CN105998783A - Traditional Chinese medicine oral liquid for treating hypoimmunity of chickens - Google Patents

Traditional Chinese medicine oral liquid for treating hypoimmunity of chickens Download PDF

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CN105998783A
CN105998783A CN201610399844.7A CN201610399844A CN105998783A CN 105998783 A CN105998783 A CN 105998783A CN 201610399844 A CN201610399844 A CN 201610399844A CN 105998783 A CN105998783 A CN 105998783A
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oral liquid
chinese medicine
radix
chicken
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赵成新
于忠伟
王晓艺
杨莉
迟静
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YANTAI JINHAI PHARMACEUTICAL Co Ltd
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YANTAI JINHAI PHARMACEUTICAL Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/59Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/26Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/264Aristolochia (Dutchman's pipe)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296Epimedium
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
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    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

Currently, chicken diseases are more and more complicated and increasingly difficult to treat; most chicken diseases are caused by mixed infection with a plurality of pathogens, and simple infection with only one pathogen is rare; and the major reason for mixed infection with a plurality of pathogens is hypoimmunity of chicken flocks. The invention belongs to the field of traditional Chinese medicine and specifically relates to a safe and effective traditional Chinese medicine oral liquid used for treating hypoimmunity of chickens and capable of realizing effect improvement and toxicity reduction through compatibility among medicinal components, rapidly removing toxins in the bodies of chickens, effectively reducing residues, mitigating toxic and side effect and lowering pollution. The traditional Chinese medicine comprises, by weight, 35 to 45 parts of Fangji, 5 to 15 parts of birthwort root, 25 to 35 parts of cassia twig, 5 to 15 parts of Radix Astragali, 5 to 15 parts of epicedium and 5 to 15 parts of corn silk. The Fangji, birthwort root, cassia twig, Radix Astragali, epicedium and corn silk are in the form of decoction pieces. A preparation method for the oral liquid comprises the following steps: soaking the decoction pieces in water 5 to 10 times of the decoction pieces for 30 min and then carrying out decoction for 1 h; adding water 2 to 3 times of the decoction pieces into herb residues obtained after filtering, carrying out decoction for 30 min again, carrying out filtering, combining two decoctions and concentrating the combined decoctions until each ml of the obtained decoction contains 0.5 g of the bulk drugs; and subjecting the decoction to split charging and sterilization so as to prepare the oral liquid.

Description

A kind of treat the Chinese medicine oral liquid that chicken immunity is low
Technical field
The invention belongs to the field of Chinese medicines, treat, more particularly to a kind of, the Chinese medicine oral liquid that chicken immunity is low.
Background technology
Current cultivation field causes the reason that immunity for chickens power is low mainly to have 3 aspects.
First aspect is viral element
In chickling and young chicken group, the immunosuppressant disease by different immunosuppressive virus infection inductions is more and more normal Seeing, the economic loss thereby resulted in is the most increasingly severe, mainly affects the production performance of chicken group, causes that multiple other are different Bacillary and viral secondary infection, and the reaction of specific vaccine immunity can be produced inhibitory action, as caused newcastle disease Virus, avian influenza virus vaccine antibody reduce, potent antibodies titre decreased duration.
The viral element causing immunosuppressive diseases in chickens mainly has following several.
1. marek's disease virus causes chicken bursa, thymus severe atrophy, bone marrow, various internal organs degeneration, make Immunocyte reduces in a large number, and cellular immunization and the humoral immune function of body are all severely impacted.
2. infectious bursal disease virus mainly encroaches on chicken bursa, atrophy after the swelling of fabricius bursa elder generation, the pouring in its medullary substance district Bar cytopathy and necrosis, also occur in harder's glands that plasma cell is downright bad.
3. avian leukosis virus can cause the lymphoproliferative of poultry, tumprigenicity infectious disease, and chicken is various passes in induction Optimum or the malignant tumor passed, can cause antibody response simultaneously and reduce, cause humoral immunization to suppress.
4., after chicken infects reticuloendotheliosis, spleen cell induced by tumor nectosis factor activity substantially increases, can Cause the organic change that each immune organ is serious, cause immune organ to damage, reduce the function of each immune organ of body, simultaneously After chicken infects the reticuloendotheliosis strain replicated completely, its humoral immunization reduces with cellullar immunologic response.Relevant real Test research to show, to Marek's disease virus, herpes turkey virus, Newcastle Disease after chicken infection reticuloendotheliosis strain The antibody response ability of poison reduces, and the degree of suppression is affected by Strain and dosage.
5. chicken infectious anemia infects the damage that can directly cause immunne response, and the susceptibility to antibacterial and fungal infection adds Play, the susceptibility infecting virus also increases.
6. in many birds bodies, it is found that reovirus, but only chicken and turkey occur viral arthritis after infecting And tenosynovitis, the function reduction of immune organ can be caused after morbidity, and body is easily by other factors in environment or stressors Impact.
7., during newcastle disease virus subacute infection, spleen has in cortical areas and the hair growth promoting of necrotic lesion, spleen and thymus Heart lymphocyte is destroyed and partial cavity's degeneration, the obvious degeneration in fabricius bursa medullary substance portion.
8. bird flu virus can replicate in macrophage, damages cell mitochondrial, causes cell death.
The immunosuppressive disease caused for viral element, carrying out vaccine virus immunization is to carry out this kind of disease prevention The main method of health care, but for avian leukosis, reticuloendotheliosis in the case of there is no effective vaccine control, Strengthen quarantine, eliminate after the positive chicken of detection, population is purified, thus reaches the purpose of healthy aquaculture.
Second aspect is trophic factor
The supply of nutrition is the important step of scale raising healthy aquaculture, and some of which aminoacid, vitamin and trace unit Element is Development of Immune Organs, lymphocyte differentiation, propagation, antibody and the required material of complement synthesis, necessarily causes machine if lacking Body immunity function suppresses, and is raw material as antibody (immunoglobulin) synthesis needs aminoacid, it is therefore necessary to give body abundance Forage protein;Vitamin A lacks, and digestive tract and respiratory mucosa can be made to sustain damage, and locally mucosal immune system function is low Under;Vitamin C then can the anti-stress ability of enhancing body;Mineral and trace element deficiency, can cause atrophy of immune organ, Humoral immunization and cellular immune function reduce.
Therefore, formula feed must be needed according to the growth of poultry and production in cultivation, it is ensured that body produces antibody Protein needed for Deng, it is to avoid chicken group's malnutrition or suffer from the immunologic hypofunction that chronic nutrient consumption disease is caused. When chicken group is in immunity or stress state, the addition of vitamin C, VitAVitE and selenium should be strengthened, thus reach To healthy aquaculture and prophylactic purpose.It should be noted that at this in addition to vitamin C, during other vitamin has Toxic agent amount, so chicken group intermittently to use in the case of not having disease.
3rd aspect is medicine and poisonous substance factor
Many medicines have inhibitory action to body immune system, if thiamphenicol and florfenicol are to fabricius bursa, thymus, spleen Dirty, caecum, tonsil etc. have inhibitory action, and glucocorticosteroid hormone such as dexamethasone is long-term or heavy dose uses, and can make chicken Bursa cell is dead, thus produces immunosuppressive action.
In feedstuff, add oxytetracycline if long-term, T lymphocyte can be destroyed, make chicken internal antibody be formed and be suppressed, And streptomycin, neomycin, gentamycin and kanamycin have the LT effect of suppression, antagonist generates also suppression Effect, therefore, rationally to select antibacterials clinically, and want the course for the treatment of suitably, it is to avoid life-time service according to the state of an illness.
Some poisonous substance such as aflatoxin can suppress the synthesis of avian antibodies, makes thymus, fabricius bursa, spleen atrophy, causes Immunity of organism suppresses.Now the most someone recognizes that present in the poultry feed low-level mycotoxin is likely to cause raw Produce hydraulic performance decline, immunity resistance weakened, to infectious disease and tumor reduces, and some researchs display that, mycete Toxin and immunosuppressive action are realized by suppression protein synthesis.
It addition, feeding and management not in place and occur big stress time also easily cause the decline of immunity, as hen house leads to The harmful gass such as wind is bad, great amount of carbon dioxide are accumulated, and stimulate the mucosal system such as respiratory tract, eye, all can make local mucosal system Immunologic hypofunction.When chicken group is stressed, blood pressure can gradually rise, and makes containing of Corticosteroid in blood Amount raises, and thymus, lymphoid tissue and fabricius bursa are degenerated, and causes immune organ to reduce the responsibility of antigen.Therefore, in cultivation During the comfortable environment of one peace and quiet of chicken group to be given, it is to avoid chicken group's overcrowding, improper ventilation, harmful gas are too much etc. to chicken The infringement of upper respiratory tract mucosa.
Two, the immunostimulant that scale raising is conventional.
1. Chinese herbal medicine class is applied most at present in scale raising is Chinese herbal medicine para-immunity reinforcing agent, as Herba Andrographis, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Bulbus Allii, Radix Isatidis, Herba Houttuyniae etc., all have the effect of enhancing human body immunity function, moreover it is possible to effectively press down The breeding of pathogen processed.Wherein, Echinacea is to carry out activating immune system by acting on macrophage and natural killer cell, reaches To improving the purpose of immunity of organisms, in addition, it be also widely used in the treatment virus of respiratory system, antibacterial and Fungal infection.
2. polysaccharide is in the product of polysaccharide, and current astragalus polysaccharides is that application is most, in Radix Astragali tradition QI invigorating Medicine, can mend all void, can admittedly can hold in the palm, and has the effects such as QI invigorating qi-restoratives yang invigorating, and numerous studies show Radix Astragali main component astragalus polysaccharides There is obvious immune enhancing function, it is possible to carry out immunomodulating, antitumor, antiviral, the most most importantly immunostimulant Effect, current astragalus polysaccharides is widely applied in terms of immunity improves in plant.In addition to astragalus polysaccharides, Coriolous Dersicolor (Fr.) Quel is many Sugar (PS P), lentinan also are able to be effectively improved the cellular immune function state of body;Bacteria lipopolysaccharide LPS), Tremella many Sugar can make B lymphopoiesis, promotes the secretory volume of antibody;Lycium barbarum polysaccharide can improve natural killer cell (NK) and kill Rate nearly 6%;Lentinan also can improve the killing activity of NK cell;Zymosan, Schizophyllan and bacteria lipopolysaccharide etc. can carry High macrophage phagocytic function, and find through relevant research, extract from antibacterial, fungus, yeast, lichens and higher plant Polysaccharide is respectively provided with antitumor and anti-infective effect.
3. selenium selenium is to maintain trace element necessary to body normal activities, in vivo with multiple biological activity shape Formula participates in the regulation of body different physiological roles, and one of them important function is exactly to improve the immunity of body.Research shows, Selenium affects all three regulatory mechanism that immune system is comprised, i.e. cellular immunization, humoral immunization and nonspecific immunity significantly. Selenium can also promote that lymphocyte produces antibody, makes haematogenic immunity globulin levels increase or remains normal, therefore gives swollen in clinic The appropriate selenium supplement of tumor patient, can be effectively improved patient's body's immunity, enhancing body anti-cancer and anti-cancer ability.Selenium supplement can be significantly Improve body's immunity of tumor patient, thus avoid palindromia.
4. levamisole levamisole is in addition to the parasiticide effect with wide spectrum, also has animal body well Immunoloregulation function, T lymph leukocyte is had facilitation, macrophage is also had obvious potentiation, I Just do similar test before 20 years, really can improve the immunity of body.It is however noted that, if long-term or big Dosage use can cause hepar damnification and granulocytopenia.
It addition, bacillus calmette-guerin vaccine is also a kind of nonspecific immunity strengthening agent, it can strengthen the phagocytic activity of macrophage, live Change lymphocyte, improve the cellular immunization of body and humoral immune function, be a kind of conventional immunostimulant, caused weak after Can be used for enhancing immunity.At present by having been proven in practice that it is really effective, but apply the most in test, also do not have For actual production.
In addition to above-mentioned a few para-immunity reinforcing agents, in plant, it is also possible to several immunostimulants are used in combination, As the Radix Astragali is combined with interferon, use in conjunction can improve the effect that influenza emits, and reduces sickness rate, and effect is bright Aobvious.In addition, compound slow-releasing immunostimulant also has positive effect, as by astragalus polysaccharides to improving immunity of organisms (APS), epimedium brevicornum polysaccharide, levamisole, vitamin E, sodium selenite add the granule compound slow-releasing immunity increasing that substrate is made Strong agent, preferable for improving immunity of organisms effect.
Being used alone western medicine at present, effect is the most imprecise, it is impossible to the toxin in purged body, though antibacterial and virus quilt Suppression, the toxin of internal generation still cannot be removed, and causes disease chicken disease recurrent exerbation, easily makes body shock and stupor dead Die.
Summary of the invention
The solving the technical problem that of the present invention is to provide a kind of treats the Chinese medicine oral liquid that chicken immunity is low, the present invention By each medicine components compatibility efficacy enhancing and toxicity reducing, can rapidly purged body endotoxin, effectively reduce residual, reduction toxic and side effects, reduction Pollute and safely and effectively treat the Chinese medicine oral liquid that chicken immunity is low.
The present invention is achieved through the following technical solutions:
A kind for the treatment of the Chinese medicine oral liquid that chicken immunity is low, it is made up of by weight following components: Radix Stephaniae Tetrandrae 35-45 Part, Radix Aristolochiae 5-15 part, Ramulus Cinnamomi 25-35 part, Radix Astragali 5-15 part, Herba Epimedii 5-15 part, Stigma Maydis 5-15 part.
Described various composition optimum ratio amount is: Radix Stephaniae Tetrandrae 40 parts, Radix Aristolochiae 10 parts, Ramulus Cinnamomi 30 parts, the Radix Astragali 10 parts, Herba Epimedii 10 parts, Stigma Maydis 10 parts.
Described Radix Stephaniae Tetrandrae, Radix Aristolochiae, Ramulus Cinnamomi, the Radix Astragali, Herba Epimedii, Stigma Maydis are decoction pieces, add 5-10 times of water soaking 30 minutes, decoct Boil 1 hour.After filtration, medicinal residues continue to add water 2-3 times, again decoct 30 minutes, merge twice medicinal liquid, be condensed into every milli after filtration Rise and be equivalent to former medicine 0.5 gram.After medicinal liquid subpackage, oral liquid is made in sterilizing.
The mode of throwing something and feeding of described Chinese medicine oral liquid is for admixing in feedstuff, adding in drinking-water or gavage, by per kilogram of body weight 1ml oral liquid offers medicine to ill chicken, is administered once daily, is used in conjunction 5 days.
The characteristic of medicine is as follows.
Radix Stephaniae Tetrandrae: bitter, pungent, cold.Return bladder;Lung;Spleen channel.Modern study shows, Radix stephaniae tetrandrae can substantially increase voided volume.Total alkali And fluid extract or decoct have analgesic activity.Tetrandrine has antiinflammatory action;To myocardium protected effect, coronary vasodilator can be expanded, Increase coronary flow, have notable hypotensive effect, can be to arrhythmia;Can substantially suppress platelet aggregation, moreover it is possible to promote fiber Protein dissolution, the Blood Coagulation Process that anticoagulant, enzyme caused;Experimental silicosis is had prophylactic treatment effect;Uterine contraction is had Significantly relexation;The tetrandrine of low concentration can make intestinal tension force increase, and Rythmic contractions characteristic is strengthened, and high concentration then reduces tension force Weaken Rythmic contractions characteristic;There is the effect of antibacterial and anti-ameba;Normal rat blood glucose can be made substantially to reduce, serum insulin Significantly raised;There is certain antitumor action;Immunity there is inhibitory action;There is anti-allergic effects widely.
Radix Aristolochiae: pungent, bitter, cold.Return liver, stomach warp.Suppressing the hyperactive liver pain relieving, removing toxic substances and promoting subsidence of swelling.For dizziness and headache, chest and abdomen swelling and pain, carbuncle Swollen furuncle, snake bite and insect sting.Radix Aristolochiae contains volatile oil, is mainly composed of aristolone in oil, and containing Aristolochic Acid, debilic acid, Magnoflorine, radix aristolochiae A prime and C prime etc..The hypertension that many reasons is caused by Radix Aristolochiae decoct has and substantially reduces blood pressure Effect.Magnoflorine contained by it is obvious to the hypotensive effect of renal hypertension.Radix Aristolochiae total alkali is to staphylococcus aureus and green The bacillus such as pus, large intestine, deformation have inhibitory action in various degree, and can strengthen the phagocytic of peritoneal macrophage, have enhancing to exempt from Epidemic disease function.
Ramulus Cinnamomi: pungent;Sweet;Warm in nature, return bladder warp;Heart channel;Lung meridian.Ramulus Cinnamomi energy diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, Dispersing cold for relieving pain.Main exterior syndrome due to wind-cold;Arthralgia due to cold-dampnes;Extreme cold of the limbs;Amenorrhea dysmenorrhea;Lump in the abdomen lumps;The thoracic obstruction;Cardiopalmus;Phlegm retention;Urine is not Profit.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus,
The Radix Astragali: sweet, tepor.Return lung, spleen, liver, kidney channel.The Radix Astragali has that benefiting QI for strengthening the superficies, arresting sweating be admittedly de-, torr skin ulcer granulation promoting, inducing diuresis to remove edema it Effect.Weak for treating the deficiency of vital energy, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and bursts for a long time and does not holds back, Blood deficiency and yellow complexion, interior-heat quenches one's thirst, chronic nephritis, albuminuria, diabetes etc..Radix Astragali Preparata QI invigorating invigorating middle warmer, raw by consolidating superficial resistance torr skin ulcer.
Herba Epimedii: acrid in the mouth;Sweet;Warm in nature.Return liver;Kidney channel.Kidney invigorating and YANG supporting, expelling wind and removing dampness.Control sexual impotence not lift, dribbling urination, Muscles and bones contraction is anxious, and hemiplegia, weakness of the waist and knees, rheumatic arthralgia, extremity are meciless.Herba Epimedii stem, leaf contain icariine, and leaf is still containing volatilization Oil, ceryl alcohol, 1 alkane, plant sterol, tannin, oils and fats.Fatty acid in fatty oil has Palmic acid, stearic acid, oleic acid, sub-oil Acid.Stigma Maydis: sweet in the mouth, light, property is put down.Return bladder, liver, gallbladder meridian.There is inducing diuresis to remove edema;Effect of liver heat removing function of gallbladder promoting.Main edema, urine leaching Drip, jaundice, cholecystitis, cholelithiasis, hypertension, diabetes, galactostasis.
The combination principle of Chinese medicine oral liquid is " efficacy enhancing and toxicity reducing ", therefore, and the pharmacological action that the different medicine of compatibility is embodied Also different.Said medicine compatibility, Radix Stephaniae Tetrandrae, Radix Aristolochiae, Ramulus Cinnamomi, Stigma Maydis diuretic kidney tonifying, the Radix Astragali, Herba Epimedii QI invigorating tonifying YANG, six medicines Xiang Wu, full side is able to treating both the principal and secondary aspects of a disease, strengthening vital QI to eliminate pathogenic factors, across-the-board regulation, Yin Yang balancing.
Each medicine phase 5, reaches clearing away heat and promoting diuresis jointly, the effect of detoxicating and resolving stagnation of pathogens, and adjusts internal QI-blood circulation, can be quick The symptoms such as alleviating pain, recover appetite and digestive function.
Present invention beneficial effect compared with prior art: the present invention is with diuretic kidney tonifying, QI invigorating tonifying YANG as the rule for the treatment of, and prescription closes Reason, preparation technology is simple, applied widely.The present invention uses pure Chinese medicinal herbs to make, wide material sources, low cost, and cure rate is high, Medicine noresidue, has no side effect, and is easier to chicken and absorbs after making oral liquid.There is the work significantly regulating body function With, effectively treatment chicken immunity is low, shortens convalescent period.Easy to use.Clinical trial proves, cure rate reaches more than 90%, has Unique curative effect.
Detailed description of the invention
Below in conjunction with preferred embodiment, to the detailed description of the invention provided according to the present invention, details are as follows.
Embodiment 1
By the various raw material selection decoction pieces in prescription, weigh Radix Stephaniae Tetrandrae 450g, Radix Aristolochiae 150g, Ramulus Cinnamomi 250g, Radix Astragali 100g, excessive sheep Leaves of pulse plants 100g, Stigma Maydis 150g, make oral liquid.
Embodiment 2
By the various raw material selection decoction pieces in prescription, weigh Radix Stephaniae Tetrandrae 400g, Radix Aristolochiae 100g, Ramulus Cinnamomi 250g, Radix Astragali 100g, excessive sheep Leaves of pulse plants 150g, Stigma Maydis 100g, make oral liquid.
Embodiment 3
By the various raw material selection decoction pieces in prescription, weigh Radix Stephaniae Tetrandrae 400g, Radix Aristolochiae 100g, Ramulus Cinnamomi 250g, Radix Astragali 100g, excessive sheep Leaves of pulse plants 100g, Stigma Maydis 150g, make oral liquid.
Embodiment 4
By the various raw material selection decoction pieces in prescription, weigh Radix Stephaniae Tetrandrae 450g, Radix Aristolochiae 100g, Ramulus Cinnamomi 250g, Radix Astragali 150g, excessive sheep Leaves of pulse plants 150g, Stigma Maydis 50g, make oral liquid.
Embodiment 5
By the various raw material selection decoction pieces in prescription, weigh Radix Stephaniae Tetrandrae 350g, Radix Aristolochiae 100g, Ramulus Cinnamomi 250g, Radix Astragali 150g, excessive sheep Leaves of pulse plants 150g, Stigma Maydis 150g, make oral liquid.
Clinical trial.
Application example 1:
Laishan District, Yantai chicken house white meat-type chickens
This priority have 1500 chickens to suffer from this is sick, atrophy after the swelling of fabricius bursa elder generation, the lymphocyte degeneration in its medullary substance district and necrosis, Also occur in harder's glands that plasma cell is downright bad.
The medicine of the application embodiment of the present invention 1 offers medicine to ill chicken by per kilogram of body weight 1ml oral liquid, is administered once daily, Being used in conjunction 5 days, stop diarrhoea with chicken, depletion of blood and do not recur for criterion of cure for 1 month in normal, the feces of searching for food, 1500 chickens are cured 1400,100 invalid, and cure rate is 93%.
Application example 2:
Weihai Wendeng City chicken house white meat-type chickens
This priority has 3000 chickens to suffer from this disease, and spleen has the cortical areas of necrotic lesion, spleen and thymus and germinal center to drench Bar cell is destroyed and partial cavity's degeneration, the obvious degeneration in fabricius bursa medullary substance portion.The medicine of the chicken application embodiment of the present invention 2 is by every Kg body weight 1ml oral liquid offers medicine to ill chicken, is administered once daily, is used in conjunction 5 days, stops diarrhoea with chicken, normal, feces of searching for food Middle depletion of blood, and within 1 month, do not recur for criterion of cure, 3000 chickens cure 2700, and 300 are invalid, and cure rate is 90%.
Medicine of the present invention has no side effect, easy to use.During application, medicine of the present invention by per kilogram of body weight 1ml gavage to Chicken is offerd medicine, and is administered once daily, is used in conjunction 5 days, stops diarrhoea with chicken, and in normal, the feces of searching for food, depletion of blood is criterion of cure, clinical examination Verifying bright, totally 4500 ill chickens cure 4100, and 400 invalid, and cure rate is 91%, has unique curative effect.
The above-mentioned detailed description carried out the Chinese medicine oral liquid that treatment chicken immunity is low with reference to embodiment, is illustrative Rather than determinate, can according to restriction scope list several embodiments, therefore without departing from present general inventive concept Under change and modifications, within protection scope of the present invention should being belonged to.

Claims (3)

1. treating the Chinese medicine oral liquid that chicken immunity is low, it is made up of by weight following components: Radix Stephaniae Tetrandrae 35-45 Part, Radix Aristolochiae 5-15 part, Ramulus Cinnamomi 25-35 part, Radix Astragali 5-15 part, Herba Epimedii 5-15 part, Stigma Maydis 5-15 part.
The Chinese medicine oral liquid that treatment chicken immunity the most according to claim 1 is low, its composition optimum ratio amount is: Radix Stephaniae Tetrandrae 40 parts, Radix Aristolochiae 10 parts, Ramulus Cinnamomi 30 parts, the Radix Astragali 10 parts, Herba Epimedii 10 parts, Stigma Maydis 10 parts.
The Chinese medicine oral liquid that treatment chicken immunity the most according to claim 1 is low, it is characterised in that include walking as follows Rapid: described Radix Stephaniae Tetrandrae, Radix Aristolochiae, Ramulus Cinnamomi, the Radix Astragali, Herba Epimedii, Stigma Maydis are decoction pieces, add 5-10 times of water soaking 30 minutes, decoct 1 little Time, after filtration, medicinal residues continue to add water 2-3 times, again decoct 30 minutes, merge twice medicinal liquid after filtration, are condensed into every milliliter quite In former medicine 0.5 gram, after medicinal liquid subpackage, oral liquid is made in sterilizing.
CN201610399844.7A 2016-06-08 2016-06-08 Traditional Chinese medicine oral liquid for treating hypoimmunity of chickens Pending CN105998783A (en)

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CN106728147A (en) * 2017-03-01 2017-05-31 烟台金海药业有限公司 A kind of Chinese medicine composition for treating chicken colibacillosis
CN116236440A (en) * 2023-02-23 2023-06-09 保定冀中药业有限公司 Preparation method of astragalus polysaccharide oral liquid with high immunocompetence for chickens and product thereof

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CN101491343A (en) * 2009-02-27 2009-07-29 荣基泰实业(深圳)有限公司 Health product capable of increasing human immunity and preparation method thereof
CN104324272A (en) * 2014-11-23 2015-02-04 烟台海研制药有限公司 Traditional Chinese medicine composition for treating canine parvovirus disease
CN104784265A (en) * 2015-02-28 2015-07-22 烟台金海药业有限公司 Porcine circovirus disease treating traditional Chinese medicine composition

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CN101491343A (en) * 2009-02-27 2009-07-29 荣基泰实业(深圳)有限公司 Health product capable of increasing human immunity and preparation method thereof
CN104324272A (en) * 2014-11-23 2015-02-04 烟台海研制药有限公司 Traditional Chinese medicine composition for treating canine parvovirus disease
CN104784265A (en) * 2015-02-28 2015-07-22 烟台金海药业有限公司 Porcine circovirus disease treating traditional Chinese medicine composition

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106728147A (en) * 2017-03-01 2017-05-31 烟台金海药业有限公司 A kind of Chinese medicine composition for treating chicken colibacillosis
CN116236440A (en) * 2023-02-23 2023-06-09 保定冀中药业有限公司 Preparation method of astragalus polysaccharide oral liquid with high immunocompetence for chickens and product thereof
CN116236440B (en) * 2023-02-23 2023-11-10 保定冀中药业有限公司 Preparation method of astragalus polysaccharide oral liquid with high immunocompetence for chickens and product thereof

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Application publication date: 20161012