CN110917131A - Zinc-supplementing oral liquid and preparation method thereof - Google Patents
Zinc-supplementing oral liquid and preparation method thereof Download PDFInfo
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- 239000007788 liquid Substances 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 239000003814 drug Substances 0.000 claims abstract description 52
- 239000002994 raw material Substances 0.000 claims abstract description 27
- 235000018167 Reynoutria japonica Nutrition 0.000 claims abstract description 22
- 240000001341 Reynoutria japonica Species 0.000 claims abstract description 22
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 20
- 241000405414 Rehmannia Species 0.000 claims abstract description 18
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 17
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 16
- 244000197580 Poria cocos Species 0.000 claims abstract description 16
- 241000132012 Atractylodes Species 0.000 claims abstract description 14
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 14
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- 230000036541 health Effects 0.000 claims abstract description 8
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- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 25
- 229910052725 zinc Inorganic materials 0.000 claims description 25
- 239000011701 zinc Substances 0.000 claims description 25
- 230000001502 supplementing effect Effects 0.000 claims description 23
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 20
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 20
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- 235000020357 syrup Nutrition 0.000 claims description 4
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- 241001107116 Castanospermum australe Species 0.000 claims description 3
- 244000097654 Cudrania tricuspidata Species 0.000 claims description 3
- 235000010918 Cudrania tricuspidata Nutrition 0.000 claims description 3
- 241000721047 Danaus plexippus Species 0.000 claims description 3
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- 229940010454 licorice Drugs 0.000 claims 3
- 230000009977 dual effect Effects 0.000 claims 2
- 235000001188 Peltandra virginica Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 10
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- 210000004369 blood Anatomy 0.000 abstract description 6
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- 239000011573 trace mineral Substances 0.000 description 9
- 235000013619 trace mineral Nutrition 0.000 description 9
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 8
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
- 229960005069 calcium Drugs 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
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- 239000000126 substance Substances 0.000 description 4
- 206010013954 Dysphoria Diseases 0.000 description 3
- 235000017443 Hedysarum boreale Nutrition 0.000 description 3
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 3
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 description 3
- 239000004227 calcium gluconate Substances 0.000 description 3
- 229960004494 calcium gluconate Drugs 0.000 description 3
- 235000013927 calcium gluconate Nutrition 0.000 description 3
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 3
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 239000011670 zinc gluconate Substances 0.000 description 3
- 229960000306 zinc gluconate Drugs 0.000 description 3
- 235000011478 zinc gluconate Nutrition 0.000 description 3
- 208000015817 Infant Nutrition disease Diseases 0.000 description 2
- 208000002720 Malnutrition Diseases 0.000 description 2
- 206010048259 Zinc deficiency Diseases 0.000 description 2
- 208000007502 anemia Diseases 0.000 description 2
- 208000022531 anorexia Diseases 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 230000001079 digestive effect Effects 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 239000011790 ferrous sulphate Substances 0.000 description 2
- 235000003891 ferrous sulphate Nutrition 0.000 description 2
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 2
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 2
- 230000001071 malnutrition Effects 0.000 description 2
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- 208000015380 nutritional deficiency disease Diseases 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
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- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
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- 238000006467 substitution reaction Methods 0.000 description 1
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a zinc-supplementing oral liquid and a preparation method thereof, and relates to the technical field of traditional Chinese medicine health products. The formula raw materials of the oral liquid comprise radix pseudostellariae for both health and medicine, prepared rehmannia root, prepared fleece-flower root, bighead atractylodes rhizome, liquorice for both food and medicine, poria cocos and dried orange peel; the preparation method comprises the four steps of crushing, decocting, preparing simple syrup and preparing oral liquid. The processing method can timely and fully extract the effective components and avoid the damage of the effective components caused by long-term decoction; the traditional Chinese medicine composition is prepared from traditional Chinese medicines with medicinal and edible homology, does not contain preservatives, takes the holistic concept of traditional Chinese medicine and the principle of dialectical treatment, has the effects of regulating spleen and kidney and nourishing qi and blood, strengthens the digestion function by strengthening spleen and assisting transportation, regulates the functions of viscera, naturally plays the role of zinc supplement without zinc supplement, namely natural zinc supplement, and integrally regulates the functions of viscera.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine health products and preparation methods thereof, in particular to a zinc supplementing oral liquid and a preparation method thereof.
Background
At present, zinc, iron, calcium and other mineral filled health care products in the market supplement trace elements which are deficient in human bodies by externally adding zinc, iron, calcium and other elements, such as zinc gluconate oral liquid and zinc gluconate tablets added with zinc gluconate, children ferrous sulfate syrup added with ferrous sulfate, calcium gluconate oral liquid and calcium gluconate tablets added with calcium gluconate and the like. The lack of trace elements is the viscera dysfunction from the theory of traditional Chinese medicine, which belongs to the category of yin-yang dysfunction, and the related products can not solve the problems from the root only by externally supplementing the trace elements. The traditional Chinese medicine considers that all diseases of the human body are caused by yin-yang disharmony, all treatment purposes are to balance yin and yang, and the problem can be solved fundamentally by yin-yang harmony, so that the human body can keep healthy. The health product prepared from traditional Chinese medicines has complex effect on the body, is not simple in supplementing of trace elements, and improves the utilization rate of the trace elements and maintains the balance of various trace elements in the body by adjusting the balance of vital qi and pathogenic factors, yin and yang, qi, blood and body fluids, meridians and viscera of the body and regulating the metabolism, titer and activity of the trace elements. Therefore, a health care product which takes the holistic concept and syndrome differentiation treatment of the traditional Chinese medicine as the principle, has the effects of regulating the spleen and the kidney and nourishing qi and blood, strengthens the digestive function by strengthening the spleen and assisting transportation, regulates the functions of viscera, naturally plays the role of supplementing zinc without supplementing zinc and promotes the healthy growth of children is urgently needed in the market.
Disclosure of Invention
The invention provides a zinc-supplementing oral liquid and a preparation method thereof, overcomes the defect that the zinc, iron, calcium and other elements in the current health-care product full of eyes can not be solved radically by supplementing trace elements lacking in human bodies through external addition of zinc, iron, calcium and other elements, and provides a zinc-supplementing oral liquid which takes the holistic concept of traditional Chinese medicine and the syndrome differentiation treatment as the principle, adopts the traditional Chinese medicines with the effects of synchronously regulating spleen and kidney and nourishing qi and blood as well as homology of medicine and food as the formula, can naturally play the role of supplementing zinc without supplementing zinc, can also improve the phenomena of food choosing, anorexia, poor appetite, easy fright and dysphoria during sleep at night, incomplete digestion, malnutrition, anemia, infantile malnutrition and the like, and solves the problem from the source (causes).
In order to achieve the purpose, the invention adopts the following specific technical scheme: an oral liquid for supplementing zinc is prepared from radix Pseudostellariae, radix rehmanniae Preparata, radix Polygoni Multiflori Preparata, Atractylodis rhizoma, and Glycyrrhrizae radix, Poria, and pericarpium Citri Tangerinae; the formula takes radix pseudostellariae as a monarch drug, radix polygoni multiflori preparata as a ministerial drug, rhizoma atractylodis macrocephalae, poria cocos, pericarpium citri reticulatae and prepared rehmannia root as conductant drugs, and liquorice harmonizes the above drugs.
Preferably, the radix pseudostellariae in the formula is Daodian medicinal material Cudrania tricuspidata radix pseudostellariae, and the prepared fleece-flower root is prepared by uniformly stirring and steaming black bean juice specified in a preparation method steaming method of prepared fleece-flower root in the 2015 edition of pharmacopoeia of the people's republic of China.
Preferably, the formula raw materials of the oral liquid also comprise maltose.
Preferably, the raw materials of the formula comprise, by weight, 80-100 parts of radix pseudostellariae, 50-70 parts of prepared rehmannia root, 80-100 parts of prepared fleece-flower root, 70-90 parts of bighead atractylodes rhizome, 20-40 parts of liquorice, 70-90 parts of poria cocos, 40-60 parts of dried orange peel and 200 parts of maltose, wherein the dosages of the radix pseudostellariae and the prepared fleece-flower root are the same, the dosage of the radix pseudostellariae and the prepared fleece-flower root is 2.5-4 times of the liquorice, the dosage of the prepared rehmannia root is 1.75-3 times of the liquorice, and the dosages of the rhizoma atractylodis macroc.
Further preferably, the raw materials of the formula comprise, by weight, 80 parts of radix pseudostellariae, 50 parts of prepared rehmannia root, 80 parts of prepared fleece-flower root, 70 parts of bighead atractylodes rhizome, 20 parts of liquorice, 70 parts of poria cocos, 40 parts of dried orange peel and 200 parts of maltose.
Further preferably, the raw materials of the formula comprise, by weight, 90 parts of radix pseudostellariae, 60 parts of prepared rehmannia root, 90 parts of prepared fleece-flower root, 80 parts of bighead atractylodes rhizome, 30 parts of liquorice, 80 parts of poria cocos, 50 parts of dried orange peel and 200 parts of maltose.
Further preferably, the raw materials of the formula comprise, by weight, 100 parts of radix pseudostellariae, 70 parts of prepared rehmannia root, 100 parts of prepared fleece-flower root, 90 parts of bighead atractylodes rhizome, 40 parts of liquorice, 90 parts of poria cocos, 60 parts of dried orange peel and 200 parts of maltose.
The invention also provides a preparation method of the zinc supplement oral liquid, which comprises the following steps:
(1) crushing: crushing the raw materials except maltose in the formula according to parts by weight, and filling the crushed raw materials into a decoction medicine bag to obtain a medicine-containing decoction medicine bag;
(2) decocting: putting the medicated decocting bag obtained in the step (1) into a special decocting pot, decocting once, separating and filtering by an inorganic ceramic membrane, and concentrating into fluid extract in an interlayer steam heating type decocting pot; the special decocting pot can automatically separate the liquid medicine decocted to a certain degree, is beneficial to fully dissolving out the effective components and avoids the effective components from being damaged due to long-time decoction; the one-time decoction is that when the medicine liquid is automatically separated, the decocting pot automatically adds water to continuously extract the effective components;
(3) preparing simple syrup: adding maltose in parts by weight into the clear paste in the step (1), and uniformly mixing to prepare simple syrup;
(4) preparing oral liquid: and (4) adding purified water into the simple syrup obtained in the step (3), and uniformly mixing to obtain the syrup.
Preferably, the pulverization in the step (1) is coarse powder.
Preferably, the specific decocting parameters in the step (2) are set, the medicine-containing decocting medicine bag obtained in the step (1) is placed into a special decocting pot, decocting is completed once, the first automatic separation time is 40 minutes, the second automatic separation time is 30 minutes, the medicine bag is separated and filtered through an inorganic ceramic membrane, then the medicine bag is placed into a steam-heating type medicine boiling pot with a sandwich layer, the pressure is controlled within 0.09MPa, the steam pressure is adjusted within 0.05 MPa after boiling, and micro-boiling is kept until the medicine bag is concentrated into clear paste.
Compared with the prior art, the invention has the following outstanding advantages and effects: (1) the traditional Chinese medicine composition is prepared from traditional Chinese medicines with homology of medicine and health and homology of medicine and food, does not add preservatives, takes the holistic concept of traditional Chinese medicine and the principle of dialectical treatment, has the effects of harmonizing spleen and kidney and nourishing qi and blood, takes the spleen as the source of qi and blood generation, generates trace elements, strengthens the digestive function by strengthening spleen and assisting transportation, regulates the functions of viscera, naturally plays the role of zinc supplement without zinc supplement-natural zinc supplement and integrally regulates the functions of viscera, starts from the etiology by conditioning the viscera per se, fundamentally solves the problems and plays the role of treating the root cause; (2) the special decocting pot is adopted in the preparation process, so that the effective components can be timely and fully extracted in the decocting process, and the effective components in the medicinal materials cannot be damaged due to high temperature for a long time; (3) the invention adopts inorganic ceramic membrane separation filtration, is a substance separation technology based on the sieving effect of a porous ceramic medium, and adopts a dynamic cross-flow filtration mode which is completely different from the traditional filtration modes such as 'dead-end filtration' and 'filter cake filtration': under the drive of pressure, the raw material liquid flows at a high speed on the surface of the inner film layer of the film tube at a certain flow speed, small molecular substances (liquid) penetrate through the microporous film along the direction vertical to the small molecular substances, and large molecular substances (or solid particles) are intercepted by the film, so that the fluid achieves the purposes of separation, concentration and purification.
Detailed Description
The following examples further illustrate the invention but should not be construed as limiting it:
example 1: an oral liquid for supplementing zinc is prepared from radix Pseudostellariae, radix rehmanniae Preparata, radix Polygoni Multiflori Preparata, Atractylodis rhizoma, and Glycyrrhrizae radix, Poria, and pericarpium Citri Tangerinae; the composition takes radix pseudostellariae as a monarch drug, radix polygoni multiflori preparata as a ministerial drug, rhizoma atractylodis macrocephalae, poria cocos, pericarpium citri reticulatae and prepared rehmannia root as a conductant drug, and liquorice harmonizes the above drugs; the radix pseudostellariae in the formula is genuine medicinal material Cudrania tricuspidata radix pseudostellariae, and the prepared fleece-flower root is prepared fleece-flower root which is prepared by uniformly stirring and steaming black bean juice specified in a preparation method steaming method of prepared fleece-flower root in the 2015 edition of pharmacopoeia of the people's republic of China; the formula raw materials of the oral liquid also comprise maltose.
The formula comprises the following raw materials:
radix pseudostellariae 80g, bighead atractylodes rhizome 70g, poria cocos 70g, dried orange peel 40g
Prepared rehmannia root 50g prepared fleece flower root 80g licorice root 20g maltose 200g
The formula raw materials are prepared according to the following steps:
(1) crushing: pulverizing raw materials except maltose in the formula according to weight, and filling the pulverized raw materials into a decoction medicine bag to obtain a medicine-containing decoction medicine bag, wherein the pulverized raw materials are coarse powder;
(2) decocting: putting the medicated decocting medicinal bag obtained in the step (1) into a special decocting pot, completing decocting once, automatically separating for 40 minutes for the first time, separating and filtering for 30 minutes by an inorganic ceramic membrane, putting into a steam-heating type medicine decocting pot with an interlayer, controlling the pressure within 0.09MPa, adjusting the steam pressure within 0.05 MPa after boiling, keeping slight boiling until concentrating into clear paste;
(3) preparing simple syrup: adding 200g of maltose into the clear paste in the step (1), and uniformly mixing to prepare simple syrup;
(4) preparing oral liquid: and (4) adding purified water to 1000mL of the simple syrup obtained in the step (3), and uniformly mixing to obtain the syrup.
Example 2: the zinc supplementing oral liquid has the same formula raw materials and preparation method as the oral liquid in the embodiment 1, and is characterized in that the formula raw materials comprise the following components in parts by weight:
radix pseudostellariae 90g, bighead atractylodes rhizome 80g, poria cocos 80g, dried orange peel 50g
Prepared rehmannia root 60g prepared fleece flower root 90g prepared licorice root 30g maltose 200g
Example 3: the zinc supplementing oral liquid has the same formula raw materials and preparation method as the oral liquid in the embodiment 1, and is characterized in that the formula raw materials comprise the following components in parts by weight:
radix pseudostellariae 100g, bighead atractylodes rhizome 90g, poria cocos 90g, dried orange peel 60g
Prepared rehmannia root 70g prepared fleece flower root 100g licorice root 40g maltose 200g
Example 4: the experimental results of the zinc supplementing oral liquid prepared in different embodiments on the aspects of smell, color and pH value are compared, and 45 children with symptoms of malnutritional stagnation and zinc deficiency in daily life and easy fright, dysphoria and the like during sleeping at night are selected and averagely divided into 3 groups, each group comprises 15 people, the zinc supplementing oral liquid in different embodiments is orally taken every day, and the symptom improvement effect is compared by taking 3 months as a period.
Application of the various formulation dosages from the above examples: different embodiments can achieve obvious effects on treating infantile malnutrition and zinc deficiency, can promote the healthy growth of children, and can be used for treating monophagia, anorexia, poor appetite of children, easy awakening and dysphoria in sleep at night, and incomplete digestion of excrement; malnutrition, anemia and the like with the above-mentioned symptoms.
The above description is only an embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be made by those skilled in the art without inventive work within the technical scope of the present invention are included in the scope of the present invention.
Claims (10)
1. An oral liquid for supplementing zinc is characterized in that the raw materials of the prescription of the oral liquid comprise radix pseudostellariae for health and medicine dual purpose, prepared rehmannia root, prepared fleece flower root, largehead atractylodes rhizome, liquorice for food and medicine dual purpose, tuckahoe and dried orange peel; the formula takes radix pseudostellariae as a monarch drug, radix polygoni multiflori preparata as a ministerial drug, rhizoma atractylodis macrocephalae, poria cocos, pericarpium citri reticulatae and prepared rehmannia root as conductant drugs, and liquorice harmonizes the above drugs.
2. The zinc supplementing oral liquid according to claim 1, wherein the radix pseudostellariae in the formula is genuine medicinal material Cudrania tricuspidata radix pseudostellariae, and the prepared radix polygoni multiflori is prepared by uniformly stirring and steaming black bean juice specified in a steaming method of a preparation method of prepared radix polygoni multiflori in 2015 edition pharmacopoeia of the people's republic of China.
3. The oral liquid for supplementing zinc according to claim 1, wherein the raw materials of the prescription of the oral liquid further comprise maltose.
4. The zinc supplementing oral liquid according to claim 3, wherein the raw materials of the formula comprise, by weight, 80-100 parts of radix pseudostellariae, 50-70 parts of prepared rehmannia root, 80-100 parts of prepared fleece-flower root, 70-90 parts of bighead atractylodes rhizome, 20-40 parts of licorice, 70-90 parts of poria cocos, 40-60 parts of dried orange peel and 200 parts of maltose, the amount of the radix pseudostellariae and the prepared fleece-flower root is the same, the amount of the radix pseudostellariae and the prepared fleece-flower root is 2.5-4 times of the licorice, the amount of the prepared rehmannia root is 1.75-3 times of the licorice, and the amount of the bighead atractylodes rhizome and the poria.
5. The zinc supplementing oral liquid according to claim 4, wherein the raw materials of the formula comprise, by weight, 80 parts of radix pseudostellariae, 50 parts of prepared rehmannia root, 80 parts of prepared fleece-flower root, 70 parts of bighead atractylodes rhizome, 20 parts of liquorice, 70 parts of poria cocos, 40 parts of dried orange peel and 200 parts of maltose.
6. The zinc supplementing oral liquid according to claim 4, wherein the raw materials of the formula comprise, by weight, 90 parts of radix pseudostellariae, 60 parts of prepared rehmannia root, 90 parts of prepared fleece-flower root, 80 parts of bighead atractylodes rhizome, 30 parts of liquorice, 80 parts of poria cocos, 50 parts of dried orange peel and 200 parts of maltose.
7. The zinc supplementing oral liquid according to claim 4, wherein the raw materials of the formula comprise, by weight, 100 parts of radix pseudostellariae, 70 parts of prepared rehmannia root, 100 parts of prepared fleece-flower root, 90 parts of bighead atractylodes rhizome, 40 parts of liquorice, 90 parts of poria cocos, 60 parts of dried orange peel and 200 parts of maltose.
8. The preparation method of the zinc supplementing oral liquid according to any one of claims 1 to 7, characterized by comprising the following steps:
crushing: crushing the raw materials except maltose in the formula according to parts by weight, and filling the crushed raw materials into a decoction medicine bag to obtain a medicine-containing decoction medicine bag;
decocting: putting the medicated decocting bag obtained in the step (1) into a special decocting pot, decocting once, separating and filtering by an inorganic ceramic membrane, and concentrating into fluid extract in an interlayer steam heating type decocting pot;
preparing simple syrup: adding maltose in parts by weight into the clear paste in the step (1), and uniformly mixing to prepare simple syrup;
preparing oral liquid: and (4) adding purified water into the simple syrup obtained in the step (3), and uniformly mixing to obtain the syrup.
9. The method for preparing zinc-supplementing oral liquid according to claim 8, wherein the pulverization of step (1) is coarse powder.
10. The preparation method of the zinc supplementing oral liquid according to claim 8, wherein the specific decocting parameters in the step (2) are set such that the medicine-containing decocting medicinal bag obtained in the step (1) is placed into a special decocting pot, decocting is completed once, the first automatic separation time is 40 minutes, the second automatic separation time is 30 minutes, the medicine-containing decocting medicinal bag is separated and filtered by an inorganic ceramic membrane, the medicine-containing decocting medicinal bag is placed into a steam-heating type medicine decocting pot with a sandwich layer, the pressure is controlled within 0.09MPa, the steam pressure is adjusted within 0.05 MPa after boiling, and micro-boiling is kept until the medicine-containing decocting medicinal bag is concentrated into clear paste.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115531437A (en) * | 2022-11-01 | 2022-12-30 | 广东好味鲜菜品与营养研究所 | Composition containing radix pseudostellariae and preparation method of granules of composition |
| CN115531436A (en) * | 2022-10-13 | 2022-12-30 | 广东好味鲜菜品与营养研究所 | A pharmaceutical composition granule containing radix Pseudostellariae, and its preparation method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108096371A (en) * | 2018-02-02 | 2018-06-01 | 福建天人药业股份有限公司 | A kind of Oral Solutions of Zinc Gluconate and preparation method thereof |
| CN110151814A (en) * | 2019-06-20 | 2019-08-23 | 福建天人药业股份有限公司 | A kind of concocting method of instant honey radix pseudostellariae |
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2019
- 2019-12-19 CN CN201911314530.2A patent/CN110917131A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108096371A (en) * | 2018-02-02 | 2018-06-01 | 福建天人药业股份有限公司 | A kind of Oral Solutions of Zinc Gluconate and preparation method thereof |
| CN110151814A (en) * | 2019-06-20 | 2019-08-23 | 福建天人药业股份有限公司 | A kind of concocting method of instant honey radix pseudostellariae |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115531436A (en) * | 2022-10-13 | 2022-12-30 | 广东好味鲜菜品与营养研究所 | A pharmaceutical composition granule containing radix Pseudostellariae, and its preparation method |
| CN115531437A (en) * | 2022-11-01 | 2022-12-30 | 广东好味鲜菜品与营养研究所 | Composition containing radix pseudostellariae and preparation method of granules of composition |
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Application publication date: 20200327 |