CN109674999A - A kind of Radix Astragali, rhizoma zingiberis composite extract and its preparation method and application - Google Patents
A kind of Radix Astragali, rhizoma zingiberis composite extract and its preparation method and application Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/9068—Zingiber, e.g. garden ginger
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Abstract
The present invention provides a kind of Radix Astragalis, rhizoma zingiberis composite extract and its preparation method and application, the Radix Astragali, rhizoma zingiberis composite extract according to parts by weight, including following component and proportion: rhizoma zingiberis 30-45 parts by weight, tuber of pinellia 20-35 parts by weight, Radix Astragali 8-15 parts by weight, Radix Paeoniae Alba 6-12 parts by weight, faenum graecum 10-20 parts by weight, dark plum 6-8 parts by weight, evodia rutaecarpa 12-20 parts by weight, Radix Glycyrrhizae 5-8 parts by weight.Radix Astragali produced by the present invention, rhizoma zingiberis composite extract are added into feed by the 0.5%-1% dispersion of pig starter feed quality, feeding is in weanling pig, can be applied to weanling pig stress prevention and treatment improve the growing state of weanling pig to improve the anti-stress ability of weanling pig.
Description
Technical field
The invention belongs to veterinary formulations fields, and in particular to a kind of Radix Astragali, rhizoma zingiberis composite extract and preparation method thereof and
Using.
Background technique
With intensive, the large-scale development of pig breeding industry, the early weaning of piglet, which has become in pig production, generally to be taken
Means.But due to the digestive system of early-weaned piglets not yet develop it is perfect, it is difficult to bear by breast milk to feed conversion, son
Pig will appear very big biology stress, cause a series of neuroendocrines to change, lead to gastrointestinal physiology, microbial flora and immune
The variation of power brings a series of adverse effects to piglet development, is mainly shown as diarrhea, appetite stimulator, slow growth
It even stagnates, have the fidgets, aggressive situations such as reinforcing, influencing the growth of piglet simultaneously, or even will cause piglet death, be existing
For one of the major issue faced in pig production.
Currently, most of poultry feeders for during weaned piglet stress situation, mostly use add antibiosis in feed greatly
The additives such as element, probiotics, oligosaccharide and enzyme preparation add although can alleviate weaning stress of piglet reaction to a certain extent
The speed of growth of speed raising animal, but the addition of antibiotic, can have the problems such as medicament residue and drug resistance, gradually be limited
Dosage.
Chinese medicine additive has many advantages, such as that effect is good, toxic side effect is small, drug residue is low, from a wealth of sources, cheap,
The effects of being commonly used to disease-prevention health, improving breeding performonce fo animals, improve animal product quality and improve feed quality.Chinese medicine adds
Agent is added to have become as drug residue free, environment-protecting feed additive pollution-free and that raise benefit can also be improved concerned by people
Focus is widely studied and applied.Such as:
One kind is disclosed in CN1957742 " a kind of weanling pig Chinese medicine compound prescription ultra micro powder feed additive and preparation method "
The immune function of early-weaned piglets, the Chinese medicine composition of digestion and absorption function and growth performance, the combination can be significantly improved
Object is formulated by a certain percentage by drugs such as Radix Astragali, wilsonii, Radix Codonopsis, hawthorn, Radix Salviae Miltiorrhizae and chitosan oligosaccharides, the steps include: first
Radix Astragali, wilsonii, Radix Codonopsis, hawthorn and Radix Salviae Miltiorrhizae are distinguished into dissection；Secondly by Radix Astragali, wilsonii, Radix Codonopsis, hawthorn and the pellet after dissection
Ginseng crushes respectively；Third is that a certain proportion of Radix Astragali, wilsonii, Radix Codonopsis, hawthorn, Radix Salviae Miltiorrhizae and chitosan oligosaccharide pulvis is taken to be sufficiently mixed；
Fourth is that further make ultramicro crushing treatment for said mixture, makes 30 μm of average grain diameter, is sealed after packing.
Disclosing one kind in CN104886345 " a kind of the Chinese materia medica preparation of preventing post-weaning diarrhea and preparation method thereof " can
To significantly improve the immunity of piglet and effectively the Chinese medicine composition of diarrhea phenomenon, the composition occur after prevention weaned piglet
Including dandelion extract, Astragalus Root P.E, Andrographis Paniculata, houttuynia extract and glucose, by by above-mentioned plant
Extract mixes after crossing 50-70 mesh, and the Chinese materia medica preparation is prepared in the glucose mixing after being subsequently added into 70-100 mesh.
Summary of the invention
The present invention provides a kind of Radix Astragali, rhizoma zingiberis composite extract, which contains Chinese herbal medicine extract, formula section
Learn, can effectively improve weanling pig anti-stress ability, mitigate piglet stress caused by diarrhea, the low problem of appetite, enhancing
The resistance of piglet, to improve the growth performance of piglet.
It is a further object to provide the preparation method and application of a kind of above-mentioned Radix Astragali, rhizoma zingiberis composite extract.
To achieve the goals above, the invention provides the following technical scheme:
The present invention provides a kind of Radix Astragalis, rhizoma zingiberis composite extract, and the Radix Astragali, rhizoma zingiberis composite extract are in parts by weight
Meter, including following component and proportion:
Rhizoma zingiberis 30-45 parts by weight, tuber of pinellia 20-35 parts by weight, Radix Astragali 8-15 parts by weight, Radix Paeoniae Alba 6-12 parts by weight, faenum graecum
10-20 parts by weight, dark plum 6-8 parts by weight, evodia rutaecarpa 12-20 parts by weight, Radix Glycyrrhizae 5-8 parts by weight.
Further, the Radix Astragali, further include 1-2 parts by weight flavone of hawthorn fruit and 1-3 parts by weight in rhizoma zingiberis composite extract
Algal polysaccharides.
The present invention also provides the preparation methods of a kind of Radix Astragali, rhizoma zingiberis composite extract, specifically comprise the following steps:
(1) each raw material are weighed by recipe ratio, rhizoma zingiberis, the tuber of pinellia, Radix Paeoniae Alba, evodia rutaecarpa, Radix Glycyrrhizae crush after with astragalus mongholicus tablet, dark plum
Mixing puts into the water logging 0.5-2h of 10-20 times of quality, and later, heating and cooking 0.5-1.5h, filtering continues to add into filter residue
Enter the water of 5-10 times of quality, heating and cooking 0.5-1h, filtering merges filtrate twice, is concentrated into cream liquid concentration in 1: 1-1:2 range
It is interior, obtain primary extract；
(2) ethanol solution of certain mass is added into primary extract under agitation, until ethanol content is in 50%-60%
Afterwards, 24-48h is stood, is filtered to remove sediment, filtrate volatilizes the ethanol solution that certain mass is added after ethyl alcohol again, until ethyl alcohol
Content stands 24-48h, is filtered to remove sediment, filtrate is concentrated and dried after 60%-80%, i.e., acquisition Radix Astragali, rhizoma zingiberis are multiple
Close extract.
Further, in the preparation method of the additive for fodder of the weanling pig, by the flavone of hawthorn fruit of recipe ratio
The plant extracts obtained with algal polysaccharides investment step (2) is uniformly mixed.
Radix Astragali produced by the present invention, rhizoma zingiberis composite extract disperse addition by the 0.5%-1% of piglet basal feed quality
In feed, feeding in weanling pig, can be applied to weanling pig stress prevention and treatment, to improve the resisting stress energy of weanling pig
Power improves the growing state of weanling pig.
Radix Astragali provided by the invention, rhizoma zingiberis composite extract prescription are scientific and reasonable, and the Radix Astragali in side is sweet in flavor and warm in property, can benefit
Its " shape insufficient " is mended in gas righting, and rhizoma zingiberis, the tuber of pinellia are all hot product, can warming spleen and stomach for dispelling cold, its solid table, being aided with property is sour, puckery, taste
Flat dark plum, acid receive antidiarrheal, nourishing Yin and promoting production of body fluid, in addition the evodia rutaecarpa of the Radix Paeoniae Alba of taste bitter and cold and heat bitter in taste, can hold back high and level tone sun, most
For importantly, joined faenum graecum and Radix Glycyrrhizae, faenum graecum can warming kidney and enhancing yang, Radix Glycyrrhizae is clearing heat and detoxicating, replenish qi to invigorate the spleen, reconcile it is all
Medicine；Above-mentioned all medicine compatibilities play middle benefit gas tonifying Qi, the benefits of table is consolidated in cold dispelling altogether, and insufficiency of vital energy and blood, the deficiency of yang include before and after treatment weaned piglet,
Simultaneous treatment of principal and subordinate symptoms, significant effect.In addition, the present invention is also organic by Radix Astragali, rhizoma zingiberis composite extract and flavone of hawthorn fruit and algal polysaccharides
In conjunction with enhancing its effect, improve the anti-stress ability to weanling pig.
The present invention compared to the prior art, the beneficial effect is that:
1, Radix Astragali of the invention, rhizoma zingiberis composite extract include Chinese herbal medicine extract, and formula science improves weanling pig
Anti-stress ability reduces diarrhea of the piglet before and after wean, situations such as appetite is low, improves the growing state of weanling pig；
2, the feed addictive of Radix Astragali of the invention, rhizoma zingiberis composite extract as weanling pig, highly-safe, malicious secondary work
With it is small, have no drug resistance.
Specific embodiment
Combined with specific embodiments below, the present invention is further described.
It should be noted that the relevant criterion in the foundation " Chinese Pharmacopoeia " 2015 editions of raw material used in the present invention, mirror
It is set to raw material that is qualified and determining.
Rhizoma zingiberis is the dry rhizome of zingiber Zingiber officinale Rose..Pungent, heat is dissipated with middle benefit gas
It is cold, the benefits of recover Yang and smooth venation, warming lung and resolving fluid.For coldness and pain in the epigastrium, vomiting and diarrhea, cold weak pulse of limb is cold to drink the treatment breathed with cough.
The tuber of pinellia is the dry tuber of aroid tuber of pinellia Pinellia ternata (Thunb.) Breit., according to
Concocting method is different, and the medicine materical crude slice kind such as be divided into prepared RHIZOMA PINELLIZE without adju-vant, pinellia, rhizoma pinellinae praeparata, respectively has the characteristics that different effects.At this
The tuber of pinellia used in invention is pinellia, pungent, warm, has the benefits of middle benefit gas resolving sputum, stopping nausea and vomiting by lowering the adverse flow of QI.For phlematic vomiting, gastral cavilty ruffian
Full treatment, other tuber of pinellia drinks can also be used in the present invention.
Radix Astragali is leguminous mongolian scutellaria Astragalus membranaceus (Fisch.)
Bge.var.mongholicus (Bge.) Hsiao or Astragalus membranacus Astragalus membranaceus (Fisch.) Bge.'s
Dry root.Sweet, tepor has tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, shengjin nourishing, move stagnation and palsy, pus draining and toxin expelling, sore
The benefits of myogenic.For deficiency of vital energy and acking in strength, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy and edema,
Heat Diabetes, blood deficiency chlorosis, hemiplegia, numbness pain is numb, ulcer is difficult to burst, the treatment of burst for a long time and does not holds back.
Radix Paeoniae Alba is the dry root of cohosh Chinese herbaceous peony Paeonia lactiflora Pall..Bitter, acid, it is slightly cold, have
The benefits of nourishing blood for regulating menstruation, astringing YIN to stop sweating, soft liver analgesic, suppressing liver-YANG.For blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat, hypochondriac pain,
Abdominal pain, four limbs contraction pain, the treatment of headache and dizziness.
Faenum graecum is the dry mature seed of leguminous plant fenugreek Trigonella foenum-graecum L..Tool
There is the benefits of warming kidney and enhancing yang, cold-dispelling pain-relieving.For the insufficiency of the kidney yang, below element deficiency and cold, cold and pain in the lower abdomen, cold hernia stomachache, the disturbance of lower legs due to pathogenic cold and dampness controlled
It treats.Method identification of the faenum graecum according to " Chinese Pharmacopoeia " 2010 editions records.
Dark plum is the drying almost ripe fruit of rose department plant plum Prunus mume (Sieb.) Sieb.et Zucc..
It is sour, puckery, it puts down, there is astringing lung-QI, the benefits of puckery intestines promote the production of body fluid, claming ascaris.For chronic cough of deficiency lung, protracted dysentery and diarrhea, abnormal heat is quenched one's thirst, ascariasis of biliary tract vomiting
The treatment of abdominal pain.
Evodia rutaecarpa is rutaceae evodia rutaecarpa Euodia rutaecarpa (Juss.) Benth., Shi Hu Euodia
Rutaecarpa (Juss.) Benth.var.officinalis (Dode) Huang or thin hair evodia rutaecarpa Euodia
The drying almost ripe fruit of rutaecarpa (Juss.) Benth.var.bodinieri (Dode) Huang.Pungent, bitter, heat has
The benefits of eliminating cold to stop pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For jueyin headache, cold hernia stomachache, the disturbance of lower legs due to pathogenic cold and dampness, dysmenorrhea, stomach duct and abdomen is swollen
Bitterly, acid regurgitation, the treatment of Diarrhoea are vomitted.
Radix Glycyrrhizae is glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza
The dry root and rhizome of inflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L..Sweet and neutral has and invigorates the spleen and benefits qi,
It is clearing heat and detoxicating, the benefits of expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, fatigue and weakness, shortness of breath and palpitation, phlegm of coughing
More, stomach duct and abdomen, four limbs contraction, carbuncle sore tumefacting virus alleviate drug toxicity, strong.
Example of formulations:
1 Radix Astragali of preparation, the preparation of rhizoma zingiberis composite extract
Formula: 30 parts by weight of rhizoma zingiberis, 22 parts by weight of the tuber of pinellia, 9 parts by weight of Radix Astragali, 6 parts by weight of Radix Paeoniae Alba, 12 weight of faenum graecum
Part, 6 parts by weight of dark plum, 13 parts by weight of evodia rutaecarpa, 5 parts by weight of Radix Glycyrrhizae.
Making step:
(1) each raw material are weighed by recipe ratio, rhizoma zingiberis, the tuber of pinellia, Radix Paeoniae Alba, evodia rutaecarpa, Radix Glycyrrhizae crush after with astragalus mongholicus tablet, dark plum
Mixing, puts into the water logging 1h of 10 times of quality, and later, heating and cooking 1h, filtering continuously adds the water of 8 times of quality into filter residue,
Heating and cooking 0.5h, filtering merge filtrate twice, are concentrated into cream liquid concentration in 1:1, obtain primary extract；
(2) ethanol solution of certain mass is added into primary extract under agitation, until ethanol content is after 55%, it is quiet
It sets for 24 hours, is filtered to remove sediment, filtrate volatilizes the ethanol solution that certain mass is added after ethyl alcohol again, until ethanol content exists
After 65%, 48h is stood, sediment is filtered to remove, concentrates the filtrate to cream liquid density after 1.20-1.35, is spray-dried.
2 Radix Astragali of preparation, the preparation of rhizoma zingiberis composite extract
Formula: 30 parts by weight of rhizoma zingiberis, 22 parts by weight of the tuber of pinellia, 9 parts by weight of Radix Astragali, 6 parts by weight of Radix Paeoniae Alba, 12 weight of faenum graecum
Part, 6 parts by weight of dark plum, 13 parts by weight of evodia rutaecarpa, 5 parts by weight of Radix Glycyrrhizae, 1 parts by weight flavone of hawthorn fruit, 1 parts by weight algal polysaccharides.
Making step:
(1) each raw material are weighed by recipe ratio, rhizoma zingiberis, the tuber of pinellia, Radix Paeoniae Alba, evodia rutaecarpa, Radix Glycyrrhizae crush after with astragalus mongholicus tablet, dark plum
Mixing, puts into the water logging 1h of 10 times of quality, and later, heating and cooking 0.5h, filtering continuously adds 8 times of quality into filter residue
Water, heating and cooking 0.5h, filtering merge filtrate twice, are concentrated into cream liquid concentration 1: 1, obtain primary extract；
(2) ethanol solution of certain mass is added into primary extract under agitation, until ethanol content is after 55%, it is quiet
It sets for 24 hours, is filtered to remove sediment, filtrate volatilizes the ethanol solution that certain mass is added after ethyl alcohol again, until ethanol content exists
After 65%, 48h is stood, sediment is filtered to remove, concentrates the filtrate to cream liquid density after 1.20-1.35, is spray-dried；
(3) flavone of hawthorn fruit and algal polysaccharides for putting into recipe ratio, are uniformly mixed.
3 Radix Astragali of preparation, the preparation of rhizoma zingiberis composite extract
Formula: 45 parts by weight of rhizoma zingiberis, 33 parts by weight of the tuber of pinellia, 14 parts by weight of Radix Astragali, 11 parts by weight of Radix Paeoniae Alba, 18 weight of faenum graecum
Part, 7 parts by weight of dark plum, 19 parts by weight of evodia rutaecarpa, 8 parts by weight of Radix Glycyrrhizae.
Making step:
(1) each raw material are weighed by recipe ratio, rhizoma zingiberis, the tuber of pinellia, Radix Paeoniae Alba, evodia rutaecarpa, Radix Glycyrrhizae crush after with astragalus mongholicus tablet, dark plum
Mixing, puts into the water logging 1.5h of 20 times of quality, and later, heating and cooking 1h, filtering continuously adds 5 times of quality into filter residue
Water, heating and cooking 0.5h, filtering merge filtrate twice, are concentrated into cream liquid concentration 1: 2, obtain primary extract；
(2) ethanol solution of certain mass is added into primary extract under agitation, until ethanol content is after 50%, it is quiet
36h is set, is filtered to remove sediment, filtrate volatilizes the ethanol solution that certain mass is added after ethyl alcohol again, until ethanol content exists
It after 75%, stands for 24 hours, is filtered to remove sediment, concentrates the filtrate to cream liquid density after 1.20-1.35, be spray-dried.
4 Radix Astragali of preparation, the preparation of rhizoma zingiberis composite extract
Formula: 40 parts by weight of rhizoma zingiberis, 28 parts by weight of the tuber of pinellia, 12 parts by weight of Radix Astragali, 8 parts by weight of Radix Paeoniae Alba, 15 weight of faenum graecum
Part, 6 parts by weight of dark plum, 17 parts by weight of evodia rutaecarpa, 7 parts by weight of Radix Glycyrrhizae.
Making step:
(1) each raw material are weighed by recipe ratio, rhizoma zingiberis, the tuber of pinellia, Radix Paeoniae Alba, evodia rutaecarpa, Radix Glycyrrhizae crush after with astragalus mongholicus tablet, dark plum
Mixing, puts into the water logging 1h of 15 times of quality, and later, heating and cooking 1h, filtering continuously adds the water of 5 times of quality into filter residue,
Heating and cooking 0.5h, filtering merge filtrate twice, are concentrated into cream liquid concentration 1: 2, obtain primary extract；
(2) ethanol solution of certain mass is added into primary extract under agitation, until ethanol content is after 50%, it is quiet
It sets for 24 hours, is filtered to remove sediment, filtrate volatilizes the ethanol solution that certain mass is added after ethyl alcohol again, until ethanol content exists
After 70%, 48h is stood, sediment is filtered to remove, concentrates the filtrate to cream liquid density after 1.20-1.35, is spray-dried.
Drug effect verifies embodiment:
1, test grouping
Selection parity is close, age in days is identical, " Ternary Pig three way cross " piglet 120 similar in weight, is randomly divided into 4
Processing group, every group of 3 repetitions, each repeating groups totally 10 piglets, according to conventinal breeding management, the piglet of each processing group was from 7 days
Age starts feeding feed, feeds to 21 ages in days and weans after 2 weeks, continues 14 days raising experiments later.Test feeding period
Between, each processing group piglet is raised using group, and piglet is freely eaten and drinking-water, and pig farm is immunized according to normal immunological program, is being tried
It tests before beginning and routine disinfection is carried out to pig farm.
2, test process
Experiment is divided into 4 processing groups, is respectively as follows:
Feed I group: feeding mixed fodder, which is that 0.5% preparation 1 is added in basal feed；
Feed II group: feeding mixed fodder, which is that 1% preparation 1 is added in basal feed；
Feed III group: feeding mixed fodder, which is that 0.5% preparation 2 is added in basal feed；
Feeding IV group: basal feed is only fed；
Feed V group: feeding mixed fodder, the mixed fodder are that addition 0.1mg/kg antibiotic gold is mould in basal feed
Element；
Wherein, basal feed is prepared according to pig nutritional need.Such as following table.
3, growth performance influences data acquisition: the weight of record 21 age in days of piglet is as initial weight, every day entry later
The feed intake of piglet, diarrhea head number, calculate daily gain, feed-weight ratio, diarrhea rate after wean.
Growth Performance of Weaning Piglets influences experimental result and is shown in Table 1.
Specific formula for calculation is as follows:
Daily gain=(weight-initial weight when off-test)/number of days；
Total augment weight weight during test total feed consumption amount/test during feed-weight ratio=test；
Diarrhea rate=(diarrhea head number x Diarrhoea days)/(testing the total head number of total number of days x piglet) x100%
1 Growth Performance of Weaning Piglets statistical form of table
4, Immunity influences data acquisition: 3 days before weaned piglet, 1 day after wean, 4 days, 7 days, 14 days mornings it is same
One period chose weight in each repeating groups close to 3 pigs of this group of average weight, and blood was collected after empty stomach 12h, conventional to make
Standby serum, measure its immune indexes.It the results are shown in Table 2-6.
Table 2: feeding I group weanling pig Immunity statistical form
Table 3: feeding II group weanling pig Immunity statistical form
Table 4: feeding III group weanling pig Immunity statistical form
Table 5: feeding IV group weanling pig Immunity statistical form
Table 6: feeding V group weanling pig Immunity statistical form
As known from Table 1, be respectively added the experimental group (feed I, II, III group) of different amounts of extract produced by the present invention with
Be added without the blank control (feed IV group) of extract or be added antibiotic control group (feeding V group) daily gain, diarrhea rate and
It is compared in terms of three growth performances of feed-weight ratio, each daily gain data that extract group (feeding I, II, III group) is added are all larger than two
Control group, the diarrhea rate data and feed-weight ratio data of each extract group are respectively less than control group, show that the obtained object energy of the present invention is added
The growth performance for enough improving weanling pig, keeps its body weight increase very fast, reduces its diarrhea situation, improve the conversion situation of feed,
And it is more preferable compared with the case where antibiotic is added in feed to improve situation.Wherein, it when preparation 2 is added as additive, increases day by day and brings up again
High larger, diarrhea rate and feed-weight ratio decline are obvious, show a effective amount of flavone of hawthorn fruit and algal polysaccharides and Chinese medical extract
Combination can significantly improve the growing state of weanling pig.
From table 2-6 it is found that in terms of haematogenic immunity globulin, the blank control group (feeding IV group) for being added without extract exists
One day after, the index decline of IgG, IgM, IgA in blood are obvious for weaned piglet, and after wean 2 weeks, remain within one
Compared with lower level before weaning；And the experimental group that different amounts of extract produced by the present invention is respectively added (feeds I, II, III
Group), after weaned piglet one day, the index of IgG, IgM, IgA in blood, which have, slightly to be declined, but content is without significant difference,
After weaning 2 weeks, the level before IgG, IgM content in blood relatively wean has rising, water before the IgA content in blood relatively weans
It puts down to have and slightly decline, still maintain to reduce horizontal phase with IgG, IgM, IgA content of piglet in the nursing V group of addition antibiotic
Than overall effect also increases；Meanwhile within remaining time, haematogenic immunity globulin IgG, IgM, IgA of test group all compared with
Blank control group, antibiotic control group increase, especially.Illustrate that Radix Astragali provided by the invention, rhizoma zingiberis composite extract add
When adding to pig starter feed, piglet immunological globulin content can be improved, and can to significantly improve IgG, IgM in body horizontal, especially
Be the nursing III group for being also added into flavone of hawthorn fruit and algal polysaccharides raising situation it is best, the immunoglobulin in piglet serum
Raising, can protect weanling pig stomach, and then alleviate weaning stress situation.
From table 2-6 it is found that in terms of complement in blood, Complement C_3 of the blank control group (feeding IV group) after wean,
C4 is declined, and especially C3 decline is horizontal higher.The control group of antibiotic is added, the C4 level variation in piglet serum is not
Greatly, though C3 level increases compared with blank group, horizontal decline before the horizontal still relatively wean after wean 2 weeks.It is each that not same amount is added
Radix Astragali produced by the present invention, rhizoma zingiberis composite extract experimental group (feed I, II) in the intraserous Complement C4 level of piglet become
Change less, the relatively wean of C3 level is preceding slightly to be risen, and compared with blank control group and the raising of antibiotic control group after wean 14 days, and is also added
The C3 level in serum after having entered the nursing III group weaned piglet 14 of flavone of hawthorn fruit and algal polysaccharides mentions compared with before wean
High obvious, effect is best.Complement is the main constituents of specific immunity, and the level of complement after weaned piglet in serum increases
Add, illustrate that the immunity function of piglet improves, it was demonstrated that, there is enhancing piglet to exempt from for rhizoma zingiberis that the present invention improves, Radix Astragali composite extract
The effect of epidemic disease power, can alleviate weaning stress of piglet situation.
In conclusion the anti-stress ability of weanling pig can be improved in obtained Radix Astragali provided by the invention, Rhizoma Zingiberis extract,
It reduces diarrhea of the piglet before and after wean, situations such as appetite is low, improves the immunity of piglet, improve the growth feelings of weanling pig
Condition.
Claims (5)
1. a kind of Radix Astragali, rhizoma zingiberis composite extract, which is characterized in that the Radix Astragali, rhizoma zingiberis composite extract according to parts by weight, wrap
Include following component and proportion:
Rhizoma zingiberis 30-45 parts by weight, tuber of pinellia 20-35 parts by weight, Radix Astragali 8-15 parts by weight, Radix Paeoniae Alba 6-12 parts by weight, faenum graecum 10-20
Parts by weight, dark plum 6-8 parts by weight, evodia rutaecarpa 12-20 parts by weight, Radix Glycyrrhizae 5-8 parts by weight.
2. a kind of Radix Astragali according to claim 1, rhizoma zingiberis composite extract, which is characterized in that the Radix Astragali, rhizoma zingiberis are compound to be mentioned
Taking object further includes 1-2 parts by weight flavone of hawthorn fruit and 1-3 parts by weight algal polysaccharides.
3. the preparation method of a kind of Radix Astragali as described in claim 1, rhizoma zingiberis composite extract, which is characterized in that specifically include
Following steps:
(1) each raw material are weighed by recipe ratio, rhizoma zingiberis, the tuber of pinellia, Radix Paeoniae Alba, evodia rutaecarpa, Radix Glycyrrhizae are mixed with astragalus mongholicus tablet, dark plum after crushing
It closes, puts into the water logging 0.5-2h of 10-20 times of quality, later, heating and cooking 0.5-1.5h, filtering is continuously added into filter residue
The water of 5-10 times of quality, heating and cooking 0.5-1h, filtering merge filtrate twice, are concentrated into cream liquid concentration in 1: 1-1: 2 ranges
It is interior, obtain primary extract；
(2) ethanol solution of certain mass is added into primary extract under agitation, until ethanol content is after 50%-60%,
24-48h is stood, is filtered to remove sediment, filtrate volatilizes the ethanol solution that certain mass is added after ethyl alcohol again, until ethanol content
After 60%-80%, 24-48h is stood, sediment is filtered to remove, filtrate is concentrated and dried.
4. the preparation method of a kind of Radix Astragali as described in claim 1, rhizoma zingiberis composite extract, which is characterized in that by recipe ratio
Flavone of hawthorn fruit and algal polysaccharides investment step (2) obtain plant extracts, be uniformly mixed.
5. the application of a kind of Radix Astragali, rhizoma zingiberis composite extract described in claim 1, which is characterized in that press piglet basal feed
The 0.5%-1% dispersion of quality is added into feed, feeding in weanling pig, can be applied to weanling pig stress prevention and treatment, with
The anti-stress ability for improving weanling pig, improves the growing state of weanling pig.
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| CN111011626A (en) * | 2019-12-13 | 2020-04-17 | 安徽省正大源饲料集团有限公司 | Feed additive capable of improving immunity of weaned piglets and preparation method thereof |
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Application publication date: 20190426 |