CN115969909A - Traditional Chinese medicine composition for improving sub-health of sows, fermented traditional Chinese medicine preparation, and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for improving sub-health of sows, fermented traditional Chinese medicine preparation, and preparation method and application thereof Download PDFInfo
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Abstract
The invention belongs to the technical field of fermented traditional Chinese medicine preparations for livestock, and particularly relates to a traditional Chinese medicine composition for improving the sub-health of sows, a fermented traditional Chinese medicine preparation, and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-30 parts of silybum marianum, 20-30 parts of giant knotweed, 20-30 parts of water chestnut, 10-15 parts of honeysuckle stem, 5-10 parts of white peony root, 5-10 parts of gynostemma pentaphylla, 10-15 parts of liquorice, 1-5 parts of codonopsis pilosula, 5-10 parts of bighead atractylodes rhizome, 5-10 parts of Chinese angelica, 1-5 parts of salvia miltiorrhiza, 1-5 parts of astragalus membranaceus, 1-5 parts of eclipta, 1-5 parts of radix bupleuri, 1-5 parts of poria cocos, 1-5 parts of dried orange peel, 1-5 parts of fried hawthorn and 1-5 parts of organic yeast selenium. The traditional Chinese medicine composition and the fermented traditional Chinese medicine preparation can comprehensively improve the sub-health state of the sow and improve the health degree of the sow, so that the breeding rate of the replacement sow is improved, the two-fetus syndrome of the sow is remarkably reduced, the lachrymal edema of the multiparous sow is eliminated, the skin is reddish, the sub-health state of the sow is eliminated, the oestrus mating is recovered to be normal, and the elimination rate of the sow is reduced.
Description
Technical Field
The invention belongs to the technical field of fermented traditional Chinese medicine preparations for livestock, and particularly relates to a traditional Chinese medicine composition for improving the sub-health of sows, a fermented traditional Chinese medicine preparation, and a preparation method and application thereof.
Background
The sow is the core of the breeding of the pig farm, the disease resistance and the stress resistance of the piglets are closely related to the sow, the health state of the sow is directly related to the exertion of the production performance and influences the production benefit of the pig farm, and particularly, the high-intensity production rhythm is adopted by a large-scale and intensive breeding mode in the modern animal husbandry breeding, so that higher requirements are provided for the health level of the sow. However, the sows may be disturbed by internal and external environments during the growth process, and once the toxins cannot be removed in time in the pigs, the swinery will release sub-health signals, namely, the phenomena of lacrimation, old skin, vulvar swelling, no oestrus, mammary dysplasia, vaccine antibody level reduction and the like occur. Health care for the sub-health state of sows becomes the core of various pig farms, but the side effects of the sows, such as the reduction of physique and reproductive productivity, caused by traditional antibiotic health care are questioned by industrial people more and more. Therefore, there is a need to find a green and pollution-free drug that can replace antibiotics to improve the sub-health status of sows and improve the productivity of sows.
In recent years, the demand for replacing resistance and reducing resistance in the breeding industry is higher and higher, the traditional Chinese veterinary medicine has the advantages of obvious prevention and treatment effect, relatively small toxic and side effect on livestock and poultry, no harmful residue in animal food and difficult generation of drug resistance, and the development of traditional Chinese veterinary medicine products and feed additives increasingly attracts people's attention nowadays when the food safety problem is sensitive. The application of the traditional Chinese veterinary medicine at present meets the objective requirements of livestock breeding, reflects the viewpoint of 'prevention before disease' in the traditional Chinese medicine prevention and treatment system, and enables the traditional Chinese veterinary medicine to participate in the prevention, stress resistance and antibiosis of animal epidemic diseases, so that the non-specific immunity of an animal body is fully regulated, the physiological function of the body is coordinated, and the disease prevention capability of the body is improved.
Fermentation technology has a history of thousands of years in China, but the traditional Chinese medicines prepared by fermentation are not many, the reason of the fermentation is greatly related to the screening and culture of microorganism varieties and the types of traditional Chinese medicines suitable for fermentation, the fermentation technology efficiency of the traditional Chinese medicines is low, and the requirement of industrial production is difficult to meet. In recent years, with the development of microecology, modern bioengineering technology is increasingly applied to the field of traditional Chinese medicine, especially fermentation technology. The traditional Chinese medicine can improve the performance of the medicine after fermentation, generate new medicine effect and provide basis for the development of new medicine sources.
In view of the above, the inventor of the invention combines the fermentation technology with the technical field of veterinary herbal medicine preparations, and develops a traditional Chinese medicine composition and a fermented traditional Chinese medicine preparation capable of improving the sub-health state of sows.
Disclosure of Invention
In order to solve the technical problems, the invention provides a traditional Chinese medicine composition for improving the sub-health of sows, a fermented traditional Chinese medicine preparation, and a preparation method and application thereof.
Specifically, the invention is realized by the following technical schemes:
in a first aspect, the invention provides a traditional Chinese medicine composition for improving the sub-health of sows, which is prepared from the following raw materials in parts by weight: 20-30 parts of silybum marianum, 20-30 parts of giant knotweed, 20-30 parts of water chestnut, 10-15 parts of honeysuckle stem, 5-10 parts of white peony root, 5-10 parts of gynostemma pentaphylla, 10-15 parts of liquorice, 1-5 parts of codonopsis pilosula, 5-10 parts of bighead atractylodes rhizome, 5-10 parts of Chinese angelica, 1-5 parts of salvia miltiorrhiza, 1-5 parts of astragalus membranaceus, 1-5 parts of eclipta, 1-5 parts of radix bupleuri, 1-5 parts of poria cocos, 1-5 parts of dried orange peel, 1-5 parts of fried hawthorn and 1-5 parts of organic yeast selenium.
As an optional mode, in the traditional Chinese medicine composition, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25-30 parts of silybum marianum, 25-30 parts of polygonum cuspidatum, 20-30 parts of water chestnut, 10-15 parts of honeysuckle stem, 5-10 parts of white peony root, 5-10 parts of gynostemma pentaphylla, 10-15 parts of liquorice, 3-5 parts of codonopsis pilosula, 5-8 parts of bighead atractylodes rhizome, 5-10 parts of angelica, 1-5 parts of salvia miltiorrhiza, 2-5 parts of astragalus membranaceus, 2-5 parts of eclipta, 3-5 parts of radix bupleuri, 3-5 parts of poria cocos, 3-5 parts of dried orange peel, 3-5 parts of fried hawthorn and 2-5 parts of organic yeast selenium.
Preferably, in the above traditional Chinese medicine composition, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 parts of silybum marianum, 30 parts of giant knotweed rhizome, 20 parts of water chestnut, 10 parts of honeysuckle stem, 10 parts of white paeony root, 5 parts of gynostemma pentaphylla, 15 parts of liquorice, 3 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 5 parts of Chinese angelica, 1 part of salvia miltiorrhiza, 2 parts of astragalus mongholicus, 2 parts of eclipta, 5 parts of radix bupleuri, 5 parts of poria cocos, 5 parts of dried orange peel, 3 parts of fried hawthorn and 2 parts of organic yeast selenium.
In addition, preferably, in the above traditional Chinese medicine composition, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25 parts of silybum marianum, 30 parts of giant knotweed rhizome, 30 parts of water chestnut, 15 parts of honeysuckle stem, 5 parts of white paeony root, 10 parts of gynostemma pentaphylla, 10 parts of liquorice, 5 parts of codonopsis pilosula, 8 parts of bighead atractylodes rhizome, 10 parts of Chinese angelica, 5 parts of salvia miltiorrhiza, 5 parts of astragalus mongholicus, 5 parts of eclipta, 3 parts of radix bupleuri, 3 parts of poria cocos, 3 parts of dried orange peel, 5 parts of fried hawthorn and 5 parts of organic yeast selenium.
In a second aspect, the present invention provides a preparation method of the traditional Chinese medicine composition of the first aspect, wherein the preparation method comprises the following steps:
(1) Weighing raw materials in each weight ratio, mixing the raw materials except the raw materials dried by the organic yeast, and crushing;
(2) Adding 8-10 times of water into the raw material powder except organic selenium yeast, extracting at 50-60 deg.C for 2-3 hr, and transferring into fermentation tank;
(3) Adding white sugar 0.5-1 times of the total weight of the above materials except organic yeast selenium, stirring, cooling to 35 deg.C, fermenting for 5-7 days, and filtering to obtain fermentation liquid;
(4) Drying the fermentation broth;
(5) And (4) adding organic selenium yeast into the dried material obtained in the step (4), and mixing for 20-30 minutes to obtain the selenium-enriched dried material.
Optionally, in the above preparation method, in step (3), 0.05% to 0.1% of the total weight of the raw materials of the fermentation strain is added for fermentation, the filtration is 200 mesh filtration cloth filtration, and in step (4), the drying method is vacuum freeze drying, spray drying or vacuum drying.
Alternatively, in the above preparation method, in the step (3), the fermentation bacteria species is selected from one or more of: yeast, lactic acid bacteria, bacillus or enzyme.
Preferably, the fermentation strain is yeast.
In a third aspect, the invention provides a fermented traditional Chinese medicine preparation for improving the sub-health of sows, which comprises the traditional Chinese medicine composition in the first aspect, or the traditional Chinese medicine composition prepared by adopting the preparation method in the second aspect.
In a fourth aspect, the present invention provides the use of the Chinese medicinal composition of the first aspect or the fermented Chinese medicinal preparation of the second aspect in the preparation of a medicament for improving the sub-health of sows.
As an optional mode, in the above uses, the uses are to improve the breeding rate of replacement gilts, reduce the two-fetus syndrome of the sows, eliminate lacrimation bags of multiparous sows, restore reddish skin, eliminate the sub-health state of the sows, restore the normal oestrus hybridization of the sows and reduce the elimination rate of the sows.
In a fifth aspect, the present invention provides the use of the Chinese medicinal composition of the first aspect or the fermented Chinese medicinal preparation of the second aspect in preparing a feed for improving the sub-health of sows.
Optionally, in the above application, the Chinese medicinal composition or the fermented Chinese medicinal preparation is added to the feed in a weight percentage of 0.05% to 0.5%.
Compared with the prior art, the invention has the following beneficial effects:
(1) The traditional Chinese medicine composition and the fermented traditional Chinese medicine preparation can comprehensively improve the sub-health state of the sow and improve the health degree of the sow, so that the breeding rate of the replacement sow is improved, the two-fetus syndrome of the sow is remarkably reduced, the lachrymal edema of the multiparous sow is eliminated, the skin is reddish, the sub-health state of the sow is eliminated, the oestrus mating is recovered to be normal, and the elimination rate of the sow is reduced.
(2) The traditional Chinese medicine composition and the raw materials selected in the fermented traditional Chinese medicine are common raw materials in the field of traditional Chinese veterinary medicines, so that the safety of the traditional Chinese medicine composition and the fermented traditional Chinese medicines can be fully guaranteed, namely the invention provides a green pollution-free veterinary medicine capable of replacing antibiotics.
Detailed Description
The traditional Chinese medicine composition disclosed by the invention combines multiple medicines, and has the effects of clearing away heat and toxic materials, protecting liver and benefiting gallbladder, soothing liver and regulating qi, dispelling wind and promoting diuresis, removing blood stasis and relieving pain, inducing diuresis for treating stranguria, relieving cough and reducing sputum, tonifying qi and invigorating spleen and the like.
The specific descriptions of the raw materials used in the traditional Chinese medicine composition and the fermented traditional Chinese medicine preparation thereof are as follows:
silybum marianum: is an annual or biennial herb belonging to the family Compositae. The slim fruit is bitter and cool in nature and taste, and has the effects of clearing heat and promoting diuresis, and soothing liver and gallbladder. Modern pharmacological studies prove that the silybum marianum has the effects of protecting the liver, reducing blood fat and resisting atheromatous plaque formation, has the protective effect on both cardiovascular system and cerebral ischemia, and also has the anti-platelet aggregation effect.
Giant knotweed rhizome: is a perennial herb of Polygonaceae, polygonum. The rhizome is used for medicine, and has slightly bitter and cold property. Giant knotweed rhizome has the functions of dispelling wind, promoting diuresis, dissipating blood stasis, relieving pain, relieving cough and reducing sputum. Can be used for treating arthralgia, jaundice due to damp-heat pathogen, amenorrhea, abdominal mass, scald due to hot water or fire, traumatic injury, carbuncle, swelling, sore, and cough with excessive phlegm.
Water chestnut flavor: is a perennial upright herb plant of the genus Calthaea of the family Aristolochiaceae. Sweet, light, slightly bitter and pungent in flavor, fragrant in smell, mild in nature and non-toxic. It can be orally administered for dispelling pathogenic wind, dispelling qi, relieving summer-heat, promoting urination, treating stranguria, and removing food stagnation. Enters the small intestine and bladder channel. It is indicated for carbuncle, furuncle and so on. It is mainly used for treating stranguria caused by sand and stone, dysuria, hematuria, rheumatic edema, common cold, headache, cough, stomachache, and pain due to long-term accumulation.
Honeysuckle stem: is a plant of the genus Lonicera of the family Caprifoliaceae, and is also known as caulis Lonicerae. Caulis Lonicerae has effects of clearing heat and detoxicating, cooling blood and stopping bleeding when stir-baked, and can be used for treating affection of exogenous wind-heat, epidemic febrile disease and fever. Can act on cardiovascular system, reduce diastolic amplitude of heart, and reduce venous pressure. Has effects in improving capillary permeability, reducing blood cholesterol, relieving spasm, eliminating phlegm, and relieving inflammation.
White peony root, radix Paeoniae alba, is a perennial herb vine of the genus Anseris belonging to the family Asclepiadaceae. Bitter, sour and slightly cold. It enters liver and spleen meridians. Pacify liver and alleviate pain, nourish blood, astringe yin and check sweating. Can be used for treating headache, vertigo, hypochondriac pain, abdominal pain, limb spasm and pain, blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, and night sweat.
Gynostemma pentaphylla: is a grass climbing plant of Cucurbitaceae and Gynostemma. The gynostemma pentaphylla is cold in nature and bitter in taste, has the effects of clearing away heat and toxic materials, relieving cough, clearing lung, eliminating phlegm, nourishing heart, soothing nerves, tonifying qi and producing sperm, can be used for reducing blood pressure and blood fat, protecting liver, promoting sleep and treating gastroenteritis, tracheitis and sphagitis, and can be used for anticancer clinical treatment of various cancers.
Licorice root: is dried root and rhizome of Glycyrrhiza uralensis Fisch, glycyrrhiza inflata Bat or Glycyrrhiza glabra L of Glycyrrhiza of Leguminosae, and contains glycyrrhizic acid, glycyrrhetinic acid, isoglycyrrhizic acid, liquiritin, mannitol, glucose, sucrose, organic acid, volatile oil, etc. Sweet in taste and neutral in nature; it enters heart, lung, spleen and stomach meridians. Has effects of invigorating qi, strengthening middle warmer, moistening lung, relieving cough, clearing away heat and toxic materials, relieving pain, and regulating drug properties. It can be used for treating spleen deficiency, asthenia, palpitation, cough, asthma, carbuncle, cellulitis, pharyngitis, poisoning, abdominal distention, and spasm and pain of limbs. Modern pharmacological studies prove that the liquorice has the effects of detoxification, diuresis, cough relief, inflammation resistance, allergy resistance and the like.
Codonopsis pilosula: is prepared from dried root of radix Codonopsis, radix Codonopsis Lanceolatae or radix Codonopsis Lanceolatae of Campanulaceae family, volatile oil, baicalein glucoside, trace alkaloid, amino acids, polysaccharide and saponin, and contains syringin, n-hexyl-beta-D-glucopyranoside, taraxacinol, friedelin, etc.; sweet and mild in nature and taste; spleen and lung meridians entered; has the effects of invigorating spleen and replenishing qi, and invigorating spleen and lung. It can be used for treating weakness of spleen and stomach, anorexia, diarrhea, asthenia, and cough with asthma due to lung deficiency. Modern pharmacological studies prove that the codonopsis pilosula has the effects of reducing blood pressure, exciting a nervous system, increasing blood sugar, promoting blood coagulation and the like.
White atractylodes rhizome: is dried rhizome of Atractylodes macrocephala Koidz of Atractylodes of Compositae, and contains atractylol, beta-eucalyptol, citronellol, atractyloether, atractyloide, dehydrated atractyloide, fructose, inulin, etc.; warm, sweet and bitter in nature and taste; spleen and stomach meridians entered; has the effects of invigorating spleen and replenishing qi, eliminating dampness and promoting diuresis, consolidating superficial resistance and arresting sweating, and invigorating qi and preventing miscarriage. It can be used for treating spleen deficiency, diarrhea, edema, spontaneous perspiration, and threatened abortion. Modern pharmacology proves that the bighead atractylodes rhizome has the effects of improving gastrointestinal functions, enhancing immune system functions, resisting tumors, promoting urination, regulating the nervous system and the like.
Chinese angelica: is root of Angelica gigas nakai of Angelica of Umbelliferae, and contains effective components such as neutral oil, acidic oil, organic acid, saccharide, vitamins, amino acids, etc.; sweet and pungent in flavor and warm in nature; it enters liver, heart and spleen meridians; has effects in replenishing blood, regulating menstruation, promoting blood circulation, relieving pain, and loosening bowel to relieve constipation. Can be used for treating blood deficiency, sallow complexion, menoxenia, amenorrhea, dysmenorrhea, blood deficiency, blood stagnation, pain due to blood cold, traumatic injury, rheumatalgia, superficial infection, pyocutaneous disease, intestinal dryness, and constipation. Modern pharmacology proves that the angelica has the effects of resisting anemia, enhancing immunologic function, inhibiting platelet aggregation, resisting thrombus, resisting myocardial ischemia and anoxia, expanding peripheral blood vessels, reducing blood pressure, exciting or inhibiting uterine smooth muscle, relaxing bronchial smooth muscle, reducing blood fat, resisting inflammation, protecting liver and the like.
Red sage root: is dried root and rhizome of Salvia miltiorrhiza Bunge of Labiatae. Has the effects of activating blood circulation to dissipate blood stasis, stimulating the menstrual flow to relieve pain, clearing away the heart-fire and relieving restlessness, cooling blood and eliminating carbuncle. Can be used for treating thoracic obstruction, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain.
Astragalus root: is dried root of Leguminosae plant radix astragali, mongolian radix astragali, or other similar plants of the same genus, and contains effective components such as polysaccharide and saponins; mild and sweet in nature and taste; entering lung and spleen meridians; has the effects of invigorating qi, invigorating yang, consolidating superficial resistance, arresting sweating, promoting skin ulcer and granulation, and inducing diuresis to alleviate edema. It can be used for treating deficiency of qi of spleen and lung, collapse of qi, sweating due to exterior deficiency, sore, carbuncle, ulcer, and edema due to qi deficiency. Modern pharmacology proves that astragalus has the effects of enhancing immunity, promoting hematopoiesis, improving gastrointestinal tract function, regulating heart, regulating blood pressure, resisting tumor, radiation, fatigue, oxidative damage and protecting liver.
And (3) eclipta: is dried aerial part of eclipta prostrata of eclipta of Compositae. Has the effects of nourishing liver and kidney, cooling blood and stopping bleeding. It is commonly used for treating liver and kidney yin deficiency, odontoseisis, premature gray hair, vertigo, tinnitus, soreness and weakness of waist and knees, yin deficiency, blood heat, hematemesis, epistaxis, hematuria, bloody dysentery, metrorrhagia, metrostaxis, hemorrhage due to trauma.
Bupleurum root: is dried root of Bupleurum scorzonerifolium or Bupleurum scorzonerifolium of Umbelliferae. Bupleurum root, radix bupleuri is a commonly used exterior syndrome relieving drug. Is also called as Diwu, potherb mustard, mushroom grass and firewood, is bitter in nature and taste, slightly cold, and enters liver and gallbladder meridians. Has the functions of harmonizing exterior and interior, soothing liver and invigorating yang. Can be used for treating common cold, fever, alternating chills and fever, malaria, stagnation of qi due to stagnation of liver-qi, distending pain of chest and hypochondrium, proctoptosis, uterine prolapse, and menoxenia.
Tuckahoe, poria cocos: is dried sclerotium of Poria cocos (Schw.) wolf of Polyporaceae family, and contains effective components such as beta-pachyman, pachymin, pachymic acid, acetyl pachymic acid, pinoceric acid, odontic acid, 3 beta-hydroxy lanoceric acid, histidine, choline, adenine, etc.; mild, sweet and light in nature and taste; it is entered into heart, lung, spleen, stomach and kidney meridians; has the effects of promoting diuresis, eliminating dampness, invigorating spleen, strengthening middle warmer, calming heart, and tranquilizing mind. It can be used for treating phlegm-damp edema, oliguria, spleen deficiency, anorexia, loose stool, diarrhea, and restlessness. Modern pharmacology proves that the tuckahoe has the effects of promoting diuresis, soothing the nerves, resisting inflammation, inhibiting bacteria, resisting tumors, improving the immunologic function, protecting the liver, resisting rejection reaction, promoting the hematopoietic function and the like.
Dried orange peel: dried mature pericarp of mandarin orange of Citrus of Rutaceae and its cultivar contains nobiletin, hesperidin, neohesperidin, hesperetin, parahydroxyforrin, flavone compounds, etc. Pungent and bitter in nature and warm in nature; it enters spleen and lung meridians. Has effects of regulating qi-flowing, invigorating spleen, eliminating dampness and phlegm. Can be used for treating qi stagnation of spleen and stomach, emesis, singultus, damp phlegm, cough due to cold phlegm, and thoracic obstruction. Modern pharmacological research proves that the dried orange peel has the effects of removing oxygen free radicals, resisting lipid peroxidation, benefiting gallbladder, reducing serum cholesterol and the like.
And (3) frying the hawthorn: the hawthorn is a traditional Chinese medicine raw material used as both medicine and food, and has the effects of promoting digestion, invigorating stomach, promoting qi circulation, dissipating fatigue, eliminating turbid pathogen and reducing blood fat. Can be used for treating dyspepsia, abdominal distention, dysentery, abdominal pain, amenorrhea, puerperal fatigue, heart and abdominal pain, thoracic obstruction, cardialgia, hernia pain, hyperlipidemia, etc.
Organic yeast selenium: organic selenium yeast, namely Selenium Yeast (SY), namely yeast strains which realize specific high-sulfur requirements according to the chemical similarity of selenium and sulfur absorb selenium from a culture medium extremely lacking sulfur elements, the selenium absorbed into cells is integrated into a protein structure of yeast cells, and finally, the selenium yeast is washed by water to remove inorganic selenium outside the cells, so that the yeast organic selenium is obtained. The organic selenium yeast is added into the daily ration of the pigs, so that the pig feed has the nutritional functions of promoting the growth of the pigs, enhancing the immune function, improving the reproductive performance, improving the pork quality and the like. Not only can improve the selenium content in the body, but also can produce selenium-rich food to improve the health of human beings.
The invention is further illustrated with reference to specific examples. It should be understood that the specific embodiments described herein are illustrative only and are not limiting upon the scope of the invention.
The examples do not show the specific techniques or conditions, according to the technical or conditions described in the literature in the field, or according to the product specifications. The reagents or instruments used are conventional products which are not known to manufacturers and are available from normal sources.
The experimental procedures in the following examples are conventional unless otherwise specified. The test materials used in the following examples are all commercially available products unless otherwise specified.
Preparation examples:
example 1:
a traditional Chinese medicine composition for improving sub-health of sows is prepared from the following raw materials in parts by weight: 30 parts of silybum marianum, 30 parts of giant knotweed rhizome, 20 parts of water chestnut, 10 parts of honeysuckle stem, 10 parts of white paeony root, 5 parts of gynostemma pentaphylla, 15 parts of liquorice, 3 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 5 parts of Chinese angelica, 1 part of salvia miltiorrhiza, 2 parts of astragalus mongholicus, 2 parts of eclipta, 5 parts of radix bupleuri, 5 parts of poria cocos, 5 parts of dried orange peel, 3 parts of fried hawthorn and 2 parts of organic yeast selenium.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) Weighing the raw materials according to the weight ratio, mixing the raw materials except the raw materials dried by the organic yeast, and crushing into coarse powder;
(2) Adding 8 times of water into the coarse powder, extracting at 50 deg.C for 3 hr, and transferring to fermentation tank;
(3) Adding white sugar 0.5 times of the total weight of the above raw materials except organic yeast selenium, stirring, cooling to 35 deg.C, adding yeast 0.07% of the total weight of the above raw materials, fermenting for 7 days, fermenting with 200 mesh filter cloth, and filtering to obtain fermentation liquid;
(4) Vacuum freeze drying the fermented liquid to powder;
(5) And crushing the dried materials, adding organic selenium yeast, and mixing for 20 minutes to obtain the product of example 1.
Example 2:
a traditional Chinese medicine composition for improving sub-health of sows is prepared from the following raw materials in parts by weight: 25 parts of silybum marianum, 30 parts of giant knotweed rhizome, 30 parts of water chestnut, 15 parts of honeysuckle stem, 5 parts of white paeony root, 10 parts of gynostemma pentaphylla, 10 parts of liquorice, 5 parts of codonopsis pilosula, 8 parts of bighead atractylodes rhizome, 10 parts of Chinese angelica, 5 parts of salvia miltiorrhiza, 5 parts of astragalus mongholicus, 5 parts of eclipta, 3 parts of radix bupleuri, 3 parts of poria cocos, 3 parts of dried orange peel, 5 parts of fried hawthorn and 5 parts of organic yeast selenium.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) Weighing the raw materials according to the weight ratio, mixing the raw materials except the raw materials dried by the organic yeast, and crushing the mixture into coarse powder;
(2) Adding 10 times of water into the coarse powder, extracting at 60 deg.C for 2 hr, and transferring to fermentation tank;
(3) Adding white sugar 1 time of the total weight of the above raw materials except organic yeast selenium, stirring, cooling to 35 deg.C, adding yeast 0.1% of the total weight of the above raw materials, fermenting for 7 days, fermenting with 200 mesh filter cloth, and filtering to obtain fermentation liquid;
(4) Vacuum freeze drying the fermented liquid to powder;
(5) And crushing the dried materials, adding organic selenium yeast, and mixing for 20 minutes to obtain the product of example 2.
Comparative example 1:
a traditional Chinese medicine composition for improving sub-health of sows is prepared from the following raw materials in parts by weight: 30 parts of silybum marianum, 50 parts of water chestnut, 10 parts of honeysuckle stem, 10 parts of white peony root, 5 parts of gynostemma pentaphylla, 15 parts of liquorice, 3 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 5 parts of angelica, 1 part of salvia miltiorrhiza, 2 parts of astragalus, 2 parts of eclipta, 5 parts of radix bupleuri, 5 parts of poria cocos, 5 parts of dried orange peel, 3 parts of fried hawthorn and 2 parts of organic yeast selenium.
The preparation method of the traditional Chinese medicine composition is the same as that of the embodiment 1.
Comparative example 2:
a traditional Chinese medicine composition for improving sub-health of sows is prepared from the following raw materials in parts by weight: 30 parts of silybum marianum, 30 parts of lophatherum gracile, 20 parts of water chestnut, 10 parts of honeysuckle stem, 10 parts of white peony root, 5 parts of gynostemma pentaphylla, 15 parts of liquorice, 3 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 5 parts of angelica, 1 part of salvia miltiorrhiza, 2 parts of astragalus mongholicus, 2 parts of eclipta, 5 parts of radix bupleuri, 5 parts of poria cocos, 5 parts of dried orange peel, 3 parts of fried hawthorn and 2 parts of organic yeast selenium.
The preparation method of the traditional Chinese medicine composition is the same as that of the embodiment 1.
Comparative example 3:
a traditional Chinese medicine composition for improving sub-health of sows is prepared from the following raw materials in parts by weight: 30 parts of silybum marianum, 30 parts of giant knotweed rhizome, 20 parts of water chestnut, 10 parts of honeysuckle stem, 10 parts of white paeony root, 5 parts of gynostemma pentaphylla, 15 parts of liquorice, 3 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 5 parts of Chinese angelica, 1 part of salvia miltiorrhiza, 2 parts of astragalus mongholicus, 2 parts of eclipta, 5 parts of radix bupleuri, 5 parts of poria cocos, 5 parts of dried orange peel, 3 parts of fried hawthorn and 2 parts of organic yeast selenium.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) Weighing the raw materials according to the weight ratio, mixing the raw materials except the raw materials dried by the organic yeast, and crushing into coarse powder;
(2) Adding 8 times of water into the coarse powder, and extracting at 50 deg.C for 3 hr;
(3) Vacuum freeze-drying the extracting solution obtained in the step (2) to be powder; and
(4) And crushing the dried materials, adding organic selenium yeast, and mixing for 20 minutes to obtain the comparative example 3.
Effect embodiment: the traditional Chinese medicine composition improves the sub-health of the sowHealth-promoting action
1. Test materials
In a certain scale pig farm in Shenyang city of Liaoning, 500 big white and Changbai binary sows are selected, 56 sows with similar expected delivery periods and under sub-health conditions are divided into 7 groups, and each group comprises 8 sows, and the specific grouping conditions are as follows:
(1) Blank control group: 5 multiparous sows and 3 replacement sows;
(2) Example 1 group: 6 multiparous sows and 2 replacement sows;
(3) Example 2 group: 6 multiparous sows and 2 replacement sows;
(4) Comparative example 1 group: 5 multiparous sows and 3 replacement sows;
(5) Comparative example 2 group: 6 multiparous sows and 2 replacement sows;
(6) Comparative example 3 group: 5 multiparous sows and 3 replacement sows;
(7) Positive control group: 6 multiparous sows and 2 replacement sows.
2. Test method
The test time is from 90 days of gestation to hybridization, namely 10 days at 7 months to 28 days at 9 months in 2022, and the total time is 80 days, and all the sows finish production within 80 days.
(1) The sows in the placebo group were fed with the normal feed only. (2) The group (7) is directly mixed with common feed and fed with 1kg of adjuvant mixed with 1000kg of feed, and the positive control group is Astragalus membranaceus and fructus Ligustri Lucidi immunity enhancing granule, and contains radix astragali, herba Epimedii, fructus Ligustri Lucidi, radix Codonopsis, atractylodis rhizoma, radix Angelicae sinensis, cimicifugae rhizoma, bupleuri radix, pericarpium Citri Tangerinae, and Glycyrrhrizae radix as main ingredients. (1) The (7) groups were all fed continuously for 80 days, and the amount of crude drug added to the feed was the same in the (2) to (7) groups.
During the test, the groups were kept under the same conditions, and the feed, the environment of the breeding and the immunization were the same.
3. Test results
3.1 sow status before experiment
The 56 sows included in the test had severe overall sub-health, messy hair, and white or yellow skin with tear spots and swelling.
3.2 average number of born sows per group
The results of the experiment are shown in table 1. The experiment results show that the average farrowing number of the sows in each experiment group has small overall difference. However, some trend can be seen, and the average litter size of the sows in each administration group is slightly higher than that of the blank control group, which indicates that the sub-health condition of the sows can be improved to different degrees after administration. Wherein the sows in the groups of example 1 and example 2 have the largest litter size, which is slightly higher than that in the groups of comparative examples 1-3 and the positive control group. In comparative examples 1 to 3, in which the average farrowing number of the sows in comparative example 3, which were not subjected to the fermentation treatment, was the lowest, it was suggested that the fermentation treatment may have a high influence on the efficacy of the Chinese medicinal composition of the present invention, and the average farrowing number of the sows in comparative examples 1 to 2 was also lower than that in examples 1 to 2, suggesting that the formulation of the Chinese medicinal composition of the present invention also has an important influence on the efficacy thereof, and when part of the medicinal flavor was omitted or replaced with another medicinal flavor, the effect may be influenced to a different extent.
3.3 weight of weaned piglets in each group for 25 days
The weight of the piglets can not only reflect the health condition of the piglets, but also indirectly reflect the overall health state of the sows. In the experimental process, the weight of piglets in each administration group (particularly in the groups of examples 1-2) with the same day age is different from that of piglets in a blank control group, the piglets in the administration groups are generally plump in appearance and glossy in hair color, and the piglets in the blank control group are sunken in the ribs and have poor overall mental status.
The results of the experiment are shown in table 1. The experimental results show that the weaning weight of each experimental group in 25 days is higher than that of the blank control group in different degrees. The weaned weight of the piglets in the group of example 1 and the group of example 2 is the highest in 25 days, and is obviously higher than that of the groups of comparative examples 1-3 and the positive control group. In comparative examples 1-3, the piglets in comparative example 3, which were not fermented, had the lowest weaned weight for 25 days, which was only slightly higher than that in the blank control group, and this result suggests that the fermentation treatment may have a higher effect on the efficacy of the Chinese medicinal composition of the present invention, and the piglets in comparative examples 1-2, which had weaned weights for 25 days, were also lower than those in examples 1-2, suggesting that the formulation of the Chinese medicinal composition of the present invention also has an important effect on the efficacy thereof, and may have a different degree of effect on the efficacy thereof when part of the medicinal flavor is omitted or replaced with another medicinal flavor.
3.4 oestrus rates of sows in groups within 7 days
The non-productive days of the sows are closely related to the profitability of a pig farm, and the problem has greater influence on a large-scale pig farm. Therefore, the oestrus condition of the sow within 7 days after weaning directly reflects the health state of the sow and the profitability condition of a pig farm.
The results of the experiment are shown in table 1. The experiment results show that the oestrus rates of sows in each experiment group within 7 days after weaning are all higher than those in the blank control group in different degrees. Wherein, the oestrus rate of the sows in the group of the example 1 and the group of the example 2 within 7 days after weaning is the highest and is 100 percent, which is obviously higher than that of the groups of the comparative examples 1 to 3 and the positive control group. Among the comparative examples 1 to 3, the sow of comparative example 3, which was not subjected to the fermentation treatment, had the lowest oestrus rate within 7 days after weaning (62.5%), but slightly higher than the positive control (50%), which suggests that the fermentation treatment may have a higher influence on the medicinal effects of the Chinese medicinal composition of the present invention, and the sow of comparative examples 1 to 2 also had a lower oestrus rate within 7 days after weaning than those of examples 1 to 2, suggesting that the formulation of the Chinese medicinal composition of the present invention also has an important influence on the medicinal effects thereof, and may have different degrees of influence on the medicinal effects when a part of the medicinal taste is omitted or replaced with another medicinal taste.
3.4 food intake of sows in each group
The food intake of the sow is directly related to the milk of the sow, the fat condition of the sow in the lactation period, the oestrus after weaning and the like. However, the test is carried out in summer, and most pig farms have the problem of low feed intake of the swinery at the moment.
The results of the experiment are shown in table 1. The experiment results show that the food intake of the sows in each experiment group is higher than that of the sows in the blank control group in different degrees. The sow in the group of example 1 and the sow in the group of example 2 has the highest food intake, which is obviously higher than that of the group of comparative examples 1-3 and the positive control group. In comparative examples 1 to 3, in which the sows in comparative example 3, which were not subjected to the fermentation treatment, had the lowest food intake, the results suggest that the fermentation treatment may have a higher effect on the efficacy of the Chinese medicinal composition of the present invention, and that the sows in comparative examples 1 to 2 also had a lower food intake than those in examples 1 to 2, suggesting that the formulation of the Chinese medicinal composition of the present invention also has an important effect on the efficacy thereof, and may have a different degree of effect on the efficacy thereof when a part of the medicinal flavor is omitted or replaced with another medicinal flavor.
3.5 improvement of sub-health symptoms in the sows of each group
The results of the experiment are shown in table 1. The experimental results show that the improvement conditions of the sub-health symptoms of the sows in each experimental group are all better than those of the blank control group in different degrees. The improvement conditions of the sub-health symptoms of the sows in the groups of example 1 and example 2 are the best, the improvement conditions are all 100%, the skins of all the sows recover to be light red, the tear spots and the swollen sacs are eliminated, or the skin color is faded, the tear spots and the swollen sacs are reduced, and the experimental results are obviously better than those of the groups of comparative examples 1-3 and the positive control group. In comparative examples 1 to 3, the improvement of the sub-health status of the sows in comparative example 3, which was not subjected to the fermentation treatment, was the least desirable, and this result suggests that the fermentation treatment may have a higher effect on the efficacy of the Chinese medicinal composition of the present invention, and that the improvement of the sub-health status of the sows in comparative examples 1 to 2 is inferior to that in examples 1 to 2, suggesting that the formulation of the Chinese medicinal composition of the present invention also has a significant effect on the efficacy thereof, and may have a different degree of effect on the efficacy thereof when a part of the medicinal flavor is omitted or replaced with another medicinal flavor.
Table 1: the traditional Chinese medicine composition has the function of improving the sub-health aspect of sows
Note: the improvement of the sub-health symptoms comprises the obvious improvement of the sub-health symptoms and the total number of improved animals, wherein the obvious improvement refers to the restoration of the pale red skin of the sow and the elimination of the tear spots and the swollen sacs. "improvement" means that the color of the sow skin has subsided, and the tear spots and the swollen sacs have decreased. "sub-health status" means that the sow has white or yellowish skin with tear spots and swollen sacs.
In conclusion, the traditional Chinese medicine composition and the fermented traditional Chinese medicine preparation can comprehensively improve the sub-health state of the sow and improve the health degree of the sow, so that the breeding rate of the replacement sow is improved, the two-fetus syndrome of the sow is remarkably reduced, the lachrymal edema of the multiparous sow is eliminated, the skin is reddish, the sub-health state of the sow is eliminated, the oestrus mating is recovered to be normal, and the elimination rate of the sow is reduced. Moreover, during the whole experiment period, no toxic and side effects of the traditional Chinese medicine composition and the fermented traditional Chinese medicine preparation are observed in the experimental sow.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (10)
1. A traditional Chinese medicine composition for improving the sub-health of sows is characterized in that: the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-30 parts of silybum marianum, 20-30 parts of giant knotweed, 20-30 parts of water chestnut, 10-15 parts of honeysuckle stem, 5-10 parts of white peony root, 5-10 parts of gynostemma pentaphylla, 10-15 parts of liquorice, 1-5 parts of codonopsis pilosula, 5-10 parts of bighead atractylodes rhizome, 5-10 parts of Chinese angelica, 1-5 parts of salvia miltiorrhiza, 1-5 parts of astragalus membranaceus, 1-5 parts of eclipta, 1-5 parts of radix bupleuri, 1-5 parts of poria cocos, 1-5 parts of dried orange peel, 1-5 parts of fried hawthorn and 1-5 parts of organic yeast selenium.
2. The traditional Chinese medicine composition according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25-30 parts of silybum marianum, 25-30 parts of polygonum cuspidatum, 20-30 parts of water chestnut, 10-15 parts of honeysuckle stem, 5-10 parts of white peony root, 5-10 parts of gynostemma pentaphylla, 10-15 parts of liquorice, 3-5 parts of codonopsis pilosula, 5-8 parts of bighead atractylodes rhizome, 5-10 parts of angelica, 1-5 parts of salvia miltiorrhiza, 2-5 parts of astragalus membranaceus, 2-5 parts of eclipta, 3-5 parts of radix bupleuri, 3-5 parts of poria cocos, 3-5 parts of dried orange peel, 3-5 parts of fried hawthorn and 2-5 parts of organic yeast selenium.
3. A method for preparing the traditional Chinese medicine composition of claim 1 or claim 2, which is characterized in that: the preparation method comprises the following steps:
(1) Weighing raw materials in each weight ratio, mixing the raw materials except the raw materials dried by the organic yeast, and crushing;
(2) Adding 8-10 times of water into the raw material powder except organic selenium yeast, extracting at 50-60 deg.C for 2-3 hr, and transferring into fermentation tank;
(3) Adding white sugar 0.5-1 times of the total weight of the above materials except organic selenium yeast, stirring, cooling to 35 deg.C, fermenting for 5-7 days, and filtering to obtain fermentation broth;
(4) Drying the fermentation broth;
(5) And (4) adding organic selenium yeast into the dried material obtained in the step (4), and mixing for 20-30 minutes to obtain the selenium-enriched dried material.
4. The production method according to claim 3, characterized in that: in the step (3), adding fermentation strains accounting for 0.05-0.1% of the total weight of the raw materials for fermentation, wherein the filtration is 200-mesh filter cloth filtration, and in the step (4), the drying method is vacuum freeze drying, spray drying or vacuum drying.
5. The method of claim 4, wherein: in step (3), the fermentation species is selected from one or more of: yeast, lactic acid bacteria, bacillus or enzyme.
6. A fermented traditional Chinese medicine preparation for improving the sub-health of sows is characterized in that: the fermented traditional Chinese medicine preparation comprises the traditional Chinese medicine composition of claim 1 or claim 2, or the traditional Chinese medicine composition prepared by the preparation method of any one of claims 3 to 5.
7. Use of the traditional Chinese medicine composition of claim 1 or claim 2 or the fermented traditional Chinese medicine preparation of claim 6 in the preparation of a medicament for improving sub-health of sows.
8. Use according to claim 7, characterized in that: the application is to improve the breeding rate of replacement gilts, reduce the second-birth syndrome of the sows, eliminate lacrimation and swelling bags of the multiparous sows, restore the reddish skin, eliminate the sub-health state of the sows, restore the oestrus and mating of the sows to be normal, and reduce the elimination rate of the sows.
9. Use of the traditional Chinese medicine composition of claim 1 or claim 2 or the fermented traditional Chinese medicine preparation of claim 6 in the preparation of a feed for improving sub-health of sows.
10. Use according to claim 9, characterized in that: the traditional Chinese medicine composition or the fermented traditional Chinese medicine preparation is added into the feed in a weight percentage of 0.05-0.5%.
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| CN116966230A (en) * | 2023-09-11 | 2023-10-31 | 山东利邦牧业股份有限公司 | Fermented traditional Chinese medicine composition for preventing and controlling porcine reproductive and respiratory syndrome as well as preparation method and application thereof |
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| CN109589361A (en) * | 2017-09-30 | 2019-04-09 | 河南牧动物药业有限公司 | A kind of Chinese medicine composition for improving sow fertility rate, Chinese materia medica preparation and preparation method thereof |
| CN114848763A (en) * | 2022-03-25 | 2022-08-05 | 河南牧业经济学院 | Traditional Chinese medicine composition for sows in gestation period and/or lactation period, fermented traditional Chinese medicine preparation and preparation method thereof |
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| CN109589361A (en) * | 2017-09-30 | 2019-04-09 | 河南牧动物药业有限公司 | A kind of Chinese medicine composition for improving sow fertility rate, Chinese materia medica preparation and preparation method thereof |
| CN114848763A (en) * | 2022-03-25 | 2022-08-05 | 河南牧业经济学院 | Traditional Chinese medicine composition for sows in gestation period and/or lactation period, fermented traditional Chinese medicine preparation and preparation method thereof |
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| CN116966230A (en) * | 2023-09-11 | 2023-10-31 | 山东利邦牧业股份有限公司 | Fermented traditional Chinese medicine composition for preventing and controlling porcine reproductive and respiratory syndrome as well as preparation method and application thereof |
| CN116966230B (en) * | 2023-09-11 | 2024-04-19 | 山东利邦牧业股份有限公司 | Fermented traditional Chinese medicine composition for preventing and controlling porcine reproductive and respiratory syndrome as well as preparation method and application thereof |
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