CN102228636A - Traditional Chinese medicine compositions for treating highly pathogenic reproductive and respiratory syndrome (PRRS) - Google Patents
Traditional Chinese medicine compositions for treating highly pathogenic reproductive and respiratory syndrome (PRRS) Download PDFInfo
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Abstract
Belonging to the field of traditional Chinese veterinary medicine, the invention discloses two traditional Chinese medicine compositions for treating highly pathogenic reproductive and respiratory syndrome. Wherein, one composition is mainly composed of crushed scutellaria, crushed andrographis paniculata, crushed dandelion, crushed Radix Astragali, crushed bushy sophora, crushed Herba Lopatheri, crushed herba fibraureae recisae, crushed honeysuckle, crushed forsythia and crushed licorice, and can be prepared into powder or premix. The other composition mainly consists of scutellaria extract, andrographis paniculata extract, dandelion extract, Radix Astragali extract, bushy sophora extract, Herba Lopatheri extract, herba fibraureae recisae extract, honeysuckle extract, forsythia extract and licorice extract, and can be prepared into injection, powder, aqueous agent, particulate agent or premix. The compositions of the invention have scientifically and reasonably proportioned materials, and the effective components can present increased curative effect through synergy. Thus, symptoms caused by highly pathogenic reproductive and respiratory syndrome can be alleviated and treated in different links. Able to address both the symptoms and root causes, the traditional Chinese medicine compositions of the invention have high cure rate, obvious curative effect, abundant medicine source, simple process, low cost, no medicine residue, and little toxic and side effect.
Description
Technical field
The invention belongs to field of traditional Chinese veterinary, relate to a kind of Chinese medicine composition for the treatment of high-pathogenicity blue ear disease.
Background technology
The breeding with breathing syndrome (PRRS) be by PRRS virus cause a kind of be the infectious disease of principal character with breeding difficulty and respiratory symptom, be commonly called as " reproductive and respiratory syndrome ".Since China's outburst, this disease took place in national each province in succession from highly pathogenic PRRS in 2006.It is anxious that this disease has morbidity, and propagation is rapidly, and is popular extensive, the sickness rate height, and dead back is the septicemia variation more; But with in-pig and 1 monthly age with the easy infection of interior piglet, the farrowing sow later stage miscarriage occurs, produces stillborn fetus, weak son and mummy tire; Characteristics such as control is difficult, and economic loss is big.The sickness rate of reproductive and respiratory syndrome in breeding pig and sow is more than 50%, and case fatality rate is up to 50～90%, and the piglet sickness rate can reach 100%, and mortality rate can reach more than 50%, and the sow abortion ratio can reach more than 30%, and the development of pig industry in serious threat.
Should disease mainly take vaccine to prevent at present, though obtained certain effect, but still have deficiency, control appears and phenomenon without cease.Because serotype that should disease is more, vaccine is limited by specificity, immuning failure often occurs.So it is very necessary to explore stable, the good method of preventing and treating of a kind of prevention effect.
Summary of the invention
In order to solve the deficiencies in the prior art, the invention provides that a kind of proportioning of selecting materials is scientific and reasonable, effect stability is reliable, the Chinese medicine composition of the treatment high-pathogenicity blue ear disease of instant effect, and its preparation method is provided.
To achieve these goals, the technical solution adopted in the present invention is as follows:
The invention provides a kind of Chinese medicine composition for the treatment of high-pathogenicity blue ear disease, it is characterized in that said composition is made up of the component of following parts by weight: 1～10 part Radix Scutellariae powder minces, 1～10 part Herba Andrographis ground product, 1～10 part Herba Taraxaci ground product, 1～10 part astragalus membranaceus powder mince, 1～10 part Rhizoma Phragmitis ground product, 1～10 part Herba Lophatheri ground product, 1～10 part Caulis Fibraureae ground product, 1～10 part Flos Lonicerae powder mince, 1～10 part Fructus Forsythiae powder minces and 1～10 part Radix Glycyrrhizae powder minces.
Described a kind of Chinese medicine composition for the treatment of high-pathogenicity blue ear disease, it is characterized in that also comprising that parts by weight are that 1～4 part Ramulus Et Folium Picrasmae ground product, Flos Carthami powder that parts by weight are 1～3 part mince, parts by weight are 1～2 part Cortex Lycii ground product, parts by weight are 1～2 part Radix Sophorae Tonkinensis ground product, gypsum powder that parts by weight are 1～3 part minces and parts by weight are one or more combination in 1～2 part the compound probiotic mycopowder.
The Chinese medicine composition of described treatment high-pathogenicity blue ear disease, it is characterized in that described compound probiotic mycopowder is that in Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus bulgaricus, lactobacillus casei, lactobacillus lactis, enterococcus faecalis, enterococcus faecalis, pediococcus acidilactici, lactoenterococcus, bacillus acidophilus and the Lactobacillus buchneri one or more combine.
The Chinese medicine composition of described treatment high-pathogenicity blue ear disease is characterized in that this pharmaceutical composition adds acceptable accessories and makes clinically or pharmaceutically acceptable dosage form, and described dosage form is powder or pre-mixing agent.
The present invention also provides the Chinese medicine composition of another kind of treatment high-pathogenicity blue ear disease, it is characterized in that said composition is made up of the component of following parts by weight: 1～10 part Radix Scutellariae extract, 1～10 part Herba Andrographis extract, 1～10 part Herba Taraxaci extract, 1～10 part Radix Astragali extract, 1～10 part Rhizoma Phragmitis extract, 1～10 part Herba Lophatheri extract, 1～10 part Caulis Fibraureae extract, 1～10 part Flos Lonicerae extract, 1～10 part Fructus Forsythiae extract and 1～10 part Radix Glycyrrhizae extract.
The Chinese medicine composition of described another kind of treatment high-pathogenicity blue ear disease, it is characterized in that, also comprise one or more the combination in the Radix Sophorae Tonkinensis extract that parts by weight are 1～4 part Ramulus et Folium Picrasmae, Flos Carthami extract that parts by weight are 1～3 part, parts by weight are 1～2 part Cortex Lycii extract and parts by weight are 1～2 part.
Extract in the Chinese medicine composition of another kind of treatment high-pathogenicity blue ear disease of the present invention, according to its effective separately constitutive property, through extract, concentrate, refining, drying forms, in order to reduce loss of active ingredients in the dry run, dry spray drying or the vacuum drying of adopting.The preparation method of the Chinese medicine composition of another kind of treatment high-pathogenicity blue ear disease of the present invention can be that every kind of medical material extracts separately, also can be to extract simultaneously after several medical materials are mixed in proportion, be preferably independent extraction after, press the extract mixed.
The Chinese medicine composition of another kind of treatment high-pathogenicity blue ear disease of the present invention is characterized in that this pharmaceutical composition adds acceptable accessories and makes clinically or pharmaceutically acceptable dosage form.Wherein, clinically or the preferred injection of pharmaceutically acceptable dosage form, powder, water preparation, pre-mixing agent or granule.
The invention provides Chinese medicine composition of treatment high-pathogenicity blue ear disease and preparation method thereof, have following advantage:
1, the Chinese medicine composition of treatment high-pathogenicity blue ear disease provided by the invention, clinical symptoms at reproductive and respiratory syndrome, adopted the Chinese herbal medicine of a large amount of heat-clearing and toxic substances removing, human body immunity improving power to make, but the proportioning of selecting materials is scientific and reasonable, the effective ingredient Synergistic of various medicines, after body absorbs, will be from various diseases or the complication that different links is alleviated and treatment is caused by reproductive and respiratory syndrome, instant effect, evident in efficacy, the cure rate height is to such an extent as to reach real treating both the principal and secondary aspects of a disease;
2, compositions of the present invention, the medicine source is abundant, and manufacture method is simple, and cost is low, adapts to the industrial needs of scale; And easy to use, drug residue free, without any side effects, satisfy greatly to the animal products requirement of safe production, market scope is wide.
3, the indication of compositions of the present invention also comprises foot and mouth disease, asthma, influenza, pig lung plague, contagious pleuropneumonia, circovirus disease.
4, compositions of the present invention also can be used as feed additive, to reach the purpose of prevention by reducing using dosage.
By following examples the present invention will be described more specifically, and it should be understood that described embodiment only is for the present invention is described, rather than limit the scope of the invention by any way.
The specific embodiment
5 one kinds of preparations for the treatment of the Chinese medicine composition composition powders of high-pathogenicity blue ear disease of embodiment 1～embodiment
Table 1 is a kind of concrete prescription for the treatment of the Chinese medicine composition of high-pathogenicity blue ear disease of embodiment 1～embodiment 5.
5 concrete prescriptions of table 1 embodiment of the invention 1～embodiment 5
A1 preparation method among the embodiment 1:
(1) Radix Scutellariae, Herba Andrographis, Herba Taraxaci, the Radix Astragali, Rhizoma Phragmitis, Herba Lophatheri, Caulis Fibraureae, Flos Lonicerae, Fructus Forsythiae and the Radix Glycyrrhizae after will cleaning respectively is at 40～50 ℃ of oven dry 5h down;
(2) Radix Scutellariae, Herba Andrographis, Herba Taraxaci, the Radix Astragali, Rhizoma Phragmitis, Herba Lophatheri, Caulis Fibraureae, Flos Lonicerae, Fructus Forsythiae and the Radix Glycyrrhizae pulverize separately after will drying, cross 200 mesh sieves then, respectively Radix Scutellariae powder mince, Herba Andrographis ground product, Herba Taraxaci ground product, astragalus membranaceus powder mince, Rhizoma Phragmitis ground product, Herba Lophatheri ground product, Caulis Fibraureae ground product, Flos Lonicerae powder mince, Fructus Forsythiae powder minces and Radix Glycyrrhizae powder minces;
(3) with parts by weight be that 10 parts Radix Scutellariae powder minces, parts by weight are 5 parts Herba Andrographis ground product, Herba Taraxaci ground product that parts by weight are 3 parts, astragalus membranaceus powder that parts by weight are 5 parts mince, parts by weight are 2 parts Rhizoma Phragmitis ground product, Herba Lophatheri ground product that parts by weight are 2 parts, Caulis Fibraureae ground product that parts by weight are 3 parts, Flos Lonicerae powder that parts by weight are 3 parts mince, parts by weight are that 2 parts Fructus Forsythiae powder minces and parts by weight are that 5 parts Radix Glycyrrhizae powder minces to mix and stirs 15min, the coefficient of variation that makes its uniformity gets final product less than 5%.
A2 preparation method among the embodiment 2:
(1) Radix Scutellariae, Herba Andrographis, Herba Taraxaci, the Radix Astragali, Rhizoma Phragmitis, Herba Lophatheri, Caulis Fibraureae, Flos Lonicerae, Fructus Forsythiae, Ramulus Et Folium Picrasmae and the Radix Glycyrrhizae after will cleaning respectively is at 40～50 ℃ of oven dry 5h down;
(2) Radix Scutellariae, Herba Andrographis, Herba Taraxaci, the Radix Astragali, Rhizoma Phragmitis, Herba Lophatheri, Caulis Fibraureae, Flos Lonicerae, Fructus Forsythiae, Ramulus Et Folium Picrasmae and the Radix Glycyrrhizae pulverize separately after will drying, cross 300 mesh sieves then, respectively Radix Scutellariae powder mince, Herba Andrographis ground product, Herba Taraxaci ground product, astragalus membranaceus powder mince, Rhizoma Phragmitis ground product, Herba Lophatheri ground product, Caulis Fibraureae ground product, Flos Lonicerae powder mince, Fructus Forsythiae powder minces, Ramulus Et Folium Picrasmae ground product and Radix Glycyrrhizae powder mince;
(3) be that 3 parts Radix Scutellariae powder minces with parts by weight, parts by weight are 6 parts Herba Andrographis ground product, parts by weight are 2 parts Herba Taraxaci ground product, parts by weight are that 8 parts astragalus membranaceus powder minces, parts by weight are 3 parts Rhizoma Phragmitis ground product, parts by weight are 1 part Herba Lophatheri ground product, parts by weight are 2 parts Caulis Fibraureae ground product, parts by weight are that 2 parts Flos Lonicerae powder minces, parts by weight are that 1 part Fructus Forsythiae powder minces, parts by weight are that Radix Glycyrrhizae powder that 1 part Ramulus Et Folium Picrasmae ground product and parts by weight are 3 parts minces to mix and stirs 12min, the coefficient of variation that makes its uniformity gets final product less than 5%.
A3 preparation method among the embodiment 3:
(1) Radix Scutellariae, Herba Andrographis, Herba Taraxaci, the Radix Astragali, Rhizoma Phragmitis, Herba Lophatheri, Caulis Fibraureae, Flos Lonicerae, Fructus Forsythiae and the Radix Glycyrrhizae after will cleaning respectively is at 40～50 ℃ of oven dry 5h down;
(2) Radix Scutellariae, Herba Andrographis, Herba Taraxaci, the Radix Astragali, Rhizoma Phragmitis, Herba Lophatheri, Caulis Fibraureae, Flos Lonicerae, Fructus Forsythiae and the Radix Glycyrrhizae pulverize separately after will drying, cross 250 mesh sieves then, respectively Radix Scutellariae powder mince, Herba Andrographis ground product, Herba Taraxaci ground product, astragalus membranaceus powder mince, Rhizoma Phragmitis ground product, Herba Lophatheri ground product, Caulis Fibraureae ground product, Flos Lonicerae powder mince, Fructus Forsythiae powder minces and Radix Glycyrrhizae powder minces; Gypsum powder is broken to 250 orders, obtains gypsum powder and mince;
(3) with parts by weight be that 6 parts Radix Scutellariae powder minces, parts by weight are 3 parts Herba Andrographis ground product, Herba Taraxaci ground product that parts by weight are 2 parts, astragalus membranaceus powder that parts by weight are 5 parts mince, parts by weight are 4 parts Rhizoma Phragmitis ground product, Herba Lophatheri ground product that parts by weight are 1 part, Caulis Fibraureae ground product that parts by weight are 3 parts, Flos Lonicerae powder that parts by weight are 5 parts mince, parts by weight are that 6 parts Fructus Forsythiae powder minces and parts by weight are that 2 parts Radix Glycyrrhizae powder minces to mix and stirs 18min, the coefficient of variation that makes its uniformity gets final product less than 5%.
A4 preparation method among the embodiment 4:
(1) Radix Scutellariae, Herba Andrographis, Herba Taraxaci, the Radix Astragali, Rhizoma Phragmitis, Herba Lophatheri, Caulis Fibraureae, Flos Lonicerae, Fructus Forsythiae and the Radix Glycyrrhizae after will cleaning respectively is at 40～50 ℃ of oven dry 4h down;
(2) Radix Scutellariae, Herba Andrographis, Herba Taraxaci, the Radix Astragali, Rhizoma Phragmitis, Herba Lophatheri, Caulis Fibraureae, Flos Lonicerae, Fructus Forsythiae and the Radix Glycyrrhizae pulverize separately after will drying, cross 280 mesh sieves then, respectively Radix Scutellariae powder mince, Herba Andrographis ground product, Herba Taraxaci ground product, astragalus membranaceus powder mince, Rhizoma Phragmitis ground product, Herba Lophatheri ground product, Caulis Fibraureae ground product, Flos Lonicerae powder mince, Fructus Forsythiae powder minces and Radix Glycyrrhizae powder minces; Lactobacillus casei is crushed to 280 orders, obtains the lactobacillus casei mycopowder;
(3) be that 3 parts Radix Scutellariae powder minces with parts by weight, parts by weight are 3 parts Herba Andrographis ground product, parts by weight are 3 parts Herba Taraxaci ground product, parts by weight are that 3 parts astragalus membranaceus powder minces, parts by weight are 3 parts Rhizoma Phragmitis ground product, parts by weight are 1 part Herba Lophatheri ground product, parts by weight are 5 parts Caulis Fibraureae ground product, parts by weight are that 3 parts Flos Lonicerae powder minces, parts by weight are that 3 parts Fructus Forsythiae powder minces, lactobacillus casei mycopowder that parts by weight are 1 part and parts by weight are that 2 parts Radix Glycyrrhizae powder minces and mix to stir 18min, the coefficient of variation that makes its uniformity gets final product less than 5%.
A5 preparation method among the embodiment 5:
(1) Radix Scutellariae, Herba Andrographis, Herba Taraxaci, the Radix Astragali, Rhizoma Phragmitis, Herba Lophatheri, Caulis Fibraureae, Flos Lonicerae, Fructus Forsythiae, Radix Glycyrrhizae, Flos Carthami and the Radix Sophorae Tonkinensis after will cleaning respectively is at 40～50 ℃ of oven dry 5h down;
Step 2, Radix Scutellariae, Herba Andrographis, Herba Taraxaci, the Radix Astragali, Rhizoma Phragmitis, Herba Lophatheri, Caulis Fibraureae, Flos Lonicerae, Fructus Forsythiae, Radix Glycyrrhizae, Flos Carthami and Radix Sophorae Tonkinensis pulverize separately after will drying, cross 220 mesh sieves then, respectively Radix Scutellariae powder mince, Herba Andrographis ground product, Herba Taraxaci ground product, astragalus membranaceus powder mince, Rhizoma Phragmitis ground product, Herba Lophatheri ground product, Caulis Fibraureae ground product, Flos Lonicerae powder mince, Fructus Forsythiae powder minces, Radix Glycyrrhizae powder minces, Flos Carthami powder minces and the Radix Sophorae Tonkinensis ground product; Gypsum powder is broken to 220 orders, obtains gypsum powder and mince; With Lactobacillus plantarum, enterococcus faecalis, lactobacillus lactis pulverize separately to 220 order, obtain Lactobacillus plantarum mycopowder, enterococcus faecalis mycopowder and lactobacillus lactis mycopowder respectively, with parts by weight is that lactobacillus lactis mycopowder that 3 parts Lactobacillus plantarum mycopowder, enterococcus faecalis mycopowder that parts by weight are 2 parts and parts by weight are 5 parts mixes and stirs 15min, obtains the compound probiotic mycopowder;
Step 3, with parts by weight is that 6 parts Radix Scutellariae powder minces, parts by weight are 3 parts Herba Andrographis ground product, parts by weight are 5 parts Herba Taraxaci ground product, parts by weight are that 2 parts astragalus membranaceus powder minces, parts by weight are 3 parts Rhizoma Phragmitis ground product, parts by weight are 8 parts Herba Lophatheri ground product, parts by weight are 4 parts Caulis Fibraureae ground product, parts by weight are that 1 part Flos Lonicerae powder minces, parts by weight are that 4 parts Fructus Forsythiae powder minces, parts by weight are that 5 parts Radix Glycyrrhizae powder minces, parts by weight are that 1 part Flos Carthami powder minces, parts by weight are 2 parts Radix Sophorae Tonkinensis ground product, parts by weight are that 1 part gypsum powder minces and parts by weight are that 2 parts compound probiotic mycopowder mix to stir 20min, the coefficient of variation that makes its uniformity gets final product less than 5%.
Above-mentioned powder adds 1～4% in feedstuff can effectively treat high-pathogenicity blue ear disease.
6 one kinds of preparations for the treatment of the Chinese medicine composition pre-mixing agent of high-pathogenicity blue ear disease of embodiment
Raw material is formed: A1～A5 number prescription among embodiment 1～embodiment 5
Preparation method: (1) crosses 100 mesh sieves with maize cob meal, and is standby;
(2) take by weighing medicine by above-mentioned prescription, make the gross weight of medicine reach 200g, mix homogeneously adds maize cob meal again to 500g, and mix homogeneously gets final product.
High-pathogenicity blue ear disease can be effectively treated in the interpolation 2.5～10% of this pre-mixing agent in feedstuff.
A kind of application for the treatment of the Chinese medicine composition of high-pathogenicity blue ear disease as feed additive.
Do not take place animal under the situation of reproductive and respiratory syndrome, the use amount of the Chinese medicine composition of above-mentioned treatment high-pathogenicity blue ear disease can be reduced to 1/10～1/5 of powder consumption and add feedstuff and be used as feed additive and use, can play preventive effect.
The preparation of the Chinese medicine composition composition powders of embodiment 7 another kind of treatment high-pathogenicity blue ear diseases
The prescription of the Chinese medicine composition of the another kind of treatment of the present invention high-pathogenicity blue ear disease sees Table 2.
The concrete prescription of the Chinese medicine composition of the another kind of treatment of table 2 high-pathogenicity blue ear disease
The preparation method of the Chinese medicine composition composition powders of another kind of treatment high-pathogenicity blue ear disease:
Above-mentioned B1～B5 number prescription taken by weighing each medicine, cross 100 mesh sieves behind the mix homogeneously, get final product.
This powder adds 0.1～0.5% in feedstuff can effectively treat high-pathogenicity blue ear disease.
The preparation of the Chinese medicine composition composition injection of embodiment 8 another kind of treatment high-pathogenicity blue ear diseases
Raw material is formed: B1～B5 number prescription among the embodiment 7.
Preparation method:
(1) take by weighing each medicine by above-mentioned formula ratio, the gross weight that makes medicine is 100g;
(2) add an amount of injection water stirring and make it become suspension, the NaOH solution that adds 5mol/L under condition of stirring dissolves medicine fully, regulates pH to 7.4;
(3) in above-mentioned solution, add the 10ml tween 80, add water for injection, stir the needle-use activated carbon of back adding 0.1%, heated and boiled 30min to 1000ml;
(4) filter, pH to 7.4 is transferred in filtrate cooling back, and after-teeming is penetrated water to 1000ml; Again behind the filtering with microporous membrane of 0.45 μ m, embedding in the ampere bottle, every 10ml, 105 ℃ of sterilization 25min, promptly.
Usage and consumption: intramuscular injection, per kilogram of body weight 0.05ml, every day 1～2 time, logotype 3 days.
The preparation method of the Chinese medicine composition water preparation of embodiment 9 another kind of treatment high-pathogenicity blue ear diseases
Raw material is formed: B1～B5 number prescription among the embodiment 7.
Preparation method:
(1) take by weighing each medicine by formula ratio, the gross weight that makes medicine is 100g;
(2) add suitable quantity of water and stir evenly, the NaOH solution that adds an amount of 5mol/L again dissolves medicine fully, and regulates its pH to 7.0.
(3) take by weighing the 3g sodium benzoate, add the suitable quantity of water stirring and make it dissolving fully;
The sodium benzoate solution that (4) will dissolve is poured drug solution into, adds the 8ml tween 80, mends and adds water to 1000ml, after stirring, leaves standstill 48h under the room temperature, centrifugal after, supernatant behind the filtering with microporous membrane of 0.45 μ m, packing, sterilization, promptly.
Usage and consumption: mix drink, every 1L water 0.5～2.5ml, 5 days one courses of treatment.
The preparation of the Chinese medicinal composition granules of embodiment 10 another kind of treatment high-pathogenicity blue ear diseases
Raw material is formed: B1～B5 number prescription among the embodiment 7.
Preparation method: take by weighing each extract by formula ratio, mixing is also crossed 100 mesh sieves; Add an amount of dextrin and starch, the ethanol of adding 60% is crossed 20 mesh sieves and is granulated as wetting agent; Wet granular drying, granulate detect, packing, promptly.
Usage and consumption: water-soluble drink-service, every 1L water 0.25～5g, 5 days one courses of treatment.
The preparation of the Chinese medicine composition pre-mixing agent of embodiment 11 another kind of treatment high-pathogenicity blue ear diseases
Raw material is formed: B1～B5 number prescription among the embodiment 7.
Preparation method:
(1), powdered rice hulls and wheatfeed are pressed 1: 1 mixing for standby use with rice husk, wheat bran pulverize separately to 100 order;
(2) take by weighing each medicine by B1～B5 number prescription among the embodiment 7, making the medicine gross weight is 200g, mix homogeneously, and reuse adds the mixture of powdered rice hulls and wheat bran, adds to 500g, and mix homogeneously gets final product.
This pre-mixing agent adds 0.25～1.25% in feedstuff can effectively treat high-pathogenicity blue ear disease.
The Chinese medicine composition of another kind of treatment high-pathogenicity blue ear disease is as the application of feed additive.Wherein, the Chinese medicine composition of treatment high-pathogenicity blue ear disease can comprise that parts by weight are 1～10 part Radix Scutellariae extract, parts by weight are 1～10 part Herba Andrographis extract, parts by weight are 1～10 part Herba Taraxaci extract, parts by weight are 1～10 part Radix Astragali extract, parts by weight are 1～10 part Rhizoma Phragmitis extract, parts by weight are 1～10 part Herba Lophatheri extract, parts by weight are 1～10 part Caulis Fibraureae extract, parts by weight are 1～10 part Flos Lonicerae extract, parts by weight are the Radix Glycyrrhizae extract that 1～10 part Fructus Forsythiae extract and parts by weight are 1～10 part; Can also comprise that parts by weight are 1～10 part Radix Scutellariae extract, parts by weight are 1～10 part Herba Andrographis extract, parts by weight are 1～10 part Herba Taraxaci extract, parts by weight are 1～10 part Radix Astragali extract, parts by weight are 1～10 part Rhizoma Phragmitis extract, parts by weight are 1～10 part Herba Lophatheri extract, parts by weight are 1～10 part Caulis Fibraureae extract, parts by weight are 1～10 part Flos Lonicerae extract, parts by weight are 1～10 part Fructus Forsythiae extract, parts by weight are the Radix Sophorae Tonkinensis extract that 1～10 part Radix Glycyrrhizae extract and the parts by weight Ramulus et Folium Picrasmae that is 1～4 part or the parts by weight Flos Carthami extract that is 1～3 part or the parts by weight Cortex Lycii extract that is 1～2 part or parts by weight are 1～2 part; Can also comprise that parts by weight are 1～10 part Radix Scutellariae extract, parts by weight are 1～10 part Herba Andrographis extract, parts by weight are 1～10 part Herba Taraxaci extract, parts by weight are 1～10 part Radix Astragali extract, parts by weight are 1～10 part Rhizoma Phragmitis extract, parts by weight are 1～10 part Herba Lophatheri extract, parts by weight are 1～10 part Caulis Fibraureae extract, parts by weight are 1～10 part Flos Lonicerae extract, parts by weight are 1～10 part Fructus Forsythiae extract, parts by weight are the Radix Sophorae Tonkinensis extract that 1～10 part Radix Glycyrrhizae extract and the parts by weight Ramulus et Folium Picrasmae that is 1～4 part and the parts by weight Flos Carthami extract that is 1～3 part or the parts by weight Cortex Lycii extract that is 1～2 part or parts by weight are 1～2 part; Can also comprise that parts by weight are 1～10 part Radix Scutellariae extract, parts by weight are 1～10 part Herba Andrographis extract, parts by weight are 1～10 part Herba Taraxaci extract, parts by weight are 1～10 part Radix Astragali extract, parts by weight are 1～10 part Rhizoma Phragmitis extract, parts by weight are 1～10 part Herba Lophatheri extract, parts by weight are 1～10 part Caulis Fibraureae extract, parts by weight are 1～10 part Flos Lonicerae extract, parts by weight are 1～10 part Fructus Forsythiae extract, parts by weight are the Radix Sophorae Tonkinensis extract that 1～10 part Radix Glycyrrhizae extract and the parts by weight Flos Carthami extract that is 1～3 part and the parts by weight Cortex Lycii extract that is 1～2 part or parts by weight are 1～2 part; Can also comprise that parts by weight are 1～10 part Radix Scutellariae extract, parts by weight are 1～10 part Herba Andrographis extract, parts by weight are 1～10 part Herba Taraxaci extract, parts by weight are 1～10 part Radix Astragali extract, parts by weight are 1～10 part Rhizoma Phragmitis extract, parts by weight are 1～10 part Herba Lophatheri extract, parts by weight are 1～10 part Caulis Fibraureae extract, parts by weight are 1～10 part Flos Lonicerae extract, parts by weight are 1～10 part Fructus Forsythiae extract, parts by weight are the Radix Sophorae Tonkinensis extract that 1～10 part Radix Glycyrrhizae extract and the parts by weight Cortex Lycii extract that is 1～2 part and parts by weight are 1～2 part; Can also comprise that parts by weight are 1～10 part Radix Scutellariae extract, parts by weight are 1～10 part Herba Andrographis extract, parts by weight are 1～10 part Herba Taraxaci extract, parts by weight are 1～10 part Radix Astragali extract, parts by weight are 1～10 part Rhizoma Phragmitis extract, parts by weight are 1～10 part Herba Lophatheri extract, parts by weight are 1～10 part Caulis Fibraureae extract, parts by weight are 1～10 part Flos Lonicerae extract, parts by weight are 1～10 part Fructus Forsythiae extract, parts by weight are the Radix Sophorae Tonkinensis extract that 1～10 part Radix Glycyrrhizae extract and the parts by weight Ramulus et Folium Picrasmae that is 1～4 part and the parts by weight Flos Carthami extract that is 1～3 part and the parts by weight Cortex Lycii extract that is 1～2 part or parts by weight are 1～2 part; Can also comprise that parts by weight are 1～10 part Radix Scutellariae extract, parts by weight are 1～10 part Herba Andrographis extract, parts by weight are 1～10 part Herba Taraxaci extract, parts by weight are 1～10 part Radix Astragali extract, parts by weight are 1～10 part Rhizoma Phragmitis extract, parts by weight are 1～10 part Herba Lophatheri extract, parts by weight are 1～10 part Caulis Fibraureae extract, parts by weight are 1～10 part Flos Lonicerae extract, parts by weight are 1～10 part Fructus Forsythiae extract, parts by weight are the Radix Sophorae Tonkinensis extract that 1～10 part Radix Glycyrrhizae extract and the parts by weight Flos Carthami extract that is 1～3 part and the parts by weight Cortex Lycii extract that is 1～2 part and parts by weight are 1～2 part; Can also comprise that parts by weight are 1～10 part Radix Scutellariae extract, parts by weight are 1～10 part Herba Andrographis extract, parts by weight are 1～10 part Herba Taraxaci extract, parts by weight are 1～10 part Radix Astragali extract, parts by weight are 1～10 part Rhizoma Phragmitis extract, parts by weight are 1～10 part Herba Lophatheri extract, parts by weight are 1～10 part Caulis Fibraureae extract, parts by weight are 1～10 part Flos Lonicerae extract, parts by weight are 1～10 part Fructus Forsythiae extract, parts by weight are the Radix Sophorae Tonkinensis extract that 1～10 part Radix Glycyrrhizae extract and the parts by weight Ramulus et Folium Picrasmae that is 1～4 part and the parts by weight Flos Carthami extract that is 1～3 part and the parts by weight Cortex Lycii extract that is 1～2 part and parts by weight are 1～2 part.
In the situation system that reproductive and respiratory syndrome does not take place animal, the use amount of the Chinese medicine composition of above-mentioned treatment high-pathogenicity blue ear disease can be reduced to 1/10～1/5 of its powder consumption and add feedstuff and be used as feed additive and use, can play preventive effect.
Below illustrate that by concrete test example the present invention treats the beneficial effect of the Chinese medicine composition of high-pathogenicity blue ear disease.
Test example 1
This experimental study the Chinese medicine composition composition powders of treatment high-pathogenicity blue ear disease of the present invention to the therapeutic effect of highly pathogenic PRRS.
1 materials and methods
1.1 experimental animal, grouping and test method
To be diagnosed as the ill pig in highly pathogenic PRRS sick pig experiment place and focus on the isolation house, 270 of the sick pigs of picked at random size and patient's condition basically identical, be divided into 9 groups, be respectively matched group, test group 1, test group 2, test group 3, test group 4, test group 5, test group 6, test group 7 and test group 8,30 every group.
The mode of spice is adopted in administration.The control group fed basal diet; Test group 1 is fed in basal diet and to be added by the prepared powder A1 of the embodiment of the invention 1, and addition is the 18kg/t basal diet; Test group 2 is fed in basal diet and to be added by the prepared powder A3 of the embodiment of the invention 3, and addition is the 18kg/t basal diet; Test group 3 is fed in basal diet and to be added by the prepared powder A4 of the embodiment of the invention 4, and addition is the 18kg/t basal diet; Test group 4 is fed in basal diet and to be added by the prepared powder A5 of the embodiment of the invention 5, and addition is the 18kg/t basal diet; Test group 5 is fed in basal diet and to be added by the prepared powder B1 of the embodiment of the invention 7, and addition is the 2kg/t basal diet; Test group 6 is fed in basal diet and to be added by the prepared powder B3 of the embodiment of the invention 7, and addition is the 2kg/t basal diet; Test group 7 is fed in basal diet and to be added by the prepared powder B4 of the embodiment of the invention 7, and addition is the 2kg/t basal diet; Test group 8 is fed in basal diet and to be added by the prepared powder B5 of the embodiment of the invention 7, and addition is a 2kg/t basis ton daily ration; Be free choice feeding, continuous use 5 days.
1.2 criterion of therapeutical effect
Cure: sick pig is after treatment, and cough, asthma, heating paresthesia disappear, and positions such as ear, mouth and nose end, root of the tail pudendum, limb end return to the normal color of pig by hyacinthine, and feces, appetite recover normal, and do not recur.
Effectively: sick pig is after treatment, it is normal that cough, asthma, heating paresthesia, spirit are progressively recovered, positions such as ear, mouth and nose end, root of the tail pudendum, limb end are returned to the normal color of pig substantially by hyacinthine, the constipation with dry stool degree is progressively improved or sick pig is fully recovered gradually, appetite increases, and recurs again in the observation period.
Invalid: after medication, sick pig symptom is not alleviated, even increases the weight of death.
2 results and analysis
The therapeutic effect of table 1 pair pig high-pathogenicity blue ear disease
| Group | Test pig | Effectively | Cure | Invalid | Effective percentage, % | Cure rate, % | Inefficiency, % |
| Matched group | 30 | 0 | 0 | 10 | 0.0 | 0.0 | 100.0 |
| Test group 1 | 30 | 4 | 25 | 1 | 13.3 | 83.3 | 3.3 |
| Test group 2 | 30 | 4 | 26 | 0 | 13.3 | 86.6 | 0.0 |
| Test group 3 | 30 | 3 | 26 | 1 | 10.0 | 93.3 | 3.3 |
| Test group 4 | 30 | 4 | 25 | 1 | 13.0 | 83.3 | 3.3 |
| Test group 5 | 30 | 3 | 27 | 0 | 10.0 | 90.0 | 0.0 |
| Test group 6 | 30 | 3 | 27 | 0 | 10.0 | 90.0 | 0.0 |
| Test group 7 | 30 | 2 | 27 | 1 | 6.7 | 93.3 | 3.3 |
| Test group 8 | 30 | 3 | 27 | 0 | 10.0 | 93.3 | 0.0 |
Result of the test sees Table 1, and the result shows that compositions of the present invention is observed treatment to 30 sick pigs, and wherein cure rate is more than 83%, and total effective rate reaches more than 96%.
Test example 2
This test example has been studied the injection, water preparation, granule of the compositions of the pathogenic reproductive and respiratory syndrome of another kind of treatment of the present invention therapeutic effect to reproductive and respiratory syndrome.
1 materials and methods
1.1 experimental animal and test method
The sick pig that the pig farm, Hebei is diagnosed as reproductive and respiratory syndrome focuses on and isolates house, chooses 80 of the sick pigs (about body weight 40kg) of picked at random size and patient's condition basically identical, is divided into 4 groups at random, i.e. matched group, test group 1, test group 2 and test group 3,20 every group.Matched group is for taking drugless medication; Test group 1 is the prescription B5 injection treatment group among the embodiment 8, every each intramuscular injection 2ml of pig, every day 2 times, logotype 3 days; Test group 2 is embodiment 9 prescription B3 water preparation treatment groups, every every day oral 10ml, every day twice, logotype 5 days; Test group 3 is embodiment 10 prescription B4 granule treatment groups, every every day oral 10g, every day 2 times, logotype 5 days.
1.2 curative effect determinate standard
Invalid: there do not have effect or DeGrain to be considered as during the treatment to be invalid.
Effectively: symptom obviously alleviates during the treatment, and recovery from illness or not recovery from illness all are considered as effectively.
Recovery from illness: sick pig returns to one's perfect health during the treatment, and spirit, appetite, defecation, body temperature etc. all recover normally to be considered as recovery from illness.
2 result of the tests
The therapeutic effect of table 2 different dosage form reproductive and respiratory syndrome
| Group | Cure a number | Cure rate (%) | Effective number | Effective percentage (%) | Invalid number | Inefficiency (%) | Mortality rate (%) |
| Matched group | - | - | - | - | - | - | 90.0 |
| Test group 1 | 18 | 90.0 | 20 | 100.0 | 0 | 0.0 | 0.0 |
| Test group 2 | 17 | 85.0 | 20 | 100.0 | 0 | 0.0 | 0.0 |
| Test group 3 | 16 | 80.0 | 19 | 95.0 | 1 | 5.0 | 5.0 |
The result shows, compares with matched group, and injection of the present invention, water preparation and granule significantly improve (P＜0.01) to the cure rate of high-pathogenicity blue ear disease, illustrates that different dosage form of the present invention has better therapeutic effect to high-pathogenicity blue ear disease.
Test example 3
This test example has been studied the preventive effect of the Chinese medicine composition of treatment high-pathogenicity blue ear disease of the present invention to highly pathogenic PRRS.
1 material and method
1.1 pathological material of disease is made
The sick Pulmonis Sus domestica hilar lymph nodes that collection is diagnosed as highly pathogenic PRRS shreds, and grinds with Potter-Elvehjem Tissue Grinders, is made into 1: 5 emulsion suspension liquid with sterile saline then.Behind the multigelation 3 times, the centrifugal 10min of 3000r/min gets supernatant and adds penicillin (100IU/mL) and streptomycin (100g/mL) solution, puts in 4 ℃ of refrigerators and acts on 12h.
1.2 experimental animal grouping
90 of the live pigs of picked at random size (about 30kg) and body condition basically identical are divided into 5 groups at random from the clinical health swinery of PRRS negative antibody test site, are respectively matched group, test group 1, test group 2, test group 3, test group 4,18 every group.Got the pathological material of disease made on the 29th day through intramuscular inoculation in test.Every pig inoculation 5mL tissue virus.
1.3 test method
The control group fed basal diet; Test group 1 is fed in basal diet and to be added by the prepared compositions A1 of the embodiment of the invention 1, and addition is the 2kg/t basal diet; Test group 2 is fed in basal diet and to be added by the prepared compositions A5 of the embodiment of the invention 5, and addition is the 2kg/t basal diet; Test group 3 is fed in basal diet and to be added by the prepared compositions B1 of the embodiment of the invention 7, and addition is the 400g/t basal diet; Test group 4 is fed in basal diet and to be added by the prepared compositions B4 of the embodiment of the invention 7, and addition is the 400g/t basal diet; Fed continuously 28 days.
1.4 preventive effect judgment criteria
Produce effects: live pig is not morbidity fully
Take effect: live pig morbidity back symptom is lighter, rehabilitation voluntarily in the observation period;
Invalid: live pig morbidity, and dead or not rehabilitation voluntarily in the observation period.
From dispensing, observed for 5 weeks continuously, respectively observe in every morning, afternoon 1 time, in time carry out observed and recorded.
2 results and analysis
The preventive effect of table 3 pair pig high-pathogenicity blue ear disease
| Group | Test pig | Take effect | Produce effects | Invalid | The rate that takes effect, % | Obvious effective rate, % | Inefficiency, % |
| Matched group | 18 | 1 | 0 | 17 | 5.6 | 0.0 | 94.4 |
| Test group 1 | 18 | 3 | 15 | 0 | 16.7 | 83.3 | 0.0 |
| Test group 2 | 18 | 1 | 17 | 0 | 5.6 | 94.4 | 0.0 |
| Test group 3 | 18 | 2 | 16 | 0 | 11.1 | 88.9 | 0.0 |
| Test group 4 | 18 | 0 | 18 | 0 | 0.0 | 100.0 | 0.0 |
The result shows that the Chinese medicine composition of treatment high-pathogenicity blue ear disease of the present invention can effectively prevent the pig high-pathogenicity blue ear disease, and obvious effective rate reaches more than 83%, and overall effective percentage reaches 100%.
Test example 4
This test example has been studied the therapeutic effect of compositions of the present invention to domestic animal animal other diseases.
Respectively asthma, pig lung plague, circovirus disease, contagious pleuropneumonia, foot and mouth disease, influenza are treated with the water preparation of prescription B1 preparation in the powder of the A1 formulation in the embodiment of the invention 1, the pre-mixing agent, the powder, the injection, embodiment 9 of B3 formulation among the embodiment 8 of B4 formulation among the embodiment 7 of A3 formulation among the embodiment 6, the granule, the pre-mixing agent of prescription B5 preparation among the embodiment 11 of prescription B2 preparation among the embodiment 10, effect is as shown in table 4.
Table 4 pair asthma, pig lung plague, rotavirus disease, circovirus disease, contagious pleuropneumonia, foot and mouth disease, grippal therapeutic effect
*Curative effect determinate standard: (1) is effective: symptom obviously alleviates during the treatment, and recovery from illness or not recovery from illness all are considered as effectively; (2) cure: sick pig returns to one's perfect health during the treatment, and spirit, appetite etc. are all recovered normally to be considered as to cure.
The result shows that compositions of the present invention all has significant curative effect to asthma, pig lung plague, circovirus disease, contagious pleuropneumonia, foot and mouth disease, influenza, and cure rate reaches more than 80%, and effective percentage reaches more than 90%.
It should be noted last that; the technical staff of the industry should understand; the foregoing description is only unrestricted in order to technical scheme of the present invention to be described; the present invention also has various changes and modifications without departing from the spirit and scope of the present invention, and these changes and improvements all fall in the claimed scope of the invention.
Claims (8)
1. Chinese medicine composition for the treatment of high-pathogenicity blue ear disease is characterized in that said composition is made up of the component of following parts by weight: 1～10 part Radix Scutellariae powder minces, 1～10 part Herba Andrographis ground product, 1～10 part Herba Taraxaci ground product, 1～10 part astragalus membranaceus powder mince, 1～10 part Rhizoma Phragmitis ground product, 1～10 part Herba Lophatheri ground product, 1～10 part Caulis Fibraureae ground product, 1～10 part Flos Lonicerae powder mince, 1～10 part Fructus Forsythiae powder minces and 1～10 part Radix Glycyrrhizae powder minces.
2. a kind of Chinese medicine composition for the treatment of high-pathogenicity blue ear disease according to claim 1, it is characterized in that also comprising that parts by weight are that 1～4 part Ramulus Et Folium Picrasmae ground product, Flos Carthami powder that parts by weight are 1～3 part mince, parts by weight are 1～2 part Cortex Lycii ground product, parts by weight are 1～2 part Radix Sophorae Tonkinensis ground product, gypsum powder that parts by weight are 1～3 part minces and parts by weight are one or more combination in 1～2 part the compound probiotic mycopowder.
3. the Chinese medicine composition of treatment high-pathogenicity blue ear disease according to claim 2, it is characterized in that described compound probiotic mycopowder is that in Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus bulgaricus, lactobacillus casei, lactobacillus lactis, enterococcus faecalis, enterococcus faecalis, pediococcus acidilactici, lactoenterococcus, bacillus acidophilus and the Lactobacillus buchneri one or more combine.
4. according to the Chinese medicine composition of claim 1,2 each described treatment high-pathogenicity blue ear diseases, it is characterized in that this pharmaceutical composition adds acceptable accessories and makes clinically or pharmaceutically acceptable dosage form, described dosage form is powder or pre-mixing agent.
5. Chinese medicine composition for the treatment of high-pathogenicity blue ear disease is characterized in that said composition is made up of the component of following parts by weight: 1～10 part Radix Scutellariae extract, 1～10 part Herba Andrographis extract, 1～10 part Herba Taraxaci extract, 1～10 part Radix Astragali extract, 1～10 part Rhizoma Phragmitis extract, 1～10 part Herba Lophatheri extract, 1～10 part Caulis Fibraureae extract, 1～10 part Flos Lonicerae extract, 1～10 part Fructus Forsythiae extract and 1～10 part Radix Glycyrrhizae extract.
6. a kind of Chinese medicine composition for the treatment of high-pathogenicity blue ear disease according to claim 5, it is characterized in that, also comprise one or more the combination in the Radix Sophorae Tonkinensis extract that parts by weight are 1～4 part Ramulus et Folium Picrasmae, Flos Carthami extract that parts by weight are 1～3 part, parts by weight are 1～2 part Cortex Lycii extract and parts by weight are 1～2 part.
7. according to claim 5 or 6 described a kind of Chinese medicine compositions for the treatment of high-pathogenicity blue ear disease, it is characterized in that, described compositions is above-mentioned Chinese medicine through fully mixing after effective component extracting, the drying respectively, or after the mixed extraction, refining, concentrate, drying forms.
8. according to the Chinese medicine composition of claim 5,6 each described treatment high-pathogenicity blue ear diseases, it is characterized in that this pharmaceutical composition adds acceptable accessories and makes clinically or pharmaceutically acceptable dosage form, described dosage form is injection, powder, water preparation, pre-mixing agent or granule.
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