CN1850132A - Herba thesii granules and preparing method therefor - Google Patents
Herba thesii granules and preparing method therefor Download PDFInfo
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Abstract
The present invention relates to a thesium Chinese granule preparation and its preparation method. It includes main raw material thesium Chinese and auxiliary material according to the mixing ratio of 1:1-1:2. Its auxiliary material includes excipient dextrin, stevioside or cane sugar as sweetener, and ethyl alcohol as lubricating agent and adhesive.
Description
Technical field
The present invention relates to novel form of a kind of Chinese patent medicine and preparation method thereof, be specifically related to a kind of Herba Thesii granule novel form and preparation method thereof.
Background technology
In recent years investigation shows that only community acquired pneumonia promptly had 400 ten thousand examples in 1 year in the U.S., and treatment respiratory tract infection prescription is anti-infectives more than 75%.Because the drug resistance phenomenon of the caused respiratory pathogen of medication is very outstanding, Macrolide and the 1st generation cephalo-type drug resistance become serious, as being 14.1% in the early 1990s to the drug-fast streptococcus pneumoniae of penicillin, the later stage nineties is up to 34.7%, and 13.5% is the height drug resistance; To penicillin drug resistance (MIC＞2 μ g/mL), and to the drug-fast streptococcus pneumoniae of cefotaxime up to 81.9%.Thereby the medicine of developing new treatment respiratory system infection is very important with regard to what show, and modern pharmacological research shows that Herba Thesii has the excellent antibiotic effect, and Chinese medicine is difficult for producing drug resistance.Mainly contain the Herba Thesii capsule at present, concrete this medicine of proof that uses all has curative effect preferably to treating acute and chronic pharyngolaryngitis, tracheitis, rhinitis, cold, fever and pneumonia.But capsule formulation is difficult for taking, and especially be not easy to child patient and take, and after capsule dissolved in the stomach, it was too high to be easy to generate local concentration, thereby zest strengthens, and takes so also be not easy to serious patients with gastric disease.
Summary of the invention
The present invention is directed to the deficiency of existing Herba Thesii capsule formulation, developed easily and taken, especially be easy to child patient and take, and the bland under one's belt hundred stamen granule novel forms of medicine.
The present invention is achieved by the following technical solutions:
A kind of hundred stamen granules, include major ingredient Herba Thesii and adjuvant, adjuvant can be selected one or both or the two or more mixture in dextrin, Icing Sugar, mannitol, xylitol, SHUANGQITANG, steviosin, protein sugar, high fructose, cyclamate, ethanol, polyvinylpyrrolidone and the Polyethylene Glycol for use.
A kind of hundred stamen granules, in its described adjuvant, excipient is a dextrin, correctives is steviosin or sucrose.
The particulate preparation method of a kind of hundred stamens, hundred stamen granules have the preparation method of sugared type may further comprise the steps:
(1) according to medicinal substances extract: adjuvant is 1: 3～1: 6, gets Herba Thesii 1200g and decocts with water secondary, adds 8-12 times of water gaging for the first time, decocts 2 hours, adds 8-12 times of water gaging for the second time, decocts 1.5 hours;
(2) decocting liquid is filtered, merging filtrate, being evaporated to relative density is 1.22～1.24 (80 ℃), puts cold;
(3) add 60%-90% ethanol as wetting agent and binding agent, stir evenly; Add equivalent ethanol again, stir evenly;
(4) leave standstill 12 hours after, the leaching supernatant reclaims ethanol, being evaporated to relative density is the thick paste of 1.35～1.39 (80 ℃);
(5) it is an amount of to get dextrin in addition, with the thick paste mixing, adds sucrose, granulates, and drying is made, promptly.
The particulate preparation method of a kind of hundred stamens, the preparation method of hundred stamen granule Sugarless types may further comprise the steps:
(1) according to medicinal substances extract: adjuvant is 1: 1～1: 3, gets Herba Thesii 2400g and decocts with water secondary, adds 8-12 times of water gaging for the first time, decocts 2 hours, adds 8-12 times of water gaging for the second time, decocts 1.5 hours;
(2) decocting liquid is filtered, merging filtrate, being evaporated to relative density is 1.22～1.24 (80 ℃), puts cold; (3) add 60%-90% ethanol as wetting agent and binding agent, stir evenly; Add equivalent ethanol again, stir evenly;
(4) leave standstill 12 hours after, the leaching supernatant reclaims ethanol, being evaporated to relative density is the thick paste of 1.35～1.39 (80 ℃);
(5) it is an amount of to get dextrin in addition, with the thick paste mixing, adds steviosin, granulates, and drying is made, promptly.
The particulate preparation method of a kind of hundred stamens, it is described gets Herba Thesii and decocts with water secondary, adds 12 times of water gagings for the first time, soaks after 2 hours, adds 10 times of water gagings the second time.
Add doubling dose 75% ethanol in the particulate preparation method of a kind of hundred stamens, its described step (3), stir evenly.
The particulate preparation method of a kind of hundred stamens also can add one or both or two or more mixture in mannitol, xylitol, SHUANGQITANG, protein sugar, high fructose or the cyclamate as correctives in its described step (5).
The particulate preparation method of a kind of hundred stamens can add one or both or two or more mixture in polyvinylpyrrolidone and the Polyethylene Glycol as wetting agent and binding agent in its described step (3).
The particulate preparation method of a kind of hundred stamens, its described medicinal substances extract: adjuvant is 1: 4～1: 5.
The particulate preparation method of a kind of hundred stamens, its described medicinal substances extract: adjuvant the best is 1: 1～1: 2.
Hundred stamen preparations have three kinds of preparations such as BAIRUI PIAN, BAIRUI JIAONANG and BAIRUI HANPIAN in the market, and the present invention is a granule with the BAIRUI JIAONANG dosage changing form on the basis of former prescription.More behind the dosage changing form, hundred stamen granules can guarantee that not only original drug effect is constant, and because granule can directly be taken after mixing it with water, need not disintegrate can directly absorb, and therefore can promote the medicine quick acting, improve medicine soak time in vivo, improve bioavailability.Disease Modern Nursing such as cold, fever are thought should drink boiled water more, and granule takes after mixing it with hot water, meets the nursing of disease more, thereby promotes the quick rehabilitation of disease; Added correctives in the granule and can cover the bitterness of medicine discomfort, improved the compliance of people, enlarged the use crowd of medicine medicine.Hundred stamen granules are taken easily, and for the patient of different medications custom provides alternative dosage form, in addition, the present invention has prepared two kinds of sugared type and Sugarless types by adding different adjuvants, can further satisfy diabetics and take.
Acute and chronic pharyngolaryngitis, tracheitis, rhinitis, cold, fever, diseases such as pneumonia are for respiratory tract infection belongs to traditional Chinese medical science cough, sore throat etc.According to modern pharmacological research, Herba Thesii has significant antiinflammatory, analgesic, analgesia and antibacterial action.Can suppress the granuloma hypertrophy; Suppress Ovum Gallus domesticus album and cause rat paw edema; The growth and breeding that can suppress streptococcus pneumoniae, bacillus pyocyaneus, staphylococcus aureus and alpha streptococcus.Clinical practice confirms that various acute inflammation such as acute tonsillitis, acute pharyngolaryngitis, chronic pharyngolaryngitis acute attack and upper respiratory tract infection are had better curative effect, and has no side effect.The experimentation experiment of BAIRUI PIAN pharmacological action shows: BAIRUI PIAN all has significant inhibition growth effect to staphylococcus aureus, dysentery bacterium, Bacillus typhi etc.; Can obviously suppress auricle edema effect due to the dimethylbenzene, significantly suppress rat cotton balls granuloma, but do not see obvious dose-effect dependency between each dosage group.BAIRUI PIAN can improve the phenol red excretion of mice trachea, is dose-effect trend; The large, medium and small dosage group of BAIRUI PIAN draws to cough to the mice strong aqua ammonia all significant antitussive action, can significantly reduce mice per minute cough number of times and shorten the incubation period of coughing.BAIRUI PIAN is to the effect of being significantly improved of mouse thymus coefficient; Heavy dose of group is significantly increased effect to mice IgG content.Under above-mentioned experiment instruction, the present invention adopts the Herba Thesii single medicinal material through extracting processing, develops into granule---and " hundred stamen granules " is to supply clinical needs.
One, treats various acute inflammations
Treat kind surplus the various acute inflammation meters 30, example surplus in the of 200, effective percentage is on average about 90%.Acute mastitis 44 examples wherein, 31 examples of fully recovering, produce effects 9 examples, 2 examples that take a turn for the better, invalid 2 examples, average course of treatment 4 days, effective percentage 95.5%; Lobar pneumonia 40 examples, 30 examples of fully recovering, produce effects 2 examples, 1 example that takes a turn for the better, invalid 7 examples, average course of treatment 12 days, effective percentage 82.5%.For the treatment acute suppurative otitis media, there is clinical report to show better curative effect, and has no side effect.
Two, treat various infection
Treatment respiratory system infection 18 examples, acute upper respiratory tract infection 6 examples wherein, acute bronchitis 6 examples, pneumonia 2 examples, acute episode of chronic bronchitis 4 examples do not add Western medicine and antibiotics without exception.With every day 3 times, each 4,7 days is a course of treatment.The result is produce effects 6 examples, accounts for 33.3%; Effective 11 examples account for 61.1%; Invalid 1 example accounts for 5.6%; Total effective rate reaches 94.4%.The Herba Thesii granule is good to the cerebral trauma infectious effect, and the back prevention infection that is used to perform the operation also produces effect.
Three, Study on Preparation (optimal process test method, data conclusion)
(1), dosage form selection
" hundred stamen granules " is " BAIRUI JIAONANG " dosage changing form, the present invention presses the capsule method for making, utilize water extract-alcohol precipitation to extract the flavonoid glycoside and the aqueous soluble active constituent of this medicine in the prescription, make granule, both be beneficial to the reservation and the stability of formulation of effective ingredient, increased novel form again, satisfy clinical requirement, improve the quality of products simultaneously, guarantee drug safety, effective, made things convenient for the patient to take, and absorbed faster.
(2), the research of Herba Thesii decocting technology
Herba Thesii extraction and purifying process are compared with former dosage form, owing to primary standard is not indicated soak time, water absorption rate, added the water multiple, so it is studied.
1. the examination of water absorption rate
Take by weighing Herba Thesii medical material 1000 grams and soak to the saturating heart, filtration records water absorption rate and is about 205% (n=3).
2, the investigation of medicinal material extract amount of water
Report according to documents and materials, main effective ingredient is a flavonoid glycoside compound in the Herba Thesii, composition and dosage form requirement according to the prescription taste of Chinese medicine, we are the assay index with its main effective ingredient kaempferol, measure the extraction ratio of flavonoid in the extractum, select for use dried cream yield as performance assessment criteria simultaneously, carry out overall merit.
Get three parts of Herba Thesii medical materials, every part of 1000g adds the water of 8 times, 10 times, 12 times amounts respectively, soaked 2 hours, and decocted secondary, 2 hours for the first time, every secondary 1.5 hours, (by medical material water absorption rate 205%, adding the water of 2 times of amounts when adding water for the first time), filter, collecting decoction, being evaporated to relative density is 1.22～1.24 (80 ℃), put coldly, add doubling dose 75% ethanol, stir evenly, add equivalent ethanol again, stir evenly.After leaving standstill 12 hours, the leaching supernatant, decompression recycling ethanol also is settled to 1000ml.
2.1 the mensuration precision of dry extract yield is measured said extracted liquid 25ml, by " method under Chinese pharmacopoeia (appendix XA of version in the 2000) item is measured, promptly.
2.2 kaempferol assay
Root a tree name documents and materials, its main effective ingredient is a flavonoid glycoside compound, with reference to relevant document, adopts the content of one of the main effective ingredient of high effective liquid chromatography for measuring this product kaempferol.
1. chromatographic condition
Century SIL BDS C
18Chromatographic column 250 * 4.6mm (5 μ m), mobile phase: methanol: 0.5% phosphoric acid solution (62: 38)
2. the preparation of reference substance solution: it is an amount of to get the kaempferol reference substance, and accurate the title decides, and is mixed with the solution of every 40ug/ml, promptly gets reference substance solution
3. the preparation of sample test liquid: get the about 0.2g of Herba Thesii dry extract, the accurate title, decide, and adds 70% ethanol 30ml and make dissolving, add 25% hydrochloric acid 5ml water-bath again and refluxed 1 hour, put coldly, be settled to 50ml, shake up, use the 0.45um filtering with microporous membrane, promptly get need testing solution.
4. algoscopy: accurate each 10ul of above-mentioned solution that draws, inject chromatograph of liquid, measure, calculate kaempferol content.
2.3 result of the test
The different amount of water dry extract of table 1 yield
| The experiment number | Each amount of water | Dry extract yield % | Kaempferol content (%) |
| 1 | 8 times | 6.6 | 1.057 |
| 2 | 10 times | 7.5 | 1.034 |
| 3 | 12 times | 7.7 | 1.012 |
By result in the table as can be known, the water that at every turn adds 10 times, 12 times amounts is significantly better than adding 8 times of water gagings, and the water extraction dry extract yield of 12 times of amounts is a little more than 10 times of water gagings, but kaempferol content is lower slightly, and the two is very approaching, illustrates substantially and has carried.
Take all factors into consideration whole process flow and medical material water absorption rate (2.05ml/g), we are defined as Herba Thesii with extraction process and decoct with water secondary, add 12 times of water gagings for the first time, soak after 2 hours, decoct 2 hours, add 10 times of water gagings for the second time, decoct 1.5 hours.(pilot plant is: TQ-1T multipotency extraction pot, connection pharmaceutical machine factory in the Wuhan)
(3) separate remove impurity and concentrate
It mainly is the solid particle of removing in the liquid that the decocting extracting solution separates remove impurity, guarantees the quality of the pharmaceutical preparations, makes filter material with 200 order nylon cloths while hot through the test medicinal liquid, and filtrate through staticly settling, is drawn supernatant again, filters with plate basket pressure filter.Decompose for reducing effective ingredient as much as possible, it is 1.22～1.24 (80 ℃) that filtrate adopts the concentrating under reduced pressure method to be concentrated into relative density, puts coldly, adds doubling dose 75% ethanol, stirs evenly; Add equivalent ethanol again, contain alcohol amount this moment is 72.5%, stirs evenly, leave standstill 12 hours after, the leaching supernatant reclaims ethanol, being evaporated to relative density is the thick paste of 1.35～1.39 (80 ℃).After the precipitate with ethanol drying precipitate, press the preparation of test sample preparation method, inject chromatograph of liquid, the record peak area.As a result, can not detect kaempferol.(pilot plant is the WX-1000 external circulation evaporator:, Changzhou Meng Cheng drying equipment factory.Pressure=-0.06MPa, 75～80 ℃ of temperature)
(4) Study on Forming
Adopt wet granulation, can reduce process procedure, shorten manufacturing cycle, be easy to suitability for industrialized production.Method for making according to " hundred stamen granules ", every 1200g medical material is made the 1000g granule, because of the extractum relative density is 1.35～1.39 (80 ℃), than stiff, viscosity is big when preventing to granulate, sad sieve, and caking when dry, piebaldism, pellet hardness are big, bibulous phenomenon, it is the preparations shaping adjuvant that this technology is selected granule usual excipients Icing Sugar and dextrin for use, good moldability, and cheap, the finished particle good water solubility.Under the prerequisite that guarantees the quality of the pharmaceutical preparations, reduce supplementary product consumption as far as possible, to reduce cost, reduce dose, therefore, on the basis of primary standard [method for making], whether easily granulate and the finished particle moisture resistance is an index with preparation, adjuvant dextrin and Icing Sugar consumption screen during to pelletizing forming, repeat three times, the results are shown in Table 2.Simultaneously, whether be index to granule if luming when granulating, and the concentration of diluent ethanol is screened, and sees Table 3.Experiment repeats three times,
Table 2 dextrin Icing Sugar consumption screening test (n=3)
| The prescription number | 1 | 2 | 3 |
| Extractum (g) | 164 | 164 | 164 |
| Dextrin (g) | 900 | 200 | - |
| Icing Sugar (g) | - | 700 | 900 |
| Granulate | Difficult | Easily | Easier |
| The granule moisture resistance | Better | Better | Relatively poor |
The result shows, when with prescription 2, grain forming is better, yield rate is high.So we select prescription 2 for use is hundred stamen shaping particles adjuvants.
Table 3 concentration of alcohol screening test (n=3)
| Concentration of alcohol (%) | 60 | 70 | 80 | 90 |
| Granule | Caking | Better | Better | Frangible |
Above-mentioned test shows: when granulating with 70% following concentration of alcohol, the granule caking is difficult to sieve; When granulating with 80% above concentration of alcohol, though there is not caking, be easy to sieve, granule is frangible, and it is better to select for use 70%-80% ethanol to make the wetting agent granulating efficiency, and therefore, this process using prescription 3 is selected 75% alcohol granulation for use.
(5) particle drying
75～80 ℃ of temperature, dry 3～4 hours, the granule water content was about at 1.5～2.5% o'clock, is chilled to room temperature.
Pilot plant: FG-ZII hot air circulation drying oven, Changzhou shake the manufacturing of magnificent drying equipment company limited.
The examination of (six) hundred stamen granule hydroscopicities
The mensuration of critical relative humidity
With above-mentioned particle drying to constant weight, get about 4 grams, the accurate title, decide, place the weighing botle of constant weight, place the exsiccator of the supersaturated solution that fills 6 kinds of variable concentrations sulphuric acid or different salt respectively, open the weighing bottle cap, in 25 ℃ of constant incubators, keep after 48 hours, weigh, calculate hydroscopicity.
Medicated powder is at 25 ℃ hydroscopicity under the different relative humiditys of table 4
| Sulfuric acid concentration and supersaturated salt solution | Relative humidity/25 ℃ .% | Hydroscopicity % |
| 54％H 2SO 4 | 29.55 | 0.33 |
| 48％H 2SO 4 | 40.52 | 2.8 |
| 44％H 2SO 4 | 48.52 | 6.72 |
| NaBr | 57.70 | 9.44 |
| NaCl | 75.28 | 12.97 |
| KCl | 84.26 | 17.54 |
The specific embodiment
Embodiment 1
A kind of hundred stamen granules include major ingredient Herba Thesii and adjuvant dextrin, sucrose and ethanol.The particulate preparation method of hundred stamens prepares according to the following steps:
(1) according to medicinal substances extract: adjuvant is 1: 5, gets Herba Thesii 1200g and decocts with water secondary, adds 12 times of water gagings for the first time, soaks after 2 hours, decocts 2 hours, adds 10 times of water gagings for the second time, decocts 1.5 hours;
(2) decocting liquid is filtered, merging filtrate, being evaporated to relative density is 1.22～1.24 (80 ℃), puts cold;
(3) add 75% ethanol, stir evenly; Add equivalent ethanol again, stir evenly;
(4) leave standstill 12 hours after, the leaching supernatant reclaims ethanol, being evaporated to relative density is the thick paste of 1.35～1.39 (80 ℃);
(5) it is an amount of to get dextrin in addition, with the thick paste mixing, adds sucrose, granulates, and drying is made, and promptly gets hundred stamen granules of sugared type.
Embodiment 2
A kind of hundred stamen granules include major ingredient Herba Thesii and adjuvant dextrin, sucrose and ethanol.The particulate preparation method of hundred stamens prepares according to the following steps:
(1) according to medicinal substances extract: adjuvant is 1: 2, gets Herba Thesii 2400g and decocts with water secondary, adds 12 times of water gagings for the first time, soaks after 2 hours, decocts 2 hours, adds 10 times of water gagings for the second time, decocts 1.5 hours;
(2) decocting liquid is filtered, merging filtrate, being evaporated to relative density is 1.22～1.24 (80 ℃), puts cold;
(3) add 75% ethanol, stir evenly; Add equivalent ethanol again, stir evenly;
(4) leave standstill 12 hours after, the leaching supernatant reclaims ethanol, being evaporated to relative density is the thick paste of 1.35～1.39 (80 ℃);
(5) it is an amount of to get dextrin in addition, with the thick paste mixing, adds steviosin, granulates, and drying is made, and promptly gets hundred stamen granules of Sugarless type.
Embodiment 3
A kind of hundred stamen granules include major ingredient Herba Thesii and adjuvant dextrin, sucrose and ethanol.The particulate preparation method of hundred stamens prepares according to the following steps:
(1) according to medicinal substances extract: adjuvant is 1: 5, gets Herba Thesii 1200g and decocts with water secondary, adds 10 times of water gagings for the first time, soaks after 2 hours, decocts 2 hours, adds 8 times of water gagings for the second time, decocts 1.5 hours;
(2) decocting liquid is filtered, merging filtrate, being evaporated to relative density is 1.22～1.24 (80 ℃), puts cold;
(3) add 60% ethanol, stir evenly; Add equivalent ethanol again, stir evenly;
All the other are with embodiment 1.
Embodiment 4
A kind of hundred stamen granules include major ingredient Herba Thesii and adjuvant dextrin, sucrose and ethanol.The particulate preparation method of hundred stamens prepares according to the following steps:
(1) according to medicinal substances extract: adjuvant is 1: 5, gets Herba Thesii 1200g and decocts with water secondary, adds 8 times of water gagings for the first time, soaks after 2 hours, decocts 2 hours, adds 10 times of water gagings for the second time, decocts 1.5 hours;
(2) decocting liquid is filtered, merging filtrate, being evaporated to relative density is 1.22～1.24 (80 ℃), puts cold;
(3) add 90% ethanol, stir evenly; Add equivalent ethanol again, stir evenly;
All the other are with embodiment 1.
Embodiment 5
Correctives select for use mannitol all the other with embodiment 1.
Embodiment 6
Correctives select for use xylitol all the other with embodiment 1.
Embodiment 7
Correctives select for use SHUANGQITANG all the other with embodiment 1.
Embodiment 8
Correctives select for use protein sugar all the other with embodiment 1.
Embodiment 9
Wetting agent and binding agent select for use polyvinylpyrrolidone all the other with embodiment 1.
Embodiment 10
Wetting agent and binding agent select for use Polyethylene Glycol all the other with embodiment 1.
Claims (10)
1, a kind of hundred stamen granules, include major ingredient Herba Thesii and adjuvant, it is characterized in that adjuvant selects one or both or the two or more mixture in dextrin, Icing Sugar, mannitol, xylitol, SHUANGQITANG, steviosin, protein sugar, high fructose, cyclamate, ethanol, polyvinylpyrrolidone and the Polyethylene Glycol for use.
2, a kind of hundred stamen granules according to claim 1 is characterized in that in the described adjuvant that excipient is a dextrin, and correctives is steviosin or sucrose.
3, the particulate preparation method of a kind of hundred stamens according to claim 1 is characterized in that may further comprise the steps:
(1) according to medicinal substances extract: adjuvant is 1: 3～1: 6, gets Herba Thesii 1200g and decocts with water secondary, adds 8-12 times of water gaging for the first time, decocts 2 hours, adds 8-12 times of water gaging for the second time, decocts 1.5 hours;
(2) decocting liquid is filtered, merging filtrate, being evaporated to relative density is 1.22～1.24 (80 ℃), puts cold;
(3) add 60%-90% ethanol as wetting agent and binding agent, stir evenly; Add equivalent ethanol again, stir evenly;
(4) leave standstill 12 hours after, the leaching supernatant reclaims ethanol, being evaporated to relative density is the thick paste of 1.35～1.39 (80 ℃);
(5) it is an amount of to get dextrin in addition, with the thick paste mixing, adds sucrose, granulates, and drying is made, promptly.
4, the particulate preparation method of a kind of hundred stamens according to claim 1 is characterized in that may further comprise the steps:
(1) according to medicinal substances extract: adjuvant is 1: 1～1: 3, gets Herba Thesii 2400g and decocts with water secondary, adds 8-12 times of water gaging for the first time, decocts 2 hours, adds 8-12 times of water gaging for the second time, decocts 1.5 hours;
(2) decocting liquid is filtered, merging filtrate, being evaporated to relative density is 1.22～1.24 (80 ℃), puts cold;
(3) add 60%-90% ethanol as wetting agent and binding agent, stir evenly; Add equivalent ethanol again, stir evenly;
(4) leave standstill 12 hours after, the leaching supernatant reclaims ethanol, being evaporated to relative density is the thick paste of 1.35～1.39 (80 ℃);
(5) it is an amount of to get dextrin in addition, with the thick paste mixing, adds steviosin, granulates, and drying is made, promptly.
5, according to claim 3 or the particulate preparation method of 4 described a kind of hundred stamens, it is characterized in that describedly getting Herba Thesii and decocting with water secondary, add 12 times of water gagings for the first time, soaks after 2 hours, add 10 times of water gagings the second time.
6, according to claim 3 or the particulate preparation method of 4 described a kind of hundred stamens, it is characterized in that adding doubling dose 75% ethanol in the described step (3), stir evenly.
7,, it is characterized in that also can adding in the described step (5) one or both or two or more mixture in mannitol, xylitol, SHUANGQITANG, protein sugar, high fructose or the cyclamate as correctives according to claim 3 or the particulate preparation method of 4 described a kind of hundred stamens.
8,, it is characterized in that to add in the described step (3) one or both or two or more mixture in polyvinylpyrrolidone and the Polyethylene Glycol as wetting agent and binding agent according to claim 3 or the particulate preparation method of 4 described a kind of hundred stamens.
9, the particulate preparation method of a kind of hundred stamens according to claim 3, it is characterized in that described medicinal substances extract: adjuvant is 1: 4～1: 5.
10, the particulate preparation method of a kind of hundred stamens according to claim 4, it is characterized in that described medicinal substances extract: adjuvant is 1: 1～1: 2.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103585204A (en) * | 2013-10-25 | 2014-02-19 | 管悦琴 | Thesium granule with high stability and preparation method thereof |
| CN110755386A (en) * | 2019-11-01 | 2020-02-07 | 安徽九华华源药业有限公司 | Application of thesium Chinese granules in preparation of medicine for treating hyperpyrexia caused by pathogenic bacteria infection |
| CN115947770A (en) * | 2022-12-26 | 2023-04-11 | 安徽省森湶谷药业股份有限公司 | Novel thesine compound and application thereof |
-
2006
- 2006-02-27 CN CN 200610038548 patent/CN1850132A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103585204A (en) * | 2013-10-25 | 2014-02-19 | 管悦琴 | Thesium granule with high stability and preparation method thereof |
| CN103585204B (en) * | 2013-10-25 | 2015-06-03 | 管悦琴 | Thesium granule with high stability and preparation method thereof |
| CN110755386A (en) * | 2019-11-01 | 2020-02-07 | 安徽九华华源药业有限公司 | Application of thesium Chinese granules in preparation of medicine for treating hyperpyrexia caused by pathogenic bacteria infection |
| CN110755386B (en) * | 2019-11-01 | 2022-02-18 | 安徽九华华源药业有限公司 | Application of thesium Chinese granules in preparation of medicine for treating hyperpyrexia caused by pathogenic bacteria infection |
| CN115947770A (en) * | 2022-12-26 | 2023-04-11 | 安徽省森湶谷药业股份有限公司 | Novel thesine compound and application thereof |
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