CN104998019B - A kind of promoting blood circulation and removing blood stasis, Chinese medicine composition of hemostasis and pain-relieving - Google Patents
A kind of promoting blood circulation and removing blood stasis, Chinese medicine composition of hemostasis and pain-relieving Download PDFInfo
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Abstract
The present invention relates to a kind of promoting blood circulation and removing blood stasis, Chinese medicine compositions of hemostasis and pain-relieving, which is characterized in that the composition is prepared by following Chinese medicine material medicine：The short top top of Paris polyphylla, wild aconite root, ginger peel, tuniclike psammosilene root drape over one's shoulders numb grass, Chinese yam, Stephania epigaea, Bleeding-Stopping Bolus, rhizoma polygoni paleacei, vomiting nut, datura alba Nees, application the invention further relates to the preparation method of Chinese medicine composition and clinically, Chinese medicine composition of the present invention is in prescription, processing procedure and application is upper has prescription rationally unique, simple for process, clinical application extensive and the advantages such as market value is high.
Description
Technical field
The present invention relates to a kind of promoting blood circulation and removing blood stasis, Chinese medicine compositions of hemostasis and pain-relieving, especially contain Paris polyphylla and vomiting nut etc.
The Chinese medicine composition of prescriptions of traditional Chinese medicine further relates to the preparation method of the Chinese medicine composition, additionally relates to the Chinese medicine composition and is facing
Application on bed.
Technical background
Chinese medicine refers to the drug applied under Han nationality's folk medicine guidance.Chinese medicine is divided into Chinese patent drug, Chinese medicine by processing technology
Material.Chinese medicine is originating primarily from China, other than autonomic drug, animal drugs such as snake gall, and bear gall, long-noded pit viper, pilose antler, deer horn etc.；It is situated between
Shell class such as pearl, concha meretricis seu cylinae；Mineral substance such as keel, magnetite etc. are all the Chinese medicine for curing the disease.A small number of Chinese medicines are derived from foreign country, such as west
American ginseng.
Since founding of New, great attention of the Chinese government to traditional Chinese medicine, formulated with unity traditional Chinese and western medicine and after
It holds traditional Chinese medicine and pharmacy and is the Chinese medical policy of core, and take a series of effective measure Developing TCM causes.With modern natural
Therefore science and China's economic, culture, the rapid development of educational undertaking, Chinese pharmacology also achieve rapid progress.
Successively repeatedly organizational strength resource has carried out large-scale inquiry and the collection of data for government.These achievements are most of all
It is reflected in the whole nation and the works such as various regions Chinese medicinal herbal or medicinal plant will, fauna.Know that natural resources of Chinese medicinal materials sum has 12807
Kind, wherein with 11146 kinds of plant, 1581 kinds of medicinal animal, 80 kinds of mineral drug.On the basis of natural resources of Chinese medicinal materials is investigated, some into
The utilization of the mouth domestic resource of medicinal material also achieve important achievement, such as devilpepper, styrax, agalloch eaglewood produce at home.
Natural resources of Chinese medicinal materials protection, autonomic drug strange land are introduced a fine variety, medicinal animal and the domestication of medicinal animal and the comprehensive utilization of Chinese medicine are also quite shown in into
Effect.American Ginseng, Rhizoma Gastrodiae, pilose antler, bear gall and ginseng, uncaria etc. are just the typical example in terms of these respectively.
For Chinese medicine in the case where country encourages development and protection, national secrecy prescription occur Yunnan Baiyao, Pien Tze Huang, cow-bezoar
Pacify palace ball.It is wherein the most famous with Yunnan Baiyao.
It is much the effect of hemostasis that Yunnan Baiyao, which is in the public eye, and since it contains a variety of active ingredients, pharmacological action is multiple
It is miscellaneous, there is multiple use in addition to hemostasis.
Yunnan Baiyao has a variety of hemorrhagic diseases apparent curative effect, can accelerate hemostasis, shorten the course of disease.There is research
Show that pharmacological action mainly shortening bleeding time and clotting time, the Yunnan Baiyao of this respect can make prothrombin time contract
It is short, increase prothrombin content, and can induce the aggregation and release of blood platelet.Also apply in terms of hemostasis it is very extensive, for wound
Hinder bleeding, hemorrhage of digestive tract, hemorrhage in respiratory tract, hemorrhagic encephalopathy, gynaecology, paediatrics, ENT dept.'s hemorrhagic disease have very well
Therapeutic effect.
Yunnan Baiyao has inhibiting effect to the release of anti-inflammatory agent, for improving the sides such as microcirculation, change vasopermeability
Face is all effective.In treating wound, local red and swollen heat pain can be effectively treated, it is promoting blood circulation and removing blood stasis, inhibit swelling.In addition Yunnan
Baiyao also has antibacterial effect, can prevent the infection of wound.
Yunnan Baiyao can promote the secretion of cortex hormone of aadrenaline, have therapeutic effect for disease of immune system.
Wherein, in 1902 by Yunnan name doctor's Qu Huanzhang initiatives, Qu Dujia grasps it and is formulated simultaneously secret prepare Yunnan Baiyao.
Nineteen fifty-five, bent household have dedicated " Yunnan Baiyao " secret recipe to government.Yunnan Baiyao is matched by 1984 Nian8Yue State Pharmaceutical Administrations
Side, technique are included in national top secret.
There are many Chinese medicine preparation of effect similar with Yunnan Baiyao, the Chinese medicine preparation as described in following Chinese patent：
But the prior art does not show the remarkable efficacy of Yunnan Baiyao still in practice, and to find, curative effect is beneficial to match
Side, the present inventor have developed a kind of new match on the basis of the third generation of Qu Huanzhang successor is improved according to the secret recipe of Qu Huanzhang
Side.
Prescription of the present invention is exactly the secret prescription handed down in the family from generation to generation and proved recipe of traditional Chinese medicine man Qu Huanzhang.Traditional Chinese medicine man Qu Huanzhang
" baiyao " or " cure-all " serial secret recipe, proved recipe are referred to as in (1880~1938), all one's life invention initiative, and what is only had good grounds is included in
《The big pharmacies Qu Huanzhang》Instructions for the use of an article sold register just has more than 20 to plant, and effect is clear, and curative effect is peculiar, and living person is countless, is famous at home and abroad,
Authorities' high level appreciation is firmly got, is made that major contribution for China's Chinese Traditional Medicine cause, this is that have Shi Weiju, stands history and examines
Card.
Invention content
It is an object of the present invention to provide a kind of promoting blood circulation and removing blood stasis, Chinese medicine compositions of hemostasis and pain-relieving.
The Chinese medicine composition, the short top top of Paris polyphylla, wild aconite root, ginger peel, tuniclike psammosilene root drape over one's shoulders numb grass, Chinese yam, Stephania epigaea, change blood
Pellet, rhizoma polygoni paleacei, vomiting nut, datura alba Nees.
This prescription according to monarch, minister, help, make principles of formulating prescriptions reasonable compatibility and obtain, it is specific as follows：
With Paris polyphylla it is monarch drug in a prescription in we.Paris polyphylla also known as paris polyphylla.Bitter, cold nature enter Liver Channel blood system, have good detumescence
The effect of analgesic, removing blood stasis and hemostasis, to treat traumatic hemorrhage, traumatic injury, the good medicine of blood stasis and swelling pain.And this product hardship is let out with dropping, and is trembled with fear
Energy heat-clearing, clearing heat and detoxicating work(show, therefore are also one of sore swollen toxin one kind disease choice drug.In recent years, clinical discovery this product
There is good removing blood stasis and hemostasis effect to uterine hemorrhage caused by various gynecological diseases and menorrhalgia.Paris polyphylla is in this prescription
Dosage accounts for about the 60% of full side, its medicine of the status of monarch drug in a prescription can not be reached in side.
The short top top of our compatibility wild aconite root, ginger peel drapes over one's shoulders numb grass, Bleeding-Stopping Bolus, rhizoma polygoni paleacei five kinds of Chinese medicine, it is intended to assist monarch drug in a prescription weight
Building improves the effect of its removing blood stasis and analgesics hemostasis, therefore is ministerial drug altogether.Wild aconite root is the specification processed product of RADIX ACONITI KUSNEZIFFII, is paid attention in we
Compatibility this product takes it to have good analgesic effect.Through the ages, wild aconite root be treatment traumatic injury, pain caused by ecchymoma of fracturing it is normal
With one of analgesic drug product.Though this product is toxic, its toxicity subtracts greatly after processing, and dosage is light in prescription, in prescribed dose Inner
It takes, safety can be guaranteed.In addition, though this product pharmacological property is pungent, big heat, with large dosage is bitter, after cold (cool) medicine compatibility
With using, complete the be in heat-clearing toxin-expelling functions in side are influenced little.The short top top of ginger peel also known as pea seven.For Shaanxi, Gansu, Hubei, four
The traditional herbal medicine on the ground such as river.According to《Shaanxi Chinese herbal medicine》It records：This product is bitter, puckery, cool, can " hemostasis, analgesia, strengthening tendons, long bone.It controls and falls
Beat damage, fracture.”《Hubei Chinese herbal medicine》：" removing blood stasis and analgesics, removing toxic substances.”《Qinling Mountains Bashan Mountain natural drug will》：" irregular menstruation is cured mainly,
Dysmenorrhoea." therefore the major function of this product may be summarized to be removing blood stasis and analgesics, stop blooding.Suitable for traumatic injury, fracture, traumatic hemorrhage, the moon
Through uncomfortable, dysmenorrhoea etc..Compatibility this product purpose in side mainly strengthens monarch drug in a prescription removing blood stasis and analgesics hemostasia effect.Numb grass is draped over one's shoulders, is Liliaceae
The root and rhizome of Veratrum Dali black false hellebore Veratrum taliensis Loes.f., just entitled Dali black false hellebore.For Yunnan
Local traditional herbal medicine.This product is pungent, bitter, trembles with fear.Function eliminating stasis to subdue swelling, pain easing and hemostasis are used for traumatic injury, fracture, traumatic bleeding etc..
Compatibility this product in side is also intended to strengthen the effect that monarch drug in a prescription dissipates stasis of blood pain easing and hemostasis.Bleeding-Stopping Bolus, be southwest, Shaanxi, etc. regional civil grass
Medicine, runcinate knotweed herb of rectifying name, first recorded in《The Illustrated Book on Plants》, it is polygonaceae plant runcinate knotweed herb Polygonum runcinatum
The herb of Buch.-Harn.ex D.Don.It is pharmacological property slight bitter, puckery, it puts down.With promoting blood circulation and hemostasis, removing toxicity for detumescence function.《National medium-height grass
Medicine collects》：" promoting blood circulation and hemostasis.Haematemesis is cured mainly, is spat blood, hemorrhoid hemorrhoid hemorrhage.”《The civil prescription collection in Guizhou》：" control hemorrhoid, nine sub- ulcers；With
In traumatic injury, relaxing tendons and activating collaterals, synthetism, the wound that disappears is swollen, only grieved." rhizoma polygoni paleacei, it is Yunnan, Southwest Sichuan area traditional herbal medicine, is
The rhizome of polygonaceae arsesmart rhizoma polygoni paleacei Polygonum paleaceum Wall..This product bitter, acrid, cold.With the scattered stasis of blood, stop blooding,
Promoting qi circulation and relieving pain effect.《Traditional Chinese Medicine in Sichuan will》：" be used for traumatic injury, spit blood, bleeding from five sense organs or subcutaneous tissue, dysentery, carbuncle sore tumefacting virus ",《National Chinese herbal medicine
Compilation》：" controlling chronic gastritis, taste-blindness rate, enteritis, irregular menstruation, traumatic injury ".Above-mentioned prescription analysis shows system
The five kinds of Chinese medicine such as radix aconiti agrestis enhance the function of monarch drug in a prescription Paris polyphylla on promoting blood circulation to remove blood stasis, analgesic hemostatic and the several levels of removing toxicity for detumescence respectively,
The effect of analgesic hemostatic detumescence is improved, therefore is ministerial drug in side altogether.
Vomiting nut (system) in side, Stephania epigaea, datura alba Nees seed, the four traditional Chinese medicines such as tuniclike psammosilene root are adjutant altogether.Vomiting nut (system)
For the seed of Loganiaceae Poisonnut plant Strychnos nux-vomica Strychnos nux-vomica L..Bitter, it is cold in nature.With removing obstruction in channels to relieve pain,
Powder detoxifcation effect.《Go here and there refined benefit》：" it is deep that muscle can be bored, it is active to search wind." so, this product Fang Zhongyou assist monarch drug in a prescription and ministerial drug with
Enhance its analgesic efficacy, plays the role of supplementary drug.Since health product is toxic, therefore with product, to reduce its toxicity.Stephania epigaea is
Menispermaceous plants Stephania epigaea Stephanin epigaea H.S.Lo and Yunnan Stephania epigaea Stephunia yunnanensis
The root tuber of H.S.Lo.Bitter, it is cold in nature, there is the effect of clearing heat and detoxicating, regulating qi-flowing for relieving pain.According to《Southern cloud Chinese herbal medicine》、《During Sichuan is common
Herbal medicine》Deng record, this product is mainly used for acute/chronic gastroenteritis, has a stomachache, indigestion, dyspeptic abdominalgia etc..So compatibility is few in side
Stephania epigaea is measured, the promotings qi circulation and relievings pain such as certain ministerial drugs such as rhizoma polygoni paleacei can be assisted, to treat based on gastrointestinal tract stagnation of the circulation of vital energy antalgesic, in side
Play supplementary drug.Datura alba Nees seed is the seed of Solanaceae Datura plant datura metel Datura metel L..
It is acrid in flavour and warm in nature, it is toxic.With wind-dispelling, analgesic efficacy.According to《Compendium of Materia Medica》、《Classify herbal》、《Traditional Chinese Medicine in Sichuan will》Equal documents note
It carries, is mainly used for treating rheumatoid arthrosis swelling and pain, traumatic injury etc..Tuniclike psammosilene root is Caryophyllaceae tuniclike psammosilene root platymiscium tuniclike psammosilene root
The root of Psammosilene tunicoides W.C.Wu et C.Y.Wu..Bitter, it is pungent, it is warm-natured.With scattered stasis pain, hemostasis
Function.According to《The southern regions of the Yunnan Province book on Chinese herbal medicine》、《Yunnan Chinese herbal medicine》、《Often use Chinese herbal medicine in Sichuan》Equal documents are recorded, and this product is mainly used for bruise
Damage, traumatic bleeding and has a stomach-ache, rheumatalgia pain etc..Two medicine of above-mentioned datura alba Nees seed and tuniclike psammosilene root, is both supplementary drug in side,
It is supplementary inhibitory medicine again.Not only it had helped and has helped monarch, ministerial drug analgesic, but also because of its pharmacological property partial temperature, the property that a large amount of bitter cold drugs are cold and cool in side processed can have been helped, kept away
Exempt from cold and cool excessive damage taste.
Chinese yam plays a part of to make medicine in we.This product is sweet in flavor, mild-natured.《Sheng Nong's herbal classic》：" in main wound, qi-restoratives is thin,
Except fever and chills perverse trend, tonifying middle-Jiao and Qi power.”《Compendium of Materia Medica》：" kidney-nourishing gas, strengthening the spleen and stomach." due to we it is (or pungent using a large amount of bitter colds
Temperature) toxic product, it easily kills and cuts down healthy tendency, injure taste, therefore this product of compatibility sweet in flavor and neutral in nature, sugariness medicine can be mended, can and can delay, with
Mitigate injury of all medicines to spleen and stomach function, mitigate the bias of all medicines, plays the role of coordinating the drug actions of a prescription, therefore to make medicine in side.
For this purpose, the present invention provides a kind of promoting blood circulation and removing blood stasis, Chinese medicine composition of hemostasis and pain-relieving, which is characterized in that the combination
Object is prepared by following Chinese medicine material medicine：The short top top of Paris polyphylla, wild aconite root, ginger peel, tuniclike psammosilene root, drape over one's shoulders numb grass, Chinese yam, Stephania epigaea,
Bleeding-Stopping Bolus, rhizoma polygoni paleacei, vomiting nut, datura alba Nees.
Chinese medicine composition of the present invention, the preferred composition prepared by the Chinese medicine material medicine of following proportioning and
At：
| Title | Weight | Title | Weight | Title | Weight |
| Paris polyphylla | 0-800g | Wild aconite root | 0-100g | The short top top of ginger peel | 0-50g |
| Tuniclike psammosilene root | 0-30g | Drape over one's shoulders numb grass | 0-10g | Chinese yam | 0-20g |
| Stephania epigaea | 0-2g | Bleeding-Stopping Bolus | 0-50g | Rhizoma polygoni paleacei | 0-50g |
| Semen Strychni (processed) | 0-50g | Datura alba Nees | 0-50g。 |
Chinese medicine composition of the present invention, the preferred composition prepared by the Chinese medicine material medicine of following proportioning and
At：
Chinese medicine composition of the present invention, the most preferred composition prepared by the Chinese medicine material medicine of following proportioning and
At：
| Title | Weight | Title | Weight | Title | Weight |
| Paris polyphylla | 240g | Wild aconite root | 50g | The short top top of ginger peel | 25g |
| Tuniclike psammosilene root | 12g | Drape over one's shoulders numb grass | 2g | Chinese yam | 13g |
| Stephania epigaea | 1.9g | Bleeding-Stopping Bolus | 20g | Rhizoma polygoni paleacei | 20g |
| Semen Strychni (processed) | 20g | Datura alba Nees | 20g。 |
In composition described above, the weight of each taste medicine is calculated with crude drug, can be increased or subtract according to corresponding proportion in production
It is few, as large-scale production can by kilogram as unit of, or as unit of ton, small-scale production can also with gram or milligram be single
Position, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of the above weight proportion screens to obtain by science, fat such as severe or mild for especial patient
Or the patient of slight of stature, the proportioning of the amount of composition can be accordingly adjusted, is increased or decreased no more than 100%, drug effect is constant.
The Chinese medicine preparation of the present invention is by the way that the Chinese medicine material medicinal material of above-mentioned formula composition is passed through extraction or other modes
Processing, is made pharmaceutically active substance, then, pharmaceutically acceptable carrier is added using the substance as raw material, when needing, according to preparation
Made of routine techniques.The active material can be obtained by extracting Chinese medicine material respectively, can also be by carrying jointly
It takes Chinese medicine material medicinal material to obtain, can also obtain by other means, such as：By crushing, squeezes, is ground up, sieved, diacolation, extraction
Take, water carries, alcohol extracting, ester the methods of carry, chromatograph obtain, these active materials can be medicinal extract form substance, can be dry leaching
Cream can also be liquid extract, and different according to preparation need to determine that different concentration is made.
The pharmaceutical preparation of the present invention, preferably pharmaceutical dosage form of unit dose can be with when pharmaceutical preparation is made
Any pharmaceutical dosage form is made, these dosage forms are selected from：Tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule,
Hard capsule, soft capsule, oral solution, mouth containing agent, granule, pill, powder, paste, sublimed preparation, suspension, solution, injection
Agent, suppository, ointment, emplastrum, creme, spray, patch.Preferably oral dosage form, most preferably capsule,
Granule.
The pharmaceutical preparation of the present invention, can be added some pharmaceutically acceptable carriers, galenic pharmacy may be used as needed
Routine techniques prepares the pharmaceutical preparation, such as mixes pharmaceutically active substance with pharmaceutically acceptable carrier.The drug is acceptable
Carrier be selected from：Mannitol, sorbierite, sorbic acid or sylvite, sodium pyrosulfite, sodium hydrogensulfite, sodium thiosulfate, hydrochloric acid half
Cystine, thioacetic acid, methionine, vitamin A, vitamin C, vitamin E, vitamin D, azone, EDETATE SODIUM, EDTA calcium
Sodium, the carbonate of monovalence alkali metal, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulfuric acid, phosphoric acid, amino acid, chlorination
It is sodium, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, sweet
Reveal sugar alcohol, silicon derivative, cellulose and its derivates, alginates, gelatin, polyvinylpyrrolidone, glycerine, propylene glycol, ethyl alcohol,
Soil temperature 60-80, Span-80, beeswax, lanolin, atoleine, hexadecanol, gallate ester, agar, triethanolamine, alkalinity
Amino acid, urea, allantoin, calcium carbonate, calcium bicarbonate, surfactant, polyethylene glycol, cyclodextrin, beta-cyclodextrin, phosphatide
Class material, kaolin, talcum powder, calcium stearate, magnesium stearate etc..
It is a further object of the present invention to provide the concocting method of pharmaceutical preparation pharmaceutically active substance therein, preparation sides
Method, its step are as follows：
The Chinese medicine preparation of the present invention, corresponding preparation is made according to total raw material dry powder obtained above.When medicament is made,
Pharmaceutically active substance 0.1-1000mg of the medicament of unit dose containing the present invention, remaining is pharmaceutically acceptable carrier.
Pharmaceutically acceptable carrier can be the 0.1-99.9% of total formulation weight by weight.
The pharmaceutical preparation of the present invention determines usage and dosage according to the patient's condition when in use.
Chinese medicine composition of the present invention, including peroral dosage form, exterior-applied formulation.
Chinese medicine composition of the present invention, preferably tablet, capsule, granule.
Chinese medicine composition of the present invention, preferably spray.
The preparation method of Chinese medicine composition of the present invention, which is characterized in that steps are as follows：
1) it is crushed after taking the Paris polyphylla of 35%-50% weight 3 hours dry at 80 DEG C in vacuum drying chamber, crosses 100 mesh
Sieve, is placed in the container of clean dried, labels (medicinal material dry powder I), spare.
2) the short top top of ginger peel, drape over one's shoulders numb grass, tuniclike psammosilene root, Chinese yam, 5 taste medicinal material of Stephania epigaea, together 100 DEG C in vacuum drying chamber
Under be dried under reduced pressure 3 hours after crush, sieve with 100 mesh sieve, be placed in the container of clean dried, label (medicinal material dry powder II), it is spare.
3) wild aconite root, Bleeding-Stopping Bolus, rhizoma polygoni paleacei, Semen Strychni (processed), datura alba Nees gomi herbs after crushing, is measured with 12 times
70% alcohol reflux extract 3 times, every time 1 hour；Its 70% ethanol extract, filtration, is concentrated under reduced pressure into thick medicinal extract (density ≈
1.3) it, is stored in clean, dry container, labels (thick medicinal extract I), it is spare.
4) surplus Paris polyphylla, the water measured with 10 times, 3 hours of each refluxing extraction extract 3 times；Merge the water extraction of Paris polyphylla
Liquid, filtration are concentrated under reduced pressure and are set at thick medicinal extract (d ≈ 1.3) in clean, dry container, label (thick medicinal extract II), spare.
5) above-mentioned medicinal material dry powder II and thick medicinal extract I and thick medicinal extract II are sufficiently mixed uniformly, are set dry in vacuum desiccator
(60 DEG C, be dried under reduced pressure 6 hours) crush to doing, sieve with 100 mesh sieve, set in the container of clean dried, (medicinal material dry powder of labelling
III), spare.
6) above-mentioned medicinal material dry powder I and medicinal material dry powder III are sufficiently mixed uniformly to get total raw material dry powder.
7) further according to total raw material dry powder quantity, the preparation of respective numbers is made.
The invention also includes, the application of Chinese medicine composition of the invention in the drug for preparing following purposes, the purposes
Including：Promoting blood circulation, swelling and pain relieving, the effect of hemostasis, the effect of bactericidal.
It is a still further object of the present invention to provide the application of the Chinese medicine composition clinically.
1, the special promoting blood circulation of the oral preparations power such as capsule or granule, detumescence made of prescription of the present invention stop
Bitterly, stop blooding.More specific function is：It is promoting blood circulation and removing blood stasis, hemostasis and pain-relieving.For traumatic injury, blood stasis and swelling pain, traumatic hemorrhage, stomach, ten
Hyporrhea caused by two Duodenalulcers, inflammation, sore swollen toxin and soft tissue bruise, various gynecologic blood diseases such as dysmenorrhoea, Amenorrhea, warp
Hyperhematosis, postpartum blood stasis etc..
2, the external preparations such as spray made of the Chinese medicine composition are used outside has the function of hemostasis.
3, the Chinese medicine composition has effects that certain bactericidal.
In conclusion prescription of the present invention and its Chinese medicine composition have the advantage that：
1, in prescription based on bitter and cold medicines, a small amount of pungent-warm medicine of compatibility makes its cold and cool property to help, and magical effect Chinese yam, takes its sweet
Flat property mitigates the bias of all medicines, mitigates injury of the we to spleen and stomach function.
2, it is less toxic or even nontoxic to change the Chinese medicine of larger toxicity, and prescription is safe；
3, the active Chinese medicine of the Chinese medicine composition is easy to get, and is derived from a wealth of sources；
4, the active constituent processing procedure is simple, is not necessarily to particular/special requirement；
5, the Chinese medicine composition clinical application is extensive, has prodigious market Development volue.
The advantageous effect further illustrated the present invention below by way of experimental data：
More specifically to discuss the multifunctional usage of Chinese medicine composition of the present invention, to Chinese medicine composition of the present invention
Preparation obtained has carried out zoopery, concrete outcome such as following table：
Table 1：
Table 2
Table 3
To sum up, it is proved through above-mentioned animal experiment, Chinese medicine composition of the present invention has on analgesic hemostatic promoting blood circulation and removing blood stasis
Effect is quite obtained with Yunnan Baiyao.In addition the present invention has effects that certain bactericidal really through animal experiment is authenticated.
Specific implementation mode
Further illustrated the present invention below by several specific embodiments, for involved in embodiment specific data and behaviour
Work etc. does not constitute the limitation of the claimed scope of the invention.
Embodiment 1 (capsule)
| Title | Weight | Title | Weight | Title | Weight |
| Paris polyphylla | 100g+140g | Wild aconite root | 50g | The short top top of ginger peel | 25g |
| Tuniclike psammosilene root | 12g | Drape over one's shoulders numb grass | 2g | Chinese yam | 13g |
| Stephania epigaea | 1.9g | Bleeding-Stopping Bolus | 20g | Rhizoma polygoni paleacei | 20g |
| Semen Strychni (processed) | 20g | Datura alba Nees | 20g | Microcrystalline cellulose | In right amount |
Preparation process：
1, it weighs after Paris polyphylla 100g is dried 3 hours in vacuum drying chamber at 80 DEG C and crushes in prescription ratio, cross 100 mesh
Sieve, is placed in the container of clean dried, labels (medicinal material dry powder I), spare.
2, by the short top top of the ginger peel of recipe quantity, drape over one's shoulders numb grass, tuniclike psammosilene root, Chinese yam, 5 taste medicinal material of Stephania epigaea, done together in vacuum
It crushes, sieves with 100 mesh sieve after being dried under reduced pressure 3 hours at 100 DEG C in dry case, be placed in the container of clean dried, (medicinal material is dry for labelling
Powder II), it is spare.
3, by the wild aconite root of prescription proportional quantities, Bleeding-Stopping Bolus, rhizoma polygoni paleacei, Semen Strychni (processed), the sub- gomi herbs of datura alba Nees, powder
After broken, 70% alcohol reflux measured with 12 times extracts 3 times, every time 1 hour；Its 70% ethanol extract, filtration, is concentrated under reduced pressure into
Thick medicinal extract (density ≈ 1.3) is stored in clean, dry container, is labelled (thick medicinal extract I), spare.
4, Paris polyphylla 140g is weighed in prescription ratio, the water measured with 10 times, 3 hours of each refluxing extraction extract 3 times；It closes
And the aqueous extract of Paris polyphylla, filtration are concentrated under reduced pressure and are set at thick medicinal extract (d ≈ 1.3) in clean, dry container, labelling is (thick
Medicinal extract II), it is spare.
5, above-mentioned medicinal material dry powder II and thick medicinal extract I and thick medicinal extract II are sufficiently mixed uniformly, are set dry in vacuum desiccator
(60 DEG C, be dried under reduced pressure 6 hours) crush to doing, sieve with 100 mesh sieve, set in the container of clean dried, (medicinal material dry powder of labelling
III), spare.
6, above-mentioned medicinal material dry powder I and medicinal material dry powder III are sufficiently mixed uniformly to get total raw material dry powder.
Total raw material medicinal powder is placed in grinding container, be added later appropriate amount of auxiliary materials microcrystalline cellulose (total raw material medicinal powder with it is micro-
Crystalline cellulose mixed proportion is about 4:1), ground and mixed 10-30 minutes to uniformly until.By the medicinal powder of mixing, it is distributed into 1000
In No. 1 capsule of grain.
Instructions of taking：It takes orally three times a day, one every time, eats after meal.
Embodiment 2 (tablet)
| Title | Weight | Title | Weight | Title | Weight |
| Paris polyphylla | 100g+140g | Wild aconite root | 50g | The short top top of ginger peel | 25g |
| Tuniclike psammosilene root | 12g | Drape over one's shoulders numb grass | 2g | Chinese yam | 13g |
| Stephania epigaea | 1.9g | Bleeding-Stopping Bolus | 20g | Rhizoma polygoni paleacei | 20g |
| Semen Strychni (processed) | 20g | Datura alba Nees | 20g | Microcrystalline cellulose | In right amount |
Preparation process：
1, it weighs after Paris polyphylla 100g is dried 3 hours in vacuum drying chamber at 80 DEG C and crushes in prescription ratio, cross 100 mesh
Sieve, is placed in the container of clean dried, labels (medicinal material dry powder I), spare.
2, by the short top top of the ginger peel of recipe quantity, drape over one's shoulders numb grass, tuniclike psammosilene root, Chinese yam, 5 taste medicinal material of Stephania epigaea, done together in vacuum
It crushes, sieves with 100 mesh sieve after being dried under reduced pressure 3 hours at 100 DEG C in dry case, be placed in the container of clean dried, (medicinal material is dry for labelling
Powder II), it is spare.
3, by the wild aconite root of prescription proportional quantities, Bleeding-Stopping Bolus, rhizoma polygoni paleacei, Semen Strychni (processed), the sub- gomi herbs of datura alba Nees, powder
After broken, 70% alcohol reflux measured with 12 times extracts 3 times, every time 1 hour；Its 70% ethanol extract, filtration, is concentrated under reduced pressure into
Thick medicinal extract (density ≈ 1.3) is stored in clean, dry container, is labelled (thick medicinal extract I), spare.
4, Paris polyphylla 140g is weighed in prescription ratio, the water measured with 10 times, 3 hours of each refluxing extraction extract 3 times；It closes
And the aqueous extract of Paris polyphylla, filtration are concentrated under reduced pressure and are set at thick medicinal extract (d ≈ 1.3) in clean, dry container, labelling is (thick
Medicinal extract II), it is spare.
5, above-mentioned medicinal material dry powder II and thick medicinal extract I and thick medicinal extract II are sufficiently mixed uniformly, are set dry in vacuum desiccator
(60 DEG C, be dried under reduced pressure 6 hours) crush to doing, sieve with 100 mesh sieve, set in the container of clean dried, (medicinal material dry powder of labelling
III), spare.
6, above-mentioned medicinal material dry powder I and medicinal material dry powder III are sufficiently mixed uniformly to get total raw material dry powder.
Total raw material medicinal powder is placed in grinding container, be added later appropriate amount of auxiliary materials microcrystalline cellulose (total raw material medicinal powder with it is micro-
Crystalline cellulose mixed proportion is about 4:1), ground and mixed 10-30 minutes to uniformly until.By the medicinal powder of mixing, tabletting obtains
1000 tablets.
Instructions of taking：It takes orally three times a day, one every time, eats after meal.
Embodiment 3 (granule)
| Title | Weight | Title | Weight | Title | Weight |
| Paris polyphylla | 100g+140g | Wild aconite root | 80g | The short top top of ginger peel | 20g |
| Tuniclike psammosilene root | 10g | Drape over one's shoulders numb grass | 1g | Chinese yam | 10g |
| Stephania epigaea | 1.5g | Bleeding-Stopping Bolus | 20g | Rhizoma polygoni paleacei | 23g |
| Semen Strychni (processed) | 22g | Datura alba Nees | 25g | Microcrystalline cellulose | In right amount |
Preparation method：With embodiment 1.
Instructions of taking：It takes orally three times a day, one every time, eats after meal.
Embodiment 4 (spray)
| Title | Weight | Title | Weight | Title | Weight |
| Paris polyphylla | 100g+140g | Wild aconite root | 50g | The short top top of ginger peel | 25g |
| Tuniclike psammosilene root | 12g | Drape over one's shoulders numb grass | 2g | Chinese yam | 13g |
| Stephania epigaea | 1.9g | Bleeding-Stopping Bolus | 20g | Rhizoma polygoni paleacei | 20g |
| Semen Strychni (processed) | 20g | Datura alba Nees | 20g |
Preparation method：Total raw material dry powder, each refluxing extraction of 50% ethyl alcohol 1 that dry powder is measured through 10 times again is made with embodiment 1
Hour, it extracts 2 times, then after ultraviolet disinfection, spray of bottling to obtain.
Usage：Alignment wound sprays the agent.
Embodiment 5
| Title | Weight | Title | Weight | Title | Weight |
| Paris polyphylla | 260g | Wild aconite root | 60g | The short top top of ginger peel | 30g |
| Tuniclike psammosilene root | 14g | Drape over one's shoulders numb grass | 2.5g | Chinese yam | 16g |
| Stephania epigaea | 3g | Bleeding-Stopping Bolus | 25g | Rhizoma polygoni paleacei | 25g |
| Semen Strychni (processed) | 25g | Datura alba Nees | 25g。 |
Preparation process：
1, it weighs after Paris polyphylla 120g is dried 3 hours in vacuum drying chamber at 80 DEG C and crushes in prescription ratio, cross 100 mesh
Sieve, is placed in the container of clean dried, labels (medicinal material dry powder I), spare.
2, by the short top top of the ginger peel of recipe quantity, drape over one's shoulders numb grass, tuniclike psammosilene root, Chinese yam, 5 taste medicinal material of Stephania epigaea, done together in vacuum
It crushes, sieves with 100 mesh sieve after being dried under reduced pressure 3 hours at 100 DEG C in dry case, be placed in the container of clean dried, (medicinal material is dry for labelling
Powder II), it is spare.
3, by the wild aconite root of prescription proportional quantities, Bleeding-Stopping Bolus, rhizoma polygoni paleacei, Semen Strychni (processed), the sub- gomi herbs of datura alba Nees, powder
After broken, 70% alcohol reflux measured with 12 times extracts 3 times, every time 1 hour；Its 70% ethanol extract, filtration, is concentrated under reduced pressure into
Thick medicinal extract (density ≈ 1.3) is stored in clean, dry container, is labelled (thick medicinal extract I), spare.
4, Paris polyphylla 140g is weighed in prescription ratio, the water measured with 10 times, 3 hours of each refluxing extraction extract 3 times；It closes
And the aqueous extract of Paris polyphylla, filtration are concentrated under reduced pressure and are set at thick medicinal extract (d ≈ 1.3) in clean, dry container, labelling is (thick
Medicinal extract II), it is spare.
5, above-mentioned medicinal material dry powder II and thick medicinal extract I and thick medicinal extract II are sufficiently mixed uniformly, are set dry in vacuum desiccator
(60 DEG C, be dried under reduced pressure 6 hours) crush to doing, sieve with 100 mesh sieve, set in the container of clean dried, (medicinal material dry powder of labelling
III), spare.
6, above-mentioned medicinal material dry powder I and medicinal material dry powder III are sufficiently mixed uniformly to get total raw material dry powder.
Total raw material medicinal powder is placed in grinding container, be added later appropriate amount of auxiliary materials microcrystalline cellulose (total raw material medicinal powder with it is micro-
Crystalline cellulose mixed proportion is about 4:1), ground and mixed 10-30 minutes to uniformly until.By the medicinal powder of mixing, it is distributed into 1000
In No. 1 capsule of grain.
Instructions of taking：It takes orally three times a day, one every time, eats after meal.
Embodiment 6
| Title | Weight | Title | Weight | Title | Weight |
| Paris polyphylla | 220g | Wild aconite root | 40g | The short top top of ginger peel | 20g |
| Tuniclike psammosilene root | 10g | Drape over one's shoulders numb grass | 1.5g | Chinese yam | 10g |
| Stephania epigaea | 1.5g | Bleeding-Stopping Bolus | 15g | Rhizoma polygoni paleacei | 15g |
| Semen Strychni (processed) | 15g | Datura alba Nees | 15g。 |
Preparation process：
1, it weighs after Paris polyphylla 80g is dried 3 hours in vacuum drying chamber at 80 DEG C and crushes in prescription ratio, cross 100 mesh
Sieve, is placed in the container of clean dried, labels (medicinal material dry powder I), spare.
2, by the short top top of the ginger peel of recipe quantity, drape over one's shoulders numb grass, tuniclike psammosilene root, Chinese yam, 5 taste medicinal material of Stephania epigaea, done together in vacuum
It crushes, sieves with 100 mesh sieve after being dried under reduced pressure 3 hours at 100 DEG C in dry case, be placed in the container of clean dried, (medicinal material is dry for labelling
Powder II), it is spare.
3, by the wild aconite root of prescription proportional quantities, Bleeding-Stopping Bolus, rhizoma polygoni paleacei, Semen Strychni (processed), the sub- gomi herbs of datura alba Nees, powder
After broken, 70% alcohol reflux measured with 12 times extracts 3 times, every time 1 hour；Its 70% ethanol extract, filtration, is concentrated under reduced pressure into
Thick medicinal extract (density ≈ 1.3) is stored in clean, dry container, is labelled (thick medicinal extract I), spare.
4, Paris polyphylla 140g is weighed in prescription ratio, the water measured with 10 times, 3 hours of each refluxing extraction extract 3 times；It closes
And the aqueous extract of Paris polyphylla, filtration are concentrated under reduced pressure and are set at thick medicinal extract (d ≈ 1.3) in clean, dry container, labelling is (thick
Medicinal extract II), it is spare.
5, above-mentioned medicinal material dry powder II and thick medicinal extract I and thick medicinal extract II are sufficiently mixed uniformly, are set dry in vacuum desiccator
(60 DEG C, be dried under reduced pressure 6 hours) crush to doing, sieve with 100 mesh sieve, set in the container of clean dried, (medicinal material dry powder of labelling
III), spare.
6, above-mentioned medicinal material dry powder I and medicinal material dry powder III are sufficiently mixed uniformly to get total raw material dry powder.
Total raw material medicinal powder is placed in grinding container, be added later appropriate amount of auxiliary materials microcrystalline cellulose (total raw material medicinal powder with it is micro-
Crystalline cellulose mixed proportion is about 4:1), ground and mixed 10-30 minutes to uniformly until.By the medicinal powder of mixing, it is distributed into 1000
In No. 1 capsule of grain.
Instructions of taking：It takes orally three times a day, one every time, eats after meal.
Claims (7)
1. a kind of Chinese medicine composition promoting blood circulation and removing blood stasis, hemostasis and pain-relieving, which is characterized in that the composition by following proportioning Chinese medicine
Bulk pharmaceutical chemicals are prepared：
2. Chinese medicine composition according to claim 1, which is characterized in that the composition by following proportioning Chinese medicine material
Medicine is prepared：
3. Chinese medicine composition described in claim 1, which is characterized in that the dosage form of the composition is peroral dosage form, exterior-applied formulation.
4. the Chinese medicine composition described in claim 3, which is characterized in that the dosage form of the composition is tablet, capsule or particle
Agent.
5. the Chinese medicine composition described in claim 3, which is characterized in that the dosage form of the composition is spray.
6. Chinese medicine composition as claimed in claim 1 or 2, which is characterized in that steps are as follows for the preparation method of the Chinese medicine composition：
1) it is crushed after taking the Paris polyphylla of 35%-50% 3 hours dry at 80 DEG C in vacuum drying chamber, sieves with 100 mesh sieve, it is dry to obtain medicinal material
Powder I, is placed in the container of clean dried, labelling, spare,
2) the short top top of ginger peel, drape over one's shoulders numb grass, tuniclike psammosilene root, Chinese yam, 5 taste medicinal material of Stephania epigaea, subtract at 100 DEG C in vacuum drying chamber together
It crushes, sieves with 100 mesh sieve after pressing dry dry 3 hours, obtain medicinal material dry powder II, be placed in the container of clean dried, label, it is spare,
3) wild aconite root, Bleeding-Stopping Bolus, rhizoma polygoni paleacei, Semen Strychni (processed), datura alba Nees gomi herbs after crushing, is measured with 12 times
70% alcohol reflux extracts 3 times, every time 1 hour；70% ethanol extract is taken, is filtered, is concentrated under reduced pressure into thick medicinal extract, obtains thick leaching
Cream I is stored in clean, dry container, and labelling is spare,
4) surplus Paris polyphylla, the water measured with 10 times, 3 hours of each refluxing extraction extract 3 times；Merge the aqueous extract of Paris polyphylla, filter
It crosses, is concentrated under reduced pressure into thick medicinal extract, obtains thick medicinal extract II, set in clean, dry container, labelling is spare,
5) above-mentioned medicinal material dry powder II and thick medicinal extract I and thick medicinal extract II are sufficiently mixed uniformly, set in vacuum desiccator and dries, 60 DEG C
Under be dried under reduced pressure 6 hours to dry, crush, sieve with 100 mesh sieve, obtain medicinal material dry powder III, set in the container of clean dried, label, it is standby
With,
6) above-mentioned medicinal material dry powder I and medicinal material dry powder III are sufficiently mixed uniformly to get total raw material dry powder,
7) further according to total raw material dry powder quantity, the preparation of respective numbers is made.
7. Chinese medicine composition according to claim 1 or 2, which is characterized in that be prepared by the raw material of following proportioning；
Preparation process：
1) it, weighs after Paris polyphylla 100g is dried 3 hours in vacuum drying chamber at 80 DEG C and crushes in prescription ratio, sieve with 100 mesh sieve, medicine
Material dry powder I, is placed in the container of clean dried, labelling, spare,
2), by the short top top of the ginger peel of recipe quantity, drape over one's shoulders numb grass, tuniclike psammosilene root, Chinese yam, 5 taste medicinal material of Stephania epigaea, together in vacuum drying chamber
In be dried under reduced pressure 3 hours at 100 DEG C after crush, sieve with 100 mesh sieve, medicinal material dry powder II is placed in the container of clean dried, labeling
Label, it is spare,
3) it, by the wild aconite root of prescription proportional quantities, Bleeding-Stopping Bolus, rhizoma polygoni paleacei, Semen Strychni (processed), the sub- gomi herbs of datura alba Nees, crushes
Afterwards, 70% alcohol reflux measured with 12 times extracts 3 times, every time 1 hour；70% ethanol extract is taken, filters, is concentrated under reduced pressure into
Thick medicinal extract obtains thick medicinal extract I, is stored in clean, dry container, and labelling is spare,
4) Paris polyphylla 140g, is weighed in prescription ratio, the water measured with 10 times, 3 hours of each refluxing extraction extract 3 times；Merge weight
The aqueous extract in building, filtration are concentrated under reduced pressure into thick medicinal extract, obtain thick medicinal extract II, set in clean, dry container, and labelling is standby
With,
5), above-mentioned medicinal material dry powder II and thick medicinal extract I and thick medicinal extract II are sufficiently mixed uniformly, sets in vacuum desiccator and dries, 60
It is dried under reduced pressure 6 hours at DEG C to doing, crushes, sieves with 100 mesh sieve, obtain medicinal material dry powder III, set in the container of clean dried, label,
It is spare,
6), above-mentioned medicinal material dry powder I and medicinal material dry powder III are sufficiently mixed uniformly to get total raw material dry powder,
Total raw material medicinal powder is placed in grinding container, appropriate amount of auxiliary materials microcrystalline cellulose is added later, ground and mixed 10-30 minutes is extremely
Until uniformly, the medicinal powder of mixing is distributed into 1000 No. 1 capsules.
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Non-Patent Citations (2)
| Title |
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| "痛血康胶囊治疗术后疼痛30例临床小结";侯宝兴等;《海峡药学》;20001231;第12卷(第4期);第66-67页，尤其是第66页左栏第1段和右栏最后1段，第67页左栏第1段 * |
| "痛血康胶囊质量控制的研究";章勉;《中国优秀硕士学位论文全文数据库 医药卫生科技辑》;20141015(第10期);第E057-141页，尤其是摘要第1段和第4段 * |
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