CN110179126A - A kind of post-operative recovery preparation and preparation method thereof - Google Patents
A kind of post-operative recovery preparation and preparation method thereof Download PDFInfo
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- CN110179126A CN110179126A CN201910459939.7A CN201910459939A CN110179126A CN 110179126 A CN110179126 A CN 110179126A CN 201910459939 A CN201910459939 A CN 201910459939A CN 110179126 A CN110179126 A CN 110179126A
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- operative recovery
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- 238000002360 preparation method Methods 0.000 title claims abstract description 50
- 238000011084 recovery Methods 0.000 title claims abstract description 40
- 230000002980 postoperative effect Effects 0.000 title claims abstract description 39
- 239000000843 powder Substances 0.000 claims abstract description 46
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 40
- 102000008186 Collagen Human genes 0.000 claims abstract description 37
- 108010035532 Collagen Proteins 0.000 claims abstract description 37
- MVORZMQFXBLMHM-QWRGUYRKSA-N Gly-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CN=CN1 MVORZMQFXBLMHM-QWRGUYRKSA-N 0.000 claims abstract description 37
- 229920001436 collagen Polymers 0.000 claims abstract description 37
- 108010038983 glycyl-histidyl-lysine Proteins 0.000 claims abstract description 37
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 36
- 235000021388 linseed oil Nutrition 0.000 claims abstract description 24
- 239000000944 linseed oil Substances 0.000 claims abstract description 24
- 239000003094 microcapsule Substances 0.000 claims abstract description 24
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 22
- DWNBOPVKNPVNQG-LURJTMIESA-N (2s)-4-hydroxy-2-(propylamino)butanoic acid Chemical compound CCCN[C@H](C(O)=O)CCO DWNBOPVKNPVNQG-LURJTMIESA-N 0.000 claims abstract description 21
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 20
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 20
- 229930003316 Vitamin D Natural products 0.000 claims abstract description 20
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 20
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000011575 calcium Substances 0.000 claims abstract description 20
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 20
- 239000011726 vitamin B6 Substances 0.000 claims abstract description 20
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 20
- 239000011718 vitamin C Substances 0.000 claims abstract description 20
- 235000019166 vitamin D Nutrition 0.000 claims abstract description 20
- 239000011710 vitamin D Substances 0.000 claims abstract description 20
- 150000003710 vitamin D derivatives Chemical class 0.000 claims abstract description 20
- 229940046008 vitamin d Drugs 0.000 claims abstract description 20
- 239000011701 zinc Substances 0.000 claims abstract description 20
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 20
- 239000011715 vitamin B12 Substances 0.000 claims abstract description 19
- 229960003080 taurine Drugs 0.000 claims abstract description 18
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims abstract description 17
- 239000011716 vitamin B2 Substances 0.000 claims abstract description 17
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000003292 glue Substances 0.000 claims abstract description 15
- 229960003512 nicotinic acid Drugs 0.000 claims abstract description 15
- 235000001968 nicotinic acid Nutrition 0.000 claims abstract description 15
- 239000011664 nicotinic acid Substances 0.000 claims abstract description 15
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims abstract description 9
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims abstract description 9
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims abstract description 6
- 229930003270 Vitamin B Natural products 0.000 claims abstract description 5
- 235000019156 vitamin B Nutrition 0.000 claims abstract description 5
- 239000011720 vitamin B Substances 0.000 claims abstract description 5
- 239000012876 carrier material Substances 0.000 claims description 14
- 238000009472 formulation Methods 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 11
- 239000011691 vitamin B1 Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 229960004203 carnitine Drugs 0.000 claims description 5
- 238000004108 freeze drying Methods 0.000 claims description 4
- 210000004185 liver Anatomy 0.000 claims description 4
- 235000012054 meals Nutrition 0.000 claims description 4
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 4
- 229940104273 niacin 0.15 mg Drugs 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 238000009736 wetting Methods 0.000 claims description 3
- 235000019733 Fish meal Nutrition 0.000 claims description 2
- 241000287828 Gallus gallus Species 0.000 claims description 2
- 240000008042 Zea mays Species 0.000 claims description 2
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 claims description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 2
- 125000002252 acyl group Chemical group 0.000 claims description 2
- 235000015278 beef Nutrition 0.000 claims description 2
- 238000005119 centrifugation Methods 0.000 claims description 2
- 239000004467 fishmeal Substances 0.000 claims description 2
- 238000000265 homogenisation Methods 0.000 claims description 2
- 235000009973 maize Nutrition 0.000 claims description 2
- 235000015277 pork Nutrition 0.000 claims description 2
- 244000046052 Phaseolus vulgaris Species 0.000 claims 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 239000005864 Sulphur Substances 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 239000013049 sediment Substances 0.000 claims 1
- 230000006870 function Effects 0.000 abstract description 7
- 235000016709 nutrition Nutrition 0.000 abstract description 3
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 230000032823 cell division Effects 0.000 abstract description 2
- 238000013329 compounding Methods 0.000 abstract description 2
- 230000035764 nutrition Effects 0.000 abstract description 2
- 230000007661 gastrointestinal function Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 235000010469 Glycine max Nutrition 0.000 description 14
- 230000000694 effects Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 6
- 241000251468 Actinopterygii Species 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 235000014347 soups Nutrition 0.000 description 3
- 244000068988 Glycine max Species 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- 235000019750 Crude protein Nutrition 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930003451 Vitamin B1 Natural products 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- LXNHXLLTXMVWPM-UHFFFAOYSA-N Vitamin B6 Natural products CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 235000019621 digestibility Nutrition 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 235000021271 drinking Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000037111 immune power Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 229940096435 niacin 25 mg Drugs 0.000 description 1
- 229940079464 niacin 50 mg Drugs 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of post-operative recovery preparations and preparation method thereof, include linseed oil microcapsule powder, soy peptide powder, bone collagen Gly-His-Lys, Isin glue collagen Gly-His-Lys, N- acetyl mind propylhomoserin, vitamin C, niacin, vitamin D, vitamin B in post-operative recovery preparation1, vitamin B2, vitamin B6, vitamin B12, zinc, calcium, L-carnitine, taurine, surplus be carrier; carrying out compounding using a variety of nutrition active principles makes synergistic function between it; promote the reparation of the gastrointestinal function of postoperative stimulation; promote cell division; and then promoting the absorption of nutriment and the recovery of wound, and preparation process condition of the invention is mildly controllable, obtained tablet or electuary are easy to carry easy to use; it is not limited by place and time, there is extensive application value.
Description
Technical field
The present invention relates to functional food technical field, in particular to a kind of post-operative recovery preparation and preparation method thereof.
Background technique
With the further development of medical technology, operation be treated in modern society disease it is a kind of quickly and efficiently
Means, can be replaced and be cut off for lesion internal organ, but since human body has a tenability limit to environmental stimuli, one
Reach the limit after denier operation, then function of human body can be damaged, cause disorder, unhealthful recovery.
In view of the above-mentioned problems, the prior art mainly adopts traditional theory, postoperative big benefit is supported through diet and slowly as postoperative
The important means of recovery, all food of but not are suitable for post-operative recovery, as passed through in traditional theory frequently with pig bone made soup
Deng progress tonic, although containing nutriment in pig bone made soup, its content is smaller, if to reach post-operative recovery demand water
It is flat, then a large amount of long-term drinkings are needed, not only restore slow, but also the high fat content in pig bone made soup can also cause hyperlipidemia and obesity
Risk, to be unfavorable for post-operative recovery.It, should in the prior art there are also the means for carrying out post-operative recovery using single medicine preparation
Technological means single effect, can not across-the-board regulation body make its fast quick-recovery normal condition, function is limited；It is important that existing skill
The means operation of dietotherapy and medication in art is complex, can not accomplish the feature eaten at any time, more limit its application.
Therefore how to provide a kind of with comprehensive adjustment effect and post-operative recovery preparation convenient to use, it is this field skill
Art personnel's urgent problem to be solved.
Summary of the invention
In view of this, the present invention provides a kind of post-operative recovery preparation and preparation method thereof rich in full nutrition substance,
Using the nutriment cooperation adjustment function of human body of a variety of needed by human body, can quickly get well and easy to use.
In order to reach said effect, the present invention adopts the following technical scheme:
First the present invention provides a kind of post-operative recovery preparation, include in every 0.5g preparation linseed oil microcapsule powder 15~
300mg, 15~300mg of soy peptide powder, 25~300mg of bone collagen Gly-His-Lys, 20~300mg of Isin glue collagen Gly-His-Lys, N- second
Acyl mind propylhomoserin 0.05-50mg, 0.05~250mg of vitamin C, 0.0075~150mg of niacin, vitamin D 0.000005~
0.0004mg, vitamin B10.0005~0.4mg, vitamin B20.0005~0.4mg, vitamin B60.0005~0.4mg, dimension
Raw element B120.000005~0.0012mg, 0.004~3.2mg of zinc, 0.225~180mg of calcium, 0.75~300mg of L-carnitine, ox
0.03~250mg of sulfonic acid, surplus are carrier.
It include linseed oil microcapsule powder 104.41146mg, soybean in every 0.5g preparation as the preferred embodiment of above-mentioned technology
Gly-His-Lys 105mg, bone collagen Gly-His-Lys 125mg, Isin glue collagen Gly-His-Lys 110mg, N- acetyl mind propylhomoserin 5mg, vitamin C
1mg, niacin 0.15mg, vitamin D 0.00001mg, vitamin B10.01mg, vitamin B20.01mg, vitamin
B60.001mg, vitamin B120.00003mg, zinc 0.08mg, calcium 4.5mg, L-carnitine 15mg, taurine 0.6mg, surplus are
Carrier.
Preferably, the carrier is one of maize cob meal, starch, fish meal, powdered beef, pork liver powder, chicken liver meal or more
Kind.
It is another object of the present invention to provide a kind of preparation methods of post-operative recovery formulation tablet, including following step
It is rapid:
(4.1) example weighs linseed oil microcapsule powder, soy peptide powder, bone collagen Gly-His-Lys, Isin glue collagen in mass ratio
Gly-His-Lys, N- acetyl mind propylhomoserin, vitamin C, niacin, vitamin D, vitamin B1, vitamin B2, vitamin B6, vitamin B12, zinc,
Calcium, L-carnitine, taurine and carrier material, it is spare；
(4.2) soy peptide powder that claims the step (4.1), bone collagen Gly-His-Lys, Isin glue collagen Gly-His-Lys, left-handed
Carnitine is dispersed in pure water solution and stirs evenly, and obtains the first mixed liquor；
(4.3) N- acetyl mind propylhomoserin, the vitamin C, vitamin D, vitamin B for claiming the step (4.1)1, dimension life
Plain B2, vitamin B6, vitamin B12, zinc, calcium, taurine be dispersed in pure water solution and stir evenly, obtain the second mixed liquor；
(4.4) the second mixed liquor made from the first mixed liquor made from the step (4.2) and the step (4.3) is mixed
Merging stirs evenly, and niacin is added later and linseed oil microcapsule powder stirs evenly, is placed in homogeneous in homogenizer, obtains third mixing
Liquid；
(4.5) carrier material is added in third mixed liquor made from Xiang Suoshu step (4.4), is concentrated into carrier material later
In wet discrete particles shape, the carrier material of wetting is then placed in tabletting in mold, finally dries to moisture content 3~5% and wraps
It fills up to post-operative recovery formulation tablet.
Preferably, the mixing speed in the step (4.2) is 150~300r/min, 5~15min of mixing time.
Preferably, the mixing speed in the step (4.3) is 200~300r/min, 5~15min of mixing time.
Preferably, step (4.4) 10~20MPa of homogenization pressure.
Preferably, the concentration in the step (4.5) is concentrated using vacuum and low temperature, dry using freeze-drying.
Preferably, vacuum and low temperature concentration setting 10~60Pa of vacuum degree in the step (4.5), 20 DEG C~50 DEG C of temperature,
1000~1500r/min centrifugation；- 50 DEG C~-55 DEG C of cryogenic temperature of freeze-drying setting, 10~60Pa of vacuum degree.
The present invention also provides a kind of preparation method of post-operative recovery preparation electuary, using the preparation method of above-mentioned tablet,
It is different, linseed oil microcapsule powder is added without in step (4.4), in step (4.5) after mixed carrier material not into
Row concentration, is directly spray-dried, and is collected dried powder and is wrapped after mixing by specification with linseed oil microcapsule powder
Dress is to get post-operative recovery preparation electuary.
In conclusion compared to the prior art, the present invention has the following technical effect that the present invention uses a variety of nutriments
Compounding, wherein in linseed oil microcapsule powder the sum of crude protein, fat, total sugar content be up to 84.07%, and rich in amino acid,
Microelement and fatty acid, nutritive value are high；Amino acid is rich in soybean peptide, ox bone peptide and Isin glue collagen peptide, wherein wrapping
Containing the essential amino acid that a variety of human bodies cannot synthesize, and peptide is the protein of small molecule, is very easy to be absorbed by the body, and is suitble to art
Digestive function weakness protein digestibility absorbs bad crowd and eats afterwards, and to supplement protein, and peptide also has raising immune
Power, the effect of enhancing physical strength, relieving fatigue；Vitamins can boost metabolism, and maintain the health of skin and muscle, promote
The function of immune system and nervous system promotes cell growth and division, promotes wound healing；N- acetyl mind propylhomoserin can prevent disease
Bacterium intrusion；Niacin has the effect of adjusting function of intestinal canal, and then promotes the absorption of nutriment；Above-mentioned a variety of nutriment collaborations
Synergy promotes the process of post-operative recovery from many aspects；And above-mentioned nutriment and carrier are prepared into tablet or punching in the present invention
Agent, it is convenient to use, not by place and time restriction, and then post-operative recovery process can be promoted；It is important that the present invention provides
Preparation method it is simple and easy to operate, reaction condition is mild, application value with higher.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical solution in the embodiment of the present invention is clearly and completely retouched
It states, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based on the present invention
In embodiment, every other implementation obtained by those of ordinary skill in the art without making creative efforts
Example, shall fall within the protection scope of the present invention.
Embodiment 1
A kind of preparation method of post-operative recovery formulation tablet, comprising the following steps:
(4.1) example weighs linseed oil microcapsule powder, soy peptide powder, bone collagen Gly-His-Lys, Isin glue collagen in mass ratio
Gly-His-Lys, N- acetyl mind propylhomoserin, vitamin C, niacin, vitamin D, vitamin B1, vitamin B2, vitamin B6, vitamin B12, zinc,
Calcium, L-carnitine, taurine and carrier material, it is spare；
(4.2) N- acetyl mind propylhomoserin, the vitamin C, vitamin D, vitamin B for claiming the step (4.1)1, dimension life
Plain B2, vitamin B6, vitamin B12, zinc, calcium, taurine be dispersed to 150~300r/min in pure water solution and stir 5~15min,
Obtain the first mixed liquor；
(4.3) N- acetyl mind propylhomoserin, the vitamin C, vitamin D, vitamin B for claiming the step (4.1)1, dimension life
Plain B2, vitamin B6, vitamin B12, zinc, calcium, taurine be dispersed to 200~300r/min in pure water solution and stir 5~15min,
Obtain the second mixed liquor；
(4.4) the first mixed liquor made from step (4.2) and the second mixed liquor made from step (4.3) are mixed and stirred for
Uniformly, niacin is added later and linseed oil microcapsule powder stirs evenly, be placed in 10~20MPa homogeneous 5-15min in homogenizer, obtain
Third mixed liquor；
(4.5) carrier material is added into third mixed liquor made from step (4.4), later be arranged vacuum degree 10~
60Pa, 20 DEG C~50 DEG C of temperature, it is in wet discrete particles shape that 1000~1500r/min vacuum and low temperature, which is concentrated into carrier material, so
The carrier material of wetting is placed in tabletting in mold afterwards, is finally arranged -50 DEG C~-55 DEG C of cryogenic temperature, 10~60Pa of vacuum degree,
Freeze-drying to moisture content 3~5% is packed up to post-operative recovery formulation tablet.
Embodiment 2
A kind of preparation method of post-operative recovery preparation electuary, using the technology of preparing of embodiment 1, different from embodiment 1
Aspect is that linseed oil microcapsule powder is added without in step (4.4), without being concentrated after mixed carrier material in step (4.5),
Directly be spray-dried, collect dried powder and with linseed oil microcapsule powder after mixing by specification packed to get
Post-operative recovery preparation electuary.
Specific material rate will be selected as embodiment 3-6 below, using the preparation of above-described embodiment 1 or embodiment 2
Method prepares tablet or electuary, and specific ratio is as follows:
Embodiment 3
In every 0.5g preparation include linseed oil microcapsule powder 15mg, soy peptide powder 300mg, bone collagen Gly-His-Lys 25mg,
Isin glue collagen Gly-His-Lys 20mg, N- acetyl mind propylhomoserin 0.05mg, vitamin C 0.05mg, niacin 0.0075mg, vitamin D
0.0004mg, vitamin B10.0005mg, vitamin B20.4mg, vitamin B60.0005mg, vitamin B120.000005mg, zinc
3.2mg, calcium 0.225mg, L-carnitine 0.75mg, taurine 0.03mg, surplus are carrier.
Embodiment 4
In every 0.5g preparation include linseed oil microcapsule powder 15mg, soy peptide powder 300mg, bone collagen Gly-His-Lys 25mg,
Isin glue collagen Gly-His-Lys 20mg, N- acetyl mind propylhomoserin 10mg, vitamin C 15mg, niacin 25mg, vitamin D 0.0004mg, dimension
Raw element B10.4mg, vitamin B20.4mg, vitamin B60.4mg, vitamin B120.0012mg, zinc 3.2mg, calcium 0.225mg, a left side
Revolving carnitine 1.5mg, taurine 3mg, surplus is carrier.
Embodiment 5
In every 0.5g preparation include linseed oil microcapsule powder 15mg, soy peptide powder 15mg, bone collagen Gly-His-Lys 300mg,
Isin glue collagen Gly-His-Lys 20mg, N- acetyl mind propylhomoserin 50mg, vitamin C 0.05mg, niacin 0.0075mg, vitamin D
0.0004mg, vitamin B10.0005mg, vitamin B20.4mg, vitamin B60.4mg, vitamin B120.000005mg, zinc
3.2mg, calcium 30mg, L-carnitine 20mg, taurine 0.03mg, surplus are carrier.
Embodiment 6
It include linseed oil microcapsule powder 104.41146mg, soy peptide powder 105mg, bone collagen peptide in every 0.5g preparation
Powder 125mg, Isin glue collagen Gly-His-Lys 110mg, N- acetyl mind propylhomoserin 5mg, vitamin C 1mg, niacin 0.15mg, vitamin D
0.00001mg, vitamin B1 0.01mg, vitamin B2 0.01mg, vitamin B6 0.001mg, vitamin B12
0.00003mg, zinc 0.08mg, calcium 4.5mg, L-carnitine 15mg, taurine 0.6mg, surplus are carrier.
Embodiment 7
It include linseed oil microcapsule powder 15mg, soy peptide powder 15mg, bone collagen Gly-His-Lys 25mg, fish in every 0.5g preparation
Collagen Gly-His-Lys 300mg, N- acetyl mind propylhomoserin 50mg, vitamin C 0.05mg, niacin 0.0075mg, vitamin D
0.0004mg, vitamin B10.0005mg, vitamin B20.4mg, vitamin B60.0005mg, vitamin B120.0012mg, zinc
0.004mg, calcium 0.225mg, L-carnitine 0.75mg, taurine 0.03mg, surplus are carrier.
Embodiment 8
It include linseed oil microcapsule powder 15mg, soy peptide powder 15mg, bone collagen Gly-His-Lys 25mg, fish in every 0.5g preparation
Collagen Gly-His-Lys 20mg, N- acetyl mind propylhomoserin 30mg, vitamin C 20mg, niacin 30mg, vitamin D 0.0004mg, dimension life
Plain B10.0005mg, vitamin B20.4mg, vitamin B60.0005mg, vitamin B120.0012mg, zinc 3.2mg, calcium 10mg, a left side
Revolving carnitine 20mg, taurine 0.03mg, surplus is carrier.
Embodiment 9
It include linseed oil microcapsule powder 15mg, soy peptide powder 15mg, bone collagen Gly-His-Lys 25mg, fish in every 0.5g preparation
Collagen Gly-His-Lys 20mg, N- acetyl mind propylhomoserin 15mg, vitamin C 250mg, niacin 50mg, vitamin D 0.0004mg, dimension
Raw element B10.4mg, vitamin B20.4mg, vitamin B60.4mg, vitamin B120.0012mg, zinc 3.2mg, calcium 50mg, left-handed meat
Alkali 30mg, taurine 10mg, surplus are carrier.
Embodiment 10
It include linseed oil microcapsule powder 15mg, soy peptide powder 15mg, bone collagen Gly-His-Lys 25mg, fish in every 0.5g preparation
Collagen Gly-His-Lys 20mg, N- acetyl mind propylhomoserin 35mg, vitamin C 20mg, niacin 150mg, vitamin D 0.0004mg, dimension
Raw element B10.4mg, vitamin B20.4mg, vitamin B60.4mg, vitamin B12It is 0.0012mg, zinc 3.2mg, calcium 180mg, left-handed
Carnitine 15mg, taurine 0.03mg, surplus are carrier.
Test example
It is done work using post-operative recovery preparation made from above-described embodiment 3-10 and certain commercially available post-operative recovery nutritional agents of comparative example
It can compare, process and result are as follows:
Identical and healthy mouse 90 of specification are chosen, simulation operation is carried out to each mouse and establishes postoperative mouse model,
It is randomly divided into 9 groups later, every group 10, is denoted as A, B, C, D, E, F, G, H, I group, respectively corresponds embodiment 3-10 and comparative example
Group, every group feeds preparation 5g daily, continuously feeds 30 days, records recovery effects.
It is found through overtesting, the mouse for taking A, B, C, D, E, F, G, H group of the preparation of 3-10 of the embodiment of the present invention exists more
Restore normal physical function in 15-20 days, wherein the mouse of D group restores most fast, and G group mouse is not also completely extensive in 30 days
It is multiple, it can be seen that, technical solution of the present invention compared to the prior art for, have the effect of superior promotion post-operative recovery.
Each embodiment in this specification is described in a progressive manner, the highlights of each of the examples are with other
The difference of embodiment, the same or similar parts in each embodiment may refer to each other.For device disclosed in embodiment
For, since it is corresponded to the methods disclosed in the examples, so being described relatively simple, related place is said referring to method part
It is bright.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention.
Various modifications to these embodiments will be readily apparent to those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention
It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one
The widest scope of cause.
Claims (9)
1. a kind of post-operative recovery preparation, which is characterized in that include 15~300mg of linseed oil microcapsule powder in every 0.5g preparation, big
15~300mg of beans Gly-His-Lys, 25~300mg of bone collagen Gly-His-Lys, 20~300mg of Isin glue collagen Gly-His-Lys, N- acetyl mind propylhomoserin
0.05-50mg, 0.05~250mg of vitamin C, 0.0075~150mg of niacin, 0.000005~0.0004mg of vitamin D, dimension
Raw element B10.0005~0.4mg, vitamin B20.0005~0.4mg, vitamin B60.0005~0.4mg, vitamin
B120.000005~0.0012mg, 0.004~3.2mg of zinc, 0.225~180mg of calcium, 0.75~300mg of L-carnitine, taurine
0.03~250mg, surplus are carrier.
2. a kind of post-operative recovery preparation according to claim 1, which is characterized in that include linseed oil in every 0.5g preparation
Microcapsule powder 104.41146mg, soy peptide powder 105mg, bone collagen Gly-His-Lys 125mg, Isin glue collagen Gly-His-Lys 110mg, N- second
Acyl mind propylhomoserin 5mg, vitamin C 1mg, niacin 0.15mg, vitamin D 0.00001mg, vitamin B10.01mg, vitamin
B20.01mg, vitamin B60.001mg, vitamin B120.00003mg, zinc 0.08mg, calcium 4.5mg, L-carnitine 15mg, ox sulphur
Sour 0.6mg, surplus are carrier.
3. according to claim 1 or a kind of post-operative recovery preparation, which is characterized in that the carrier is maize cob meal, forms sediment
One of powder, fish meal, powdered beef, pork liver powder, chicken liver meal are a variety of.
4. a kind of preparation method of post-operative recovery formulation tablet described in claim 1-3, which is characterized in that including following step
It is rapid:
(4.1) in mass ratio example weigh linseed oil microcapsule powder, soy peptide powder, bone collagen Gly-His-Lys, Isin glue collagen Gly-His-Lys,
N- acetyl mind propylhomoserin, vitamin C, niacin, vitamin D, vitamin B1, vitamin B2, vitamin B6, vitamin B12, zinc, calcium, a left side
Carnitine, taurine and carrier material are revolved, it is spare；
(4.2) soy peptide powder that claims the step (4.1), bone collagen Gly-His-Lys, Isin glue collagen Gly-His-Lys, L-carnitine
It is dispersed in pure water solution and stirs evenly, obtain the first mixed liquor；
(4.3) N- acetyl mind propylhomoserin, the vitamin C, vitamin D, vitamin B for claiming the step (4.1)1, vitamin B2、
Vitamin B6, vitamin B12, zinc, calcium, taurine be dispersed in pure water solution and stir evenly, obtain the second mixed liquor；
(4.4) the first mixed liquor made from the step (4.2) is mixed simultaneously with the second mixed liquor made from the step (4.3)
It stirs evenly, niacin is added later and linseed oil microcapsule powder stirs evenly, is placed in homogeneous in homogenizer, obtains third mixed liquor；
(4.5) carrier material is added in third mixed liquor made from Xiang Suoshu step (4.4), is concentrated into carrier material later in wet
Moisten discrete particles shape, the carrier material of wetting is then placed in tabletting in mold, finally dry pack to moisture content 3~5% is
Obtain post-operative recovery formulation tablet.
5. a kind of preparation method of post-operative recovery formulation tablet according to claim 4, which is characterized in that the step
(4.2) mixing speed in is 150~300r/min, 5~15min of mixing time.
6. a kind of preparation method of post-operative recovery formulation tablet according to claim 4, which is characterized in that the step
(4.3) mixing speed in is 200~300r/min, 5~15min of mixing time.
7. a kind of preparation method of post-operative recovery formulation tablet according to claim 4, which is characterized in that the step
(4.4) 10~20MPa of homogenization pressure.
8. a kind of preparation method of post-operative recovery formulation tablet according to claim 4, which is characterized in that the step
(4.5) concentration in is concentrated using vacuum and low temperature, dry using freeze-drying.
9. a kind of preparation method of post-operative recovery formulation tablet according to claim 8, which is characterized in that the step
(4.5) vacuum and low temperature concentration setting 10~60Pa of vacuum degree in, 20 DEG C~50 DEG C of temperature, 1000~1500r/min centrifugation；Freezing
Dry -50 DEG C~-55 DEG C of cryogenic temperature of setting, 10~60Pa of vacuum degree.
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