CN103721045B - For improving the Chinese traditional immunopoteniators of broiler immunologic function in growth course - Google Patents
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Abstract
The invention provides a kind of Chinese traditional immunopoteniators for improving broiler immunologic function in growth course, its crude drug includes Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Radix Platycodonis, Radix Phytolaccae, Fructus Psoraleae, Fructus Crataegi, Rhizoma Dioscoreae, Flos Lonicerae, Caulis Sargentodoxae, Fructus Cnidii, Herba Artemisiae Annuae, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Rhizoma Polygonati, Fructus Lycii, Radix Glehniae, Radix Angelicae Sinensis, Radix Isatidis, Herba Visci, Radix Polygoni Multiflori, Caulis Fibraureae, Xi, Herb Gynostemmae Pentaphylli and Radix Glycyrrhizae.The Chinese traditional immunopoteniators that the present invention provides has the somatotrophic effect of weightening finish to broiler, and immunologic function is had facilitation, can improve anti-bacteria and anti-virus ability with enhancing human body immunity power, improve meat.This Chinese traditional immunopoteniators not only has important regulation effect to broiler immune organ, immunocyte and specific immune function, but also can effectively reduce drug residue and the pathogenic microorganism residual of animal product.
Description
Technical field
The present invention relates to herbal medicine technical field, particularly relate to a kind of for improving broiler immunization machine in process of production
The Chinese traditional immunopoteniators of energy.
Background technology
Broiler production is one of important industry of China's animal husbandry development, of Ye Shi China livestock products foreign exchange earning
Mainstay.For a long time, China's broiler production, along being main body in order to vaccine, environmental Kuznets Curves, coordinates chemical medicine, the veterinary of antibiotic
Epidemic prevention system, its result is chemicals, hormone, antibiotic remains, cause animal produce drug resistance, cause carcinogenic, teratogenesis and
Mutagenesis, and human health can be endangered by food chain, human health and public health are constituted the biggest threat.
It addition, developed countries such as China broiler product main exit America and Europe, Japan, Korea S, these countries are to import poultry
The microbiological contamination of product, medicine are residual etc. has formulated strict standard, and China's part commercial meat bird exists in producing always
Serious drug residue problem, thus result in the present situation that Carnis Gallus domesticus outlet is difficult, constrain the healthy and stable development of Chicken industry,
After WTO, foreign government is often as the broiler product that excuse refusal import is Chinese.
Due to long-term a large amount of Drug abuse, irrational vaccination, immunosuppressive disease be widely present and various should
Sharp factor causes meat chicken production performance and immunologic function degression, therefore, how to improve meat chicken production performance and enhancing human body immunity
Function is always the focus of animal and veterinary focus of attention.
Along with improving constantly of living standards of the people, the self health consciousness of people gradually strengthens, and Chinese herbal medicine can not only carry
The production performance of high broiler and feed conversion rate, be effectively improved meat flavor, and many Chinese herbal medicine have immunological enhancement,
The non-specific of body and specific immune function can be improved, the resistance of enhancing body, plays good growth promotion and disease-resistant
Effect, produces green non-pollution broiler product using Chinese herbal medicine as immunostimulant, increasingly by the extensive concern of society.In
Medical herbs feed additive is in modernization, intensive farm produce, and plays Chinese herbal medicine disease-prevention health, promotes growth, without drug resistance
Property etc. the product that gets up of superiority development, there is natural sex, multifunctionality, toxic and side effects is little, it is harmful residual to be difficult in meat to produce
The advantage such as stay to be increasingly subject to favor.
Motherland's medical science thinks " healthy energy deposit in, heresy can not be done ", " being gathered of heresy, its gas must void ".This viewpoint has affirmed machine
Body healthy energy (endogenous cause of ill) has conclusive effect to whether falling ill.Used by the present invention, Chinese traditional immunopoteniators is namely based on Chinese medicine
This viewpoint, from safeguard consolidate internal healthy energy, improvement and enhancing body resistance set about composition.
Summary of the invention
The technical problem to be solved is to provide a kind of novel exempt from for improving in feeding of broiler growth course
The Chinese traditional immunopoteniators of epidemic disease function, it has the somatotrophic effect of weightening finish, has facilitation to immunologic function broiler, permissible
Enhancing human body immunity power, improves anti-bacteria and anti-virus ability, improves meat.This Chinese traditional immunopoteniators is not only to broiler immunity device
Official, immunocyte and specific immune function have important regulation effect, but also can effectively reduce the medicine of animal product
Thing residual and pathogenic microorganism remain.
In order to solve above-mentioned technical problem, the invention provides a kind of for improving the broiler immune merit in growth course
The Chinese traditional immunopoteniators of energy, its crude drug includes Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Radix Platycodonis, Radix Phytolaccae, Fructus Psoraleae, Fructus Crataegi, Rhizoma Dioscoreae, gold silver
Flower, Caulis Sargentodoxae, Fructus Cnidii, Herba Artemisiae Annuae, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Rhizoma Polygonati, Fructus Lycii, Radix Glehniae, Radix Angelicae Sinensis, Radix Isatidis, Herba Visci, Radix Polygoni Multiflori,
Caulis Fibraureae, Xi, Herb Gynostemmae Pentaphylli and Radix Glycyrrhizae.
Wherein, in described Chinese traditional immunopoteniators, the weight portion of each crude drug is respectively Radix seu Herba Gei aleppici 45～55 weight portion, bamboo
JIESHEN 40～50 weight portion, Radix Platycodonis 20～30 weight portion, Radix Phytolaccae 25～35 weight portion, Fructus Psoraleae 50～60 weight portion, Fructus Crataegi 20
～30 weight portions, Rhizoma Dioscoreae 70～80 weight portion, Flos Lonicerae 25～35 weight portion, Caulis Sargentodoxae 20～30 weight portion, Fructus Cnidii 35～
45 weight portions, Herba Artemisiae Annuae 15～25 weight portion, the Rhizoma Atractylodis Macrocephalae 40～50 weight portion, Cortex Cinnamomi 20～30 weight portion, Rhizoma Polygonati 45～55 weight portion,
Fructus Lycii 35～45 weight portion, Radix Glehniae 40～50 weight portion, Radix Angelicae Sinensis 30～40 weight portion, Radix Isatidis 20～30 weight portion, Mongolian oak
Parasitic 35～45 weight portions, Radix Polygoni Multiflori 30～40 weight portion, Caulis Fibraureae 20～30 weight portion, Xi 15～25 weight portion, Herb Gynostemmae Pentaphylli
30～40 weight portions and Radix Glycyrrhizae 25～35 weight portion.
Wherein, in described Chinese traditional immunopoteniators, the weight portion of each crude drug is respectively Radix seu Herba Gei aleppici 50 weight portion, Rhizoma Panacis Japonici
45 weight portions, Radix Platycodonis 25 weight portion, Radix Phytolaccae 30 weight portion, Fructus Psoraleae 55 weight portion, Fructus Crataegi 25 weight portion, Rhizoma Dioscoreae 75 weight portion,
Flos Lonicerae 30 weight portion, Caulis Sargentodoxae 25 weight portion, Fructus Cnidii 40 weight portion, Herba Artemisiae Annuae 20 weight portion, the Rhizoma Atractylodis Macrocephalae 45 weight portion, Cortex Cinnamomi 25
Weight portion, Rhizoma Polygonati 50 weight portion, Fructus Lycii 40 weight portion, Radix Glehniae 45 weight portion, Radix Angelicae Sinensis 35 weight portion, Radix Isatidis 25 weight
Part, Herba Visci 40 weight portion, Radix Polygoni Multiflori 35 weight portion, Caulis Fibraureae 25 weight portion, Xi 20 weight portion, Herb Gynostemmae Pentaphylli 35 weight portion and sweet
Grass 30 weight portions.
Present invention also offers the preparation method of above-mentioned Chinese traditional immunopoteniators, the dosage form of described Chinese traditional immunopoteniators is
Injection, described method includes:
The first step, by Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Radix Glehniae, Fructus Lycii, Herba Visci, Herb Gynostemmae Pentaphylli and
Xi is mixed in proportion, and takes mixture 100g and loads in percolator, adds Chinese liquor 600g～800g of 50 DEG C～55 DEG C, at 25 DEG C
～soak 20 hours～30 hours under conditions of 35 DEG C, regulate percolator valve, make Chinese liquor medicinal liquid slowly ooze, oozing speed is
Per minute 2～4mL, collect drip, obtain the percolate of 700mL～1L, concentrate, remove Chinese liquor, dry, pulverize, it is thus achieved that be dried
Powder；
Second step, is mixed in proportion component under She, takes 100g mixture, adds the water of 500g～800g, boils 3～4
Hour, filtering, it is thus achieved that the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filters, it is thus achieved that
Second filtrate, mixes the first filtrate and the second filtrate, adds the powder being dried that the first step obtains, stirs the most molten to powder
Solving, concentrate, remove part water, the volume to solution is 100mL, cold preservation at a temperature of 0 DEG C, filters, and filtrate adds 10%
Activated carbon decolorizing, Ex-all activated carbon, with 10% sodium hydroxide solution regulation pH value to 6.5～7.5, embedding, sterilizing, obtain note
Penetrate liquid.
Present invention also offers the preparation method of above-mentioned Chinese traditional immunopoteniators, the dosage form of described Chinese traditional immunopoteniators is
Decoction liquor, described method includes:
The first step, by Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Radix Glehniae, Fructus Lycii, Herba Visci, Herb Gynostemmae Pentaphylli and
Xi is mixed in proportion, and takes mixture 100g and loads in percolator, adds Chinese liquor 600g～800g of 50 DEG C～55 DEG C, at 25 DEG C
～soak 20 hours～30 hours under conditions of 35 DEG C, regulate percolator valve, make Chinese liquor medicinal liquid slowly ooze, oozing speed is
Per minute 2～4mL, collect drip, obtain the percolate of 700mL～1L, concentrate, remove Chinese liquor, dry, pulverize, it is thus achieved that be dried
Powder；
Second step, is mixed in proportion component under She, takes 100g mixture, adds the water of 500g～800g, boils 3～4
Hour, filtering, it is thus achieved that the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filters, it is thus achieved that
Second filtrate, mixes the first filtrate and the second filtrate, adds the powder being dried that the first step obtains, stirs the most molten to powder
Solving, concentrating crude drug concentration is 1g/mL, it is thus achieved that decoction liquor.
Present invention also offers the preparation method of above-mentioned Chinese traditional immunopoteniators, described Chinese traditional immunopoteniators for feedstuff
Additive powder, described method includes:
The first step, by Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Radix Glehniae, Fructus Lycii, Herba Visci, Herb Gynostemmae Pentaphylli and
Xi is mixed in proportion, and takes mixture 100g and loads in percolator, adds Chinese liquor 600g～800g of 50 DEG C～55 DEG C, at 25 DEG C
～soak 20 hours～30 hours under conditions of 35 DEG C, regulate percolator valve, make Chinese liquor medicinal liquid slowly ooze, oozing speed is
Per minute 2～4mL, collect drip, obtain the percolate of 700mL～1L, concentrate, remove Chinese liquor, dry, pulverize, it is thus achieved that be dried
The first powder；
Second step, is mixed in proportion component under She, takes 100g mixture, adds the water of 500g～800g, boils 3～4
Hour, filtering, it is thus achieved that the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filters, it is thus achieved that
Second filtrate, mixes the first filtrate and the second filtrate, concentrates and removes water, it is thus achieved that the second dry powder, by the first powder with
Second powder mixing, it is thus achieved that feed additive powder.
Present invention also offers a kind of Chinese medicine feed additive for improving broiler immunologic function in growth course,
The crude drug of described Chinese medicine feed additive includes Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Radix Platycodonis, Radix Phytolaccae, Fructus Psoraleae, Fructus Crataegi, Rhizoma Dioscoreae, gold silver
Flower, Caulis Sargentodoxae, Fructus Cnidii, Herba Artemisiae Annuae, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Rhizoma Polygonati, Fructus Lycii, Radix Glehniae, Radix Angelicae Sinensis, Radix Isatidis, Herba Visci, Radix Polygoni Multiflori,
Caulis Fibraureae, Xi, Herb Gynostemmae Pentaphylli and Radix Glycyrrhizae.
The present invention also provides for a kind of for feedstuff, and it includes main feed and above-mentioned feed additive, relative to 100 weight
The main feed of part, the addition of described feed additive is 15 weight portions～18 weight portions.
Wherein, described main feed is Fructus Hordei Vulgaris, Semen Tritici aestivi, Semen Maydis.
Present invention also offers the preparation method of above-mentioned feedstuff, comprising:
The first step, prepares described feed additive powder according to the method described above；
Second step, is mixed in main feed in proportion by above-mentioned feed additive powder.
Beneficial effects of the present invention:
The Chinese traditional immunopoteniators that the present invention provides has the somatotrophic effect of weightening finish to broiler, and immunologic function is had promotion
Effect, can improve anti-bacteria and anti-virus ability with enhancing human body immunity power, improves meat.This Chinese traditional immunopoteniators is not only to meat
Immune Organs of Chicken, immunocyte and specific immune function have important regulation effect, but also can effectively reduce animal
The drug residue of product and pathogenic microorganism residual.
Detailed description of the invention
Chinese traditional immunopoteniators is the natural Chinese medicine utilizing China's abundant, according to modern Chinese veterinarian's pharmacology opinion scientific composition,
For improving the Chinese medicine preparation of the immunologic function of body.Chinese traditional immunopoteniators effect in terms of improving the immunologic function of broiler
Mechanism is particularly as follows: 1. promote Development of Immune Organs: increase weight and the index of the immune organs such as spleen gland, spleen and bud fabricius bursa,
The atrophy of immune organ that antagonism immunologic injury such as cycli phosphate amine, lonizing radiation etc. are caused；2. strengthen cellular immune function: activate and increase
The thin marrow function of strong immunity, including T, bone-marrow-derived lymphocyte, the burnt born of the same parents of N, mononuclear phagocyte and leukocyte etc..As promoted lymphocyte DNA
Synthesis, improve lymhocyte transformation rate, T lymphocyte percentage, activating macrophage function, strengthen it and swallow, process, pass
Pass the effect of antigen；3. strengthen humoral immunization: promote synthesis and the secretion of antibody, extend antibody and there is time, enhancement antigen thing
The immunogenicity of matter and stability；4. promote cytokine secretion and activity: as promoted interleukin, interferon, tumor bad
The secretion of necrosis factor etc. and activity；5. the immune impairment such as antagonism lonizing radiation, chemicals, cancerous cell, recovers spleen and lymphatic system
The function etc. of system.
The immunocompetence of human body body is body defenses and removes pathogenic microorganism and harmful substance, to keep and just to recover
The often ability of physiological action.The strengthening by means of tonics class medicine of Chinese herbal medicine and part eliminating evil class medicine have and promote low immunoreation
Effect, can improve body immune system function.Rich in bioactive substance in natural plants, scalable internal body resist the disease
Ability, improve body non-specific immunity, strengthen the diseases prevention power of body on the whole.
Phagocyte has foreign body phagocytosis and the function of digestion, plays an important role in body inherent immunity, in
Medicine also has the effect improving phagocyte phagocytic function.Erythrocyte has removing immune complex, promotes that phagocytosis, identification are anti-
Former, present antigen, immunomodulating and the effect of participation anti-tumor in vivo immunity, can strengthen erythrocytic immunologic function.
The immunoregulation effect of Chinese medicine is not the immunological effect of simple function, but close and Neuroendocrine regulation
(MM) function system that network is associated.It both can directly affect the substance metabolism of immunocyte, and immunity of organism can be induced again thin
Born of the same parents produce relevant cytokine (such as: interleukin, interferon etc.)；Both can the humoral immunization of enhancing body, again can enhancing body
Cellular immunization；Both the immunologic function of normal body, the again immunologic function of scalable exception body can have been strengthened, can be from immunity device
Official-cell-molecule or even gene transcription level regulate immune state and the function of body.
Chinese veterinarian thinks, the process of any disease, is all the process of healthy energy and pathogen contradiction both sides struggle.Therefore, treatment
Basic goal seek to reinforcing body resistance, eliminating pathogens, recover the relative equilibrium of body negative and positive, make disease processes to recovery from illness direction
Convert.So-called righting, it is simply that use the square medicine of tonification healthy energy, to improve the resistivity of body, reach eliminating evil gas, defeat disease
Disease, restorative purpose.The weight that Chinese medicine immunopotentiating agent not only has the production performance improving broiler, increases immune organ
The antibody titer with index, improving vaccine, the various immunologic functions strengthening chicken, moreover it is possible to complement activation, promote that cytokine generates,
Strengthening hematid immunity function etc., immune system is played many regulation effects, the present invention is exactly to propose on this basis
A kind of Chinese traditional immunopoteniators for improving broiler immunologic function in growth course, its crude drug includes Radix seu Herba Gei aleppici, bamboo
JIESHEN, Radix Platycodonis, Radix Phytolaccae, Fructus Psoraleae, Fructus Crataegi, Rhizoma Dioscoreae, Flos Lonicerae, Caulis Sargentodoxae, Fructus Cnidii, Herba Artemisiae Annuae, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Rhizoma Polygonati, Fructus Lycii
Son, Radix Glehniae, Radix Angelicae Sinensis, Radix Isatidis, Herba Visci, Radix Polygoni Multiflori, Caulis Fibraureae, Xi, Herb Gynostemmae Pentaphylli and Radix Glycyrrhizae.
Fang Zhong, Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Cnidii, Rhizoma Polygonati, Fructus Lycii broiler immunologic function is had significantly promote make
With, they can activate body immune system, improves quantity and effect of immunologically competent cell, increase immunocyte growth and
The synthesis of antibody, thus improve the premunition of body, maintaining organismic internal environment balance, the platycodon root polysaccharide in Radix Platycodonis can significantly improve
The generation of polyclonal antibody IgM and the propagation of B cell, Radix Phytolaccae can significantly improve chicken T lymhocyte transformation rate, can significantly improve it
The Nonspecific immunity function of body, Fructus Psoraleae can significantly improve erythrocyte C3The promotion rate of b receptor garland, significantly reduces
Erythrocyte C3The suppression ratio of b receptor garland, notable or pole significantly improves erythrocyte C3B receptor rosette rate, it is thin that pole significantly improves lymph
Dysuria with lower abdominal colic rate, can strengthen the immunocompetence of heat stress broiler, and Fructus Crataegi can increase the secretion of digestive enzyme, facilitating digestion in stomach, and contains
Having lipase, can strengthen the activity of gastric lipase, protease, Xi has stronger antibacterial action to dysentery bacterium, to bacillus pyocyaneus,
Gold-coloured staphylococci, escherichia coli, Bacillus proteus, anthrax bacillus, streptococcus, Bacillus typhi etc. all have an antibacterial action, Herba Visci,
Rhizoma Dioscoreae can promote healthy carcass lymhocyte transformation rate, increases the quantity of T cell, improves the huge ability of biting thus improve immunity of organism
Power, Flos Lonicerae, Caulis Fibraureae have the multiple medicine such as broad-spectrum antiseptic, antiviral, antitumor, immunostimulant and antipyretic and anti-inflammatory, function of gallbladder promoting profit liver
Reason effect, Caulis Sargentodoxae can increase the quantity of blood middle leukocytes, improves the phagocytic function of chicken abdominal cavity mononuclear phagocyte system, blue or green
Artemisia can resisting pathogenic microbes, antiendotoxin, antiinflammatory, antipyretic, analgesia, immunomodulating, improve hemopoietic function, improve immunity of organism
Power, the Rhizoma Atractylodis Macrocephalae can substantially increase serum IgG, improves body resistance against diseases, and Cortex Cinnamomi warming spleen and stomach for dispelling cold, recuperating depleted YANG and rescuing the patient from collapse, Radix Glehniae can extend
The time that antibody exists in chicken body, Radix Angelicae Sinensis has anti-platelet aggregation and anti thrombotic action, can promote hemoglobin and erythrocyte
Generation, and can the specificity of enhancing body and non-specific immunity, Radix Isatidis has antiinflammatory, antiviral, antipyretic and increase
The effects such as strong immunity, Radix Polygoni Multiflori is improved body's immunity, anti-stress effect and improve the several functions such as Nutrition and Metabolism, strand
Indigo plant can improve serum hemolysis cellulose content, illustrates that it has facilitation, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription to humoral immunization, and all medicines are coordinated, each other
Wu Yong, so that renal function is coordinated, vital essence fills, and makes taste essence of water and grain be operated in time, to meet body nutrition need
, full side fills blood, liver and kidney tonifying, strengthening the spleen and stomach serve integrally-regulated effect to broiler, to Abwehrkraft des Koepers, adaptive faculty and immunity
Power has good mediating effect+6, and has class gonadotropic Effect, thus organism metabolism creates good comprehensive adjustment effect.
Further, described Chinese traditional immunopoteniators is only made up of above-mentioned raw materials medicine.
In described Chinese traditional immunopoteniators, the weight portion of each crude drug is respectively as follows: Radix seu Herba Gei aleppici 45～55 weight portion, Rhizoma Panacis Japonici
40～50 weight portions, Radix Platycodonis 20～30 weight portion, Radix Phytolaccae 25～35 weight portion, Fructus Psoraleae 50～60 weight portion, Fructus Crataegi 20～30
Weight portion, Rhizoma Dioscoreae 70～80 weight portion, Flos Lonicerae 25～35 weight portion, Caulis Sargentodoxae 20～30 weight portion, Fructus Cnidii 35～45 weight
Amount part, Herba Artemisiae Annuae 15～25 weight portion, the Rhizoma Atractylodis Macrocephalae 40～50 weight portion, Cortex Cinnamomi 20～30 weight portion, Rhizoma Polygonati 45～55 weight portion, Fructus Lycii
Son 35～45 weight portions, Radix Glehniae 40～50 weight portion, Radix Angelicae Sinensis 30～40 weight portion, Radix Isatidis 20～30 weight portion, Herba Visci
35～45 weight portions, Radix Polygoni Multiflori 30～40 weight portion, Caulis Fibraureae 20～30 weight portion, Xi 15～25 weight portion, Herb Gynostemmae Pentaphylli 30～
40 weight portions and Radix Glycyrrhizae 25～35 weight portion.
In described Chinese traditional immunopoteniators, the weight portion of each crude drug is further preferably respectively as follows: Radix seu Herba Gei aleppici 48～52 weight
Part, Rhizoma Panacis Japonici 43～47 weight portion, Radix Platycodonis 23～27 weight portion, Radix Phytolaccae 28～32 weight portion, Fructus Psoraleae 53～57 weight portion, mountain
Short, bristly hair or beard 23～27 weight portion, Rhizoma Dioscoreae 73～77 weight portion, Flos Lonicerae 28～32 weight portion, Caulis Sargentodoxae 23～27 weight portion, Fructus Cnidii
38～42 weight portions, Herba Artemisiae Annuae 18～22 weight portion, the Rhizoma Atractylodis Macrocephalae 43～47 weight portion, Cortex Cinnamomi 23～27 weight portion, Rhizoma Polygonati 48～52 weight
Amount part, Fructus Lycii 38～42 weight portion, Radix Glehniae 43～47 weight portion, Radix Angelicae Sinensis 33～37 weight portion, Radix Isatidis 23～27 weight
Part, Herba Visci 38～42 weight portion, Radix Polygoni Multiflori 33～37 weight portion, Caulis Fibraureae 23～27 weight portion, Xi 18～22 weight portion, strand
Blue 33～37 weight portions of stock and Radix Glycyrrhizae 28～32 weight portion.
In described Chinese traditional immunopoteniators, the weight portion of each crude drug is most preferably respectively as follows: Radix seu Herba Gei aleppici 50 weight portion, ring
Join 45 weight portions, Radix Platycodonis 25 weight portion, Radix Phytolaccae 30 weight portion, Fructus Psoraleae 55 weight portion, Fructus Crataegi 25 weight portion, Rhizoma Dioscoreae 75 weight
Part, Flos Lonicerae 30 weight portion, Caulis Sargentodoxae 25 weight portion, Fructus Cnidii 40 weight portion, Herba Artemisiae Annuae 20 weight portion, the Rhizoma Atractylodis Macrocephalae 45 weight portion, meat
Osmanthus 25 weight portion, Rhizoma Polygonati 50 weight portion, Fructus Lycii 40 weight portion, Radix Glehniae 45 weight portion, Radix Angelicae Sinensis 35 weight portion, Radix Isatidis 25 weight
Amount part, Herba Visci 40 weight portion, Radix Polygoni Multiflori 35 weight portion, Caulis Fibraureae 25 weight portion, Xi 20 weight portion, Herb Gynostemmae Pentaphylli 35 weight portion and
Radix Glycyrrhizae 30 weight portion.
Present invention also offers the preparation method of above-mentioned Chinese traditional immunopoteniators, the dosage form of described Chinese traditional immunopoteniators is
Injection, described method includes:
The first step, by Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Radix Glehniae, Fructus Lycii, Herba Visci, Herb Gynostemmae Pentaphylli and
Xi is mixed in proportion, and takes mixture 100g and loads in percolator, adds Chinese liquor 600g～800g of 50 DEG C～55 DEG C, at 25 DEG C
～soak 20 hours～30 hours under conditions of 35 DEG C, regulate percolator valve, make Chinese liquor medicinal liquid slowly ooze, oozing speed is
Per minute 2～4mL, collect drip, obtain the percolate of 700mL～1L, concentrate, remove Chinese liquor, dry, pulverize, it is thus achieved that be dried
Powder；
Second step, is mixed in proportion component under She, takes 100g mixture, adds the water of 500g～800g, boils 3～4
Hour, filtering, it is thus achieved that the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filters, it is thus achieved that
Second filtrate, mixes the first filtrate and the second filtrate, adds the powder being dried that the 100g first step obtains, stirs complete to powder
CL, concentrates, and removes part water, and the volume to solution is 100mL, cold preservation at a temperature of 0 DEG C, filters, and filtrate adds
The activated carbon decolorizing of 10%, Ex-all activated carbon, with 10% sodium hydroxide solution regulation pH value to 6.5～7.5, embedding, sterilizing, i.e.
Obtain injection.
Present invention also offers the preparation method of above-mentioned Chinese traditional immunopoteniators, the dosage form of described Chinese traditional immunopoteniators is
Decoction liquor, described method includes:
The first step, by Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Radix Glehniae, Fructus Lycii, Herba Visci, Herb Gynostemmae Pentaphylli and
Xi is mixed in proportion, and takes mixture 100g and loads in percolator, adds Chinese liquor 600g～800g of 50 DEG C～55 DEG C, at 25 DEG C
～soak 20 hours～30 hours under conditions of 35 DEG C, regulate percolator valve, make Chinese liquor medicinal liquid slowly ooze, oozing speed is
Per minute 2～4mL, collect drip, obtain the percolate of 700mL～1L, concentrate, remove Chinese liquor, dry, pulverize, it is thus achieved that be dried
Powder；
Second step, is mixed in proportion component under She, takes 100g mixture, adds the water of 500g～800g, boils 3～4
Hour, filtering, it is thus achieved that the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filters, it is thus achieved that
Second filtrate, mixes the first filtrate and the second filtrate, adds the powder being dried that the first step obtains, stirs the most molten to powder
Solving, concentrating crude drug concentration is 1g/mL, it is thus achieved that decoction liquor.
Present invention also offers the preparation method of above-mentioned Chinese traditional immunopoteniators, described Chinese traditional immunopoteniators for feedstuff
Additive powder, described method includes:
The first step, by Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Radix Glehniae, Fructus Lycii, Herba Visci, Herb Gynostemmae Pentaphylli and
Xi is mixed in proportion, and takes mixture 100g and loads in percolator, adds Chinese liquor 600g～800g of 50 DEG C～55 DEG C, at 25 DEG C
～soak 20 hours～30 hours under conditions of 35 DEG C, regulate percolator valve, make Chinese liquor medicinal liquid slowly ooze, oozing speed is
Per minute 2～4mL, collect drip, obtain the percolate of 700mL～1L, concentrate, remove Chinese liquor, dry, pulverize, it is thus achieved that be dried
The first powder；
Second step, is mixed in proportion component under She, takes 100g mixture, adds the water of 500g～800g, boils 3～4
Hour, filtering, it is thus achieved that the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filters, it is thus achieved that
Second filtrate, mixes the first filtrate and the second filtrate, concentrates and removes water, it is thus achieved that the second dry powder, by the first powder with
Second powder mixing, it is thus achieved that feed additive powder.
The present invention also provides for a kind of for feedstuff, and it includes main feed and above-mentioned feed additive powder, relative to 100
The main feed of weight portion, the addition of described feed additive powder is 15 weight portions～18 weight portions.
Described main feed can be the conventional feed of the eaten by broilers such as Fructus Hordei Vulgaris, Semen Tritici aestivi, Semen Maydis.
Present invention also offers the preparation method of above-mentioned feedstuff, comprising:
The first step, prepares described feed additive powder according to the method described above；
Second step, is mixed in main feed in proportion by above-mentioned feed additive powder.
The pharmacology of each crude drug is as follows:
Radix seu Herba Gei aleppici: latin name Gei Herba, acrid in the mouth, hardship, property puts down, returns liver, spleen, lung meridian, have an analgesia, blood pressure lowering, regulating menstruation,
Effect of expelling wind and removing dampness, cures mainly hypertension, dizziness headache, menoxenia, lower abdominal pain, leucorrhea, infantile convulsion, rheumatism waist-leg
Bitterly；The cards such as carbuncle furuncle and phyma poison is controlled in external, traumatic injury.
Rhizoma Panacis Japonici: latin name Panacis Japonici Rhizoma, sweet in the mouth, micro-hardship, warm in nature, return liver, spleen, lung meridian, tool
Having strengthening by means of tonics, eliminating stasis to stop pain, effect that hemostasis is eliminated the phlegm, cure mainly weak after being ill, chronic cough is spat blood, cough with copious phlegm, injury from falling down etc.
Card.
Radix Platycodonis: bitter in the mouth, pungent, slightly warm in nature, enter lung meridian, there is expelling phlegm for arresting cough, effect of lung qi dispersing evacuation of pus, cure mainly cough with copious phlegm,
Laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis etc. are demonstrate,proved.
Radix Phytolaccae: latin name Phytolaccae Radix, bitter in the mouth, cold in nature, to return spleen, bladder warp, have logical two just, removing water retention by purgation dissipates
Effect of knot, cures mainly edema, distension, tinea pedis, sore throat, carbuncle, and malignant boil etc. is demonstrate,proved.
Fructus Psoraleae: latin name Psoraleae Fructus, acrid in the mouth, hardship, warm in nature, enter kidney, spleen channel, have kidney invigorating and YANG supporting, warming the spleen
The effect of antidiarrheal, is mainly used in decline of the fire from the gate of life, the chills and pain of the waist and kness of below element deficiency and cold, frequent urination and enuresis, sexual impotence lingering diarrhea；Insufficiency of kidney-YANG, spleen
The cards such as soil loses using warming therapy stomachache limb and trembles with fear, Diarrhoea.
Fructus Crataegi: latin name Crataegi Fructus, sour in the mouth, sweet, slightly warm in nature, return spleen, stomach, Liver Channel, for promoting digestion and invigorating the stomach,
Circulation of qi promoting dissipating blood stasis, is mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, has loose bowels, dysentery, and Fructus Crataegi is the regular supplies for the treatment of dyspepsia, and Fructus Crataegi can increase
The secretion of peptic digestion enzyme, facilitating digestion；Dysentery bacterium, escherichia coli, bacillus pyocyaneus, staphylococcus aureus etc. are had substantially
Inhibitory action.
Rhizoma Dioscoreae: sweet in the mouth, property put down, enter lung, spleen, kidney channel, have strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, reinforce the kidney benefit essence, hearing-improing and eyesight improving,
Help the five internal organs, bone and muscle strengthening, long will to calm the nerves, effect of life lengthening, cure mainly weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea long
Dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity is weak, frequent micturition of quenching one's thirst, seminal emission premature ejaculation, leukorrhagia nebulousurine, skin
The red card such as swollen, fat of skin.
Flos Lonicerae: sweet in the mouth, cold in nature, enters the heart, lung, stomach, large intestine channel, has the effect of heat-clearing and toxic substances removing, and holding concurrently can eliminating pathogenic heat from blood to cure dysentery.Mainly
Relatively contain for affection due to external wind and heat, epidemic febrile disease pyretic toxicity, or when epidemic febrile disease is still the most descending at the part of the body cavity above the diaphragm housing the heart and lungs from the beginning of pathogenic heat；Under pyretic toxicity dysentery, stool
Blood；Fever disease in summer is demonstrate,proved；The carbuncle sore of pyretic toxicity accumulation is from the beginning of, the heat person of swelling and ache etc., and Flos Lonicerae has preferable antipyretic effect, can antiinflammatory, control
Oozing out and inflammatory hyperplasia of inflammation, can promote the phagocytic function of leukocyte, has multiple pyococcus and pathogenic entero becteria relatively
Strong bacteriostasis, including staphylococcus, Hemolytic streptococcus, meningococcus, dysentery bacterium, Bacillus typhi, green pus bar
Bacterium, tubercule bacillus etc., Flos Lonicerae is all effective to the pyretic toxicity of QI and blood battalion point, and has broad-spectrum antibacterial action.
Caulis Sargentodoxae: latin name Sargentodoxae Caulis, bitter in the mouth, property is flat, returns liver, large intestine channel, has the eliminating carbuncle that relieves internal heat,
Promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide, cure mainly acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm
Bitterly, the card such as injury from falling down.
Fructus Cnidii: latin name Cnidii Fructus, acrid in the mouth, hardship, warm in nature, enter kidney channel, there is warming the kidney to invigorate YANG, dampness is killed
Worm, the effect of dispelling wind for relieving itching, the impotence in male, the woman's cold womb that cause for kidney yang deficiency are infertile, cold-damp leukorrhagia or chills and pain of the waist and kness
Deng card.
Herba Artemisiae Annuae: latin name Artemisiae Annuae Herba, bitter in the mouth, pungent, cold in nature, return liver, gallbladder meridian, there is clear void
Heat, removing heat from blood is except steaming, except steaming, effect of preventing the attack (or recurrence) of malaria, cure mainly pathogenic summer-heat and generate heat, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat,
Jaundice due to damp-heat etc. are demonstrate,proved.
The Rhizoma Atractylodis Macrocephalae: latin name Attractylodis Macrocephalae Rhizoma, sweet in the mouth, hardship, warm in nature, enter spleen, stomach
Warp, has spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, effect that activating the spleen is moisturized, and cures mainly the painful abdominal mass caused by dysfunction of the spleen in transportation, QI failing to transform into body fluid
Have one's mind filled with and rush down, phlegm retention edema；The vexed lazy speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery；Solid, sweating due to debility in the playing of deficiency of the spleen causing weakness of QI
Spontaneous perspirations etc. are demonstrate,proved, and the Rhizoma Atractylodis Macrocephalae can promote gastric secretion, strengthen the Absorption of small intestinal, have regulation effect to gastrointestinal function.
Cortex Cinnamomi: extremely hot in nature, acrid in the mouth, sweet, return kidney, spleen, the heart, Liver Channel, there is benefit fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, live
Effect that blood stimulates the menstrual flow, for warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Controlling decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels,
The cards such as colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun are floating more, heat in the upper and cold in the lower.
Rhizoma Polygonati: sweet in the mouth, property is put down, is entered lung, spleen, kidney channel, have enriching qi and yin, spleen invigorating lung moistening, effect of enriching kidney essence, be used for
Taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, quenching one's thirst of yin asthenia generating intrinsic heat, deficiency of kidney essence, impotence and seminal emission, dizziness
Tinnitus, blurred vision dim eyesight etc. are demonstrate,proved.
Fructus Lycii: sweet in the mouth, property are flat, enter liver, kidney channel, have liver and kidney tonifying, nourish blood enrich blood, the work of replenishing vital essence to improve eyesight, nourishing the lung to arrest cough
With, it is mainly used in liver and kidney deficiency, the soreness of the waist and knees of asthenia of essence and blood, dizziness and tinnitus, seminal emission tinnitus, unconsciously sweat and tire；Insufficiency of kidney-YANG it
Sexual impotence, sterile；Deficiency of YIN-essence, deficiency of liver-blood eyes is dim-sighted and the card such as deficiency of YIN chronic cough.
Radix Glehniae: latin name Glehniae Radix, sweet in the mouth, micro-hardship, cold nature, there is nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid
Effect, for cards such as lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound are thirsty, Rhizoma Polygonati and Radix Glehniae are used in combination and can be used for treating spleen
The diseases such as deficiency of stomach-YIN, hunger but having no desire to eat, gastral cavity abdomen do not relax, dryness of the mouth and throat, red tongue with a little fluid.
Radix Angelicae Sinensis: sweet in the mouth, pungent, bitter, warm in nature, enter liver, the heart, spleen channel, there is replenishing and activating blood, menstruction regulating and pain relieving, the work of profit soup relieving constipation
With, for blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, fall and flutter damage
Wound, ulcer sores etc. are demonstrate,proved.
Radix Isatidis: latin name Isatidis Radix, bitter in the mouth, cold in nature, enter the heart, liver, gallbladder, stomach warp, have heat-clearing and toxic substances removing, removing heat from blood
The effect of sore-throat relieving, is used for treating maculae caused by violent heat pathogen；High heat headache；Major part pestilence；Crimson tongue is purple dark, scarlet fever；Erysipelas；Mumps；Larynx
Numbness；Skin ulcer is swollen, carbuncle；Chickenpox；Measles；Hepatitis；Influenza, epidemic encephalitis, encephalitis b, pneumonia, coma tells nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer
Rash；The cards such as epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis can be prevented and treated.
Herba Visci: bitter in the mouth, sweet, property is put down.Return liver, kidney channel, there is relaxing muscles and tendons and activating QI and blood in the collateral, effect of promoting blood circulation to remove blood stasis, cure mainly fetal movement not
Peace, vaginal bleeding during pregnancy hematochezia, bones and muscles pain, limbs contracture, aching pain in waist and back, traumatic injury etc. is demonstrate,proved.
Radix Polygoni Multiflori: bitter in the mouth, sweet, puckery, slightly warm in nature, return liver, kidney channel, there is effect of nourishing the blood and yin, loosening bowel to relieve constipation, cure mainly blood
Empty Light-headedness；Cardiopalmus；Insomnia；The soreness of the waist and knees of the hepatic and renal YIN deficiency；Early whitening of beard and hair；Tinnitus；Seminal emission；Dryness of the intestine constipation；Chronic malaria body is empty；
Rubella pruritus；Carbuncle sore；Scrofula；Hemorrhoid etc. are demonstrate,proved.
Caulis Fibraureae: bitter in the mouth, cold in nature, GUIXIN, Liver Channel, there is heat-clearing and toxic substances removing, effect of pathogenic fire purging relieving constipation, cure mainly dominance of heat in the interior, just
Secret, dysentery, laryngopharynx swelling and pain, the cards such as conjunctival congestion is red and swollen, carbuncle sore tumefacting virus.
Xi: latin name Thlaspi Herba, acrid in the mouth, cold nature, return liver, stomach, large intestine channel, has a liver heat removing and eyesight improving, and in
Dampness removing, effect of removing toxic substances and promoting subsidence of swelling, for conjunctival congestion and swelling pain, abdominal distention, hypochondriac pain, acute appendicitis, edema, carry inferior card.
Herb Gynostemmae Pentaphylli: another name Herba Gynostemmatis, Pentapanax, gynostemma pentaphyllum makino, Herba Gynostemmatis, Herb Gynostemmae Pentaphylli, Radix Rhodiolae, the sweet bitter edible plant are climing, southerner
Ginseng, cold in nature, bitter in the mouth, to return lung, spleen, kidney channel, have QI invigorating, calm the nerves, effect of blood pressure lowering, for deficiency of vital energy and physically weak, few gas is weak；Vexed
Insomnia；Hypertension, Light-headedness；Viral hepatitis；Digestive tract tumor；Chronic bronchitiss etc. are demonstrate,proved, through modern medicine study
Finding, Herb Gynostemmae Pentaphylli principle active component is polysaccharide, flavonoid, saponins and microelement kind, and its effect is chiefly to facilitate people
Body fat class substance metabolism, nutrition human body cell, have good detoxicating, relieving inflammation effect simultaneously.
Radix Glycyrrhizae: sweet in the mouth, property puts down, enters 12 warps, have a heat-clearing and toxic substances removing, is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and
In, relieving spasm to stop pain, it is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak；Contracture pain in abdomen can be alleviated, relax some drugs
Strong and toxicity, alleviate medicine to the toxic and side effects of body or to gastrointestinal stimulate.
Embodiment is below used to describe embodiments of the present invention in detail, whereby to the present invention how application technology means
Solve technical problem, and the process that realizes reaching technique effect can fully understand and implement according to this.
The preparation of embodiment 1 decoction liquor 1
By Radix seu Herba Gei aleppici 50g, Rhizoma Panacis Japonici 45g, Fructus Psoraleae 55g, Rhizoma Atractylodis Macrocephalae 45g, Rhizoma Polygonati 50g, Radix Glehniae 45g, Fructus Lycii 40g,
Herba Visci 40g, Herb Gynostemmae Pentaphylli 35g and Xi 20g mix homogeneously, take mixture 100g and load in percolator, add the Chinese liquor of 55 DEG C
700g, soaks 25 hours under conditions of 30 DEG C, regulates percolator valve, makes Chinese liquor medicinal liquid slowly ooze, and it is every for oozing speed
Minute 3mL, collects drip, obtains the percolate of 700mL, concentrates, and removes Chinese liquor, dry, pulverize, it is thus achieved that the powder being dried, will
Radix Platycodonis 25g, Radix Phytolaccae 30g, Fructus Crataegi 25g, Rhizoma Dioscoreae 75g, Flos Lonicerae 30g, Caulis Sargentodoxae 25g, Fructus Cnidii 40g, Herba Artemisiae Annuae 20g, Cortex Cinnamomi
25g, Radix Angelicae Sinensis 35g, Radix Isatidis 25g, Radix Polygoni Multiflori 35g, Caulis Fibraureae 25g, Radix Glycyrrhizae 30g mix, and take 100g mixture, add 600g's
Water, boils 4 hours, filters, it is thus achieved that the first filtrate, and filtering residue adds the water of 200g again, again boils 2 hours, filters, it is thus achieved that the
Two filtrates, mix the first filtrate and the second filtrate, add the previously obtained powder being dried, and stirring to powder is completely dissolved,
Concentrating crude drug concentration is 1g/mL, it is thus achieved that decoction liquor 1.
Embodiment 2 toxicological experiment
Acute toxicity testing
Select Kunming mouse 20, female half and half, body weight (20+2) g, Qingdao City's Experimental Animal Center provide, will be real
The decoction liquor executing example 1 preparation gavages mice, through preliminary experiment, fails to detect the LD of oral administration50, therefore survey its maximum tolerance
Amount, with the administration volume of 1.4ml/10g body weight, gavages 2 times/d, is spaced 6h, secondary to observation post administration 7d, record animal dead and poison
Reaction symptom, at the end of experiment, processes all animals, dissects, perusal each main organs lesion tissue situation, fills for 2 times
After taking 140g crude drug/kg, animal activity, feed water inlet does not shows any abnormalities, and observes 7d animal dead, and gross necropsy has no main
The obvious exception of organs and tissues, therefore, the maximum dosage-feeding of Chinese medicine granules is > 140g crude drug/kg, this dosage is equivalent to clinic
70 times of adult (based on 60kg) maximum every day oral dose 2g crude drug/kg.
Long term toxicity test
Select 40 male SD rats, weight (180 ± 20) g, Qingdao City's Experimental Animal Center provide, be randomly divided into
2 groups, blank group and Chinese drug-treated group, often group 20, blank group gives distilled water, and what embodiment 1 was prepared by Chinese drug-treated group decocts
Boiling liquid 1, gavage rat, the amount of gavaging is 50g crude drug/kg, on every Mondays to gastric infusion in morning Saturday 1 time, and continuous 180d, it is administered body
Amassing as 2mL/100g body weight, every day observes rat general state, sign, food ration, drinking-water and feces before being administered and during being administered
Situation.During administration 90d after last is administered 24h, each group extraction 6, male and female half and half；After during 180d, last is administered 24h, take out for each group
Take 6, male and female half and half；After drug withdrawal, 30d respectively organizes extraction 6, male and female half and half, anaesthetizes with urethane, takes blood from abdominal aortic, respectively
Group is all killed and is taken animal, checks hematology and blood parameters, after taking blood, amass wealth by heavy taxation at once core, liver,kidney,spleen, lung, adrenal gland, first
The internal organs such as shape gland, thymus, testis, ovary, uterus, brain, prostate are weighed, according to weight calculator official's weight coefficient and make pathology
Learn and check.
On inspection, during successive administration, the activity of animal, body weight, food ration, stool and hair luster degree have no different
Often, animal has no dead, and naked eyes have no obvious pathological changes, and each group rat peripheral hemogram checking is all in normal range, and the raw tea of blood refers to
Mark is all in normal range, and Chinese drug-treated group Rats Organs and Tissues coefficient is not significantly different from compared with blank group.
From embodiment 2 it can be seen that the Chinese medicine composition Clinical practice of the present invention is safe.
The preparation of embodiment 3 decoction liquor 2
By Radix seu Herba Gei aleppici 45g, Rhizoma Panacis Japonici 40g, Fructus Psoraleae 50g, Rhizoma Atractylodis Macrocephalae 40g, Rhizoma Polygonati 45g, Radix Glehniae 40g, Fructus Lycii 35g,
Herba Visci 35g, Herb Gynostemmae Pentaphylli 30g and Xi 15g mix homogeneously, take mixture 100g and load in percolator, add the Chinese liquor of 55 DEG C
700g, soaks 25 hours under conditions of 30 DEG C, regulates percolator valve, makes Chinese liquor medicinal liquid slowly ooze, and it is every for oozing speed
Minute 3mL, collects drip, obtains the percolate of 700mL, concentrates, and removes Chinese liquor, dry, pulverize, it is thus achieved that the powder being dried, will
Radix Platycodonis 20g, Radix Phytolaccae 25g, Fructus Crataegi 20g, Rhizoma Dioscoreae 70g, Flos Lonicerae 25g, Caulis Sargentodoxae 20g, Fructus Cnidii 35g, Herba Artemisiae Annuae 15g, Cortex Cinnamomi
20g, Radix Angelicae Sinensis 30g, Radix Isatidis 20g, Radix Polygoni Multiflori 30g, Caulis Fibraureae 20g, Radix Glycyrrhizae 25g mix, and take 100g mixture, add 600g's
Water, boils 4 hours, filters, it is thus achieved that the first filtrate, and filtering residue adds the water of 200g again, again boils 2 hours, filters, it is thus achieved that the
Two filtrates, mix the first filtrate and the second filtrate, add the previously obtained powder being dried, and stirring to powder is completely dissolved,
Concentrating crude drug concentration is 1g/mL, it is thus achieved that decoction liquor 2.
The preparation of embodiment 4 decoction liquor 3
By Radix seu Herba Gei aleppici 55g, Rhizoma Panacis Japonici 50g, Fructus Psoraleae 60g, Rhizoma Atractylodis Macrocephalae 50g, Rhizoma Polygonati 55g, Radix Glehniae 50g, Fructus Lycii 45g,
Herba Visci 45g, Herb Gynostemmae Pentaphylli 40g and Xi 25g mix homogeneously, take mixture 100g and load in percolator, add the Chinese liquor of 55 DEG C
700g, soaks 25 hours under conditions of 30 DEG C, regulates percolator valve, makes Chinese liquor medicinal liquid slowly ooze, and it is every for oozing speed
Minute 3mL, collects drip, obtains the percolate of 700mL, concentrates, and removes Chinese liquor, dry, pulverize, it is thus achieved that the powder being dried, will
Radix Platycodonis 30g, Radix Phytolaccae 35g, Fructus Crataegi 30g, Rhizoma Dioscoreae 80g, Flos Lonicerae 35g, Caulis Sargentodoxae 30g, Fructus Cnidii 45g, Herba Artemisiae Annuae 25g, Cortex Cinnamomi
30g, Radix Angelicae Sinensis 40g, Radix Isatidis 30g, Radix Polygoni Multiflori 40g, Caulis Fibraureae 30g, Radix Glycyrrhizae 35g mix, and take 100g mixture, add 600g's
Water, boils 4 hours, filters, it is thus achieved that the first filtrate, and filtering residue adds the water of 200g again, again boils 2 hours, filters, it is thus achieved that the
Two filtrates, mix the first filtrate and the second filtrate, add the previously obtained powder being dried, and stirring to powder is completely dissolved,
Concentrating crude drug concentration is 1g/mL, it is thus achieved that decoction liquor 3.
The preparation of embodiment 5 injection 1
By Radix seu Herba Gei aleppici 50g, Rhizoma Panacis Japonici 45g, Fructus Psoraleae 55g, Rhizoma Atractylodis Macrocephalae 45g, Rhizoma Polygonati 50g, Radix Glehniae 45g, Fructus Lycii 40g,
Herba Visci 40g, Herb Gynostemmae Pentaphylli 35g and Xi 20g mix homogeneously, take mixture 100g and load in percolator, add the Chinese liquor of 55 DEG C
700g, soaks 25 hours under conditions of 30 DEG C, regulates percolator valve, makes Chinese liquor medicinal liquid slowly ooze, and it is every for oozing speed
Minute 3mL, collects drip, obtains the percolate of 700mL, concentrates, and removes Chinese liquor, dry, pulverize, it is thus achieved that the powder being dried, will
Radix Platycodonis 25g, Radix Phytolaccae 30g, Fructus Crataegi 25g, Rhizoma Dioscoreae 75g, Flos Lonicerae 30g, Caulis Sargentodoxae 25g, Fructus Cnidii 40g, Herba Artemisiae Annuae 20g, Cortex Cinnamomi
25g, Radix Angelicae Sinensis 35g, Radix Isatidis 25g, Radix Polygoni Multiflori 35g, Caulis Fibraureae 25g, Radix Glycyrrhizae 30g mix, and take 100g mixture, add 600g's
Water, boils 4 hours, filters, it is thus achieved that the first filtrate, and filtering residue adds the water of 200g again, again boils 2 hours, filters, it is thus achieved that the
Two filtrates, mix the first filtrate and the second filtrate, add the previously obtained powder being dried, and stirring to powder is completely dissolved,
Concentrating, remove part water, the volume to solution is 100mL, cold preservation at a temperature of 0 DEG C, filters, and filtrate adds the work of 10%
Property carbon decoloring, Ex-all activated carbon, with 10% sodium hydroxide solution regulation pH value to 7, embedding, sterilizing, obtain injection 1.
The preparation of embodiment 6 Chinese medicine composition feed additive powder
By Radix seu Herba Gei aleppici 50g, Rhizoma Panacis Japonici 45g, Fructus Psoraleae 55g, Rhizoma Atractylodis Macrocephalae 45g, Rhizoma Polygonati 50g, Radix Glehniae 45g, Fructus Lycii 40g,
Herba Visci 40g, Herb Gynostemmae Pentaphylli 35g and Xi 20g mix homogeneously, take mixture 100g and load in percolator, add the Chinese liquor of 55 DEG C
700g, soaks 25 hours under conditions of 30 DEG C, regulates percolator valve, makes Chinese liquor medicinal liquid slowly ooze, and it is every for oozing speed
Minute 3mL, collects drip, obtains the percolate of 700mL, concentrates, and removes Chinese liquor, dry, pulverize, it is thus achieved that the first powder being dried
End, by Radix Platycodonis 25g, Radix Phytolaccae 30g, Fructus Crataegi 25g, Rhizoma Dioscoreae 75g, Flos Lonicerae 30g, Caulis Sargentodoxae 25g, Fructus Cnidii 40g, Herba Artemisiae Annuae 20g, meat
Osmanthus 25g, Radix Angelicae Sinensis 35g, Radix Isatidis 25g, Radix Polygoni Multiflori 35g, Caulis Fibraureae 25g, Radix Glycyrrhizae 30g mix, and take 100g mixture, add 600g's
Water, boils 4 hours, filters, it is thus achieved that the first filtrate, and filtering residue adds the water of 200g again, again boils 2 hours, filters, it is thus achieved that the
Two filtrates, mix the first filtrate and the second filtrate, concentrate and remove water, it is thus achieved that the second dry powder, by the first powder and the
Two powder mixing, it is thus achieved that feed additive powder.
The concrete preparation of embodiment 7 feedstuff
Feed additive powder 160g embodiment 5 prepared is mixed in the Semen Tritici aestivi of 1kg, it is thus achieved that feedstuff.
Embodiment 8 raises data
Laboratory animal
Healthy broiler chicks 260,1 age in days, purchased from chicken farm, Qingdao, average weight 68.5g, it is divided into 2 groups: medium-height grass
Group and matched group.
Feeding method
The decoction liquor 1 of the Chinese drug-treated group gavage every day embodiment of the present invention 1 preparation, gavages 3 times, each 30mL, matched group every day
Add cleaning drinking-water.Two groups all carry out conventional feeding and management and daily immunity.
Test method
Weightening finish
Each group all inoculates newcastle VI system attenuated vaccine in 10 ages in days, purchased from the big magnificent limited public affairs of agriculture animal health-care product in Guangdong
Department, takes 10 at random in 20 and 40 ages in days are each, weighs respectively.
The detection of part normal blood index
The indexs such as RBC (erythrocyte), WBC (leukocyte), LYM (lymphocyte), HGB (content of hemoglobin) all use U.S.
State QBC-R routine blood test analyzer is measured.Application Excel software carries out t check analysis to data above.
The detection of immunologic function
Detection NDV HI antibody, immune organ of weighing (spleen, fabricius bursa and thymus) as follows Computation immunity device
Official's index: Immune Organs Index=immune organ weight in wet base/body weight × 100.Pass through C3B receptor rosette formation test, detects erythrocytic glutinous
Attached property.
NDV antibody titer
Often organize and choose 10 respectively, vein or Culling heart blood under the wing, separate serum, each with hemagglutination inhibition test (HI) detection
Group NDV serum antibody titer, calculates each group of Mean antibody titers.
Result
The change of two groups of broiler weights, the results are shown in Table 1.
The change (g) of 1 liang of table group broiler weight
As it can be seen from table 1 compared with matched group, use the Chinese traditional immunopoteniators decoction liquor of the present invention significantly to carry
The growth body weight of high broiler chicks, P < 0.05, there is comparability.
The change of NDV antibody titer, the results are shown in Table 2.
The group broiler chicks serum N DV antibody titer change of 2 liang of table
From table 2 it can be seen that use the Chinese traditional immunopoteniators of the present invention, in feeding process, serum N DV of broiler chicks
Antibody titer relatively matched group increases notable, and P < 0.05 has comparability.
The change of two groups of broiler chicks RBC aging, the results are shown in Table 3.
The change (%) of 3 liang of table group broiler chicks RBC aging
From table 3 it can be seen that relative to matched group, use the Chinese traditional immunopoteniators of the present invention, in feeding process, meat
It is more that the RBC aging of chickling increases, and P < 0.05 has comparability, it was demonstrated that the Chinese traditional immunopoteniators of the present invention
Erythrocytic immunologic function can be strengthened.
The change of Immune Organs Index, the results are shown in Table 4.
The change of the Immune Organs Index of 4 liang of table group broiler chicks
From table 4, it can be seen that use, the Chinese traditional immunopoteniators of the present invention can dramatically increase index and spleen index, fabricius bursa refers to
Number and thymus index.
The change of two groups of broiler chicks blood routine biochemical indicators, the results are shown in Table 5 and table 6.
5 liang of table group broiler chicks lymphocyte number and the change of hemoglobin number
6 liang of table group broiler chicks RBC number and the change of leukocyte count
All above-mentioned primary these intellectual properties of enforcement, do not set this new product of enforcement limiting other forms
And/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar execution feelings
Condition.But, all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, appoints
What those skilled in the art changed possibly also with the technology contents of the disclosure above or be modified as equivalent variations etc.
Effect embodiment.But every without departing from technical solution of the present invention content, the technical spirit of the foundation present invention is to above example institute
Any simple modification, equivalent variations and the remodeling made, still falls within the protection domain of technical solution of the present invention.
Claims (9)
1. the Chinese traditional immunopoteniators being used for improving broiler immunologic function in growth course, it is characterised in that: described
The crude drug of Chinese traditional immunopoteniators is by Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Radix Platycodonis, Radix Phytolaccae, Fructus Psoraleae, Fructus Crataegi, Rhizoma Dioscoreae, Flos Lonicerae, big blood
Rattan, Fructus Cnidii, Herba Artemisiae Annuae, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Rhizoma Polygonati, Fructus Lycii, Radix Glehniae, Radix Angelicae Sinensis, Radix Isatidis, Herba Visci, Radix Polygoni Multiflori, Caulis Fibraureae, Xi
, Herb Gynostemmae Pentaphylli and Radix Glycyrrhizae constitute；
In described Chinese traditional immunopoteniators, the weight portion of each crude drug is respectively Radix seu Herba Gei aleppici 45～55 weight portion, Rhizoma Panacis Japonici 40～50
Weight portion, Radix Platycodonis 20～30 weight portion, Radix Phytolaccae 25～35 weight portion, Fructus Psoraleae 50～60 weight portion, Fructus Crataegi 20～30 weight portion,
Rhizoma Dioscoreae 70～80 weight portion, Flos Lonicerae 25～35 weight portion, Caulis Sargentodoxae 20～30 weight portion, Fructus Cnidii 35～45 weight portion, green grass or young crops
Artemisia 15～25 weight portion, the Rhizoma Atractylodis Macrocephalae 40～50 weight portion, Cortex Cinnamomi 20～30 weight portion, Rhizoma Polygonati 45～55 weight portion, Fructus Lycii 35～
45 weight portions, Radix Glehniae 40～50 weight portion, Radix Angelicae Sinensis 30～40 weight portion, Radix Isatidis 20～30 weight portion, Herba Visci 35～45
Weight portion, Radix Polygoni Multiflori 30～40 weight portion, Caulis Fibraureae 20～30 weight portion, Xi 15～25 weight portion, Herb Gynostemmae Pentaphylli 30～40 weight
Part and Radix Glycyrrhizae 25～35 weight portion.
2. Chinese traditional immunopoteniators as claimed in claim 1, it is characterised in that: each crude drug in described Chinese traditional immunopoteniators
Weight portion be respectively Radix seu Herba Gei aleppici 50 weight portion, Rhizoma Panacis Japonici 45 weight portion, Radix Platycodonis 25 weight portion, Radix Phytolaccae 30 weight portion, Fructus Psoraleae
55 weight portions, Fructus Crataegi 25 weight portion, Rhizoma Dioscoreae 75 weight portion, Flos Lonicerae 30 weight portion, Caulis Sargentodoxae 25 weight portion, Fructus Cnidii 40 weight
Part, Herba Artemisiae Annuae 20 weight portion, the Rhizoma Atractylodis Macrocephalae 45 weight portion, Cortex Cinnamomi 25 weight portion, Rhizoma Polygonati 50 weight portion, Fructus Lycii 40 weight portion, Radix Glehniae
45 weight portions, Radix Angelicae Sinensis 35 weight portion, Radix Isatidis 25 weight portion, Herba Visci 40 weight portion, Radix Polygoni Multiflori 35 weight portion, Caulis Fibraureae 25 weight
Part, Xi 20 weight portion, Herb Gynostemmae Pentaphylli 35 weight portion and Radix Glycyrrhizae 30 weight portion.
3. the preparation method of the Chinese traditional immunopoteniators described in claim 1 or 2, it is characterised in that: described Chinese medicine immunostimulant
The dosage form of agent is injection, and described method includes,
The first step, by Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Radix Glehniae, Fructus Lycii, Herba Visci, Herb Gynostemmae Pentaphylli and Xi
It is mixed in proportion, takes mixture 100g and load in percolator, add Chinese liquor 600g～800g of 50 DEG C～55 DEG C, at 25 DEG C～35
Soak 20 hours～30 hours under conditions of DEG C, regulate percolator valve, make Chinese liquor medicinal liquid slowly ooze, ooze speed and be every point
Clock 2～4mL, collects drip, obtains the percolate of 700mL～1L, concentrates, and removes Chinese liquor, dry, pulverize, it is thus achieved that the powder being dried
End；
Second step, by Radix Platycodonis, Radix Phytolaccae, Fructus Crataegi, Rhizoma Dioscoreae, Flos Lonicerae, Caulis Sargentodoxae, Fructus Cnidii, Herba Artemisiae Annuae, Cortex Cinnamomi, Radix Angelicae Sinensis, Radix Isatidis,
Radix Polygoni Multiflori, Caulis Fibraureae and Radix Glycyrrhizae are mixed in proportion, and take 100g mixture, add the water of 500g～800g, boil 3～4 hours, mistake
Filter, it is thus achieved that the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filters, it is thus achieved that the second filter
Liquid, mixes the first filtrate and the second filtrate, adds the powder being dried that the first step obtains, and stirring to powder is completely dissolved, dense
Contracting, removes part water, and the volume to solution is 100mL, cold preservation at a temperature of 0 DEG C, filters, and filtrate adds the activity of 10%
Carbon decoloring, Ex-all activated carbon, with 10% sodium hydroxide solution regulation pH value to 6.5～7.5, embedding, sterilizing, obtain injection.
4. the preparation method of the Chinese traditional immunopoteniators described in claim 1 or 2, it is characterised in that: described Chinese medicine immunostimulant
The dosage form of agent is decoction liquor, and described method includes,
The first step, by Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Radix Glehniae, Fructus Lycii, Herba Visci, Herb Gynostemmae Pentaphylli and Xi
It is mixed in proportion, takes mixture 100g and load in percolator, add Chinese liquor 600g～800g of 50 DEG C～55 DEG C, at 25 DEG C～35
Soak 20 hours～30 hours under conditions of DEG C, regulate percolator valve, make Chinese liquor medicinal liquid slowly ooze, ooze speed and be every point
Clock 2～4mL, collects drip, obtains the percolate of 700mL～1L, concentrates, and removes Chinese liquor, dry, pulverize, it is thus achieved that the powder being dried
End；
Second step, by Radix Platycodonis, Radix Phytolaccae, Fructus Crataegi, Rhizoma Dioscoreae, Flos Lonicerae, Caulis Sargentodoxae, Fructus Cnidii, Herba Artemisiae Annuae, Cortex Cinnamomi, Radix Angelicae Sinensis, Radix Isatidis,
Radix Polygoni Multiflori, Caulis Fibraureae and Radix Glycyrrhizae are mixed in proportion, and take 100g mixture, add the water of 500g～800g, boil 3～4 hours, mistake
Filter, it is thus achieved that the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filters, it is thus achieved that the second filter
Liquid, mixes the first filtrate and the second filtrate, adds the powder being dried that the first step obtains, and stirring to powder is completely dissolved, dense
Contracting crude drug concentration is 1g/mL, it is thus achieved that decoction liquor.
5. the preparation method of the Chinese traditional immunopoteniators described in claim 1 or 2, it is characterised in that: described Chinese medicine immunostimulant
Agent for feed additive powder, described method includes,
The first step, by Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Radix Glehniae, Fructus Lycii, Herba Visci, Herb Gynostemmae Pentaphylli and Xi
It is mixed in proportion, takes mixture 100g and load in percolator, add Chinese liquor 600g～800g of 50 DEG C～55 DEG C, at 25 DEG C～35
Soak 20 hours～30 hours under conditions of DEG C, regulate percolator valve, make Chinese liquor medicinal liquid slowly ooze, ooze speed and be every point
Clock 2～4mL, collects drip, obtains the percolate of 700mL～1L, concentrates, and removes Chinese liquor, dry, pulverize, it is thus achieved that the be dried
One powder；
Second step, by Radix Platycodonis, Radix Phytolaccae, Fructus Crataegi, Rhizoma Dioscoreae, Flos Lonicerae, Caulis Sargentodoxae, Fructus Cnidii, Herba Artemisiae Annuae, Cortex Cinnamomi, Radix Angelicae Sinensis, Radix Isatidis,
Radix Polygoni Multiflori, Caulis Fibraureae and Radix Glycyrrhizae are mixed in proportion, and take 100g mixture, add the water of 500g～800g, boil 3～4 hours, mistake
Filter, it is thus achieved that the first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filters, it is thus achieved that the second filter
Liquid, mixes the first filtrate and the second filtrate, concentrates and remove water, it is thus achieved that the second dry powder, by the first powder and the second powder
End mixing, it is thus achieved that feed additive powder.
6. the Chinese medicine feed additive being used for improving broiler immunologic function in growth course, it is characterised in that: described
The crude drug of Chinese medicine feed additive is by Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Radix Platycodonis, Radix Phytolaccae, Fructus Psoraleae, Fructus Crataegi, Rhizoma Dioscoreae, Flos Lonicerae, big blood
Rattan, Fructus Cnidii, Herba Artemisiae Annuae, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Rhizoma Polygonati, Fructus Lycii, Radix Glehniae, Radix Angelicae Sinensis, Radix Isatidis, Herba Visci, Radix Polygoni Multiflori, Caulis Fibraureae, Xi
, Herb Gynostemmae Pentaphylli and Radix Glycyrrhizae constitute；
In described Chinese medicine feed additive, the weight portion of each crude drug is respectively Radix seu Herba Gei aleppici 45～55 weight portion, Rhizoma Panacis Japonici 40～50
Weight portion, Radix Platycodonis 20～30 weight portion, Radix Phytolaccae 25～35 weight portion, Fructus Psoraleae 50～60 weight portion, Fructus Crataegi 20～30 weight portion,
Rhizoma Dioscoreae 70～80 weight portion, Flos Lonicerae 25～35 weight portion, Caulis Sargentodoxae 20～30 weight portion, Fructus Cnidii 35～45 weight portion, green grass or young crops
Artemisia 15～25 weight portion, the Rhizoma Atractylodis Macrocephalae 40～50 weight portion, Cortex Cinnamomi 20～30 weight portion, Rhizoma Polygonati 45～55 weight portion, Fructus Lycii 35～
45 weight portions, Radix Glehniae 40～50 weight portion, Radix Angelicae Sinensis 30～40 weight portion, Radix Isatidis 20～30 weight portion, Herba Visci 35～45
Weight portion, Radix Polygoni Multiflori 30～40 weight portion, Caulis Fibraureae 20～30 weight portion, Xi 15～25 weight portion, Herb Gynostemmae Pentaphylli 30～40 weight
Part and Radix Glycyrrhizae 25～35 weight portion.
7. a feedstuff, it is characterised in that: stated the feed additive described in 6 by main feed and claim, constitute, relative to
The main feed of 100 weight portions, the addition of described feed additive is 15 weight portions～18 weight portions.
8. feedstuff as claimed in claim 7, it is characterised in that: described main feed is Fructus Hordei Vulgaris, Semen Tritici aestivi, Semen Maydis.
9. the preparation method of feedstuff described in claim 7 or 8, it is characterised in that including:
The first step, by Radix seu Herba Gei aleppici, Rhizoma Panacis Japonici, Fructus Psoraleae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati, Radix Glehniae, Fructus Lycii, Herba Visci, Herb Gynostemmae Pentaphylli and Xi
It is mixed in proportion, takes mixture 100g and load in percolator, add Chinese liquor 600g～800g of 50 DEG C～55 DEG C, at 25 DEG C～35
Soak 20 hours～30 hours under conditions of DEG C, regulate percolator valve, make Chinese liquor medicinal liquid slowly ooze, ooze speed and be every point
Clock 2～4mL, collects drip, obtains the percolate of 700mL～1L, concentrates, and removes Chinese liquor, dry, pulverize, it is thus achieved that the be dried
One powder；By Radix Platycodonis, Radix Phytolaccae, Fructus Crataegi, Rhizoma Dioscoreae, Flos Lonicerae, Caulis Sargentodoxae, Fructus Cnidii, Herba Artemisiae Annuae, Cortex Cinnamomi, Radix Angelicae Sinensis, Radix Isatidis, He Shou
Crow, Caulis Fibraureae and Radix Glycyrrhizae are mixed in proportion, and take 100g mixture, add the water of 500g～800g, boil 3～4 hours, filter, obtain
The first filtrate, filtering residue adds the water of 200g～300g again, again boils 1～2 hour, filters, it is thus achieved that the second filtrate, by the
One filtrate and the mixing of the second filtrate, concentrate and remove water, it is thus achieved that the second dry powder, the first powder and the second powder is mixed,
Obtain feed additive powder；
Second step, is mixed in main feed in proportion by above-mentioned feed additive powder.
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| CN104054975B (en) * | 2014-07-16 | 2015-10-21 | 黄荣波 | A kind of growth promoting effects, the chicken feed improving disease resistance, improve meat |
| CN104171598A (en) * | 2014-07-16 | 2014-12-03 | 郑志保 | Chicken feed capable of promoting growth and improving disease resistance and meat quality |
| CN104489320A (en) * | 2014-12-08 | 2015-04-08 | 安徽威格尔牧业科技有限公司 | Special digestion promoting feed for SPF chicken in brooding period |
| CN105053632A (en) * | 2015-07-31 | 2015-11-18 | 无为县金宝生态农业开发有限公司 | Feed for improving quality of chicken of fryers |
| CN105192426A (en) * | 2015-10-27 | 2015-12-30 | 王维维 | Chicken feed additive for enhancing immunity and preparation method thereof |
| CN106472853A (en) * | 2016-09-30 | 2017-03-08 | 安徽华澳生物技术有限公司 | The broiler fodder that a kind of plant material is prepared |
| CN106511758A (en) * | 2016-11-18 | 2017-03-22 | 河南惠通天下生物工程有限公司 | Traditional Chinese veterinary medicine composition for enhancing immunity and preparation method thereof |
| CN111345405A (en) * | 2020-03-12 | 2020-06-30 | 广西壮族自治区林业科学研究院 | Biological feed additive containing cinnamon residues and cajeput residues and preparation method thereof |
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| CN101537063A (en) * | 2009-04-14 | 2009-09-23 | 马晓海 | Formulation method for treating chicken dysentery and toxic heat |
| CN103110023A (en) * | 2013-03-12 | 2013-05-22 | 山东春雪药业有限公司 | Feed Chinese herbal medicine additive for improving broiler chicken immunity and production method thereof |
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| CN101537063A (en) * | 2009-04-14 | 2009-09-23 | 马晓海 | Formulation method for treating chicken dysentery and toxic heat |
| CN103110023A (en) * | 2013-03-12 | 2013-05-22 | 山东春雪药业有限公司 | Feed Chinese herbal medicine additive for improving broiler chicken immunity and production method thereof |
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