CN102228636B - Traditional Chinese medicine compositions for treating highly pathogenic reproductive and respiratory syndrome (PRRS) - Google Patents
Traditional Chinese medicine compositions for treating highly pathogenic reproductive and respiratory syndrome (PRRS) Download PDFInfo
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Abstract
Belonging to the field of traditional Chinese veterinary medicine, the invention discloses two traditional Chinese medicine compositions for treating highly pathogenic reproductive and respiratory syndrome. Wherein, one composition is mainly composed of crushed scutellaria, crushed andrographis paniculata, crushed dandelion, crushed Radix Astragali, crushed reed rhizome, crushed Herba Lopatheri,crushed herba fibraureae recisae, crushed honeysuckle, crushed forsythia and crushed licorice, and can be prepared into powder or premix. The other composition mainly consists of scutellaria extract, andrographis paniculata extract, dandelion extract, Radix Astragali extract, reed rhizome extract, Herba Lopatheri extract, herba fibraureae recisae extract, honeysuckle extract, forsythia extract and licorice extract, and can be prepared into injection, powder, aqueous agent, particulate agent or premix. The compositions of the invention have scientifically and reasonably proportioned materials, and the effective components can present increased curative effect through synergy. Thus, symptoms caused by highly pathogenic reproductive and respiratory syndrome can be alleviated and treated in different links. Able to address both the symptoms and root causes, the traditional Chinese medicine compositions of the invention have high cure rate, obvious curative effect, abundant medicine source, simple process, low cost, no medicine residue, and little toxic and side effect.
Description
Technical field
The invention belongs to field of traditional Chinese veterinary, relate to a kind of Chinese medicine composition for the treatment of high-pathogenicity blue ear disease.
Breeding and breathing syndrome (PRRS) be by PRRS virus cause a kind of take breeding difficulty and respiratory symptom as the infectious disease of principal character, be commonly called as " reproductive and respiratory syndrome ".Since China's outburst, this disease occured in national each province in succession from highly pathogenic PRRS in 2006.This disease has morbidity suddenly, propagates rapidly, and popular extensively sickness rate is high, and the dead rear septicemia that is changes more; But with the easy infection of interior piglet, the farrowing sow later stage miscarriage occurs, produces stillborn fetus, weak son and mummy tire with in-pig and 1 monthly age; The characteristics such as control is difficult, and economic loss is large.The sickness rate of reproductive and respiratory syndrome in breeding pig and sow is more than 50%, and case fatality rate is up to 50～90%, and the piglet sickness rate can reach 100%, and mortality rate can reach more than 50%, and the sow abortion ratio can reach more than 30%, and the development of pig industry in serious threat.
Should disease mainly take vaccine to prevent at present, although obtained certain effect, but still Shortcomings, control appears and phenomenon without cease.Because serotype that should disease is more, vaccine is limited by specificity, immuning failure often occurs.So, explore a kind of stable, the good method of preventing and treating of prevention effect very necessary.
In order to solve the deficiencies in the prior art, the invention provides that a kind of proportioning of selecting materials is scientific and reasonable, effect stability is reliable, the Chinese medicine composition of the treatment high-pathogenicity blue ear disease of instant effect, and its preparation method is provided.
To achieve these goals, the technical solution adopted in the present invention is as follows:
The invention provides a kind of Chinese medicine composition for the treatment of high-pathogenicity blue ear disease, it is characterized in that said composition is comprised of the component of following parts by weight: the Radix Scutellariae powder of 1～10 part minces, the Herba Andrographis ground product of 1～10 part, the Herba Taraxaci ground product of 1～10 part, the astragalus membranaceus powder of 1～10 part mince, the Rhizoma Phragmitis ground product of 1～10 part, the Herba Lophatheri ground product of 1～10 part, the Caulis Fibraureae ground product of 1～10 part, the Flos Lonicerae powder of 1～10 part mince, the Fructus Forsythiae powder of 1～10 part minces and the Radix Glycyrrhizae powder of 1～10 part minces.
Described a kind of Chinese medicine composition for the treatment of high-pathogenicity blue ear disease, characterized by further comprising parts by weight and be that the Ramulus Et Folium Picrasmae ground product of 1～4 part, Flos Carthami powder that parts by weight are 1～3 part mince, parts by weight are the Cortex Lycii ground product of 1～2 part, parts by weight are the Radix Sophorae Tonkinensis ground product of 1～2 part, gypsum powder that parts by weight are 1～3 part minces and parts by weight are one or more combination in the compound probiotic mycopowder of 1～2 part.
The Chinese medicine composition of described treatment high-pathogenicity blue ear disease, it is characterized in that, described compound probiotic mycopowder is that one or more in Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus bulgaricus, lactobacillus casei, lactobacillus lactis, enterococcus faecalis, enterococcus faecalis, pediococcus acidilactici, lactoenterococcus, bacillus acidophilus and Lactobacillus buchneri combine.
The Chinese medicine composition of described treatment high-pathogenicity blue ear disease is characterized in that this pharmaceutical composition adds pharmaceutically acceptable adjuvant to make clinically or pharmaceutically acceptable dosage form, and described dosage form is powder or pre-mixing agent.
The present invention also provides the Chinese medicine composition of another kind for the treatment of high-pathogenicity blue ear disease, it is characterized in that said composition is comprised of the component of following parts by weight: the Radix Scutellariae extract of 1～10 part, the Herba Andrographis extract of 1～10 part, the Herba Taraxaci extract of 1～10 part, the Radix Astragali extract of 1～10 part, the Rhizoma Phragmitis extract of 1～10 part, the Herba Lophatheri extract of 1～10 part, the Caulis Fibraureae extract of 1～10 part, the Flos Lonicerae extract of 1～10 part, the Fructus Forsythiae extract of 1～10 part and the Radix Glycyrrhizae extract of 1～10 part.
The Chinese medicine composition of described another kind for the treatment of high-pathogenicity blue ear disease, it is characterized in that, also comprise one or more the combination in the Radix Sophorae Tonkinensis extract that parts by weight are the Ramulus et Folium Picrasmae of 1～4 part, Flos Carthami extract that parts by weight are 1～3 part, parts by weight are 1～2 part Cortex Lycii extract and parts by weight are 1～2 part.
Extract in the Chinese medicine composition of another kind for the treatment of high-pathogenicity blue ear disease of the present invention, according to its effective ingredient character separately, through extract, concentrated, refining, drying forms, in order to reduce the loss of effective ingredient in dry run, dry spray drying or the vacuum drying of adopting.The preparation method of the Chinese medicine composition of another kind for the treatment of high-pathogenicity blue ear disease of the present invention can be that every kind of medical material extracts separately, can be also that several medical materials are mixed in proportion rear extraction simultaneously, after being preferably independent extraction, mixes in the extract ratio.
The Chinese medicine composition of another kind for the treatment of high-pathogenicity blue ear disease of the present invention is characterized in that this pharmaceutical composition adds pharmaceutically acceptable adjuvant to make clinically or pharmaceutically acceptable dosage form.Wherein, clinically or the preferred injection of pharmaceutically acceptable dosage form, powder, water preparation, pre-mixing agent or granule.
The invention provides Chinese medicine composition for the treatment of high-pathogenicity blue ear disease and preparation method thereof, have following advantage:
1, the Chinese medicine composition for the treatment of high-pathogenicity blue ear disease provided by the invention, clinical symptoms for reproductive and respiratory syndrome, adopted the Chinese herbal medicine of a large amount of heat-clearing and toxic substances removing, raising immunity of organisms to make, but the proportioning of selecting materials is scientific and reasonable, the effective ingredient Synergistic of various medicines, after body absorbs, will be from various diseases or the complication that different links is alleviated and treatment is caused by reproductive and respiratory syndrome, instant effect, evident in efficacy, cure rate is high, to such an extent as to reach real treating both the principal and secondary aspects of a disease;
2, compositions of the present invention, the medicine source is abundant, and manufacture method is simple, and cost is low, adapts to the industrial needs of scale; And easy to use, drug residue free, without any side effects, satisfy large the requirement to the animal products safety in production, market scope is wide.
3, the indication of compositions of the present invention also comprises foot and mouth disease, asthma, influenza, pig lung plague, contagious pleuropneumonia, circovirus disease.
4, compositions of the present invention also can by reducing using dosage, be used as feed additive, to reach the purpose of prevention.
By following examples, the present invention will be described more specifically, and it should be understood that described embodiment is only for the present invention is described, rather than limit the scope of the invention by any way.
The specific embodiment
5 one kinds of preparations for the treatment of the Chinese medicine composition composition powders of high-pathogenicity blue ear disease of embodiment 1～embodiment
Table 1 is a kind of concrete formula for the treatment of the Chinese medicine composition of high-pathogenicity blue ear disease of embodiment 1～embodiment 5.
5 concrete formulas of table 1 embodiment of the present invention 1～embodiment 5
A1 preparation method in embodiment 1:
(1) Radix Scutellariae, Herba Andrographis, Herba Taraxaci, the Radix Astragali, Rhizoma Phragmitis, Herba Lophatheri, Caulis Fibraureae, Flos Lonicerae, Fructus Forsythiae and the Radix Glycyrrhizae after cleaning respectively dried 5h under 40～50 ℃;
(2) Radix Scutellariae, Herba Andrographis, Herba Taraxaci, the Radix Astragali, Rhizoma Phragmitis, Herba Lophatheri, Caulis Fibraureae, Flos Lonicerae, Fructus Forsythiae and the Radix Glycyrrhizae after drying pulverized respectively, then cross 200 mesh sieves, respectively Radix Scutellariae powder mince, Herba Andrographis ground product, Herba Taraxaci ground product, astragalus membranaceus powder mince, Rhizoma Phragmitis ground product, Herba Lophatheri ground product, Caulis Fibraureae ground product, Flos Lonicerae powder mince, Fructus Forsythiae powder minces and Radix Glycyrrhizae powder minces;
(3) with parts by weight be that the Radix Scutellariae powder of 10 parts minces, parts by weight are the Herba Andrographis ground product of 5 parts, Herba Taraxaci ground product that parts by weight are 3 parts, astragalus membranaceus powder that parts by weight are 5 parts mince, parts by weight are the Rhizoma Phragmitis ground product of 2 parts, Herba Lophatheri ground product that parts by weight are 2 parts, Caulis Fibraureae ground product that parts by weight are 3 parts, Flos Lonicerae powder that parts by weight are 3 parts mince, parts by weight are that the Fructus Forsythiae powder of 2 parts minces and parts by weight are the Radix Glycyrrhizae powder of the 5 parts mix and blend 15min that minces, make the coefficient of variation of its uniformity less than 5%, get final product.
A2 preparation method in embodiment 2:
(1) Radix Scutellariae, Herba Andrographis, Herba Taraxaci, the Radix Astragali, Rhizoma Phragmitis, Herba Lophatheri, Caulis Fibraureae, Flos Lonicerae, Fructus Forsythiae, Ramulus Et Folium Picrasmae and the Radix Glycyrrhizae after cleaning respectively dried 5h under 40～50 ℃;
(2) Radix Scutellariae, Herba Andrographis, Herba Taraxaci, the Radix Astragali, Rhizoma Phragmitis, Herba Lophatheri, Caulis Fibraureae, Flos Lonicerae, Fructus Forsythiae, Ramulus Et Folium Picrasmae and the Radix Glycyrrhizae after drying pulverized respectively, then cross 300 mesh sieves, respectively Radix Scutellariae powder mince, Herba Andrographis ground product, Herba Taraxaci ground product, astragalus membranaceus powder mince, Rhizoma Phragmitis ground product, Herba Lophatheri ground product, Caulis Fibraureae ground product, Flos Lonicerae powder mince, Fructus Forsythiae powder minces, Ramulus Et Folium Picrasmae ground product and Radix Glycyrrhizae powder mince;
(3) be that the Radix Scutellariae powder of 3 parts minces with parts by weight, parts by weight are the Herba Andrographis ground product of 6 parts, parts by weight are the Herba Taraxaci ground product of 2 parts, parts by weight are that the astragalus membranaceus powder of 8 parts minces, parts by weight are the Rhizoma Phragmitis ground product of 3 parts, parts by weight are the Herba Lophatheri ground product of 1 part, parts by weight are the Caulis Fibraureae ground product of 2 parts, parts by weight are that the Flos Lonicerae powder of 2 parts minces, parts by weight are that the Fructus Forsythiae powder of 1 part minces, parts by weight are Radix Glycyrrhizae powder that the Ramulus Et Folium Picrasmae ground product of 1 part and parts by weight the are 3 parts mix and blend 12min that minces, make the coefficient of variation of its uniformity less than 5%, get final product.
A3 preparation method in embodiment 3:
(1) Radix Scutellariae, Herba Andrographis, Herba Taraxaci, the Radix Astragali, Rhizoma Phragmitis, Herba Lophatheri, Caulis Fibraureae, Flos Lonicerae, Fructus Forsythiae and the Radix Glycyrrhizae after cleaning respectively dried 5h under 40～50 ℃;
(2) Radix Scutellariae, Herba Andrographis, Herba Taraxaci, the Radix Astragali, Rhizoma Phragmitis, Herba Lophatheri, Caulis Fibraureae, Flos Lonicerae, Fructus Forsythiae and the Radix Glycyrrhizae after drying pulverized respectively, then cross 250 mesh sieves, respectively Radix Scutellariae powder mince, Herba Andrographis ground product, Herba Taraxaci ground product, astragalus membranaceus powder mince, Rhizoma Phragmitis ground product, Herba Lophatheri ground product, Caulis Fibraureae ground product, Flos Lonicerae powder mince, Fructus Forsythiae powder minces and Radix Glycyrrhizae powder minces; Gypsum powder is broken to 250 orders, obtains gypsum powder and mince;
(3) with parts by weight be that the Radix Scutellariae powder of 6 parts minces, parts by weight are the Herba Andrographis ground product of 3 parts, Herba Taraxaci ground product that parts by weight are 2 parts, astragalus membranaceus powder that parts by weight are 5 parts mince, parts by weight are the Rhizoma Phragmitis ground product of 4 parts, Herba Lophatheri ground product that parts by weight are 1 part, Caulis Fibraureae ground product that parts by weight are 3 parts, Flos Lonicerae powder that parts by weight are 5 parts mince, parts by weight are that the Fructus Forsythiae powder of 6 parts minces and parts by weight are the Radix Glycyrrhizae powder of the 2 parts mix and blend 18min that minces, make the coefficient of variation of its uniformity less than 5%, get final product.
A4 preparation method in embodiment 4:
(1) Radix Scutellariae, Herba Andrographis, Herba Taraxaci, the Radix Astragali, Rhizoma Phragmitis, Herba Lophatheri, Caulis Fibraureae, Flos Lonicerae, Fructus Forsythiae and the Radix Glycyrrhizae after cleaning respectively dried 4h under 40～50 ℃;
(2) Radix Scutellariae, Herba Andrographis, Herba Taraxaci, the Radix Astragali, Rhizoma Phragmitis, Herba Lophatheri, Caulis Fibraureae, Flos Lonicerae, Fructus Forsythiae and the Radix Glycyrrhizae after drying pulverized respectively, then cross 280 mesh sieves, respectively Radix Scutellariae powder mince, Herba Andrographis ground product, Herba Taraxaci ground product, astragalus membranaceus powder mince, Rhizoma Phragmitis ground product, Herba Lophatheri ground product, Caulis Fibraureae ground product, Flos Lonicerae powder mince, Fructus Forsythiae powder minces and Radix Glycyrrhizae powder minces; Lactobacillus casei is crushed to 280 orders, obtains the lactobacillus casei mycopowder;
(3) be that the Radix Scutellariae powder of 3 parts minces with parts by weight, parts by weight are the Herba Andrographis ground product of 3 parts, parts by weight are the Herba Taraxaci ground product of 3 parts, parts by weight are that the astragalus membranaceus powder of 3 parts minces, parts by weight are the Rhizoma Phragmitis ground product of 3 parts, parts by weight are the Herba Lophatheri ground product of 1 part, parts by weight are the Caulis Fibraureae ground product of 5 parts, parts by weight are that the Flos Lonicerae powder of 3 parts minces, parts by weight are that the Fructus Forsythiae powder of 3 parts minces, the lactobacillus casei mycopowder that parts by weight are 1 part and parts by weight are the Radix Glycyrrhizae powder of the 2 parts mix and blend 18min that minces, make the coefficient of variation of its uniformity less than 5%, get final product.
A5 preparation method in embodiment 5:
(1) Radix Scutellariae, Herba Andrographis, Herba Taraxaci, the Radix Astragali, Rhizoma Phragmitis, Herba Lophatheri, Caulis Fibraureae, Flos Lonicerae, Fructus Forsythiae, Radix Glycyrrhizae, Flos Carthami and the Radix Sophorae Tonkinensis after cleaning respectively dried 5h under 40～50 ℃;
Step 2, Radix Scutellariae, Herba Andrographis, Herba Taraxaci, the Radix Astragali, Rhizoma Phragmitis, Herba Lophatheri, Caulis Fibraureae, Flos Lonicerae, Fructus Forsythiae, Radix Glycyrrhizae, Flos Carthami and Radix Sophorae Tonkinensis after drying are pulverized respectively, then cross 220 mesh sieves, respectively Radix Scutellariae powder mince, Herba Andrographis ground product, Herba Taraxaci ground product, astragalus membranaceus powder mince, Rhizoma Phragmitis ground product, Herba Lophatheri ground product, Caulis Fibraureae ground product, Flos Lonicerae powder mince, Fructus Forsythiae powder minces, Radix Glycyrrhizae powder minces, Flos Carthami powder minces and the Radix Sophorae Tonkinensis ground product; Gypsum powder is broken to 220 orders, obtains gypsum powder and mince; Lactobacillus plantarum, enterococcus faecalis, lactobacillus lactis are crushed to respectively 220 orders, obtain respectively Lactobacillus plantarum mycopowder, enterococcus faecalis mycopowder and lactobacillus lactis mycopowder, be the lactobacillus lactis mycopowder mix and blend 15min that the Lactobacillus plantarum mycopowder of 3 parts, enterococcus faecalis mycopowder that parts by weight are 2 parts and parts by weight are 5 parts with parts by weight, obtain the compound probiotic mycopowder;
step 3, be that the Radix Scutellariae powder of 6 parts minces with parts by weight, parts by weight are the Herba Andrographis ground product of 3 parts, parts by weight are the Herba Taraxaci ground product of 5 parts, parts by weight are that the astragalus membranaceus powder of 2 parts minces, parts by weight are the Rhizoma Phragmitis ground product of 3 parts, parts by weight are the Herba Lophatheri ground product of 8 parts, parts by weight are the Caulis Fibraureae ground product of 4 parts, parts by weight are that the Flos Lonicerae powder of 1 part minces, parts by weight are that the Fructus Forsythiae powder of 4 parts minces, parts by weight are that the Radix Glycyrrhizae powder of 5 parts minces, parts by weight are that the Flos Carthami powder of 1 part minces, parts by weight are the Radix Sophorae Tonkinensis ground product of 2 parts, parts by weight are that the gypsum powder of 1 part minces and parts by weight are the compound probiotic mycopowder mix and blend 20min of 2 parts, make the coefficient of variation of its uniformity less than 5%, get final product.
Above-mentioned powder adds 1～4% in feedstuff can effectively treat high-pathogenicity blue ear disease.
6 one kinds of preparations for the treatment of the Chinese medicine composition pre-mixing agent of high-pathogenicity blue ear disease of embodiment
Raw material forms: the formula of A1 in embodiment 1～embodiment 5～No. A5
Preparation method: (1) crosses 100 mesh sieves with maize cob meal, and is standby;
(2) take medicine by above-mentioned formula, make the gross weight of medicine reach 200g, mix homogeneously, then add maize cob meal to 500g, mix homogeneously gets final product.
High-pathogenicity blue ear disease can be effectively treated in the interpolation 2.5～10% of this pre-mixing agent in feedstuff.
A kind of Chinese medicine composition of high-pathogenicity blue ear disease for the treatment of is as the application of feed additive.
In the situation that reproductive and respiratory syndrome does not occur animal, the use amount of the Chinese medicine composition of above-mentioned treatment high-pathogenicity blue ear disease can be reduced to 1/10～1/5 of powder consumption and add feedstuff to be used as feed additive to use, can play preventive effect.
The preparation of the Chinese medicine composition composition powders of the another kind for the treatment of high-pathogenicity blue ear disease of embodiment 7
The formula of the Chinese medicine composition of the another kind for the treatment of of the present invention high-pathogenicity blue ear disease sees Table 2.
The concrete formula of the Chinese medicine composition of the another kind for the treatment of of table 2 high-pathogenicity blue ear disease
The preparation method of the Chinese medicine composition composition powders of another kind for the treatment of high-pathogenicity blue ear disease:
Above-mentioned B1～No. B5 formula taken each medicine, cross 100 mesh sieves after mix homogeneously, get final product.
This powder adds 0.1～0.5% in feedstuff can effectively treat high-pathogenicity blue ear disease.
The preparation of the Chinese medicine composition composition injection of the another kind for the treatment of high-pathogenicity blue ear disease of embodiment 8
Raw material forms: the formula of B1 in embodiment 7～No. B5.
Preparation method:
(1) take each medicine by above-mentioned formula ratio, the gross weight that makes medicine is 100g;
(2) add appropriate injection water to stir and make it become suspension, add the NaOH solution of 5mol/L that medicine is dissolved fully in the situation that stir, regulate pH to 7.4;
(3) add the 10ml tween 80 in mentioned solution, add water for injection to 1000ml, add 0.1% needle-use activated carbon after stirring, heated and boiled 30min;
(4) filter, the cooling rear accent pH to 7.4 of filtrate, after-teeming is penetrated water to 1000ml; Again after the filtering with microporous membrane of 0.45 μ m, embedding in the ampere bottle, every 10ml, 105 ℃ of sterilization 25min, and get final product.
Usage and consumption: intramuscular injection, per kilogram of body weight 0.05ml, is used in conjunction 3 days at every day 1～2 time.
The preparation method of the Chinese medicine composition water preparation of the another kind for the treatment of high-pathogenicity blue ear disease of embodiment 9
Raw material forms: the formula of B1 in embodiment 7～No. B5.
Preparation method:
(1) take each medicine by formula ratio, the gross weight that makes medicine is 100g;
(2) add suitable quantity of water to stir evenly, then add the NaOH solution of appropriate 5mol/L that medicine is dissolved fully, and regulate its pH to 7.0.
(3) take the 3g sodium benzoate, add suitable quantity of water to stir and make it dissolve complete;
The PhCOONa solution that (4) will dissolve is poured drug solution into, adds the 8ml tween 80, mend to add water to 1000ml, after stirring, standing 48h under room temperature, centrifugal after, supernatant after the filtering with microporous membrane of 0.45 μ m, packing, sterilization, and get final product.
Usage and consumption: mixed drink, every 1L water 0.5～2.5ml, 5 days courses for the treatment of.
The preparation of the Chinese medicinal composition granules of the another kind for the treatment of high-pathogenicity blue ear disease of embodiment 10
Raw material forms: the formula of B1 in embodiment 7～No. B5.
Preparation method: take each extract by formula ratio, mix and cross 100 mesh sieves; Add appropriate dextrin and starch, add 60% ethanol as wetting agent, cross 20 mesh sieves and granulate; Wet granular drying, granulate detect, packing, and get final product.
Usage and consumption: water-soluble drink-service, every 1L water 0.25～5g, 5 days courses for the treatment of.
The preparation of the Chinese medicine composition pre-mixing agent of the another kind for the treatment of high-pathogenicity blue ear disease of embodiment 11
Raw material forms: the formula of B1 in embodiment 7～No. B5.
Preparation method:
(1) rice husk, wheat bran are crushed to respectively 100 orders, powdered rice hulls and wheatfeed are pressed 1: 1 mixing for standby use;
(2) take each medicine by the formula of B1～in embodiment 7 No. B5, making the medicine gross weight is 200g, mix homogeneously, then with the mixture that adds powdered rice hulls and wheat bran, add to 500g, mix homogeneously gets final product.
This pre-mixing agent adds 0.25～1.25% in feedstuff can effectively treat high-pathogenicity blue ear disease.
The Chinese medicine composition of another kind for the treatment of high-pathogenicity blue ear disease is as the application of feed additive.wherein, the Chinese medicine composition for the treatment of high-pathogenicity blue ear disease can comprise that parts by weight are the Radix Scutellariae extract of 1～10 part, parts by weight are the Herba Andrographis extract of 1～10 part, parts by weight are the Herba Taraxaci extract of 1～10 part, parts by weight are the Radix Astragali extract of 1～10 part, parts by weight are the Rhizoma Phragmitis extract of 1～10 part, parts by weight are the Herba Lophatheri extract of 1～10 part, parts by weight are the Caulis Fibraureae extract of 1～10 part, parts by weight are the Flos Lonicerae extract of 1～10 part, parts by weight are the Radix Glycyrrhizae extract that the Fructus Forsythiae extract of 1～10 part and parts by weight are 1～10 part, can also comprise that parts by weight are the Radix Scutellariae extract of 1～10 part, parts by weight are the Herba Andrographis extract of 1～10 part, parts by weight are the Herba Taraxaci extract of 1～10 part, parts by weight are the Radix Astragali extract of 1～10 part, parts by weight are the Rhizoma Phragmitis extract of 1～10 part, parts by weight are the Herba Lophatheri extract of 1～10 part, parts by weight are the Caulis Fibraureae extract of 1～10 part, parts by weight are the Flos Lonicerae extract of 1～10 part, parts by weight are the Fructus Forsythiae extract of 1～10 part, parts by weight are the Radix Glycyrrhizae extract of 1～10 part, with parts by weight be the Radix Sophorae Tonkinensis extract that the Ramulus et Folium Picrasmae of 1～4 part or the parts by weight Flos Carthami extract that is 1～3 part or the parts by weight Cortex Lycii extract that is 1～2 part or parts by weight are 1～2 part, can also comprise that parts by weight are the Radix Scutellariae extract of 1～10 part, parts by weight are the Herba Andrographis extract of 1～10 part, parts by weight are the Herba Taraxaci extract of 1～10 part, parts by weight are the Radix Astragali extract of 1～10 part, parts by weight are the Rhizoma Phragmitis extract of 1～10 part, parts by weight are the Herba Lophatheri extract of 1～10 part, parts by weight are the Caulis Fibraureae extract of 1～10 part, parts by weight are the Flos Lonicerae extract of 1～10 part, parts by weight are the Fructus Forsythiae extract of 1～10 part, parts by weight are the Radix Glycyrrhizae extract of 1～10 part, with parts by weight be the Radix Sophorae Tonkinensis extract that the Ramulus et Folium Picrasmae of 1～4 part and the parts by weight Flos Carthami extract that is 1～3 part or the parts by weight Cortex Lycii extract that is 1～2 part or parts by weight are 1～2 part, can also comprise that parts by weight are the Radix Scutellariae extract of 1～10 part, parts by weight are the Herba Andrographis extract of 1～10 part, parts by weight are the Herba Taraxaci extract of 1～10 part, parts by weight are the Radix Astragali extract of 1～10 part, parts by weight are the Rhizoma Phragmitis extract of 1～10 part, parts by weight are the Herba Lophatheri extract of 1～10 part, parts by weight are the Caulis Fibraureae extract of 1～10 part, parts by weight are the Flos Lonicerae extract of 1～10 part, parts by weight are the Fructus Forsythiae extract of 1～10 part, parts by weight are the Radix Glycyrrhizae extract of 1～10 part, with parts by weight be the Radix Sophorae Tonkinensis extract that the Flos Carthami extract of 1～3 part and the parts by weight Cortex Lycii extract that is 1～2 part or parts by weight are 1～2 part, can also comprise that parts by weight are the Radix Scutellariae extract of 1～10 part, parts by weight are the Herba Andrographis extract of 1～10 part, parts by weight are the Herba Taraxaci extract of 1～10 part, parts by weight are the Radix Astragali extract of 1～10 part, parts by weight are the Rhizoma Phragmitis extract of 1～10 part, parts by weight are the Herba Lophatheri extract of 1～10 part, parts by weight are the Caulis Fibraureae extract of 1～10 part, parts by weight are the Flos Lonicerae extract of 1～10 part, parts by weight are the Fructus Forsythiae extract of 1～10 part, parts by weight are the Radix Glycyrrhizae extract of 1～10 part, with parts by weight be the Radix Sophorae Tonkinensis extract that the Cortex Lycii extract of 1～2 part and parts by weight are 1～2 part, can also comprise that parts by weight are the Radix Scutellariae extract of 1～10 part, parts by weight are the Herba Andrographis extract of 1～10 part, parts by weight are the Herba Taraxaci extract of 1～10 part, parts by weight are the Radix Astragali extract of 1～10 part, parts by weight are the Rhizoma Phragmitis extract of 1～10 part, parts by weight are the Herba Lophatheri extract of 1～10 part, parts by weight are the Caulis Fibraureae extract of 1～10 part, parts by weight are the Flos Lonicerae extract of 1～10 part, parts by weight are the Fructus Forsythiae extract of 1～10 part, parts by weight are the Radix Glycyrrhizae extract of 1～10 part, with parts by weight be the Radix Sophorae Tonkinensis extract that the Ramulus et Folium Picrasmae of 1～4 part and the parts by weight Flos Carthami extract that is 1～3 part and the parts by weight Cortex Lycii extract that is 1～2 part or parts by weight are 1～2 part, can also comprise that parts by weight are the Radix Scutellariae extract of 1～10 part, parts by weight are the Herba Andrographis extract of 1～10 part, parts by weight are the Herba Taraxaci extract of 1～10 part, parts by weight are the Radix Astragali extract of 1～10 part, parts by weight are the Rhizoma Phragmitis extract of 1～10 part, parts by weight are the Herba Lophatheri extract of 1～10 part, parts by weight are the Caulis Fibraureae extract of 1～10 part, parts by weight are the Flos Lonicerae extract of 1～10 part, parts by weight are the Fructus Forsythiae extract of 1～10 part, parts by weight are the Radix Glycyrrhizae extract of 1～10 part, with parts by weight be the Radix Sophorae Tonkinensis extract that the Flos Carthami extract of 1～3 part and the parts by weight Cortex Lycii extract that is 1～2 part and parts by weight are 1～2 part, can also comprise that parts by weight are the Radix Scutellariae extract of 1～10 part, parts by weight are the Herba Andrographis extract of 1～10 part, parts by weight are the Herba Taraxaci extract of 1～10 part, parts by weight are the Radix Astragali extract of 1～10 part, parts by weight are the Rhizoma Phragmitis extract of 1～10 part, parts by weight are the Herba Lophatheri extract of 1～10 part, parts by weight are the Caulis Fibraureae extract of 1～10 part, parts by weight are the Flos Lonicerae extract of 1～10 part, parts by weight are the Fructus Forsythiae extract of 1～10 part, parts by weight are the Radix Glycyrrhizae extract of 1～10 part, with parts by weight be the Radix Sophorae Tonkinensis extract that the Ramulus et Folium Picrasmae of 1～4 part and the parts by weight Flos Carthami extract that is 1～3 part and the parts by weight Cortex Lycii extract that is 1～2 part and parts by weight are 1～2 part.
The situation system of reproductive and respiratory syndrome does not occur animal, the use amount of the Chinese medicine composition of above-mentioned treatment high-pathogenicity blue ear disease can be reduced to 1/10～1/5 of its powder consumption and add feedstuff to be used as feed additive to use, can play preventive effect.
Below illustrate that by concrete test example the present invention treats the beneficial effect of the Chinese medicine composition of high-pathogenicity blue ear disease.
Test example 1
This experimental study the Chinese medicine composition composition powders for the treatment of high-pathogenicity blue ear disease of the present invention to the therapeutic effect of highly pathogenic PRRS.
1 materials and methods
1.1 experimental animal, grouping and test method
To be diagnosed as the ill pig of the sick pig field experiment of highly pathogenic PRRS and focus on the isolation house, choose at random 270 of the basically identical sick pigs of size and the patient's condition, be divided into 9 groups, be respectively matched group, test group 1, test group 2, test group 3, test group 4, test group 5, test group 6, test group 7 and test group 8,30 every group.
The mode of spice is adopted in administration.The control group fed basal diet; Test group 1 is fed and is added by the prepared powder A1 of the embodiment of the present invention 1 in basal diet, and addition is the 18kg/t basal diet; Test group 2 is fed and is added by the prepared powder A3 of the embodiment of the present invention 3 in basal diet, and addition is the 18kg/t basal diet; Test group 3 is fed and is added by the prepared powder A4 of the embodiment of the present invention 4 in basal diet, and addition is the 18kg/t basal diet; Test group 4 is fed and is added by the prepared powder A5 of the embodiment of the present invention 5 in basal diet, and addition is the 18kg/t basal diet; Test group 5 is fed and is added by the prepared powder B1 of the embodiment of the present invention 7 in basal diet, and addition is the 2kg/t basal diet; Test group 6 is fed and is added by the prepared powder B3 of the embodiment of the present invention 7 in basal diet, and addition is the 2kg/t basal diet; Test group 7 is fed and is added by the prepared powder B4 of the embodiment of the present invention 7 in basal diet, and addition is the 2kg/t basal diet; Test group 8 is fed and is added by the prepared powder B5 of the embodiment of the present invention 7 in basal diet, and addition is the basic ton of 2kg/t daily ration; Be free choice feeding, continuous use 5 days.
1.2 criterion of therapeutical effect
Cure: sick pig is after treatment, and cough, asthma, heating paresthesia disappear, and the positions such as ear, mouth and nose end, root of the tail pudendum, limb end are returned to the normal color of pig by hyacinthine, and feces, appetite recover normal, and do not recur.
Effectively: sick pig is after treatment, it is normal that cough, asthma, heating paresthesia, spirit are progressively recovered, the positions such as ear, mouth and nose end, root of the tail pudendum, limb end are returned to the normal color of pig substantially by hyacinthine, the constipation with dry stool degree is progressively improved or sick pig is fully recovered gradually, appetite increases, and recurs again in the observation period.
Invalid: after medication, sick pig symptom is not alleviated, and even increases the weight of death.
2 results and analysis
The therapeutic effect of table 1 pair pig high-pathogenicity blue ear disease
| Group | Test pig | Effectively | Cure | Invalid | Effective percentage, % | Cure rate, % | Inefficiency, % |
| Matched group | 30 | 0 | 0 | 10 | 0.0 | 0.0 | 100.0 |
| Test group 1 | 30 | 4 | 25 | 1 | 13.3 | 83.3 | 3.3 |
| Test group 2 | 30 | 4 | 26 | 0 | 13.3 | 86.6 | 0.0 |
| Test group 3 | 30 | 3 | 26 | 1 | 10.0 | 93.3 | 3.3 |
| Test group 4 | 30 | 4 | 25 | 1 | 13.0 | 83.3 | 3.3 |
| Test group 5 | 30 | 3 | 27 | 0 | 10.0 | 90.0 | 0.0 |
| Experimental group 6 | 30 | 3 | 27 | 0 | 10.0 | 90.0 | 0.0 |
| Test group 7 | 30 | 2 | 27 | 1 | 6.7 | 93.3 | 3.3 |
| Test group 8 | 30 | 3 | 27 | 0 | 10.0 | 93.3 | 0.0 |
Result of the test sees Table 1, and result shows, compositions of the present invention is observed treatment to 30 sick pigs, and wherein cure rate is more than 83%, and total effective rate reaches more than 96%.
Test example 2
This test example has been studied the injection, water preparation, granule of the compositions of the pathogenic reproductive and respiratory syndrome of another kind for the treatment of of the present invention to the therapeutic effect of reproductive and respiratory syndrome.
1 materials and methods
1.1 experimental animal and test method
The sick pig that the pig farm, Hebei is diagnosed as reproductive and respiratory syndrome focuses on the isolation house, choose and choose at random size and basically identical 80 of the sick pigs (body weight 40kg left and right) of the patient's condition, be divided at random 4 groups, i.e. matched group, test group 1, test group 2 and test group 3,20 every group.Matched group is for taking drugless medication; Test group 1 is the formula B5 injection treatment group in embodiment 8, and every each intramuscular injection 2ml of pig, is used in conjunction 3 days at every day 2 times; Test group 2 is embodiment 9 formula B3 water preparation treatment groups, every every day oral 10ml, every day twice, be used in conjunction 5 days; Test group 3 is embodiment 10 formula B4 Granules in Treating groups, every every day oral 10g, every day 2 times, be used in conjunction 5 days.
1.2 curative effect determinate standard
Invalid: as not have effect or DeGrain to be considered as during treatment invalid.
Effectively: during treatment, symptom obviously alleviates, and recovery from illness or not recovery from illness all are considered as effectively.
Recovery from illness: during treatment, sick pig returns to one's perfect health, and spirit, appetite, defecation, body temperature etc. all recover normally to be considered as recovery from illness.
2 result of the tests
The therapeutic effect of table 2 different dosage form reproductive and respiratory syndrome
| Group | Cure a number | Cure rate (%) | Effective number | Effective percentage (%) | Invalid number | Inefficiency (%) | Mortality rate (%) |
| Matched group | - | - | - | - | - | - | 90.0 |
| Test group 1 | 18 | 90.0 | 20 | 100.0 | 0 | 0.0 | 0.0 |
| Test group 2 | 17 | 85.0 | 20 | 100.0 | 0 | 0.0 | 0.0 |
| Test group 3 | 16 | 80.0 | 19 | 95.0 | 1 | 5.0 | 5.0 |
Result shows, compares with matched group, and injection of the present invention, water preparation and granule significantly improve (P＜0.01) to the cure rate of high-pathogenicity blue ear disease, illustrates that different dosage form of the present invention has therapeutic effect preferably to high-pathogenicity blue ear disease.
Test example 3
This test example has been studied the Chinese medicine composition for the treatment of high-pathogenicity blue ear disease of the present invention to the preventive effect of highly pathogenic PRRS.
1 materials and methods
1.1 pathological material of disease is made
The sick Pulmonis Sus domestica hilar lymph nodes that collection is diagnosed as highly pathogenic PRRS shreds, and grinds with Potter-Elvehjem Tissue Grinders, then is made into 1: 5 emulsion suspension liquid with sterile saline.After multigelation 3 times, the centrifugal 10min of 3000r/min gets supernatant and adds penicillin (100IU/mL) and streptomycin (100g/mL) solution, puts in 4 ℃ of refrigerators and acts on 12h.
1.2 experimental animal grouping
Choose at random 90 of the basically identical live pigs of size (approximately 30kg) and body condition from the clinical health swinery of PRRS negative antibody test site, be divided at random 5 groups, be respectively matched group, test group 1, test group 2, test group 3, test group 4,18 every group.Got the pathological material of disease made on the 29th day through intramuscular inoculation in test.Every pig inoculation 5mL tissue virus.
1.3 test method
The control group fed basal diet; Test group 1 is fed and is added by the prepared compositions A1 of the embodiment of the present invention 1 in basal diet, and addition is the 2kg/t basal diet; Test group 2 is fed and is added by the prepared compositions A5 of the embodiment of the present invention 5 in basal diet, and addition is the 2kg/t basal diet; Test group 3 is fed and is added by the prepared compositions B1 of the embodiment of the present invention 7 in basal diet, and addition is the 400g/t basal diet; Test group 4 is fed and is added by the prepared compositions B4 of the embodiment of the present invention 7 in basal diet, and addition is the 400g/t basal diet; Fed continuously 28 days.
1.4 preventive effect judgment criteria
Produce effects: live pig is not morbidity fully
Take effect: after live pig morbidity, symptom is lighter, rehabilitation voluntarily within the observation period;
Invalid: live pig morbidity, and dead or not rehabilitation voluntarily within the observation period.
From the dispensing from 5 weeks of Continuous Observation, respectively observe in every morning, afternoon 1 time, in time carry out observed and recorded.
2 results and analysis
The preventive effect of table 3 pair pig high-pathogenicity blue ear disease
| Group | Test pig | Take effect | Produce effects | Invalid | The rate that takes effect, % | Obvious effective rate, % | Inefficiency, % |
| Matched group | 18 | 1 | 0 | 17 | 5.6 | 0.0 | 94.4 |
| Test group 1 | 18 | 3 | 15 | 0 | 16.7 | 83.3 | 0.0 |
| Test group 2 | 18 | 1 | 17 | 0 | 5.6 | 94.4 | 0.0 |
| Test group 3 | 18 | 2 | 16 | 0 | 11.1 | 88.9 | 0.0 |
| Test group 4 | 18 | 0 | 18 | 0 | 0.0 | 100.0 | 0.0 |
Result shows, the Chinese medicine composition for the treatment of high-pathogenicity blue ear disease of the present invention can effectively prevent the pig high-pathogenicity blue ear disease, and obvious effective rate reaches more than 83%, and overall effective percentage reaches 100%.
Test example 4
This test example has been studied compositions of the present invention to the therapeutic effect of domestic animal animal other diseases.
Respectively asthma, pig lung plague, circovirus disease, contagious pleuropneumonia, foot and mouth disease, influenza are treated with the water preparation of formula B1 preparation in the powder of the formula preparation of the A1 in the embodiment of the present invention 1, the pre-mixing agent, the powder, the injection, embodiment 9 of B3 formula preparation in embodiment 8 of B4 formula preparation in embodiment 7 of A3 formula preparation in embodiment 6, the granule, the pre-mixing agent of formula B5 preparation in embodiment 11 of formula B2 preparation in embodiment 10, effect is as shown in table 4.
Table 4 pair asthma, pig lung plague, rotavirus disease, circovirus disease, contagious pleuropneumonia, foot and mouth disease, grippal therapeutic effect
*Curative effect determinate standard: (1) is effective: during treatment, symptom obviously alleviates, and recovery from illness or not recovery from illness all are considered as effectively; (2) cure: during treatment, sick pig returns to one's perfect health, and spirit, appetite etc. are all recovered normally to be considered as to cure.
Result shows, compositions of the present invention all has significant curative effect to asthma, pig lung plague, circovirus disease, contagious pleuropneumonia, foot and mouth disease, influenza, and cure rate reaches more than 80%, and effective percentage reaches more than 90%.
It should be noted last that; the technical staff of the industry should understand; above-described embodiment is only unrestricted in order to technical scheme of the present invention to be described; the present invention also has various changes and modifications without departing from the spirit and scope of the present invention, and these changes and improvements all fall in the claimed scope of the invention.
Claims (8)
1. Chinese medicine composition for the treatment of high-pathogenicity blue ear disease is characterized in that said composition is comprised of the component of following parts by weight: the Radix Scutellariae powder of 1～10 part minces, the Herba Andrographis ground product of 1～10 part, the Herba Taraxaci ground product of 1～10 part, the astragalus membranaceus powder of 1～10 part mince, the Rhizoma Phragmitis ground product of 1～10 part, the Herba Lophatheri ground product of 1～10 part, the Caulis Fibraureae ground product of 1～10 part, the Flos Lonicerae powder of 1～10 part mince, the Fructus Forsythiae powder of 1～10 part minces and the Radix Glycyrrhizae powder of 1～10 part minces.
2. Chinese medicine composition for the treatment of high-pathogenicity blue ear disease, it is characterized in that said composition is comprised of the component of following parts by weight: the combination of one or more in the compound probiotic mycopowder of 1～2 part and the Radix Scutellariae powder of 1～10 part mince, the Herba Andrographis ground product of 1～10 part, the Herba Taraxaci ground product of 1～10 part, the astragalus membranaceus powder of 1～10 part minces, the Rhizoma Phragmitis ground product of 1～10 part, the Herba Lophatheri ground product of 1～10 part, the Caulis Fibraureae ground product of 1～10 part, the Flos Lonicerae powder of 1～10 part minces, the Fructus Forsythiae powder of 1～10 part minces, the Radix Glycyrrhizae powder of 1～10 part minces, the Ramulus Et Folium Picrasmae ground product of 1～4 part, the Flos Carthami powder of 1～3 part minces, the Cortex Lycii ground product of 1～2 part, the Radix Sophorae Tonkinensis ground product of 1～2 part, the gypsum powder of 1～3 part minces.
3. the Chinese medicine composition for the treatment of high-pathogenicity blue ear disease according to claim 2, it is characterized in that, described compound probiotic mycopowder is that one or more in Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus bulgaricus, lactobacillus casei, lactobacillus lactis, enterococcus faecalis, enterococcus faecalis, pediococcus acidilactici, lactoenterococcus, bacillus acidophilus and Lactobacillus buchneri combine.
4. the Chinese medicine composition of the 2 described treatment high-pathogenicity blue ear diseases of any one according to claim 1,, it is characterized in that this pharmaceutical composition adds pharmaceutically acceptable adjuvant to make clinically or pharmaceutically acceptable dosage form, described dosage form is powder or pre-mixing agent.
5. a Chinese medicine composition for the treatment of high-pathogenicity blue ear disease, is characterized in that said composition is comprised of the component of following parts by weight: the Radix Scutellariae extract of 1～10 part, the Herba Andrographis extract of 1～10 part, the Herba Taraxaci extract of 1～10 part, the Radix Astragali extract of 1～10 part, the Rhizoma Phragmitis extract of 1～10 part, the Herba Lophatheri extract of 1～10 part, the Caulis Fibraureae extract of 1～10 part, the Flos Lonicerae extract of 1～10 part, the Fructus Forsythiae extract of 1～10 part and the Radix Glycyrrhizae extract of 1～10 part.
6. Chinese medicine composition for the treatment of high-pathogenicity blue ear disease, it is characterized in that said composition is comprised of the component of following parts by weight: the Radix Scutellariae extract of 1～10 part, the Herba Andrographis extract of 1～10 part, the Herba Taraxaci extract of 1～10 part, the Radix Astragali extract of 1～10 part, the Rhizoma Phragmitis extract of 1～10 part, the Herba Lophatheri extract of 1～10 part, the Caulis Fibraureae extract of 1～10 part, the Flos Lonicerae extract of 1～10 part, the Fructus Forsythiae extract of 1～10 part, the Ramulus et Folium Picrasmae of the Radix Glycyrrhizae extract of 1～10 part and 1～4 part, the Flos Carthami extract of 1～3 part, the Cortex Lycii extract of 1～2 part, the combination of one or more in the Radix Sophorae Tonkinensis extract of 1～2 part.
7. according to claim 5 or 6 described a kind of Chinese medicine compositions for the treatment of high-pathogenicity blue ear disease, it is characterized in that, described compositions is above-mentioned Chinese medicine through fully mixing after effective component extracting, drying respectively, or after mixed extraction, refining, concentrated, drying forms.
8. the Chinese medicine composition of the 6 described treatment high-pathogenicity blue ear diseases of any one according to claim 5,, it is characterized in that this pharmaceutical composition adds pharmaceutically acceptable adjuvant to make clinically or pharmaceutically acceptable dosage form, described dosage form is injection, powder, water preparation, pre-mixing agent or granule.
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| CN102579622B (en) * | 2012-03-03 | 2014-06-25 | 贵州省畜牧兽医研究所 | Chinese herbal preparation for treating haemophilusparasuis and preparation method thereof |
| CN103142702A (en) * | 2013-03-21 | 2013-06-12 | 河北科技师范学院 | Chinese herbal medicine injection liquid for treating porcine reproductive and respiratory syndrome and preparation method thereof |
| CN103479860B (en) * | 2013-09-26 | 2015-06-03 | 青岛农业大学 | Traditional Chinese medicine composition for treating PRRS (Porcine Reproductive and Respiratory Syndrome) and preparation method and application thereof |
| CN104288236A (en) * | 2014-10-11 | 2015-01-21 | 任夕德 | Veterinary Shuanghuanglian oral liquid preparation processed by using probiotics and preparation method thereof |
| CN104491505A (en) * | 2014-12-02 | 2015-04-08 | 河南牧业经济学院 | Compound fermented coptis chinensis paste and preparation method thereof |
| CN105146096B (en) * | 2015-10-09 | 2019-04-05 | 李宗森 | A kind of feed addictive preventing Porcine circovirus desease |
| CN105796978B (en) * | 2016-05-05 | 2019-12-10 | 南宁学院 | traditional Chinese medicine formula for treating porcine reproductive and respiratory syndrome, preparation method and using method |
| CN109223916A (en) * | 2018-09-30 | 2019-01-18 | 南宁学院 | A kind of preparation and preparation method thereof for preventing and treating Porcine circovirus desease |
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Address after: 100085, No. seven, 6 West Street, Miyun Economic Development Zone, Beijing Patentee after: Beijing Kang Hua distant view Science and Technology Co., Ltd. Address before: 100085, room 5, building 1, 603-1 East Road, Haidian District, Beijing Patentee before: Beijing Keepyoung Technology Co., Ltd. |
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| C56 | Change in the name or address of the patentee | ||
| CP02 | Change in the address of a patent holder |
Address after: 101500, No. seven, 6 West Street, Miyun Economic Development Zone, Beijing Patentee after: Beijing Kang Hua distant view Science and Technology Co., Ltd. Address before: 100085, No. seven, 6 West Street, Miyun Economic Development Zone, Beijing Patentee before: Beijing Kang Hua distant view Science and Technology Co., Ltd. |