CN115531437A - Composition containing radix pseudostellariae and preparation method of granules of composition - Google Patents
Composition containing radix pseudostellariae and preparation method of granules of composition Download PDFInfo
- Publication number
- CN115531437A CN115531437A CN202211357623.5A CN202211357623A CN115531437A CN 115531437 A CN115531437 A CN 115531437A CN 202211357623 A CN202211357623 A CN 202211357623A CN 115531437 A CN115531437 A CN 115531437A
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- China
- Prior art keywords
- parts
- mixing
- polyethylene glycol
- sodium bicarbonate
- honey
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Classifications
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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Abstract
The invention provides a composition containing radix pseudostellariae and a preparation method of granules of the composition, and relates to the technical field of preparation of traditional Chinese medicine granules. The composition comprises the components of radix pseudostellariae, tuckahoe, rhizoma atractylodis macrocephalae, honey-fried licorice root, erythritol, dextrin, sorbitol, honey, citric acid, probiotic freeze-dried powder, polyethylene glycol and sodium bicarbonate; the medicinal material components are derived from medicinal and edible available raw materials, and the raw materials are reasonably compatible and have synergistic effect. The composition is applied to preparing products with the functions of nourishing yin, promoting the production of body fluid, tonifying qi, strengthening spleen and enhancing immunity, wherein the preparation method of the granules mainly comprises the following steps: soaking and boiling to obtain extract, respectively mixing with mixture of citric acid, sodium bicarbonate and polyethylene glycol to obtain acid and alkali soft materials, granulating, mixing, and making into granule. The granule has effects of invigorating spleen, invigorating qi, and enhancing immunity, and has good taste and smell.
Description
Technical Field
The invention belongs to the technical field of preparation of traditional Chinese medicine granules, and particularly relates to a composition containing radix pseudostellariae and a preparation method of granules of the composition.
Background
With the acceleration of the life rhythm and irregular work and rest of people, the burden of the spleen and the stomach of most people is increased, the immunity is reduced, and sub-health problems exist, so that people pay attention to the functions of strengthening the spleen and nourishing the stomach, tonifying qi and generating blood and improving the intestinal function of the spleen and the stomach. At present, the fast-paced life enables more and more people to select the medicinal and edible traditional Chinese medicine preparation with high instant property to improve the immunity. Moreover, with the extensive and intensive research on traditional Chinese medicine, preparations made from medicinal and edible traditional Chinese medicines as main raw materials are endless and popular with consumers.
However, the medicinal and edible preparation in the market has the problems of high sugar content, bitter taste in the mouth, difficult odor of the traditional Chinese medicine, undefined active ingredients, uncertain addition amount and adding mode, unobvious resistance improving effect, high price and the like. And the medicinal and edible beverage is inconvenient to carry and store, usually contains certain chemical additives, preservatives and the like, and has side effects after being eaten for a long time. Therefore, the research on the preparation of the granules which are healthy, nutritional and delicious and have simple storage conditions and convenient eating methods becomes a key point.
There are many reports about medicine-food homologous particles, and a Chinese patent invention 201810516927.9 discloses a preparation process of a traditional Chinese medicine granule and the traditional Chinese medicine granule prepared by the preparation process, wherein the preparation process of the traditional Chinese medicine granule comprises the following steps: the raw material medicines are decocted and extracted, extract is obtained after solid-liquid separation, extract powder is obtained after concentration and auxiliary materials are added, and then the traditional Chinese medicine granules are obtained through dry granulation. The high-speed separation and purification method and the dry granulation are combined for use, and the prepared traditional Chinese medicine granules have high content of effective components and less impurities; the production cost is low, the utilization rate of raw materials is high, and the production efficiency is high; solves the problems of bitter taste, complicated and time-consuming decoction process, inconvenient transportation and storage, and the like of the traditional Chinese medicine decoction. However, the method used in the patent is only suitable for pharmacy to use, ensures the curative effect, and has the problems of over-concentrated traditional Chinese medicine taste and poor mouthfeel for daily health care.
The Chinese invention patent CN202010420819.9 discloses a composite granule and a preparation method thereof, wherein the formula of the composite granule comprises the following main materials in parts by weight: 1-3 parts of ginseng, 1-3 parts of bighead atractylodes rhizome, 2-4 parts of poria cocos, 0.5-0.8 part of honey-fried licorice root, 1-3 parts of composite powder, 30-40 parts of royal jelly, 3-5 parts of wild pueraria, 1-2 parts of dandelion, 1-2 parts of schisandra chinensis, 0.5-0.8 part of astragalus membranaceus, 5-7 parts of composite sugar, 0.2-0.4 part of medlar, 2-3 parts of polygonum multiflorum, 2-3 parts of liquorice and 1-2 parts of dried ginger. The preparation method of the composite particles comprises the steps of material taking, material frying, grinding, premixing, starting a liquid spraying air pump to provide a material mixing medium, particle drying and the like. The invention adds a grinding procedure in the granulating process and increases the fineness of the granules. However, the compound sugar component of the invention is a mixture of sucrose and lactose, which is not favorable for controlling blood sugar, and the intake of excessive sugar can not only cause obesity and other conditions, but also is not suitable for the health maintenance requirements of chronic patients such as diabetes patients or ulcer patients. The traditional Chinese medicinal materials have special odor, and the taste is difficult to change when the traditional Chinese medicinal materials are decocted for drinking. When a plurality of medicines are used together, the taste and smell are more difficult to control.
In view of the above, the invention provides a preparation method of a composition containing radix pseudostellariae and granules thereof, which focuses on taste adjustment and flavor improvement, and adopts a wet granulation technology to decoct, concentrate and granulate prescription drugs to prepare safe, healthy granules which can be taken for a long time, have the effects of nourishing yin, promoting the production of body fluid, benefiting qi and improving immunity, have good flavor and taste of traditional Chinese medicines, and are portable.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a composition containing radix pseudostellariae and a preparation method of granules of the composition, wherein the radix pseudostellariae which is homologous in medicine and food is combined with tuckahoe, atractylodes macrocephala and honey-fried licorice root, and the mixture is decocted, concentrated and granulated to prepare the traditional Chinese medicine flavor granules which are safe, can be taken for a long time, have the effects of strengthening spleen and replenishing qi and improving immunity, and have good taste.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
first, the present invention provides a composition comprising the following components: radix pseudostellariae, poria cocos, bighead atractylodes rhizome, honey-fried licorice root, erythritol, dextrin, sorbitol, honey, citric acid, probiotic freeze-dried powder, polyethylene glycol (PEG) and sodium bicarbonate.
Preferably, the composition comprises the following components in parts by weight: 1-5 parts of radix pseudostellariae, 1-5 parts of poria cocos, 1-5 parts of bighead atractylodes rhizome, 1-4 parts of honey-fried licorice root, 10-20 parts of erythritol, 10-16 parts of dextrin, 2-4 parts of sorbitol, 2-4 parts of honey, 0.1-0.5 part of citric acid, 1-5 parts of probiotic freeze-dried powder, 1-4 parts of polyethylene glycol and 1-2 parts of sodium bicarbonate.
Further preferably, the composition comprises the following components in parts by weight: 3-4 parts of radix pseudostellariae, 2-4 parts of poria cocos, 2-4 parts of bighead atractylodes rhizome, 2-3 parts of honey-fried licorice root, 12-16 parts of erythritol, 12-15 parts of dextrin, 2-3 parts of sorbitol, 2-3 parts of honey, 0.1-0.3 part of citric acid, 1-4 parts of probiotic freeze-dried powder, 2-4 parts of polyethylene glycol and 1-1.5 parts of sodium bicarbonate.
Still further preferably, the composition comprises the following components in parts by weight: 4 parts of radix pseudostellariae, 3 parts of poria cocos, 3 parts of bighead atractylodes rhizome, 2 parts of honey-fried licorice root, 12 parts of erythritol, 15 parts of dextrin, 3 parts of sorbitol, 4 parts of honey, 0.2 part of citric acid, 3 parts of probiotic freeze-dried powder, 3 parts of polyethylene glycol and 1.5 parts of sodium bicarbonate.
Preferably, the dextrin is selected from at least one of resistant dextrin, white dextrin, yellow dextrin, corn dextrin, cyclodextrin and maltodextrin.
Further preferably, the dextrin is selected from at least one of corn dextrin and white dextrin.
Preferably, the probiotic freeze-dried powder comprises the following components: bifidobacterium infantis lyophilized powder, bifidobacterium lactis lyophilized powder, bifidobacterium adolescentis lyophilized powder, lactobacillus rhamnosus lyophilized powder, lactobacillus casei lyophilized powder, lactobacillus acidophilus lyophilized powder, bifidobacterium longum lyophilized powder, lactobacillus reuteri lyophilized powder and Bifidobacterium animalis lyophilized powder.
Preferably, the polyethylene glycol is selected from at least one of PEG-400, PEG-600, PEG-1000, PEG-1500, PEG-4000, PEG-6000 and PEG-8000.
Further preferably, the polyethylene glycol is selected from at least one of PEG-1000, PEG-6000 and PEG-8000.
Still more preferably, the polyethylene glycol is PEG-6000, and in the present application, the polyethylene glycol functions as a wrapping material for wrapping sodium bicarbonate, so as to achieve a sustained release effect.
Moreover, the invention also provides application of the composition in preparing products with the functions of nourishing yin, promoting the production of body fluid, tonifying qi, strengthening spleen and enhancing immunity.
Meanwhile, the invention also provides a product with the functions of nourishing yin, promoting the production of body fluid, tonifying qi, strengthening spleen and enhancing immunity, which comprises the composition.
Preferably, the product is in the form of granules, powder, tablets, drinks, effervescent agents or pills.
Finally, the invention provides a process for the preparation of a granular product comprising the above composition, comprising the steps of:
(1) Soaking radix Pseudostellariae, poria, atractylodis rhizoma, and radix Glycyrrhizae Preparata in water, boiling, and filtering to obtain filtrate 1 and residue;
(2) Adding water into the filter residue obtained in the step (1) continuously, boiling, and filtering to obtain a filtrate 2;
(3) Mixing the filtrate 1 and the filtrate 2 to obtain a total filtrate;
(4) Concentrating the total filtrate obtained in the step (3), and continuously concentrating the supernatant to obtain an extract;
(5) Mixing the extract with Mel and sorbitol, adding erythritol and dextrin to obtain dry extract;
(6) Dividing the dry extract into two parts, mixing one part with citric acid, and mixing with ethanol to obtain soft acidic material; mixing the other part with mixture of sodium bicarbonate and polyethylene glycol, and mixing with ethanol to obtain soft alkaline material;
(7) Sieving the acid soft material and the alkali soft material respectively, granulating, oven drying, and mixing to obtain composition granule.
Preferably, in the step (1), the soaking in water is carried out for 20-90min, wherein the weight ratio of the radix pseudostellariae, the poria cocos, the bighead atractylodes rhizome, the honey-fried licorice root and the water is 1.
Preferably, in step (1), the boiling is: boiling with strong fire, boiling with slow fire for 0.5-2 hr, and filtering while hot.
Preferably, in the step (2), the water is added for boiling, specifically: adding water with the same weight as that in the step (1), boiling with strong fire, then slightly boiling with soft fire for 0.5-1h, and filtering while hot.
Preferably, in the step (4), the concentration is reduced pressure concentration, when the wall is not hung, the centrifugation is carried out at 0-10 ℃,6000-10000r/min and 5-15min, and the supernatant is taken and continuously concentrated by using an evaporating dish to obtain the extract.
Preferably, in the step (4), the medicine content of the extract is 0.5-3g/mL.
Further preferably, the medicine content of the extract is 1-2g/mL.
Preferably, in the step (5), the erythritol and the dextrin are dried at a low temperature and then screened for use.
Preferably, in the step (5), the mass ratio of the extract to the dextrin to the erythritol is 1.
Further preferably, the mass ratio of the extract to the dextrin to the erythritol is 1-3.
Preferably, in the step (6), the soft acid material is prepared by: mixing the dry extract and citric acid uniformly by equivalent incremental method, and mixing with anhydrous alcohol to obtain soft acid material; the preparation of the alkali soft material is specifically as follows: mixing the dry extract with a mixture of sodium bicarbonate and polyethylene glycol, and mixing with anhydrous ethanol to obtain an alkali soft material; the acid soft material and the alkali soft material are prepared by being held into a ball by hand and being scattered by light pressing.
Preferably, in the step (6), the mixture of sodium bicarbonate and polyethylene glycol refers to sodium bicarbonate coated by polyethylene glycol: heating polyethylene glycol at 60-80 deg.C to molten state, mixing with sodium bicarbonate, pulverizing, and sieving; the mass ratio of the polyethylene glycol to the sodium bicarbonate is 1-3.
Preferably, in step (7), the sieving is performed by using a No. 1 sieve and a No. 5 sieve, and the total amount of the sieve with the particle size larger than the No. 1 sieve and the sieve with the particle size smaller than the No. 5 sieve is not more than 15%.
Preferably, in the step (7), the drying specifically comprises placing the sieved particles into a preheated oven, and drying at 30-50 ℃ for 60-120min, wherein the moisture content is controlled to be lower than 2% every 30min of turnover.
Preferably, in the step (7), the mixing is to mix the dried particles prepared from the acid soft material and the alkali soft material uniformly according to a mass ratio of 1.
Compared with the prior art, the invention has the following beneficial effects:
(1) According to the invention, the raw materials of radix pseudostellariae, poria cocos, bighead atractylodes rhizome and honey-fried licorice root which are homologous in medicine and food are reasonably compatible, and the probiotic freeze-dried powder is added, so that the absorption of the medicine is improved, and the synergistic effect of nourishing yin, promoting the production of body fluid, tonifying spleen, benefiting qi and enhancing immunity is achieved.
(2) The product adopts a novel technology and a preparation process for precipitating the water decoction, and the traditional Chinese medicine water decoction has the advantages of low toxicity, no preservative, health care and health preservation; the preparation process of the invention improves the problem of low stability and effectively removes the defects of poor mouthfeel and unpleasant taste.
(3) The product selects a relatively healthy sweetening agent erythritol on the basis of a traditional Chinese medicine compound, is different from the traditional granules, does not participate in sugar metabolism and blood sugar change, is suitable for diabetics to eat, does not ferment in colon, can avoid stomach discomfort, does not easily cause oral cavity problems, and meets the dual requirements of paying attention to health preservation and taste.
(4) The composition granules have lower requirement on the storage condition, are convenient to carry, and can be drunk after being brewed at any time.
Detailed Description
The following non-limiting examples are presented to enable those of ordinary skill in the art to more fully understand the present invention and are not intended to limit the invention in any way. The following is merely an exemplary illustration of the scope of the claims of the present application and various changes and modifications of the invention of the present application may be made by those skilled in the art based on the disclosure, which should also fall within the scope of the claims of the present application.
The present invention will be further described below by way of specific examples. The various chemicals used in the examples of the present invention were obtained by conventional commercial routes unless otherwise specified.
In the present application, the components in the composition:
radix pseudostellariae: has effects in invigorating qi, nourishing blood, promoting salivation, and invigorating spleen and stomach. Tonics, tonics for deficiency and qi. The efficacy is mainly as follows: tonify the spleen and lung, replenish qi and promote the production of body fluid, and treat cough due to lung deficiency, spleen deficiency, anorexia and mental fatigue. Has mild drug property and sweet taste, and has the functions of tonifying qi and promoting the production of body fluid. Modern pharmacological experimental research proves that the radix pseudostellariae contains cyclic peptides, triterpenoid saponins and polysaccharide substances, and has the effects of enhancing immunity, prolonging life, resisting fatigue, stress, cough, bacteria and virus and the like.
Tuckahoe, poria cocos: poria cocos is mild in nature, tonifies without being drastic, benefits without being fierce, and can eliminate pathogens and strengthen body resistance. The Poria has effects of eliminating dampness, promoting diuresis, invigorating spleen, regulating stomach function, calming heart, and tranquilizing mind.
White atractylodes rhizome: it enters spleen and stomach meridians, and has effects of invigorating spleen, invigorating qi, eliminating dampness, promoting diuresis, arresting sweating, and preventing miscarriage. Mainly treats spleen qi deficiency; mental fatigue, anorexia, abdominal distention, loose stool, water retention, difficult urination, edema, phlegm-fluid retention, and vertigo.
Honey-fried licorice root: is prepared from radix Glycyrrhizae baked with Mel; the honey-fried licorice root is sweet in taste, has the effects of tonifying spleen and stomach, tonifying qi and recovering pulse as a tonifying medicine, and is mainly used for treating weakness of spleen and stomach, lassitude and hypodynamia, palpitation and intermittent pulse.
Erythritol: the sweetness is 70 percent of that of common cane sugar, and the sweetener has small molecular weight, most of the sweetener can be quickly absorbed in cerebellum, can not be metabolized and decomposed, is discharged out of the body along with urine, can be taken by a diabetic and has no influence on blood sugar.
Polyethylene glycol: has no irritation and slightly bitter taste, and has different properties according to different molecular weights, and the polyethylene glycol with high molecular weight can be used as excipient in the medical industry, and can even improve the capability of releasing the medicine.
In the examples described below, the erythritol is available from Shanghai Maxin Biochemical technology, inc. under the product number SJ-E808834; the corn dextrin is purchased from Shanghai Maxlin Biochemical technology, inc., and has a product number of SJ-D806744; sorbitol was purchased from remote chemical agents, ltd, tianjin; the probiotic freeze-dried powder is purchased from Teng pharmaceutical Co., ltd of Anhui; polyethylene glycol is purchased from Yuan chemical reagents, inc. of Tianjin, with a product number of 25322-66-3.
Examples 1 to 4 and comparative examples 1 to 4
The component formulations of the compositions of examples 1-4 and comparative examples 1-4 are shown in Table 1 in parts by weight.
TABLE 1
The compositions of examples 1-4 and comparative examples 1-3 in table 1 were subjected to the preparation of granular products by a method comprising the steps of:
(1) Cleaning radix Pseudostellariae, poria, atractylodis rhizoma and radix Glycyrrhizae Preparata, cutting into 0.3-0.7cm thick pieces, adding 10 times of distilled water, soaking for 30min, boiling with strong fire, and boiling with slow fire for 1 hr; filtering under reduced pressure while the solution is hot to obtain filtrate 1 and filter residue;
(2) Mixing the residue with 10 times of distilled water, boiling over strong fire, boiling over slow fire for 40min, and filtering under reduced pressure to obtain filtrate 2;
(3) Combining the filtrates obtained in the step (1) and the step (2) to obtain a total filtrate;
(4) Distilling the total filtrate under reduced pressure, concentrating to a degree of no wall built-up, centrifuging at 4 deg.C and 8000r/min for 10min, collecting supernatant to obtain clear liquid, and concentrating with evaporation pan to obtain extract with drug content of 1.5g/mL, wherein the drug content is total amount of radix Pseudostellariae, poria, atractylodis rhizoma and radix Glycyrrhizae Preparata;
(5) Uniformly mixing the extract with honey and sorbitol in parts by weight, adding probiotic freeze-dried powder, erythritol and dextrin in parts by weight as auxiliary materials, drying erythritol and corn dextrin at low temperature before use, and sieving with a No. 5 sieve to obtain dry extract for later use;
(6) Preparing acid soft materials and alkali soft materials: preparing an acid soft material: mixing the dry extract with citric acid by equivalent incremental method, and mixing with anhydrous alcohol to obtain soft acid material, wherein the soft acid material is prepared by holding into a ball and dispersing by light pressing. Preparing an alkali soft material: heating PEG-6000 at 60-80 deg.C to molten state, mixing with sodium bicarbonate, pulverizing, sieving, mixing with dry extract, and mixing with anhydrous ethanol to obtain alkali soft material; the mass ratio of the polyethylene glycol to the sodium bicarbonate is 2.
(7) Respectively sieving the acid soft material and the alkali soft material with a No. 1 sieve and a No. 5 sieve, wherein the total amount of the particle size of the acid soft material and the particle size of the alkali soft material which are larger than the No. 1 sieve and smaller than the No. 5 sieve is not more than 15%, and preparing into particles; placing the sieved granules into a preheated oven, and baking at 30-50 deg.C for 60-120min, wherein, turning over every 30min, and controlling the water content to be lower than 2%; and uniformly mixing the dried acid soft material particles and the dried alkali soft material particles according to the mass ratio of 1.
Preparation method of composition granules of comparative example 4:
the granular product of the composition of comparative example 4, which does not contain PEG, was prepared by directly mixing with parts by weight of sodium bicarbonate and absolute ethanol during the preparation of the soft alkali material, without coating with PEG.
Comparative example 5
Different from the example 1, the composition of the comparative example does not contain the probiotic freeze-dried powder, and the preparation methods of the rest components and granules are the same as the example 1.
Comparative example 6
In contrast to example 1, in the composition of this comparative example, the extract: dextrin: the weight part ratio of the erythritol is 1.
Test 1 evaluation
1.1 evaluation of shape under high temperature conditions
Storage conditions were as follows: the composition granules prepared in examples 1 to 4 and comparative examples 1 to 6 were spread at 60 ℃ under a relative humidity of 30%, and sampled on days 0, 7 and 14 to evaluate the shape. The evaluation results are shown in Table 2.
TABLE 2
1.2 dissolution evaluation
The dissolution rate is determined by checking soluble granule in pharmacopoeia of the people's republic of China (2020 edition). The sample (10 g under 1.1 shape evaluation at high temperature) is added with 200ml of hot water at 65 deg.C, stirred for 5min, immediately observed, and completely dissolved or suspended. All particles were completely dissolved, and slight turbidity was allowed to pass; or the suspended particles can be uniformly suspended to be qualified; otherwise, the product is not qualified. The evaluation results are shown in Table 3.
TABLE 3
| Day 0 | Day 7 | Day 14 | |
| Example 1 | Qualified | Qualified | Qualified |
| Example 2 | Qualified | Qualified | Qualified |
| Example 3 | Qualified | Qualified | Qualified |
| Example 4 | Qualified | Qualified | Qualified |
| Comparative example 1 | Qualified | Qualified | Qualified |
| Comparative example 2 | Qualified | Qualified | Qualified |
| Comparative example 3 | Qualified | Qualified | Qualified |
| Comparative example 4 | Qualified | Qualified | Qualified |
| Comparative example 5 | Qualified | Qualified | Qualified |
| Comparative example 6 | Qualified | Qualified | Qualified |
1.3 sensory evaluation
Sensory evaluation of smell, color and taste was performed on the composition granules prepared in examples 1 to 4 and comparative examples 1 to 6.
Evaluation of the population: 20 healthy people of 18-60 years old; wherein, 10 male, 10 female, non-pregnant woman and lactating mother; no other metabolic diseases, digestive system diseases, endocrine system diseases, mental diseases and the like; no history of allergy and intolerance to the food to be tested; nutrient supplements affecting glucose tolerance, oral contraceptives, acetylsalicylic acid, steroids, protease inhibitors and antipsychotics are not taken for nearly 3 months. And (5) uniformly carrying out professional sensory evaluation training.
Taking 10g of the granule preparation, adding 200mL of 65 deg.C hot water, stirring for 5min, and drinking. The evaluation is given, the evaluation criteria are shown in table 4, the evaluation results are shown in table 5, and the numbers in table 5 represent: of the 20 evaluators, some of the evaluators considered that the odor, color and taste belonged to category 1, category 2, category 3 or category 4, respectively.
TABLE 4
TABLE 5
Experiment 2 animal experiments
Test animals: the Kunming mice are 110, half of each male and female, 25-30g in weight, 6-8 weeks old, are bred adaptively for one week and then are tested, and are randomly grouped, wherein each group comprises 10 mice:
(1) Blank group: normal saline for drenching
(2) Sample group: the granules of examples 1 to 4 and comparative examples 1 to 6 were made into a solvent of 0.2g/mL and administered to mice.
The intragastric administration dosage of all groups is 0.2mL/10g; drench continuously for 10 days, 8 as early as each day: 00 drenching.
2.1 measurement of growth Performance
Average Daily Gain (ADG): mice were weighed on an empty stomach at the beginning and end of the experiment.
Mean daily gain mass = (end weight-initial weight)/number of days tested.
The results are shown in Table 6.
2.2 immunoglobulin assay
The food is fasted in the last day of the experiment, the eyeball is picked for blood collection, the blood is centrifuged at 3000r/min and 4 ℃ for 10min, the serum is separated, and the serum is subpackaged in a 1mL centrifuge tube for freezing and preservation.
Serum immunoglobulin IgG (ng/ml) was measured according to the kit instructions and the results are shown in Table 6.
2.3 immune organ index determination
On the last day of the experiment, after blood collection is completed, the mice after blood collection treatment are killed (the mice are directly collected after blood collection is completed), the spleen is taken, and fat and tissues are removed and weighed. And quickly weighing the spleen with fat removed, and calculating the spleen index. The results are shown in Table 6.
Spleen index (mg/10 g) = spleen weight (mg)/body weight (g) = 10.
TABLE 6
| Average daily gain g/d | Immunoglobulin IgG | Spleen index mg/10g | |
| Example 1 | 1.01 | 829.7 | 38.4 |
| Example 2 | 0.86 | 814.6 | 36.0 |
| Example 3 | 0.95 | 806.5 | 36.9 |
| Example 4 | 0.91 | 812.3 | 36.7 |
| Comparative example 1 | 0.78 | 750.9 | 34.3 |
| Comparative example 2 | 0.81 | 768.3 | 34.5 |
| Comparative example 3 | 0.84 | 771.2 | 34.9 |
| Comparative example 4 | 0.84 | 763.8 | 36.7 |
| Comparative example 5 | 0.81 | 756.8 | 34.7 |
| Comparative example 6 | 0.85 | 774.5 | 35.8 |
| Blank group | 0.75 | 726.4 | 32.7 |
Finally, it should be noted that the above-mentioned contents are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, and that the simple modifications or equivalent substitutions of the technical solutions of the present invention by those of ordinary skill in the art can be made without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. A composition comprising the following components: radix pseudostellariae, poria cocos, bighead atractylodes rhizome, honey-fried licorice root, erythritol, dextrin, sorbitol, honey, citric acid, probiotic freeze-dried powder, polyethylene glycol and sodium bicarbonate.
2. The composition according to claim 1, characterized in that it comprises the following components in parts by weight: 1-5 parts of radix pseudostellariae, 1-5 parts of poria cocos, 1-5 parts of bighead atractylodes rhizome, 1-4 parts of honey-fried licorice root, 10-20 parts of erythritol, 10-16 parts of dextrin, 2-4 parts of sorbitol, 2-4 parts of honey, 0.1-0.5 part of citric acid, 1-5 parts of probiotic freeze-dried powder, 1-4 parts of polyethylene glycol and 1-2 parts of sodium bicarbonate.
3. The composition according to claim 2, characterized in that it comprises the following components in parts by weight: 3-4 parts of radix pseudostellariae, 2-4 parts of poria cocos, 2-4 parts of bighead atractylodes rhizome, 2-3 parts of honey-fried licorice root, 12-16 parts of erythritol, 12-15 parts of dextrin, 2-3 parts of sorbitol, 2-3 parts of honey, 0.1-0.3 part of citric acid, 1-4 parts of probiotic freeze-dried powder, 2-4 parts of polyethylene glycol and 1-1.5 parts of sodium bicarbonate.
4. The use of the composition of any one of claims 1-3 in the preparation of a product with the functions of nourishing yin, promoting the production of body fluid, replenishing qi to invigorate the spleen and enhancing immunity.
5. A product having the functions of nourishing yin, promoting the production of body fluid, supplementing qi, strengthening the spleen and enhancing immunity, which comprises the composition of any one of claims 1 to 3.
6. The product of claim 5, wherein the product is in a dosage form selected from the group consisting of granules, powders, tablets, drinks, effervescent agents, pills.
7. A process for the preparation of granules containing a composition according to any one of claims 1 to 3, comprising the steps of:
(1) Soaking radix Pseudostellariae, poria, atractylodis rhizoma, and radix Glycyrrhizae Preparata in water, boiling, and filtering to obtain filtrate 1 and residue;
(2) Adding water into the filter residue obtained in the step (1) continuously, boiling, and filtering to obtain a filtrate 2;
(3) Mixing the filtrate 1 and the filtrate 2 to obtain a total filtrate;
(4) Concentrating the total filtrate obtained in the step (3), and continuously concentrating the supernatant to obtain an extract;
(5) Mixing the extract with Mel and sorbitol, adding erythritol and dextrin to obtain dry extract;
(6) Dividing the dry extract into two parts, mixing one part with citric acid, and mixing with ethanol to obtain soft acidic material; mixing the other part with mixture of sodium bicarbonate and polyethylene glycol, and mixing with ethanol to obtain soft alkaline material;
(7) Sieving the acid soft material and the alkali soft material respectively, granulating, oven drying, and mixing to obtain composition granule.
8. The method according to claim 7, wherein in steps (1) to (2), the boiling is specifically: the weight ratio of the radix pseudostellariae, the tuckahoe, the white atractylodes rhizome, the honey-fried licorice root and the water is 1 to 20, the soaking is carried out for 20 to 90min, the mixture is boiled with big fire, then the mixture is boiled with small fire and kept for 0.5 to 2h, and the hot mixture is filtered; in the step (4), the medicine content of the extract is 0.5-3g/mL, and the medicine content is the total amount of radix pseudostellariae, poria cocos, bighead atractylodes rhizome and honey-fried licorice root; in the step (5), the mass ratio of the extract to the dextrin to the erythritol is 1.5-4.
9. The preparation method according to claim 7, wherein in the step (6), the soft acid material is prepared by: mixing the dry extract and citric acid uniformly by equivalent incremental method, and mixing with anhydrous alcohol to obtain soft acid material; the preparation of the alkali soft material is specifically as follows: mixing the dry extract with a mixture of sodium bicarbonate and polyethylene glycol, and mixing with anhydrous ethanol to obtain an alkali soft material; the acid soft material and the alkali soft material are prepared by being held into a ball by hand and being scattered by light pressing; the mixture of sodium bicarbonate and polyethylene glycol is sodium bicarbonate coated by polyethylene glycol: heating polyethylene glycol at 60-80 deg.C to molten state, mixing with sodium bicarbonate, pulverizing, and sieving; the mass ratio of the polyethylene glycol to the sodium bicarbonate is 1-3.
10. The preparation method according to claim 7, wherein in the step (7), the sieving is performed by using a No. 1 sieve and a No. 5 sieve, and the total amount of the sieve with the particle size larger than the No. 1 sieve and the sieve with the particle size smaller than the No. 5 sieve is not more than 15%; the drying is specifically to put the sieved particles into a preheated oven, and dry the particles for 60 to 120min at the temperature of 30 to 50 ℃, wherein the water content is controlled to be lower than 2 percent when the particles are turned over every 30 min; and uniformly mixing the dried particles prepared from the acid soft material and the alkali soft material according to the mass ratio of 1.
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