CN103432425B - Medicinal preparation for treating tetanus of animals - Google Patents
Medicinal preparation for treating tetanus of animals Download PDFInfo
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Abstract
The invention provides a Chinese herba preparation for treating tetanus of animals. The raw material medicines of the Chinese herba preparation for treating tetanus of the animals comprise arisaema cum bile, radix angelicae, scorpion, fructus viticis, mantis egg-case, gastrodia elata, vine of multiflower knotweed, cortex acanthopanacis, cassia twig, notopterygium root, fructus cnidii, small centipeda herb, gallnut, leonurus, alternanthera nodiflora, hypericum sampsonii hance, astragalus mongholicus, peganum harmala, talinum crassifolium and liquorice. The Chinese herba preparation for treating tetanus of the animals is low in price and sufficient in raw material supply, is safe and reliable, has no side effects, has the characteristics of regulating the metabolism of an organism and balancing yin and yang, and can be used for complete regulation of nerve, body fluid and cell molecule of the organism.
Description
Technical field
The present invention relates to technical field of Chinese medicine, particularly relate to one and be used for the treatment of the tetanic pharmaceutical preparation of animal.
Background technology
Tetanus has another name called " Stretches ", is the acute poisoning sexually transmitted disease caused through wound infection by clostridium tetani, and the generation of primary disease must pass through traumatic infection, and the material usually containing clostridium tetani brood cell due to wound infection causes.This sick main manifestations Skeletal Muscle Sustained spasm and to stimulation reflex excitability increase.Clostridium tetani is also known as tetanic clostridium, and be long 4 ~ 8 μm, the elongated bacillus of wide 0.3 ~ 0.5 μm, how single existence, form brood cell in thalline one end, in drumstick shape, all flagellums can move, without pod membrane.Gram-positive, be negative after 48 h reaction, anaerobism.The antigen of clostridium tetani has somatic antigen and flagellar antigen two kinds, and somatic antigen has genus specificity, and flagellar antigen has type specificity.This bacterium is extensively present in the feces of soil, dust, corrupt mud and Livestock, when animal generation wound, wound is little and dark or by feces, sludged blood capping, or wound has aerobe co-infection, tetanus brood cell growth promoter breeding under anaerobic, produce a large amount of sphaceltoxin, hemotoxin, cause animal to fall ill.
Clostridium tetani can produce toxin in ill domestic animal body: sphaceltoxin causes ill domestic animal Skeletal Muscle Sustained spasm, increases stimulation reflex excitability, and stimulates body to produce protection antibody; Hemotoxin causes local organization solubility phase diagram, for pathogen growth breeding creates conditions.
Clostridium tetani is extensively present in soil, dust, mud and human and animal excreta, the equal susceptible of various domestic animal, wherein the most susceptible of soliped, and pig, sheep, cattle take second place.Tetanic popular in seasonal, young stock is domestic animal at advanced age more susceptible comparatively.Clostridium tetani is strict anaerobes, very fast dead after contact oxygen.
Clostridium tetani invades in ill domestic animal organizer through wound, breeds and produces toxin in a large number, thus cause morbidity in anaerobism, acid wound environment.Tetanopasmin is up to cornu ventrale medullae spinalis neurocyte by the space between peripheral nerve fiber, or arrive nervus motorius maincenter by lymph, blood, especially irreversible combination is formed with the ganglioside in brain stem nerve and ventricornu neurocyte, close myelosuppressive synapse, prevent the transmission that the normal inhibitory between upper and lower neuron is got excited, result causes reflex excitability to increase continuing spasmodic contraction with muscle.Respiratory function is upset, and then circulatory disturbance and hemodynamic upset occur, and occurs dehydration, acidosis.
The frequent heavy dose of injection tetanus toxoid antigen of the tetanic method of traditional treatment, heavy dose of blood sampling, make animal liver cell gradually degeneration necrosis occur, liver enlargement degeneration, become " Glycine max (L.) Merr. " sample, last liver edge is broken, and causes animal dead.
Holy Benevolent Prescriptions is said: " orthotonus, locked mouth can not be opened, and extremity tremble, diaphysis pain, and appearance convulsion is oblique, and this all damages in ailment said due to cold or exposure in part, therefore named tetanus.Its pathogenesis is that exopathogen stops up stagnant meridians, the four stages in the course of an epidemic febrile disease impatency is not transported, priming liver-wind, controls when dispeling the wind removing toxic substances, activating blood and promoting diuresis, relieving spasm for resuscitation, the present invention is exactly under the support of theory of Chinese medical science, and the one of proposition is used for the treatment of the tetanic Chinese medicine preparation of animal, this Chinese medicine preparation price is low, the source of goods is wide, safe and reliable, have no side effect, it is to adjust organism metabolism, and Yin Yang balancing is feature, can carry out comprehensive adjustment to the nerve of body, body fluid and group extracellular molecule.
Summary of the invention
Technical problem to be solved by this invention is to provide one and is used for the treatment of the tetanic Chinese medicine preparation of animal, its price is low, the source of goods is wide, safe and reliable, have no side effect, to adjust organism metabolism, Yin Yang balancing is feature, can carry out comprehensive adjustment to the nerve of body, body fluid and group extracellular molecule.
For solving the problems of the technologies described above, the invention provides one and be used for the treatment of the tetanic Chinese medicine preparation of animal, its crude drug comprises: Arisaema Cum Bile, the Radix Angelicae Dahuricae, Scorpio, Fructus Viticis, Ootheca Mantidis, Rhizoma Gastrodiae, Caulis Polygoni Multiflori, Cortex Acanthopancis, Ramulus Cinnamomi, Rhizoma Et Radix Notopterygii, Fructus Cnidii, Herba Centipedae, Galla Chinensis, Herba Leonuri, Herba Alternantherae sessilis, Herba Hyperici Sampsonii, the Radix Astragali, Herba pegani harmalae, Radix Talini Paniculati and Radix Glycyrrhizae.
In described Chinese medicine preparation, the weight of each crude drug is respectively Arisaema Cum Bile 35g ~ 45g, Radix Angelicae Dahuricae 55g ~ 65g, Scorpio 25g ~ 35g, Fructus Viticis 35g ~ 45g, Ootheca Mantidis 25g ~ 35g, Rhizoma Gastrodiae 45g ~ 55g, Caulis Polygoni Multiflori 25g ~ 35g, Cortex Acanthopancis 45g ~ 55g, Ramulus Cinnamomi 35g ~ 45g, Rhizoma Et Radix Notopterygii 25g ~ 35g, Fructus Cnidii 65g ~ 75g, Herba Centipedae 45g ~ 55g, Galla Chinensis 35g ~ 45g, Herba Leonuri 25g ~ 35g, Herba Alternantherae sessilis 35g ~ 45g, Herba Hyperici Sampsonii 25g ~ 35g, Radix Astragali 55g ~ 65g, Herba pegani harmalae 15g ~ 25g, Radix Talini Paniculati 35g ~ 45g and Radix Glycyrrhizae 25g ~ 35g.
In described Chinese medicine preparation, the weight of each raw material is preferably respectively Arisaema Cum Bile 38g ~ 42g further, Radix Angelicae Dahuricae 58g ~ 62g, Scorpio 28g ~ 32g, Fructus Viticis 38g ~ 42g, Ootheca Mantidis 28g ~ 32g, Rhizoma Gastrodiae 48g ~ 52g, Caulis Polygoni Multiflori 28g ~ 32g, Cortex Acanthopancis 48g ~ 52g, Ramulus Cinnamomi 38g ~ 42g, Rhizoma Et Radix Notopterygii 28g ~ 32g, Fructus Cnidii 68g ~ 72g, Herba Centipedae 48g ~ 52g, Galla Chinensis 38g ~ 42g, Herba Leonuri 28g ~ 32g, Herba Alternantherae sessilis 38g ~ 42g, Herba Hyperici Sampsonii 28g ~ 32g, Radix Astragali 58g ~ 62g, Herba pegani harmalae 18g ~ 22g, Radix Talini Paniculati 38g ~ 42g and Radix Glycyrrhizae 28g ~ 32g.
In described Chinese medicine preparation, the weight of each raw material is preferably respectively Arisaema Cum Bile 40g, Radix Angelicae Dahuricae 60g, Scorpio 30g, Fructus Viticis 40g, Ootheca Mantidis 30g, Rhizoma Gastrodiae 50g, Caulis Polygoni Multiflori 30g, Cortex Acanthopancis 50g, Ramulus Cinnamomi 40g, Rhizoma Et Radix Notopterygii 30g, Fructus Cnidii 70g, Herba Centipedae 50g, Galla Chinensis 40g, Herba Leonuri 30g, Herba Alternantherae sessilis 40g, Herba Hyperici Sampsonii 30g, Radix Astragali 60g, Herba pegani harmalae 20g, Radix Talini Paniculati 40g and Radix Glycyrrhizae 30g further.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, be specially:
Be uniformly mixed according to weight above by the raw material of described each Chinese medicine preparation, the stirring the mixture of acquisition adds the soak by water 2 hours ~ 4 hours of 10 times amount, filters, filtering residue adds the soak by water 1 hour ~ 3 hours of 6 times amount again, filter, the filtrate mixing of twice, being concentrated into crude drug concentration is 1g/ml ~ 2g/ml.
Present invention also offers one and be used for the treatment of the tetanic Chinese medicine preparation of animal, its crude drug comprises: Arisaema Cum Bile, the Radix Angelicae Dahuricae, Scorpio, Fructus Viticis, Ootheca Mantidis, Rhizoma Gastrodiae, Caulis Polygoni Multiflori, Cortex Acanthopancis, Ramulus Cinnamomi, Rhizoma Et Radix Notopterygii, Fructus Cnidii, Herba Centipedae, Galla Chinensis, Herba Leonuri, Herba Alternantherae sessilis, Herba Hyperici Sampsonii, the Radix Astragali, Herba pegani harmalae, Radix Talini Paniculati and Radix Glycyrrhizae;
The preparation method of described Chinese medicine preparation is specially, the raw material of described each Chinese medicine preparation is uniformly mixed according to weight above, stirring the mixture of obtaining adds the soak by water 2 hours ~ 4 hours of 10 times amount, filter, filtering residue adds the soak by water 1 hour ~ 3 hours of 6 times amount again, filter, the filtrate mixing of twice, being concentrated into crude drug concentration is 1g/ml ~ 2g/ml.
Chinese medicine preparation provided by the invention is soup decoct.
Chinese medicine preparation provided by the invention is used for the treatment of the tetanus of heavy livestock.
Described heavy livestock is horse, cattle, sheep.
Beneficial effect of the present invention:
Provided by the inventionly be used for the treatment of the tetanic Chinese medicine preparation of animal, its price be low, the source of goods is wide, safe and reliable, have no side effect, to adjust organism metabolism, Yin Yang balancing is feature, can carry out comprehensive adjustment to the nerve of body, body fluid and group extracellular molecule.
Detailed description of the invention
Holy Benevolent Prescriptions is said: " orthotonus, locked mouth can not be opened, and extremity tremble, diaphysis pain, and appearance convulsion is oblique, and this all damages in ailment said due to cold or exposure in part, therefore named tetanus.Chinese veterinarian thinks, tetanus system pathogenic factor to be taken advantage of a loophole intrusion space between skin and muscles through wound, and good and evil are fought mutually, healthy energy must not defend by strongly fragrant, battalion and declared logical, muscle arteries and veins to lose and support and contracture, and continue, the heresy of pathogenic wind toxic flees meridians, in liver priming liver-wind, so that there is the symptoms such as muscle spasm is arrested by force, gnathospasma, extremity are stiff in enemy intrusion or invasion.The rule for the treatment of is relieving convulsion for dispeling the wind, removing toxic substances relieving convulsion.
One is used for the treatment of the tetanic Chinese medicine preparation of animal, and its crude drug comprises: Arisaema Cum Bile, the Radix Angelicae Dahuricae, Scorpio, Fructus Viticis, Ootheca Mantidis, Rhizoma Gastrodiae, Caulis Polygoni Multiflori, Cortex Acanthopancis, Ramulus Cinnamomi, Rhizoma Et Radix Notopterygii, Fructus Cnidii, Herba Centipedae, Galla Chinensis, Herba Leonuri, Herba Alternantherae sessilis, Herba Hyperici Sampsonii, the Radix Astragali, Herba pegani harmalae, Radix Talini Paniculati and Radix Glycyrrhizae.
In described Chinese medicine preparation, the weight of each crude drug is respectively Arisaema Cum Bile 35g ~ 45g, Radix Angelicae Dahuricae 55g ~ 65g, Scorpio 25g ~ 35g, Fructus Viticis 35g ~ 45g, Ootheca Mantidis 25g ~ 35g, Rhizoma Gastrodiae 45g ~ 55g, Caulis Polygoni Multiflori 25g ~ 35g, Cortex Acanthopancis 45g ~ 55g, Ramulus Cinnamomi 35g ~ 45g, Rhizoma Et Radix Notopterygii 25g ~ 35g, Fructus Cnidii 65g ~ 75g, Herba Centipedae 45g ~ 55g, Galla Chinensis 35g ~ 45g, Herba Leonuri 25g ~ 35g, Herba Alternantherae sessilis 35g ~ 45g, Herba Hyperici Sampsonii 25g ~ 35g, Radix Astragali 55g ~ 65g, Herba pegani harmalae 15g ~ 25g, Radix Talini Paniculati 35g ~ 45g and Radix Glycyrrhizae 25g ~ 35g.
In described Chinese medicine preparation, the weight of each raw material is preferably respectively Arisaema Cum Bile 38g ~ 42g further, Radix Angelicae Dahuricae 58g ~ 62g, Scorpio 28g ~ 32g, Fructus Viticis 38g ~ 42g, Ootheca Mantidis 28g ~ 32g, Rhizoma Gastrodiae 48g ~ 52g, Caulis Polygoni Multiflori 28g ~ 32g, Cortex Acanthopancis 48g ~ 52g, Ramulus Cinnamomi 38g ~ 42g, Rhizoma Et Radix Notopterygii 28g ~ 32g, Fructus Cnidii 68g ~ 72g, Herba Centipedae 48g ~ 52g, Galla Chinensis 38g ~ 42g, Herba Leonuri 28g ~ 32g, Herba Alternantherae sessilis 38g ~ 42g, Herba Hyperici Sampsonii 28g ~ 32g, Radix Astragali 58g ~ 62g, Herba pegani harmalae 18g ~ 22g, Radix Talini Paniculati 38g ~ 42g and Radix Glycyrrhizae 28g ~ 32g.
In described Chinese medicine preparation, the weight of each raw material is preferably respectively Arisaema Cum Bile 40g, Radix Angelicae Dahuricae 60g, Scorpio 30g, Fructus Viticis 40g, Ootheca Mantidis 30g, Rhizoma Gastrodiae 50g, Caulis Polygoni Multiflori 30g, Cortex Acanthopancis 50g, Ramulus Cinnamomi 40g, Rhizoma Et Radix Notopterygii 30g, Fructus Cnidii 70g, Herba Centipedae 50g, Galla Chinensis 40g, Herba Leonuri 30g, Herba Alternantherae sessilis 40g, Herba Hyperici Sampsonii 30g, Radix Astragali 60g, Herba pegani harmalae 20g, Radix Talini Paniculati 40g and Radix Glycyrrhizae 30g further.
Each raw material pharmacology is:
Arisaema Cum Bile: bitter in the mouth, micro-pungent, cool in nature, returns lung, liver, spleen channel, has removing heat-phlegm, effect of dispelling wind and relieving convulsion, for phlegm-heat cough, coughs up phlegm yellow thick, middle wind-phlegm fan, the cards such as demented infantile convulsion.
The Radix Angelicae Dahuricae: warm in nature, acrid in the mouth, returns lung, spleen, stomach warp, has the cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, effect of detumescence and apocenosis, cures mainly headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, the cards such as scabies.
Scorpio: acrid in the mouth, property is put down, and return Liver Channel, have endogenous wind stopping spasmolytic, dispersing pathogen accumulation, effect of removing obstruction in the collateral to relieve pain, cures mainly infantile convulsion, tic spasm, and middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, the cards such as scrofula.
Fructus Viticis: acrid in the mouth, hardship, cold nature, returns bladder, liver, stomach warp, has dispelling wind and heat pathogens, effect of the clear sharp head, cures mainly anemopyretic cold headache, gingivitis, the many tear of conjunctival congestion, poor vision, the card such as to have a dizzy spell.
Ootheca Mantidis: latin name
ootheca Mantidis, salty sweet, flat, return liver, kidney, urinary bladder channel, have the kidney invigorating, astringent or styptic treatment for spontaneous sweating, the effect only lost, cure mainly the cards such as the bed-wetting of insufficiency of kidney-YANG, frequent urination at night, seminal emission premature ejaculation, sexual impotence, not only tonification but also astringent therapy are the good medicine of reinforcing the kidney and supporting YANG, controlling nocturnal emission with astringent drugs reducing urination.The solid caused emission and spermatorrhea of all kidney yang deficiencies, vital essence mistake, the enuresis, frequent micturition, sexual impotence are sterile, all can select, especially should the enuresis, frequent micturition.
Rhizoma Gastrodiae: sweet in the mouth, property are flat, enter Liver Channel, have suppressing the hyperactive liver to relieve the wind syndrome, spasmolytic, the effect of removing obstruction in the collateral to relieve pain, be mainly used in the dizzy headache of flaming up of liver-fire, the card such as strong wind tic, epilepsy that excessive rising of liver-YANG, liver-wind stirring up internally are caused.
Caulis Polygoni Multiflori: sweet in the mouth, property is put down, and GUIXIN, Liver Channel, have nourishing blood to tranquillize the mind, and effect of dispelling wind and removing obstruction in the collateral, cures mainly insomnia and dreamful sleep, blood deficiency general pain, rheumatic arthralgia; The cards such as skin pruritus, Caulis Polygoni Multiflori can be invigorated blood circulation, stimulate the menstrual flow, the detumescence of blood vessel dilating, blood circulation promoting, stimulating milk secretion.
Cortex Acanthopancis: acrid in the mouth, bitter, micro-sweet, warm in nature, enter liver, kidney channel, have wind-damp dispelling, invigorating the liver and kidney, the effect of bone and muscle strengthening, is mainly used in rheumatism and arthritis, and muscles and bones flaccidity is soft, traumatic injury, fracture, edema, fragile card of Denging.
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature, GUIXIN, lung, urinary bladder channel, have diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, the effect of dispersing cold for relieving pain, Ramulus Cinnamomi warming the meridian and promoting blood circulation, horizontal logical podomere, for affection of exogenous wind-cold exterior syndrome, no matter have antiperspirant, losslessly all can to apply, also for rheumatic arthralgia, cold syndrome of the stomach stomachache, amenorrhea, dysmenorrhea, rheumatic arthralgia, the cards such as shoulder arm podomere cold type of pain, phlegm retention syndrome and bladder water-retention, heart deficiency of spleen-YANG, retention of water-damp in the body, fullness and distention in the chest and hypochondrium, cough with dyspnea dizziness waits phlegm retention syndrome.
Rhizoma Et Radix Notopterygii: latin name
notopterygii Rhizoma et Radix,acrid in the mouth, hardship, warm in nature, enter kidney, urinary bladder channel, have effect of the cold expelling that induces sweat, expelling wind and dampness, pain relieving, have the wet exterior syndrome of wind and cold folder, disease sees that fever with aversion to cold, headache are as wrapped up in, neck rigid back pain, the cards such as limbs are heavy, and joint is ached, anemofrigid-damp arthralgia.
Fructus Cnidii: latin name
cnidii Fructus, acrid in the mouth, hardship, warm in nature, enter kidney channel, have the effect of warming the kidney to invigorate YANG, removing dampness and killing parasites, dispelling wind for relieving itching, the impotence in male caused for kidney yang deficiency, woman's cold womb are infertile, the cards such as cold-damp leukorrhagia or chills and pain of the waist and kness.
Herba Centipedae: latin name
centipedae Hebra,acrid in the mouth, warm in nature, enter lung, Liver Channel, there is cold-dispelling, clearing the nasal passage, eliminating phlegm and stopping cough, the effect of dissipating blood stasis for subsidence of swelling, for exterior syndrome due to wind-cold, nasal obstruction watery nasal discharge and nasal sinusitis, cough with copious phlegm, pertussis, the cards such as sore, carbuncle and painful swelling.
Galla Chinensis: latin name
galla Chinensis,sour in the mouth, puckery, cold in nature, return lung, large intestine, kidney channel, there is effect of astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of convergence, kidney calming, cure mainly: chronic cough of deficiency lung; Spontaneous sweating; Chronic dysentery chronic diarrhea; Proctoptosis; Seminal emission; Nebulousurine; Various hemorrhage; The cards such as carbuncle furuncle.
Herba Leonuri: latin name
leonuri Herba, bitter in the mouth, pungent, cold nature, enters liver, pericardium channel, has promoting blood flow to regulate menstruation, and effect of inducing diuresis to remove edema, cures mainly menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria, the cards such as acute nephritis edema.
Herba Alternantherae sessilis: sweet in the mouth, cold in nature, have cool the blood dissipate blood stasis, heat-clearing and toxic substances removing, dehumidify treating stranguria card such as grade, cures mainly hemoptysis, spit blood, have blood in stool, jaundice due to damp-heat, the cards such as dysentery, has loose bowels, gingival swelling and pain, laryngopharynx swelling and pain, acute mastitis, swollen ulcer drug, traumatic injury, venom.
Herba Hyperici Sampsonii: bitter in the mouth, pungent, cold in nature, return liver, spleen channel, there is removing pathogenic heat from blood and toxic substance from the body, promoting blood flow to regulate menstruation, effect of dispelling wind and removing obstruction in the collateral, cure mainly various hemorrhage, enteritis and dysentery, acute mastitis, carbuncle furunculosis, scald, venom, menoxenia, dysmenorrhea, leucorrhea, traumatic injury, rheumatic arthralgia, the cards such as aphtha.
The Radix Astragali: sweet in the mouth, warm in nature, enter spleen, lung meridian, have benefit strengthening spleen and lung, elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, the effects such as holder skin ulcer granulation promoting, are mainly used in the weak anorexia and loose stool that deficiency of both the splenic and pulmonary QI is caused, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency, the cards such as insufficiency of vital energy and blood.
Herba pegani harmalae: acrid in the mouth, hardship; Property is put down, and has relieving cough and asthma; Wind-damp dispelling; Effect of detumescence poison.Cure mainly cough and asthma; Rheumatic arthralgia; Innominate toxic swelling; The cards such as skin pruritus.
Radix Talini Paniculati: latin name
pedicularis muscicola Maxim, sweet in the mouth, micro-hardship, tool heat-clearing toxin-expelling functions, weak to the deficiency of vital energy, diarrhea due to hypofunction of the spleen, xeropulmonary cough, neurasthenia etc. have certain curative effect.Strongly invigorating primordial QI, promoting the production of body fluid and inducing sedation of the mind, heart tonifying.Control QI and blood deficient, asthenia hyperhidrosis, collapse exhaustion, blood pressure reduces.
Radix Glycyrrhizae: latin name
glycyrrhizae Radix et Rhizoma, sweet in the mouth, property put down, enter 12 warps, have heat-clearing and toxic substances removing, be in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak; Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play QI invigorating neutralization by adding Radix Glycyrrhizae, is in harmonious proportion the work of each component.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, be specially:
The raw material of described each Chinese medicine preparation is uniformly mixed according to weight above, stirring the mixture of obtaining adds the soak by water 2 hours ~ 4 hours of 10 times amount, filter, filtering residue adds the soak by water 1 hour ~ 3 hours relative to mixture quality 6 times amount again, filter, the filtrate mixing of twice, being concentrated into crude drug concentration is 1g/ml ~ 2g/ml.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine preparation 1
Arisaema Cum Bile 40g, Radix Angelicae Dahuricae 60g, Scorpio 30g, Fructus Viticis 40g, Ootheca Mantidis 30g, Rhizoma Gastrodiae 50g, Caulis Polygoni Multiflori 30g, Cortex Acanthopancis 50g, Ramulus Cinnamomi 40g, Rhizoma Et Radix Notopterygii 30g, Fructus Cnidii 70g, Herba Centipedae 50g, Galla Chinensis 40g, Herba Leonuri 30g, Herba Alternantherae sessilis 40g, Herba Hyperici Sampsonii 30g, Radix Astragali 60g, Herba pegani harmalae 20g, Radix Talini Paniculati 40g and Radix Glycyrrhizae 30g are uniformly mixed, stirring the mixture of obtaining adds the soak by water 4 hours of 8kg, filter, filtering residue adds the soak by water 3 hours of 6kg again, filter, the filtrate mixing of twice, being concentrated into crude drug concentration is 1g/ml.
Embodiment 2 Chinese medicine preparation 2
Arisaema Cum Bile 38g, Radix Angelicae Dahuricae 58g, Scorpio 28g, Fructus Viticis 38g, Ootheca Mantidis 28g, Rhizoma Gastrodiae 48g, Caulis Polygoni Multiflori 28g, Cortex Acanthopancis 48g, Ramulus Cinnamomi 38g, Rhizoma Et Radix Notopterygii 28g, Fructus Cnidii 68g, Herba Centipedae 48g, Galla Chinensis 38g, Herba Leonuri 28g, Herba Alternantherae sessilis 38g, Herba Hyperici Sampsonii 28g, Radix Astragali 58g, Herba pegani harmalae 18g, Radix Talini Paniculati 38g and Radix Glycyrrhizae 28g are uniformly mixed, stirring the mixture of obtaining adds the soak by water 4 hours of 8kg, filter, filtering residue adds the soak by water 3 hours of 6kg again, filter, the filtrate mixing of twice, being concentrated into crude drug concentration is 2g/ml.
Embodiment 3 Chinese medicine preparation 3
Arisaema Cum Bile 42g, Radix Angelicae Dahuricae 62g, Scorpio 32g, Fructus Viticis 42g, Ootheca Mantidis 32g, Rhizoma Gastrodiae 52g, Caulis Polygoni Multiflori 32g, Cortex Acanthopancis 52g, Ramulus Cinnamomi 42g, Rhizoma Et Radix Notopterygii 32g, Fructus Cnidii 72g, Herba Centipedae 52g, Galla Chinensis 42g, Herba Leonuri 32g, Herba Alternantherae sessilis 42g, Herba Hyperici Sampsonii 32g, Radix Astragali 62g, Herba pegani harmalae 22g, Radix Talini Paniculati 42g and Radix Glycyrrhizae 32g are uniformly mixed, stirring the mixture of obtaining adds the soak by water 4 hours of 8kg, filter, filtering residue adds the soak by water 3 hours of 6kg again, filter, the filtrate mixing of twice, being concentrated into crude drug concentration is 1g/ml.
Animal experiment study
Laboratory animal: regular grade Kun Ming mice, after laboratory feeds 1 week, average weight 29. 0g.
Experimental drug: Chinese medicinal decoction decoct prepared by the embodiment of the present invention 1.
Experimental technique
The foundation of tetanus animal model: (1) is separated clostridium tetani from earth, after purifying, is inoculated into Anaerobic culturel 15d in cooked meat medium, and after getting supernatant bacteriological filtration, obtain tetanopasmin, refrigerator freezing is preserved, for subsequent use.(2) 90 white mice SPSS11. 0 statistical software is divided into 3 groups at random, often organizes 30.To experiment 1 group and experiment 2 groups of Chinese medicine (0.5ml) gavages, then respectively at after 50min and 120min, left hind root intramuscular injection tetanopasmin, dosage is [Mouse Weight (g)/100+0. 06] ml.Left hind root intramuscular injection tetanopasmin after matched group (B group) normal saline (0. 5ml) gavage 50min, dosage is the same.
Observed and recorded: carry out observed and recorded according to the observation index made in advance.Observation index has 48h mortality rate, final mortality rate (the 5th day mice to experiment is only dead without continuation), injection toxin 2 disease time, morbidity persistent period, spasm intensity [being divided into four grades: without obvious spasm (-), slight spasm (+), moderate spasm (++), strong spasm (+++)].In order to avoid the difference of observer's record, before experiment, training is unified to observer, use unified conventional letter, and use unified symptom intensity record index.
Date processing: data statistics Using statistics software SPSS11. 0 carries out X 2 test and t inspection, and judged result has not statistically significant.
Result
Each group of death condition statistics, the results are shown in Table 1.
Table 1 is group death condition statistics respectively
| Group | Sum | 48h death toll | 48h mortality rate (%) | Final death toll | Final mortality rate (%) |
| Test 1 group | 30 | 3 | 10 | 8 | 26.7 |
| Test 2 groups | 30 | 5 | 16.7 | 10 | 33.3 |
| Matched group B | 30 | 16 | 53.3 | 28 | 93.3 |
Each group of spasm intensity statistics, the results are shown in Table 2.
Table 2 is the intensity statistics of group spasm respectively
| Group | Sum | - | + | ++ | +++ |
| Test 1 group | 30 | 13 | 9 | 5 | 4 |
| Test 2 groups | 30 | 12 | 10 | 3 | 5 |
| Matched group B | 30 | 6 | 5 | 7 | 12 |
Each group of injection toxin-disease time, morbidity duration statistics, the results are shown in Table 3.
Table 3 is group injection toxin-disease time, morbidity duration statistics respectively
| Group | Injection toxin-disease time (min) | Morbidity persistent period (min) |
| Test 1 group | 23.1 +5.2 | 26.3 +4.9 |
| Test 2 groups | 20.9 +5.7 | 29.3 +6.2 |
| Matched group B | 13.7 +3.3 | 36.2 +3.9 |
Table 1 shows, test group is compared with matched group, 48h mortality rate and final mortality rate all there is obvious minimizing, test group mice spasm intensity is less than matched group, injection toxin-disease time is longer than matched group, and morbidity persistent period phrase matched group, illustrates that this Chinese medicine can reduce the tetanic mortality rate of white mice, obvious improve white mice tetanus morbidity intensity and delay disease time, and can shorten fall ill the persistent period.
Exemplary 1
On May 27th, 2010, a mare of Zhang family, red, eight years old age, be in foal four months, because scapular region wound causes tetanus by ailment said due to cold or exposure invasion and attack, oxidant disinfectant 3% hydrogen peroxide is selected thoroughly to clean wound, remove pus, foreign body, secretions and slough, every day with 5% iodine tincture disinfection once, through treatment three days, curative effect is loseed with crossing tetanus antitoxin 800,000 unit, clinical symptoms, body temperature 38.5 DEG C, breathe 30/minute, 50 beats/min, pulse, gnathospasma, two fingers can be held, there is short time spasm occasionally, item neck rigidity back of the body waist is stiff, though tail is hard but end is straight rises, walking extremity are nonvoluntary, more stiff, see object eye suddenly to show money or valuables one carries unintentionally, the accentuation of cardiac sound, pulse condition is number tightly, colour of the tongue is crimson, oral cavity stream has sticky saliva, forage can not be chewed, drinking-water dysphagia, gastrointestinal pitch youth, in every day with on 5% iodine tincture disinfection basis once, the Chinese medicine composition soup decoct using the embodiment of the present invention 1 preparation instead gavages, every day 2 doses, sooner or later each 1 dose, each 500ml, strengthen feeding and management, trouble horse is raised separately in peace and quiet, dark, spacious, do not have in the stable of foreign material, avoid various environmental stimuli as far as possible.For avoiding traumatic injury, getting the support of stance suspender belt and being fixed in 6 post hurdles; 2nd afternoon, suffers from horse opening successor by its grass that searches for food.Added Sal and malt sugar medicated porridge to trouble horse polydipsia.Every day, timing was walked a horse, and increased motion, promoted that muscle function recovers, but unsuitable tired.
Ill horse is at treatment the 2nd day opening drinking-water; Within 3rd day, spasm is eliminated, and symptom obviously alleviates; Substantially eliminate to the 7th day General Symptoms.Continue medication 4 d, General Symptoms is eliminated completely.Continue observation 4 d, health is good, and tetanus is cured.
Exemplary 2
Huang raises 16 years old public Babalus bubalis L., on April 8th, 2012, poultry master came to go to a doctor, main suit: very busy on the occasion of spring ploughing in the recent period, usage amount is large, except herding, also supplement concentrate, add and feed ripe Rice & peanut milk, Testa oryzae, from April 6, this cattle spirit was depressed, the sleeping ground of happiness, do not pasture, inject after 2 penicillins through village veterinary and have no improvement.This cowshed is simple and crude, and moist, do not seek shelter from wind and rain in three faces, ground cattle manure is amassed thick.Clinical examination, sick cattle lassitude, nutrition is poor, asoscope is dry, ruminates weak, body temperature 39 DEG C, breathe 28 times/min, pulse 50 times/min, rumen peristalsis 1 time/2m in, peristaltic sound is weak, palpation cud fullness degree is medium, and head and neck is slightly stiff, and abdominal part has not obvious constriction, sick cattle is led the outer hard place motion of house, walking is walked lamely, and right hind hoof performance pain, is afraid of to bear a heavy burden, gait is strong, stride is short and small, joint stuffiness, takes a step difficult, extremity appearance skin has no wound, and joint has no swelling distortion.After rinsing right hind frog cattle manure with water, to see in frog that ditch place is hindered by puncture and deeply reach 2cm, infection suppurates, diagnose on inspection, be defined as tetanus, require poultry main cleaning in time cowshed cattle manure, dry rice straw on pad, ventilation roof leaking place nail lid plank, with cold-proof heat insulation, avoids environmental stimuli.Oxidant disinfectant 3% hydrogen peroxide is selected thoroughly to clean wound, remove pus, foreign body, secretions and slough, every day with 5% iodine tincture disinfection once, gavage Chinese medicine composition soup decoct prepared by the embodiment of the present invention 1, every day 3 times, each 1 time of morning, noon and afternoon, each 500ml, through treatment in 15 days, sick cattle recovery from illness.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (2)
1. be used for the treatment of the tetanic Chinese medicine preparation of animal, it is characterized in that: crude drug is made up of Arisaema Cum Bile, the Radix Angelicae Dahuricae, Scorpio, Fructus Viticis, Ootheca Mantidis, Rhizoma Gastrodiae, Caulis Polygoni Multiflori, Cortex Acanthopancis, Ramulus Cinnamomi, Rhizoma Et Radix Notopterygii, Fructus Cnidii, Herba Centipedae, Galla Chinensis, Herba Leonuri, Herba Alternantherae sessilis, Herba Hyperici Sampsonii, the Radix Astragali, Herba pegani harmalae, Radix Talini Paniculati and Radix Glycyrrhizae;
The weight of each crude drug is respectively Arisaema Cum Bile 35g ~ 45g, Radix Angelicae Dahuricae 55g ~ 65g, Scorpio 25g ~ 35g, Fructus Viticis 35g ~ 45g, Ootheca Mantidis 25g ~ 35g, Rhizoma Gastrodiae 45g ~ 55g, Caulis Polygoni Multiflori 25g ~ 35g, Cortex Acanthopancis 45g ~ 55g, Ramulus Cinnamomi 35g ~ 45g, Rhizoma Et Radix Notopterygii 25g ~ 35g, Fructus Cnidii 65g ~ 75g, Herba Centipedae 45g ~ 55g, Galla Chinensis 35g ~ 45g, Herba Leonuri 25g ~ 35g, Herba Alternantherae sessilis 35g ~ 45g, Herba Hyperici Sampsonii 25g ~ 35g, Radix Astragali 55g ~ 65g, Herba pegani harmalae 15g ~ 25g, Radix Talini Paniculati 35g ~ 45g and Radix Glycyrrhizae 25g ~ 35g.
2. Chinese medicine preparation as claimed in claim 1, is characterized in that: the weight of each crude drug is respectively Arisaema Cum Bile 38g ~ 42g, Radix Angelicae Dahuricae 58g ~ 62g, Scorpio 28g ~ 32g, Fructus Viticis 38g ~ 42g, Ootheca Mantidis 28g ~ 32g, Rhizoma Gastrodiae 48g ~ 52g, Caulis Polygoni Multiflori 28g ~ 32g, Cortex Acanthopancis 48g ~ 52g, Ramulus Cinnamomi 38g ~ 42g, Rhizoma Et Radix Notopterygii 28g ~ 32g, Fructus Cnidii 68g ~ 72g, Herba Centipedae 48g ~ 52g, Galla Chinensis 38g ~ 42g, Herba Leonuri 28g ~ 32g, Herba Alternantherae sessilis 38g ~ 42g, Herba Hyperici Sampsonii 28g ~ 32g, Radix Astragali 58g ~ 62g, Herba pegani harmalae 18g ~ 22g, Radix Talini Paniculati 38g ~ 42g and Radix Glycyrrhizae 28g ~ 32g.
3
.chinese medicine preparation as claimed in claim 1 or 2, is characterized in that: the weight of each crude drug is respectively Arisaema Cum Bile 40g, Radix Angelicae Dahuricae 60g, Scorpio 30g, Fructus Viticis 40g, Ootheca Mantidis 30g, Rhizoma Gastrodiae 50g, Caulis Polygoni Multiflori 30g, Cortex Acanthopancis 50g, Ramulus Cinnamomi 40g, Rhizoma Et Radix Notopterygii 30g, Fructus Cnidii 70g, Herba Centipedae 50g, Galla Chinensis 40g, Herba Leonuri 30g, Herba Alternantherae sessilis 40g, Herba Hyperici Sampsonii 30g, Radix Astragali 60g, Herba pegani harmalae 20g, Radix Talini Paniculati 40g and Radix Glycyrrhizae 30g.
4
.the preparation method of Chinese medicine preparation described in claim 1 or 2, is characterized in that:
Each crude drug of described Chinese medicine preparation is uniformly mixed according to weight above, stirring the mixture of obtaining adds the soak by water 2 hours ~ 4 hours of 10 times amount, filter, filtering residue adds the soak by water 1 hour ~ 3 hours of 6 times amount again, filter, the filtrate mixing of twice, being concentrated into crude drug concentration is 1g/ml ~ 2g/ml.
5
.one is used for the treatment of the tetanic Chinese medicine preparation of animal, it is characterized in that: the crude drug of described Chinese medicine preparation is made up of Arisaema Cum Bile, the Radix Angelicae Dahuricae, Scorpio, Fructus Viticis, Ootheca Mantidis, Rhizoma Gastrodiae, Caulis Polygoni Multiflori, Cortex Acanthopancis, Ramulus Cinnamomi, Rhizoma Et Radix Notopterygii, Fructus Cnidii, Herba Centipedae, Galla Chinensis, Herba Leonuri, Herba Alternantherae sessilis, Herba Hyperici Sampsonii, the Radix Astragali, Herba pegani harmalae, Radix Talini Paniculati and Radix Glycyrrhizae;
The weight of each crude drug is respectively Arisaema Cum Bile 35g ~ 45g, Radix Angelicae Dahuricae 55g ~ 65g, Scorpio 25g ~ 35g, Fructus Viticis 35g ~ 45g, Ootheca Mantidis 25g ~ 35g, Rhizoma Gastrodiae 45g ~ 55g, Caulis Polygoni Multiflori 25g ~ 35g, Cortex Acanthopancis 45g ~ 55g, Ramulus Cinnamomi 35g ~ 45g, Rhizoma Et Radix Notopterygii 25g ~ 35g, Fructus Cnidii 65g ~ 75g, Herba Centipedae 45g ~ 55g, Galla Chinensis 35g ~ 45g, Herba Leonuri 25g ~ 35g, Herba Alternantherae sessilis 35g ~ 45g, Herba Hyperici Sampsonii 25g ~ 35g, Radix Astragali 55g ~ 65g, Herba pegani harmalae 15g ~ 25g, Radix Talini Paniculati 35g ~ 45g and Radix Glycyrrhizae 25g ~ 35g,
The preparation method of described Chinese medicine preparation is specially, the raw material of described each Chinese medicine preparation is uniformly mixed according to weight above, stirring the mixture of obtaining adds the soak by water 2 hours ~ 4 hours of 10 times amount, filter, filtering residue adds the soak by water 1 hour ~ 3 hours of 6 times amount again, filter, the filtrate mixing of twice, being concentrated into crude drug concentration is 1g/ml ~ 2g/ml.
6
.chinese medicine preparation described in claim 1, is characterized in that: described Chinese medicine preparation is decoction.
7
.chinese medicine preparation according to claim 1, is characterized in that: it is used for the treatment of the tetanus of heavy livestock.
8
.chinese medicine preparation according to claim 7, is characterized in that: described heavy livestock is horse, cattle, sheep.
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