CN104784265B - A kind of Chinese medicine composition for treating Porcine circovirus desease - Google Patents
A kind of Chinese medicine composition for treating Porcine circovirus desease Download PDFInfo
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- CN104784265B CN104784265B CN201510090740.3A CN201510090740A CN104784265B CN 104784265 B CN104784265 B CN 104784265B CN 201510090740 A CN201510090740 A CN 201510090740A CN 104784265 B CN104784265 B CN 104784265B
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Abstract
The present invention relates to a kind of medicine for treating Porcine circovirus desease, more particularly to a kind of Chinese medicine composition for the treatment Porcine circovirus desease being made by raw material of vegetable Chinese herbal medicine.Its bulk drug presses following proportionings：35 45 parts of giant knotweed, 5 15 parts of the capsule of weeping forsythia, 25 35 parts of the Radix Astragali, 5 15 parts of cottonrose hibiscus flower.The present invention is with antipyretic detoxicating, and tonifying Qi dissipating bind is the rules for the treatment of, and reasonable recipe, preparation technology is simple, applied widely.It is made of pure Chinese herbal medicine material, wide material sources, low cost, cure rate are high, medicine noresidue, have no toxic side effect, plant cell wall is particularly destroyed to greatest extent after ultramicro grinding, the deficiency that traditional Chinese medicine powder crude fiber content is high, active ingredient is difficult to dissolution is solved, it is easier to which pig absorbs, and with the effect of significant regulation body function, effectively treatment Porcine circovirus desease, shortens convalescence, easy to use.
Description
Technical field
The present invention relates to a kind of medicine for treating Porcine circovirus desease, more particularly to one kind is using vegetable Chinese herbal medicine as raw material system
Into treatment Porcine circovirus desease Chinese medicine composition.
Background technology
Porcine circovirus desease is called piglet multisystem exhaustion syndrome（PMWS）, declined with constitution, become thin, suffered from diarrhoea, breathed
Difficult, immunosupress and the viroid sexually transmitted disease that many cause of disease scabies secondary infections are principal character.Sick pig be mainly shown as by
Coarse, the ochrodermia of hair, hypoevolutism, weight loss, progressive emaciation, tachypnea or expiratory dyspnea, drowsiness, diarrhoea, can
Depending on mucous membrane jaundice, cough and central nervous system disorder, normal die by visitation of God, particularly body surface lymph node, inguinal lymph nodes
Enlargement；Its detailed symptom is mainly shown as 6-8 week old piglets, before and after wean, especially weans two weeks after, and skin occurs in piglet
, i.e., there are a large amount of red, aubergine spots, the general outwardly convex of these spots, matter in back, the ear portion even belly in skin lesion
Ground is harder, and the ratio of nursery house piglet cad pig is significantly improved, and shows as poor appetite, weak, Body weight loss, coughs or have sometimes
Nervous centralis rate is disorderly until heating or symptom of diarrhea, some pigs occurs in expiratory dyspnea, jaundice, enlargement of lymph nodes, part piglet
There is the conjunctivitis that comparison is special：Palpebral edema, eye discharge increases；Face, lower jaw and neck oedema；If any scabies secondary infection,
Then sick pig can behave as the thick random, arthritis by staple length, and some piglets show as skin scabies secondary infection etc..Pig circular ring virus
（PCV）It is PCV-II section Circovirus member, the virus is minimum one kind virus in animal virus, its particle diameter is
14-25 nanometers, in icosahedral symmetry, no cyst membrane, genome is sub-thread cyclic DNA virus.Pig circular ring virus（PCV）It is divided into two
Individual type, i.e. PCV-1 and PCV-2.PCV-1 can produce serum antibody to pig no pathogenicity, the more generally existing in swinery,
2 ages in days are inoculated with it and the pig in September age occurs without any clinical symptoms；PCV-2 has pathogenic to pig, and pig can be caused to fall ill,
Clinically it is mainly shown as piglet multisystem exhaustion syndrome after wean（PMWS）With pigskin inflammation and nephritic syndrome（PDNS）.
Porcine circovirus desease can occur throughout the year, piglet multisystem exhaustion syndrome after wean（PMWS）2- after main harm wean
The piglet of 3 weeks, but on the pig farm for carrying out segregated early weaning, the wean pig of 10-14 ages in days also has a sick generation, and virus can be with
Excrement and nasal secretion are excreted, through transmission, it is also possible to through placenta vertical infection piglet, morbidity and mortality
Indefinite, during in endemic conditions, morbidity and mortality are relatively low, but during acute outburst, the incidence of disease is up to 50%, and case fatality rate reaches
20%-30%；Such as with pig parvoviral or porcine reproductive and respiratory syndrome virus, streptococcus, killing property bus bacillus and aid in thermophilic more
During the mixed infections such as blood bacillus, the death rate can be higher；Resistance to cross pig depauperation, Adult Pig is generally subclinical infection, not appeared as
Any symptom and lesion.At present, western medicine is used alone, therapeutic effect is simultaneously imprecise, it is impossible to remove the toxin in sick pig body,
Even if bacterium and virus are suppressed, the toxin produced in vivo still has, and causes sick pig recurrent exerbation, sick pig is suffered a shock and dusk
Fan is dead, and traditional Chinese medical science field is also without effective treatment method.Therefore in the prior art, Porcine circovirus desease is without effective treatment side
Method, adds sick pig production performance and declines and high mortality, be particularly important effective treatment of this disease, and because PCV-2
Persistent infection so that this disease economically have bigger destructiveness.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for treating Porcine circovirus desease, by each medicine group
5 Synergy and attenuations are distributed, vivotoxin can be removed rapidly, residual is effectively reduced, reducing toxic and side effect, reduction pollution, and safety has
Effect.
The technical solution adopted for the present invention to solve the technical problems is：A kind of Chinese traditional medicine composition for treating Porcine circovirus desease
Thing, the bulk drug that its active ingredient is made is by following weight parts：35-45 parts of giant knotweed, 5-15 parts of the capsule of weeping forsythia, 25-35 parts of the Radix Astragali, wood
5-15 parts of Flos Hibisci Mutabilis.
Described various raw material optimum ratios are：40 parts of giant knotweed, 10 parts of the capsule of weeping forsythia, 30 parts of the Radix Astragali, 10 parts of cottonrose hibiscus flower.
The giant knotweed, the capsule of weeping forsythia, the Radix Astragali, the granularity of cottonrose hibiscus flower are 20-200 mesh.
The mode that feeds of Chinese medicine composition of the present invention is to admix feed or be decocted in water for oral dose, after per kilogram of body weight 0.5g decoctings
Admix in feed and offerd medicine to sick pig, be administered once daily, be used in conjunction 5 days.
The present invention pharmaceutical formulation mechanism and constituent constituent analysis be：
Giant knotweed：Mildly bitter flavor, cold nature；Return liver warp, gallbladder channel, lung channel.Removing dampness through diuresis and removing jaundice, clearing heat and detoxicating, expelling wind and removing dampness, the scattered stasis of blood is stopped
Bitterly, it is relieving cough and reducing sputum.For jaundice with damp-heat pathogen, arthralgia pain due to rheumatism, carbuncle sore tumefacting virus, abdominal mass etc..《The southern regions of the Yunnan Province book on Chinese herbal medicine》Carry giant knotweed：" all pyogenic infections are attacked,
Only have sore throat, diuresis walk channels and collaterals.Control five pouring gonorrhoeas, anal fistula, sore carbuncle etc. " modern study shows that giant knotweed has obvious antibacterial
Antivirus action.
The capsule of weeping forsythia：Bitter, cold nature；Return lung warp, the heart channel of Hang-Shaoyin, small intestinl channel.It is clearing heat and detoxicating, dispersing swelling and dissipating binds.For ulcer, scrofula,
Acute mastitis, erysipelas, anemopyretic cold, warm disease is from the beginning of warm is joined the army, hyperpyrexia polydipsia, coma hair spot, heat gonorrhea renal shutdown etc..The medicinal portion of the capsule of weeping forsythia
Divide mainly fruit, it contains forsythol, coumarin, oleanolic acid, saponin, citrin etc., with heat-clearing, removing toxic substances, dissipating bind row
The effects such as purulence.
The Radix Astragali：It is sweet, slightly warm in nature；Return lung warp, the spleen channel, Liver Channel, kidney channel.Invigorating qi for consolidating superficies, arrest sweating admittedly take off, torr sore myogenic, profit
Water is subsided a swelling；For treating treatment deficiency of vital energy weak, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, exterior deficiency spontaneous perspiration, ulcer is difficult to burst, burst for a long time and does not holds back, the deficiency of blood is withered
Huang, Heat Diabetes, chronic nephritis, albuminuria, diabetes etc..The Radix Astragali have enhancing body's immunity, liver protection, diuresis, anti-aging,
Resisting stress, step-down and wide antibacterial action, medicine-food two-purpose, in other Chinese medicines on the basis for the treatment of Porcine circovirus desease,
The Radix Astragali improves human body immune function, physical fitness.
Cottonrose hibiscus flower：It is pungent, it is mild-natured；Return lung warp, the heart channel of Hang-Shaoyin, Liver Channel.It is clearing heat and detoxicating, cooling blood and hemostasis, detumescence and apocenosis；For lung
The diseases such as heat cough, swollen ulcer drug, furunculosis, red eye, swell pain, abdominal pain diarrhea.
The beneficial effects of the invention are as follows, said medicine compatibility, the antipyretic detoxicating of giant knotweed, the capsule of weeping forsythia, Radix Astragali tonifying Qi is promoted the production of body fluid, cotton rose
Flower dissipating bind, four medicine phases 5, full side is able to treat both principal and secondary aspect of disease, strengthening vital QI to eliminate pathogenic factors, across-the-board regulation, Yin Yang balancing；Each medicine phases 5, reach jointly
Reducing fever and causing diuresis, the effect of detoxicating and resolving a mass, and QI-blood circulation in adjusting body, can with symptoms such as fast pain reliefs, recover appetite and
Digestive function.The present invention is with antipyretic detoxicating, and tonifying Qi dissipating bind is the rules for the treatment of, and reasonable recipe, preparation technology is simple, applied widely.Adopt
It is made of pure Chinese herbal medicine material, wide material sources, low cost, cure rate is high, medicine noresidue has no toxic side effect, particularly Ultramicro-powder
Plant cell wall is destroyed after broken to greatest extent, traditional Chinese medicine powder crude fiber content height, active ingredient is solved and is difficult to dissolution
Deficiency, it is easier to pig absorbs, and with the effect of significant regulation body function, effectively treats Porcine circovirus desease, shorten
It is convalescence, easy to use.
Illustrate beneficial effects of the present invention with reference to experimental data.
Experimental animal：120 sick pigs on Yantai pig farm, infection pig circular ring virus has been made a definite diagnosis through clinical and laboratory diagnosis
Disease, selected sick pig Individual Size and the state of mind are close.
Experiment material：
Experimental group：Experimental group 1,2,3,4,5 corresponds to Chinese medicine composition prepared by the embodiment of the present invention 1,2,3,4,5 respectively,
Mode is wherein fed every time to admix feed or be decocted in water for oral dose, and sick pig throwing is given in feed by being admixed after per kilogram of body weight 0.5g decoctings
Medicine, is administered once daily, and is used in conjunction 5 days.
Control group：Commercially available Radix Astragali polysaccharide injection, key component be legume astragalus mongolicus or Astragalus membranacus extract solution,
Content is to be no less than 1.0mg containing Astragaloside IV per 1ml, equivalent to 2g containing crude drug, takes intramuscular injection, each 0.15ml/kg, often
It is administered once, and is used in conjunction 5 days.
Curative effect judging standard
Cure：After 1 course for the treatment of of continuous use, various symptoms disappear, and every physical signs recovers normal, in high spirits, food
It is intended to good；
Effectively：After 1 course for the treatment of of continuous use, various symptoms are alleviated, and every physical signs is returned to normal, and spirit turns
It is good, start feed；
It is invalid：After 2 courses for the treatment of of continuous use, various symptoms are without improvement, even aggravation, the death having.
Experimental result：Refer to table 1.
As shown in Table 1, after medication 5 days, curative effect of the Chinese medicine composition of the present invention on treatment Porcine circovirus desease is than control
Group is notable, and treated effect is up to more than 90%.Sick pig is after treatment, and food-intake substantially increases, and spirit is gradually recovered.
Conclusion：Chinese medicine composition of the present invention is notable to the therapeutic effect of Porcine circovirus desease, instant effect, short
Obtain good therapeutic effect.
Application example 1：
Yantai Laishan District pig farm Landrace
This priority has 15 pigs to suffer from this disease, and its symptom of sick pig is mainly shown as 6-8 week old piglets, before and after wean especially
It is wean two weeks after, cutaneous lesions occurs in piglet, i.e., a large amount of red, aubergines occurs in back, the ear portion even belly
Spot, these spots are typically outwardly protruding, and quality is harder, and the ratio of nursery house piglet cad pig is significantly improved, and shows as appetite not
Shake, weak, Body weight loss, cough sometimes or have nervous centralis rate disorderly until expiratory dyspnea, jaundice, enlargement of lymph nodes（It can touch
Touch）, a part of pig, which there is also, to generate heat or symptom of diarrhea, and some pigs have the special conjunctivitis of comparison（Palpebral edema, eyes point
Secretions）, face, lower jaw and neck oedema.Medicine using the embodiment of the present invention 1 after per kilogram of body weight 0.5g decoctings by mixing
Enter in feed to ill pig dispensing, be administered once daily, be used in conjunction 5 days, stop suffering from diarrhoea with pig, without blood and 1 in normal, excrement of searching for food
Do not recur within individual month for criterion of cure, 15 pigs cure 14, and 1 invalid, and cure rate is 93%.
Application example 2：
Weihai Wendeng City pig farm Landrace
This priority has 30 pigs to suffer from this disease, sick pig show as poor appetite, weak, Body weight loss, sometimes cough or
There is nervous centralis rate disorderly until expiratory dyspnea, jaundice, enlargement of lymph nodes（It can touch）, a part of pig there is also heating or
Symptom of diarrhea, some pigs have the special conjunctivitis of comparison（Palpebral edema, eye discharge increase）, face, lower jaw and neck water
It is swollen.If any scabies secondary infection, then sick pig can behave as by staple length it is thick disorderly, arthritis（Streptococcus, haemophilus parasuis, mycoplasma
Scabies secondary infection）, some piglets show as skin scabies secondary infection（Such as exudative dermatitis）.Pig applies the medicine of the embodiment of the present invention 2
Admixed by per kilogram of body weight 0.5g in feed to ill pig dispensing, be administered once daily, be used in conjunction 5 days, stop suffering from diarrhoea with pig, feeding
Normally, without blood in excrement, and do not recur within 1 month for criterion of cure, 30 pigs cure 27, and 3 invalid, and cure rate is 90%.
Medicine of the present invention has no toxic side effect, easy to use.Using when, medicine of the present invention admixes feeding by per kilogram of body weight 0.5g
Pig dispensing is given in material, is administered once daily, is used in conjunction 5 days, stops suffering from diarrhoea with pig, feeding is normal, in excrement without blood be criterion of cure,
Clinical test proves that totally 45 ill pigs cure 41, and 4 invalid, and cure rate is 91%, there is unique curative effect.
The above-mentioned detailed description carried out with reference to embodiment to the Chinese medicine composition for treating Porcine circovirus desease, is illustrative
Rather than it is limited, several embodiments can be included according to limited scope, therefore do not departing from present general inventive concept
Under change and modifications, should belong within protection scope of the present invention.
Embodiment
In order to more fully understand and implement the present invention, the present invention is further illustrated with reference to preferred embodiment.
Embodiment 1
Giant knotweed 450g, capsule of weeping forsythia 150g, Radix Astragali 350g, cottonrose hibiscus flower 150g are weighed, 200 mesh are crossed after various raw materials are crushed
Sieve, is well mixed.
Embodiment 2
Giant knotweed 350g, capsule of weeping forsythia 50g, Radix Astragali 250g, cottonrose hibiscus flower 50g are weighed, 100 mesh sieves are crossed after various raw materials are crushed,
It is well mixed.
Embodiment 3
Giant knotweed 400g, capsule of weeping forsythia 100g, Radix Astragali 300g, cottonrose hibiscus flower 100g are weighed, 20 mesh sieves are crossed after various raw materials are crushed,
It is well mixed.
Embodiment 4
Giant knotweed giant knotweed 400g, capsule of weeping forsythia 100g, Radix Astragali 320g, cottonrose hibiscus flower 80g are weighed, 200 are crossed after various raw materials are crushed
Mesh sieve, is well mixed.
Embodiment 5
Giant knotweed 350g, capsule of weeping forsythia 80g, Radix Astragali 250g, cottonrose hibiscus flower 100g are weighed, 200 mesh sieves are crossed after various raw materials are crushed,
It is well mixed.
The above-mentioned detailed description carried out with reference to embodiment to the Chinese medicine composition for treating Porcine circovirus desease, is illustrative
Rather than it is limited, several embodiments can be included according to limited scope, therefore do not departing from present general inventive concept
Under change and modifications, should belong within protection scope of the present invention.
Claims (7)
1. a kind of Chinese medicine composition for treating Porcine circovirus desease, it is characterised in that the bulk drug of active ingredient is made by following
Parts by weight are：35-45 parts of giant knotweed, 5-15 parts of the capsule of weeping forsythia, 25-35 parts of the Radix Astragali, 5-15 parts of cottonrose hibiscus flower.
2. the Chinese medicine composition for the treatment of Porcine circovirus desease according to claim 1, it is characterised in that active ingredient is made
Bulk drug press following weight parts：40 parts of giant knotweed, 10 parts of the capsule of weeping forsythia, 30 parts of the Radix Astragali, 10 parts of cottonrose hibiscus flower.
3. the Chinese medicine composition for the treatment of Porcine circovirus desease according to claim 1, it is characterised in that active ingredient is made
Bulk drug press following weight：Giant knotweed 450g, capsule of weeping forsythia 150g, Radix Astragali 350g, cottonrose hibiscus flower 150g.
4. the Chinese medicine composition for the treatment of Porcine circovirus desease according to claim 1, it is characterised in that active ingredient is made
Bulk drug press following weight：Giant knotweed 350g, capsule of weeping forsythia 50g, Radix Astragali 250g, cottonrose hibiscus flower 50g.
5. the Chinese medicine composition for the treatment of Porcine circovirus desease according to claim 1, it is characterised in that active ingredient is made
Bulk drug press following weight：Giant knotweed 400g, capsule of weeping forsythia 100g, Radix Astragali 320g, cottonrose hibiscus flower 80g.
6. the Chinese medicine composition for the treatment of Porcine circovirus desease according to claim 1, it is characterised in that active ingredient is made
Bulk drug press following weight：Giant knotweed 350g, capsule of weeping forsythia 80g, Radix Astragali 250g, cottonrose hibiscus flower 100g.
7. the Chinese medicine composition for the treatment of Porcine circovirus desease according to claim 1, it is characterised in that giant knotweed, the capsule of weeping forsythia, Huang
The granularity of stilbene and cottonrose hibiscus flower is 20-200 mesh.
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| CN201510090740.3A CN104784265B (en) | 2015-02-28 | 2015-02-28 | A kind of Chinese medicine composition for treating Porcine circovirus desease |
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| CN102273568A (en) * | 2011-09-09 | 2011-12-14 | 天津盛兵旺军生猪养殖专业合作社 | Feed for improving immunity of piglets and preparation method thereof |
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| CN102273568A (en) * | 2011-09-09 | 2011-12-14 | 天津盛兵旺军生猪养殖专业合作社 | Feed for improving immunity of piglets and preparation method thereof |
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