CN106729409A - A kind of Chinese medicine composition for the nursing of children's indirect inguinal hernia - Google Patents
A kind of Chinese medicine composition for the nursing of children's indirect inguinal hernia Download PDFInfo
- Publication number
- CN106729409A CN106729409A CN201611236734.5A CN201611236734A CN106729409A CN 106729409 A CN106729409 A CN 106729409A CN 201611236734 A CN201611236734 A CN 201611236734A CN 106729409 A CN106729409 A CN 106729409A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- medicine composition
- children
- inguinal hernia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/235—Foeniculum (fennel)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of Chinese medicine composition for the nursing of children's indirect inguinal hernia, it is made up of the raw material of following weight portion：20 30 parts of tangerine seed, 20 30 parts of fennel seeds, 15 20 parts of Common Cissampelos Herb, 10 15 parts of Pachyrhizua angulatus, 10 15 parts of Akebia Fruit, 15 25 parts of Desmodium styracifolium, 10 20 parts of west safflower, 8 12 parts of radix ranunculi ternati, 5 10 parts of astragalus root, 5 10 parts of rhizoma curcumae longae concisa.Chinese medicine composition of the invention meets the organic conception of tcm prescription compatibility, and its good effect, instant effect has no toxic side effect, and prepares simply, cheap, has significant therapeutic effect to children's indirect inguinal hernia.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition for the nursing of children's indirect inguinal hernia.
Background technology
Children's indirect inguinal hernia is a kind of more typical abdominal external hernia disease.Childhood inguinal hernia (1-6 Sui) and juvenile hernia (7-14 can be divided into
Year).Children's indirect inguinal hernia is mostly congenital.In all of inborn defect, the illness rate highest of indirect inguinal hernia.In global model
In enclosing, the incidence of disease of children's indirect inguinal hernia of different age group is 0.8%-4.4%.Children's indirect inguinal hernia can influence disappearing for infant
Change system, the phenomenon such as declines so as to lower abdomen falling inflation, stomachache, constipation, absorption function variation, fatiguability, constitution occur, can also be because
The extruding of hernia and influence the normal development of reproductive system, various complication even threat to life can be caused when serious.
It is clinically many to be treated by operation for indirect inguinal hernia, but, the operative treatment of children's indirect inguinal hernia is very
Difficulty, because its organ and tissue are all finer, spermaduct, arteria spermatica etc. are highly prone to damage；And children can not coordinate and control
Treat, the postoperative factor such as cry and scream easily causes conjunction complication, and recurrence rate is also very high.Therefore, it should how to be treated from from the aspect of medicine
Children's indirect inguinal hernia, especially excavates the content of this respect from traditional Chinese medicine.
The content of the invention
For above-mentioned prior art, inventor combines itself clinical experience for many years, proposes a kind of for children's indirect inguinal hernia
The Chinese medicine composition of nursing, the Chinese medicine composition meets the organic conception of tcm prescription compatibility, and its good effect, instant effect is nontoxic
Side effect, prepares simply, cheap, has significant therapeutic effect to children's indirect inguinal hernia.
To achieve the above object, the present invention uses following technical proposals：
A kind of the first aspect of the present invention, there is provided Chinese medicine composition for the nursing of children's indirect inguinal hernia, is by following heavy
What the raw material of amount part was made：
Tangerine seed 20-30 parts, fennel seeds 20-30 parts, Common Cissampelos Herb 15-20 parts, Pachyrhizua angulatus 10-15 parts, Akebia Fruit 10-15 parts, it is wide
Desmodium 15-25 parts, west safflower 10-20 parts, radix ranunculi ternati 8-12 parts, astragalus root 5-10 parts, rhizoma curcumae longae concisa 5-10 parts.
Preferably, this is used for the Chinese medicine composition of children's indirect inguinal hernia nursing, is made up of the raw material of following weight portion：
It is 25 parts of tangerine seed, 25 parts of fennel seeds, 18 parts of Common Cissampelos Herb, 12 parts of Pachyrhizua angulatus, 12 parts of Akebia Fruit, 20 parts of Desmodium styracifolium, western red
Spend 15 parts, 10 parts of radix ranunculi ternati, 8 parts of astragalus root, 8 parts of rhizoma curcumae longae concisa.
In Chinese medicine composition of the invention, the pharmacological property of its each bulk drug is as follows：
Tangerine seed：Hardship, puts down.Return liver and kidney channel.Qi-regulating, dissipating bind, analgesic.For hernia pain, testiclar gall, acute mastitis breast addiction.
Fennel seeds：It is pungent, temperature.Return liver,kidney,spleen, stomach.Eliminating cold to stop pain, regulating qi-flowing for harmonizing stomach.For cold hernia stomachache, the testis swelling and hanging down of either of the testes,
Dysmenorrhoea, few abdomen crymodynia, abdominal distention, deficiency of food is vomited and diarrhoea.The warm kidney eliminating cold to stop pain of salt fennel seeds.For cold hernia stomachache, the testis swelling and hanging down of either of the testes, warp
Cold stomachache.
Common Cissampelos Herb：Sweet, hardship, temperature.Swelling and pain relieving, hemostasis, myogenic.Swollen and ache for wound, traumatic bleeding.
Pachyrhizua angulatus：It is sweet, pungent, it is cool.Returns spleen, stomach；Expelling pathogenic factors from muscles and skin is brought down a fever, and is promoted the production of body fluid to quench thirst, promoting eruption, and Shengyang Zhixie is clearing and activating the channels and collaterals, relieves the effect of alcohol
Poison.
Akebia Fruit：Hardship, trembles with fear.Return liver, courage, stomach, bladder warp；Dispersing stagnated hepatoqi, promoting blood circulation and stopping pain, dissipating bind, diuresis.
Desmodium styracifolium：It is sweet, light, it is cool.Return liver, kidney, bladder warp.Removing dampness through diuresis and removing jaundice, inducing diuresis for treating strangurtia.For jaundice urine is red, heat gonorrhea,
Urolithiasis, difficulty and pain in micturition, oedema oliguria.
West safflower：It is sweet, put down.The thoughts of returning home, Liver Channel；It is promoting blood circulation and removing blood stasis, removing pattogenic heat from the blood and toxic material from the body, resolving stagnation for tranquilization.
Radix ranunculi ternati：Sweet, acrid, warm.Return liver, lung channel.Reducing phlegm and resolving masses, removing toxicity for detumescence.For scrofula subcutaneous nodule, furuncle swelling toxin, snake
Insect bite.
Astragalus root：It is sweet, temperature.Return lung, the spleen channel.Invigorating middle warmer and replenishing QI.For treatment deficiency of vital energy weak, anorexia and loose stool.
Rhizoma curcumae longae concisa：Pungent, hardship, temperature.Returns spleen, Liver Channel.Blood-breaking, it is inducing meastruation to relieve menalgia.For chest side of body shouting pain, chest impediment and cardialgia, pain
Through Amenorrhea , Disorder lumps in the abdomen, rheumatism shoulder arm pain, tumbling and swelling.
The compatibility of Chinese medicine be particular about mutual reinforcement between, mutually make, mutual restraint between two drugs, the mutual-detoxication, the mutual inhibition, conversely, because existing not between different Chinese medicine
With compatibility relationship, therefore when using two taste above Chinese medicine, it is necessary to be allowed a choice, give full play to what mutual reinforcement between medicine mutually made
Compatibility relationship, makes the clinical effectiveness of product be significantly improved.
The present invention carries out medicine group using swelling and pain relieving, tonifying middle-Jiao and Qi, promoting qi circulation and removing obstruction in the collateral as the rules for the treatment of of children's indirect inguinal hernia
Side, in Chinese medicine composition of the invention, with tangerine seed, Common Cissampelos Herb as monarch drug in a prescription, dissipating bind, detumescence pain；Fennel seeds, Pachyrhizua angulatus, astragalus root, piece
Turmeric invigorating middle warmer and replenishing QI, promoting qi circulation and removing obstruction in the collateral, are altogether ministerial drug, are helped with Akebia Fruit, Desmodium styracifolium, west safflower, radix ranunculi ternati；All medicines share, examines
Control because of opinion, method it is vertical with card, Fang Congfa goes out, cube have evidence.
The present invention carries out compatibility by by kinds of traditional Chinese medicines, has played swelling and pain relieving, tonifying middle-Jiao and Qi, promoting the circulation of qi between medicine jointly
The effect of dredging collateral, with obvious synergistic effect, has given full play to the compatibility relationship that mutual reinforcement between mutually makes.
In sum, the selected medicinal material compatibility of we is suitable, and refining formula functionally complements each other, and with swelling and pain relieving, mends
For the purpose of middle QI invigorating, promoting qi circulation and removing obstruction in the collateral, integrate QI invigorating, promoting the circulation of qi, analgesic, it is evident in efficacy；Mutually made in the property of medicine and mutually helped, poison is secondary anti-
Should lack, take safety.
In Chinese medicine composition for the nursing of children's indirect inguinal hernia of the invention, each raw material components are one organically whole
Body, it is indispensable.Inventor has found in R＆D process, reduces any one of above-mentioned composition raw material components, or to have
The bulk drug for having the similar property of medicine is replaced to the raw material components of Chinese medicine composition of the present invention, then the overall effect of Chinese medicine composition
Effect is significant reduction；Be further added by other raw material components on the basis of Chinese medicine composition of the invention, Chinese medicine composition it is whole
Body effect does not improve significantly, or even the situation for having the whole structure reduction of Chinese medicine composition occurs.
The above-mentioned Chinese medicine composition for the nursing of children's indirect inguinal hernia directly can crush each raw material, make after being well mixed
With；Or add water to cook；Can also be prepared according to other method.
In the specific embodiment of the present invention, the system of the above-mentioned Chinese medicine composition for the nursing of children's indirect inguinal hernia
Preparation Method is：
(1) tangerine seed and Common Cissampelos Herb are mixed, is crushed, 80-100 mesh sieves are crossed, through supercritical CO2Extraction, extracting pressure is 25-
30MPa, CO2Flow is 20-25L/h, and extraction time is 1-3h, and entrainer is 95% (volume fraction) ethanol, entrainer consumption
It is the 10-15% of raw material gross weight (tangerine seed and Common Cissampelos Herb), obtains plant extract；
(2) by fennel seeds, Pachyrhizua angulatus, Akebia Fruit, Desmodium styracifolium, west safflower, radix ranunculi ternati, astragalus root, rhizoma curcumae longae concisa by weight
Grinds mix, or mixing after grinds also can, add water to cook 2-4 times, merging filtrate；
(3) filtrate of the plant extract of step (1) and step (2) is mixed, is concentrated into relative density 1.05-1.15
(50 DEG C of surveys), dries, crushes, and obtains final product.
Traditional Chinese medicine ingredients are complicated, existing water soluble ingredient in a kind of medicinal material, there is oil-soluble or Alcohol soluble composition again, and some are lived
Property composition is easily inactivated at high temperature, therefore Effective Component of Chinese Medicine is carried out by selecting suitable extracting method and extraction process
Extract and separate, can to greatest extent extract active ingredient and ensure the activity of active ingredient, so as to ensure the clinic of product
Effect.
Experiment proves that, using above-mentioned preparation method, can extract to greatest extent in Chinese medicine composition it is effective into
Divide and ensure the activity of active ingredient, so as to ensure the clinical effectiveness of product.
Application of the above-mentioned Chinese medicine composition in the pharmaceutical preparation for the nursing of children's indirect inguinal hernia is prepared is also the present invention
The scope of protection.
Second aspect present invention, there is provided a kind of pharmaceutical preparation for the nursing of children's indirect inguinal hernia, by above-mentioned Chinese traditional medicine composition
Thing and pharmaceutically acceptable auxiliary material are prepared from.
Said medicine preparation can be made various pharmaceutical dosage forms, such as pill, granule, capsule, tablet, powder or oral
Liquid etc..
The pharmaceutically acceptable auxiliary material is the customary adjuvant in pharmaceutical preparation, such as：Disintegrant, lubricant, binder
Deng；One or more preferably in glycerine, cyclodextrin, starch, sodium carboxymethylcellulose, maltodextrin.
Beneficial effects of the present invention：
The invention provides a kind of Chinese medicine composition for the nursing of children's indirect inguinal hernia, enter according to the relation of monarch
Row compatibility is used, synergy, and swollen analgesic, tonifying middle-Jiao and Qi, effect of promoting qi circulation and removing obstruction in the collateral are played jointly, is used to effect a permanent cure, its good effect,
Instant effect, has no toxic side effect, and prepares simply, cheap, has significant therapeutic effect to children's indirect inguinal hernia.
Tested by evaluation of clinical curative effect, as a result show the Chinese medicine composition for the nursing of children's indirect inguinal hernia of the invention
The total effective rate of children's indirect inguinal hernia is treated up to 100%, the curative effect of simple in Chinese medicine composition is significantly higher than, in showing this
Drug composition has obvious synergistic effect, can effectively treat children's indirect inguinal hernia；Patient is not found in whole therapeutic process
There is adverse reaction, show the Chinese medicine composition without obvious toxic and side effect, it is safe.
Specific embodiment
Below by instantiation, the present invention will be further elaborated, it should explanation, the description below be only for
The present invention is explained, its content is not defined.
Embodiment 1：
Formula：25 grams of tangerine seed, 25 grams of fennel seeds, 18 grams of Common Cissampelos Herb, 12 grams of Pachyrhizua angulatus, 12 grams of Akebia Fruit, 20 grams of Desmodium styracifolium,
15 grams of west safflower, 10 grams of radix ranunculi ternati, 8 grams of astragalus root, 8 grams of rhizoma curcumae longae concisa.
Preparation method：
(1) tangerine seed and Common Cissampelos Herb are mixed, is crushed, 80 mesh sieves are crossed, through supercritical CO2Extraction, extracting pressure is 28MPa,
CO2Flow is 22L/h, and extraction time is 2h, and entrainer is 95% (volume fraction) ethanol, and entrainer consumption is raw material gross weight
The 12% of (tangerine seed and Common Cissampelos Herb), obtains plant extract；
(2) by fennel seeds, Pachyrhizua angulatus, Akebia Fruit, Desmodium styracifolium, west safflower, radix ranunculi ternati, astragalus root, rhizoma curcumae longae concisa by weight
Grinds mix, or mixing after grinds also can, add water to cook 3 times, merging filtrate；
(3) filtrate of the plant extract of step (1) and step (2) is mixed, is concentrated into relative density 1.05-1.15
(50 DEG C of surveys), dries, crushes, and obtains final product Chinese medicine composition.
Further, above-mentioned Chinese medicine composition is mixed with auxiliary material, capsule is prepared into conventional manner, specification is
0.25g/.
Embodiment 2：
Formula：20 grams of tangerine seed, 30 grams of fennel seeds, 15 grams of Common Cissampelos Herb, 15 grams of Pachyrhizua angulatus, 10 grams of Akebia Fruit, 25 grams of Desmodium styracifolium,
10 grams of west safflower, 12 grams of radix ranunculi ternati, 5 grams of astragalus root, 10 grams of rhizoma curcumae longae concisa.
Preparation method is with embodiment 1.
Embodiment 3：
Formula：30 grams of tangerine seed, 20 grams of fennel seeds, 20 grams of Common Cissampelos Herb, 10 grams of Pachyrhizua angulatus, 15 grams of Akebia Fruit, 15 grams of Desmodium styracifolium,
20 grams of west safflower, 8 grams of radix ranunculi ternati, 10 grams of astragalus root, 5 grams of rhizoma curcumae longae concisa.
Preparation method is with embodiment 1.
Comparative example 1：
The present inventor the multi-flavor bulk drug with the close property of medicine has been carried out in R＆D process compatibility relationship investigation and
The research of drug effect, as a result finds, even if similar but different from other the bulk drug compatibility of the property of medicine between a few taste bulk drugs makes
With rear, its effect significant difference.For example：Common Cissampelos Herb in the pharmaceutical formulation of embodiment 1 is replaced with into kelp, Pachyrhizua angulatus is replaced
Fructus meliae toosendan is changed to, Akebia Fruit is replaced with into frutus cnidii, remaining is with embodiment 1；
Adopt and prepare with the following method：
(1) tangerine seed and kelp are mixed, is crushed, 80 mesh sieves are crossed, through supercritical CO2Extraction, extracting pressure is 28MPa, CO2
Flow is 22L/h, and extraction time is 2h, and entrainer is 95% (volume fraction) ethanol, and entrainer consumption is raw material gross weight (tangerine
Core and kelp) 12%, obtain plant extract；
(2) by fennel seeds, Fructus meliae toosendan, frutus cnidii, Desmodium styracifolium, west safflower, radix ranunculi ternati, astragalus root, rhizoma curcumae longae concisa by weight
The mixing of part grinds, or after mixing grinds also can, add water to cook 3 times, merging filtrate；
(3) filtrate of the plant extract of step (1) and step (2) is mixed, is concentrated into relative density 1.05-1.15
(50 DEG C of surveys), dries, crushes, and obtains final product Chinese medicine composition.
Indirect inguinal hernia animal model is set up in conventional manner, animal experiment shows, the Chinese medicine composition of the embodiment of the present invention 1
Therapeutic effect to be significantly better than comparative example 1.Illustrate that composition of the invention meets the compatibility relationship of Chinese medicine, have between each component
There is collaboration facilitation, be not the simple replacement and combination of the bulk drug with the similar property of medicine.
Comparative example 2：
The dose of each bulk drug is the mark efficacy of a drug in Chinese medicine composition, even if the medicine composition of prescription is identical, if but medicine
The consumption of thing is different, its efficacy of a drug then have size point, compatibility relationship then has the change of monarch, thus its work(cure mainly it is then each
It is different.The present inventor has carried out grinding for investigation and drug effect in R＆D process to the content of each raw material in Chinese medicine composition
Study carefully, as a result find, inappropriate raw material proportioning relation, its effect significant difference.For example：By tangerine seed, fennel fruit in embodiment 1
Fragrant weight portion is doubled, and the weight portion of Common Cissampelos Herb, Pachyrhizua angulatus is halved；The consumption of other raw materials with embodiment 1, and by embodiment 1
Method prepare.
Indirect inguinal hernia animal model is set up in conventional manner, investigates the Chinese medicine composition of the embodiment of the present invention 1 and comparative example 2
To the therapeutic effect of oophoroma, animal experiment shows, the medicine gavage mouse in comparative example 2, and it controls curative effect to indirect inguinal hernia
Fruit is significantly lower than embodiment 1, is only slightly higher than blank.
Clinical data：
1. physical data：
Accept outpatient service children's indirect inguinal hernia patient totally 60 for medical treatment, the age is minimum 6 months, maximum 12 years old.The course of disease is most long 6 years, most
It is short 3 months, because parents of hospitalized children is reluctant to be treated surgically or because the age is still small, see a doctor upon somebody's introduction in the traditional Chinese medical science.
2. diagnostic criteria：The classical symptom of children's inguinal hernia is iliac region recoverability enclosed mass, i.e., in thigh root
A prominent enclosed mass, it is changeable, protruded during body erect position, prostration or voluntarily pressed with hand just can be pushed back.Many infants
Indirect inguinal hernia enters scrotum, causes scrotum small one and large one or bilateral to increase.
3. treatment method：
Capsule prepared by oral embodiment 1, it is one-year-old within once a grain, one-year-old to three years old one time 1~2, four years old to seven
Year one time 2~3.Eight years old to 12 years old one time 4,2 times a day.15 days is 1 course for the treatment of, takes 1 course for the treatment of.
4. curative effect judging standard：
It is effective：Children's inguinal hernia symptom is fully recovered, and recovers normal；
Take a turn for the better：Children's inguinal hernia symptom mitigation, progressively takes a turn for the better；
It is invalid：Improvement standard person is not reached.
5. treatment results：
Chinese medicine composition of the invention is taken, treatment children's indirect inguinal hernia patient 60 achieves preferable clinical efficacy,
Efficient (effective+to take a turn for the better) does not find part and systemic side effects, drug safety during reaching 100%, medication.
The above, the only present invention preferably specific embodiment, but protection scope of the present invention is not limited thereto,
It is any to be familiar with those skilled in the art in the technical scope that the present invention is disclosed, technology according to the present invention scheme and its invention
Design is subject to equivalent or change, should all be included within the scope of the present invention.
Claims (7)
1. it is a kind of for children's indirect inguinal hernia nursing Chinese medicine composition, it is characterised in that be by the raw material system of following weight portion
Into：
Tangerine seed 20-30 parts, fennel seeds 20-30 parts, Common Cissampelos Herb 15-20 parts, Pachyrhizua angulatus 10-15 parts, Akebia Fruit 10-15 parts, wide money
It is careless 15-25 parts, west safflower 10-20 parts, radix ranunculi ternati 8-12 parts, astragalus root 5-10 parts, rhizoma curcumae longae concisa 5-10 parts.
2. Chinese medicine composition as claimed in claim 1, it is characterised in that be made up of the raw material of following weight portion：
25 parts of tangerine seed, 25 parts of fennel seeds, 18 parts of Common Cissampelos Herb, 12 parts of Pachyrhizua angulatus, 12 parts of Akebia Fruit, 20 parts of Desmodium styracifolium, west safflower 15
Part, 10 parts of radix ranunculi ternati, 8 parts of astragalus root, 8 parts of rhizoma curcumae longae concisa.
3. the preparation method of the Chinese medicine composition described in claim 1 or 2, it is characterised in that step is as follows：
(1) tangerine seed and Common Cissampelos Herb are mixed, is crushed, 80-100 mesh sieves are crossed, through supercritical CO2Extraction, extracting pressure is 25-
30MPa, CO2Flow is 20-25L/h, and extraction time is 1-3h, and entrainer is 95% (volume fraction) ethanol, entrainer consumption
It is the 10-15% of raw material gross weight, obtains plant extract；
(2) fennel seeds, Pachyrhizua angulatus, Akebia Fruit, Desmodium styracifolium, west safflower, radix ranunculi ternati, astragalus root, rhizoma curcumae longae concisa are worn into by weight
Powder mix, or mixing after grinds also can, add water to cook 2-4 times, merging filtrate；
(3) filtrate of the plant extract of step (1) and step (2) is mixed, is concentrated into (50 DEG C of relative density 1.05-1.15
Survey), dry, crush, obtain final product.
4. the Chinese medicine composition described in claim 1 or 2 is preparing the use in being used for the pharmaceutical preparation that children's indirect inguinal hernia is nursed
On the way.
5. it is a kind of for children's indirect inguinal hernia nursing pharmaceutical preparation, Chinese medicine composition and pharmacy as described in claim 1 or 2
Upper acceptable auxiliary material is prepared from.
6. pharmaceutical preparation as claimed in claim 5, it is characterised in that the pharmaceutically acceptable auxiliary material is disintegrant, profit
Lubrication prescription or binder.
7. pharmaceutical preparation as claimed in claim 5, it is characterised in that the formulation of the pharmaceutical preparation is pill, capsule, piece
Agent, powder, granule or oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611236734.5A CN106729409A (en) | 2016-12-28 | 2016-12-28 | A kind of Chinese medicine composition for the nursing of children's indirect inguinal hernia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611236734.5A CN106729409A (en) | 2016-12-28 | 2016-12-28 | A kind of Chinese medicine composition for the nursing of children's indirect inguinal hernia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106729409A true CN106729409A (en) | 2017-05-31 |
Family
ID=58924876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611236734.5A Pending CN106729409A (en) | 2016-12-28 | 2016-12-28 | A kind of Chinese medicine composition for the nursing of children's indirect inguinal hernia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106729409A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107715073A (en) * | 2017-11-27 | 2018-02-23 | 李光燊 | A kind of Chinese medicine composition for the nursing of children's indirect inguinal hernia |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1199634A (en) * | 1998-06-29 | 1998-11-25 | 葛炳炎 | Medicine for hernia and its preparation process and medicated deltoid belt |
| CN102018809A (en) * | 2010-12-10 | 2011-04-20 | 郑州市妇幼保健院 | Externally applied traditional Chinese medicine composition for treating umbilical hernia and umbilical hernia treating bag containing lychee seed and rhizoma cimicifugae |
| CN103830698A (en) * | 2014-02-28 | 2014-06-04 | 牛良信 | Medicine for treating inguinal hernia of children and preparation method thereof |
| CN103989796A (en) * | 2014-05-30 | 2014-08-20 | 周冠旻 | Traditional Chinese medicine for treating hernia |
| CN104436033A (en) * | 2014-11-18 | 2015-03-25 | 崔合芳 | Chinese medicinal composition for treating abdominal incisional hernia and preparation method thereof |
| CN105560515A (en) * | 2016-03-16 | 2016-05-11 | 济南正骐生物科技有限公司 | Traditional Chinese medicine patch for treating infantile umbilical hernia |
| CN105709147A (en) * | 2016-04-27 | 2016-06-29 | 王维娜 | Traditional Chinese medicine composition for treating indirect inguinal hernia as well as application method and application of traditional Chinese medicine composition |
-
2016
- 2016-12-28 CN CN201611236734.5A patent/CN106729409A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1199634A (en) * | 1998-06-29 | 1998-11-25 | 葛炳炎 | Medicine for hernia and its preparation process and medicated deltoid belt |
| CN102018809A (en) * | 2010-12-10 | 2011-04-20 | 郑州市妇幼保健院 | Externally applied traditional Chinese medicine composition for treating umbilical hernia and umbilical hernia treating bag containing lychee seed and rhizoma cimicifugae |
| CN103830698A (en) * | 2014-02-28 | 2014-06-04 | 牛良信 | Medicine for treating inguinal hernia of children and preparation method thereof |
| CN103989796A (en) * | 2014-05-30 | 2014-08-20 | 周冠旻 | Traditional Chinese medicine for treating hernia |
| CN104436033A (en) * | 2014-11-18 | 2015-03-25 | 崔合芳 | Chinese medicinal composition for treating abdominal incisional hernia and preparation method thereof |
| CN105560515A (en) * | 2016-03-16 | 2016-05-11 | 济南正骐生物科技有限公司 | Traditional Chinese medicine patch for treating infantile umbilical hernia |
| CN105709147A (en) * | 2016-04-27 | 2016-06-29 | 王维娜 | Traditional Chinese medicine composition for treating indirect inguinal hernia as well as application method and application of traditional Chinese medicine composition |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107715073A (en) * | 2017-11-27 | 2018-02-23 | 李光燊 | A kind of Chinese medicine composition for the nursing of children's indirect inguinal hernia |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20190328817A1 (en) | Traditional chinese medicine healthcare preparation for fat elimination and weight reduction | |
| CN101249235B (en) | Chinese medicine for curing esophagus cancer and method of preparing the same | |
| CN100528204C (en) | Medicament for treating children's infantile malnutrition symptom | |
| CN102106965B (en) | Composition for treating acute injury of soft tissue and application thereof | |
| CN103933450A (en) | Traditional Chinese medicine composition for preventing or/and treating gastrointestinal diseases and preparation method of composition | |
| CN106994141A (en) | It is a kind of to treat Chinese medicine composition of constipation and preparation method thereof | |
| CN106729409A (en) | A kind of Chinese medicine composition for the nursing of children's indirect inguinal hernia | |
| CN100333742C (en) | Chinese materia medica preparation for curing fracture and traumatic injury | |
| CN102416144A (en) | Chinese medicine for treating infantile convulsions | |
| CN101264155A (en) | Medicine for treatment of piles and preparation method thereof | |
| CN101647985B (en) | Medicament composition for treating psoriasis | |
| CN101468173B (en) | Chinese medicinal composition for treating children's indigestion and preparation method thereof | |
| CN109275903A (en) | Sexual health food suitable for male and female | |
| CN103446387B (en) | Traditional Chinese medicine composition for treating hyperthyroidism and preparation method thereof | |
| CN107715073A (en) | A kind of Chinese medicine composition for the nursing of children's indirect inguinal hernia | |
| CN103212030B (en) | Traditional Chinese medicine for treating liver depression type hyperplasia of mammary glands and preparation method thereof | |
| CN105535783B (en) | A kind of drug and preparation method thereof for breast feeding women's delaactation | |
| CN116251133B (en) | Pharmaceutical composition and traditional Chinese medicine preparation for treating rheumatism and rheumatoid diseases by using sialon bone | |
| CN108653497A (en) | A kind of Chinese medicine composition for treating oophoroma | |
| CN102100804B (en) | Snore relieving composite and preparation method thereof | |
| CN105265786A (en) | Compound feed for cows and preparation method thereof | |
| CN1318042C (en) | Application of barbat skullcap in preparing medication for treating diabetes | |
| CN104398704A (en) | Traditional Chinese medicine composition for treating stomach cancer and preparation method thereof | |
| CN102631496A (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue | |
| CN103800660A (en) | Traditional Chinese medicine for treating parasitophobia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170531 |