CN1593517A - Method for preparing a gynecopathy treating medicine - Google Patents

Abstract

The invention discloses a method for preparing a gynecopathy treating medicine by using pilose asiabell root, prickly, mahonia stem, root of Fructus Rosae Laevigatae, Moghania philippinensis, spatholobus stem, Chinese angelica root, green chiretta through the steps of, separating chosen green chiretta and Chinese angelica root, extracting by ethanol heated backflow method or ethanol diacolation, filtering and reclaiming ethanol, concentrating the filtrate into concrete with specific gravity of 1.08/80 deg. C for later use, subjecting the selected codonopsis pilosula, asiabell root, prickly, root of Fructus Rosae Laevigatae, Moghania philippinensis and spatholobus stem to water boiling extraction, merging with the obtained green chiretta decoction dregs, water boiling for a second extraction, merging the two filtrates, concentrating into concrete with specific gravity of 1.08/80 deg. C for later use, merging the three types of clear greases, bed blending, spray drying, palletizing, obtaining granule form or capsule form medicine through loading procedure, obtaining tablet form medicine through pelleting, after full mixing of the concrete, obtaining soft capsule form medicine through direct loading, or preparing syrup by filling solution.

Description

A kind of process for preparing medicine for the treatment of gynaecopathia

Technical field

The present invention relates to a kind of process for preparing medicine for the treatment of gynaecopathia, referring in particular to Chinese crude drug Fructus Zanthoxyli Dissiti, Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, Caulis Spatholobi, Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis is the manufacture method of gynecological's Chinese patent medicine of raw material.

Background technology

The patent No. is a kind of claimed manufacturing technique method that ZL98112696.0's " a kind of process for preparing medicine for the treatment of gynaecopathia " " FUKE QIANJIN PIAN " that to be the clear people in this Shen produce for company at that time on October 21st, 1998 proposes.In above-mentioned disclosed production method, its protection fundamentally mainly embodies a concentrated reflection of both ways: the first is ground into fine powder more than 100 orders with Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis three flavor Chinese crude drugs in pulverizer, leaves and takes 93.3% standby; It two is that Fructus Zanthoxyli Dissiti, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis and the Caulis Spatholobi Chinese medicine of the five flavours that will choose is placed in the extraction pot together, adds hot water and extracts twice by the method for extracting once in per 2 hours, crosses leaching liquid; Proportion is 1.08/80 ℃ extractum in then extracting solution being concentrated in the triple effect concentrator.

Then, my company has proposed medicine---the FUKE QIANJIN PIAN with the treatment gynaecopathia again, production method with two kinds of capsules of identical prescription, and submitted the patent application (patent No. and application number are respectively: 99115682.x, 99115683.8) of two kinds of capsule manufacture methods on the 7th in December in 1999 to State Patent Office.

In the manufacture method of these two kinds of capsules, its main characteristics is: Radix Angelicae Sinensis and this two flavors Chinese medicine of Herba Andrographis are extracted both effective ingredient with alcohol heating reflux method or alcohol percolation method together or respectively, to reach the content that both reduces fecula material in the patent medicine, improve the amount of effective ingredient again, thereby make the patient both reduce dosage, can keep good efficacy again.

Though production practices for many years show above-mentioned kinds of processes method and are successfully effective in the production of instructing " FUKE QIANJIN PIAN ".But along with deep development to pharmaceutics of Chinese drugs and Chinese crude drug pharmacological research, especially in today of other subject technology develop rapidly, be based upon the production method of " FUKE QIANJIN PIAN " series of products on traditional Chinese patent medicine manufacturing technique method, the demand of incompatibility development of the situation.Therefore, how to guarantee under the product quality prerequisite, further reduce production costs, medicament curative effect enhancement, the preparation method of the medicine of more effective, more economical treatment gynaecopathia is provided for society and patient, from production technology, innovate, tap the latent power, become the producer of this product of production and scientific research personnel's a main direction.

Technology contents

Purpose of the present invention: be intended on the basis of forefathers to " FUKE QIANJIN PIAN " series of products and technical study, under the prerequisite that does not change its basic prescription compatibility, a kind of more scientific and rational process for preparing medicine that can treat gynaecopathia is proposed, wish that it can not only continue to keep good drug effect, also can further improve simultaneously the utilization rate of Chinese material medicine resource, thereby bring better economic benefit and social benefit for manufacturer.

The preparation method of the medicine of this treatment gynaecopathia, it is made by Radix Codonopsis, Fructus Zanthoxyli Dissiti, Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, Caulis Spatholobi, Radix Angelicae Sinensis, Herba Andrographis, it is characterized in that preparing as follows:

A, with the Herba Andrographis chosen with alcohol heat reflux method or ethanol percolate extraction, filter, reclaim ethanol, and filtrate is condensed into proportion is 1.08/80 ℃ standby clear paste, medicinal residues are standby;

B, with the Radix Angelicae Sinensis chosen with alcohol heat reflux method or ethanol percolate extraction, filter, reclaim ethanol, and filtrate is condensed into proportion is 1.08/80 ℃ standby extractum;

C, with the Caulis Mahoniae of choosing, Fructus Zanthoxyli Dissiti, very heavy group, Radix Rosae Laevigatae, Caulis Spatholobi, Radix Codonopsis Six-element medical material place extractor in the lump, add water and extract twice by the method that decocting in water extracts after 2 hours once, filtration is taken off slag and is got filtrate, and with this filtering residue and A operation gained Herba Andrographis medicinal residues and the extraction again after 2 hours of B operation gained Radix Angelicae Sinensis medicinal residues merging decocting in water, filtration is taken off slag and is got filtrate, twice gained filter rear filtrate is merged, and to be condensed into proportion is 1.08/80 ℃ standby extractum;

D, merging A, B, three kinds of clear paste of C, mixing, spray drying is granulated, and makes granule or capsule through the fill operation; Make tablet through sheeting process, sugar coating or film-coat.

In addition, the extractum that merging A, B, C three technologies are obtained after fully mixing, is made soft capsule through the fill operation; Or mix sugary soln, make the syrup of treatment gynaecopathia.

A kind of preparation method for the treatment of medicine for gynecopathy according to above technical scheme proposition, obtained the FUKE QIANJIN JIAONANG manufacture method of patent of invention compares with our company, be the former powder of getting is gone into the Radix Codonopsis of usefulness and changed decocting in water into and be extracted into usefulness, and with Radix Angelicae Sinensis and Herba Andrographis by being ground into starch, change into alcohol reflux or percolation and extracting, obtain extractum; In addition, again the medicinal residues after above-mentioned two PROCESS FOR TREATMENT are carried out once more decocting in water and extract, not only reduce starch amount in the former processing technology, the patient is reduced take dose; And reduced the working environment that pulverizing process causes and polluted; Simultaneously, because Radix Codonopsis and Radix Angelicae Sinensis, Herba Andrographis are changed into the decocting in water extraction and use alcohol extraction, Radix Codonopsis and Radix Angelicae Sinensis, the effective medicinal ingredient of Herba Andrographis are fully used, thereby provide technical support for improving drug effect and herb resource utilization rate.

The specific embodiment

Improve medicine (FUKE QIANJIN PIAN) preparation method of later treatment gynaecopathia according to this innovation of technique scheme proposition, its prescription is still continued to use the prescription compatibility of ZL98112696.0 patent, and promptly this medicine-FUKE QIANJIN PIAN is still by respectively being Radix Angelicae Sinensis, Radix Codonopsis, Herba Andrographis, the Fructus Zanthoxyli Dissiti of 9 weight portions and respectively being Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, the common prescription of Caulis Spatholobi eight flavor Chinese crude drugs of 16 weight portions.Concrete preparation method is as follows:

A, with the Herba Andrographis chosen with alcohol heat reflux method or ethanol percolate extraction, filter, reclaim ethanol, and filtrate is condensed into proportion is 1.08/80 ℃ standby clear paste, medicinal residues are standby.

B, with the Radix Angelicae Sinensis chosen with alcohol heat reflux method or ethanol percolate extraction, filter, reclaim ethanol, and filtrate is condensed into proportion is 1.08/80 ℃ standby extractum.

C, with the Caulis Mahoniae of choosing, Fructus Zanthoxyli Dissiti, very heavy group, Radix Rosae Laevigatae, Caulis Spatholobi, Radix Codonopsis Six-element medical material place extractor in the lump, add water and extract twice by the method that decocting in water extracts after 2 hours once, filtration is taken off slag and is got filtrate, and with this filtering residue and A operation gained Herba Andrographis medicinal residues and the extraction again after 2 hours of B operation gained Radix Angelicae Sinensis medicinal residues merging decocting in water, filtration is taken off slag and is got filtrate, twice gained filter rear filtrate is merged, and to be condensed into proportion is 1.08/80 ℃ standby extractum.

D, merging A, B, three kinds of clear paste of C, mixing, spray drying is granulated, and makes granule or capsule through the fill operation; Make tablet through sheeting process, sugar coating or film-coat.

In addition, the extractum that merging A, B, C three technologies are obtained after fully mixing, is made soft capsule through the fill operation; Or mix sugary soln, make the syrup of treatment gynaecopathia.

Why research worker of the present invention proposes: Radix Codonopsis is carried out decocting in water with Fructus Zanthoxyli Dissiti, Caulis Mahoniae, this five tastes medical material of Radix Flemingiae Philippinensis and Caulis Spatholobi extract, its reason has three:

One adopts methods such as water extraction, solvent extraction that Radix Codonopsis is carried out chemical analysis and studies show that Radix Codonopsis mainly contains polysaccharide according to relevant scholar, multiple tangshenoside, base-β-D glycoside, α-D-fructose ethanol glycoside etc. just; Sterols composition such as α-Bo sterol, stigmasterol etc., its main pharmacodynamics material is water-soluble components, extract and can the main pharmacodynamics composition of Radix Codonopsis be extracted comparatively fully by decocting in water, changing Radix Codonopsis into decocting in water from original pulverizing extracts, this is more to give full play to better, the more effective processing method that Radix Codonopsis acts in this treatment medicine for gynecopathy of FUKE QIANJIN PIAN, also is the technical foundation of further this prescription being carried out evaluation of pharmacology prescription and clinical evaluation.

Its two, FUKE QIANJIN PIAN dose excessive (three times on the one, a time 6), it is the one of the main reasons that causes the FUKE QIANJIN PIAN dose excessive that Radix Codonopsis is pulverized with starch, can reduce the starch amount after changing decocting in water into, and dose is reduced.

Its three, at the pulverization process of existing FUKE QIANJIN PIAN production technology to Radix Codonopsis, existing Radix Codonopsis grinding processing method must be wanted the drying operation with Radix Codonopsis earlier, changes decocting in water into and can shorten processing link later on, reduce production costs; And out-of-date methods also have a defective in processing is pulverized, and dust is too big in the crushing process, and is unfavorable to environmental conservation, and after changing decocting in water into and extracting, working environment are improved.

In addition, in the technical scheme of invention, why propose Radix Angelicae Sinensis, Herba Andrographis are changed into alcohol heating reflux or percolation extraction by starch, mainly be from reducing dose and improving the bioavailability aspect and consider, and again with residue and the decocting in water extraction once more of other medicinal residues, mainly be from how extracting better and the closely related consideration of the medicinal ingredient that obtains them, make the water-soluble components extraction of Radix Angelicae Sinensis, Herba Andrographis more abundant, give full play to the characteristic of the finished product crude drug that makes.

For the be used as medicine change of processing method of Herba Andrographis, mainly due to handling Herba Andrographis with pulverizing the method for being used as medicine, not only can produce by leaf pulverizing after the Herba Andrographis drying and cause a large amount of dust, and the effective medicinal ingredient in this dust that flies upward---andrographolide also runs off thereupon, and shows through our experiment: the content of the andrographolide of one of main medicinal ingredient is apparently higher than Herba Andrographis branch portion in the Folium Andrographis; Therefore, after Herba Andrographis being used instead alcohol heat reflux (or percolation) extraction, can not only obviously improve the production and processing environment, also can avoid effective ingredient loss in its medicine, help strengthening drug effect with the present invention.

Claims (2)

1, a kind of process for preparing medicine for the treatment of gynaecopathia, it is made by Radix Codonopsis, Fructus Zanthoxyli Dissiti, Caulis Mahoniae, Radix Rosae Laevigatae, Radix Flemingiae Philippinensis, Caulis Spatholobi, Radix Angelicae Sinensis, Herba Andrographis, it is characterized in that preparing as follows:

A, the Herba Andrographis chosen filter with alcohol heat reflux method or ethanol percolate extraction, reclaim ethanol, and filtrate is condensed into proportion is 1.08/80 ℃ standby clear paste, and medicinal residues are standby;

B, with the Radix Angelicae Sinensis chosen with alcohol heat reflux method or ethanol percolate extraction, filter, reclaim ethanol, and filtrate is condensed into proportion is 1.08/80 ℃ standby extractum;

C, with the Caulis Mahoniae of choosing, Fructus Zanthoxyli Dissiti, very heavy group, Radix Rosae Laevigatae, Caulis Spatholobi, Radix Codonopsis Six-element medical material place extractor in the lump, add water and extract twice by the method that decocting in water extracts after 2 hours once, filtration is taken off slag and is got filtrate, and with this filtering residue and A operation gained Herba Andrographis medicinal residues and the extraction again after 2 hours of B operation gained Radix Angelicae Sinensis medicinal residues merging decocting in water, filtration is taken off slag and is got filtrate, twice gained filter rear filtrate is merged, and to be condensed into proportion is 1.08/80 ℃ standby extractum;

D, merging A, B, three kinds of clear paste of C, mixing, spray drying is granulated, and makes granule or capsule through the fill operation; Make tablet through sheeting process, sugar coating or film-coat.

2, a kind of process for preparing medicine for the treatment of gynaecopathia as claimed in claim 1 is characterized in that: the extractum that merging A, B, C three technologies are obtained, after fully mixing, make soft capsule through the fill operation; Or mix sugary soln, make the syrup of treatment gynaecopathia.