CN104436033A - Chinese medicinal composition for treating abdominal incisional hernia and preparation method thereof - Google Patents

Chinese medicinal composition for treating abdominal incisional hernia and preparation method thereof Download PDF

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CN104436033A
CN104436033A CN201410653666.7A CN201410653666A CN104436033A CN 104436033 A CN104436033 A CN 104436033A CN 201410653666 A CN201410653666 A CN 201410653666A CN 104436033 A CN104436033 A CN 104436033A
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radix
chinese medicine
medicine composition
fructus
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崔合芳
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Abstract

The invention discloses a Chinese medicinal composition for treating abdominal incisional hernia and a preparation method thereof. The Chinese medicinal composition is prepared from 17 types of Chinese medicinal materials including Szechwan chinaberry fruit, tangerine seeds, litchi seeds, haw, lindera aggregata, astragalus root, angelica, yam, zedoary, sculellaria barbata, costus root, myrrh, salvia miltiorrhiza, poria cocos, trogopterus dung, red bean and licorice by a pharmaceutical process. The Chinese medicinal composition has a significant treatment effect on the abdominal incisional hernia, and the preparation method is simple and convenient in preparation process, strong in universality and easy to popularize and apply.

Description

A kind of Chinese medicine composition for the treatment of Abdominal Incisional Hernia and preparation method thereof
Technical field
The invention belongs to tcm field, be specifically related to a kind of Chinese medicine composition for the treatment of Abdominal Incisional Hernia and preparation method thereof.
Technical background
Abdominal Incisional Hernia is the hernia that in abdomen, internal organs or tissue are given prominence to through incision of abdominal wall, and when main manifestations is for standing, incision has hernia block to give prominence to, cough or more obvious when exerting oneself; Usual hernia ring is comparatively large, flat sleeping after hernia block namely return voluntarily and receive disappearance; As hernia block has more greatly comparatively multi viscera and tissue to give prominence to, abdominal part dull pain can be had, involve the discomforts such as tenesmus.
Infection of incisional wound is the topmost cause of disease of incisional hernia, and incision for secondary healing after infecting, scar tissue is many, and stomach wall has defect in various degree, and cutting part stomach wall intensity obviously reduces.According to statistics, after infection of incisional wound, the incidence rate of incisional hernia is 5 ~ 10 times of primary healing otch, and in addition, stomach wall is weak or suffer from the chronic disease that intra-abdominal pressure is increased and easily bring out incisional hernia, therefore is more common in old or obese patient.Therefore, Incision infection prevention, reinforcement exercise, powerful physique are the most important measure reducing incisional hernia incidence rate.
At present, clinical treatment Abdominal Incisional Hernia is based on operative treatment, but to getting old and weak and having the chronic disease person making intra-abdominal pressure increase, should not perform the operation, and hernial content often outstanding stomach wall defect and with stomach wall shallow layer tissue, even with skin adhesion, the careless slightly internal organs just accidentally injuring adhesion, operating difficulty is larger.
The present invention is theoretical according to Chinese medical discrimination, in conjunction with clinical practice, repeatedly gropes practice, finally show that one has the Chinese prescription of good efficacy to Abdominal Incisional Hernia.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition Abdominal Incisional Hernia being had to better therapeutic effect, and optimized fabrication technique, be made into that universality is strong, drug effect is significantly stablized, be easy to carry about with one the Chinese medicine preparation taken.
In order to realize object of the present invention, Chinese medicine composition of the present invention is made up of the raw material of following weight portion:
Fructus Toosendan 5-15 part, Fructus Citri tangerinae core 10-20 part, Semen Litchi 10-20 part, Fructus Crataegi 20-30 part, Radix Linderae 5-15 part, Radix Astragali 3-8 part, Radix Angelicae Sinensis 5-10 part, Rhizoma Dioscoreae 10-20 part, Rhizoma Curcumae 5-15 part, Herba Scutellariae Barbatae 10-20 part, Radix Aucklandiae 5-15 part, Myrrha 5-10 part, Radix Salviae Miltiorrhizae 5-15 part, Poria 10-20 part, Oletum Trogopterori 3-8 part, Semen Phaseoli 10-30 part, Radix Glycyrrhizae 10-30 part.
Preferred Chinese medicine composition of the present invention is made up of the raw material of following weight portion:
Fructus Toosendan 10 parts, Fructus Citri tangerinae core 15 parts, Semen Litchi 15 parts, Fructus Crataegi 25 parts, the Radix Linderae 9 parts, the Radix Astragali 5 parts, Radix Angelicae Sinensis 8 parts, Rhizoma Dioscoreae 15 parts, Rhizoma Curcumae 13 parts, Herba Scutellariae Barbatae 15 parts, the Radix Aucklandiae 13 parts, Myrrha 8 parts, Radix Salviae Miltiorrhizae 10 parts, 15 parts, Poria, Oletum Trogopterori 5 parts, Semen Phaseoli 20 parts, 20 parts, Radix Glycyrrhizae.
The preparation technology of Chinese medicine composition of the present invention is following steps:
Step 1, take Fructus Toosendan, the Radix Linderae, Fructus Citri tangerinae core, Semen Litchi, the Radix Aucklandiae, Radix Angelicae Sinensis 6 taste medical material by Chinese prescription of the present invention, pulverize respectively, mixing, adds the ethanol of the 50-65% of 5-9 times of weight, reflux 2-3 hour, filters; Filtering residue adds the ethanol of the 50-65% of 4-6 times of initial medical material weight, and reflux 1-2 hour filters; By twice filtrate mixing, distilling under reduced pressure removing ethanol, obtains extracting solution 1, for subsequent use;
Step 2, take the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Curcumae, Herba Scutellariae Barbatae, Fructus Crataegi, Myrrha, Radix Salviae Miltiorrhizae, Poria, Oletum Trogopterori, Semen Phaseoli, Radix Glycyrrhizae 11 taste medical material by Chinese prescription of the present invention, pulverize respectively, mixing, adds the purified water of 6-10 times of medical material weight, backflow decocts 1-3 hour, filters; Filtering residue adds the purified water of 4-8 times of initial medical material weight, and backflow decocts 1-2 hour, filters, and twice filtrate mixed, 1/4 of simmer down to original volume, is extracting solution 2;
Step 3, by extracting solution 1,2 mix, being concentrated into density is 1.20-1.36(70-80 DEG C of survey), be Chinese medical concrete;
Step 4, Chinese medical concrete is added adjuvant make finished product Chinese medicine preparation.
Preferred Chinese medicine preparation of the present invention is capsule, tablet or honey pill agent.
Source and the function of the present invention's Chinese crude drug used cure mainly:
Fructus Toosendan: soothing liver-QI circulation of qi promoting, pain relieving, parasite killing, treats tinea.Cure mainly the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation, controls tinea capitis.Select the fruit of the drying and ripening of Meliaceae plant Fructus Toosendan.
The Radix Astragali: there is invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst.Select the dry root of leguminous plant Radix Astagali or Radix Astragali.
Fructus Crataegi: sour in the mouth is warm in nature, QI and blood is also walked, blood stasis dispelling and do not hinder fresh blood, the stagnant gas of row and do not hinder healthy energy, is applied to meat stagnation card, the stagnant stomachache chest pain of dysentery stomachache, colicky, the stasis of blood, lochiorrhea, dysmenorrhea, spits blood, has blood in stool.Modern alone this product preparation for treating cardiovascular disease, bacillary dysentery etc., all have good therapeutic effect, have blood fat reducing, blood pressure lowering, anti-brain blood and mechanism of action thereof.
Radix Angelicae Sinensis: hematonic; Enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation, cure mainly all cards of blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.Select the dry root of umbelliferae angelica.
Rhizoma Dioscoreae: spleen invigorating, tonifying the lung, reinforces the kidney, benefit essence.Control diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to consumptive disease, quench one's thirst, seminal emission, leukorrhagia, frequent micturition.Select the tuber of Dioscoreaceae plant Rhizoma Dioscoreae.
Fructus Citri tangerinae core: regulate the flow of vital energy, eliminating stagnation, pain relieving.For inguinal hernia, painful and swollen testis, acute mastitis swells and ache.Select the seed of rutaceae orange and variety thereof.
Semen Litchi: promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving.Cure mainly colic of cold type stomachache, painful and swollen testis.Select the dry mature fruit of sapindaceous plant Fructus Litchi.
The Radix Aucklandiae: promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.Cure mainly breast gastral cavity distending pain, heavy after dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).Be used for the treatment of stomachache of having loose bowels.Select the dry root of feverfew Saussurea lappa Clarke, Radix Vladimiriae.
The Radix Linderae: pleasant pain relieving, warming kidney for dispelling cold.Cure mainly chest and abdomen swelling and pain, QI rising in reverse order dyspnea with rapid respiration, deficiency-cold in the urinary bladder, enuresis frequent micturition, hernia, dysmenorrhea.Select the dry root of the canella Radix Linderae.
Herba Scutellariae Barbatae: the hemostasis of heat-clearing and toxic substances removing, dissipating blood stasis, inducing diuresis to remove edema.Cure mainly pyretic toxicity carbuncle, have sore throat, lung abscess, acute appendicitis, scrofula, venom, traumatic injury, haematemesis, epistaxis, stranguria with blood, edema, ascites and cancer.Select the dry herb of labiate Herba Scutellariae Barbatae.
Rhizoma Curcumae: circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.Amenorrhea due to stagnation of blood stomachache, abdominal mass can be treated, gather.The dry rhizome of menu cotyledon plant Zingiberaceae Rhizoma Curcumae or RADIX CURCUMAE (also known as Curcuma wenyujin).
Myrrha: loose blood and relieving pain, detumescence and promoting granulation.Cure mainly ulcer sore pain, trusted subordinate, all pains of muscles and bones, traumatic blood stasis, external can expelling pus and promoting granulation.Select the dry resin of olive subject plant myrrh or Alan fort Myrrha.
Radix Salviae Miltiorrhizae: blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle, nourishing blood to tranquillize the mind.Cure mainly menoxenia, amenorrhea dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, heart dumpling pain.Select the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.
Poria: promoting diuresis to eliminate damp pathogen, spleen invigorating, calms the nerves.Cure mainly edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.Now also for the treatment of hysteromyoma.Select the dry sclerotia of On Polyporaceae Poria.
Oletum Trogopterori: promoting blood circulation and stopping pain, removing stasis to stop bleeding.Cure mainly breast the side of body, gastral cavity ventral spine pain, stimulate the menstrual flow, amenorrhea, puerperal blood stasis pain, tumbling and swelling, snake bite and insect sting.Select the dry feces of flying squirrel section animal trogopterus xanthipes Milne-Edwards.
Semen Phaseoli: inducing diuresis to remove edema, removing toxic substances and promoting pus discharge.Cure mainly edema distension, beriberi edema, jaundice dark coloured urine, beriberoid pyretic arthralgia.Select the dry mature fruit of leguminous plant Semen Phaseoli or Semen Phaseoli.
Radix Glycyrrhizae: raw with cooler, can eliminating fire and detoxication, relieving spasm to stop pain; Process with partially warm, can fall apart exterior cold, invigorating the spleen and replenishing QI.In addition, Radix Glycyrrhizae is also good at being in harmonious proportion the property of medicine, separates the poison of hundred medicines.Select the dry rhizome of glycyrrhizic legume.
The prescription analysis of Chinese medicine of the present invention:
Chinese prescription of the present invention be with Fructus Toosendan, Fructus Citri tangerinae core, Semen Litchi, Fructus Crataegi, the Radix Linderae for monarch drug, regulate the flow of vital energy, eliminating stagnation, pain relieving, promoting flow of QI and blood; With the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Rhizoma Curcumae, Herba Scutellariae Barbatae for ministerial drug, the hemostasis of heat-clearing and toxic substances removing, dissipating blood stasis, inducing diuresis to remove edema; With the Radix Aucklandiae, Myrrha, Radix Salviae Miltiorrhizae for adjuvant drug, blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle, nourishing blood to tranquillize the mind; With Poria, Oletum Trogopterori, Semen Phaseoli for making medicine, inducing diuresis to remove edema, removing toxic substances and promoting pus discharge; With Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, all medicine of monarch coordinates, and complementing each other can warming the meridian circulation of qi promoting, and reinforcing kidney and strengthening resistance, activating QI to promote diuresis, clearing heat and removing internal wetness, the aqueous vapor of logical liver,spleen,kidney, the liver soothing and the spleen invigorating lung qi dispersing, the kidney warming dehumidifies, thus shows significant therapeutic effect to Abdominal Incisional Hernia.
Compared with prior art, Chinese herbal medicine specimen of the present invention is double to be controlled, stable curative effect, individual variation are little, have no side effect, and makes the simple process of preparation, is easy to apply.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
Step 1, take Fructus Toosendan 1000g, Radix Linderae 900g, Fructus Citri tangerinae core 1500g, Semen Litchi 1500g, Radix Aucklandiae 1300g, Radix Angelicae Sinensis 800g, pulverize respectively, mixing, adds the ethanol of 60% of 6 times of weight, reflux 2.5 hours, filters; Filtering residue adds the ethanol of 60% of 5 times of initial medical material weight, reflux 1.5 hours, filters; By twice filtrate mixing, distilling under reduced pressure removing ethanol, obtains extracting solution 1, for subsequent use;
Step 2, take Radix Astragali 500g, Rhizoma Dioscoreae 1500g, Rhizoma Curcumae 1300g, Herba Scutellariae Barbatae 1500g, Fructus Crataegi 2500g, Myrrha 800g, Radix Salviae Miltiorrhizae 1000g, Poria 1500g, Oletum Trogopterori 500g, Semen Phaseoli 2000g, Radix Glycyrrhizae 2000g, pulverize respectively, mixing, add the purified water of 8 times of medical material weight, backflow decoction 2 hours, filters; Filtering residue adds the purified water of 6 times of initial medical material weight, and backflow decoction 1.5 hours, filters, and by twice filtrate mixing, 1/4 of simmer down to original volume, is extracting solution 2;
Step 3, by extracting solution 1,2 mix, being concentrated into density is 1.28(75 DEG C of survey), be Chinese medical concrete;
Step 4, by raw material of Chinese medicine powder add adjuvant make capsule, crude drug content is about 0.3g crude drug/capsules.
Embodiment 2
Step 1, take Fructus Toosendan 500g, Radix Linderae 500g, Fructus Citri tangerinae core 1000g, Semen Litchi 1000g, Radix Aucklandiae 500g, Radix Angelicae Sinensis 500g, pulverize respectively, mixing, adds the ethanol of 60% of 6 times of weight, reflux 2.5 hours, filters; Filtering residue adds the ethanol of 60% of 5 times of initial medical material weight, reflux 1.5 hours, filters; By twice filtrate mixing, distilling under reduced pressure removing ethanol, obtains extracting solution 1, for subsequent use;
Step 2, take Radix Astragali 300g, Rhizoma Dioscoreae 1000g, Rhizoma Curcumae 500g, Herba Scutellariae Barbatae 1000g, Fructus Crataegi 2000g, Myrrha 500g, Radix Salviae Miltiorrhizae 500g, Poria 1000g, Oletum Trogopterori 300g, Semen Phaseoli 1000g, Radix Glycyrrhizae 1000g, pulverize respectively, mixing, add the purified water of 8 times of medical material weight, backflow decoction 2 hours, filters; Filtering residue adds the purified water of 6 times of initial medical material weight, and backflow decoction 1.5 hours, filters, and by twice filtrate mixing, 1/4 of simmer down to original volume, is extracting solution 2;
Step 3, by extracting solution 1,2 mix, being concentrated into density is 1.28(75 DEG C of survey), be Chinese medical concrete;
Step 4, by raw material of Chinese medicine powder add adjuvant make capsule, crude drug content is about 0.3g crude drug/capsules.
Embodiment 3,
Step 1, take Fructus Toosendan 1500g, Radix Linderae 1500g, Fructus Citri tangerinae core 2000g, Semen Litchi 2000g, Radix Aucklandiae 1500g, Radix Angelicae Sinensis 1000g, pulverize respectively, mixing, adds the ethanol of 60% of 6 times of weight, reflux 2.5 hours, filters; Filtering residue adds the ethanol of 60% of 5 times of initial medical material weight, reflux 1.5 hours, filters; By twice filtrate mixing, distilling under reduced pressure removing ethanol, obtains extracting solution 1, for subsequent use;
Step 2, take Radix Astragali 800g, Rhizoma Dioscoreae 2000g, Rhizoma Curcumae 1500g, Herba Scutellariae Barbatae 2000g, Fructus Crataegi 3000g, Myrrha 1000g, Radix Salviae Miltiorrhizae 1500g, Poria 2000g, Oletum Trogopterori 800g, Semen Phaseoli 3000g, Radix Glycyrrhizae 3000g, pulverize respectively, mixing, add the purified water of 8 times of medical material weight, backflow decoction 2 hours, filters; Filtering residue adds the purified water of 6 times of initial medical material weight, and backflow decoction 1.5 hours, filters, and by twice filtrate mixing, 1/4 of simmer down to original volume, is extracting solution 2;
Step 3, by extracting solution 1,2 mix, being concentrated into density is 1.28(75 DEG C of survey), be Chinese medical concrete;
Step 4, by raw material of Chinese medicine powder add adjuvant make capsule, crude drug content is about 0.3g crude drug/capsules.
The animal toxicity test of embodiment 4, Chinese medicine capsules of the present invention
(1) acute toxicity test
1, test drug: Chinese medicine capsules obtained by the embodiment of the present invention 1, takes apart capsule, is modulated into pasty state by purified water.Test animal used: regular grade NIH mice, body weight 22g ± 5g, male and female half and half, female mice is all without pregnant.
2, result of the test:
Application mice carries out acute toxicity testing and shows: mouse stomach Chinese medicine of the present invention, under 693.3g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none is dead for mice, and overall health of patients, diet, takes the photograph water, urine and body weight and increase all normal.Result of the test shows: the maximum dosage-feeding of mouse stomach Chinese medicine of the present invention is 693.3g crude drug/kg/d(LD50 > 693.3g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.15g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4622 times of clinical patient.Point out this medicine acute toxicity extremely low, clinical drug safety.
(2) long term toxicity test
1, test material:
(1), animal: select adult healthy SD rat 120, original body mass 220 ± 13g, male and female half and half, female rats is all without pregnant.
(2), medicine: embodiment of the present invention 1-3 gained Chinese medicinal capsule, take capsule apart, add purified water and be modulated into scattered paste shape, per weight dosage is by 20 times of calculating (clinical application amount foundation Pharmacopoeia of the People's Republic of China version in 2010) of clinical application amount.
2, test method
(1) 120 SD rats are divided into 4 groups, often organize 30, male and female half and half.Experimental animal male and female sub-cage rearing, 5, every cage, quantitative feeding (every cage 1200-1500g/ week), normal feedstuff is experimental mouse full-valence pellet feed, freely drinks water.Experimental temperature (22 ± 2) DEG C, humidity 60%-80%.The natural lighting light and shade cycle.After SD rat is bought, under this laboratory rearing condition, adapt to 2 weeks, observe general behavior performance.Test pre-test animal ingestion amount, selects qualified rat.
(2) medication
With 3 kinds of capsules obtained by embodiment, to wherein 3 groups of SD rat oral gavages administration, every day 2 times, each volume is 0.2ml/10g body weight, successive administration 26 weeks.Remaining one group is matched group, by same method gavage normal saline.Experimental animal is weighed weekly 1 time, according to body weight change adjustment dosage.24h after administration in the 13rd week, often organize execution 10, male and female half and half, observe and detect indices; Remaining continuation administration was observed to 26 weeks, and 24h after last 1 administration, often organizes and put to death 10 again, male and female half and half, observe and detect indices; Remaining 10 are carried out 8 week convalescent period and observe.
(3) test item and the time
General inspection: the general status observing animal every day, as the mental status, dynamic response, behavioral activity, the change of dietary amount, defecation situation, eyes and duct secretions, hair color, cleannes etc.Body weight change situation and food ration measure weekly 1 time.
Hematological examination: after administration, the 13rd, 26 week and drug withdrawal recover the end of term (the 34th week) and detect following index respectively: packed cell volume (HCT), red blood cell count(RBC) (RBC), content of hemoglobin (HGB), numeration of leukocyte (WBC), lymphocyte comparative counting (LY), platelet count (PLT), neutrophilic granulocyte comparative counting (NE), mononuclear cell comparative counting (Mon) and clotting time (CT).
Blood parameters checks: after administration the 13rd, 26 weeks and drug withdrawal recover the end of term (the 34th week) and detect following index respectively: alanine aminotransferase (ALT), alkali phosphatase (AST), Lomefloxacin aspartate injection (AST), total bilirubin (TB), albumin (ALB), gross protein (TP), blood glucose (GLU), blood urea nitrogen (BUN), T-CHOL (TC), creatinine (Crea), uric acid (UA), blood sodium (Na+), blood potassium (K+), blood calcium (Ca+) and B2M.
Urinate biochemical and urine routine: after administration, the 13rd, 26 week and drug withdrawal recover the end of term (the 34th week) each survey 1 time.Animal metabolism cage list cage is raised and is collected 24h urine, overnight fasting before test, detects urine bilirubin (BIL), glucose (GLU), ketoboidies (KET), protein, pH value, urobilinogen (URO), urine is occulted blood (BLO), nitrite (NIT), proportion and leukocyte (WBC); Quantitative determination of radioimmunoassay urine β 2-MG(renal tubular function obstacle sensitive indicator).
System postmortem and histopathologic examination: macroscopy is carried out to each internal organs, the organs such as heart, liver, lungs, kidney, spleen, brain, adrenal gland, thymus, thyroid, pancreas, uterus, ovary, testis, prostate are taken out and weighs, calculate organ coefficient (organ weights/body weight).With light microscopic, histological examination is carried out to above-mentioned internal organs and spinal cord, thymus, bladder, bone marrow (breastbone), duodenum, stomach, ileum, pancreas, hypophysis cerebri, optic nerve, lymph node, coton and rectal etc.
3, result of the test
The all rats of overview all do not show any abnormal conditions; Hematological examination, blood parameters inspection, urinate biochemical, urine routine, system postmortem and histopathologic examination, indices, compared with control animals, does not all have obvious difference.Therefore, Chinese medicine of the present invention to SD rat without any toxic action, in view of 20 times of ratios of its behaviour dose, so can infer that to take be safe to this Chinese medicine for patient.
The clinical trial of embodiment 5, Chinese medicinal capsule of the present invention
1, experimenter's data
Abdominal Incisional Hernia patient that experimenter all accepts for medical treatment year February in March, 2010 to 2014 from the People's Hospital of certain city the 4th (patients is: when standing, incision has hernia block to give prominence to, cough or firmly time more obvious; Usual hernia ring is comparatively large, flat sleeping after hernia block namely return voluntarily and receive disappearance; As hernia block has more greatly comparatively multi viscera and tissue outstanding, abdominal part dull pain can be had, involve the discomforts such as tenesmus), therefrom filter out patient 100 example being applicable to doing clinical trial, wherein man 54 example, age 25-62 year, female 46 example, age 23-60 year.
2, medication is tested
Investigational agent: the capsule obtained by the embodiment of the present invention 1, specification: amount to crude drug amount and be about 0.3g crude drug/capsules.
3, testing program
Capsule obtained by the oral embodiment of the present invention 1 of experimenter, each 2, every day 3 times.Within 4 weeks, be a course for the treatment of, treat 4 courses for the treatment of continuously.In medication process, the treatment such as itemized record adverse reactions of patients, physical recovery situation, medication impression situation.
4, evaluation criterion
(1) cure: Abdominal Incisional Hernia symptom disappears completely, and make a definite diagnosis through doctor and return to one's perfect health.
(2) effective: Abdominal Incisional Hernia symptom has improvement in various degree or alleviation.
(3) invalid: Abdominal Incisional Hernia is without any improvement, even more serious.
(4) untoward reaction: because of uncomfortable caused by drug administration or cause former disease other symptoms concurrent.
5, logging and analysis
Table 1 analysis of statistical results table
6, conclusion (of pressure testing)
As can be seen from statistical result, the tested patients taking Chinese medicine preparation of the present invention has no adverse reaction, cure rate 30%, total effective rate 93%.Visible, Chinese medicine preparation of the present invention has very significant curative effect, and technical advantage clearly.

Claims (4)

1. treat the Chinese medicine composition of Abdominal Incisional Hernia for one kind, it is characterized in that, described Chinese medicine composition is made up of the raw material of following weight portion: Fructus Toosendan 5-15 part, Fructus Citri tangerinae core 10-20 part, Semen Litchi 10-20 part, Fructus Crataegi 20-30 part, Radix Linderae 5-15 part, Radix Astragali 3-8 part, Radix Angelicae Sinensis 5-10 part, Rhizoma Dioscoreae 10-20 part, Rhizoma Curcumae 5-15 part, Herba Scutellariae Barbatae 10-20 part, Radix Aucklandiae 5-15 part, Myrrha 5-10 part, Radix Salviae Miltiorrhizae 5-15 part, Poria 10-20 part, Oletum Trogopterori 3-8 part, Semen Phaseoli 10-30 part, Radix Glycyrrhizae 10-30 part.
2. treat the Chinese medicine composition of Abdominal Incisional Hernia as claimed in claim 1, it is characterized in that, described Chinese medicine composition is made up of the raw material of following weight portion: Fructus Toosendan 10 parts, Fructus Citri tangerinae core 15 parts, Semen Litchi 15 parts, Fructus Crataegi 25 parts, the Radix Linderae 9 parts, the Radix Astragali 5 parts, Radix Angelicae Sinensis 8 parts, Rhizoma Dioscoreae 15 parts, Rhizoma Curcumae 13 parts, Herba Scutellariae Barbatae 15 parts, the Radix Aucklandiae 13 parts, Myrrha 8 parts, Radix Salviae Miltiorrhizae 10 parts, 15 parts, Poria, Oletum Trogopterori 5 parts, Semen Phaseoli 20 parts, 20 parts, Radix Glycyrrhizae.
3. treat the Chinese medicine composition of Abdominal Incisional Hernia as claimed in claim 1 or 2, it is characterized in that, the preparation method of described Chinese medicine composition is following steps:
Step 1, take Fructus Toosendan, the Radix Linderae, Fructus Citri tangerinae core, Semen Litchi, the Radix Aucklandiae, Radix Angelicae Sinensis 6 taste medical material by Chinese prescription of the present invention, pulverize respectively, mixing, adds the ethanol of the 50-65% of 5-9 times of weight, reflux 2-3 hour, filters; Filtering residue adds the ethanol of the 50-65% of 4-6 times of initial medical material weight, and reflux 1-2 hour filters; By twice filtrate mixing, distilling under reduced pressure removing ethanol, obtains extracting solution 1, for subsequent use;
Step 2, take the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Curcumae, Herba Scutellariae Barbatae, Fructus Crataegi, Myrrha, Radix Salviae Miltiorrhizae, Poria, Oletum Trogopterori, Semen Phaseoli, Radix Glycyrrhizae 11 taste medical material by Chinese prescription of the present invention, pulverize respectively, mixing, adds the purified water of 6-10 times of medical material weight, backflow decocts 1-3 hour, filters; Filtering residue adds the purified water of 4-8 times of initial medical material weight, and backflow decocts 1-2 hour, filters, and twice filtrate mixed, 1/4 of simmer down to original volume, is extracting solution 2;
Step 3, by extracting solution 1,2 mix, being concentrated into density is 1.20-1.36(70-80 DEG C of survey), be Chinese medical concrete;
Step 4, Chinese medical concrete is added adjuvant make finished product Chinese medicine preparation.
4. treat the Chinese medicine composition of Abdominal Incisional Hernia as claimed in claim 1 or 2, it is characterized in that: described Chinese medicine composition can make capsule, tablet or honey pill agent.
CN201410653666.7A 2014-11-18 2014-11-18 Chinese medicinal composition for treating abdominal incisional hernia and preparation method thereof Withdrawn CN104436033A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106729409A (en) * 2016-12-28 2017-05-31 济南市儿童医院 A kind of Chinese medicine composition for the nursing of children's indirect inguinal hernia

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104096035A (en) * 2014-06-26 2014-10-15 张志红 Traditional Chinese medicine composition for treating hernia

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104096035A (en) * 2014-06-26 2014-10-15 张志红 Traditional Chinese medicine composition for treating hernia

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106729409A (en) * 2016-12-28 2017-05-31 济南市儿童医院 A kind of Chinese medicine composition for the nursing of children's indirect inguinal hernia

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