CN107875233A - A kind of Chinese medicine composition for treating CGN and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating CGN and preparation method thereof Download PDFInfo
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- CN107875233A CN107875233A CN201711296437.4A CN201711296437A CN107875233A CN 107875233 A CN107875233 A CN 107875233A CN 201711296437 A CN201711296437 A CN 201711296437A CN 107875233 A CN107875233 A CN 107875233A
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Abstract
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition for treating CGN, in parts by weight, the Chinese medicine composition is made up of the raw material of following parts by weight：10~20 parts of Radix Codonopsis, 10~15 parts of the Radix Astragali, 10~20 parts of the bighead atractylodes rhizome, 10 25 parts of Poria cocos, 15~20 parts of Semen Cuscutae, 15~20 parts of barrenwort, 10~15 parts of psoralea corylifolia, 10~15 parts of the fruit of glossy privet, 10~15 parts of Eclipta prostrata, 10~20 parts of Radix Angelicae Sinensis, 10~20 parts of the root bark of tree peony, 10~15 parts of motherwort, 10~15 parts of the dried rhizome of rehmannia, 10~15 parts of Radix Notoginseng, 10~15 parts of Radix Sangusorbae, 6~9 parts of radix glycyrrhizae；The present invention is using Radix Codonopsis as monarch drug in a prescription, using the Radix Astragali and the bighead atractylodes rhizome as ministerial drug, with Semen Cuscutae, kidney-replenishing, barrenwort, psoralea corylifolia, the fruit of glossy privet, Eclipta prostrata, Radix Angelicae Sinensis, the root bark of tree peony, motherwort, the dried rhizome of rehmannia, Radix Notoginseng and Radix Sangusorbae are adjutant, radix glycyrrhizae using coordinating the drug actions of a prescription is makes medicine, system tune is carried out to the vital organs of the human body of human body, it is scorching that chronic glomerulus is treated from root.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition for treating CGN and its
Preparation method.
Background technology
CGN abbreviation chronic nephritis, it is basic clinical to mean albuminuria, blood urine, hypertension, oedema,
Mode of onset is had nothing in common with each other, and protracted inflammation, lesion is slowly in progress, and can have different degrees of renal hypofunction, and there is renal function to dislike
Change tendency and finally would develop into one group of renal glomerular disease of chronic renal failure.Due to this group of disease histological type and stadium not
Together, main clinical manifestation is different, and disease performance is in variation.At present in the treatment CGN of Clinical practice
Patent medicine is divided into two major classes：One is monomer component such as Chinese caterpillar fungus bacterial filament preparation；Another kind of is Chinese medicine compound prescription such as compound kidney inflammation tablets etc.
Deng.Preceding one kind is mainly shielded to kidney local damage, and the clinical manifestation that can not be directed to patients with chronic kidney disease is carried out
Treatment；Clinical manifestation of the latter class to Patients with Chronic Kidney Disease has certain effect, but the pathology of CKD kidney part changes
Becoming and be mostly activity lesion and inactive lesion and deposit, activity lesion cannot control, though clinical manifestation is chronic process, and
Progressive is in progress until developing into uremia by the lesion of kidney in itself.And pass through empirical discovery of practising medicine for many years, chronic renal is small
The generation of ball ephritis can also cause liver, the weakness of spleen, the dirty mutual shadow of liver and spleen kidney three not exclusively to the lesion to kidney, kidney
Ring, chronic glomerulus inflammation is progressively deteriorated, for this reason, it may be necessary to a kind of medicine adjusted that internal organs can be united, to from root
Treat CGN.
The content of the invention
To solve the above problems, the technical solution adopted by the present invention is：
A kind of Chinese medicine composition for treating CGN, in parts by weight, the Chinese medicine composition is by following weight
The raw material composition of part：10~20 parts of Radix Codonopsis, 10~15 parts of the Radix Astragali, 10~20 parts of the bighead atractylodes rhizome, Poria cocos 10-25 parts, Semen Cuscutae 15~20
Part, 15~20 parts of barrenwort, 10~15 parts of psoralea corylifolia, 10~15 parts of the fruit of glossy privet, 10~15 parts of Eclipta prostrata, 10~20 parts of Radix Angelicae Sinensis,
10~20 parts of the root bark of tree peony, 10~15 parts of motherwort, 10~15 parts of the dried rhizome of rehmannia, 10~15 parts of Radix Notoginseng, 10~15 parts of Radix Sangusorbae, radix glycyrrhizae 6
~9 parts.
More excellent component is：The Chinese medicine composition is made up of the raw material of following parts by weight：12~18 parts of Radix Codonopsis, the Radix Astragali 11~14
Part, 12~18 parts of the bighead atractylodes rhizome, 10~25 parts of Poria cocos, 15~20 parts of Semen Cuscutae, 15~20 parts of barrenwort, 11~14 parts of psoralea corylifolia, female
Loyal 11~14 parts of son, 11~14 parts of Eclipta prostrata, 12~18 parts of Radix Angelicae Sinensis, 12~18 parts of the root bark of tree peony, 11~14 parts of motherwort, the dried rhizome of rehmannia 11~
14 parts, 11~14 parts of Radix Notoginseng, 11~14 parts of Radix Sangusorbae, 6~9 parts of radix glycyrrhizae.
Optimal component is：The Chinese medicine composition is made up of the raw material of following parts by weight：15 parts of Radix Codonopsis, 13 parts of the Radix Astragali, the bighead atractylodes rhizome
15 parts, 15 parts of Poria cocos, 16 parts of Semen Cuscutae, 18 parts of barrenwort, 12 parts of psoralea corylifolia, 13 parts of the fruit of glossy privet, 12 parts of Eclipta prostrata, Radix Angelicae Sinensis 15
Part, 16 parts of the root bark of tree peony, 12 parts of motherwort, 13 parts of the dried rhizome of rehmannia, 12 parts of Radix Notoginseng, 13 parts of Radix Sangusorbae, 7 parts of radix glycyrrhizae；Or, 17 parts of Radix Codonopsis, Huang
12 parts of stilbene, 16 parts of the bighead atractylodes rhizome, 20 parts of Poria cocos, 18 parts of Semen Cuscutae, 17 parts of barrenwort, 13 parts of psoralea corylifolia, 12 parts of the fruit of glossy privet, Eclipta prostrata 13
Part, 16 parts of Radix Angelicae Sinensis, 15 parts of the root bark of tree peony, 13 parts of motherwort, 12 parts of the dried rhizome of rehmannia, 13 parts of Radix Notoginseng, 12 parts of Radix Sangusorbae, 8 parts of radix glycyrrhizae.
Further, the Chinese medicine composition of above-mentioned treatment CGN, the Chinese medicine composition can be made liniment,
Any one in pulvis, capsule and decoction.
The invention discloses a kind of preparation method for the Chinese medicine composition for treating CGN, formulation is capsule,
Comprise the following steps：
Step (1)：Parts by weight of raw materials according to the Chinese medicine composition of the treatment CGN weighs Radix Codonopsis, Huang
Stilbene, the bighead atractylodes rhizome, Poria cocos, Semen Cuscutae, barrenwort, psoralea corylifolia, the fruit of glossy privet, Eclipta prostrata, Radix Angelicae Sinensis, the root bark of tree peony, motherwort, the dried rhizome of rehmannia, Radix Notoginseng,
Radix Sangusorbae, radix glycyrrhizae；
Step (2)：The Chinese medicine material weighed in step (1) is placed in 10~15min of immersion in clear water, removed miscellaneous in medicinal powder
Thing；
Step (3)：Chinese medicine material obtained by step (2) is pulled out from water, is placed under natural light and dries；Dry rear aqueous
Rate is controlled less than also equal to 98%；
Step (4)：Step (3) dried Chinese medicine is placed in grinding machine for Chinese herb medicines and pulverized, crosses 500~800 mesh sieves
After point, sterilization processing 12~24 hours under UV light sterilization lamp；
Step (5)：The herb powder that step (4) obtains is filled in capsule, that is, obtain medical treatment CGN
Chinese medicinal capsule.
The invention discloses the preparation method of the Chinese medicine composition of the treatment CGN described in second, formulation
For pulvis, comprise the following steps：
Step (1)：Parts by weight of raw materials according to the Chinese medicine composition of the treatment CGN weighs Radix Codonopsis, Huang
Stilbene, the bighead atractylodes rhizome, Poria cocos, Semen Cuscutae, barrenwort, psoralea corylifolia, the fruit of glossy privet, Eclipta prostrata, Radix Angelicae Sinensis, the root bark of tree peony, motherwort, the dried rhizome of rehmannia, Radix Notoginseng,
Radix Sangusorbae, radix glycyrrhizae；
Step (2)：The Chinese medicine material weighed in step (1) is placed in 10~15min of immersion in clear water, removed miscellaneous in medicinal powder
Thing；
Step (3)：Chinese medicine material obtained by step (2) is pulled out from water, is placed under natural light and dries；Dry rear aqueous
Rate is controlled less than also equal to 98%；
Step (4)：Step (3) dried Chinese medicine is placed in grinding machine for Chinese herb medicines and pulverized, crosses 500~800 mesh sieves
After point, sterilization processing 12~24 hours under UV light sterilization lamp；
Step (5)：The herb powder that step (4) obtains is fitted into Chinese medicine net bag, that is, obtain medical treatment chronic glomerulus kidney
Scorching Chinese medicine powder.
The invention discloses the preparation method of the Chinese medicine composition of the treatment CGN described in the third, formulation
For decoction, comprise the following steps：
Step (1)：Parts by weight of raw materials according to the Chinese medicine composition of the treatment CGN weighs Radix Codonopsis, Huang
Stilbene, the bighead atractylodes rhizome, Poria cocos, Semen Cuscutae, barrenwort, psoralea corylifolia, the fruit of glossy privet, Eclipta prostrata, Radix Angelicae Sinensis, the root bark of tree peony, motherwort, the dried rhizome of rehmannia, Radix Notoginseng,
Radix Sangusorbae, radix glycyrrhizae；
Step (2)：The Chinese medicine material weighed in step (1) is placed in medicine pot, and adds clear water immersion 30min, is removed
Debris in medicinal powder；The addition of clear water is advisable with flooding all Chinese medicine materials, after immersion, after boiling by intense fire, and slow fire heating
30~50 minutes, filter to obtain a decoction；
Step (3)：Add clear water in the dregs of a decoction into step (2) in marmite, the addition of clear water is to flood all dregs of a decoction
It is advisable, carries out second and decoct, first boil by intense fire, then be cooked by slow fire 30 minutes, filters to obtain secondary decoction；
Step (4)：Gained decoction in step (2) and step (3) is merged, pack, ice is placed in after naturally cooling to room temperature
Refrigerated in case, refrigerated storage temperature is controlled at 0~5 DEG C, and the traditional Chinese herbal decoction for the treatment of CGN is thus made.
Each component pharmacology is as follows：
Radix Codonopsis：It is sweet, flat, returns spleen, lung channel；Effect：Matter moistens gas and has strengthening the spleen and tonifying the lung, nourishing qi and blood promotes the production of body fluid, and cures mainly taste
Weakness, anorexia and loose stool, lassitude hypodynamia, the deficiency syndrome of the lung are breathed with cough, the lazy speech of shortness of breath, spontaneous perspiration, and blood deficiency chlorosis is thirsty.Strengthen passive protective physical fitness, drop
Low blood pressure, blood-nourishing, tonifying middle-Jiao and Qi, treatment gastric ulcer, treatment diabetes.
The Radix Astragali：Sweet, tepor, return lung, spleen, liver and kidney channel.Effect：Invigorating qi for consolidating superficies, arrest sweating admittedly take off, torr sore myogenic, Li Shui disappear
It is swollen.For treating treatment deficiency of vital energy weak, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, ulcer is difficult to burst, burst for a long time and does not holds back, blood
Empty sallow, Heat Diabetes, chronic nephritis, albuminuria, diabetes etc..Astragalus root invigorating middle warmer and replenishing QI, raw solid table torr sore.
The bighead atractylodes rhizome：Bitter, it is sweet, it is warm-natured.Returns spleen, stomach.Effect：Strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis are antiabortive.For insufficiency of the spleen
Deficiency of food, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, fetal irritability.
Poria cocos：It is sweet, light, mild-natured, the thoughts of returning home, lung, spleen, kidney channel.Effect：Clearing damp and promoting diuresis, invigorating the spleen, calming heart.Urinated for oedema
It is few, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
Semen Cuscutae：It is sweet, warm, return kidney,liver,spleen to pass through.Effect：Nourishing liver and kidney, astringent sperm contracting urine, antiabortive, improving eyesight, antidiarrheal.With
In lumbago due to the kidney deficiency, impotence and seminal emission, frequent micturition, uterus cold infertile, the dark loose stool of mesh kidney yin yang deficiency syndrome.
Barrenwort：It is pungent, sweet, warm-natured, enter liver and kidney channel.Effect：Kidney-replenishing, strengthening the bones and muscles, wind-damp dispelling.For impotence and seminal emission, muscle
The atrophic debility of bones is soft, arthralgia pain due to rheumatism, waist knee impotence, cold extremities with aversion to cold, numbness contracture；Climacteric hypertension.
Psoralea corylifolia：It is bitter, pungent, warm, return kidney, the spleen channel.Effect：Tonifying kidney and strengthening yang, astringent sperm contracting urine, lumbago due to the kidney deficiency, frequent urination are small
Youngster's enuresis, kidney leakage, warming spleen and stopping diarrha, gas of receiving is relievingd asthma.For treating impotence due to deficiency of the kidney, soreness and weakness of waist and knees crymodynia, emission due to the kidney deficiency, the enuresis, urine
Frequently, the insufficiency of both the spleen and the kindey, the failure of the kidney in receiving air.
The fruit of glossy privet：It is sweet, bitter, cool, return liver and kidney channel.Effect：Tonify the liver and kidney, improving eyesight, clearind deficient heat.Mesh for the deficiency of liver-yin and kidney-yin
Secretly fail to understand, hypopsia, poliosis, soreness of waist tinnitus and fever due to yin deficiency.
Eclipta prostrata (Eclipta prostrata)：Sweet sour, cool in nature, enter liver kidney two warp is nontoxic.Effect：Nourishing liver and kidney, cooling blood and hemostasis.For
The diseases such as various haematemesis, nosebleed, hemoptysis, enterorrhagia, hematuria, hemorrhoid hemorrhage, metrorrhagia.Smash juice and apply eyebrow hair, hair growth can be promoted,
It is for oral administration to have black hair, dark hair.
Radix Angelicae Sinensis：It is sweet, pungent, warm, nontoxic, Return liver, the heart, the spleen channel.Effect：Enrich blood；Promoting blood circulation；Menstruction regulating and pain relieving；Moisturize laxation.Main blood
Empty all cards；Irregular menstruation；Amenorrhea；Dysmenorrhoea；Abdominal mass knot gathers；Uterine bleeding；Asthenia cold abdominalgia；Impotence numbness；Numbness；Intestines are dry and shit is difficult；Dysentery characterized by blood in the stool
After weigh；Ulcer sores；Injury from falling down.
The root bark of tree peony (moutan bark)：Bitter, it is pungent, be slightly cold, the thoughts of returning home, liver and kidney channel.Effect：Clearing heat and cooling blood；Promoting blood circulation to remove blood stasis.For temperature
Pyreticosis heat invading xuefen；Send out spot；Hematemesis；Pyreticosis later stage hot Fu Yin distributions heat；Deficiency of Yin osteopyrexia and fever；Amenorrhea due to stagnation of blood；Dysmenorrhoea；Carbuncle swells sore
Poison；The pain of injury caused by falling and tumbling；Beriberoid pyretic arthralgia.
Motherwort：Acrid flavour, hardship, property it is micro- enter, enter the heart, spleen, kidney three and pass through.Effect：Promoting blood circulation, dissolving stasis, menstruation regulating, disappear water.For controlling
Irregular menstruation, threatened abortion difficult labour, placenta retension, postpartum anemic fainting, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle swells sore.
The dried rhizome of rehmannia (radix rehmanniae recen)：It is sweet, cold, the thoughts of returning home, liver, kidney channel.Effect：Clearing heat and cooling blood, yin-nourishing, promote the production of body fluid.It is deep red for pyreticosis tongue
Polydipsia, yin asthenia generating intrinsic heat, hectic fever due to yin labor heat, Heat Diabetes, spit blood, bleeding from five sense organs or subcutaneous tissue, spot dermexanthesis.
Radix Notoginseng (pseudo-ginseng)：Sweet, slight bitter, temperature, Return liver, stomach.Effect：Dissipate stasis of blood hemostasis, detumescence ding-tong.For spitting blood, tell
Blood, bleeding from five sense organs or subcutaneous tissue, have blood in stool, uterine bleeding, traumatism and bleeding, chest and abdomen shouting pain, tumbling and swelling.
Radix Sangusorbae：It is bitter, sour, puckery, be slightly cold, Return liver, large intestine channel.Cooling blood and hemostasis, removing toxic substances sore.For having blood in stool, hemorrhoid blood, blood
Dysentery, uterine bleeding, scald, carbuncle sore tumefacting virus.
Radix glycyrrhizae：Crust brown, the inside is faint yellow, has sweet taste.Effect：Cure mainly clearing heat and detoxicating, expelling phlegm and arresting coughing, gastral cavity abdomen, palpitaition
Palpitation, intermittent pulse and deficiency of spleen-QI and stomach-QI, ulcer sores, abscess of throat.
" organic conception " is had been accepted as at present, " diagnosis and treatment based on an overall analysis of the illness and the patient's condition ", " compound use ", " compound compatibility medication is such as used military forces " are the traditional Chinese medical science
Most scientific maximally effective several big advantages, wherein " compound compatibility medication is such as used military forces " is the original theory of traditional Chinese medicine of very science.In
The tight compatibility that each medicine is all linked with one another as arraying troops for battle in prescription is cured, is that it is better than the effective means of western medicine formula.The traditional Chinese medical science
Prescription theory thinks, each prescription, not only needs to select the suitable appropriate compatibility of medicine according to etiology and pathogenesis, while should also accord with
Close the prescription compatibility theory of the basic structure of prescription, i.e. " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make ", just
It is that it establishes the scientific matching on the comprehensive judgement basis to the disease interpretation of the cause, onset and process of an illness.Middle medical square is whole by too many levels, Mutiple Targets
The biological mechanism of regulation is closed, therapeutic effect more more longlasting than Western medicine, that more green natural has no toxic side effect can be obtained, and it is this
Curative effect is built upon on the original theoretical accurate instruction of above-mentioned traditional Chinese medical science tradition, and the present invention just have followed this principle.
Monarch drug in a prescription treats primary symptom in the side of referring to, plays the medicine of primary treatment, can use as required simply or a few taste medicines.Minister
Medicine is the medicine assisted main ingredient or strengthen main ingredient effect.Adjutant is the medicine for the toxicity assisted main ingredient treatment and disease or suppress main ingredient
Thing.Make the effect that medicine is the through diseased region of each medicine of guiding or each medicine of mediation.
The Chinese medicine composition for the treatment of CGN of the present invention, is promoted the production of body fluid with strengthening the spleen and tonifying the lung, nourishing qi and blood
Radix Codonopsis is monarch drug in a prescription, with invigorating qi for consolidating superficies, arrest sweating admittedly take off, torr sore myogenic, the Radix Astragali of inducing diuresis for removing edema and strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect it is white
Art is ministerial drug, with clearing damp and promoting diuresis, invigorating the spleen, calming heart Poria cocos, nourishing liver and kidney, astringent sperm contracting urine Semen Cuscutae, kidney-replenishing, strengthening the bones and muscles,
The barrenwort of wind-damp dispelling, the psoralea corylifolia that tonifying kidney and strengthening yang, astringent sperm contracting urine, warming spleen and stopping diarrha, gas of receiving are relievingd asthma, tonify the liver and kidney, improving eyesight, clearly void
The fruit of glossy privet of heat, nourishing liver and kidney, cooling blood and hemostasis Eclipta prostrata, the Radix Angelicae Sinensis enrich blood, invigorated blood circulation, clearing heat and cooling blood, the root bark of tree peony of promoting blood circulation to remove blood stasis,
Promoting blood circulation, the motherwort of dissolving stasis, clearing heat and cooling blood, the dried rhizome of rehmannia of nourishing Yin and promoting production of body fluid, dissipate stasis of blood hemostasis, the Radix Notoginseng of detumescence ding-tong, and cool blood are stopped
Blood, the Radix Sangusorbae of removing toxic substances sore are adjutant, and using the radix glycyrrhizae of coordinating the drug actions of a prescription as medicine is made, compatibility is reasonable, blood-enrich, heat-clearing excreting dampness,
The vital organs of the human body of human body are carried out system tune by warming and invigorating kidney Yang, regulation channels and collaterals, and chronic glomerulus inflammation is treated from root, good effect, is seen
Effect is fast, treats both principal and secondary aspect of disease, and cures short treating period, uneasy to recur, low-cost.
The Chinese medicine composition can be prepared into the diversified forms such as Chinese medicinal tablet, particle, traditional Chinese medicine pill, be not limited to decoction and
Capsule, suitable for a variety of therapeutic modalities, application method.
Embodiment
The present invention is further described with reference to embodiment.
Embodiment 1
A kind of Chinese medicine composition for treating CGN, in parts by weight, the Chinese medicine composition is by following weight
The raw material composition of part：10 parts of Radix Codonopsis, 15 parts of the Radix Astragali, 10 parts of the bighead atractylodes rhizome, 25 parts of Poria cocos, 15 parts of Semen Cuscutae, 20 parts of barrenwort, psoralea corylifolia
10 parts, 15 parts of the fruit of glossy privet, 10 parts of Eclipta prostrata, 20 parts of Radix Angelicae Sinensis, 10 parts of the root bark of tree peony, 15 parts of motherwort, 10 parts of the dried rhizome of rehmannia, 15 parts of Radix Notoginseng,
10 parts of Radix Sangusorbae, 9 parts of radix glycyrrhizae.
Embodiment 2
A kind of Chinese medicine composition for treating CGN, in parts by weight, the Chinese medicine composition is by following weight
The raw material composition of part：20 parts of Radix Codonopsis, 10 parts of the Radix Astragali, 20 parts of the bighead atractylodes rhizome, 10 parts of Poria cocos, 20 parts of Semen Cuscutae, 15 parts of barrenwort, psoralea corylifolia
15 parts, 10 parts of the fruit of glossy privet, 15 parts of Eclipta prostrata, 10 parts of Radix Angelicae Sinensis, 20 parts of the root bark of tree peony, 10 parts of motherwort, 15 parts of the dried rhizome of rehmannia, 10 parts of Radix Notoginseng,
15 parts of Radix Sangusorbae, 6 parts of radix glycyrrhizae.
Embodiment 3
A kind of Chinese medicine composition for treating CGN, in parts by weight, the Chinese medicine composition is by following weight
The raw material composition of part：12 parts of Radix Codonopsis, 14 parts of the Radix Astragali, 12 parts of the bighead atractylodes rhizome, 25 parts of Poria cocos, 15 parts of Semen Cuscutae, 20 parts of barrenwort, psoralea corylifolia
11 parts, 14 parts of the fruit of glossy privet, 11 parts of Eclipta prostrata, 18 parts of Radix Angelicae Sinensis, 12 parts of the root bark of tree peony, 11 parts of motherwort, 14 parts of the dried rhizome of rehmannia, 11 parts of Radix Notoginseng,
14 parts of Radix Sangusorbae, 6 parts of radix glycyrrhizae.
Embodiment 4
A kind of Chinese medicine composition for treating CGN, in parts by weight, the Chinese medicine composition is by following weight
The raw material composition of part：18 parts of Radix Codonopsis, 11 parts of the Radix Astragali, 18 parts of the bighead atractylodes rhizome, 10 parts of Poria cocos, 20 parts of Semen Cuscutae, 15 parts of barrenwort, psoralea corylifolia
14 parts, 11 parts of the fruit of glossy privet, 14 parts of Eclipta prostrata, 12 parts of Radix Angelicae Sinensis, 18 parts of the root bark of tree peony, 14 parts of motherwort, 11 parts of the dried rhizome of rehmannia, 14 parts of Radix Notoginseng,
11 parts of Radix Sangusorbae, 9 parts of radix glycyrrhizae.
Embodiment 5
A kind of Chinese medicine composition for treating CGN, in parts by weight, the Chinese medicine composition is by following weight
The raw material composition of part：15 parts of Radix Codonopsis, 13 parts of the Radix Astragali, 15 parts of the bighead atractylodes rhizome, 15 parts of Poria cocos, 16 parts of Semen Cuscutae, 18 parts of barrenwort, psoralea corylifolia
12 parts, 13 parts of the fruit of glossy privet, 12 parts of Eclipta prostrata, 15 parts of Radix Angelicae Sinensis, 16 parts of the root bark of tree peony, 12 parts of motherwort, 13 parts of the dried rhizome of rehmannia, 12 parts of Radix Notoginseng,
13 parts of Radix Sangusorbae, 7 parts of radix glycyrrhizae.
Embodiment 6
A kind of Chinese medicine composition for treating CGN, in parts by weight, the Chinese medicine composition is by following weight
The raw material composition of part：17 parts of Radix Codonopsis, 12 parts of the Radix Astragali, 16 parts of the bighead atractylodes rhizome, 20 parts of Poria cocos, 18 parts of Semen Cuscutae, 17 parts of barrenwort, psoralea corylifolia
13 parts, 12 parts of the fruit of glossy privet, 13 parts of Eclipta prostrata, 16 parts of Radix Angelicae Sinensis, 15 parts of the root bark of tree peony, 13 parts of motherwort, 12 parts of the dried rhizome of rehmannia, 13 parts of Radix Notoginseng,
12 parts of Radix Sangusorbae, 8 parts of radix glycyrrhizae.
Embodiment 7：Capsule is made
The preparation method of the Chinese medicine composition for the treatment of CGN described in embodiment 1~6, formulation is capsule,
Comprise the following steps：
Step (1)：Parts by weight of raw materials according to the Chinese medicine composition of the treatment CGN weighs Radix Codonopsis, Huang
Stilbene, the bighead atractylodes rhizome, Poria cocos, Semen Cuscutae, barrenwort, psoralea corylifolia, the fruit of glossy privet, Eclipta prostrata, Radix Angelicae Sinensis, the root bark of tree peony, motherwort, the dried rhizome of rehmannia, Radix Notoginseng,
Radix Sangusorbae, radix glycyrrhizae；
Step (2)：The Chinese medicine material weighed in step (1) is placed in 10~15min of immersion in clear water, removed miscellaneous in medicinal powder
Thing；
Step (3)：Chinese medicine material obtained by step (2) is pulled out from water, is placed under natural light and dries；Dry rear aqueous
Rate is controlled less than also equal to 98%；
Step (4)：Step (3) dried Chinese medicine is placed in grinding machine for Chinese herb medicines and pulverized, crosses 500~800 mesh sieves
After point, sterilization processing 12~24 hours under UV light sterilization lamp；
Step (5)：The herb powder that step (4) obtains is fitted into capsule, that is, obtain medical treatment CGN
Chinese medicinal capsule.
Pulvis is made in embodiment 8
The preparation method of the Chinese medicine composition for the treatment of CGN described in embodiment 1~6, formulation is pulvis,
Comprise the following steps：
Step (1)：Parts by weight of raw materials according to the Chinese medicine composition of the treatment CGN weighs Radix Codonopsis, Huang
Stilbene, the bighead atractylodes rhizome, Poria cocos, Semen Cuscutae, barrenwort, psoralea corylifolia, the fruit of glossy privet, Eclipta prostrata, Radix Angelicae Sinensis, the root bark of tree peony, motherwort, the dried rhizome of rehmannia, Radix Notoginseng,
Radix Sangusorbae, radix glycyrrhizae；
Step (2)：The Chinese medicine material weighed in step (1) is placed in 10~15min of immersion in clear water, removed miscellaneous in medicinal powder
Thing；
Step (3)：Chinese medicine material obtained by step (2) is pulled out from water, is placed under natural light and dries；Dry rear aqueous
Rate is controlled less than also equal to 98%；
Step (4)：Step (3) dried Chinese medicine is placed in grinding machine for Chinese herb medicines and pulverized, crosses 500~800 mesh sieves
After point, sterilization processing 12~24 hours under UV light sterilization lamp；
Step (5)：The herb powder that step (4) obtains is fitted into Chinese medicine net bag, that is, obtain medical treatment chronic glomerulus kidney
Scorching Chinese medicine powder.
Decoction is made in embodiment 9
The preparation method of the Chinese medicine composition for the treatment of CGN described in embodiment 1~6, formulation is decoction,
Comprise the following steps：
Step (1)：Parts by weight of raw materials according to the Chinese medicine composition of the treatment CGN weighs Radix Codonopsis, Huang
Stilbene, the bighead atractylodes rhizome, Poria cocos, Semen Cuscutae, barrenwort, psoralea corylifolia, the fruit of glossy privet, Eclipta prostrata, Radix Angelicae Sinensis, the root bark of tree peony, motherwort, the dried rhizome of rehmannia, Radix Notoginseng,
Radix Sangusorbae, radix glycyrrhizae；
Step (2)：The Chinese medicine material weighed in step (1) is placed in medicine pot, and adds clear water immersion 30min, is removed
Debris in medicinal powder；The addition of clear water is advisable with flooding all Chinese medicine materials, after immersion, after boiling by intense fire, and slow fire heating
30~50 minutes, filter to obtain a decoction；
Step (3)：Add clear water in the dregs of a decoction into step (2) in marmite, the addition of clear water is to flood all dregs of a decoction
It is advisable, carries out second and decoct, first boil by intense fire, then be cooked by slow fire 30 minutes, filters to obtain secondary decoction；
Step (4)：Gained decoction in step (2) and step (3) is merged, pack, ice is placed in after naturally cooling to room temperature
Refrigerated in case, refrigerated storage temperature is controlled at 0~5 DEG C, and the traditional Chinese herbal decoction for the treatment of CGN is thus made.
Toxicity test
Choose that the suitable adult of body weight is female, male each 100 of small white mouse, be divided into control group and administration group, rearing conditions ensure
It is completely the same, control group not medicine feed, the daily morning and evening medicine feed of administration group 2 times, the health of each small white mouse is recorded daily, is taken the photograph
Food, drinking-water, body weight, test duration six months, compared with control group, administration group small white mouse health, ingest, drink water, body weight
Growth is normal, and has no that small white mouse is sick or dead.Prompt the medicine security good, have no toxic side effect.
The present invention has carried out clinical efficacy tracking with the data given by embodiment 5, and curative effect is summarized as follows：
1. choosing CGN case load 200, average age 45.3 years old, patient is randomly divided into four groups, controlled
There was no significant difference for the data such as treatment group 50, control group 150, two groups of ages, has comparativity.
2. treatment method, the oral Chinese medicine composition made from optimization formula embodiment 5 of the present invention for the treatment of group, per bu sooner or later
Take decoction twice, course for the treatment of 7 days.
Dietetic contraindication：(1) quit smoking, wine, coffee, cocoa.(2) food of pungent, scorching dynamic blood is avoided.(3) avoid and go mouldy, be oily
Decoct, rich food.
3. diagnostic criteria
Reference《Modern Chinese medicine clinical diagnostics》In diagnosis basis carry out clinical diagnosis：
Complete incidence graph：Complete incidence graph：Edema, pain in the back are wholly absent, and Urine proteins continue feminine gender, and twenty-four-hour urine protein quantification is held
It is continuous to be less than 0.3g, normal renal function；
It is basic to alleviate：Edema disappears substantially with pain in the back, and Urine proteins persistently reduce more than 50%, normal renal function or substantially just
Often (differed with normal value no more than 15%)；
Take a turn for the better：Oedema is clearly better with pain in the back, and twenty-four-hour urine protein content persistently reduces 25%~49%, normal renal function or
There is improvement；
It is invalid：Clinical manifestation is existing and laboratory examination is not improved or adds severe one on the contrary.；
Total effective rate=(complete incidence graph+basic alleviation+improvement)/n × 100%.
4. clinical observation experiment result：
Case load 200, wherein treatment group 50；Control group 150, control group stochastic averagina are divided into three groups, every group 50.
Treatment group：The preparation method that the prescription used provides for the prescription of embodiment 5, embodiment 10,
Control group 1：Using scarce monarch drug in a prescription (Radix Codonopsis)：A kind of Chinese medicine composition for treating CGN, with weight
Part meter is measured, the Chinese medicine composition is made up of the raw material of following parts by weight：13 parts of the Radix Astragali, 15 parts of the bighead atractylodes rhizome, 15 parts of Poria cocos, Semen Cuscutae 16
Part, 18 parts of barrenwort, 12 parts of psoralea corylifolia, 13 parts of the fruit of glossy privet, 12 parts of Eclipta prostrata, 15 parts of Radix Angelicae Sinensis, 16 parts of the root bark of tree peony, 12 parts of motherwort,
13 parts of the dried rhizome of rehmannia, 12 parts of Radix Notoginseng, 13 parts of Radix Sangusorbae, 7 parts of radix glycyrrhizae.
Control group 2：Using scarce ministerial drug (Radix Astragali)：A kind of Chinese medicine composition for treating CGN, with weight
Part meter is measured, the Chinese medicine composition is made up of the raw material of following parts by weight：15 parts of Radix Codonopsis, 15 parts of the bighead atractylodes rhizome, 15 parts of Poria cocos, Semen Cuscutae 16
Part, 18 parts of barrenwort, 12 parts of psoralea corylifolia, 13 parts of the fruit of glossy privet, 12 parts of Eclipta prostrata, 15 parts of Radix Angelicae Sinensis, 16 parts of the root bark of tree peony, 12 parts of motherwort,
13 parts of the dried rhizome of rehmannia, 12 parts of Radix Notoginseng, 13 parts of Radix Sangusorbae, 7 parts of radix glycyrrhizae.
Control group 3：Using scarce ministerial drug (bighead atractylodes rhizome)：A kind of Chinese medicine composition for treating CGN, with weight
Part meter is measured, the Chinese medicine composition is made up of the raw material of following parts by weight：15 parts of Radix Codonopsis, 13 parts of the Radix Astragali, 15 parts of Poria cocos, Semen Cuscutae 16
Part, 18 parts of barrenwort, 12 parts of psoralea corylifolia, 13 parts of the fruit of glossy privet, 12 parts of Eclipta prostrata, 15 parts of Radix Angelicae Sinensis, 16 parts of the root bark of tree peony, 12 parts of motherwort,
13 parts of the dried rhizome of rehmannia, 12 parts of Radix Notoginseng, 13 parts of Radix Sangusorbae, 7 parts of radix glycyrrhizae.
Treatment group, male 25, women 25,20~70 years old age, disease time 1 year~10 years.Treatment cycle be 3~
8 courses for the treatment of, complete remission rate 62%, basic remission rate are 74%, total effective rate 92%.
Control group 1, male 25, women 25,20~70 years old age, disease time 1 year~10 years.Treatment cycle is 3
~8 courses for the treatment of, complete remission rate rate 6%, basic remission rate are 24%, total effective rate 22%.
Control group 2, male 25, women 25,20~70 years old age, disease time 1 year~10 years.Treatment cycle is 3
~8 courses for the treatment of, complete remission rate 4%, basic remission rate are 14%, total effective rate 24%.
Control group 3, male 25, women 25,20~70 years old age, disease time 1 year~10 years.Treatment cycle is 3
~8 courses for the treatment of, complete remission rate 8%, basic remission rate are 12%, total effective rate 32%.
5. model case
5.1 Zhengs, female, 43 years old.Often weak, burnout, the soreness of waist, poor appetite, oedema cut in and out, palpebral edema, under
Limb pitting edema, through chemically examining Urine proteins increase, arena erythremia, its pulse condition is looked into as damp-heat accumulation, disturbance in qi transformation, wet
CGN caused by thermal agitation.Come here with laboratory test report, according to its symptom and inspection result, give of the invention real
The prescription of example 5 is applied, decoction is made, morning and evening one after each meal, takes this medicine 1 month, symptom mitigation, above-mentioned symptom after taking medicine 3 months
Disappear, after continue to take 5 months, do not recur so far.
5.2 Mr. Wang, males, 32 years old.Often occur that tired, powerless, waist is ached, lost the appetite, face is empty yellow, face is grey
In vain, Fundus oculi artery attenuates, has the symptoms such as arteriovenous crossing compression.Through chemically examine Urine proteins dramatically increase, look into its pulse condition be diagnosed as it is wet
Heat is pented up, disturbance in qi transformation, damp and hot disturbance, be diagnosed as CGN after diagnosing.Take this medicine symptom mitigation after 2 months, 4
Above-mentioned symptom disappears after individual month, does not recur so far.
5.3 Bais, man, 58 years old, be initially just incoordination between the liver and the spleen, often does the work of manual labor later, it is necessary to constantly
Bend over remove weight, cause renal function to be deteriorated, later with the growth of age, eyeground edema and edema of lower extremity phenomenon occur,
This just starts to arouse attention, and goes examination in hospital scorching for chronic glomerulus, and Urine proteins are the positive, and urine protein content is high, comes here,
Just start to give the formula of the embodiment of the present invention 5, decoction is made, after two weeks, symptom is relieved, and after six weeks, edema starts to delay
Solution, pain in the back disappear more than half, adhere to medication two months again, and 24 disappearance quantity of proteinuria stop taking for decoction of medicinal ingredients continuously less than 0.3g,
Pill is made in the formula of the embodiment of the present invention 5, and has persistently been taken 3 months, it is proposed that its not dry weight muscular labor, is all had no so far
Recurrence.
5.4 Mr. Wangs, man, 62 years old, are engaged in heavy physical labour, cause renal function to be deteriorated, later with age throughout the year
Increase, eyeground edema and edema of lower extremity phenomenon occur, go examination in hospital scorching for chronic glomerulus, Urine proteins is positive, Urine proteins
Content is high, comes here, has just started to give the formula of the embodiment of the present invention 5, decoction is made, and after two weeks, symptom is relieved, and three
Zhou Hou, edema start to alleviate, and pain in the back disappears more than half, adheres to medication two months again, 24 disappearance quantity of proteinuria continuously less than 0.3g,
Stop decoction of medicinal ingredients taking, so far all no relapse.
The foregoing description of the disclosed embodiments, professional and technical personnel in the field are enable to realize or using the present invention.
A variety of modifications to these embodiments will be apparent for those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, it is of the invention
The embodiments shown herein is not intended to be limited to, but more to be met and principles disclosed herein and features of novelty phase
Consistent most wide scope.
Claims (8)
- A kind of 1. Chinese medicine composition for treating CGN, it is characterised in that in parts by weight, the Chinese medicine composition by The raw material composition of following parts by weight：10~20 parts of Radix Codonopsis, 10~15 parts of the Radix Astragali, 10~20 parts of the bighead atractylodes rhizome, Poria cocos 10-25 parts, Tu silks 15~20 parts of son, 15~20 parts of barrenwort, 10~15 parts of psoralea corylifolia, 10~15 parts of the fruit of glossy privet, 10~15 parts of Eclipta prostrata, Radix Angelicae Sinensis 10 ~20 parts, 10~20 parts of the root bark of tree peony, 10~15 parts of motherwort, 10~15 parts of the dried rhizome of rehmannia, 10~15 parts of Radix Notoginseng, Radix Sangusorbae 10~15 Part, 6~9 parts of radix glycyrrhizae.
- 2. the Chinese medicine composition for the treatment of CGN according to claim 1, it is characterised in that the Chinese traditional medicine composition Thing is made up of the raw material of following parts by weight：12~18 parts of Radix Codonopsis, 11~14 parts of the Radix Astragali, 12~18 parts of the bighead atractylodes rhizome, 10~25 parts of Poria cocos, 15~20 parts of Semen Cuscutae, 15~20 parts of barrenwort, 11~14 parts of psoralea corylifolia, 11~14 parts of the fruit of glossy privet, 11~14 parts of Eclipta prostrata, when Return 12~18 parts, 12~18 parts of the root bark of tree peony, 11~14 parts of motherwort, 11~14 parts of the dried rhizome of rehmannia, 11~14 parts of Radix Notoginseng, Radix Sangusorbae 11~ 14 parts, 6~9 parts of radix glycyrrhizae.
- 3. the Chinese medicine composition for the treatment of CGN according to claim 2, it is characterised in that the Chinese traditional medicine composition Thing is made up of the raw material of following parts by weight：15 parts of Radix Codonopsis, 13 parts of the Radix Astragali, 15 parts of the bighead atractylodes rhizome, 15 parts of Poria cocos, 16 parts of Semen Cuscutae, excessive sheep 18 parts of the leaves of pulse plants, 12 parts of psoralea corylifolia, 13 parts of the fruit of glossy privet, 12 parts of Eclipta prostrata, 15 parts of Radix Angelicae Sinensis, 16 parts of the root bark of tree peony, 12 parts of motherwort, the dried rhizome of rehmannia 13 Part, 12 parts of Radix Notoginseng, 13 parts of Radix Sangusorbae, 7 parts of radix glycyrrhizae.
- 4. the Chinese medicine composition for the treatment of CGN according to claim 2, it is characterised in that the Chinese traditional medicine composition Thing is made up of the raw material of following parts by weight：17 parts of Radix Codonopsis, 12 parts of the Radix Astragali, 16 parts of the bighead atractylodes rhizome, 20 parts of Poria cocos, 18 parts of Semen Cuscutae, excessive sheep 17 parts of the leaves of pulse plants, 13 parts of psoralea corylifolia, 12 parts of the fruit of glossy privet, 13 parts of Eclipta prostrata, 16 parts of Radix Angelicae Sinensis, 15 parts of the root bark of tree peony, 13 parts of motherwort, the dried rhizome of rehmannia 12 Part, 13 parts of Radix Notoginseng, 12 parts of Radix Sangusorbae, 8 parts of radix glycyrrhizae.
- 5. the Chinese medicine composition of the treatment CGN according to Claims 1 to 4 any one, its feature exist In any one in liniment, pulvis, capsule and decoction can be made in the Chinese medicine composition.
- 6. the preparation method of the Chinese medicine composition of the treatment CGN according to Claims 1 to 4 any one, Formulation is capsule, it is characterised in that is comprised the following steps：Step (1)：According to it is described treatment CGN Chinese medicine composition parts by weight of raw materials weigh Radix Codonopsis, the Radix Astragali, The bighead atractylodes rhizome, Poria cocos, Semen Cuscutae, barrenwort, psoralea corylifolia, the fruit of glossy privet, Eclipta prostrata, Radix Angelicae Sinensis, the root bark of tree peony, motherwort, the dried rhizome of rehmannia, Radix Notoginseng, life Garden burnet, radix glycyrrhizae；Step (2)：The Chinese medicine material weighed in step (1) is placed in 10~15min of immersion in clear water, removes debris in medicinal powder；Step (3)：Chinese medicine material obtained by step (2) is pulled out from water, is placed under natural light and dries；Dry rear moisture content control System is less than also equal to 98%；Step (4)：Step (3) dried Chinese medicine is placed in grinding machine for Chinese herb medicines and pulverized, after crossing 500~800 mesh sieves point, Sterilization processing 12~24 hours under UV light sterilization lamp；Step (5)：The herb powder that step (4) obtains is filled in capsule, that is, in the CGN that obtains medical treatment Drug Capsule.
- 7. the preparation method of the Chinese medicine composition of the treatment CGN according to Claims 1 to 4 any one, Formulation is pulvis, it is characterised in that is comprised the following steps：Step (1)：According to it is described treatment CGN Chinese medicine composition parts by weight of raw materials weigh Radix Codonopsis, the Radix Astragali, The bighead atractylodes rhizome, Poria cocos, Semen Cuscutae, barrenwort, psoralea corylifolia, the fruit of glossy privet, Eclipta prostrata, Radix Angelicae Sinensis, the root bark of tree peony, motherwort, the dried rhizome of rehmannia, Radix Notoginseng, life Garden burnet, radix glycyrrhizae；Step (2)：The Chinese medicine material weighed in step (1) is placed in 10~15min of immersion in clear water, removes debris in medicinal powder；Step (3)：Chinese medicine material obtained by step (2) is pulled out from water, is placed under natural light and dries；Dry rear moisture content control System is less than also equal to 98%；Step (4)：Step (3) dried Chinese medicine is placed in grinding machine for Chinese herb medicines and pulverized, after crossing 500~800 mesh sieves point, Sterilization processing 12~24 hours under UV light sterilization lamp；Step (5)：The herb powder that step (4) obtains is fitted into Chinese medicine net bag, that is, obtain medical treatment CGN Chinese medicine powder.
- 8. the preparation method of the Chinese medicine composition of the treatment CGN according to Claims 1 to 4 any one, Formulation is decoction, it is characterised in that is comprised the following steps：Step (1)：According to it is described treatment CGN Chinese medicine composition parts by weight of raw materials weigh Radix Codonopsis, the Radix Astragali, The bighead atractylodes rhizome, Poria cocos, Semen Cuscutae, barrenwort, psoralea corylifolia, the fruit of glossy privet, Eclipta prostrata, Radix Angelicae Sinensis, the root bark of tree peony, motherwort, the dried rhizome of rehmannia, Radix Notoginseng, life Garden burnet, radix glycyrrhizae；Step (2)：The Chinese medicine material weighed in step (1) is placed in medicine pot, and adds clear water immersion 30min, removes medicinal powder Middle debris；The addition of clear water is advisable with flooding all Chinese medicine materials, after immersion, after boiling by intense fire, slow fire heating 30~ 50 minutes, filter to obtain a decoction；Step (3)：Clear water is added in the dregs of a decoction into step (2) in marmite, the addition of clear water is advisable with flooding all dregs of a decoction, Carry out second to decoct, first boil by intense fire, then be cooked by slow fire 30 minutes, filter to obtain secondary decoction；Step (4)：Gained decoction in step (2) and step (3) is merged, pack, is placed in after naturally cooling to room temperature in refrigerator Refrigeration, refrigerated storage temperature are controlled at 0~5 DEG C, and the traditional Chinese herbal decoction for the treatment of CGN is thus made.
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Cited By (2)
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| CN112386664A (en) * | 2020-12-02 | 2021-02-23 | 青海广慈肾病医院 | Traditional Chinese medicine composition for treating chronic nephropathy and application thereof |
| CN116850221A (en) * | 2023-07-20 | 2023-10-10 | 山东省科学院菏泽分院 | Peony stamen and semen cuscutae compound and preparation method and application thereof |
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| KR101439405B1 (en) * | 2012-03-27 | 2014-09-11 | 한국과학기술연구원 | Composition for preventing or treating renal disease |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112386664A (en) * | 2020-12-02 | 2021-02-23 | 青海广慈肾病医院 | Traditional Chinese medicine composition for treating chronic nephropathy and application thereof |
| CN116850221A (en) * | 2023-07-20 | 2023-10-10 | 山东省科学院菏泽分院 | Peony stamen and semen cuscutae compound and preparation method and application thereof |
| CN116850221B (en) * | 2023-07-20 | 2024-06-11 | 山东省科学院菏泽分院 | Peony stamen and semen cuscutae compound and preparation method and application thereof |
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