed, once completes to decoct, is automatically separated the time for the first time 40 minutes, second was automatically separated the time as 30 minutes, warp
Inorganic ceramic UF membrane filters, then puts in interlayer steam heat type medicine boiler, and within control pressure 0.09MPa, steam is adjusted after boiling
Pressure keeps slightly boiling within 0.05 MPa, until being condensed into clear cream.
Compared with prior art, the present invention has the advantages that following prominent and effect：（1）The present invention is good for homologous and medicine with medicine
Homologous Chinese medicine composition is eaten, does not add preservative, with traditional Chinese medical science organic conception, Coryza Treated by Syndrome Differentiation is principle, has the spleen kidney people having the same aspiration and interest, qi and blood
And the benefits of supporting, spleen is source of generating QI and blood, and the ground of micro- generation helps fortune by invigorating the spleen, strengthens digestive function, internal organs work(
Can it is adjusted, not zinc supplementation and play the role of zinc supplementation naturally --- natural zinc supplementation, integrally-regulated viscera function, by dirty to itself
The conditioning of internal organs, starts with from the cause of disease, tackles the problem at its root, and plays the role of effecting a permanent cure；（2）Using spy in preparation process of the present invention
Decoction pot processed, in decoction process can simultaneously abundant effective component extracting in time, high temperature does not destroy having in medicinal material thus during president
Imitate ingredient；（3）The present invention is filtered using inorganic ceramic UF membrane, is based on the sieve effect of porous ceramic medium and the object that carries out
Matter isolation technics, using with the completely different dynamic of filter types " cross-flow filtration " side such as traditional " dead-end filtration " " cake filtration "
Formula：I.e. under pressure-driven, material liquid on the inside of membrane tube film surface with certain flow velocity flow at high speed, small-molecule substance（Liquid
Body）Along direction normal thereto through microporous barrier, macromolecular substances（Or solid particle）It is rejected by, fluid is made to reach separation concentration
With the purpose of purifying, have high temperature resistant, chemical stability good, energy is acidproof, alkaline-resisting, organic solvent-resistant, high mechanical strength, can be reversed
Flushing, anti-microbe ability is strong, clanability is strong, pore-size distribution is narrow, and infiltration capacity is big, and membrane flux is high, separating property is good and uses
The features such as long lifespan.
Specific embodiment
Following Examples further illustrate the present invention, but should not be taken as the limitation of the present invention：
Embodiment 1：A kind of Oral Solutions of Zinc Gluconate, the prescription raw material of the oral liquid include the dual-purpose radix pseudostellariae of strong medicine, prepared rhizome of rehmannia, system
The fleece-flower root, the Radix Glycyrrhizae of Rhizoma Atractylodis Macrocephalae and food and medicament dual-purpose, Poria cocos, dried orange peel；For the prescription using radix pseudostellariae as monarch drug in a prescription, prepared fleece flower root is minister
Medicine, Rhizoma Atractylodis Macrocephalae, Poria cocos, dried orange peel, prepared rhizome of rehmannia are to make medicine, the above all medicines of Radix Glycyrrhizae reconciliation；Radix pseudostellariae in the formula is genunie medicinal materials
Zherong radix pseudostellariae, the prepared fleece flower root are version in 2015《Pharmacopoeia of People's Republic of China》The preparation method " steaming method " of " prepared fleece flower root "
The prepared fleece flower root of " decoction of black soybean steams after mixing thoroughly " of middle defined；The prescription raw material of the oral liquid further includes maltose.
The prescription raw material includes：
Radix pseudostellariae 80g Rhizoma Atractylodis Macrocephalae 70g Poria cocos 70g dried orange peels 40g
Prepared rhizome of rehmannia 50g prepared fleece flower root 80g Radix Glycyrrhizae 20g maltose 200g
Above-mentioned prescription raw material is prepared according to the following steps：
（1）It crushes：The raw material in addition to maltose in prescription is crushed by weight, the raw material of crushing is packed into bag for decocting medicinal herbs
Drug containing bag for decocting medicinal herbs is obtained, it is described to crush as coarse powder；
（2）It decocts：By step（1）The drug containing bag for decocting medicinal herbs of gained is fitted into special decoction pot, once completes to decoct, and once completes to decoct
It boils, is automatically separated the time for the first time 40 minutes, second was automatically separated the time as 30 minutes, was filtered through inorganic ceramic UF membrane, then
It puts in interlayer steam heat type medicine boiler, steam pressure is adjusted within control pressure 0.09MPa, after boiling within 0.05 MPa, is protected
Slightly boiling is held, until being condensed into clear cream；
（3）Simple syrup makes：To step（1）Simple syrup is made in the maltose mixing that 200g is added in the clear cream；
（4）It is prepared by oral liquid：To step（3）In the simple syrup of gained plus purified water is to 1000mL, and mixing to obtain the final product.
Embodiment 2：A kind of Oral Solutions of Zinc Gluconate, the prescription raw material and preparation method of the oral liquid are same as Example 1,
The difference is that the weight of prescription raw material is：
Radix pseudostellariae 90g Rhizoma Atractylodis Macrocephalae 80g Poria cocos 80g dried orange peels 50g
Prepared rhizome of rehmannia 60g prepared fleece flower root 90g Radix Glycyrrhizae 30g maltose 200g
Embodiment 3：A kind of Oral Solutions of Zinc Gluconate, the prescription raw material and preparation method of the oral liquid are same as Example 1, difference
The weight being in prescription raw material is：
Radix pseudostellariae 100g Rhizoma Atractylodis Macrocephalae 90g Poria cocos 90g dried orange peels 60g
Prepared rhizome of rehmannia 70g prepared fleece flower root 100g Radix Glycyrrhizae 40g maltose 200g
Embodiment 4：Comparison of experiment results of the Oral Solutions of Zinc Gluconate in terms of smell, color and luster and pH value made of different embodiments, together
When choose 45 it is daily there is infantile malnutrition due to digestive disturbances or intestinalparasites and zinc-deficiency, sleep at night is easily waken up with a start, the children of the symptoms such as agitation are divided into 3 groups, often
15 people of group are taken orally the Oral Solutions of Zinc Gluconate in different embodiments, were scheduled to last with 3 months, compare its symptom improvement daily.
From the application of the various formula dosages of above embodiment：Dose is different, and certain variation also occurs for color and luster, pH value,
Different embodiments can receive significant effect, can promote children's healthy growth, can be used for treatment infantile malnutrition and zinc-deficiency
Children are particular about food, apocleisis, poor appetite, and sleep at night easily wakes up with a start, is irritated, and stool digestion is not thorough；On malnutrition, anaemia etc. are shown in
State patient.
The above description is merely a specific embodiment, but protection scope of the present invention is not limited thereto, any
Those skilled in the art disclosed herein technical scope in, can without the variation that creative work is expected or
It replaces, should be covered by the protection scope of the present invention.
Claims (10)
1. a kind of Oral Solutions of Zinc Gluconate, it is characterised in that the prescription raw material of the oral liquid includes the dual-purpose radix pseudostellariae of strong medicine, cultivated land
Huang, prepared fleece flower root, the Radix Glycyrrhizae of Rhizoma Atractylodis Macrocephalae and food and medicament dual-purpose, Poria cocos, dried orange peel；The prescription is using radix pseudostellariae as monarch drug in a prescription, prepared fleece flower root
For ministerial drug, Rhizoma Atractylodis Macrocephalae, Poria cocos, dried orange peel, prepared rhizome of rehmannia are to make medicine, the above all medicines of Radix Glycyrrhizae reconciliation.
2. a kind of Oral Solutions of Zinc Gluconate according to claim 1, it is characterised in that the radix pseudostellariae in the formula is genuine medicine
Material Zherong radix pseudostellariae, the prepared fleece flower root are version in 2015《Pharmacopoeia of People's Republic of China》The preparation method of " prepared fleece flower root " " is steamed
The prepared fleece flower root of " decoction of black soybean steams after mixing thoroughly " of defined in method ".
3. a kind of Oral Solutions of Zinc Gluconate according to claim 1, it is characterised in that the prescription raw material of the oral liquid further includes
Maltose.
4. a kind of Oral Solutions of Zinc Gluconate according to claim 3, it is characterised in that by weight, the prescription raw material includes
80-100 parts of radix pseudostellariae, 50-70 parts of prepared rhizome of rehmannia, 80-100 parts of prepared fleece flower root, 70-90 parts of Rhizoma Atractylodis Macrocephalae, 20-40 parts of Radix Glycyrrhizae, Poria cocos 70-
90 parts, 40-60 parts of dried orange peel, 200 parts of maltose, the radix pseudostellariae is identical with prepared fleece flower root dosage, and radix pseudostellariae is used with prepared fleece flower root
It measures as 2.5-4 times of Radix Glycyrrhizae, prepared rhizome of rehmannia dosage is 1.75-3 times of Radix Glycyrrhizae, and Rhizoma Atractylodis Macrocephalae and Poria cocos dosage are equal.
5. a kind of Oral Solutions of Zinc Gluconate according to claim 4, it is characterised in that by weight, the prescription raw material includes
80 parts of radix pseudostellariae, 50 parts of prepared rhizome of rehmannia, 80 parts of prepared fleece flower root, 70 parts of Rhizoma Atractylodis Macrocephalae, 20 parts of Radix Glycyrrhizae, 70 parts of Poria cocos, 40 parts of dried orange peel, maltose
200 parts.
6. a kind of Oral Solutions of Zinc Gluconate according to claim 4, it is characterised in that by weight, the prescription raw material includes
90 parts of radix pseudostellariae, 60 parts of prepared rhizome of rehmannia, 90 parts of prepared fleece flower root, 80 parts of Rhizoma Atractylodis Macrocephalae, 30 parts of Radix Glycyrrhizae, 80 parts of Poria cocos, 50 parts of dried orange peel, maltose
200 parts.
7. a kind of Oral Solutions of Zinc Gluconate according to claim 4, it is characterised in that by weight, the prescription raw material includes
100 parts of radix pseudostellariae, 70 parts of prepared rhizome of rehmannia, 100 parts of prepared fleece flower root, 90 parts of Rhizoma Atractylodis Macrocephalae, 40 parts of Radix Glycyrrhizae, 90 parts of Poria cocos, 60 parts of dried orange peel, malt
200 parts of sugar.
8. according to a kind of preparation method of any Oral Solutions of Zinc Gluconate of claim 1-7, it is characterised in that including following step
Suddenly：
It crushes：The raw material in addition to maltose in prescription is crushed by weight, the raw material of crushing is packed into bag for decocting medicinal herbs
Obtain drug containing bag for decocting medicinal herbs；
It decocts：By step（1）The drug containing bag for decocting medicinal herbs of gained is fitted into special decoction pot, once completes to decoct, through inorganic ceramic membrane
Separation filtration, then put in interlayer steam heat type medicine boiler and be condensed into clear cream；
Simple syrup makes：To step（1）Simple syrup is made in the maltose mixing that parts by weight are added in the clear cream；
It is prepared by oral liquid：To step（3）Add purified water in the simple syrup of gained, mixing to obtain the final product.
A kind of 9. preparation method of Oral Solutions of Zinc Gluconate according to claim 8, it is characterised in that step（1）The crushing is
Coarse powder.
A kind of 10. preparation method of Oral Solutions of Zinc Gluconate according to claim 8, it is characterised in that the step（2）It decocts
Design parameter is set as, by step（1）The drug containing bag for decocting medicinal herbs of gained is fitted into special decoction pot, once completes to decoct, for the first time
It is automatically separated the time 40 minutes, second was automatically separated the time as 30 minutes, was filtered through inorganic ceramic UF membrane, then put interlayer vapour heat
In formula medicine boiler, steam pressure is adjusted within control pressure 0.09MPa, after boiling within 0.05 MPa, keeps slightly boiling, until
It is condensed into clear cream.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110917131A (en) * | 2019-12-19 | 2020-03-27 | 福建天人药业股份有限公司 | Zinc-supplementing oral liquid and preparation method thereof |
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2018
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110917131A (en) * | 2019-12-19 | 2020-03-27 | 福建天人药业股份有限公司 | Zinc-supplementing oral liquid and preparation method thereof |
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