CN108671148A - A kind of dendrobium candidum leaf effervescent and preparation method thereof - Google Patents
A kind of dendrobium candidum leaf effervescent and preparation method thereof Download PDFInfo
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- CN108671148A CN108671148A CN201810411572.7A CN201810411572A CN108671148A CN 108671148 A CN108671148 A CN 108671148A CN 201810411572 A CN201810411572 A CN 201810411572A CN 108671148 A CN108671148 A CN 108671148A
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The present invention provides a kind of dendrobium candidum leaf effervescents and preparation method thereof.The preparation method includes step：1) preparation of dendrobium candidum leaf total flavone extract dry powder；2) preparation of effervescent.The beneficial effects of the invention are as follows：(1) flavones ingredient extraction in dendrobium candidum leaf is separated and is prepared into effervescent, can preferably play the effect of active ingredient in leaf.(2) lactose for selecting hygroscopicity smaller is as diluent, use equivalent gradually-increased by the auxiliary materials and mixings such as dendrobium candidum leaf extract dry powder and lactose simultaneously, on the one hand the hygroscopicity for reducing particle and main ingredient, on the other hand makes main ingredient be uniformly dispersed, ensures the homogeneity of preparation.In addition, separately pelletizing using PEG6000 encapsulated sodium bicarbonates, and soda acid particle, it can be effectively isolated acid source and carbon dioxide source in this way, ensured the stabilization of preparation.
Description
Technical field
The present invention relates to medical preparation technical field, more particularly to a kind of dendrobium candidum leaf effervescent and its system
Preparation Method.
Background technology
The stem of noble dendrobium is common rare traditional Chinese medicine, has nourishing Yin and clearing heat, the beneficial stomach that promotes the production of body fluid, moistens the lung and relieve the cough, improving eyesight salubrity and other effects.Iron
The skin stem of noble dendrobium is the top grade in medicinal dendrobium, just possesses the good reputation of " gold in medicine " since ancient times.Pass through the side of artificial growth at present
Formula has been resolved the rare problem of dendrobium officinale.Regulation dendrobium candidum is used as medicine with stem in Chinese Pharmacopoeia.In the picking fresh item of stem
While, the total output of the dendrobium candidum leaf of excision accounts for about the 80% of fresh total output.As dis-medicinal part, dendrobium candidum leaf
It is usually discarded, causes the serious wasting of resources.People start to appeal this to dendrobium candidum rareness species resource in imminent danger into
Row deeper into research and be subject to more rational and efficient uses.
In recent years, it has been found that dendrobium candidum leaf has significantly hypertension, hyperlipidemia, hyperglycemia, cardio-cerebrovascular diseases
Auxiliary curative effect.Flavonoid substances are a kind of natural anti-oxidation ingredients with various active, in cardiovascular, anti-aging etc.
It is widely used.Research finds flavones content in dendrobium candidum leaf close to being 3 times of stem, and with preferable anti-oxidant energy
Power, if using flavone c-glycoside content and antioxidant activity as index, dendrobium candidum leaf and flower be used as medicine instead of stem have it is certainly possible.To iron
The research of skin stem of noble dendrobium leaf is seldom, and the product of exploitation is also few.
Invention content
The existing active ingredient commercialized degree about dendrobium candidum leaf is relatively low, and lacking can be in order to the system taking and absorb
Agent.The purpose of the present invention is to provide a kind of preparation methods of dendrobium candidum leaf effervescent.
A kind of preparation method of dendrobium candidum leaf effervescent, including step：
1) preparation of dendrobium candidum leaf total flavone extract dry powder：
1-1) the dry dendrobium candidum leaf to constant weight is smashed to pieces and is pulverized, petroleum ether Soxhlet extractor is added, 80
Reflux degreasing is to colourless in DEG C water-bath；
1-2) powder after degreasing is set and volatilizes petroleum ether in evaporating dish, is then set in 250ml conical flask with cover, is added
80% ethyl alcohol carries out ultrasonic extraction；
1-3) vacuum pump filters, and filter residue repeats extraction to colourless, merging filtrate, and the vacuum rotary steam at 55 DEG C obtains iron sheet
Stem of noble dendrobium leaf total flavonoids extract, up to dry powder after the medicinal extract of gained is freeze-dried；
2) preparation of effervescent：
It 2-1) takes lactose, dendrobium candidum leaf total flavone extract dry powder to crush respectively, crosses 80 mesh sieve, be respectively divided into 2 parts, it is standby
With；
It 2-2) takes PEG6000, after heating and melting, sodium bicarbonate is added, mixing is cooling, smashes it through 80 mesh sieve, spare；
It takes dendrobium candidum leaf total flavone extract dry powder in mortar, the carbonic acid of lactose and PEG6000 packages is added by equivalent gradually-increased
Hydrogen sodium mixing, appropriate 70% ethyl alcohol of addition are mixed and made into softwood, cross 18 mesh sieve and squeeze granulation, set drying in 60 DEG C of baking ovens, cross 18
Mesh sieve weeds out fine powder after 65 mesh, obtains alkali grain；
It 2-3) takes dendrobium candidum leaf total flavone extract dry powder in mortar, lactose and citric acid is added by equivalent gradually-increased
Mixing, appropriate 70% ethyl alcohol of addition are mixed and made into softwood, cross 18 mesh sieve and squeeze granulation, set drying in 60 DEG C of baking ovens, cross 18 mesh sieve
Whole grain weeds out fine powder after 65 mesh, obtains acid particles；
Alkali grain is mixed with acid particles 2-4), obtains dendrobium candidum leaf effervescent.
Wherein, the boiling range of evaporation process described in step 1-2 is 30-60 DEG C；The extraction time of the ultrasonic extraction is 35 points
Clock.
Further, drying time period of pelletizing described in step 2-2 and 2-3 is 1 hour.
The invention also discloses by the dendrobium candidum leaf effervescent obtained by above-mentioned preparation method.
Compared with prior art, the beneficial effects of the invention are as follows：
(1) flavones ingredient extraction in dendrobium candidum leaf is separated and is prepared into effervescent, can preferably sent out
Wave the effect of active ingredient in leaf.
(2) lactose for selecting hygroscopicity smaller is extracted dendrobium candidum leaf as diluent, while using equivalent gradually-increased
The auxiliary materials and mixings such as object dry powder and lactose, on the one hand reduce the hygroscopicity of particle and main ingredient, on the other hand main ingredient are made to be uniformly dispersed,
Ensure the homogeneity of preparation.In addition, separately pelletizing using PEG6000 encapsulated sodium bicarbonates, and soda acid particle, can have in this way
Acid source and carbon dioxide source has been isolated in effect ground, ensures the stabilization of preparation.
Specific implementation mode
In the examples where no specific technique or condition is specified, according to technology or condition described in document in the art or
Person carries out according to product description.Reagents or instruments used without specified manufacturer, being can be by the normal of acquisition purchased in market
Advise product.
Embodiment 1
A kind of preparation method of dendrobium candidum leaf effervescent, including step：
1) preparation of dendrobium candidum leaf total flavone extract dry powder：
1-1) the dry dendrobium candidum leaf to constant weight is smashed to pieces and is pulverized, petroleum ether Soxhlet extractor is added, 80
Reflux degreasing is to colourless in DEG C water-bath；
1-2) powder after degreasing is set and volatilizes petroleum ether in evaporating dish, is then set in 250ml conical flask with cover, is added
80% ethyl alcohol carries out ultrasonic extraction；
1-3) vacuum pump filters, and filter residue repeats extraction to colourless, merging filtrate, and the vacuum rotary steam at 55 DEG C obtains iron sheet
Stem of noble dendrobium leaf total flavonoids extract, up to dry powder after the medicinal extract of gained is freeze-dried；
2) preparation of effervescent：
It 2-1) takes lactose, dendrobium candidum leaf total flavone extract dry powder to crush respectively, crosses 80 mesh sieve, be respectively divided into 2 parts, it is standby
With；
It 2-2) takes PEG6000, after heating and melting, sodium bicarbonate is added, mixing is cooling, smashes it through 80 mesh sieve, spare；
It takes dendrobium candidum leaf total flavone extract dry powder in mortar, the carbonic acid of lactose and PEG6000 packages is added by equivalent gradually-increased
Hydrogen sodium mixing, appropriate 70% ethyl alcohol of addition are mixed and made into softwood, cross 18 mesh sieve and squeeze granulation, set drying in 60 DEG C of baking ovens, cross 18
Mesh sieve weeds out fine powder after 65 mesh, obtains alkali grain；
It 2-3) takes dendrobium candidum leaf total flavone extract dry powder in mortar, lactose and citric acid is added by equivalent gradually-increased
Mixing, appropriate 70% ethyl alcohol of addition are mixed and made into softwood, cross 18 mesh sieve and squeeze granulation, set drying in 60 DEG C of baking ovens, cross 18 mesh sieve
Whole grain weeds out fine powder after 65 mesh, obtains acid particles；
Alkali grain is mixed with acid particles 2-4), obtains dendrobium candidum leaf effervescent.
Claims (5)
1. a kind of preparation method of dendrobium candidum leaf effervescent, it is characterised in that including step：
1) preparation of dendrobium candidum leaf total flavone extract dry powder：
1-1) the dry dendrobium candidum leaf to constant weight is smashed to pieces and is pulverized, petroleum ether Soxhlet extractor is added, in 80 DEG C of water
Degreasing is flowed back in bath to colourless；
1-2) powder after degreasing is set and volatilizes petroleum ether in evaporating dish, then sets in 250ml conical flask with cover, is added 80%
Ethyl alcohol carries out ultrasonic extraction；
1-3) vacuum pump filters, and filter residue repeats extraction to colourless, merging filtrate, and the vacuum rotary steam at 55 DEG C obtains dendrobium candidum
Leaf total flavonoids extract, up to dry powder after the medicinal extract of gained is freeze-dried；
2) preparation of effervescent：
It 2-1) takes lactose, dendrobium candidum leaf total flavone extract dry powder to crush respectively, crosses 80 mesh sieve, be respectively divided into 2 parts, it is spare；
It 2-2) takes PEG6000, after heating and melting, sodium bicarbonate is added, mixing is cooling, smashes it through 80 mesh sieve, spare；Take iron
The sodium bicarbonate of lactose and PEG6000 packages is added by equivalent gradually-increased in mortar for skin stem of noble dendrobium leaf total flavone extract dry powder
Mixing, appropriate 70% ethyl alcohol of addition are mixed and made into softwood, cross 18 mesh sieve and squeeze granulation, set drying in 60 DEG C of baking ovens, cross 18 mesh sieve
Whole grain weeds out fine powder after 65 mesh, obtains alkali grain；
It 2-3) takes dendrobium candidum leaf total flavone extract dry powder in mortar, lactose is added by equivalent gradually-increased and citric acid is mixed
Even, appropriate 70% ethyl alcohol of addition is mixed and made into softwood, crosses 18 mesh sieve and squeezes granulation, set drying in 60 DEG C of baking ovens, it is whole to cross 18 mesh sieve
Grain weeds out fine powder after 65 mesh, obtains acid particles；
Alkali grain is mixed with acid particles 2-4), obtains dendrobium candidum leaf effervescent.
2. the preparation method of dendrobium candidum leaf effervescent according to claim 1, it is characterised in that：Step 1-2 institutes
The boiling range for stating evaporation process is 30-60 DEG C.
3. the preparation method of dendrobium candidum leaf effervescent according to claim 1, it is characterised in that：Step 1-2 institutes
The extraction time for stating ultrasonic extraction is 35 minutes.
4. the preparation method of dendrobium candidum leaf effervescent according to claim 1, it is characterised in that：Step 2-2 and
Drying time period of pelletizing described in 2-3 is 1 hour.
5. a kind of dendrobium candidum leaf effervescent, which is characterized in that by Claims 1 to 4 any one of them preparation method
It is made.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810411572.7A CN108671148A (en) | 2018-05-02 | 2018-05-02 | A kind of dendrobium candidum leaf effervescent and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109602004A (en) * | 2018-12-21 | 2019-04-12 | 无锡食品科技园发展有限公司 | With the dendrobium candidum effervescent tablet compound and preparation method thereof for improving the immunity of the human body and protecting stomach function |
| CN110432491A (en) * | 2019-08-12 | 2019-11-12 | 上海应用技术大学 | A kind of dendrobium leaf effervescent tablet and preparation method thereof |
| CN111000734A (en) * | 2020-02-06 | 2020-04-14 | 浙江华康药业股份有限公司 | Mouthwash effervescent granules and preparation method and use method thereof |
| CN115531437A (en) * | 2022-11-01 | 2022-12-30 | 广东好味鲜菜品与营养研究所 | Composition containing radix pseudostellariae and preparation method of granules of composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617019A (en) * | 2014-11-21 | 2016-06-01 | 北京和悦众康医药研究开发有限公司 | Effervescent granule composition containing dendrobium officinale ultrafine powder |
| CN107320525A (en) * | 2017-05-27 | 2017-11-07 | 洛阳惠德生物工程有限公司 | Yellow effervescence granular of a kind of a kind of reed mentioned in ancient books and preparation method thereof |
-
2018
- 2018-05-02 CN CN201810411572.7A patent/CN108671148A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617019A (en) * | 2014-11-21 | 2016-06-01 | 北京和悦众康医药研究开发有限公司 | Effervescent granule composition containing dendrobium officinale ultrafine powder |
| CN107320525A (en) * | 2017-05-27 | 2017-11-07 | 洛阳惠德生物工程有限公司 | Yellow effervescence granular of a kind of a kind of reed mentioned in ancient books and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 李艳萍等: "金钗石斛叶中总黄酮的提取分离及体外抗阿尔茨海默病活性研究", 《中国药房》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109602004A (en) * | 2018-12-21 | 2019-04-12 | 无锡食品科技园发展有限公司 | With the dendrobium candidum effervescent tablet compound and preparation method thereof for improving the immunity of the human body and protecting stomach function |
| CN110432491A (en) * | 2019-08-12 | 2019-11-12 | 上海应用技术大学 | A kind of dendrobium leaf effervescent tablet and preparation method thereof |
| CN111000734A (en) * | 2020-02-06 | 2020-04-14 | 浙江华康药业股份有限公司 | Mouthwash effervescent granules and preparation method and use method thereof |
| CN115531437A (en) * | 2022-11-01 | 2022-12-30 | 广东好味鲜菜品与营养研究所 | Composition containing radix pseudostellariae and preparation method of granules of composition |
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