CN103432425A - Medicinal preparation for treating tetanus of animals - Google Patents
Medicinal preparation for treating tetanus of animals Download PDFInfo
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Abstract
The invention provides a Chinese herba preparation for treating tetanus of animals. The raw material medicines of the Chinese herba preparation for treating tetanus of the animals comprise arisaema cum bile, radix angelicae, scorpion, fructus viticis, mantis egg-case, gastrodia elata, vine of multiflower knotweed, cortex acanthopanacis, cassia twig, notopterygium root, fructus cnidii, small centipeda herb, gallnut, leonurus, alternanthera nodiflora, hypericum sampsonii hance, astragalus mongholicus, peganum harmala, talinum crassifolium and liquorice. The Chinese herba preparation for treating tetanus of the animals is low in price and sufficient in raw material supply, is safe and reliable, has no side effects, has the characteristics of regulating the metabolism of an organism and balancing yin and yang, and can be used for complete regulation of nerve, body fluid and cell molecule of the organism.
Description
Technical field
The present invention relates to the Chinese medicine technical field, relate in particular to a kind of tetanic pharmaceutical preparation of animal that is used for the treatment of.
Background technology
Tetanus has another name called " Stretches ", is the acute poisoning sexually transmitted disease caused through wound infection by clostridium tetani, and the generation of primary disease must be by traumatic infection, and the material that usually due to wound infection, contains the clostridium tetani brood cell causes.This disease main manifestations Skeletal Muscle Sustained spasm and to stimulating reflex excitability to increase.Clostridium tetani claims again tetanic clostridium, is long 4～8 μ m, the elongated bacillus of wide 0.3～0.5 μ m, and how single existence, form the brood cell at thalline one end, is the drumstick shape, and all flagellums can move, without pod membrane.Gram-positive, the reaction that is negative after 48 h, anaerobism.The antigen of clostridium tetani has two kinds of somatic antigen and flagellar antigens, and somatic antigen has the genus specificity, and flagellar antigen has type specificity.This bacterium extensively is present in the feces of soil, dust, corrupt mud and Livestock, when animal generation wound, wound is little and dark or by feces, sludged blood capping, or wound has aerobe jointly to infect, tetanus brood cell is the growth promoter breeding under oxygen free condition, produce a large amount of sphaceltoxins, hemotoxin, cause the animal morbidity.
Clostridium tetani can produce toxin in the ill domestic animal body: sphaceltoxin causes ill domestic animal Skeletal Muscle Sustained spasm, increases stimulating reflex excitability, and stimulates body to produce protection antibody; Hemotoxin causes that the local organization dissolving is downright bad, for the pathogen growth breeding creates conditions.
Clostridium tetani extensively is present in soil, dust, mud and human and animal excreta, the equal susceptible of various domestic animals, and the susceptible of soliped wherein, pig, sheep, cattle take second place.Tetanic popular in seasonal, young stock is than domestic animal at advanced age susceptible more.Clostridium tetani is strict anaerobes, very fast dead after contact oxygen.
Clostridium tetani, in wound is invaded the ill domestic animal organizer, breeds and produces toxin in a large number, thereby causing morbidity in anaerobism, acid wound environment.Tetanopasmin is up to the cornu ventrale medullae spinalis neurocyte by the space between peripheral nerve fiber, or arrive the nervus motorius maincenter by lymph, blood, especially the ganglioside in neural with brain stem and ventricornu neurocyte forms irreversible combination, sealing spinal cord inhibitory synapse, prevent the transmission of the normal inhibiting impulse between upper and lower neuron, result causes reflex excitability to increase and the lasting spastic contraction of muscle.Respiratory function is upset, and then circulatory disturbance and hemodynamic upset occur, and dehydration, acidosis occur.
The tetanic method of traditional treatment is injection tetanus toxoid antigen, heavy dose of blood sampling of heavy dose often, makes animal liver cell that degeneration necrosis occur gradually, and the liver enlargement degeneration, become " Glycine max (L.) Merr. " sample, and last liver edge is broken, and activates thing death.
Holy Benevolent Prescriptions is said: " orthotonus, locked mouth can not be opened, and extremity tremble, diaphysis pain, the appearance convulsion is oblique, and this all damages in part in ailment said due to cold or exposure, therefore named tetanus.Its pathogenesis is that exopathogen is stopped up stagnant meridians, the four stages in the course of an epidemic febrile disease impatency is not transported, and the priming liver-wind is controlled when dispeling the wind removing toxic substances, activating blood and promoting diuresis, relieving spasm for resuscitation, the present invention is exactly under the support of theory of Chinese medical science, a kind of tetanic Chinese medicine preparation of animal that is used for the treatment of of proposition, this Chinese medicine preparation price is low, the source of goods is wide, safe and reliable, have no side effect, it is to adjust organism metabolism, and Yin Yang balancing is characteristics, can carry out comprehensive adjusting to nerve, body fluid and the group extracellular molecule of body.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of tetanic Chinese medicine preparation of animal that is used for the treatment of, its price is low, the source of goods is wide, safe and reliable, have no side effect, to adjust organism metabolism, Yin Yang balancing is characteristics, can carry out comprehensive adjusting to nerve, body fluid and the group extracellular molecule of body.
For solving the problems of the technologies described above, the invention provides a kind of tetanic Chinese medicine preparation of animal that is used for the treatment of, its crude drug comprises: Arisaema Cum Bile, the Radix Angelicae Dahuricae, Scorpio, Fructus Viticis, Ootheca Mantidis, Rhizoma Gastrodiae, Caulis Polygoni Multiflori, Cortex Acanthopancis, Ramulus Cinnamomi, Rhizoma Et Radix Notopterygii, Fructus Cnidii, Herba Centipedae, Galla Chinensis, Herba Leonuri, Herba Alternantherae sessilis, Herba Hyperici Sampsonii, the Radix Astragali, Herba pegani harmalae, Radix Talini Paniculati and Radix Glycyrrhizae.
In described Chinese medicine preparation, the weight of each crude drug is respectively Arisaema Cum Bile 35g ~ 45g, Radix Angelicae Dahuricae 55g ~ 65g, Scorpio 25g ~ 35g, Fructus Viticis 35g ~ 45g, Ootheca Mantidis 25g ~ 35g, Rhizoma Gastrodiae 45g ~ 55g, Caulis Polygoni Multiflori 25g ~ 35g, Cortex Acanthopancis 45g ~ 55g, Ramulus Cinnamomi 35g ~ 45g, Rhizoma Et Radix Notopterygii 25g ~ 35g, Fructus Cnidii 65g ~ 75g, Herba Centipedae 45g ~ 55g, Galla Chinensis 35g ~ 45g, Herba Leonuri 25g ~ 35g, Herba Alternantherae sessilis 35g ~ 45g, Herba Hyperici Sampsonii 25g ~ 35g, Radix Astragali 55g ~ 65g, Herba pegani harmalae 15g ~ 25g, Radix Talini Paniculati 35g ~ 45g and Radix Glycyrrhizae 25g ~ 35g.
In described Chinese medicine preparation, the weight of each raw material further preferably is respectively Arisaema Cum Bile 38g ~ 42g, Radix Angelicae Dahuricae 58g ~ 62g, Scorpio 28g ~ 32g, Fructus Viticis 38g ~ 42g, Ootheca Mantidis 28g ~ 32g, Rhizoma Gastrodiae 48g ~ 52g, Caulis Polygoni Multiflori 28g ~ 32g, Cortex Acanthopancis 48g ~ 52g, Ramulus Cinnamomi 38g ~ 42g, Rhizoma Et Radix Notopterygii 28g ~ 32g, Fructus Cnidii 68g ~ 72g, Herba Centipedae 48g ~ 52g, Galla Chinensis 38g ~ 42g, Herba Leonuri 28g ~ 32g, Herba Alternantherae sessilis 38g ~ 42g, Herba Hyperici Sampsonii 28g ~ 32g, Radix Astragali 58g ~ 62g, Herba pegani harmalae 18g ~ 22g, Radix Talini Paniculati 38g ~ 42g and Radix Glycyrrhizae 28g ~ 32g.
In described Chinese medicine preparation, the weight of each raw material further preferably is respectively Arisaema Cum Bile 40g, Radix Angelicae Dahuricae 60g, Scorpio 30g, Fructus Viticis 40g, Ootheca Mantidis 30g, Rhizoma Gastrodiae 50g, Caulis Polygoni Multiflori 30g, Cortex Acanthopancis 50g, Ramulus Cinnamomi 40g, Rhizoma Et Radix Notopterygii 30g, Fructus Cnidii 70g, Herba Centipedae 50g, Galla Chinensis 40g, Herba Leonuri 30g, Herba Alternantherae sessilis 40g, Herba Hyperici Sampsonii 30g, Radix Astragali 60g, Herba pegani harmalae 20g, Radix Talini Paniculati 40g and Radix Glycyrrhizae 30g.
The present invention also provides the preparation method of above-mentioned Chinese medicine preparation, is specially:
The raw material of described each Chinese medicine preparation is uniformly mixed according to top weight, and the decocting that adds 10 times of amounts that stirs the mixture of acquisition boils 2 hours ~ 4 hours, filters, the decocting that filtering residue adds 6 times of amounts again boils 1 hour ~ 3 hours, filter, the filtrate of twice is mixed, and being concentrated into crude drug concentration is 1g/ml ~ 2g/ml.
The present invention also provides a kind of tetanic Chinese medicine preparation of animal that is used for the treatment of, and its crude drug comprises: Arisaema Cum Bile, the Radix Angelicae Dahuricae, Scorpio, Fructus Viticis, Ootheca Mantidis, Rhizoma Gastrodiae, Caulis Polygoni Multiflori, Cortex Acanthopancis, Ramulus Cinnamomi, Rhizoma Et Radix Notopterygii, Fructus Cnidii, Herba Centipedae, Galla Chinensis, Herba Leonuri, Herba Alternantherae sessilis, Herba Hyperici Sampsonii, the Radix Astragali, Herba pegani harmalae, Radix Talini Paniculati and Radix Glycyrrhizae;
The preparation method of described Chinese medicine preparation is specially, the raw material of described each Chinese medicine preparation is uniformly mixed according to top weight, the decocting that adds 10 times of amounts that stirs the mixture obtained boils 2 hours ~ 4 hours, filter, the decocting that filtering residue adds 6 times of amounts again boils 1 hour ~ 3 hours, filter, the filtrate of twice is mixed, and being concentrated into crude drug concentration is 1g/ml ~ 2g/ml.
Chinese medicine preparation provided by the invention is the soup decoct.
Chinese medicine preparation provided by the invention is used for the treatment of the tetanus of heavy livestock.
Described heavy livestock is horse, cattle, sheep.
Beneficial effect of the present invention:
The tetanic Chinese medicine preparation of animal that is used for the treatment of provided by the invention, its price is low, the source of goods is wide, safe and reliable, have no side effect, to adjust organism metabolism, Yin Yang balancing is characteristics, can carry out comprehensive adjusting to nerve, body fluid and the group extracellular molecule of body.
The specific embodiment
Holy Benevolent Prescriptions is said: " orthotonus, locked mouth can not be opened, and extremity tremble, diaphysis pain, the appearance convulsion is oblique, and this all damages in part in ailment said due to cold or exposure, therefore named tetanus.Chinese veterinarian thinks, tetanus is pathogenic factor through the wound intrusion space between skin and muscles of taking advantage of a loophole, and good and evil are fought mutually, healthy energy must not defend and declared logical, muscle arteries and veins to lose and support and contracture by strongly fragrant, battalion, and the heresy of pathogenic wind toxic that continues is fled meridians, the enemy intrusion or invasion is in liver priming liver-wind, thus occur that muscle spasm is arrested by force, the symptom such as gnathospasma, extremity are stiff.The rule for the treatment of is relieving convulsion for dispeling the wind, the removing toxic substances relieving convulsion.
A kind of tetanic Chinese medicine preparation of animal that is used for the treatment of, its crude drug comprises: Arisaema Cum Bile, the Radix Angelicae Dahuricae, Scorpio, Fructus Viticis, Ootheca Mantidis, Rhizoma Gastrodiae, Caulis Polygoni Multiflori, Cortex Acanthopancis, Ramulus Cinnamomi, Rhizoma Et Radix Notopterygii, Fructus Cnidii, Herba Centipedae, Galla Chinensis, Herba Leonuri, Herba Alternantherae sessilis, Herba Hyperici Sampsonii, the Radix Astragali, Herba pegani harmalae, Radix Talini Paniculati and Radix Glycyrrhizae.
In described Chinese medicine preparation, the weight of each crude drug is respectively Arisaema Cum Bile 35g ~ 45g, Radix Angelicae Dahuricae 55g ~ 65g, Scorpio 25g ~ 35g, Fructus Viticis 35g ~ 45g, Ootheca Mantidis 25g ~ 35g, Rhizoma Gastrodiae 45g ~ 55g, Caulis Polygoni Multiflori 25g ~ 35g, Cortex Acanthopancis 45g ~ 55g, Ramulus Cinnamomi 35g ~ 45g, Rhizoma Et Radix Notopterygii 25g ~ 35g, Fructus Cnidii 65g ~ 75g, Herba Centipedae 45g ~ 55g, Galla Chinensis 35g ~ 45g, Herba Leonuri 25g ~ 35g, Herba Alternantherae sessilis 35g ~ 45g, Herba Hyperici Sampsonii 25g ~ 35g, Radix Astragali 55g ~ 65g, Herba pegani harmalae 15g ~ 25g, Radix Talini Paniculati 35g ~ 45g and Radix Glycyrrhizae 25g ~ 35g.
In described Chinese medicine preparation, the weight of each raw material further preferably is respectively Arisaema Cum Bile 38g ~ 42g, Radix Angelicae Dahuricae 58g ~ 62g, Scorpio 28g ~ 32g, Fructus Viticis 38g ~ 42g, Ootheca Mantidis 28g ~ 32g, Rhizoma Gastrodiae 48g ~ 52g, Caulis Polygoni Multiflori 28g ~ 32g, Cortex Acanthopancis 48g ~ 52g, Ramulus Cinnamomi 38g ~ 42g, Rhizoma Et Radix Notopterygii 28g ~ 32g, Fructus Cnidii 68g ~ 72g, Herba Centipedae 48g ~ 52g, Galla Chinensis 38g ~ 42g, Herba Leonuri 28g ~ 32g, Herba Alternantherae sessilis 38g ~ 42g, Herba Hyperici Sampsonii 28g ~ 32g, Radix Astragali 58g ~ 62g, Herba pegani harmalae 18g ~ 22g, Radix Talini Paniculati 38g ~ 42g and Radix Glycyrrhizae 28g ~ 32g.
In described Chinese medicine preparation, the weight of each raw material further preferably is respectively Arisaema Cum Bile 40g, Radix Angelicae Dahuricae 60g, Scorpio 30g, Fructus Viticis 40g, Ootheca Mantidis 30g, Rhizoma Gastrodiae 50g, Caulis Polygoni Multiflori 30g, Cortex Acanthopancis 50g, Ramulus Cinnamomi 40g, Rhizoma Et Radix Notopterygii 30g, Fructus Cnidii 70g, Herba Centipedae 50g, Galla Chinensis 40g, Herba Leonuri 30g, Herba Alternantherae sessilis 40g, Herba Hyperici Sampsonii 30g, Radix Astragali 60g, Herba pegani harmalae 20g, Radix Talini Paniculati 40g and Radix Glycyrrhizae 30g.
Each raw material pharmacology is:
Arisaema Cum Bile: bitter in the mouth, micro-suffering, cool in nature, return lung, liver, spleen channel, there is removing heat-phlegm, the effect of dispelling wind and relieving convulsion, for phlegm-heat cough, cough up phlegm yellow thick, middle wind-phlegm fan, the cards such as demented infantile convulsion.
The Radix Angelicae Dahuricae: warm in nature, acrid in the mouth, return lung, spleen, stomach warp, has the cold expelling of inducing sweat, wind-expelling pain-stopping, clearing the nasal passage, the dampness leukorrhagia stopping, the effect of detumescence and apocenosis, cure mainly headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, the cards such as scabies.
Scorpio: acrid in the mouth, property is flat, returns Liver Channel, has endogenous wind stopping spasmolytic, dispersing pathogen accumulation, the effect of removing obstruction in the collateral to relieve pain, cure mainly infantile convulsion, the tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, the cards such as scrofula.
Fructus Viticis: acrid in the mouth, hardship, cold nature, return bladder, liver, stomach warp, has dispelling wind and heat pathogens, and the clear sharp head's effect cures mainly anemopyretic cold headache, gingivitis, the many tear of conjunctival congestion, poor vision, the card such as have a dizzy spell.
Ootheca Mantidis: latin name
ootheca Mantidis, salty sweet, flat, return liver, kidney, urinary bladder channel, there is the kidney invigorating, astringent or styptic treatment for spontaneous sweating, the effect of only losing, cure mainly the cards such as bed-wetting, frequent urination at night, seminal emission premature ejaculation, sexual impotence of insufficiency of kidney-YANG, and not only tonification but also astringent therapy, be the good medicine of reinforcing the kidney and supporting YANG, controlling nocturnal emission with astringent drugs reducing urination.Emission and spermatorrhea, the enuresis, frequent micturition, sexual impotence due to all kidney yang deficiencies, vital essence mistake admittedly are sterile, all can select the especially suitable enuresis, frequent micturition.
Rhizoma Gastrodiae: sweet in the mouth, property are flat, enter Liver Channel, and suppressing the hyperactive liver to relieve the wind syndrome is arranged, spasmolytic, and the effect of removing obstruction in the collateral to relieve pain, be mainly used in the dizzy headache of flaming up of liver-fire, the cards such as the strong wind tic due to excessive rising of liver-YANG, liver-wind stirring up internally, epilepsy.
Caulis Polygoni Multiflori: sweet in the mouth, property is flat, and GUIXIN, Liver Channel, have nourishing blood to tranquillize the mind, and the effect of dispelling wind and removing obstruction in the collateral, cure mainly insomnia and dreamful sleep, blood deficiency general pain, rheumatic arthralgia; The cards such as skin pruritus, Caulis Polygoni Multiflori can be invigorated blood circulation, stimulated the menstrual flow, blood vessel dilating, blood circulation promoting, stimulating milk secretion detumescence.
Cortex Acanthopancis: acrid in the mouth, hardship, micro-sweet, warm in nature, enter liver, kidney channel, there is wind-damp dispelling, invigorating the liver and kidney, the effect of bone and muscle strengthening, be mainly used in rheumatism and arthritis, and the muscles and bones flaccidity is soft, traumatic injury, fracture, edema, the fragile card that waits.
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature, GUIXIN, lung, urinary bladder channel, have the diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, the effect of dispersing cold for relieving pain, the Ramulus Cinnamomi warming the meridian and promoting blood circulation, horizontal logical podomere, for the affection of exogenous wind-cold exterior syndrome, no matter antiperspirant is arranged, losslessly all can apply, also for rheumatic arthralgia, cold syndrome of the stomach stomachache, amenorrhea, dysmenorrhea, rheumatic arthralgia, the cards such as shoulder arm podomere cold type of pain, phlegm retention syndrome and bladder water-retention, heart deficiency of spleen-YANG, retention of water-damp in the body, fullness and distention in the chest and hypochondrium, the dizzy phlegm retention syndrome that waits of cough with dyspnea.
Rhizoma Et Radix Notopterygii: latin name
notopterygii Rhizoma et Radix,acrid in the mouth, hardship, warm in nature, enter kidney, urinary bladder channel, there is the effect of the cold expelling that induces sweat, expelling wind and dampness, pain relieving, there is the wet exterior syndrome of wind and cold folder, disease is seen fever with aversion to cold, headache as is wrapped up in, neck rigid back pain, limbs are heavy, and joint is ached, the cards such as anemofrigid-damp arthralgia.
Fructus Cnidii: latin name
cnidii Fructus, acrid in the mouth, hardship, warm in nature, enter kidney channel, there is the effect of warming the kidney to invigorate YANG, removing dampness and killing parasites, dispelling wind for relieving itching, the impotence in male caused for kidney yang deficiency, woman's cold womb are infertile, the cards such as cold-damp leukorrhagia or chills and pain of the waist and kness.
Herba Centipedae: latin name
centipedae Hebra,acrid in the mouth, warm in nature, enter lung, Liver Channel, there is cold-dispelling, clearing the nasal passage, eliminating phlegm and stopping cough, the effect of dissipating blood stasis for subsidence of swelling, for exterior syndrome due to wind-cold, nasal obstruction watery nasal discharge and nasal sinusitis, cough with copious phlegm, pertussis, the cards such as sore, carbuncle and painful swelling.
Galla Chinensis: latin name
galla Chinensis,sour in the mouth, puckery, cold in nature, return lung, large intestine, kidney channel, there is the effect of astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of convergence, kidney calming, cure mainly: chronic cough of deficiency lung; Spontaneous sweating; The chronic dysentery chronic diarrhea; Proctoptosis; Seminal emission; Nebulousurine; Various hemorrhage; The cards such as carbuncle furuncle.
Herba Leonuri: latin name
leonuri Herba, bitter in the mouth, suffering, cold nature, enter liver, pericardium channel, has promoting blood flow to regulate menstruation, and the effect of inducing diuresis to remove edema, cure mainly menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria, the cards such as acute nephritis edema.
Herba Alternantherae sessilis: sweet in the mouth, cold in nature, there is cool the blood dissipate blood stasis, heat-clearing and toxic substances removing, the treating stranguria card that waits that dehumidifies, cure mainly hemoptysis, spits blood, have blood in stool, jaundice due to damp-heat, dysentery, have loose bowels, gingival swelling and pain, laryngopharynx swelling and pain, acute mastitis, swollen ulcer drug, traumatic injury, the cards such as venom.
Herba Hyperici Sampsonii: bitter in the mouth, suffering, cold in nature, return liver, spleen channel, there is removing pathogenic heat from blood and toxic substance from the body, promoting blood flow to regulate menstruation, the effect of dispelling wind and removing obstruction in the collateral, cure mainly various hemorrhage, enteritis and dysentery, acute mastitis, the carbuncle furunculosis, scald, venom, menoxenia, dysmenorrhea, leucorrhea, traumatic injury, rheumatic arthralgia, the cards such as aphtha.
The Radix Astragali: sweet in the mouth, warm in nature, enter spleen, lung meridian, the benefit strengthening spleen and lung is arranged, elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, the effects such as holder skin ulcer granulation promoting, be mainly used in the weak anorexia and loose stool due to deficiency of both the splenic and pulmonary QI, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, the chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency, the cards such as insufficiency of vital energy and blood.
Herba pegani harmalae: acrid in the mouth, hardship; Property is put down, and has relieving cough and asthma; Wind-damp dispelling; The malicious effect of subsiding a swelling.Cure mainly cough and asthma; Rheumatic arthralgia; Innominate toxic swelling; The cards such as skin pruritus.
Radix Talini Paniculati: latin name
pedicularis muscicola Maxim, sweet in the mouth, micro-hardship, the tool heat-clearing toxin-expelling functions, weak to the deficiency of vital energy, diarrhea due to hypofunction of the spleen, the xeropulmonary cough, neurasthenias etc. have certain curative effect.Strongly invigorating primordial QI, promoting the production of body fluid and inducing sedation of the mind, heart tonifying.Control QI and blood deficient, asthenia hyperhidrosis, collapse exhaustion, Blood pressure drop.
Radix Glycyrrhizae: latin name
glycyrrhizae Radix et Rhizoma, sweet in the mouth, property is flat, enters 12 warps, and heat-clearing and toxic substances removing is arranged, and is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, be mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak; Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, by adding Radix Glycyrrhizae, can play the QI invigorating neutralization, is in harmonious proportion the work of each component.
The present invention also provides the preparation method of above-mentioned Chinese medicine preparation, is specially:
The raw material of described each Chinese medicine preparation is uniformly mixed according to top weight, the decocting that adds 10 times of amounts that stirs the mixture obtained boils 2 hours ~ 4 hours, filter, the decocting that filtering residue adds again with respect to 6 times of amounts of mixture quality boils 1 hour ~ 3 hours, filter, the filtrate of twice is mixed, and being concentrated into crude drug concentration is 1g/ml ~ 2g/ml.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how the application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine preparation 1
Arisaema Cum Bile 40g, Radix Angelicae Dahuricae 60g, Scorpio 30g, Fructus Viticis 40g, Ootheca Mantidis 30g, Rhizoma Gastrodiae 50g, Caulis Polygoni Multiflori 30g, Cortex Acanthopancis 50g, Ramulus Cinnamomi 40g, Rhizoma Et Radix Notopterygii 30g, Fructus Cnidii 70g, Herba Centipedae 50g, Galla Chinensis 40g, Herba Leonuri 30g, Herba Alternantherae sessilis 40g, Herba Hyperici Sampsonii 30g, Radix Astragali 60g, Herba pegani harmalae 20g, Radix Talini Paniculati 40g and Radix Glycyrrhizae 30g are uniformly mixed, the decocting that adds 8kg that stirs the mixture obtained boils 4 hours, filter, the decocting that filtering residue adds 6kg again boils 3 hours, filter, the filtrate of twice is mixed, and being concentrated into crude drug concentration is 1g/ml.
Embodiment 2 Chinese medicine preparation 2
Arisaema Cum Bile 38g, Radix Angelicae Dahuricae 58g, Scorpio 28g, Fructus Viticis 38g, Ootheca Mantidis 28g, Rhizoma Gastrodiae 48g, Caulis Polygoni Multiflori 28g, Cortex Acanthopancis 48g, Ramulus Cinnamomi 38g, Rhizoma Et Radix Notopterygii 28g, Fructus Cnidii 68g, Herba Centipedae 48g, Galla Chinensis 38g, Herba Leonuri 28g, Herba Alternantherae sessilis 38g, Herba Hyperici Sampsonii 28g, Radix Astragali 58g, Herba pegani harmalae 18g, Radix Talini Paniculati 38g and Radix Glycyrrhizae 28g are uniformly mixed, the decocting that adds 8kg that stirs the mixture obtained boils 4 hours, filter, the decocting that filtering residue adds 6kg again boils 3 hours, filter, the filtrate of twice is mixed, and being concentrated into crude drug concentration is 2g/ml.
Embodiment 3 Chinese medicine preparation 3
Arisaema Cum Bile 42g, Radix Angelicae Dahuricae 62g, Scorpio 32g, Fructus Viticis 42g, Ootheca Mantidis 32g, Rhizoma Gastrodiae 52g, Caulis Polygoni Multiflori 32g, Cortex Acanthopancis 52g, Ramulus Cinnamomi 42g, Rhizoma Et Radix Notopterygii 32g, Fructus Cnidii 72g, Herba Centipedae 52g, Galla Chinensis 42g, Herba Leonuri 32g, Herba Alternantherae sessilis 42g, Herba Hyperici Sampsonii 32g, Radix Astragali 62g, Herba pegani harmalae 22g, Radix Talini Paniculati 42g and Radix Glycyrrhizae 32g are uniformly mixed, the decocting that adds 8kg that stirs the mixture obtained boils 4 hours, filter, the decocting that filtering residue adds 6kg again boils 3 hours, filter, the filtrate of twice is mixed, and being concentrated into crude drug concentration is 1g/ml.
Animal experiment study
Laboratory animal: regular grade Kunming kind white mice, after laboratory is fed 1 week, average weight 29. 0g.
Experimental drug: the Chinese medicinal decoction decoct of the embodiment of the present invention 1 preparation.
Experimental technique
The foundation of tetanus animal model: (1) separates clostridium tetani from earth, after purifying, is inoculated into anaerobism in cooked meat medium and cultivates 15d, after getting the supernatant bacteriological filtration, obtains tetanopasmin, and refrigerator freezing is preserved, standby.(2) 90 white mice are divided into to 3 groups at random with SPSS11. 0 statistical software, 30 every group.Give 1 group of experiment and experiment 2 groups of Chinese medicines (0.5ml) gavage, then respectively at after 50min and 120min, left hind root intramuscular injection tetanopasmin, dosage is [Mouse Weight (g)/100+0. 06] ml.Left hind root intramuscular injection tetanopasmin after matched group (B group) normal saline (0. 5ml) gavage 50min, dosage is the same.
Observed and recorded: according to the observation index made in advance, carry out observed and recorded.Observation index has 48h mortality rate, final mortality rate (the 5th day mice to experiment is only dead without continuing), injection toxin 2 disease times, morbidity persistent period, spasm intensity [being divided into four grades: without obvious spasm (-), slight spasm (+), moderate spasm (++), strong spasm (+++)].For fear of the difference of observer's record, before experiment, the observer is unified to training, use unified conventional letter, and use unified symptom intensity record index.
Date processing: data statistics is used statistic software SPSS 11. 0 to carry out X 2 test and t check, and judged result has not statistically significant.
Result
Each organizes the death condition statistics, the results are shown in Table 1.
Table 1 is respectively organized the death condition statistics
| Group | Sum | The 48h death toll | 48h mortality rate (%) | Final death toll | Final mortality rate (%) |
| Test 1 group | 30 | 3 | 10 | 8 | 26.7 |
| Test 2 groups | 30 | 5 | 16.7 | 10 | 33.3 |
| Matched group B | 30 | 16 | 53.3 | 28 | 93.3 |
Each organizes the spasm intensity statistics, the results are shown in Table 2.
Table 2 is respectively organized the spasm intensity statistics
| Group | Sum | - | + | ++ | +++ |
| Test 1 group | 30 | 13 | 9 | 5 | 4 |
| Test 2 groups | 30 | 12 | 10 | 3 | 5 |
| Matched group B | 30 | 6 | 5 | 7 | 12 |
Each group injection toxin-disease time, morbidity persistent period statistics, the results are shown in Table 3.
Each group injection toxin-disease time of table 3, morbidity persistent period statistics
| Group | Injection toxin-disease time (min) | The morbidity persistent period (min) |
| Test 1 group | 23.1 +5.2 | 26.3 +4.9 |
| Test 2 groups | 20.9 +5.7 | 29.3 +6.2 |
| Matched group B | 13.7 +3.3 | 36.2 +3.9 |
Table 1 shows, test group is compared with matched group, on 48h mortality rate and final mortality rate, obvious minimizing is all arranged, test group mice spasm intensity is less than matched group, injection toxin-disease time is longer than matched group, and morbidity persistent period phrase matched group, illustrate that this Chinese medicine can reduce the tetanic mortality rate of white mice, obviously improve the intensity of white mice tetanus morbidity and delay disease time, and can shorten the morbidity persistent period.
Exemplary 1
On May 27th, 2010, a mare of Zhang family, red, eight years old age, be in foal four months, because being subject to the ailment said due to cold or exposure invasion and attack, the scapular region wound causes tetanus, select oxidant disinfectant 3% hydrogen peroxide thoroughly to clean wound, remove pus, foreign body, secretions and slough, every day with 5% iodine tincture disinfection once, through treatment three days, lose curative effect with crossing tetanus antitoxin 800,000 units, clinical symptoms, 38.5 ℃ of body temperature, breathing 30/minute, pulse 50 times/minutes, gnathospasma, can hold two fingers, the short time spasm appears occasionally, item neck rigidity back of the body waist is stiff, though tail is hard, end is straight rises, the walking extremity are nonvoluntary, more stiff, seeing the object eye suddenly shows money or valuables one carries unintentionally, the accentuation of cardiac sound, pulse condition is tightly counted, colour of the tongue is crimson, oral cavity stream has sticky saliva, can not chew forage, the drinking-water dysphagia, gastrointestinal pitch youth, in every day with 5% iodine tincture disinfection on basis once, the Chinese medicine composition soup decoct of using the embodiment of the present invention 1 preparation instead is gavaged, 2 doses of every days, sooner or later each 1 dose, each 500ml, strengthen feeding and management, to suffer from horse raises in peace and quiet separately, light is darker, spacious, do not have in the stable of foreign material, avoid various environmental stimulis as far as possible.For avoiding traumatic injury, get stance and help and be fixed in 6 post hurdles with suspender belt; The 2nd afternoon, suffer from horse opening successor by its grass that searches for food.Added Sal and malt sugar medicated porridge to trouble horse polydipsia.Regularly walk a horse every day, increases motion, promotes muscle function to recover, but unsuitable tired.
Ill horse is at the 2nd day opening drinking-water for the treatment of; Within the 3rd day, spasm is eliminated, and symptom obviously alleviates; To the 7th day General Symptoms, substantially eliminate.Continue medication 4 d, General Symptoms is eliminated fully.Continue to observe 4 d, health is good, and tetanus is cured.
Exemplary 2
Huang raises 16 years old public Babalus bubalis L., on April 8th, 2012, the poultry master came to go to a doctor, the main suit: very busy on the occasion of spring ploughing in the recent period, the usage amount is large, except herding, also supplement concentrate, add and feed ripe Rice & peanut milk, Testa oryzae, from April 6, this cattle spirit was depressed, the sleeping ground of happiness, the ，Jing village veterinary that do not pasture has no improvement after injecting 2 penicillins.This cowshed is simple and crude, humidity, and three faces are not sought shelter from wind and rain, and ground cattle manure is long-pending thick.Clinical examination, sick cattle lassitude, nutrition is poor, the asoscope drying, ruminate weak, 39 ℃ of body temperature, breathe 28 times/min, 50 times/min of pulse, 1 time/2m of rumen peristalsis in, a little less than peristaltic sound, palpation cud fullness degree is medium, and head and neck is slightly stiff, and abdominal part has not obvious constriction, sick cattle is led to the outer hard place motion of house, walking is walked lamely, and right hind hoof performance pain, be afraid of to bear a heavy burden, gait is strong, stride is short and small, and joint stuffiness is taken a step difficult, extremity appearance skin has no wound, and joint has no the swelling distortion.Water is shown in that in frog, the ditch place is stabbed and deeply reaches 2cm by thorn, infection suppurates after rinsing right hind frog cattle manure, diagnosis, be defined as tetanus on inspection, requires the main cleaning in time of poultry cowshed cattle manure, dry rice straw on pad, ventilation roof leaking place nail covers plank with cold-proof heat insulation, avoids environmental stimuli.Select oxidant disinfectant 3% hydrogen peroxide thoroughly to clean wound, remove pus, foreign body, secretions and slough, every day with 5% iodine tincture disinfection once, gavage the Chinese medicine composition soup decoct of the embodiment of the present invention 1 preparation, every day 3 times, morning, noon and afternoon each 1 time, each 500ml, through treatment in 15 days, sick cattle recovery from illness.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. one kind is used for the treatment of the tetanic Chinese medicine preparation of animal, and it is characterized in that: crude drug comprises Arisaema Cum Bile, the Radix Angelicae Dahuricae, Scorpio, Fructus Viticis, Ootheca Mantidis, Rhizoma Gastrodiae, Caulis Polygoni Multiflori, Cortex Acanthopancis, Ramulus Cinnamomi, Rhizoma Et Radix Notopterygii, Fructus Cnidii, Herba Centipedae, Galla Chinensis, Herba Leonuri, Herba Alternantherae sessilis, Herba Hyperici Sampsonii, the Radix Astragali, Herba pegani harmalae, Radix Talini Paniculati and Radix Glycyrrhizae.
2. Chinese medicine preparation as claimed in claim 1, it is characterized in that: the weight of each crude drug is respectively Arisaema Cum Bile 35g ~ 45g, Radix Angelicae Dahuricae 55g ~ 65g, Scorpio 25g ~ 35g, Fructus Viticis 35g ~ 45g, Ootheca Mantidis 25g ~ 35g, Rhizoma Gastrodiae 45g ~ 55g, Caulis Polygoni Multiflori 25g ~ 35g, Cortex Acanthopancis 45g ~ 55g, Ramulus Cinnamomi 35g ~ 45g, Rhizoma Et Radix Notopterygii 25g ~ 35g, Fructus Cnidii 65g ~ 75g, Herba Centipedae 45g ~ 55g, Galla Chinensis 35g ~ 45g, Herba Leonuri 25g ~ 35g, Herba Alternantherae sessilis 35g ~ 45g, Herba Hyperici Sampsonii 25g ~ 35g, Radix Astragali 55g ~ 65g, Herba pegani harmalae 15g ~ 25g, Radix Talini Paniculati 35g ~ 45g and Radix Glycyrrhizae 25g ~ 35g.
3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that: the weight of each raw material is respectively Arisaema Cum Bile 38g ~ 42g, Radix Angelicae Dahuricae 58g ~ 62g, Scorpio 28g ~ 32g, Fructus Viticis 38g ~ 42g, Ootheca Mantidis 28g ~ 32g, Rhizoma Gastrodiae 48g ~ 52g, Caulis Polygoni Multiflori 28g ~ 32g, Cortex Acanthopancis 48g ~ 52g, Ramulus Cinnamomi 38g ~ 42g, Rhizoma Et Radix Notopterygii 28g ~ 32g, Fructus Cnidii 68g ~ 72g, Herba Centipedae 48g ~ 52g, Galla Chinensis 38g ~ 42g, Herba Leonuri 28g ~ 32g, Herba Alternantherae sessilis 38g ~ 42g, Herba Hyperici Sampsonii 28g ~ 32g, Radix Astragali 58g ~ 62g, Herba pegani harmalae 18g ~ 22g, Radix Talini Paniculati 38g ~ 42g and Radix Glycyrrhizae 28g ~ 32g.
4. Chinese medicine preparation as described as claims 1 to 3, it is characterized in that: the weight of each raw material is respectively Arisaema Cum Bile 40g, Radix Angelicae Dahuricae 60g, Scorpio 30g, Fructus Viticis 40g, Ootheca Mantidis 30g, Rhizoma Gastrodiae 50g, Caulis Polygoni Multiflori 30g, Cortex Acanthopancis 50g, Ramulus Cinnamomi 40g, Rhizoma Et Radix Notopterygii 30g, Fructus Cnidii 70g, Herba Centipedae 50g, Galla Chinensis 40g, Herba Leonuri 30g, Herba Alternantherae sessilis 40g, Herba Hyperici Sampsonii 30g, Radix Astragali 60g, Herba pegani harmalae 20g, Radix Talini Paniculati 40g and Radix Glycyrrhizae 30g.
5. right Austria asks the preparation method of 1 to 4 described Chinese medicine preparation, it is characterized in that:
The raw material of described each Chinese medicine preparation is uniformly mixed according to top weight, and the decocting that adds 10 times of amounts that stirs the mixture of acquisition boils 2 hours ~ 4 hours, filters, the decocting that filtering residue adds 6 times of amounts again boils 1 hour ~ 3 hours, filter, the filtrate of twice is mixed, and being concentrated into crude drug concentration is 1g/ml ~ 2g/ml.
6. one kind is used for the treatment of the tetanic Chinese medicine preparation of animal, and it is characterized in that: the crude drug of described Chinese medicine preparation comprises Arisaema Cum Bile, the Radix Angelicae Dahuricae, Scorpio, Fructus Viticis, Ootheca Mantidis, Rhizoma Gastrodiae, Caulis Polygoni Multiflori, Cortex Acanthopancis, Ramulus Cinnamomi, Rhizoma Et Radix Notopterygii, Fructus Cnidii, Herba Centipedae, Galla Chinensis, Herba Leonuri, Herba Alternantherae sessilis, Herba Hyperici Sampsonii, the Radix Astragali, Herba pegani harmalae, Radix Talini Paniculati and Radix Glycyrrhizae;
The preparation method of described Chinese medicine preparation is specially, the raw material of described each Chinese medicine preparation is uniformly mixed according to top weight, the decocting that adds 10 times of amounts that stirs the mixture obtained boils 2 hours ~ 4 hours, filter, the decocting that filtering residue adds again with respect to 6 times of amounts of mixture quality boils 1 hour ~ 3 hours, filter, the filtrate of twice is mixed, and being concentrated into crude drug concentration is 1g/ml ~ 2g/ml.
7. the described Chinese medicine preparation of claim 1 to 6, it is characterized in that: described Chinese medicine preparation is the soup decoct.
8. the described Chinese medicine preparation of claim 1 to 7, it is characterized in that: it is used for the treatment of the tetanus of heavy livestock.
9. Chinese medicine preparation claimed in claim 8, it is characterized in that: described heavy livestock is horse, cattle, sheep.
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| CN107126507A (en) * | 2017-05-19 | 2017-09-05 | 佛山市高明区生产力促进中心 | A kind of Chinese herbal medicine for being used to treat live pig Tetanus |
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