CN108158885A - Repair composition of striae of pregnancy and its preparation method and application - Google Patents
Repair composition of striae of pregnancy and its preparation method and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
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- A61Q19/08—Anti-ageing preparations
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Abstract
The present invention relates to a kind of compositions for repairing striae of pregnancy and its preparation method and application.A kind of composition for repairing striae of pregnancy, in terms of mass fraction, raw material includes：5 parts~15 parts of alligator oil, 1 part~3 parts of tocopherol, 40 parts~120 parts of hamamelis and 20 parts~50 parts of purslane.The composition of above-mentioned reparation striae of pregnancy can repair epidermis, skin corium and the subcutaneous fat, antibacterial anti-inflammatory, the effect to boost metabolism of skin, good to the repairing effect of striae of pregnancy.
Description
Technical field
The present invention relates to a kind of compositions for repairing striae of pregnancy and its preparation method and application.
Background technology
Striae of pregnancy, also referred to as dilatancy striped are a kind of linear skin damages of corium.Generally in pregnancy about
The pregnant woman of 60%-90% can generate striae of pregnancy.Striae of pregnancy early stage shows as kermesinus or aubergine, then depigmentation,
Relaxation, atrophy show the wrinkle pattern appearance of a kind of white or silver color after stablizing.It is distributed mainly on abdomen, is also found in
Chest, the back of the body, buttocks and four limbs proximal end.Gestation skin can gradually be drawn with the subcutaneous tissue such as expansion of fat and muscle
It stretches, leads to skin corium connective tissue damage, collagenous fibres and elastomer are destroyed, and extensibility and elasticity weaken, so as to generate
The skin lesion of striated.
It is many in the method for beauty professional domain treatment striae of pregnancy both at home and abroad at present, mainly including external medication, instrument
The effect of device treatment, acupuncture therapy, combination therapy, but this all still some experimental treatment, various methods, which still has, strives
View.Wherein, the experiment of external medication such as glycolic, retinoid drug (tazarotene, A Padalin etc.) proves that its is right
Striae of pregnancy has a certain curative effect, but may cause skin irritation symptom after this kind of drug of application, such as burning sensation, erythema and furfur,
It may become apparent from skin lesion, and not all patient can use retinoid drug.In addition, currently for striae of pregnancy
Product focuses on the reparation of skin corium knot hoof tissue, promotes the reparation and synthesis of collagen and elastin laminin, improves skin
Elasticity, weaken the width of striae of pregnancy, length and color, but repairing effect is still not ideal enough.
Invention content
Based on this, it is necessary to currently for repair striae of pregnancy product repairing effect it is undesirable the problem of, one kind is provided and is repaiied
Composition of combined pregnancy line and its preparation method and application.
A kind of composition for repairing striae of pregnancy, in terms of mass fraction, raw material includes：
5 parts~15 parts of alligator oil, 1 part~3 parts of tocopherol, 40 parts~120 parts of hamamelis and 20 parts~50
The purslane of part.
The composition of above-mentioned reparation striae of pregnancy, using alligator oil, tocopherol, hamamelis and purslane as raw material, each group
Fibroblastic a large amount of proliferation of skin can be promoted by point cooperating, so as to promote to secrete clostridiopetidase A, activation periphery cell,
The Reconstruction of The Function of cell tissue is completed, gradually fills up, substitute the impaired elastic fibers cell tissue of fracture.Above-mentioned reparation striae of pregnancy
Composition can repair the epidermis, skin corium and subcutaneous fat of skin.The composition of above-mentioned reparation striae of pregnancy also has antibacterial
Effect that is anti-inflammatory, boosting metabolism, is experimentally verified that, good for the repairing effect of striae of pregnancy.
Raw material further includes in one of the embodiments,：1 part~2.5 parts of cetearyl glucoside, 3 parts~8 parts
Butanediol, 3 parts~8 parts of stearine, 1.5 parts~4 parts of Butyrospermum parkii fruit fat, 0.1 part~0.5 part of allantoin,
0.1 part~0.45 part of carbomer, 0.5 part~1.5 parts of double hydroxy methylimidazole ureines, 1 part~3 parts of vaseline, 2 parts~9
The glycerine and 10 parts~18 parts of Jojoba seed of part.
A kind of composition for repairing striae of pregnancy, in terms of mass fraction, includes 5 parts~15 parts of alligator oil, 1 part~3 parts
Tocopherol, 2 parts~6 parts of hamamelis extract, 1 part~2.5 parts of purslane extract.
The composition of above-mentioned reparation striae of pregnancy is extracted including alligator oil, tocopherol, hamamelis extract and purslane
Object has the function of antibacterial anti-inflammatory, boosts metabolism, and the repairing effect of striae of pregnancy is good.
The composition for repairing striae of pregnancy in one of the embodiments, further includes 1 part~2.5 parts of cetearyl glucose
Glycosides, 3 parts~8 parts of butanediol, 3 parts~8 parts of stearine, 1.5 parts~4 parts of Butyrospermum parkii fruit fat, 0.1 part~
0.5 part of allantoin, 0.1 part~0.45 part of carbomer, 0.5 part~1.5 parts of double hydroxy methylimidazole ureines, 1 part~3 parts
Vaseline, 2 parts~9 parts glycerine and 1 part~1.8 parts of jojoba seed oil.
The preparation method of the composition of above-mentioned reparation striae of pregnancy, includes the following steps：
By the allantoin, the jojoba seed oil, the butanediol, the carbomer, the glycerine, North America gold
Thread prunus mume extract and the purslane extract are stirred, and obtain the first mixed liquor；
By the alligator oil, the cetearyl glucoside, the stearine, the vaseline, the butter
Fruit tree fruit fat and the tocopherol are stirred, and obtain the second mixed liquor；
After first mixed liquor and second mixed liquor are stirred, double hydroxy methylimidazole ureines are added in
It is stirred, obtains repairing the composition of striae of pregnancy.
The preparation method of the composition of above-mentioned reparation striae of pregnancy, raw material are easy to get, and preparation process is simple, to realize industrialization.
Application of the composition of above-mentioned reparation striae of pregnancy in skin care item or in preparing the drug for repairing striae of pregnancy.
A kind of skin care item include the composition of above-mentioned reparation striae of pregnancy.
The skin care item are aqua, emulsion, paste or tablet in one of the embodiments,.
The acceptable auxiliary material of skin care item, the acceptable auxiliary material choosing of skin care item are further included in one of the embodiments,
From at least one of moisturizer, thickener and emulsifier；The moisturizer be selected from 1,3- propylene glycol, saualane and 1,2- oneself two
At least one of alcohol；The thickener is selected from least one of xanthans, microcrystalline cellulose and sodium cellulose glycolate；Institute
It states emulsifier and is selected from least one of glycerin monostearate, cetostearyl alcohol, the smooth palmitate of sorb and lanolin.
Said medicine has the function of moisturizing, antibacterial anti-inflammatory, boosts metabolism, and the repairing effect of striae of pregnancy is good.
A kind of drug includes the composition of above-mentioned reparation striae of pregnancy.
Said medicine has the function of antibacterial anti-inflammatory, boosts metabolism, and the repairing effect of striae of pregnancy is good.
Specific embodiment
For the ease of understanding the present invention, below mainly in combination with repair composition and its preparation method and application of striae of pregnancy into
Row a more complete description.But the present invention can realize in many different forms, however it is not limited to implementation described herein
Example.On the contrary, the purpose for providing these embodiments is to make the disclosure of invention more thorough and comprehensive.
Unless otherwise defined, all of technologies and scientific terms used here by the article is with belonging to technical field of the invention
The normally understood meaning of technical staff is identical.Term used in the description of the invention herein is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.
The composition of the reparation striae of pregnancy of one embodiment, in terms of mass fraction, raw material includes：
5 parts~15 parts of alligator oil, 1 part~3 parts of tocopherol, 40 parts~120 parts of hamamelis and 20 parts~50
The purslane of part.
Contain abundant amino acid, polyunsaturated fatty acid (such as DHA, DPA, EPA) and trace element etc. in alligator oil,
Human body cell can be stimulated to secret out of cell recombinant factor, the damaged cell of aging is decomposed, boost metabolism, enhancing cell is lived
Power, meanwhile, alligator oil has good permeability, easily receives and absorbs for human body.As the composition for repairing striae of pregnancy
Component, alligator oil can speed up the infiltration and absorption of other components, while promote fibroblastic a large amount of proliferation, so as to promote
Clostridiopetidase A is secreted, activation periphery cell, the Reconstruction of The Function for completing cell tissue are gradually filled up, substitute the impaired elastic fibers of fracture
Cell tissue achievees the effect that repair epidermis, skin corium and subcutaneous fat cells.The alligator oil of present embodiment comes from Siam
Crocodile, in yellow oily liquid, not soluble in water, inflammable, alligator oil is purchased from Guangdong Hongyi Crocodile Industry Co., Ltd..
Alligator oil is 8 parts~14 parts, further preferably 10 parts~13 parts in one of the embodiments,.Tocopherol,
Claim vitamin E, be common in safflower oil, Semen Benincasae oil and wheat germ oil.Tocopherol is a kind of fat-soluble antioxidant, Ke Yiyou
Effect prevents the formation of activating oxide during fat oxidation.As the component for the composition for repairing striae of pregnancy, vitamin E can be protected
Skin enables skin flexible.The protein active mechanism of vitamin E energy stabilizing cell membrane promotes the normal development and holding of muscle
The elasticity of skin enables skin and body maintain vigour；Vitamin E, which enters Skin Cell, more can directly help skin confrontation freely
The infringement of base, ultraviolet light and pollutant reduces the deposition of scar and pigment；Accelerate the healing of wound.It slows down aging, effectively reduces
The generation of wrinkle, the appearance to retain youth.
Tocopherol is 1.5 parts~3 parts, further preferably 2 parts~3 parts in one of the embodiments,.
Hamamelis also known as Virginia witch hazel, Fu Nijiya witch hazels, are Hamamelidaceaes, one kind of Hamamelis
Machaka, branch, leaf and the bark of hamamelis can be used as medicine.Extract is main in hamamelis bark and leaf
Ingredient includes tannic acid, gallic acid, catechin, procyanidine, Protoapigenone (Kaempferol, Quercetin), essential oil (Sheep's-parsley
Phenol, eugenol, hexenol), choline and saponin.Hamamelis extract is a kind of very strong antioxidant and astringent.Make
Component for the composition for repairing striae of pregnancy, the hamamelis of present embodiment refer to the bark of hamamelis and leaf portion,
It adopts and its active ingredient is extracted with water, obtained hamamelis extract.
Hamamelis is 50 parts~120 parts, further preferably 60 parts~120 parts in one of the embodiments,.
Purslane is annual herb, purslane contain two abundant oxyethylamines, malic acid, glucose, calcium, phosphorus, iron with
And the nutriments such as vitamin E, carrotene, vitamin B, vitamin C.Purslane nutritionally there are one it is prominent the characteristics of, it
Omega-fatty acid content be higher than people and plant.Omega-fatty acid can inhibit the absorption of human body solid acid to courage, reduce blood courage and consolidate
Determining alcohol improves vessel wall elasticity, highly advantageous to prevention and cure of cardiovascular disease.The component of composition as reparation striae of pregnancy, this
The purslane of embodiment refers to the whole strain of purslane, its active ingredient is extracted using alcohol extraction procedure.A reality wherein
It applies in example, purslane is 25 parts~50 parts, further preferably 30 parts~50 parts.
In one of the embodiments, including 8 parts~14 parts of alligator oil, 1.5 parts~3 parts of tocopherol, 50 parts~120
The hamamelis and 25 parts~50 parts of purslane of part.
In one of the embodiments, including 10 parts~13 parts of alligator oil, 2 parts~3 parts of tocopherol, 55 parts~120
The hamamelis and 30 parts~50 parts of purslane of part.
Alligator oil, tocopherol, hamamelis extract and purslane extract, each component mutual cooperation can promote skin
Fibroblastic a large amount of proliferation of skin, so as to promote to secrete clostridiopetidase A, activation periphery cell, the reconstruction work(for completing cell tissue
Can, it gradually fills up, substitute the impaired elastic fibers cell tissue of fracture.The composition of above-mentioned reparation striae of pregnancy can repair skin
Epidermis, skin corium and subcutaneous fat.The work that the composition of above-mentioned reparation striae of pregnancy also has antibacterial anti-inflammatory, boosts metabolism
With, it is experimentally verified that, it is good for the repairing effect of striae of pregnancy.
In one of the embodiments, in terms of mass fraction, the composition for repairing striae of pregnancy further includes 1 part~2.5 parts
Cetearyl glucoside.Cetearyl glucoside has excellent decontamination, foaming, foam stabilizing, emulsification, dispersion, solubilized energy
Power, acid and alkali-resistance is insensitive to electrolyte, can reduce other surfaces activating agent irritation and skin compatibility it is good.This implementation
Cetearyl glucoside is purchased from new east station of Guangzhou continuous heavy rain Chemical Co., Ltd. in mode, is milky white granules.
In one of the embodiments, cetearyl glucoside be 1.5 parts~2.5 parts, further preferably 2 parts~
2.5 part.
In one of the embodiments, in terms of mass fraction, the composition for repairing striae of pregnancy further includes 3 parts~8 parts of fourth
Glycol.Butanediol includes 1,2- butanediols, 1,3 butylene glycol and 1,4- butanediols.1,3 butylene glycol can be used as cosmetic humectant
And solvent, while also have certain bacteriostasis, can as medicine, pesticide, other fine chemicals raw materials for production.This implementation
Butanediol in mode is 1,3-BDO, is purchased from Guangzhou Heng Tao trade Co., Ltds.
Butanediol is 4 parts~8 parts, further preferably 5 parts~8 parts in one of the embodiments,.
In one of the embodiments, in terms of mass fraction, the composition for repairing striae of pregnancy further includes 3 parts~8 parts sweet
Oleostearin acid esters.Oil phase and the raw material of water phase can be well merged by stearine as emulsifier.This reality
It applies the stearine in mode and is purchased from new east station of Guangzhou continuous heavy rain Chemical Co., Ltd., be white particle.
Stearine is 4 parts~8 parts, further preferably 5 parts~8 parts in one of the embodiments,.
In one of the embodiments, in terms of mass fraction, repair the composition of striae of pregnancy raw material further include 1.5 parts~
4 parts of Butyrospermum parkii fruit fat.The fruit of butter fruit is a kind of very high fruit of nutritive value, containing multivitamin, abundant fat
The elements such as the sodium of fat acid and protein and high-content, potassium, magnesium, calcium, nutritive value can match in excellence or beauty with cream.The benevolence of butter fruit is rich in
Fat, for important edible oil and important work mining oil, and can margarine and soap processed.Butter fruit in present embodiment refers to
Butter fruit benevolence.Contain abundant unrighted acid, energy containing Butyrospermum parkii fruit fat, Butyrospermum parkii fruit fat in butter fruit benevolence
Enough strengthen the moisture-retaining capacity of skin, the skin that dry skin, that is, cutin is damaged can be moistened, while product can be adjusted
Mobility improves viscosity, improves the organoleptic quality of product and uses skin sense.The Butyrospermum parkii fruit ester of present embodiment is purchased from, pearl
Sea market Dodge Fine Chemical Co., Ltd
Butyrospermum parkii fruit fat is 2 parts~4 parts, further preferably 2.5 parts~4 parts in one of the embodiments,.
In one of the embodiments, in terms of mass fraction, the composition for repairing striae of pregnancy further includes 0.1 part~0.5 part
Allantoin.Allantoin is a kind of hydantoin derivatives, and allantoin, which has, promotes cell growth, accelerates wound healing, softening
The physiological functions such as keratoprotein are the good consolidant and antiulcer agents of skin trauma.Since allantoin is a kind of amphoterisation
Close object, can combine many kinds of substance formed double salt, have be protected from light, sterilization and anticorrosion, analgesic, antioxidation, can make skin holding water
Part, it moistens and soft, is the additive of the cosmetics such as cosmetology.Allantoin in present embodiment comes from Guangzhou hundred
Hao Bo Co., Ltds are white powder.
Allantoin is 0.2 part~0.5 part, further preferably 0.3 part~0.5 part in one of the embodiments,.
In one of the embodiments, in terms of mass fraction, the composition for repairing striae of pregnancy further includes 0.1 part~0.45 part
Carbomer.Carbomer is the high molecular polymer of acrylic acid key and allyl sucrose or pentaerythrite allyl ether, is a kind of non-
Often important rheology control agent, the carbomer after neutralization is outstanding gel-type vehicle, there is the important uses such as thickening, suspension, technique
Simply, stability is good, is widely used in lotion, cream, gel.Carbomer in present embodiment comes from the virtuous chemical industry of Guangzhou political affairs
Co., Ltd is white powder.
Carbomer is 0.2 part~0.45 part, further preferably 0.25 part~0.45 part in one of the embodiments,.
In one of the embodiments, in terms of mass fraction, the composition for repairing striae of pregnancy further includes 0.5 part~1.5 parts
Double hydroxy methylimidazole ureines.Double hydroxy methylimidazole ureines are a kind of preservatives, are mainly used for inhibiting the breeding of microorganism.
Double hydroxy methylimidazole ureines in present embodiment are white powder from Guangzhou Zheng Xian Chemical Co., Ltd.s.As reparation
The component of the composition of striae of pregnancy prevents product in shelf-life endometamorphism.
In one of the embodiments, double hydroxy methylimidazole ureines be 1 part~1.5 parts, further preferably 1.2 parts~
1.5 part.
In one of the embodiments, in terms of mass fraction, the composition for repairing striae of pregnancy further includes 1 part~3 parts of ore deposit
Fat.Vaseline is also referred to as vaseline, is the mixture of a kind of methane series hydrocarbon or saturated hydrocarbons semi liquid state, by being made after petroleum fractionating.Vaseline
State between solid and liquid, there is palm fibre, Huang, white three kinds of colors due to different purposes at room temperature.Vaseline is not hydrophilic, not yet
It can be absorbed, smearing can be formed on its surface a tunic on the skin, be not easy to evaporate moisture lost, and it is wet that can keep skin
Profit state stops the bacterium in air and skin contact, so as to reduce the possibility of infection.Vaseline in present embodiment
From Guangzhou Zheng Xian Chemical Co., Ltd.s, for white paste.
Vaseline is 1.5 parts~3 parts, further preferably 2 parts~3 parts in one of the embodiments,.
In one of the embodiments, in terms of mass fraction, the composition for repairing striae of pregnancy further includes 2 parts~9 parts sweet
Oil.Glycerine is also referred to as glycerine, be used as in terms of the medicine producing various preparations, solvent, hygroscopic agent, antifreezing agent, sweetener, outside ingredients
With ointment or suppository etc..Glycerine is industrial in papermaking, cosmetics, process hides, photograph, printing, intermetallic composite coating, electrical material and rubber etc.
In suffer from extensive purposes.Glycerine in present embodiment is clear gum liquid from Shenzhen Ke Ning Chemical Co., Ltd.s.
Glycerine is 4 parts~9 parts, further preferably 6 parts~9 parts in one of the embodiments,.
In one of the embodiments, in terms of mass fraction, repair the composition of striae of pregnancy raw material further include 10 parts~
18 parts of Jojoba seed.Jojoba (also known as Jojoba) is a kind of primary plant of Mexico, in the seed that Jojoba is tied
Jojoba seed oil has the characteristics that good permeability, heat safe.Jojoba seed oil also contains abundant vitamin D and protein, is
Moist and moisturizing oil well can keep skin water to moisten, and pre- anti-wrinkle and softening skin are usually used in face, body massage
And the maintenance of hair.
12 parts~18 parts of jojoba seed oil in one of the embodiments,.
In one of the embodiments, in terms of mass fraction, raw material include 5 parts~15 parts alligator oil, 1 part~3 parts
Tocopherol, 40 parts~120 parts of hamamelis and 20 parts~50 parts of purslane, 1 part~2.5 parts of cetearyl glucose
Glycosides, 3 parts~8 parts of butanediol, 3 parts~8 parts of stearine, 15 parts~40 parts of butter fruit number fruit fat, 0.1 part~
0.5 part of allantoin, 0.1 part~0.45 part of carbomer, 0.5 part~1.5 parts of double hydroxy methylimidazole ureines, 1 part~3 parts
Vaseline, 2 parts~9 parts of glycerine and 10 parts~18 parts of Jojoba seed.
In one of the embodiments, in terms of mass fraction, raw material include 8 parts~14 parts alligator oil, 1.5 parts~3 parts
Tocopherol, 50 parts~120 parts of hamamelis and 25 parts~50 parts of purslane, 1.5 parts~2.5 parts of cetearyl
Glucoside, 4 parts~8 parts of butanediol, 4 parts~8 parts of stearine, 2 parts~4 parts of Butyrospermum parkii fruit fat, 0.2 part~
0.5 part of allantoin, 0.2 part~0.45 part of carbomer, 1 part~1.5 parts of double hydroxy methylimidazole ureines, 1.5 parts~3 parts
Vaseline, 4 parts~9 parts of glycerine and 12 parts~18 parts of Jojoba seed.
In one of the embodiments, in terms of mass fraction, raw material include 10 parts~13 parts alligator oil, 2 parts~3 parts
Tocopherol, 60 parts~120 parts of hamamelis and 30 parts~50 parts of purslane, 2 parts~2.5 parts of cetearyl glucose
Glycosides, 5 parts~8 parts of butanediol, 5 parts~8 parts of stearine, 2.5 parts~4 parts of Butyrospermum parkii fruit fat, 0.3 part~
The carbomer of 0.5 part of 0.25 part~0.45 part of allantoin, 1.2 parts~1.5 parts of double hydroxy methylimidazole ureines, 2 parts~3 parts
Vaseline, 6 parts~9 parts of glycerine and 12 parts~18 parts of Jojoba seed.
The composition of the reparation striae of pregnancy of another embodiment is roughly the same with the composition of above-mentioned reparation striae of pregnancy, no
It is same to be, in terms of mass fraction, hamamelis is substituted using 2 parts~6 parts of hamamelis extracts, uses 1 part~2.5
The purslane extract of part substitutes purslane, and 1 part~1.8 parts of jojoba seed oils is used to substitute Jojoba seed.Hamamelis
Extract is purchased from Zhuhai City Dodge Fine Chemical Co., Ltd, and purslane extract is purchased from the limited public affairs of Zhuhai City Dodge fine chemistry industry
Department, jojoba seed oil are purchased from Guangzhou Zheng Xian Chemical Co., Ltd.s
In one of the embodiments, in terms of mass fraction, substituted using 2.5 parts~6 parts of hamamelis extracts
Hamamelis substitutes purslane using 1.5 parts~2.5 parts of purslane extracts, uses 1.5 parts~4 parts of Jojoba seed
Oil substitutes Jojoba seed.
In one of the embodiments, in terms of mass fraction, north is substituted using 3 parts~6 parts of hamamelis extracts
U.S. witch hazel substitutes purslane using 2 parts~2.5 parts of purslane extracts, uses 1.5 parts~1.8 parts of jojoba seed oil
Substitute Jojoba seed.
The composition of above-mentioned reparation striae of pregnancy, including alligator oil and various plants extract, each component mutual cooperation can
Promote fibroblastic a large amount of proliferation of skin, so as to promote to secrete clostridiopetidase A, activation periphery cell completes cell tissue
Reconstruction of The Function.Gradually fill up, substitute the impaired elastic fibers cell tissue of fracture, can repair the epidermis of skin, skin corium and
Subcutaneous fat.The composition of above-mentioned reparation striae of pregnancy also has antibacterial anti-inflammatory, antiallergic, moisturizing, moisturizing and boosts metabolism
Effect, and it is not added with any containing harmful substances such as hormone, heavy metals, product safety is experimentally verified that, for striae of pregnancy
Repairing effect is good.
The preparation method of the composition of above-mentioned reparation striae of pregnancy, includes the following steps：
S110, hamamelis extract, purslane extract, jojoba seed oil and Butyrospermum parkii fruit fat are prepared.
In one of the embodiments, using hamamelis as raw material, using water extracting method prepare hamamelis carry
Object is taken, specially：By 40 parts~120 part 80 mesh witch hazel powder and 100 DEG C of water according to mass ratio 1:5 ratios mix, and impregnate
It is filtered after 12 hours with 80 mesh screens, obtains hamamelis extract.
Using purslane as raw material, purslane extract is prepared using alcohol extraction procedure, specially：Dent is taken to look for hay
It 20 parts~50 parts, crushes, with refluxing extraction 2 times in a water bath of 800mL/L ethyl alcohol, is extracted for the first time with 80% ethyl alcohol of 10 times of amounts
2h, second of 80% ethyl alcohol with 8 times of amounts extract 1h, then filter, obtain purslane extract.
Using Jojoba seed as raw material, adopt supercritical carbon dioxide method for extracting prepare jojoba seed oil, specially：First will
10 parts~18 parts Jojoba seeds are ground into diameter≤0.05cm and crush bits；Then Jojoba seed is crushed into bits and puts dissolving pressure pan into
Pressure pan is closed in bottom；To liquefy CO2Liquefaction CO in tank2Equipressure is drained in dissolving pressure pan, and submergence Jojoba seed crushes
Stop drainage during bits, close drainage tube, temperature adjustment is to 40 DEG C~45 DEG C, pressure regulation 7Mpa, dissolution time 1 hour~2 hours；Then will
Mixed liquor in dissolving tank keeps pressure and temperature, flows through filter screen, isolates clarified solution；Clarified solution is drained into decompression tank,
Temperature is reduced to 10 DEG C~15 DEG C, recycling CO is drained in decompression2Gas is to recycling can, when gradual decompression drainage is to 1 atmospheric pressure
Close drainage tube；Obtain jojoba seed oil.
It should be noted that in above-mentioned raw materials, the mass fraction of hamamelis, purslane and Jojoba seed refers to doing
The mass fraction of product, certainly, in some embodiments, above-mentioned raw materials can also use fresh feed (i.e. water content it is higher,
Not fully drying raw material), as long as the parts by weight after guarantee is drying are the above-mentioned number enumerated.
In some embodiments, hamamelis extract, purslane extract are prepared respectively, certainly, in others
In embodiment, extract is prepared after can hamamelis be mixed with purslane.
It is understood that hamamelis extract, purslane extract, jojoba seed oil and Butyrospermum parkii fruit fat can
It buys, then step S110 can be omitted.Active ingredient in the hamamelis extract bought with according to above-mentioned steps system
Active ingredient in the hamamelis extract obtained is suitable.Active ingredient in the purslane extract bought with
It is suitable according to the active ingredient in purslane extract made from above-mentioned steps.Having in the jojoba seed oil bought
It is suitable with according to the active ingredient in jojoba seed oil made from above-mentioned steps to imitate ingredient.
S120, by allantoin, jojoba seed oil, butanediol, carbomer, glycerine, hamamelis extract and purslane
Extract is stirred, and obtains the first mixed liquor.
Specifically, allantoin is 0.1 part~0.5 part, jojoba seed oil is 1 part~1.8 parts, butanediol is 3 parts~8 parts,
Carbomer is 0.1 part~0.45 part, glycerine is 2 parts~9 parts, hamamelis extract is 2 parts~6 parts and purslane extract
It is 1 part~2.5 parts.
In one of the embodiments, after carbomer absorbs water bleach, it is stirred mixing.Further, stirring frequency
Rate is 20 revs/min~30 revs/min, and mixing time is 30min~45min.Further, it is risen after being uniformly mixed
Temperature obtains the first mixed liquor to 70 DEG C~75 DEG C.
Dipotassium glycyrrhizinate and allantoin, jojoba seed oil, butanediol, carbomer, sweet are added in one of the embodiments,
Oil, hamamelis extract and purslane extract stir together, the pH for being capable of regulation composition of dipotassium glycyrrhizinate so that
The composition pH of the reparation striae of pregnancy of preparation is between 5~7 so that product milder obtained does not stimulate.
S130, by alligator oil, cetearyl glucoside, stearine, vaseline, Butyrospermum parkii fruit fat and tocopherol
It is stirred, obtains the second mixed liquor.
Specifically, alligator oil is 5 parts~15 parts, cetearyl glucoside is 1 part~2.5 parts, stearine 3
Part~8 parts, vaseline are 1 part~3 parts, Butyrospermum parkii fruit fat is 1.5 parts~4 parts and tocopherol is 1 part~3 parts.
In one of the embodiments, stirring frequency be 20 revs/min~30 revs/min, mixing time for 30min~
45min.Further, 70 DEG C~75 DEG C are warming up to after being uniformly mixed, obtains the second mixed liquor.
S140, after being stirred the first mixed liquor and the second mixed liquor, obtain repairing the composition of striae of pregnancy.
In one of the embodiments, stirring frequency be 20 revs/min~30 revs/min, mixing time for 30min~
45min.After stirring evenly, homogeneous 20min~30min obtains the composition of reparation striae of pregnancy.
Specifically, after homogeneous, continue 70 DEG C~75 DEG C with 20 revs/min~30 revs/min insulated and stirred 30min~
45min obtains third mixed liquor.Further, after cooling stirring 20min~30min, in 35 DEG C~40 DEG C of third mixed liquor
The middle preservative for adding in 0.5 part~1.5 parts is stirred, and further, preservative is double hydroxy methylimidazole ureines, is stirred
Frequency is 20 revs/min~30 revs/min, and mixing time is 10min~20min.It prevents from bringing bubble into.
The method of the composition of above-mentioned reparation striae of pregnancy, raw material are easy to get, and preparation process is simple, to realize industrialization.
A kind of skin care item include the composition of above-mentioned reparation striae of pregnancy.
Of course, it should be understood that skin care item can also include the acceptable auxiliary material of skin care item.
Skin care item include moisturizer in one of the embodiments, and further, moisturizer is selected from hyaluronic acid, 1,3-
At least one of propylene glycol, saualane and 1,2- hexylene glycols.
Skin care item include thickener in one of the embodiments, and further, it is fine that thickener is selected from xanthans, crystallite
At least one of dimension element and sodium cellulose glycolate.
Skin care item include preservative in one of the embodiments, and further, preservative is selected from bis- (methylol) imidazoles
At least one of ureine, methyl hydroxybenzoate and Nipasol.
Skin care item include emulsifier in one of the embodiments, and emulsifier is selected from selected from glycerin monostearate, spermaceti
At least one of the smooth palmitate of stearyl alcohol, sorb and lanolin.
Certainly, skin care item can be aqua, emulsion, paste or tablet.
Above-mentioned skin care item being capable of maintenance striae of pregnancy.
A kind of drug, the composition of above-mentioned reparation striae of pregnancy.
Further, pharmacy acceptable auxiliary material is further included.
Said medicine can repair striae of pregnancy.
Specific embodiment
It is described in detail below in conjunction with specific embodiment.
Following embodiment, such as non-specified otherwise, then do not include the other components in addition to inevitable impurity.
In following embodiment, property of raw material is as follows：
Alligator oil, yellow oily liquid, purchased from Guangdong Hongyi Crocodile Industry Co., Ltd.；
Tocopherol, purchased from Zhuhai City Dodge Fine Chemical Co., Ltd；
Hamamelis extract, colourless transparent liquid, purchased from Zhuhai City Dodge Fine Chemical Co., Ltd；
Purslane extract, light yellow transparent liquid, Zhuhai City Dodge Fine Chemical Co., Ltd；
Cetearyl glucoside, milky white granules, new east station of Guangzhou continuous heavy rain Chemical Co., Ltd.；
Butanediol, transparency liquid, Guangzhou Heng Tao trade Co., Ltds；
Stearine, white particle are purchased from new east station of Guangzhou continuous heavy rain Chemical Co., Ltd.；
Butyrospermum parkii fruit fat JSJ0231, yellowish solid, Zhuhai City Dodge Fine Chemical Co., Ltd；
Allantoin, white powder, hundred Hao Bo Co., Ltds of Guangzhou；
Carbomer U20, white powder, Guangzhou Zheng Xian Chemical Co., Ltd.s；
Double hydroxy methylimidazole ureines, white powder, Guangzhou Zheng Xian Chemical Co., Ltd.s；
Vaseline, white lotion, Guangzhou Zheng Xian Chemical Co., Ltd.s；
Jojoba seed oil TX-153528, golden yellow liquid, Guangzhou Zheng Xian Chemical Co., Ltd.s.
The preparation parameter of Examples 1 to 5 is shown in Table 2, is as follows：
(1) weigh alligator oil, tocopherol, hamamelis extract, purslane extract, cetearyl glucoside,
Butanediol, stearine, Butyrospermum parkii fruit fat, allantoin, carbomer, double hydroxy methylimidazole ureines, vaseline, glycerine and
Jojoba seed oil, specific mass fraction are shown in Table 1.
(2) by allantoin, jojoba seed oil, butanediol, glycerine, carbomer U20, hamamelis extract, purslane
Extract is dissolved in 100 parts of water.
(3) it after card wave U20 absorbs water bleach, is stirred evenly with mixing speed S1, mixing time t1, then heats to T1
DEG C, using dipotassium glycyrrhizinate adjusting pH value to 6, the first mixed liquor is obtained, the first mixed liquor.
(4) by alligator oil, cetearyl glucoside, cetostearyl alcohol, stearine, vaseline, Butyrospermum parkii fruit
Fat and tocopherol are stirred evenly with mixing speed S2, mixing time t2, are then heated to T2 DEG C, are obtained the second mixed liquor.
(5) the first mixed liquor and the second mixed liquor are stirred with mixing speed S3, mixing time t3, then mean value
T4min keeps the temperature (T2 DEG C) stirring t5min with mixing speed S4, obtains crude product.
(6) crude product is cooled to T3 DEG C, double hydroxy methylimidazole ureines is added in, with mixing speed S4, mixing time
T6min is stirred, and must repair the composition of striae of pregnancy.
Table 1
Table 2
Comparative example 1
Preparation condition and parameter are substantially same as Example 4, and difference is, alligator oil is not added in step (4).
Comparative example 2
The composition for repairing striae of pregnancy is only alligator oil.
The composition of reparation striae of pregnancy that Examples 1 to 5 and comparative example 1~2 obtain is subjected to trial population.Trial population
When, the application method for repairing the composition of striae of pregnancy is：First cleaning skin of abdomen 2 minutes, then applies according to the range of striae of pregnancy
5g~10g products are smeared, are then gently massaged 10 minutes clockwise with finger.
Case 1：Mrs Zeng, childbirth terminate to begin to use the composition of the reparation striae of pregnancy of comparative example 1 after two weeks, use one
After a month, lines variation unobvious.
Case 2：Miss Wu, childbirth terminate to begin to use the reparation gestation of comparative example 2 according to above-mentioned application method after two weeks
The composition of line, after one month, lines variation unobvious.
Case 3：Mrs Lin, striae of pregnancy 2 years use the combination of the reparation striae of pregnancy of embodiment 1 according to above-mentioned application method
After two months, skin of abdomen becomes to compact flexible object, and striae of pregnancy significantly desalinates 33%.
Case 4：Mrs Deng, striae of pregnancy 4 years use the combination of the reparation striae of pregnancy of embodiment 1 according to above-mentioned application method
After two months, skin of abdomen becomes to compact flexible object, and striae of pregnancy significantly desalinates 30%.
Case 5：Mrs Feng, striae of pregnancy 3 years use the combination of the reparation striae of pregnancy of embodiment 2 according to above-mentioned application method
After object one month, lines significantly desalinates 30%.
Case 6：Company personnel Mrs Peng, striae of pregnancy 14 years use the reparation gestation of embodiment 2 according to above-mentioned application method
The composition of line is after four months, and skin of abdomen compacts flexible, and striae of pregnancy significantly desalinates 30%.
Case 7：Mrs Zhu, striae of pregnancy 1 year, according to above-mentioned application method make embodiment 3 reparation striae of pregnancy composition
After two months, skin of abdomen becomes to compact flexible, and striae of pregnancy significantly desalinates 44%.
Case 8：Mrs Xu, after childbirth terminates three months, the reparation for beginning to use embodiment 3 according to above-mentioned application method is pregnant
It is pregnent the composition of line, after one month, lines significantly desalinates 45%.
Case 9：Mrs Wang, striae of pregnancy 1 year use the combination of the reparation striae of pregnancy of embodiment 4 according to above-mentioned application method
After object 1 one months, lines significantly desalinates 40%.
Case 10：Mrs Zhou after childbirth terminates one month, starts to use the reparation of embodiment 4 according to above-mentioned application method
The composition of striae of pregnancy, after one month, lines significantly desalinates 45%.
Case 11：Mrs Zhi, childbirth terminate after two weeks, to start pregnant using the reparation of embodiment 5 according to above-mentioned application method
It is pregnent the composition of line, after one month, lines significantly desalinates 50%.
Case 12：Mrs Chen after childbirth terminates three months, starts to use the reparation of embodiment 5 according to above-mentioned application method
The composition of striae of pregnancy, after one month, lines significantly desalinates 50%.
Case 13：Mrs Qin, childbirth terminate after two weeks, to start pregnant using the reparation of embodiment 6 according to above-mentioned application method
It is pregnent the composition of line, after one month, lines significantly desalinates 27%.
Each technical characteristic of embodiment described above can be combined arbitrarily, to make description succinct, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, it is all considered to be the range of this specification record.
Embodiment described above only expresses the several embodiments of the present invention, and description is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that those of ordinary skill in the art are come
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention
Range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. a kind of composition for repairing striae of pregnancy, which is characterized in that in terms of mass fraction, raw material includes：
5 parts~15 parts of alligator oil, 1 part~3 parts of tocopherol, 40 parts~120 parts of hamamelis and 20 parts~50 parts
Purslane.
2. the composition according to claim 1 for repairing striae of pregnancy, which is characterized in that in terms of mass fraction, raw material also wraps
It includes：
1 part~2.5 parts of cetearyl glucoside, 3 parts~8 parts of butanediol, 3 parts~8 parts of stearine, 1.5
Part~4 parts of Butyrospermum parkii fruit fat, 0.1 part~0.5 part of allantoin, 0.1 part~0.45 part of carbomer, 0.5 part~1.5 parts
Double hydroxy methylimidazole ureines, 1 part~3 parts of vaseline, in 2 parts~9 parts of glycerine and 10 parts~18 parts of Jojoba seed
It is at least one.
3. a kind of composition for repairing striae of pregnancy, which is characterized in that in terms of mass fraction, the alligator oil including 5 parts~15 parts, 1
Part~3 parts of tocopherol, 2 parts~6 parts of hamamelis extract, 1 part~2.5 parts of purslane extract.
4. the composition according to claim 3 for repairing striae of pregnancy, which is characterized in that in terms of mass fraction, further include 1 part
~2.5 parts of cetearyl glucoside, 3 parts~8 parts of butanediol, 3 parts~8 parts of stearine, 1.5 parts~4 parts
Butyrospermum parkii fruit fat, 0.1 part~0.5 part of allantoin, 0.1 part~0.45 part of carbomer, 0.5 part~1.5 parts of double hydroxyls
At least one in methylimidazolidinyl urea, 1 part~3 parts of vaseline, 2 parts~9 parts glycerine and 1 part~1.8 parts of jojoba seed oil
Kind.
5. the preparation method of the composition of striae of pregnancy is repaired as claimed in claim 4, which is characterized in that include the following steps：
By the allantoin, the jojoba seed oil, the butanediol, the carbomer, the glycerine, the hamamelis
Extract and the purslane extract are stirred, and obtain the first mixed liquor；
By the alligator oil, the cetearyl glucoside, the stearine, the vaseline, the Butyrospermum parkii
Fruit fat and the tocopherol are stirred, and obtain the second mixed liquor；
After first mixed liquor and second mixed liquor are stirred, double hydroxy methylimidazole ureine stirrings are added in
Mixing obtains the composition for repairing striae of pregnancy.
6. Claims 1 to 4 any one of them repairs the composition of striae of pregnancy in skin care item or the medicine of preparation reparation striae of pregnancy
Application in object.
7. a kind of skin care item repair the composition of striae of pregnancy including Claims 1 to 4 any one of them.
8. skin care item according to claim 7, which is characterized in that the skin care item are aqua, emulsion, paste or tablet.
9. skin care item according to claim 7, which is characterized in that further include the acceptable auxiliary material of skin care item, the skin care
The acceptable auxiliary material of product is selected from least one of moisturizer, thickener and emulsifier；
The moisturizer is selected from least one of hyaluronic acid, 1,3- propylene glycol, saualane and 1,2- hexylene glycols；
The thickener is selected from least one of xanthans, microcrystalline cellulose and sodium cellulose glycolate；
The emulsifier in glycerin monostearate, cetostearyl alcohol, the smooth palmitate of sorb and lanolin at least one
Kind.
10. a kind of drug repairs the composition of striae of pregnancy including Claims 1 to 4 any one of them.
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| CN109568152A (en) * | 2018-12-30 | 2019-04-05 | 艾因特丽（苏州）生物科技有限公司 | A kind of compound gel preparation and preparation method thereof for repairing striae of pregnancy |
| CN110179126A (en) * | 2019-05-29 | 2019-08-30 | 山东腾贵医药有限公司 | A kind of post-operative recovery preparation and preparation method thereof |
| CN112057388A (en) * | 2020-10-15 | 2020-12-11 | 广东美赛尔细胞生物科技有限公司 | Cream for striae gravidarum repair and preparation method thereof |
| CN114533584A (en) * | 2022-04-21 | 2022-05-27 | 加来(济南)生活科技有限公司 | Collagenase anti-wrinkle face cream |
| CN115317526A (en) * | 2022-06-22 | 2022-11-11 | 浙江工业大学 | Bacteriostatic emulsion for treating tinea pedis and preparation method thereof |
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