CN106177737A - Strong tablet containing papaw and preparation method thereof - Google Patents
Strong tablet containing papaw and preparation method thereof Download PDFInfo
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- CN106177737A CN106177737A CN201610756452.1A CN201610756452A CN106177737A CN 106177737 A CN106177737 A CN 106177737A CN 201610756452 A CN201610756452 A CN 201610756452A CN 106177737 A CN106177737 A CN 106177737A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Abstract
The invention discloses a kind of strong tablet containing papaw and preparation method thereof, the strong tablet containing papaw includes the raw material of following parts by weight: papaw 10 50 parts, myrtle fruit 10 30 parts, Fructus Tsaoko 5 30 parts and Semen Ginkgo 5 20 parts.The selected papaw of the present invention, myrtle fruit, Fructus Tsaoko and four kinds of strong medicines of Semen Ginkgo with the use of, produce notable synergism, strong tablet does not contain only the aminoacid of needed by human, electrolytes and minerals, also containing phenols, tannin etc., is possible not only to enhancing immunity and resisting fatigue, can also defying age and anti-malignant tumor, and salivary gland function can be strengthened, ptyalize, strengthen gastrointestinal function, facilitating digestion absorbs, and improves appetite.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, it is more particularly related to a kind of strong tablet containing papaw
Agent and preparation method thereof.
Background technology
Papaw, i.e. Rhamnaceae trifoliate orange, also known as Semen Hoveniae (Fructus Hoveniae), be distributed in Anhui, Zhejiang, Jiangxi, Guangdong, Fujian, Hubei, lake
South, Guangxi, Shaanxi, Sichuan, Guizhou, Yunnan etc. save.Papaw to relaxing muscles and tendons and activating QI and blood in the collateral, refreshment, strong stomach spleen invigorating, reduce blood pressure,
Blood fat, blood are viscous, prophylaxis of cancer, and resisting cancer etc. has well effect, and papaw selenium content is high, is natural rich selenium fruit,
And selenium has the strongest oxidation resistance and anti-cancer and kill cancer action and natural dispelling toxicity, detoxicating effect, can regulate and improve human body
Immunocompetence, maintain the normal configuration of cardiovascular system and function, life lengthening had good effect.
Myrtle fruit, another name: tremble Buddhist nun, hilllock etc., be domestic main product Taiwan, Fujian, Guangdong, Guangxi, Yunnan, Guizhou and
Hunan is the most southern.The ground such as South East Asia Mainland, Philippine, Japan, India, Sri Lanka, Malaysia and Indonesia also have point
Cloth.Myrtle fruit contains phenols, tannin etc., controls chronic dysentery, rheumatism, hepatitis and the effect such as blood fat reducing, astringing to arrest bleeding, mainly uses
, haematemesis, epistaxis, impairment caused by overstrain hemoptysis weak in: nourishing blood and hemoslasis, astringing intestine to stop diarrhea controlling nocturnal emission with astringent drugs, main blood deficiency, have blood in stool, metrorrhagia, dysentery, proctoptosis, scald,
Traumatic hemorrhage etc..
Fructus Tsaoko, is grown in area in the woods of the torrid zone, semi-tropical concealment humidity, with Chinese yunnan, Guangxi, Guizhou and other places is
Mainly it is distributed ground.Artificial culture is based on Yunnan.Yunnan Province of China is the main place of production of Fructus Tsaoko, the most history of more than 200 year.
Fructus Tsaoko has special fragrance, acrid in the mouth, micro-hardship, is a kind of flavoring, has special strong pungent fragrance.Its fruit quilt being dried
As Chinese meal flavouring agent and Chinese herbal medicine.Being one of large kind of Chinese herbal medicines, amount is more than survival dose.Fructus Tsaoko has
Drying damp and strengthening spleen, the function of expectorant preventing the attack (or recurrence) of malaria.Cure mainly distension and fullness in the abdomen, the diseases such as regurgitation is vomitted, food stagnation malaria.A lot of Chinese patent medicines be unable to do without it
Formula, search wind ball, Yishen Pills, dissipating depression of QI SHUGAN WAN, the chest stuffiness relieving profit diaphragm ball, JIEBAI WAN etc. as deep.Along with people's living standard
Improving and healthy needs, the purposes of Fructus Tsaoko and consumption are by increasing the most.
Semen Ginkgo, main product in Jiangsu, Guangxi, Sichuan, Henan, Shandong, the ground such as Hubei, Semen Ginkgo kernel is except containing starch, albumen
Outside matter, fat, saccharide, possibly together with trace element and silver such as vitamin C, riboflavin, carotene, calcium, phosphorus, ferrum, potassium, magnesium
Fructus Pruni acid, bilobol, five carbon polysaccharide, the composition such as fat sterin, nutritious, and for lung benefiting gas, control cough with asthma, leukorrhagia stopping worm, reduce
Just, flat chapped wrinkle, protect blood vessel, increase the diseases such as blood flow, leukorrhagia, nebulousurine there is good medical effect and dietary function.
Along with the development of society, the life of people is no longer the theme to have enough to eat and wear, and health care consciousness constantly strengthens, life
Quality becomes concerned emphasis already, and social senilization's problem of China is day by day serious at present, and people are to health
The requirement of quality of life more and more higher, pursue health, pursue longevity, slow down aging has become as emphasis of concern and asks
Topic.And modern life rhythm is fast, people are difficult to take out the time of abundance and perform physical exercise, and a lot of people have taken resisting fatigue, strengthened and exempt from
Epidemic disease power, the health care medicine of deferring senility, to reach the purpose of good health and a long life.The existing resisting fatigue of existing market, enhancing are exempted from
Epidemic disease power, slow down aging health product of a great variety, breed difference is big, is not particularly suited for all groups.
Summary of the invention
It is an object of the invention to solve at least the above, and the advantage that at least will be described later is provided.
It is a still further object of the present invention to provide a kind of strong tablet containing papaw, by papaw, myrtle fruit, Fructus Tsaoko
With four kinds of strong medicines of Semen Ginkgo with the use of, produce notable synergism, it is raw that strong tablet does not contain only the aminoacid of needed by human, dimension
Element and trace element, also containing phenols, tannin etc., be possible not only to enhancing immunity and resisting fatigue, moreover it is possible to defying age and anti-pernicious
Tumor, and salivary gland function can be strengthened, to ptyalize, strengthen gastrointestinal function, facilitating digestion absorbs, and improves food
It is intended to.The effective ingredient of the strong tablet containing Rhizoma Smilacis Scobinicaulis that the present invention provides is strong medicament extract, is suitable for all groups, without any
Side effect.
It is a still further object of the present invention to provide the preparation method of a kind of strong tablet containing papaw, utilize composite bacteria
After papaw, myrtle fruit and Semen Ginkgo are fermented, re-use compound enzyme and it is carried out enzymolysis, obtain papaw, Fructus Rhodomyrti
Fruit and the extract of Semen Ginkgo, prepare Fructus Tsaoko extract by supercritical carbon dioxide extraction, then absorb Fructus Tsaoko extraction with diluent
Take thing, then mix with the extract of papaw, myrtle fruit and Semen Ginkgo and diluent, binding agent, flavoring agent, be eventually adding profit
Lubrication prescription mix homogeneously, prepares tablet, and the preparation method of the present invention improves the extraction of papaw, myrtle fruit, Fructus Tsaoko and Semen Ginkgo
Rate and the purity of extract, allow four Chinese medicines interpenetrate absorption of mutually promoting, and improve stable effective ingredients, fully send out
Wave pharmacological action so that the strong tablet containing papaw that the present invention produces passes through Mutiple Targets multipath synergistic mechanism, actively
Improve organismic internal environment and functional status.
In order to realize according to object of the present invention and further advantage, it is provided that a kind of strong tablet containing papaw, bag
Include the raw material of following parts by weight:
Papaw 10-50 part, myrtle fruit 10-30 part, Fructus Tsaoko 10-30 part and Semen Ginkgo 10-30 part.
The preparation method of a kind of strong tablet containing papaw, comprises the following steps:
Step one, by the papaw of 10-50 weight portion, the myrtle fruit of 10-30 weight portion and the Semen Ginkgo of 10-30 weight portion
After rinsing well with clear water respectively, dry to constant weight, pulverize, and cross 60-100 mesh sieve, prepare papaw powder, Fructus Rhodomyrti fruit powder
End and Semen Ginkgo powder；After papaw powder, myrtle fruit powder and Semen Ginkgo powder mix homogeneously, it is immersed in containing whiterot fungi, difference
In the water of 1-Hydroxy-1,2,3-propanetricarboxylic acid. bacillus and Lactobacillus plantarum, temperature be 30-40 DEG C, air humidity be 70-80% bottom fermentation 48-50h
After, water is evaporated, is milled into powder by being evaporated prepared solid afterwards, prepare the first mixed-powder, standby；
Step 2, the Fructus Tsaoko clear water of 10-30 weight portion is rinsed well after, be dried to constant weight, pulverize, and cross 60-100
After mesh sieve, extraction temperature be 40-50 DEG C, extracting pressure is 15-25MPa and carbon dioxide flow is to carry out under 80-100L/h
After supercritical carbon dioxide extraction 2-3h, prepare Fructus Tsaoko extract, standby；
Step 3, by the lysozyme of 2-10 weight portion, the lywallzyme of 10-30 weight portion, the cellulase of 1-3 weight portion,
The hemicellulase of 1-3 weight portion, the pectase of 3-5 weight portion, the ligninase of 1-2 weight portion and the glucose of 1-2 weight portion
Glycosides enzyme adds in the water of 1000-2000 weight portion, after preparing complex enzyme liquid, the first mixed-powder prepared is added in step one
In complex enzyme liquid, after mix homogeneously, with edible organic acid regulation pH value to 4-5, enzymolysis 3-4h at 40-60 DEG C afterwards, prepare
Enzymolysis solution, standby；
Step 4, the enzymolysis solution filtration that will prepare in step 3, prepare the first filtering residue and the first filtrate, used by the first filtering residue
The clear water of 50-60 weight portion rinses 2-3 time, prepares the second filtering residue, collects simultaneously and rinse the washings obtained every time, by collect
Washings and the first filtrate mix homogeneously, prepare the first mixed liquor, the first mixed liquor be incubated at 90-100 DEG C 20-30min,
After carrying out enzyme denaturing process, prepare the second mixed liquor, standby；
Step 5, by step 4 prepare second filtering residue add 50-60 weight portion the second that volume parts is 70-80%
In alcohol-water solution, after being heated to reflux 45-55min, filter, prepare the second filtrate, the will prepared in the second filtrate and step 4
After two mixed liquor mix homogeneously, temperature be 45-65 DEG C, pressure be to be concentrated in vacuo under 80-90KPa, be then spray-dried, prepare
Second mixed-powder, standby；
Step 6, by two parts of the quality such as the diluent of 10-50 weight portion is divided into, will step 2 prepare Fructus Tsaoko extraction
Thing is milled into powder after mixing homogeneously with a diluent, prepares the 3rd mixed-powder；The second mixing that will prepare in step 5
Powder, the 3rd mixed-powder, another portion of diluent, the binding agent of 2-5 weight portion, the disintegrating agent of 1-3 weight portion, and 1-2 weight
The flavoring agent mix homogeneously of amount part, prepares the 4th mixed-powder, then adds the lubrication of 0.5-2 weight portion in the 4th mixed-powder
Mix homogeneously after agent, prepares the 5th mixed-powder, standby；
Step 7, the 5th mixed-powder prepared in step 6 is carried out tabletting, obtain the described strong tablet containing papaw
Agent.
Preferably, in the preparation method of the described strong tablet containing papaw, whiterot fungi, difference in described step one
Citric acid bacillus and the Lactobacillus plantarum initial clump count in water be respectively 300-600CFU/mL, 500-1000CFU/mL and
200-500CFU/mL。
Preferably, in the preparation method of the described strong tablet containing papaw, described edible organic acid is phytic acid, lemon
Any one or a few in lemon acid, malic acid and tartaric acid.
Preferably, in the preparation method of the described strong tablet containing papaw, described diluent is by amylum pregelatinisatum
Mix for 2:1 in mass ratio with microcrystalline Cellulose.
Preferably, in the preparation method of the described strong tablet containing papaw, described binding agent is by hydroxy propyl cellulose
Element, hypromellose and polyvidone mix for 2:2:1 in mass ratio.
Preferably, in the preparation method of the described strong tablet containing papaw, described lubricant by magnesium stearate and
Micropowder silica gel mixes for 3:2 in mass ratio.
Preferably, in the preparation method of the described strong tablet containing papaw, described flavoring agent is sorbitol, manna
Any one or a few in alcohol or synthetic sweetener saccharin sodium.
The present invention at least includes following beneficial effect:
The selected papaw of strong tablet containing papaw, myrtle fruit, Fructus Tsaoko and four kinds of strong medicines of Semen Ginkgo that the present invention provides
With the use of, producing notable synergism, strong tablet does not contain only the aminoacid of needed by human, electrolytes and minerals,
Also containing phenols, tannin etc., it is possible not only to enhancing immunity and resisting fatigue, moreover it is possible to defying age and anti-malignant tumor, and can
Strengthening salivary gland function, ptyalize, strengthen gastrointestinal function, facilitating digestion absorbs, and improves appetite.
The effective ingredient of the strong tablet containing Rhizoma Smilacis Scobinicaulis that the present invention provides is strong medicament extract, is suitable for all groups,
Without any side effects.
The present invention uses whiterot fungi, difference citric acid bacillus and Lactobacillus plantarum to papaw, Fructus Persicae gold in preparation process
Ma fruit and Semen Ginkgo carry out fermentation process so that it is Chinese medicine ingredients converts through probiotic bacteria, macromole become little molecule, 100% quilt
Absorption of human body so that curative effect speed-raising, drug effect improve.
The present invention uses supercritical carbon dioxide extraction to prepare Fructus Tsaoko extract in preparation process, and extraction yield is high, prepares
Fructus Tsaoko extract purity high.
Part is embodied by the further advantage of the present invention, target and feature by description below, and part also will be by this
Invention research and practice and be understood by the person skilled in the art.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, to make those skilled in the art with reference to description
Word can be implemented according to this.
<embodiment 1>
A kind of strong tablet containing papaw, including the raw material of following parts by weight:
Papaw 10 parts, myrtle fruit 10 parts, Fructus Tsaoko 10 parts and Semen Ginkgo 10 parts.
The preparation method of a kind of strong tablet containing papaw, comprises the following steps:
Step one, by the Semen Ginkgo of the papaw of 10 weight portions, the myrtle fruit of 10 weight portions and 10 weight portions respectively with clear
After water is rinsed well, dry to constant weight, pulverize, and cross 80 mesh sieves, prepare papaw powder, myrtle fruit powder and Semen Ginkgo powder
End；After papaw powder, myrtle fruit powder and Semen Ginkgo powder mix homogeneously, it is immersed in containing whiterot fungi, difference citric acid bar
In the water of bacterium and Lactobacillus plantarum, it is 35 DEG C in temperature, after air humidity is 75% bottom fermentation 48h, water is evaporated, will steam afterwards
The drying solid obtained is milled into powder, prepares the first mixed-powder, standby；
Step 2, the Fructus Tsaoko clear water of 10 weight portions is rinsed well after, be dried to constant weight, pulverize, and after crossing 80 mesh sieves,
Extraction temperature be 45 DEG C, extracting pressure is 20MPa and carbon dioxide flow is to carry out supercritical carbon dioxide extraction under 80L/h
After 2h, prepare Fructus Tsaoko extract, standby；
Step 3, by the lysozyme of 5 weight portions, the lywallzyme of 20 weight portions, the cellulase of 2 weight portions, 3 weight portions
The glucosidase of hemicellulase, the pectase of 4 weight portions, the ligninase of 2 weight portions and 1 weight portion adds 1000 weight portions
Water in, prepare after complex enzyme liquid, the first mixed-powder that will prepare in step one adds in complex enzyme liquid, after mix homogeneously,
With edible organic acid regulation pH value to 5, enzymolysis 3-4h at 45 DEG C afterwards, prepare enzymolysis solution, standby；
Step 4, the enzymolysis solution filtration that will prepare in step 3, prepare the first filtering residue and the first filtrate, used by the first filtering residue
The clear water of 50 weight portions rinses 3 times, prepares the second filtering residue, collects simultaneously and rinse the washings obtained every time, the washing that will collect
Water and the first filtrate mix homogeneously, prepare the first mixed liquor, the first mixed liquor be incubated at 90 DEG C 30min, carry out at enzyme denaturing
After reason, prepare the second mixed liquor, standby；
Step 5, that the second filtering residue prepared in step 4 is added the ethanol that volume parts is 70% of 50 weight portions is water-soluble
In liquid, after being heated to reflux 50min, filter, prepare the second filtrate, the second mixed liquor prepared in the second filtrate and step 4 is mixed
After closing uniformly, temperature be 55 DEG C, pressure be to be concentrated in vacuo under 80KPa, be then spray-dried, prepare the second mixed-powder, standby
With；
Step 6, by two parts of the quality such as the diluent of 50 weight portions is divided into, the Fructus Tsaoko extract that will prepare in step 2
It is milled into powder after mixing homogeneously with a diluent, prepares the 3rd mixed-powder；The second mixed powder that will prepare in step 5
End, the 3rd mixed-powder, another portion of diluent, the binding agent of 3 weight portions, the disintegrating agent of 2 weight portions, and the tune of 2 weight portions
Taste agent mix homogeneously, prepares the 4th mixed-powder, then adds after the lubricant of 1.5 weight portions mixing in the 4th mixed-powder all
Even, prepare the 5th mixed-powder, standby；
Step 7, the 5th mixed-powder prepared in step 6 is carried out tabletting, obtain the described strong tablet containing papaw
Agent.
In the preparation method of the described strong tablet containing papaw, it is characterised in that whiterot fungi, difference in described step one
1-Hydroxy-1,2,3-propanetricarboxylic acid. bacillus and the Lactobacillus plantarum initial clump count in water is respectively 400CFU/mL, 600CFU/mL and 300CFU/
mL。
In the preparation method of the described strong tablet containing papaw, described edible organic acid is phytic acid.
In the preparation method of the described strong tablet containing papaw, described diluent is by amylum pregelatinisatum and microcrystalline cellulose
Element mixes for 2:1 in mass ratio.
In the preparation method of the described strong tablet containing papaw, described binding agent is by hydroxypropyl cellulose, hydroxypropyl first
Cellulose and polyvidone mix for 2:2:1 in mass ratio.
In the preparation method of the described strong tablet containing papaw, described lubricant is pressed by magnesium stearate and micropowder silica gel
Mass ratio is that 3:2 mixes.
In the preparation method of the described strong tablet containing papaw, described flavoring agent is sorbitol.
<embodiment 2>
A kind of strong tablet containing papaw, including the raw material of following parts by weight:
Papaw 30 parts, myrtle fruit 20 parts, Fructus Tsaoko 20 parts and Semen Ginkgo 20 parts.
The preparation method of a kind of strong tablet containing papaw, comprises the following steps:
Step one, by the Semen Ginkgo of the papaw of 30 weight portions, the myrtle fruit of 20 weight portions and 20 weight portions respectively with clear
After water is rinsed well, dry to constant weight, pulverize, and cross 80 mesh sieves, prepare papaw powder, myrtle fruit powder and Semen Ginkgo powder
End；After papaw powder, myrtle fruit powder and Semen Ginkgo powder mix homogeneously, it is immersed in containing whiterot fungi, difference citric acid bar
In the water of bacterium and Lactobacillus plantarum, it is 35 DEG C in temperature, after air humidity is 75% bottom fermentation 48h, water is evaporated, will steam afterwards
The drying solid obtained is milled into powder, prepares the first mixed-powder, standby；
Step 2, the Fructus Tsaoko clear water of 20 weight portions is rinsed well after, be dried to constant weight, pulverize, and after crossing 80 mesh sieves,
Extraction temperature be 45 DEG C, extracting pressure is 20MPa and carbon dioxide flow is to carry out supercritical carbon dioxide extraction under 80L/h
After 2h, prepare Fructus Tsaoko extract, standby；
Step 3, by the lysozyme of 5 weight portions, the lywallzyme of 20 weight portions, the cellulase of 2 weight portions, 3 weight portions
The glucosidase of hemicellulase, the pectase of 4 weight portions, the ligninase of 2 weight portions and 1 weight portion adds 1000 weight portions
Water in, prepare after complex enzyme liquid, the first mixed-powder that will prepare in step one adds in complex enzyme liquid, after mix homogeneously,
With edible organic acid regulation pH value to 5, enzymolysis 3-4h at 45 DEG C afterwards, prepare enzymolysis solution, standby；
Step 4, the enzymolysis solution filtration that will prepare in step 3, prepare the first filtering residue and the first filtrate, used by the first filtering residue
The clear water of 50 weight portions rinses 3 times, prepares the second filtering residue, collects simultaneously and rinse the washings obtained every time, the washing that will collect
Water and the first filtrate mix homogeneously, prepare the first mixed liquor, the first mixed liquor be incubated at 90 DEG C 30min, carry out at enzyme denaturing
After reason, prepare the second mixed liquor, standby；
Step 5, that the second filtering residue prepared in step 4 is added the ethanol that volume parts is 70% of 50 weight portions is water-soluble
In liquid, after being heated to reflux 50min, filter, prepare the second filtrate, the second mixed liquor prepared in the second filtrate and step 4 is mixed
After closing uniformly, temperature be 55 DEG C, pressure be to be concentrated in vacuo under 80KPa, be then spray-dried, prepare the second mixed-powder, standby
With；
Step 6, by two parts of the quality such as the diluent of 50 weight portions is divided into, the Fructus Tsaoko extract that will prepare in step 2
It is milled into powder after mixing homogeneously with a diluent, prepares the 3rd mixed-powder；The second mixed powder that will prepare in step 5
End, the 3rd mixed-powder, another portion of diluent, the binding agent of 3 weight portions, the disintegrating agent of 2 weight portions, and the tune of 2 weight portions
Taste agent mix homogeneously, prepares the 4th mixed-powder, then adds after the lubricant of 1.5 weight portions mixing in the 4th mixed-powder all
Even, prepare the 5th mixed-powder, standby；
Step 7, the 5th mixed-powder prepared in step 6 is carried out tabletting, obtain the described strong tablet containing papaw
Agent.
In the preparation method of the described strong tablet containing papaw, whiterot fungi, difference citric acid bar in described step one
Bacterium and the Lactobacillus plantarum initial clump count in water is respectively 400CFU/mL, 600CFU/mL and 300CFU/mL.
In the preparation method of the described strong tablet containing papaw, described edible organic acid is malic acid.
In the preparation method of the described strong tablet containing papaw, described diluent is by amylum pregelatinisatum and microcrystalline cellulose
Element mixes for 2:1 in mass ratio.
In the preparation method of the described strong tablet containing papaw, described binding agent is by hydroxypropyl cellulose, hydroxypropyl first
Cellulose and polyvidone mix for 2:2:1 in mass ratio.
In the preparation method of the described strong tablet containing papaw, described lubricant is pressed by magnesium stearate and micropowder silica gel
Mass ratio is that 3:2 mixes.
In the preparation method of the described strong tablet containing papaw, described flavoring agent is mannitol.
<embodiment 3>
A kind of strong tablet containing papaw, including the raw material of following parts by weight:
Papaw 50 parts, myrtle fruit 30 parts, Fructus Tsaoko 30 parts and Semen Ginkgo 30 parts.
The preparation method of a kind of strong tablet containing papaw, comprises the following steps:
Step one, by the Semen Ginkgo of the papaw of 50 weight portions, the myrtle fruit of 30 weight portions and 30 weight portions respectively with clear
After water is rinsed well, dry to constant weight, pulverize, and cross 80 mesh sieves, prepare papaw powder, myrtle fruit powder and Semen Ginkgo powder
End；After papaw powder, myrtle fruit powder and Semen Ginkgo powder mix homogeneously, it is immersed in containing whiterot fungi, difference citric acid bar
In the water of bacterium and Lactobacillus plantarum, it is 35 DEG C in temperature, after air humidity is 75% bottom fermentation 48h, water is evaporated, will steam afterwards
The drying solid obtained is milled into powder, prepares the first mixed-powder, standby；
Step 2, the Fructus Tsaoko clear water of 30 weight portions is rinsed well after, be dried to constant weight, pulverize, and after crossing 80 mesh sieves,
Extraction temperature be 45 DEG C, extracting pressure is 20MPa and carbon dioxide flow is to carry out supercritical carbon dioxide extraction under 80L/h
After 2h, prepare Fructus Tsaoko extract, standby；
Step 3, by the lysozyme of 5 weight portions, the lywallzyme of 20 weight portions, the cellulase of 2 weight portions, 3 weight portions
The glucosidase of hemicellulase, the pectase of 4 weight portions, the ligninase of 2 weight portions and 1 weight portion adds 1000 weight portions
Water in, prepare after complex enzyme liquid, the first mixed-powder that will prepare in step one adds in complex enzyme liquid, after mix homogeneously,
With edible organic acid regulation pH value to 5, enzymolysis 3-4h at 45 DEG C afterwards, prepare enzymolysis solution, standby；
Step 4, the enzymolysis solution filtration that will prepare in step 3, prepare the first filtering residue and the first filtrate, used by the first filtering residue
The clear water of 50 weight portions rinses 3 times, prepares the second filtering residue, collects simultaneously and rinse the washings obtained every time, the washing that will collect
Water and the first filtrate mix homogeneously, prepare the first mixed liquor, the first mixed liquor be incubated at 90 DEG C 30min, carry out at enzyme denaturing
After reason, prepare the second mixed liquor, standby；
Step 5, that the second filtering residue prepared in step 4 is added the ethanol that volume parts is 70% of 50 weight portions is water-soluble
In liquid, after being heated to reflux 50min, filter, prepare the second filtrate, the second mixed liquor prepared in the second filtrate and step 4 is mixed
After closing uniformly, temperature be 55 DEG C, pressure be to be concentrated in vacuo under 80KPa, be then spray-dried, prepare the second mixed-powder, standby
With；
Step 6, by two parts of the quality such as the diluent of 50 weight portions is divided into, the Fructus Tsaoko extract that will prepare in step 2
It is milled into powder after mixing homogeneously with a diluent, prepares the 3rd mixed-powder；The second mixed powder that will prepare in step 5
End, the 3rd mixed-powder, another portion of diluent, the binding agent of 3 weight portions, the disintegrating agent of 2 weight portions, and the tune of 2 weight portions
Taste agent mix homogeneously, prepares the 4th mixed-powder, then adds after the lubricant of 1.5 weight portions mixing in the 4th mixed-powder all
Even, prepare the 5th mixed-powder, standby；
Step 7, the 5th mixed-powder prepared in step 6 is carried out tabletting, obtain the described strong tablet containing papaw
Agent.
In the preparation method of the described strong tablet containing papaw, whiterot fungi, difference citric acid bar in described step one
Bacterium and the Lactobacillus plantarum initial clump count in water is respectively 400CFU/mL, 600CFU/mL and 300CFU/mL.
In the preparation method of the described strong tablet containing papaw, described edible organic acid is tartaric acid.
In the preparation method of the described strong tablet containing papaw, described diluent is by amylum pregelatinisatum and microcrystalline cellulose
Element mixes for 2:1 in mass ratio.
In the preparation method of the described strong tablet containing papaw, described binding agent is by hydroxypropyl cellulose, hydroxypropyl first
Cellulose and polyvidone mix for 2:2:1 in mass ratio.
In the preparation method of the described strong tablet containing papaw, described lubricant is pressed by magnesium stearate and micropowder silica gel
Mass ratio is that 3:2 mixes.
In the preparation method of the described strong tablet containing papaw, described flavoring agent is synthetic sweetener saccharin sodium.
<comparative example 1>
A kind of strong tablet, including the raw material of following parts by weight:
Myrtle fruit 30 parts, Fructus Tsaoko 30 parts and Semen Ginkgo 30 parts.
The preparation method of a kind of strong tablet, comprises the following steps:
Step one, the myrtle fruit of 30 weight portions and the Semen Ginkgo of 30 weight portions are rinsed well with clear water respectively after, dry
To constant weight, pulverize, and cross 80 mesh sieves, prepare myrtle fruit powder and Semen Ginkgo powder；Myrtle fruit powder and Semen Ginkgo powder are mixed
After closing uniformly, be immersed in the water containing whiterot fungi, difference citric acid bacillus and Lactobacillus plantarum, temperature be 35 DEG C, air wet
After degree is 75% bottom fermentation 48h, water is evaporated, is milled into powder by being evaporated prepared solid afterwards, prepare the first mixed-powder,
Standby；
Step 2, the Fructus Tsaoko clear water of 30 weight portions is rinsed well after, be dried to constant weight, pulverize, and after crossing 80 mesh sieves,
Extraction temperature be 45 DEG C, extracting pressure is 20MPa and carbon dioxide flow is to carry out supercritical carbon dioxide extraction under 80L/h
After 2h, prepare Fructus Tsaoko extract, standby；
Step 3, by the lysozyme of 5 weight portions, the lywallzyme of 20 weight portions, the cellulase of 2 weight portions, 3 weight portions
The glucosidase of hemicellulase, the pectase of 4 weight portions, the ligninase of 2 weight portions and 1 weight portion adds 1000 weight portions
Water in, prepare after complex enzyme liquid, the first mixed-powder that will prepare in step one adds in complex enzyme liquid, after mix homogeneously,
With edible organic acid regulation pH value to 5, enzymolysis 3-4h at 45 DEG C afterwards, prepare enzymolysis solution, standby；
Step 4, the enzymolysis solution filtration that will prepare in step 3, prepare the first filtering residue and the first filtrate, used by the first filtering residue
The clear water of 50 weight portions rinses 3 times, prepares the second filtering residue, collects simultaneously and rinse the washings obtained every time, the washing that will collect
Water and the first filtrate mix homogeneously, prepare the first mixed liquor, the first mixed liquor be incubated at 90 DEG C 30min, carry out at enzyme denaturing
After reason, prepare the second mixed liquor, standby；
Step 5, that the second filtering residue prepared in step 4 is added the ethanol that volume parts is 70% of 50 weight portions is water-soluble
In liquid, after being heated to reflux 50min, filter, prepare the second filtrate, the second mixed liquor prepared in the second filtrate and step 4 is mixed
After closing uniformly, temperature be 55 DEG C, pressure be to be concentrated in vacuo under 80KPa, be then spray-dried, prepare the second mixed-powder, standby
With；
Step 6, by two parts of the quality such as the diluent of 50 weight portions is divided into, the Fructus Tsaoko extract that will prepare in step 2
It is milled into powder after mixing homogeneously with a diluent, prepares the 3rd mixed-powder；The second mixed powder that will prepare in step 5
End, the 3rd mixed-powder, another portion of diluent, the binding agent of 3 weight portions, the disintegrating agent of 2 weight portions, and the tune of 2 weight portions
Taste agent mix homogeneously, prepares the 4th mixed-powder, then adds after the lubricant of 1.5 weight portions mixing in the 4th mixed-powder all
Even, prepare the 5th mixed-powder, standby；
Step 7, the 5th mixed-powder prepared in step 6 is carried out tabletting, obtain the described strong tablet containing papaw
Agent.
In the preparation method of described strong tablet, whiterot fungi, difference citric acid bacillus and plant breast in described step one
The bacillus initial clump count in water is respectively 400CFU/mL, 600CFU/mL and 300CFU/mL.
In the preparation method of described strong tablet, described edible organic acid is tartaric acid.
In the preparation method of described strong tablet, described diluent is by amylum pregelatinisatum and microcrystalline Cellulose in mass ratio
Mix for 2:1.
In the preparation method of described strong tablet, described binding agent is by hydroxypropyl cellulose, hypromellose and gathers
Dimension ketone mixes for 2:2:1 in mass ratio.
In the preparation method of described strong tablet, described lubricant is 3 by magnesium stearate and micropowder silica gel in mass ratio:
2 mix.
In the preparation method of described strong tablet, described flavoring agent is synthetic sweetener saccharin sodium.
<comparative example 2>
A kind of strong tablet containing papaw, including the raw material of following parts by weight:
Papaw 30 parts, Fructus Tsaoko 20 parts and Semen Ginkgo 20 parts.
The preparation method of a kind of strong tablet containing papaw, comprises the following steps:
Step one, the papaw of 30 weight portions and the Semen Ginkgo of 20 weight portions are rinsed well with clear water respectively after, dry extremely
Constant weight, pulverizes, and crosses 80 mesh sieves, prepares papaw powder and Semen Ginkgo powder；By papaw powder and Semen Ginkgo powder mix homogeneously
After, be immersed in the water containing whiterot fungi, difference citric acid bacillus and Lactobacillus plantarum, temperature be 35 DEG C, air humidity be
After 75% bottom fermentation 48h, water is evaporated, is milled into powder by being evaporated prepared solid afterwards, prepare the first mixed-powder, standby
With；
Step 2, the Fructus Tsaoko clear water of 20 weight portions is rinsed well after, be dried to constant weight, pulverize, and after crossing 80 mesh sieves,
Extraction temperature be 45 DEG C, extracting pressure is 20MPa and carbon dioxide flow is to carry out supercritical carbon dioxide extraction under 80L/h
After 2h, prepare Fructus Tsaoko extract, standby；
Step 3, by the lysozyme of 5 weight portions, the lywallzyme of 20 weight portions, the cellulase of 2 weight portions, 3 weight portions
The glucosidase of hemicellulase, the pectase of 4 weight portions, the ligninase of 2 weight portions and 1 weight portion adds 1000 weight portions
Water in, prepare after complex enzyme liquid, the first mixed-powder that will prepare in step one adds in complex enzyme liquid, after mix homogeneously,
With edible organic acid regulation pH value to 5, enzymolysis 3-4h at 45 DEG C afterwards, prepare enzymolysis solution, standby；
Step 4, the enzymolysis solution filtration that will prepare in step 3, prepare the first filtering residue and the first filtrate, used by the first filtering residue
The clear water of 50 weight portions rinses 3 times, prepares the second filtering residue, collects simultaneously and rinse the washings obtained every time, the washing that will collect
Water and the first filtrate mix homogeneously, prepare the first mixed liquor, the first mixed liquor be incubated at 90 DEG C 30min, carry out at enzyme denaturing
After reason, prepare the second mixed liquor, standby；
Step 5, that the second filtering residue prepared in step 4 is added the ethanol that volume parts is 70% of 50 weight portions is water-soluble
In liquid, after being heated to reflux 50min, filter, prepare the second filtrate, the second mixed liquor prepared in the second filtrate and step 4 is mixed
After closing uniformly, temperature be 55 DEG C, pressure be to be concentrated in vacuo under 80KPa, be then spray-dried, prepare the second mixed-powder, standby
With；
Step 6, by two parts of the quality such as the diluent of 50 weight portions is divided into, the Fructus Tsaoko extract that will prepare in step 2
It is milled into powder after mixing homogeneously with a diluent, prepares the 3rd mixed-powder；The second mixed powder that will prepare in step 5
End, the 3rd mixed-powder, another portion of diluent, the binding agent of 3 weight portions, the disintegrating agent of 2 weight portions, and the tune of 2 weight portions
Taste agent mix homogeneously, prepares the 4th mixed-powder, then adds after the lubricant of 1.5 weight portions mixing in the 4th mixed-powder all
Even, prepare the 5th mixed-powder, standby；
Step 7, the 5th mixed-powder prepared in step 6 is carried out tabletting, obtain the described strong tablet containing papaw
Agent.
In the preparation method of the described strong tablet containing papaw, whiterot fungi, difference citric acid bar in described step one
Bacterium and the Lactobacillus plantarum initial clump count in water is respectively 400CFU/mL, 600CFU/mL and 300CFU/mL.
In the preparation method of the described strong tablet containing papaw, described edible organic acid is malic acid.
In the preparation method of the described strong tablet containing papaw, described diluent is by amylum pregelatinisatum and microcrystalline cellulose
Element mixes for 2:1 in mass ratio.
In the preparation method of the described strong tablet containing papaw, described binding agent is by hydroxypropyl cellulose, hydroxypropyl first
Cellulose and polyvidone mix for 2:2:1 in mass ratio.
In the preparation method of the described strong tablet containing papaw, described lubricant is pressed by magnesium stearate and micropowder silica gel
Mass ratio is that 3:2 mixes.
In the preparation method of the described strong tablet containing papaw, described flavoring agent is mannitol.
<comparative example 3>
A kind of strong tablet, including the raw material of following parts by weight:
Fructus Tsaoko 10 parts and Semen Ginkgo 10 parts.
The preparation method of a kind of strong tablet, comprises the following steps:
Step one, the Semen Ginkgo of 10 weight portions is rinsed well with clear water after, dry to constant weight, pulverize, and cross 80 mesh sieves, system
Obtain Semen Ginkgo powder；Semen Ginkgo powder is immersed in the water containing whiterot fungi, difference citric acid bacillus and Lactobacillus plantarum, in temperature is
35 DEG C, after air humidity is 75% bottom fermentation 48h, water is evaporated, is milled into powder by being evaporated prepared solid afterwards, prepare the
One mixed-powder, standby；
Step 2, the Fructus Tsaoko clear water of 10 weight portions is rinsed well after, be dried to constant weight, pulverize, and after crossing 80 mesh sieves,
Extraction temperature be 45 DEG C, extracting pressure is 20MPa and carbon dioxide flow is to carry out supercritical carbon dioxide extraction under 80L/h
After 2h, prepare Fructus Tsaoko extract, standby；
Step 3, by the lysozyme of 5 weight portions, the lywallzyme of 20 weight portions, the cellulase of 2 weight portions, 3 weight portions
The glucosidase of hemicellulase, the pectase of 4 weight portions, the ligninase of 2 weight portions and 1 weight portion adds 1000 weight portions
Water in, prepare after complex enzyme liquid, the first mixed-powder that will prepare in step one adds in complex enzyme liquid, after mix homogeneously,
With edible organic acid regulation pH value to 5, enzymolysis 3-4h at 45 DEG C afterwards, prepare enzymolysis solution, standby；
Step 4, the enzymolysis solution filtration that will prepare in step 3, prepare the first filtering residue and the first filtrate, used by the first filtering residue
The clear water of 50 weight portions rinses 3 times, prepares the second filtering residue, collects simultaneously and rinse the washings obtained every time, the washing that will collect
Water and the first filtrate mix homogeneously, prepare the first mixed liquor, the first mixed liquor be incubated at 90 DEG C 30min, carry out at enzyme denaturing
After reason, prepare the second mixed liquor, standby；
Step 5, that the second filtering residue prepared in step 4 is added the ethanol that volume parts is 70% of 50 weight portions is water-soluble
In liquid, after being heated to reflux 50min, filter, prepare the second filtrate, the second mixed liquor prepared in the second filtrate and step 4 is mixed
After closing uniformly, temperature be 55 DEG C, pressure be to be concentrated in vacuo under 80KPa, be then spray-dried, prepare the second mixed-powder, standby
With；
Step 6, by two parts of the quality such as the diluent of 50 weight portions is divided into, the Fructus Tsaoko extract that will prepare in step 2
It is milled into powder after mixing homogeneously with a diluent, prepares the 3rd mixed-powder；The second mixed powder that will prepare in step 5
End, the 3rd mixed-powder, another portion of diluent, the binding agent of 3 weight portions, the disintegrating agent of 2 weight portions, and the tune of 2 weight portions
Taste agent mix homogeneously, prepares the 4th mixed-powder, then adds after the lubricant of 1.5 weight portions mixing in the 4th mixed-powder all
Even, prepare the 5th mixed-powder, standby；
Step 7, the 5th mixed-powder prepared in step 6 is carried out tabletting, obtain the described strong tablet containing papaw
Agent.
Whiterot fungi, difference citric acid bacillus in step one described in the preparation method of the described strong tablet containing papaw
It is respectively 400CFU/mL, 600CFU/mL and 300CFU/mL with the Lactobacillus plantarum initial clump count in water.
In the preparation method of the described strong tablet containing papaw, described edible organic acid is phytic acid.
In the preparation method of the described strong tablet containing papaw, described diluent is by amylum pregelatinisatum and microcrystalline cellulose
Element mixes for 2:1 in mass ratio.
In the preparation method of the described strong tablet containing papaw, described binding agent is by hydroxypropyl cellulose, hydroxypropyl first
Cellulose and polyvidone mix for 2:2:1 in mass ratio.
In the preparation method of the described strong tablet containing papaw, described lubricant is pressed by magnesium stearate and micropowder silica gel
Mass ratio is that 3:2 mixes.
In the preparation method of the described strong tablet containing papaw, described flavoring agent is sorbitol.
<test example 1>
Animal toxicity test is reported:
After the health care tablet crushing and water-adding dilution that will obtain in embodiment of the present invention 1-3, and comparative example 1-3, as six
Group test medicinal liquid；
Taking the mice 60 of male and female half and half, every Mouse Weight is 18-22g, is equally divided into six groups, respectively with above-mentioned six groups
Test uses medicinal liquid gavage, medicinal liquid consumption to be 0.5mL/10g/ time, twice daily, serve on 7 days, observes every day and is administered reaction, knot
Fruit show 60 mices in 7 days diet normal, none dead and poisoning, it was demonstrated that prepare in embodiment 1-3, and comparative example 1-3
Medicine without bad toxic and side effects.
<test example 2>
Choose 120 female white mice, wherein aged Mus (15 monthly age) 90, body weight 48 ± 6g, few Mus in age (2 monthly age) 30
Only, body weight 29 ± 3g；It is one group by 14 aged Mus and 6 Mus in few age, is equally divided into six groups.Raise with complete granular during test
Material, ad lib and drinking-water.During off-test, (30 days) take eye socket blood and survey Content of MDA and erythrocyte sod vigor.
Treatment group 1: the strong tablet containing papaw that the embodiment of the present invention 1 obtains, feeds at twice sooner or later；
Treatment group 2: the strong tablet containing papaw that the embodiment of the present invention 2 obtains, feeds at twice sooner or later；
Treatment group 3: the strong tablet containing papaw that the embodiment of the present invention 3 obtains, feeds at twice sooner or later；
Treatment group 4: the strong tablet that comparative example 1 of the present invention obtains, feeds at twice sooner or later；
Treatment group 5: the strong tablet containing papaw that comparative example 2 of the present invention obtains, feeds at twice sooner or later；
Treatment group 6: the strong tablet that comparative example 3 of the present invention obtains, feeds at twice sooner or later.
The eye socket blood of the aged Mus often organized in treatment group with Mus in age less is surveyed Content of MDA and erythrocyte sod vigor divides
Do not average, obtain the data of table 1 below:
Table 1: treatment group 1-6 therapeutic outcome
As can be seen from Table 1, treatment group 1-3 effect is fairly obvious compared to treatment group 4-6 advantage, the little Bai for the treatment of group 3
It is minimum in six groups that the eye socket blood of Mus surveys the meansigma methods of Content of MDA, the meansigma methods of erythrocyte sod vigor be in six groups
High；Treatment group 4 is in raw material not have papaw, treatment group 5 to be former with the difference for the treatment of group 2 with the difference for the treatment of group 3
Material does not have myrtle fruit, treatment group 6 are in raw material there is no papaw and myrtle fruit, containing ten thousand longevity with the difference for the treatment of group 1
The curative effect of the tablet of fruit and myrtle fruit has obvious advantage than tablet prepared by other combination in any, illustrates what the present invention provided
The selected papaw of strong tablet, myrtle fruit Fructus Tsaoko and Semen Ginkgo containing papaw, four with the use of giving full play to pharmacology
Synergism, slow down aging is had significant curative effect.
Although embodiment of the present invention are disclosed as above, but it is not restricted in description and embodiment listed
Using, it can be applied to various applicable the field of the invention completely, for those skilled in the art, and can be easily
Realizing other amendment, therefore under the general concept limited without departing substantially from claim and equivalency range, the present invention does not limit
In specific details with shown here as the embodiment with description.
Claims (8)
1. the strong tablet containing papaw, it is characterised in that include the raw material of following parts by weight:
Papaw 10-50 part, myrtle fruit 10-30 part, Fructus Tsaoko 10-30 part and Semen Ginkgo 10-30 part.
2. the preparation method of the strong tablet containing papaw, it is characterised in that comprise the following steps:
Step one, by the Semen Ginkgo of the papaw of 10-50 weight portion, the myrtle fruit of 10-30 weight portion and 10-30 weight portion respectively
After rinsing well with clear water, dry to constant weight, pulverize, and cross 60-100 mesh sieve, prepare papaw powder, myrtle fruit powder and
Semen Ginkgo powder；After papaw powder, myrtle fruit powder and Semen Ginkgo powder mix homogeneously, it is immersed in containing whiterot fungi, difference lemon
In the water of lemon acidfast bacilli and Lactobacillus plantarum, temperature be 30-40 DEG C, after air humidity is 70-80% bottom fermentation 48-50h, will
Water is evaporated, and is milled into powder by being evaporated prepared solid afterwards, prepares the first mixed-powder, standby；
Step 2, the Fructus Tsaoko clear water of 10-30 weight portion is rinsed well after, be dried to constant weight, pulverize, and cross 60-100 mesh sieve
After, extraction temperature be 40-50 DEG C, extracting pressure is 15-25MPa and carbon dioxide flow is to carry out super facing under 80-100L/h
After boundary carbon dioxide abstraction 2-3h, prepare Fructus Tsaoko extract, standby；
Step 3, by the lysozyme of 2-10 weight portion, the lywallzyme of 10-30 weight portion, the cellulase of 1-3 weight portion, 1-3 weight
The glucosidase of the amount hemicellulase of part, the pectase of 3-5 weight portion, the ligninase of 1-2 weight portion and 1-2 weight portion adds
Enter in the water of 1000-2000 weight portion, after preparing complex enzyme liquid, the first mixed-powder prepared in step one is added compound enzyme
In liquid, after mix homogeneously, with edible organic acid regulation pH value to 4-5, enzymolysis 3-4h at 40-60 DEG C afterwards, prepare enzymolysis solution,
Standby；
Step 4, the enzymolysis solution filtration that will prepare in step 3, prepare the first filtering residue and the first filtrate, by the first filtering residue 50-
The clear water of 60 weight portions rinses 2-3 time, prepares the second filtering residue, collects simultaneously and rinse the washings obtained every time, by washing of collecting
Wash water and the first filtrate mix homogeneously, prepare the first mixed liquor, the first mixed liquor is incubated at 90-100 DEG C 20-30min, enters
After row enzyme denaturing processes, prepare the second mixed liquor, standby；
Step 5, by step 4 prepare second filtering residue add 50-60 weight portion the ethanol water that volume parts is 70-80%
In solution, after being heated to reflux 45-55min, filter, prepare the second filtrate, mix the second filtrate and step 4 prepare second
Close after liquid mix homogeneously, temperature be 45-65 DEG C, pressure be to be concentrated in vacuo under 80-90KPa, be then spray-dried, prepare second
Mixed-powder, standby；
Step 6, by two parts of the quality such as the diluent of 10-50 weight portion is divided into, by the Fructus Tsaoko extract for preparing in step 2 with
It is milled into powder after a diluent mix homogeneously, prepares the 3rd mixed-powder；By in step 5 prepare the second mixed-powder,
3rd mixed-powder, another portion of diluent, the binding agent of 2-5 weight portion, the disintegrating agent of 1-3 weight portion, and 1-2 weight portion
Flavoring agent mix homogeneously, prepares the 4th mixed-powder, more mixed after the lubricant of addition 0.5-2 weight portion in the 4th mixed-powder
Close uniformly, prepare the 5th mixed-powder, standby；
Step 7, the 5th mixed-powder prepared in step 6 is carried out tabletting, obtain the described strong tablet containing papaw.
3. the preparation method of the strong tablet containing papaw as claimed in claim 2, it is characterised in that white in described step one
Rotten bacterium, difference citric acid bacillus and the Lactobacillus plantarum initial clump count in water are respectively 300-600CFU/mL, 500-
1000CFU/mL and 200-500CFU/mL.
4. the preparation method of the strong tablet containing papaw as claimed in claim 2, it is characterised in that described edible organic acid
For any one or a few in phytic acid, citric acid, malic acid and tartaric acid.
5. the preparation method of the strong tablet containing papaw as claimed in claim 2, it is characterised in that described diluent is by can
Pressure property starch and microcrystalline Cellulose mix for 2:1 in mass ratio.
6. the preparation method of the strong tablet containing papaw as claimed in claim 2, it is characterised in that described binding agent is by hydroxyl
Propyl cellulose, hypromellose and polyvidone mix for 2:2:1 in mass ratio.
7. the preparation method of the strong tablet containing papaw as claimed in claim 2, it is characterised in that described lubricant is by firmly
Fatty acid magnesium and micropowder silica gel mix for 3:2 in mass ratio.
8. the preparation method of the strong tablet containing papaw as claimed in claim 2, it is characterised in that described flavoring agent is mountain
Any one or a few in pears alcohol, mannitol or synthetic sweetener saccharin sodium.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110179126A (en) * | 2019-05-29 | 2019-08-30 | 山东腾贵医药有限公司 | A kind of post-operative recovery preparation and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1401384A (en) * | 2002-09-12 | 2003-03-12 | 潘友中 | Pueraria root and Hovenia dulcis fruit preparation |
| CN104971513A (en) * | 2015-06-15 | 2015-10-14 | 昆明理工大学 | Method for extracting volatile oil and polyphenol from tsaoko fruit |
| CN105031037A (en) * | 2015-09-08 | 2015-11-11 | 贵州广济堂药业有限公司 | Health care product for conditioning qi stagnation constitution |
| CN105707808A (en) * | 2016-03-25 | 2016-06-29 | 邵素英 | High-stability honey paste and preparation method thereof |
-
2016
- 2016-08-29 CN CN201610756452.1A patent/CN106177737A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1401384A (en) * | 2002-09-12 | 2003-03-12 | 潘友中 | Pueraria root and Hovenia dulcis fruit preparation |
| CN104971513A (en) * | 2015-06-15 | 2015-10-14 | 昆明理工大学 | Method for extracting volatile oil and polyphenol from tsaoko fruit |
| CN105031037A (en) * | 2015-09-08 | 2015-11-11 | 贵州广济堂药业有限公司 | Health care product for conditioning qi stagnation constitution |
| CN105707808A (en) * | 2016-03-25 | 2016-06-29 | 邵素英 | High-stability honey paste and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 窦国祥: "《家庭饮食营养宜忌全书》", 30 September 2010, 安徽科学技术出版社 * |
| 苗明三: "《中药彩色图谱：速认、速记、速用》", 30 September 2015, 山西科学技术出版社 * |
| 赖来展: "《黑色食品与健康长寿》", 31 October 2014, 金盾出版社 * |
| 高学敏: "《中国药典中药材及饮品彩色图鉴》", 31 March 2015, 山西科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110179126A (en) * | 2019-05-29 | 2019-08-30 | 山东腾贵医药有限公司 | A kind of post-operative recovery preparation and preparation method thereof |
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