CN102488848A

CN102488848A - Traditional Chinese medicine composition used for treating high-pathogenicity porcine reproductive and respiratory syndrome, preparation method thereof, and application thereof

Info

Publication number: CN102488848A
Application number: CN2011104274223A
Authority: CN
Inventors: 郝智慧; 曲宝涵
Original assignee: Qingdao Agricultural University
Current assignee: Qingdao Agricultural University
Priority date: 2011-12-20
Filing date: 2011-12-20
Publication date: 2012-06-13
Anticipated expiration: 2031-12-20
Also published as: CN102488848B

Abstract

The invention provides a traditional Chinese medicine composition used for preventing and treating high-pathogenicity porcine reproductive and respiratory syndrome (PPRS). The composition comprises common anemarrhena, gypsum, snakegourd root, common lophatherum herb, reed rhizome, honeysuckle flower, Baikal skullcap root, red peony root, lanceolate dichotomous starwort root, ligusticum, sanna leaf, pilose asiabell root, and Mongolian milkvetch root. According to the invention, when the high-pathogenicity PPRS is treated by using the traditional Chinese medicine composition, the medicine composition is advantaged in substantial treatment effect, high curative rate, no toxic or side-effect, low reoccurrence rate, no drug induced suffering, and low cost. With the traditional Chinese medicine composition, both root causes and symptoms can be treated, and the meat quality satisfies a standard of commodity inspections.

Description

Chinese medicine composition, method for preparing and the application of treatment highly pathogenic PRRS

Technical field

The present invention relates to the herbal medicine technical field, relate in particular to a kind of Chinese medicine composition that is used to prevent and treat highly pathogenic PRRS.

Background technology

It is a major industry of China's animal husbandry development that ecological pig produces; It also is a main pillar of China's livestock products foreign exchange earning; Be aspect increasing national income and uplifting the people's living standard, accelerate the farming and animal husbandry development, the important goal of aspects such as adjustment agriculture industrialization structure.

" highly pathogenic PRRS " claimed " hyperpyrexia disease " again, and being has the high lethal eqpidemic disease of a kind of polarity that causes by pig breeding and breathing syndrome poison variant, after nineteen ninety-five is imported China into; Caused bigger several times popularly in China, especially since 2006, " highly pathogenic PRRS " that reproductive and respiratory syndrome variation strain causes (claiming " hyperpyrexia disease " again) take place with popular at China's southern area; Most of hog area then affects the whole country rapidly; Its oncoming force is suddenly, loss is big, and is historical rare, causes tens thousand of pig death; Economic loss is huge, numerous medium and small enterprise so breaks of raising pigs.

" highly pathogenic PRRS " is immunosuppressive disease, and swinery infects this after being ill, the main infringement of virus macrophage; Can damage collective's immune function, cause the immunosuppressant of pig, cause immunne response slow; Make very easily supervention various diseases of disease pig, this disease has the characteristics of " three-hypers one is low ", and promptly fever, sickness rate are high, mortality rate is high, cure rate is low; Most of morbidity pig farm sickness rate is more than 50%, and mortality rate is up to 50%～90%, and prevention and treatment be the ten minutes difficulty all.

" highly pathogenic PRRS " is a kind of height contagious disease; Ill pig be the main source of infection of this disease with malicious pig; Main route of transmission is that contact infection, air borne and seminal fluid are propagated; Also can pass through the Placenta Hominis vertical transmission, but number of ways such as susceptible pig trans-oral, nasal cavity, muscle, vein and intrauterine inoculation and infective virus, and 2～14 weeks can give other susceptible pigs with viral communication behind the pig infective virus through contact.

The cardinal symptom of suffering from the pig of " highly pathogenic PRRS " has: body temperature obviously raises, and sickness rate is high, skin rubefaction, and later stage limb end, the inferior place of abdomen are blue; The inflammation of eye conjunctiva, blepharoedema; Cough, asthma, dyspnea, the later stage is ventral breathing; Part pig rear quarters is unable, can not stand or occur nervous symptoms such as ataxia; Stool is normal or have loose bowels, or does and rarely alternately indivedual pig intractable diarrheas are arranged also, the urine jaundice, and the later stage is brownish red; Sow miscarriage occurs, produces stillborn fetus, weak tire or mummy tire.

At present; " highly pathogenic PRRS " adopts the mode of vaccine injection to prevent and treat, and common have disinfectant such as aldehydes, chlorine-containing disinfectant, phenols, oxidant, compound iodine preparation, bases to kill the virus of this disease or adopt injection such as antiviral interferon, penicillin, spectinomycin, oxytetracycline to treat should disease, slow but vaccine produces immunity; And keep immunity time weak point; Toxic and side effects is big, and existing Chinese medicine preparation effect is undesirable, and treatment is slow; The course of treatment is long, and cure rate is low.

Summary of the invention

Technical problem to be solved by this invention is to be to provide a kind of novel being used to prevent and treat Chinese medicine composition of highly pathogenic PRRS and preparation method thereof, and it is evident in efficacy to adopt this Chinese medicine composition that the prevention of the pig that suffers from highly pathogenic PRRS and treatment are had, treating both the principal and secondary aspects of a disease; Cure rate is high; Have no side effect, be difficult for recurrence, no poisoning; Cost is low, and meat does not have the advantages such as melancholy of commodity inspection.

In order to solve the problems of the technologies described above; The invention provides a kind of Chinese medicine composition that is used to prevent and treat highly pathogenic PRRS, it comprises: the Rhizoma Anemarrhenae, Gypsum Fibrosum, Radix Trichosanthis, Herba Lophatheri, Rhizoma Phragmitis, Flos Lonicerae, Radix Scutellariae, Radix Paeoniae Rubra, Radix Stellariae, Radix Angelicae Sinensis, Folium Sennae, Radix Codonopsis and the Radix Astragali.

Wherein, The ratio of weight and number of each component in the said Chinese medicine composition is the said Rhizoma Anemarrhenae 50～60 weight portions, said Gypsum Fibrosum 30～35 weight portions, said Radix Trichosanthis 15～20 weight portions, said Herba Lophatheri 15～20 weight portions, said Rhizoma Phragmitis 15～20 weight portions, said Flos Lonicerae 10～15 weight portions, said Radix Scutellariae 20～25 weight portions, said Radix Paeoniae Rubra 10～15 weight portions, said Radix Stellariae 10～15 weight portions, said Radix Angelicae Sinensis 20～25 weight portions, said Folium Sennae 10～15 weight portions, said Radix Codonopsis 20～25 weight portions and the said Radix Astragali 20～25 weight portions.

Wherein, the said Chinese medicine composition that is used for treating highly pathogenic PRRS can also comprise Semen Cuscutae, and the ratio of weight and number of said Semen Cuscutae in said Chinese medicine composition is Semen Cuscutae 10～20 weight portions.

Wherein, The said Chinese medicine composition that is used for treating highly pathogenic PRRS can also comprise Fructus Crataegi, Pericarpium Citri Reticulatae Viride and Fructus Oryzae Germinatus; Said Fructus Crataegi, Pericarpium Citri Reticulatae Viride, the ratio of weight and number of Fructus Oryzae Germinatus in said Chinese medicine composition are Fructus Crataegi 3～5 weight portions, Pericarpium Citri Reticulatae Viride 3～5 weight portions and Fructus Oryzae Germinatus 3～5 weight portions.

Wherein, the said Chinese medicine composition that is used for treating highly pathogenic PRRS can also comprise Radix Glycyrrhizae, and the ratio of weight and number of said Radix Glycyrrhizae in said Chinese medicine composition is Radix Glycyrrhizae 5～10 weight portions.

Wherein, the said Chinese medicine composition that is used for treating highly pathogenic PRRS can also comprise Colla Corii Asini, and the ratio of weight and number of said Colla Corii Asini in said Chinese medicine composition is Colla Corii Asini 5～10 weight portions.

For solving the problems of the technologies described above, the present invention also provides a kind of Chinese medicine composition that is used to treat highly pathogenic PRRS, and said Chinese medicine composition is prepared from through following method:

The first step is packed the Rhizoma Anemarrhenae in the multi-function extractor into, adds alcohol heating reflux and extracts merge extractive liquid; Centrifugal, filter, obtain filtrate; Concentrating under reduced pressure reclaims ethanol, obtains extractum, with the extractum stored refrigerated; Get in the spray dryer dryly subsequently, pulverize and sieve with pulverizer, obtaining granularity is 50～100 purpose Common Anemarrhena Rhizomes;

Second step, Gypsum Fibrosum to be pulverized, decocte with water 2～4 times merges decoction liquor, filters, and static spending the night extracted the upper strata stillness of night, and concentrating under reduced pressure removes and anhydrates, and is dried to dried cream, pulverizes and sieves with pulverizer, and obtaining granularity is 100～150 purpose gypsum powders;

The 3rd step, Radix Trichosanthis, Herba Lophatheri, Rhizoma Phragmitis, Flos Lonicerae, Radix Scutellariae, Radix Paeoniae Rubra, Radix Stellariae and Folium Sennae are mixed, put into marmite and fry into charcoal, be ground into smalls with pulverizer, sieve, obtaining granularity is 100～200 purpose powder;

The 4th step, Radix Angelicae Sinensis, Radix Codonopsis and the Radix Astragali are distinguished decocte with water 2～4 times, merge decoction liquor separately, filter; Static spending the night extracted the upper strata stillness of night, and concentrating under reduced pressure removes and anhydrates; Be dried to dried cream respectively, pulverize and sieve, obtain 70～120 purpose Chinese Angelica Roots, Radix Codonopsis powder and Radix Astragali powder;

In the 5th step,, obtain said Chinese medicine composition with being stirred to evenly under the normal temperature and pressure conditions in the above-mentioned powder input blender.

For solving the problems of the technologies described above, the present invention also provides the method for preparing of above-mentioned Chinese medicine composition, and it comprises:

For solving the problems of the technologies described above, the present invention also provides a kind of fodder compound, and it comprises: comprise above-mentioned Chinese medicine composition and feed vector as additive.

Wherein, can also comprise in the said fodder compound that hemicellulase, colloid, ammonium sulfate, sodium carbonate, sodium bicarbonate, carrageenan and maltodextrin are as the additive except that Chinese medicine composition.

For solving the problems of the technologies described above, the present invention also provides above-mentioned Chinese medicine composition to be used for preventing and treating the application of the medicine of highly pathogenic PRRS in preparation.

Beneficial effect of the present invention:

With respect to the medicine that is used to prevent and treat highly pathogenic PRRS of the prior art, it is evident in efficacy that the present invention adopts this Chinese medicine composition that the prevention of highly pathogenic PRRS and treatment are had, treating both the principal and secondary aspects of a disease; Cure rate is high; Have no side effect, be difficult for recurrence, no poisoning; Cost is low, and meat does not have the advantages such as melancholy of commodity inspection.

The specific embodiment

Chinese veterinarian's theory thinks that " highly pathogenic PRRS " belongs to Epidemic Febrile Disease, is that gas heat is flourishing, damp and hot accumulate long-pending, in force blood system; Pyretic toxicity is gone into to defend and is abandoned due to the nutrient blood, and causes the time of intense heat in both QI and blood systems, and pathogenic fire is for suffering from; With regard to concrete symptom: on the burning hot inflammation, then the eye conjunctiva is rubescent, and eye discharge increases; Pathogenic heat are invaded edema caused by disorder of QI, hyperpyrexia then, and extreme thirst, skin is scorching hot; Pyretic toxicity is invaded pericardium, disturbs and the mind, and is then drowsiness, and spirit is depressed.Along with the state of an illness is goed deep into accumulateing in the pyretic toxicity, the invasion and attack blood system, it is blue skin rubefaction then to occur, and pore is hemorrhage, the symptom of bleeding due to blood-heaies such as skin many places purpura.

The pathogeny of highly pathogenic PRRS is: body's immunity weakens or pig is poisoned in forfeiture, toxin behind the pig infective virus lymphsystem, cardiac function descend, and let pig lose rejection ability and homergy, continue to infect bodies for other antigens and make chance; Cause of flaccid muscles, female animal miscarriage, raising livestock exclusively for meat production proctoptosis; Gastrointestinal, endocrine, maladjusted nervous system; Cell tissue amine discharges to be increased, and immunocyte, phagocytic function descend, and can't drain after the death.Cause body at full capacity, most of drug use has increased burden to organism metabolism, quickens dead.

According to above-mentioned theory; The invention provides a kind of like this Chinese medicine composition that is used to prevent and treat highly pathogenic PRRS, it comprises: the Rhizoma Anemarrhenae, Gypsum Fibrosum, Radix Trichosanthis, Herba Lophatheri, Rhizoma Phragmitis, Flos Lonicerae, Radix Scutellariae, Radix Paeoniae Rubra, Radix Stellariae, Radix Angelicae Sinensis, Folium Sennae, Radix Codonopsis and the Radix Astragali.

The Rhizoma Anemarrhenae: be plant amedica, bitter in the mouth, sweet, cold in nature, go into lung, stomach, kidney channel, the relieving restlessness of purging heat is arranged, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough cures mainly fever caused by exogenous pathogenic factors, and hyperpyrexia is irritated, lung-heat type cough, interior-heat symptom such as quench one's thirst; Its bitter cold matter profit, the property sedimentation can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and goes into edema caused by disorder of QI, the intenseness of heat impairment of body fluid; Also be used to treat diabetes; Phlegm-heat obstructing in the lung and breathing heavily, the xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, symptoms such as hyperactivity of deficient fire, the Rhizoma Anemarrhenae has inhibitory action to various bacteria such as dysentery bacterium, Bacillus typhi, escherichia coli, Bacillus proteus, staphylococcus, streptococcus.

Radix Trichosanthis: i.e. Radix Trichosanthis, sweet in the mouth, little hardship, lung, stomach warp are gone in property acid, cold, and clearing away heat and promoting production of body fluid is arranged, moistening the lung and resolving the phlegm, the effect of detumescence and apocenosis is mainly used in the excessive thirst of consumption of body fluid caused by febrile disease, diabetes, cough caused by dryness-heat, symptoms such as carbuncle sore tumefacting virus.

The Rhizoma Anemarrhenae and Radix Trichosanthis are united use can the lung heat clearing sthenia gastropyrexia and promoting the production of body fluid to quench thirst, treats the symptoms such as dry mouth and tougue of consumption of body fluid caused by febrile disease, the treatment diabetes.

Rhizoma Phragmitis: sweet in the mouth, cold in nature, go into lung, stomach warp, the lung heat clearing gastric heat is arranged, diuresis, the dissipating depression of QI clearing away phlegm, the effect of YIN nourishing and the production of body fluid promoting, it is thirsty to be mainly used in the join the army dysphoria with smothery sensation of branch of treatment epidemic febrile disease, and dryness of the tongue Tianjin is few; The rash of measles goes out not pass through, and pathogenic heat is violated the cough and expectoration of lung; The cough vomiting pus of lung abscess; The damp and hot symptoms such as vomiting singultus that block in stomach.

The sweet cold light weight of Rhizoma Phragmitis, the heat of kind lung heat clearing stomach and hold concurrently to pass through and loose is treated fever caused by exogenous pathogenic factors initial stage exterior syndrome, mid-term hyperpyrexia excessive thirst, the later stage the moon of bringing down a fever of holding concurrently and is hindered excessive thirst.

Gypsum Fibrosum: acrid in the mouth, sweet, property Great Cold, go into lung, stomach warp; Clearing away heat-fire is arranged, the effect of the relieving restlessness of quenching the thirst; Its abnormal smells from the patient is all thin and matter is heavy, excess-heat that can the removing summer-heat stomach of foot Yang Ming, the treatment pathogen invading YANG MING fill the air symptoms such as hyperpyrexia, profuse sweating, thirsty, vexed, arteries and veins flood; Key medicine for the bright stomach warp of sun; Hyperpyrexia to due to epidemic encephalitis, encephalitis b, the pneumonia etc. has antipyretic effect preferably, and has relieving convulsion effect concurrently, also can be used for the symptoms such as pyretic arthralgia of burning pain in the epigastrium, headache, aphtha of the mouth and tongue and heat-damp in summer dysphoria with smothery sensation, lung-heat cough with asthma, the restlessness and thirst due to the high Sheng of stomach-fire, damp and hot obstruction of meridian, arthralgia.

Herba Lophatheri: have another name called Folium Bambusae, sweet in the mouth, light, cold in nature, go into the heart, lung, small intestine meridian, clearing away heart-fire and clear small intestine fire are arranged, analgesic relieving restlessness, diuretic quenches the thirst, and the effect of preventing phlegm from forming and stopping coughing is mainly used in the epidemic febrile disease restlessness and thirst, and the remnant pathogenic heat being not dispelled is to dysphoria and insomnia; The aphtha of the mouth and tongue of flaming up of heart-fire; Heat in the heart moves symptoms such as difficulty and pain in micturition in small intestinal, excessive thirst, and staphylococcus aureus and bacillus pyocyaneus are had inhibitory action.

Gypsum Fibrosum and Folium Bambusae share, the effect that has clearing away heat-fire, relieving restlessness to quench the thirst, and treating heart stomach has heat, or calentura later stage waste heat is not to the greatest extent to thirsty agitation.

The Gypsum Fibrosum and the Rhizoma Anemarrhenae all can clear eliminating the pathogens from the lung excess of the stomach fire, and Gypsum Fibrosum is a mineral drug, and pathogenic fire reducing power is strong, expelling pathogenic factors from muscles heat and rush down positive bright stomach-fire; Focus on cleaning, use the Gypsum Fibrosum prevention separately and treat pig, because Gypsum Fibrosum is hot cold, though use the effectively treatment high-pathogenicity blue ear disease of ability in a large number with high-pathogenicity blue ear disease; But cause very big injury can for the taste of pig, and Gypsum Fibrosum is not good for the therapeutic effect of the ill pig that is in the high-pathogenicity blue ear disease later stage, and the Rhizoma Anemarrhenae is a plant amedica; The double kidney channel of returning of matter profit focuses on clearly and grows, again can nourshing Yin and drynsessmoistening prescription logical intestinal; The removing the relative excess fire can be moisturized again, and Gypsum Fibrosum and Rhizoma Anemarrhenae mutual reinforcement between are usefulness, and the power of removing summer-heat excess-heat significantly strengthens; Because of not only pathogenic fire purging but also grow dryness of the stomach, so, calentura mid-term, later stage heresy are gone into edema caused by disorder of QI though big hardship does not also have the anxiety of imapirment of the spleen and stomach Great Cold; Excess-heat is flourishing, the excessive thirst taking fluids profusely, and the flushed complexion arteries and veins is red etc., and symptom has extraordinary curative effect.

Flos Lonicerae: have another name called Flos Lonicerae, Flos Lonicerae, Flos Lonicerae, two precious flowers, sweet in the mouth, cold in nature is gone into the heart, lung, stomach, large intestine channel; The effect of heat-clearing and toxic substances removing is arranged; Holding concurrently can eliminating pathogenic heat from blood to cure dysentery, is mainly used in affection due to external wind and heat, the epidemic febrile disease pyretic toxicity is contained, or epidemic febrile disease is from the beginning of pathogenic heat still at the part of the body cavity above the diaphragm housing the heart and lungs and when not descending; Pyretic toxicity dysentery, stool hematochezia; The fever disease in summer card; The carbuncle sore that pyretic toxicity gathers is from the beginning of the ， inflammation heat person of swelling and ache, and other skin infections, and this thing has antipyretic effect preferably, and antiinflammatory action is arranged, and can promote leukocytic phagocytic function, and multiple pyococcus and pathogenic entero becteria are had stronger bacteriostasis.

Radix Angelicae Sinensis: sweet in the mouth, suffering, warm in nature, go into liver, the heart, spleen channel, enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation is mainly used in having a dizzy spell of deficiency of heart-blood, fatigue and weakness, shortness of breath and palpitation, and other syndrome of deficiency of blood; The sea of blood is hollow, the menoxenia of the cold and deficiency of CHONG and REN meridians or congestion retardance, dysmenorrhoea; Produce or stomachache, and other blood stasis are had a pain and the symptoms such as constipation of deficiency of YIN insufficiency of blood dryness of the intestine, its can improve the uterus blood circulation, alleviate pelvic congestion; Relieving dysmenorrhea, in addition, the immunity that Radix Angelicae Sinensis can enhancing body.

Radix Angelicae Sinensis has the effect of removing blood stasis and activating blood flow analgesic, and Flos Lonicerae cooperates with it, and one walks edema caused by disorder of QI; One walks blood system; QI and blood is ruled together, and both can fall the heat in the lung clearly, and clearing heat in QI system divides the merit that removing heat from blood is held concurrently in stagnated fire again; Walk to detoxify altogether dissipating blood stasis, let out and stop up logical stagnant merit, be used to treat pyretic toxicity and stop up the skin ulcer of the blood vessels that stagnate and swell from the beginning of symptoms such as swelling pains.

Radix Scutellariae: bitter in the mouth, cold in nature, go into the heart, lung, stomach, gallbladder, large intestine channel, heat clearing and damp drying is arranged, eliminating fire and detoxication, antiabortive, the hemostatic effect is mainly used in diarrhoea, dysentery, jaundice, pyretic stranguria due to damp and hot; The cough due to lung-heat, thirsty pharyngalgia also can be used for excessive fetal movement due to heat in pregnancy, and the pyretic toxicity pathogenic fire is invaded the swollen card of carbuncle sore poison of excessive skin.

Radix Paeoniae Rubra: bitter in the mouth, little hardship, go into Liver Channel, removing fire from the liver is arranged, clearing away heat and cooling blood, the effect of stasis-dispelling and pain-killing is mainly used in the vigorous conjunctival congestion and swelling pain of liver-fire, has a dizzy spell, pain in chest and hypochondrium, the fever of the body crimson tongue of the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, macule is hemorrhage, and the blood stasis amenorrhea; The haematemesis hematuria of the absurd row of burning hot flourishing forcing blood; The trip of women's heat in blood is through too much; Blood is capable to block caused various pain; The symptoms such as furuncle carbuncle of heat in blood poison Sheng.

Radix Stellariae: sweet in the mouth, be slightly cold, go into liver, stomach warp, useful kidney yin, reducing the asthenic fever, the strengthening the spleen stomach, the effect of the infantile malnutrition that disappears is mainly used in interior-heat caused by deficiency of YIN, night sweat spontaneous perspiration, hectic fever due to YIN-deficiency consumptive fever and infantile malnutrition, symptoms such as dry thirsty dry urgency

Folium Sennae: sweet in the mouth, hardship, cold in nature, go into large intestine channel, purging heat to relax the bowels is arranged, the stagnate merit of diuretic of row is mainly used in the constipation of the stagnant the intestines and stomach of accumulation of heat, the abdominal distention abdominal distention of accumulation of food in the stomach and intes tine due to indigestion, symptoms such as anorexia.

The Radix Astragali: sweet in the mouth, warm in nature, return lung, spleen channel, tonification spleen soil is arranged, the elevate a turnable ladder yang-energy; Strengthening superficial resistance to stop perspiration, effects such as holder skin ulcer granulation promoting are mainly used in the weak anorexia and loose stool due to the treatment deficiency of both the splenic and pulmonary QI, shortness of breath and palpitation; The visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, the chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency; Insufficiency of vital energy and blood, yang-energy skin infection on the decline do not rise, difficulty in discharging of pus, burst and not hold back for a long time; And the deficiency of vital energy is lost the edema of fortune; symptoms such as dysuria; the Radix Astragali has dual regulation to animal blood glucose, can increase anemia person's erythrocyte and hemoglobin, promotes leukocyte and thrombocytopenia person to recover normal; and can improve or recover erythrocytic function, can improve the non-specific immunity of body.。

Radix Codonopsis: sweet in the mouth, property is flat, goes into lung, spleen channel, and the QI invigorating strengthening the spleen is arranged; The effect of nourishing blood to promote the production of body fluid, be mainly used in deficiency of both the splenic and pulmonary QI or QI and blood deficiency fatigue and weakness, breathe hard, symptom such as cough spontaneous perspiration etc., Radix Codonopsis is longer than the spleen reinforcing nourishing the stomach; Transfer regulating the function of middle-JIAO, have the effect of nourishing blood concurrently, its property is flat, spleen invigorating fortune and not dry; Flavour is cloudy and not wet, can improve modulation on immune status, and disease resistance enhancemen, facilitating digestion absorb, and improve metabolism, promote the absorption of intestinal to nutrient substance.

The drug action mechanism of Chinese medicine composition of the present invention is following: the Rhizoma Anemarrhenae and Gypsum Fibrosum are reused, and are mainly used in the fire of eliminating the pathogens from the lung excess of the stomach clearly, the excess-heat of main clear positive bright edema caused by disorder of QI; The Rhizoma Anemarrhenae can also have most of gram positive bacterias and negative bacterium and suppresses or killing action, and the adding of Radix Trichosanthis, Folium Bambusae, Rhizoma Phragmitis has improved the effect of the Rhizoma Anemarrhenae and Gypsum Fibrosum; And can promote whole Chinese medicine composition to the greatest extent still not bring into play effect at the later stage waste heat, Radix Codonopsis, Radix Angelicae Sinensis and the Radix Astragali all have the effect of enhancing human body immunity power and resistance, the effect of moving that the prevention of highly pathogenic PRRS is played; Radix Angelicae Sinensis can also provide a large amount of vitamin and trace element to guarantee the symptom of organism metabolism; The Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication is good at clearing away lung-heat especially; Be the medicine of suiting the medicine to the illness of treatment highly pathogenic PRRS, the adding of Folium Sennae promotes the elimination that the intestines and stomach is stagnant.

Further preferred, saidly be used to prevent and treat the high Chinese medicine composition that causes a disease pig blue-ear disease only constitute by said components.

The said Chinese medicine composition that is used for preventing and treating highly pathogenic PRRS, the ratio of weight and number of various components can be preferably: the Rhizoma Anemarrhenae 40～60 weight portions, Gypsum Fibrosum 25～35 weight portions, Radix Trichosanthis 10～20 weight portions, Herba Lophatheri 10～20 weight portions, Rhizoma Phragmitis 10～20 weight portions, Flos Lonicerae 5～15 weight portions, Radix Scutellariae 15～25 weight portions, Radix Paeoniae Rubra 5～15 weight portions, Radix Stellariae 5～15 weight portions, Radix Angelicae Sinensis 15～25 weight portions, Folium Sennae 5～15 weight portions, Radix Codonopsis 15～25 weight portions and the Radix Astragali 15～25 weight portions.

The said Chinese medicine composition that is used for preventing and treating the animal highly pathogenic PRRS, the ratio of weight and number of various components also can further be preferably: the Rhizoma Anemarrhenae 50～60 weight portions, Gypsum Fibrosum 30～35 weight portions, Radix Trichosanthis 15～20 weight portions, Herba Lophatheri 15～20 weight portions, Rhizoma Phragmitis 15～20 weight portions, Flos Lonicerae 10～15 weight portions, Radix Scutellariae 20～25 weight portions, Radix Paeoniae Rubra 10～15 weight portions, Radix Stellariae 10～15 weight portions, Radix Angelicae Sinensis 20～25 weight portions, Folium Sennae 10～15 weight portions, Radix Codonopsis 20～25 weight portions and the Radix Astragali 20～25 weight portions.

The said Chinese medicine composition that is used for preventing and treats highly pathogenic PRRS can also comprise Semen Cuscutae.

Semen Cuscutae: sweet in the mouth, suffering, property is flat, goes into the liver,kidney,spleen warp, and the kidney invigorating and essence nourishing is arranged, and the effect of nourishing the liver to improve visual acuity is mainly used in the sexual impotence of insufficiency of kidney-YANG, seminal emission premature ejaculation, frequent micturition, dizziness and tinnitus; The pain in the lumbar region of suffering from a deficiency of the kidney, married woman's leukorrhagia, nausea is solid; Dim-sighted, the blurring of vision of the binocular of both liver and kidney deficiency, deficiency of liver-blood; The loose stool stomachache of asthenia of both the spleen and kidney, symptoms such as aqueous-grainy diarrhea through adding Semen Cuscutae, promote the reparation of liver and kidney cells; Nourishing kidney-yin, protecting liver and detoxication enhances metabolism; Slow down epidemic situation, strengthen resistance against diseases, the generation of reduce miscarriage simultaneously, producing stillborn fetus, weak tire or mummy tire.

The ratio of weight and number of said Semen Cuscutae in said Chinese medicine composition is that Semen Cuscutae 10～20 weight portions further are preferably 15～20 weight portions.

The said Chinese medicine composition that is used for preventing and treats highly pathogenic PRRS can also comprise Fructus Crataegi, Pericarpium Citri Reticulatae Viride and Fructus Oryzae Germinatus.

Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature is gone into spleen, stomach, Liver Channel, is used for promoting digestion and invigorating the stomach, and the circulation of qi promoting dissipating blood stasis mainly is used for treating accumulation of food in the stomach and intes tine due to indigestion, has loose bowels, dysentery, Fructus Crataegi is the staple of treatment dyspepsia, Fructus Crataegi can increase the secretion of peptic digestion enzyme, facilitating digestion; Dysentery bacterium, escherichia coli, bacillus pyocyaneus, staphylococcus aureus etc. had the obvious suppression effect.

Fructus Oryzae Germinatus: sweet in the mouth, property are put down, and go into spleen, stomach warp, are used for promoting digestion and removing stagnation, and spleen benefiting and stimulating the appetite is mainly treated eating accumulation, wrist abdomen feeling of fullness, and flesh is disliked food, insufficiency of the spleen few food.

Pericarpium Citri Reticulatae Viride: bitter in the mouth, suffering, warm in nature, go into liver, gallbladder, stomach warp; Have easypro gallbladder dispelling the stagnated QI, the stagnant effect of removing food stagnancyization, be used for stagnation of QI due to dyspepsia, abdominal distention; Infantile malnutrition, old man's abdominal distention of stopping eating has gentle stimulation to gastrointestinal tract; Can facilitating digestion liquid secretion and get rid of gas in the body, again can the diastole gastrointestinal smooth muscle, mainly show as the effect of adjustment gastrointestinal function.

Through adding these three kinds of auxiliary elements of Fructus Crataegi, Fructus Oryzae Germinatus and Pericarpium Citri Reticulatae Viride, can eliminate eating accumulation, facilitating digestion increases enterogastric peristalsis; In case distension and fullness in the abdomen, lack of appetite, dysentery has and regulates the flow of vital energy; Stomach function regulating, the effect of spleen invigorating makes pig feed desire to heighten, disease resistance enhancemen and immunologic function; Reduce disease incidence rate, play a role in health care, thus prevention and treatment highly pathogenic PRRS.

Said Fructus Crataegi, Pericarpium Citri Reticulatae Viride, the ratio of weight and number of Fructus Oryzae Germinatus in said Chinese medicine composition are Fructus Crataegi 3～5 weight portions, Pericarpium Citri Reticulatae Viride 3～5 weight portions and Fructus Oryzae Germinatus 3～5 weight portions.

The said Chinese medicine composition that is used for preventing and treats highly pathogenic PRRS can also comprise Radix Glycyrrhizae.

Radix Glycyrrhizae: sweet in the mouth, property is flat, goes into 12 warps, and heat-clearing and toxic substances removing is arranged, and is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating with in, relieving spasm to stop pain is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, and is weak; Can alleviate contracture property pain in the abdomen; Relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play the QI invigorating neutralization through adding Radix Glycyrrhizae; Be in harmonious proportion the effect of each component; Simultaneously Radix Glycyrrhizae can in metabolism in the endotoxin that produces, keep digesting and assimilating normally and excretory function of ill pig, can prevent that just the endotoxic savings of ill pig is poisoned and disappearing of later stage physical function exhausts death.

The ratio of weight and number of said Radix Glycyrrhizae in said Chinese medicine composition is Radix Glycyrrhizae 5～10 weight portions.

The said Chinese medicine composition that is used for preventing and treats highly pathogenic PRRS can also comprise Colla Corii Asini.

Colla Corii Asini: sweet in the mouth, property are flat, go into lung, liver, kidney channel, and tonifying blood and arresting bleeding is arranged, and nourshing Yin and drynsessmoistening prescription effect can be used for the shallow complexion of various asthenia symptom, especially blood deficiency, and thin and weak weak, the head is dizzy, palpitation and insomnia; Malnutritional anemia, thrombocytopenic purpura; Deficient property hemoptysis; The haematemesis hematuria is had blood in stool; The cough dry pharynx of lung-dryness syndrome due to deficiency of YIN, sputum mixed with blood; Symptoms such as the spasm of muscles and vessels of pathogenic heat lingering, deficiency of YIN blood consumption, stirring-up of pathogenic wind in the interior resulting from deficiency, tetany, Colla Corii Asini has the erythrocytic generation of promotion, increases blood calcium concentration, promotes the hemostatic effect, and helps to strengthen the immunologic function of animal.

The ratio of weight and number of said Colla Corii Asini in said Chinese medicine composition is Colla Corii Asini 5～10 weight portions.

The pharmacological action of Chinese medicine composition of the present invention stops cytometaplasia for directly killing antigen, removes the body obstacle, the enhancing body function; Steadily neuroendocrine disturbance recovers immunologic function, replys appetite fast; Stimulate body reinforced platoon exclusive-OR function, analgesic antiinflammatory does not rebound, and induces cause of disease, toxin, dead cell to compile and excrete to injection point; Come off voluntarily after inflammation is eliminated, venesection, the toxin expelling function of promoting blood circulation to disperse blood clots is arranged, have artificial lymphatic function.

The present invention also provides the above-mentioned method for preparing that is used to prevent and treat the Chinese medicine composition of highly pathogenic PRRS, and it comprises:

In the said first step, it is 85%～95% that adding alcoholic acid contains pure quality, and the reflux time is 2 hours～4 hours; The number of times that extracts is preferably 2～4 times; The alcoholic acid quality optimization that adds is 5～10 times of Rhizoma Anemarrhenae quality, and concentrating under reduced pressure reclaims ethanol, and the quality that reclaims when ethanol stops recovery when above for 75% of the initial alcoholic acid quality that adds; The extractum refrigerated storage temperature is preferably 0～3 ℃; When adopting spray dryer to carry out drying, EAT is preferably 150 ℃～170 ℃, and leaving air temp is preferably 50 ℃～60 ℃.

In said second step, decocting time is 1 hour～3 hours, and the quality optimization of the water of adding is 3～5 times of gypsum quality sum.

In said the 4th step, decocting time is 1 hour～3 hours, and the quality optimization of the water of adding is Radix Angelicae Sinensis, Radix Codonopsis and the Radix Astragali 3～5 times of quality separately.

Also further comprise in the said method for preparing, Semen Cuscutae is pulverized, decocte with water 1～3 time, decocting time is 1 hour～3 hours; The quality optimization of the water that adds is 3～5 times of Semen Cuscutae quality, merges decoction liquor, filters; Static spending the night extracted the upper strata stillness of night, and concentrating under reduced pressure removes and anhydrates; Be dried to dried cream, pulverize and sieve with pulverizer, obtaining granularity is 100～200 purpose powder.

Also further comprise in the said method for preparing, Radix Glycyrrhizae is put into marmite fry into charcoal, be ground into smalls with pulverizer, sieve, obtaining granularity is 100～200 purpose powder.

Also further comprise in the said method for preparing, Fructus Crataegi, Pericarpium Citri Reticulatae Viride and Fructus Oryzae Germinatus are mixed pulverize, decocte with water 1～3 time, decocting time is 1 hour～3 hours; The quality optimization of the water that adds is Fructus Crataegi, Pericarpium Citri Reticulatae Viride and Fructus Oryzae Germinatus quality sum 3～5 times, merges decoction liquor, filters; Static spending the night extracted the upper strata stillness of night, and concentrating under reduced pressure removes and anhydrates; Be dried to dried cream, pulverize and sieve with pulverizer, obtaining granularity is 100～200 purpose powder.

Comprise further also in the said method for preparing that with Colla Corii Asini decocte with water 1～3 time, decocting time is 1 hour～3 hours; The quality optimization of the water that adds is 3～5 times of Colla Corii Asini quality, merges decoction liquor, filters; Static spending the night extracted the upper strata stillness of night, and concentrating under reduced pressure removes and anhydrates; Be dried to dried cream, pulverize and sieve with pulverizer, obtaining granularity is 100～200 purpose powder.

Said Chinese medicine composition pharmaceutical dosage form can be decoction, powder, honey refining pill, hydration pill, tablet, capsule, oral liquid, granule, colloid or syrup.

The administering mode of said Chinese medicine composition is oral.

The present invention also provides the method for using of above-mentioned Chinese medicine composition, and it comprises: said Chinese medicine composition is put into water-soluble stirring and soaked decoction, irritate clothes subsequently and give the pig that suffers from highly pathogenic PRRS, continuous irrigation clothes 3 days～5 days.

The present invention also provides the another kind of method for using of above-mentioned Chinese medicine composition; It comprises: said Chinese medicine composition is mixed stirring mutually with feed vector; With the ill pig of this stirred mixture feeding, 5 days～7 days is a course of treatment subsequently, continuously 10 week～12 weeks of feeding.

The present invention also provides a kind of fodder compound, comprises above-mentioned Chinese medicine composition additive and feed vector in the said composition.

Said feed vector is preferably one or more in corn, Semen Tritici aestivi, Fructus Hordei Vulgaris, the bean cake.

The ratio of weight and number of said feed vector and said Chinese medicine composition additive can be 100 weight portions: 5～15 weight portions further are preferably 100 weight portions: 10～15 weight portions.

Can also comprise enzymatic compositions in the said fodder compound, with respect to the feed vector of 100 weight portions, the weight fraction of said enzymatic compositions is 3～5 weight portions.

Said enzymatic compositions comprises 1,4 beta-glucanase, 'beta '-mannase, cellulase, amylase and protease.

The ratio of weight and number of various enzymes is 1,4 beta-glucanase 30～45 weight portions in the said enzymatic compositions, 'beta '-mannase 10～15 weight portions, cellulase 3～6 weight portions, amylase 15～25 weight portions, protease 15～30 weight portions.

Can also add other additive such as ammonium sulfate, sodium bicarbonate and maltodextrin in the said fodder compound.

With respect to the feed vector of 100 weight portions, the ratio of weight and number of each additive component is that said ammonium sulfate is preferably 3～5 weight portions in the said fodder compound, and said sodium bicarbonate is preferably 1～3 weight portion, and said maltodextrin is preferably 3～5 weight portions.

The present invention also provides the method for preparing of above-mentioned fodder compound, and it comprises:

The first step prepares the said Chinese medicine composition as additive;

Second step; Pulverize with feed vector with prepared Chinese medicine composition additive, add entry and mix in said ratio; Whipping temp maintains 30～40 ℃, and mixing time is 40～60 minutes, wherein; With respect to the feed vector of 100 weight portions, the amount of the water that is added is preferably 35～50 weight portions;

The 3rd step, the material that obtains in second step is put into the steam manipulator carry out preparatory gelatinizing, in this step, the temperature in the steam manipulator is preferably 75 ℃～80 ℃, and at this moment, the starch burn degree of feedstuff is 60～70%;

The 4th step; The material of the 3rd preparatory gelatinizing of step is carried out steam and boils and push in extruder, in this step, said extruder can be single-screw extrusion machine or twin (double) screw extruder; Temperature in the extruder is preferably 105～115 ℃; Pressure is adjusted to 0.7MPa～1.6MPa, and at this moment, the starch burn degree of feedstuff is 95～98%;

The 5th step is with the said fodder compound of the dry acquisition of the material that obtains in the 4th step.

In the method for preparing of said fodder compound; Can also earlier said enzymatic compositions and said feed vector fully be mixed in said ratio in second step, add entry, under preferred 30～40 ℃ temperature, stir; After preferred 30～50 minutes; Add said Chinese medicine composition additive, remain on and continue under 30～40 ℃ the temperature to stir 20～40 minutes, further add ammonium sulfate, sodium bicarbonate and maltodextrin in said ratio subsequently and further stirred 10～20 minutes.

Below adopt embodiment to specify embodiment of the present invention, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can make much of and implement according to this.

The pathological change of highly pathogenic PRRS is: suffer from pig and typical icteroanemia occurs, cut open the visible mucosa of inspection, palor for eperythrozoonosis characteristic pathological change after death, blood is thin; The spleen enlargement, lymphadenectasis, ascites; Hydrothorax, hydropericardium.Histopathologic examination has: cerebrovascular endothelial cell swelling, and there is the serosity cellulose to ooze out, the brain mantle is congested, hemorrhage, a large amount of leukocyte recruitments.Neurocyte nuclear swelling, necrosis, fragmentation.Bone marrow proliferation.Liver has iron content blood flavochrome deposition, the lobules of liver partial necrosis, and hepatocyte cloudy swelling, vacuolar degeneration have petechial hemorrhage and necrosis region; The central vein expansion, edema, hepatic sinusoid expansion, interlobular bile duct expansion; Interstitial pneumonia, splenaemia, hemorrhage, the folliculus fibroplasia, folliculus disappears.

Embodiment 1 Chinese medicine composition of the present invention is to the acute toxicity test of mice

1. experimental animal

The healthy KM mice of SPF level, 30, male and female half and half, body weight 20-25g; Available from the Sichuan Provincial Academy of Traditional Chinese Medicine Experimental Animal Center

2. trial drug

The 60g Rhizoma Anemarrhenae is packed in the multi-function extractor (Shanghai along appearance scientific & technical corporation produce), and the alcohol heating reflux that adds 300g 90% extracts 2 times, and each 3 hours, merge extractive liquid; Centrifugal, filter, obtain filtrate; Concentrating under reduced pressure reclaims ethanol, when the ethanol quality that reclaims for the initial ethanol quality that adds 80% the time stop to reclaim, obtain extractum; Extractum 0 ℃ of stored refrigerated, is got into drying in the spray dryer (Changzhou section dragon drying machinery equipment company limited is produced) subsequently, and EAT is 160 ℃; Leaving air temp is 60 ℃, pulverizes and sieves with pulverizer, and obtaining granularity is 50～100 purpose Common Anemarrhena Rhizomes; The 35g Gypsum Fibrosum is pulverized, added the 105g decocting and boil 3 times, decocted 2 hours at every turn, merge decoction liquor, filter, static spending the night extracted the upper strata stillness of night, and concentrating under reduced pressure removes and anhydrates, and is dried to dried cream, pulverizes and sieves with pulverizer, and obtaining granularity is 100～150 purpose gypsum powders; 20g Radix Trichosanthis, 20g Herba Lophatheri, 20g Rhizoma Phragmitis, 15g Flos Lonicerae, 25g Radix Scutellariae, 15g Radix Paeoniae Rubra, 15g Radix Stellariae and 15g Folium Sennae are mixed, put into marmite and fry into charcoal, be ground into smalls with pulverizer, sieve, obtaining granularity is 100～200 purpose powder; 25g Radix Angelicae Sinensis, 25g Radix Codonopsis and the 25g Radix Astragali are added the 75g decocting respectively boil 3 times, each 2 hours, merge decoction liquor separately; Filter, static spending the night extracted the upper strata stillness of night; Concentrating under reduced pressure removes and anhydrates; Be dried to dried cream respectively, pulverize and sieve, obtain 70～120 purpose Chinese Angelica Roots, Radix Codonopsis powder and Radix Astragali powder; With being stirred to evenly under the normal temperature and pressure conditions in the above-mentioned powder input blender, obtain said Chinese medicine composition.

3. detectable

Serum AST, ALT detection kit are available from giving birth to company in Beijing

4. checkout equipment

Micro-200 semiautomatic biochemistry detector, analytical balance, dissecting instrument, syringe, test tube etc.

5. test method

After 3 days adaptabilities are raised, be divided into 5 groups (male and female half and half) at random, every group each 10; Matched group, 4 various dose groups (only be respectively 76mg/, 152.1mg/, 219.9mg/, 357.6mg/ only).Mice free choice feeding, drinking-water in the feeding process, change water every day, the next day change bedding and padding.The whole test phase is 7 days.

6. testing index and method

(1) clinicing symptom observation: every day the viewing test Mus the mental status, diet situation, record morbidity every day death condition.

(2) pathological observation: cut open inspection for dead Mus and observe the internal organs variation.

(3) growth indexes is observed: the test Mus is carried out routine weighing; Off-test, slaughter that Mus weighs in, the heavy organ index of internal organs measures: cut open the inspection kunming mice, dirty, the spleen of coring, liver, kidney, testis, ovary are weighed, according to the computes organ index: organ index=internal organs weight/body weight * 100.

(4) liver function changes observation: after the off-test, slaughter Mus, take blood separation serum, measure AST, ALT.

7. date processing: above The data SPSS11.0 carries out analytic statistics.

Clinicing symptom observation

Matched group and test group Mus, the mental status and diet are desired, respond is not seen significantly unusual to external world.Each organizes Mus morbidity and death condition such as following table 1.

Table 1

Divide into groups	Sum	Morbidity (only)	Dead (only)	Mortality rate (%)
					1 (76mg/ only)	10	0	0	0
2 (152.1mg/ only)	10	0	0	0
					3 (219.9mg/ only)	10	0	0	0
4 (357.6mg/ only)	10	0	0	0
					Matched group	10	0	0	0

Pathological observation: matched group and test group, cut open after Mus is slaughtered to examine to observe and do not see the tangible pathological change of observation internal organs.

Growth indexes is observed: off-test, slaughter that Mus weighs in, the internal organs weight analysis is seen table 2.

Table 2

Divide into groups	The liver index	Cardiac index	The kidney index	The lungs index	Index and spleen index
						1 (76mg/ only)	5.57 +0.11	0.73 +0.06	1.31 +0.09	0.67 +0.06	0.42 +0.03
2 (152.1mg/ only)	5.73 +0.29	0.72 +0.05	1.27 +0.11	0.69 +0.03	0.47 +0.06
						3 (219.9mg/ only)	5.61 +0.17	0.69 +0.11	1.36 +0.17	0.71 +0.06	0.49 +0.09
4 (357.6mg/ only)	5.92 +0.25	0.70 +0.02	1.35 +0.21	0.69 +0.11	0.50 +0.02
						Matched group	5.17 +0.16	0.75 +0.03	1.40 +0.11	0.67 +0.09	0.51 +0.09

Liver function changes to be observed

After the off-test, slaughter Mus, take blood separation serum, mensuration AST, ALT see table 3.The result shows and respectively organizes data and normal healthy controls group to compare difference not remarkable, all is in normal range.

Table 3

Divide into groups	Sum	ALT	AST
				1 (76mg/ only)	10	39.26 +3.61	129.19 +13.79
2 (152.1mg/ only)	10	37.15 +2.19	137.45 +21.03
				3 (219.9mg/ only)	10	38.56 +3.01	133.67 +19.21
4 (357.6mg/ only)	10	38.97 +1.59	135.27 +15.62
				Matched group	10	40.12 +5.33	136.29 +17.58

Embodiment 2 Chinese medicine compositions of the present invention are to the long term toxicity test of ill pig

Get 10 of adult ill pigs; Body weight is at 150～200kg; Long term toxicity test is carried out in the long-term administration of half and half, 12 week of male and female; The result shows that the equal no abnormality seen of indexs such as the general situation of all pigs, growth promoter, routine blood test, liver, renal function changes, and histopathology and gross necropsy are not also seen pathological change.

The preparation of embodiment 3 Chinese medicine compositions 1

The 600g Rhizoma Anemarrhenae is packed in the multi-function extractor (Shanghai along appearance scientific & technical corporation produce), and the alcohol heating reflux that adds 3000g 90% extracts 2 times, and each 3 hours, merge extractive liquid; Centrifugal, filter, obtain filtrate; Concentrating under reduced pressure reclaims ethanol, when the ethanol quality that reclaims for the initial ethanol quality that adds 80% the time stop to reclaim, obtain extractum; Extractum 0 ℃ of stored refrigerated, is got into drying in the spray dryer (Changzhou section dragon drying machinery equipment company limited is produced) subsequently, and EAT is 160 ℃; Leaving air temp is 60 ℃, pulverizes and sieves with pulverizer, and obtaining granularity is 50～100 purpose Common Anemarrhena Rhizomes; The 350g Gypsum Fibrosum is pulverized, added the 1050g decocting and boil 3 times, decocted 2 hours at every turn, merge decoction liquor; Filter, static spending the night extracted the upper strata stillness of night, and concentrating under reduced pressure removes and anhydrates; Be dried to dried cream, pulverize and sieve with pulverizer, obtaining granularity is 100～150 purpose gypsum powders; 200g Radix Trichosanthis, 200g Herba Lophatheri, 200g Rhizoma Phragmitis, 150g Flos Lonicerae, 250g Radix Scutellariae, 150g Radix Paeoniae Rubra, 150g Radix Stellariae and 150g Folium Sennae are mixed; Put into marmite and fry into charcoal; Be ground into smalls with pulverizer, sieve, obtaining granularity is 100～200 purpose powder; 250g Radix Angelicae Sinensis, 250g Radix Codonopsis and the 250g Radix Astragali are added the 750g decocting respectively boil 3 times, each 2 hours, merge decoction liquor separately; Filter, static spending the night extracted the upper strata stillness of night; Concentrating under reduced pressure removes and anhydrates; Be dried to dried cream respectively, pulverize and sieve, obtain 70～120 purpose Chinese Angelica Roots, Radix Codonopsis powder and Radix Astragali powder; The 200g Semen Cuscutae is pulverized, added the 150g decocting and boil 3 times, each decocting time is 1 hour, merges decoction liquor; Filter, static spending the night extracted the upper strata stillness of night, and concentrating under reduced pressure removes and anhydrates; Be dried to dried cream, pulverize and sieve with pulverizer, obtaining granularity is 100～200 purpose powder; The 100g Radix Glycyrrhizae is put into marmite fry into charcoal, be ground into smalls with pulverizer, sieve, obtaining granularity is 100～200 purpose powder; 50g Fructus Crataegi, 50g Pericarpium Citri Reticulatae Viride and 50g Fructus Oryzae Germinatus are mixed pulverizing, add the 450g decocting and boil 2 times, each decocting time is 3 hours, merges decoction liquor; Filter, static spending the night extracted the upper strata stillness of night, and concentrating under reduced pressure removes and anhydrates; Be dried to dried cream, pulverize and sieve with pulverizer, obtaining granularity is 100～200 purpose powder, the 100g Colla Corii Asini is added in the 300g water decoct 3 times; Each decocting time is 1 hour, merges decoction liquor, filters static spending the night; Extract the upper strata stillness of night, concentrating under reduced pressure removes and anhydrates, and is dried to dried cream, pulverizes and sieves with pulverizer; Obtaining granularity is 100～200 purpose powder, above-mentioned powder is dropped in the blender be stirred to evenly under the normal temperature and pressure conditions, obtains said Chinese medicine composition 1.

The preparation of embodiment 4 Chinese medicine compositions 2

The 500g Rhizoma Anemarrhenae is packed in the multi-function extractor (Shanghai along appearance scientific & technical corporation produce), and the alcohol heating reflux that adds 2500g 90% extracts 2 times, and each 3 hours, merge extractive liquid; Centrifugal, filter, obtain filtrate; Concentrating under reduced pressure reclaims ethanol, when the ethanol quality that reclaims for the initial ethanol quality that adds 80% the time stop to reclaim, obtain extractum; Extractum 0 ℃ of stored refrigerated, is got into drying in the spray dryer (Changzhou section dragon drying machinery equipment company limited is produced) subsequently, and EAT is 160 ℃; Leaving air temp is 60 ℃, pulverizes and sieves with pulverizer, and obtaining granularity is 50～100 purpose Common Anemarrhena Rhizomes; The 300g Gypsum Fibrosum is pulverized, added the 900g decocting and boil 3 times, decocted 2 hours at every turn, merge decoction liquor; Filter, static spending the night extracted the upper strata stillness of night, and concentrating under reduced pressure removes and anhydrates; Be dried to dried cream, pulverize and sieve with pulverizer, obtaining granularity is 100～150 purpose gypsum powders; 150g Radix Trichosanthis, 150g Herba Lophatheri, 150g Rhizoma Phragmitis, 100g Flos Lonicerae, 200g Radix Scutellariae, 100g Radix Paeoniae Rubra, 100g Radix Stellariae and 100g Folium Sennae are mixed; Put into marmite and fry into charcoal; Be ground into smalls with pulverizer, sieve, obtaining granularity is 100～200 purpose powder; 200g Radix Angelicae Sinensis, 200g Radix Codonopsis and the 200g Radix Astragali are added the 600g decocting respectively boil 3 times, each 2 hours, merge decoction liquor separately; Filter, static spending the night extracted the upper strata stillness of night; Concentrating under reduced pressure removes and anhydrates; Be dried to dried cream respectively, pulverize and sieve, obtain 70～120 purpose Chinese Angelica Roots, Radix Codonopsis powder and Radix Astragali powder; With being stirred to evenly under the normal temperature and pressure conditions in the above-mentioned powder input blender, obtain said Chinese medicine composition 2.

The preparation of embodiment 5 fodder compounds 1

Chinese medicine composition 1 additive of 10kg wheatfeed carrier and 1.5kg embodiment 3 preparations is pulverized, is added 3.5kg water and mixes; Whipping temp maintains 40 ℃; Mixing time is 60 minutes, and the material of acquisition is put into the steam manipulator and carried out preparatory gelatinizing, and the temperature in the steam manipulator is 80 ℃; At this moment, the starch burn degree of feedstuff is 65%; The material of gelatinizing is carried out steam boil and push in single-screw extrusion machine, the temperature in the extruder is 105 ℃, and pressure is adjusted to 1.6MPa, and at this moment, the starch burn degree of feedstuff is 98%; The said fodder compound 1 of the dry acquisition of the material that obtains.

The preparation of embodiment 6 fodder compounds 2

Chinese medicine composition 2 additives of 10kg wheatfeed carrier and 1kg embodiment 4 preparations are pulverized, are added 3.5kg water and mix; Whipping temp maintains 40 ℃; Mixing time is 60 minutes, and the material of acquisition is put into the steam manipulator and carried out preparatory gelatinizing, and the temperature in the steam manipulator is 80 ℃; At this moment, the starch burn degree of feedstuff is 65%; The material of gelatinizing is carried out steam boil and push in single-screw extrusion machine, the temperature in the extruder is 105 ℃, and pressure is adjusted to 1.6MPa, and at this moment, the starch burn degree of feedstuff is 98%; The said fodder compound 2 of the dry acquisition of the material that obtains.

Clinical experiment 1

With 360 health pig (male and female half and half; Body weight is between 150kg～200kg) be divided into three groups at random; Group I is the counteracting toxic substances matched group, and group II is the test group of taking the Chinese medicine composition 1 back counteracting toxic substances that embodiment 3 makes, and group III is the test group of taking the Chinese medicine composition 2 back counteracting toxic substances that embodiment 4 makes; Group I only feeds with the normal feedstuff Semen Tritici aestivi, and every day, Chinese medicine composition that every pig is joined was suitable with 1.5 gram raw material of Chinese medicine doses; Each organizes pig free choice feeding, drinking-water, Routine Management; Raise identical natural law, observe disease pig symptom when 9:00 and 16:00 every day, and dead pig is only weighed, the anatomic observation pathological change; And perform itemized record; Dead pig only weighed, dissects in ten days to having tested, and record pathological changes situation, after test is accomplished; Test mortality rate, effective percentage are carried out data statistics, and concrete outcome is seen table 4.

Table 4

Divide into groups	Sum	Ill number	Death toll	Mortality rate (%)	Effective percentage (%)
						Group I	120	120	98	81.7%	0
Group II	120	0	0	0	100%
						Group III	120	5	0	0	95.83%

In this experimentation, allly at duration of test the symptom of highly pathogenic PRRS and dead appears, the ill apparition person of necropsy, be judged to infect dead.

Effectively after medication, not ill pig only is effectively, and the percentage rate that every group of health pig number accounts for the test pig number is an effective percentage.From table 4, we can find out, adopt Chinese medicine composition of the present invention that highly pathogenic PRRS is had significant preventive effect.

Clinical experiment 2

With 480 health pig (male and female half and half; Body weight is between 150kg～200kg) be divided into four groups at random, group I is the normal healthy controls group, group II is the counteracting toxic substances matched group; Group III is the test group of taking the Chinese medicine composition 1 that embodiment 3 makes; The group IV is the test group of taking the Chinese medicine composition 2 that embodiment 4 makes, and group I only feeds with the normal feedstuff Semen Tritici aestivi, and group II uses the normal feedstuff Semen Tritici aestivi nursing identical with the normal healthy controls group; Not administration behind the counteracting toxic substances; Group III uses the normal feedstuff Semen Tritici aestivi identical with the normal healthy controls group to feed with the group IV, and after counteracting toxic substances the highly pathogenic PRRS typical clinical symptom occurred in 48 hours, sneaks into Chinese medicine composition 1 and Chinese medicine composition 2 that embodiment 3 and embodiment 4 make in the drinking-water in test group, and every day, Chinese medicine composition that every pig is joined was with 1.5 to restrain the raw material of Chinese medicine doses suitable; Each organizes pig free choice feeding, drinking-water, Routine Management; Raise identical natural law, observe disease pig symptom when 9:00 and 16:00 every day, and dead pig is only weighed, the anatomic observation pathological change; And perform itemized record; Dead pig only weighed, dissects in ten days to having tested, and record pathological changes situation, after test is accomplished; Test mortality rate, cure rate, effective percentage are carried out data statistics, and concrete outcome is seen table 5.

Table 5

?	Sick pig number	Death toll	Cure number	Significant figure	Mortality rate %	Cure rate %	Effective percentage %
								Group I	0	0	-	-	0	-	-
Group II	120	98	-	-	81.7%	-	-
								Group III	120	10	102	110	8.33%	85.0%	91.7%
The group IV	120	4	113	116	3.33%	94.2%	96.7%

Effectively after medication, dead pig only be effectively, the percentage rate that every group of survival pig number accounts for the test pig number be the effective percentage recovery from illness after medication, it is normal that the mental status, appetite etc. are recovered, and all belongs to recovery from illness, the percentage rate that the pig number of fully recovering accounts for the test pig number is a cure rate.

From table 5, we can find out, adopt Chinese medicine composition of the present invention that highly pathogenic PRRS is had significant curative effect.

For example: in JIUYUE, 2010, the Sishui County Liu Jia of Handan City, Hebei province raises in the village main Liu and cultures 180 growing and fattening pigs, and all morbidities are suffered from temperature of pig body and raise and reach 40 ℃～42 ℃, and be and delay pattern of fever, anorexia, bradykinesia is reluctant activity.Visible subsequently nasal secretion increases, cough, and dyspnea, visual mucosa is pale, jaundice.The feces initial stage is stiff and have mucus and mucosa, and constipation alternately takes place with diarrhoea.Auricle, afterbody and limb end skin cyanosis are kermesinus or aubergine.Clinical diagnosis is a highly pathogenic PRRS, ill pig fed by 1.5g/kg body weight dosage batch mixing, and 7 days one courses of treatment, 10 courses of treatment of logotype, final dead 5, cures 175, cure rate is 92.2%, follows up a case by regular visits to so far to recur.

This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any professional and technical personnel of being familiar with possibly utilize the technology contents of above-mentioned announcement to change or be modified as the equivalent embodiment of equivalent variations.But everyly do not break away from technical scheme content of the present invention, to any simple modification, equivalent variations and remodeling that above embodiment did, still belong to the protection domain of technical scheme of the present invention according to technical spirit of the present invention.

Claims

1. a Chinese medicine composition that is used to prevent and treat highly pathogenic PRRS is characterized in that, comprising: the Rhizoma Anemarrhenae, Gypsum Fibrosum, Radix Trichosanthis, Herba Lophatheri, Rhizoma Phragmitis, Flos Lonicerae, Radix Scutellariae, Radix Paeoniae Rubra, Radix Stellariae, Radix Angelicae Sinensis, Folium Sennae, Radix Codonopsis and the Radix Astragali.

2. Chinese medicine composition as claimed in claim 1; It is characterized in that: the ratio of weight and number of each component in the said Chinese medicine composition is the said Rhizoma Anemarrhenae 50～60 weight portions, said Gypsum Fibrosum 30～35 weight portions, said Radix Trichosanthis 15～20 weight portions, said Herba Lophatheri 15～20 weight portions, said Rhizoma Phragmitis 15～20 weight portions, said Flos Lonicerae 10～15 weight portions, said Radix Scutellariae 20～25 weight portions, said Radix Paeoniae Rubra 10～15 weight portions, said Radix Stellariae 10～15 weight portions, said Radix Angelicae Sinensis 20～25 weight portions, said Folium Sennae 10～15 weight portions, said Radix Codonopsis 20～25 weight portions and the said Radix Astragali 20～25 weight portions.

3. according to claim 1 or claim 2 Chinese medicine composition; It is characterized in that: the said Chinese medicine composition that is used for preventing and treats highly pathogenic PRRS can also comprise Semen Cuscutae; The ratio of weight and number of said Semen Cuscutae in said Chinese medicine composition is Semen Cuscutae 10～20 weight portions.

4. like the described Chinese medicine composition of claim 1 to 3; It is characterized in that: the said Chinese medicine composition that is used for preventing and treats highly pathogenic PRRS can also comprise Fructus Crataegi, Pericarpium Citri Reticulatae Viride and Fructus Oryzae Germinatus; Said Fructus Crataegi, Pericarpium Citri Reticulatae Viride, the ratio of weight and number of Fructus Oryzae Germinatus in said Chinese medicine composition are Fructus Crataegi 3～5 weight portions, Pericarpium Citri Reticulatae Viride 3～5 weight portions and Fructus Oryzae Germinatus 3～5 weight portions.

5. like the described Chinese medicine composition of claim 1 to 4; It is characterized in that: the said Chinese medicine composition that is used for preventing and treats highly pathogenic PRRS can also comprise Radix Glycyrrhizae; The ratio of weight and number of said Radix Glycyrrhizae in said Chinese medicine composition is Radix Glycyrrhizae 5～10 weight portions.

6. like the described Chinese medicine composition of claim 1 to 5; It is characterized in that: the said Chinese medicine composition that is used for preventing and treats highly pathogenic PRRS can also comprise Colla Corii Asini; The ratio of weight and number of said Colla Corii Asini in said Chinese medicine composition is Colla Corii Asini 5～10 weight portions.

7. a Chinese medicine composition that is used to prevent and treat the animal highly pathogenic PRRS is characterized in that, said Chinese medicine composition is prepared from through following method:

8. the method for preparing of each described Chinese medicine composition of claim 1 to 6 is characterized in that, comprising:

9. a fodder compound is characterized in that, comprising: as claim 1 to 7 each described Chinese medicine composition and feed vector of additive.

10. each described Chinese medicine composition of said claim 1 to 6 is used for preventing and treating the application of the medicine of highly pathogenic PRRS in preparation.