CN104398704A - Traditional Chinese medicine composition for treating stomach cancer and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating stomach cancer and preparation method thereof Download PDFInfo
- Publication number
- CN104398704A CN104398704A CN201410792606.3A CN201410792606A CN104398704A CN 104398704 A CN104398704 A CN 104398704A CN 201410792606 A CN201410792606 A CN 201410792606A CN 104398704 A CN104398704 A CN 104398704A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- parts
- medicine composition
- preparation
- gastric cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention belongs to the field of medicines and relates to a pharmaceutic preparation for treating stomach cancer, particularly to a traditional Chinese medicine composition for treating stomach cancer and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following Chinese herbs in parts by weight: 30-50 parts of elecampane, 30-60 parts of hedyotis diffusa, 25-40 parts of common andrographis, 20-40 parts of frankincense,15-30 parts of pseudo-ginseng, 15-30 parts of tribulus terrestris, 10-20 parts of curcuma zedoary, 5-15 parts of cocklebur fruit and 5-15 parts of pericarpium citri reticulatae. The traditional Chinese medicine composition has an obvious effect for treating stomach cancer, is free of toxic or side effects, has an effective rate and a cure rate of 94% and 70% respectively, and opens a new chapter for treating stomach cancer for the prior art; in addition, stomach cancer is not prone to relapse after being cured.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of Chinese medicine preparation for the treatment of gastric cancer.
Background technology
Gastric cancer is a kind of common malignant disease, is the healthy modal malignant tumor of digestive tract of harm humans.China belongs to high incidence area of gastric cancer, occupy the first place of all kinds of tumor at its sickness rate of China, about have 170,000 people to die from gastric cancer every year, almost close to 1/4 of whole mortality of malignant tumors number, and annual also have more than 20,000 new Patients with Gastric Cancer to generate, serious threat people's health.Because gastric cancer onset is comparatively hidden, the patients with gastric cancer major part of current domestic clinical definite all belongs to progressive stage, and the Patients with Gastric Cancer of early discovery is less than 50%.Doctor's Chinese effect of advanced gastric carcinoma is unsatisfactory, domestic document announcement, and 5 years survival rates of advanced gastric carcinoma only about 15%, foreign data also only has 5 40%.Often following methods is adopted at present: (1) surgical radical treatment: effective Therapeutic Method of radical cure gastric cancer is still based on surgical operation at present in treatment gastric cancer, because great majority in the patients with gastric cancer that China is medical belong to middle and advanced stage, cell transfer makes 50% patient to carry out excision, for such patient, within postoperative 5 years, survival rate also only has 20%-30%.(2) intravenous drip chemotherapy: application Low Dose Continuous instillation 5-fluorouracil treatment gastric cancer, achieves good curative effect and attract wide attention.But continuous intravenous dripping is compared with conventional intravenous drip, larger to digestive tract mucosal injury.(3) interventional therapy: for can the patients with advanced gastric cancer of radical resection, surgery is preoperative, postoperative can implement intra-arterial infusion chemotherapy; To can not the patients with advanced gastric cancer of radical resection, also corresponding interventional therapy can be selected.(4) systemic chemotherapy: chemotherapeutics unavoidably enters other Organ and tissue with blood flow, not only causes the waste of medicine, also causes certain harm to other histoorgan.In addition, because chemotherapeutics is by intravenously administrable, medicine all can produce certain effect to each organ of whole body, and toxicity is larger.As can be seen here, in the treatment of gastric cancer, operation, chemotherapy are still the main method for the treatment of gastric cancer at present.But operation can damage internal organs organ, causes wound hemorrhage; Lacking selectivity, toxic and side effects is comparatively large, occurs many untoward reaction such as anorexia, pain, the reduction of blood item index, and has damage body's immunity, well can not improve the life quality of Patients with Gastric Cancer.
Chinese medicine, not only can the immunologic function of enhancing body as the rarity of motherland, and can play antitumaous effect, prevents recurrence and transfer.Therefore, if the Chinese medicine preparation of effectively treatment gastric cancer can be developed, tool is of great significance.The present invention is by a large amount of experimentatioies, have developed a kind of Chinese medicine composition effectively can treating gastric cancer, pharmacodynamics and clinical trial results all show that the effect of traditional Chinese medicine composition for treating gastric cancer of the present invention is very remarkable, and according to actual needs, various oral formulations can be made into according to the common process of this area.
Summary of the invention
The present invention is from the rule for the treatment of of Chinese traditional treatment gastric cancer, through development test, by Polyporus, Poria, Caulis Sargentodoxae, Rhizoma Acori Graminei, Spica Prunellae, Rhizoma Alismatis, Rhizoma Polygoni Cuspidati, Herba Agrimoniae, Radix Codonopsis, Fructus Corni, Medulla Junci, Flos Albiziae, Semen Vaccariae, Herba Plantaginis, through pulverizing, processing, extract, make a kind of effective Chinese medicine preparation for the treatment of gastric cancer.
On the one hand, the invention provides a kind of Chinese medicine composition for the treatment of gastric cancer, be made up of the Chinese medicine of following weight portion: Polyporus 20-40 part, Poria 15-25 part, Caulis Sargentodoxae 10-30 part, Rhizoma Acori Graminei 5-15 part, Spica Prunellae 5-15 part, Rhizoma Alismatis 10-30 part, Rhizoma Polygoni Cuspidati 10-30 part, Herba Agrimoniae 5-15 part, Radix Codonopsis 10-30 part, Fructus Corni 10-30 part, Medulla Junci 5-15 part, Flos Albiziae 5-15 part, Semen Vaccariae 10-30 part, Herba Plantaginis 5-15 part.
In a preferred embodiment, described Chinese medicine composition is preferably formed by the Chinese drug preparation of following weight portion: Polyporus 40 parts, 15 parts, Poria, Caulis Sargentodoxae 30 parts, Rhizoma Acori Graminei 5 parts, Spica Prunellae 15 parts, Rhizoma Alismatis 10 parts, Rhizoma Polygoni Cuspidati 30 parts, Herba Agrimoniae 5 parts, Radix Codonopsis 30 parts, Fructus Corni 10 parts, Medulla Junci 15 parts, Flos Albiziae 5 parts, Semen Vaccariae 30 parts, Herba Plantaginis 5 parts.
In another preferred embodiment, described Chinese medicine composition is preferably formed by the Chinese drug preparation of following weight portion: Polyporus 20 parts, 25 parts, Poria, Caulis Sargentodoxae 10 parts, Rhizoma Acori Graminei 15 parts, Spica Prunellae 5 parts, Rhizoma Alismatis 30 parts, Rhizoma Polygoni Cuspidati 10 parts, Herba Agrimoniae 15 parts, Radix Codonopsis 10 parts, Fructus Corni 30 parts, Medulla Junci 5 parts, Flos Albiziae 15 parts, Semen Vaccariae 10 parts, Herba Plantaginis 15 parts.
In a further preferred embodiment, described Chinese medicine composition is preferably formed by the Chinese drug preparation of following weight portion: Polyporus 30 parts, 20 parts, Poria, Caulis Sargentodoxae 20 parts, Rhizoma Acori Graminei 10 parts, Spica Prunellae 10 parts, Rhizoma Alismatis 20 parts, Rhizoma Polygoni Cuspidati 20 parts, Herba Agrimoniae 10 parts, Radix Codonopsis 20 parts, Fructus Corni 20 parts, Medulla Junci 10 parts, Flos Albiziae 10 parts, Semen Vaccariae 20 parts, Herba Plantaginis 10 parts.
On the other hand, the invention provides the preparation method of described Chinese medicine composition, comprise the following steps:
Polyporus, Poria, Caulis Sargentodoxae, Rhizoma Acori Graminei, Spica Prunellae, Rhizoma Alismatis, Rhizoma Polygoni Cuspidati, Herba Agrimoniae, Radix Codonopsis, Fructus Corni, Medulla Junci, Flos Albiziae, Semen Vaccariae, Herba Plantaginis is taken according to proportioning, add the water of 8-15 times amount wherein, decoct 3 times, each 1-3 hour, collecting decoction, filter, filtrate is condensed into the clear paste (80 DEG C) that relative density is 1.15-1.25, add ethanol to alcohol content 60-80% (v/v), stir, leave standstill 12-24 hour, filter, decompression filtrate recycling ethanol, to obtain final product.
In a preferred embodiment, the preparation method of Chinese medicine composition of the present invention comprises the following steps:
Take Polyporus by formula ratio, Poria, Caulis Sargentodoxae, Rhizoma Acori Graminei, Spica Prunellae, Rhizoma Alismatis, Rhizoma Polygoni Cuspidati, Herba Agrimoniae, Radix Codonopsis, Fructus Corni, Medulla Junci, Flos Albiziae, Semen Vaccariae, Herba Plantaginis get the raw materials ready, add 12 times of water, decoct 3 times, each 2 hours, collecting decoction, filter, filtrate is condensed into the clear paste (80 DEG C) that relative density is 1.15-1.25, add ethanol to alcohol content 80% (v/v), stir, leave standstill 24 hours, filter, decompression filtrate recycling ethanol, to obtain final product.
In a preferred embodiment, according to the preparation method of this area routine, by adding appropriate adjuvant, the present composition can be made the preparations such as granule, tablet, capsule, soft extract, pill, medicinal tea, powder, drop pill.
Described adjuvant comprises the general conventional adjuvant of various medical standards, such as diluent, binding agent, disintegrating agent, lubricant, sweeting agent etc.
Again on the one hand, present invention also offers the purposes of described Chinese medicine composition in preparation treatment gastric cancer medicament.The instructions of taking of Chinese medicine composition of the present invention: take 2 day, sooner or later after meal respectively once.Treat the course for the treatment of: within 30 days, be 1 course for the treatment of, the lighter 2-3 can cure a course for the treatment of, and severe one 3-6 the course for the treatment of can cure, and not easily recurs after healing.Pharmacodynamics and clinical test results show, the successful of traditional Chinese medicine composition for treating gastric cancer of the present invention, has no side effect, not easily recur more, effective percentage 95.0%, cure rate 73.8%.
The advantage of Chinese medicine composition of the present invention:
Above 14 taste Chinese medicines in Chinese medicine composition of the present invention share, and play the merit of replenishing QI to invigorate the spleen, blood circulation promoting and blood stasis dispelling, spleen invigorating removing food stagnancy altogether, for the treatment of gastric cancer.In addition, Chinese medicine composition preparation technology of the present invention is simple, and have no side effect, patient compliance is higher, has good application prospect and profound significance in curing gastric cancer.
Detailed description of the invention
Technical scheme of the present invention is further described by following embodiment.It is pointed out that following explanation is only illustrating the technical scheme that application claims is protected, any restriction not to these technical schemes.The content that protection scope of the present invention is recorded with appended claims is as the criterion.
embodiment 1
Composition:
Polyporus 40g, Poria 15g, Caulis Sargentodoxae 30g, Rhizoma Acori Graminei 5g, Spica Prunellae 15g, Rhizoma Alismatis 10g, Rhizoma Polygoni Cuspidati 30g, Herba Agrimoniae 5g, Radix Codonopsis 30g, Fructus Corni 10g, Medulla Junci 15g, Flos Albiziae 5g, Semen Vaccariae 30g, Herba Plantaginis 5g.
Method for making:
Take Polyporus by formula ratio, Poria, Caulis Sargentodoxae, Rhizoma Acori Graminei, Spica Prunellae, Rhizoma Alismatis, Rhizoma Polygoni Cuspidati, Herba Agrimoniae, Radix Codonopsis, Fructus Corni, Medulla Junci, Flos Albiziae, Semen Vaccariae, Herba Plantaginis get the raw materials ready, add 15 times of water, decoct 3 times, each 1.5 hours, collecting decoction, filter, filtrate is condensed into the clear paste (80 DEG C) that relative density is 1.15-1.25, add ethanol to alcohol content 60% (v/v), stir, leave standstill 18 hours, filter, decompression filtrate recycling ethanol, to obtain final product.
embodiment 2
Composition:
Polyporus 20g, Poria 25g, Caulis Sargentodoxae 10g, Rhizoma Acori Graminei 15g, Spica Prunellae 5g, Rhizoma Alismatis 30g, Rhizoma Polygoni Cuspidati 10g, Herba Agrimoniae 15g, Radix Codonopsis 10g, Fructus Corni 30g, Medulla Junci 5g, Flos Albiziae 15g, Semen Vaccariae 10g, Herba Plantaginis 15g.
Method for making:
Take Polyporus by formula ratio, Poria, Caulis Sargentodoxae, Rhizoma Acori Graminei, Spica Prunellae, Rhizoma Alismatis, Rhizoma Polygoni Cuspidati, Herba Agrimoniae, Radix Codonopsis, Fructus Corni, Medulla Junci, Flos Albiziae, Semen Vaccariae, Herba Plantaginis get the raw materials ready, add 8 times of water, decoct 3 times, each 3 hours, collecting decoction, filter, filtrate is condensed into the clear paste (80 DEG C) that relative density is 1.15-1.25, add ethanol to alcohol content 70% (v/v), stir, leave standstill 12 hours, filter, decompression filtrate recycling ethanol, to obtain final product.
embodiment 3
Composition:
Polyporus 30g, Poria 20g, Caulis Sargentodoxae 20g, Rhizoma Acori Graminei 10g, Spica Prunellae 10g, Rhizoma Alismatis 20g, Rhizoma Polygoni Cuspidati 20g, Herba Agrimoniae 10g, Radix Codonopsis 20g, Fructus Corni 20g, Medulla Junci 10g, Flos Albiziae 10g, Semen Vaccariae 20g, Herba Plantaginis 10g.
Method for making:
Take Polyporus by formula ratio, Poria, Caulis Sargentodoxae, Rhizoma Acori Graminei, Spica Prunellae, Rhizoma Alismatis, Rhizoma Polygoni Cuspidati, Herba Agrimoniae, Radix Codonopsis, Fructus Corni, Medulla Junci, Flos Albiziae, Semen Vaccariae, Herba Plantaginis get the raw materials ready, add 12 times of water, decoct 3 times, each 2 hours, collecting decoction, filter, filtrate is condensed into the clear paste (80 DEG C) that relative density is 1.15-1.25, add ethanol to alcohol content 80% (v/v), stir, leave standstill 24 hours, filter, decompression filtrate recycling ethanol, to obtain final product.
the test of pesticide effectiveness research of embodiment 4 Chinese medicine composition of the present invention
The present invention has carried out the experimentation of gastric cancer in nude mice subcutaneous transplantation tumor to Chinese medicine composition prepared by above-described embodiment 1-3.
1. experiment material
1.1 cells and laboratory animal
BALB/c nude mice (Shanghai Si Laike animal center, the quality certification number: SCXK (Shanghai) 2007-0005) 32, male and female half and half, 4 week age, body weight 18-22g; Raise under SPF level environment, ultraviolet radiation is regularly carried out in indoor, the equal strict sterilization of mouse cage, bedding and padding, drinking-water.
5-FU injection: 25mg/ml, is provided by Tianjin KingYork Amino Acid Co., Ltd., lot number: 1109161.Getting 1ml 5-FU solution adds in 9ml normal saline, now with the current.
1.2 reagent and equipment
RPMI-1640 culture fluid is purchased from Gibco company; Calf serum is purchased from Hangzhou Ilex purpurea Hassk.[I.chinensis Sims company; Trypsin is purchased from Biosharp company; SPF Animal House: Jiangsu TCM Hospital animal experimental center SPF Animal House.
2. experimental technique
2.1 Modling model
The RPMI-1640 cellar culture of people's gastric cancer cell line MGC-803 containing 10% calf serum, digestion is re-suspended cell also, every nude inoculation 0.2ml cell suspension, 5 × 10
6individual cell.After 2 weeks, on the right side of nude mice, oxter occurs that diameter is the scleroma of 5mm-7mm, and modeling success, enters experiment.
2. 2 animal groupings, administration:
32 nude mices are divided at random: negative control group (NS group), positive controls (5-FU group), embodiment 1-3 Chinese medicine composition group.Concrete administering mode sees the following form 1.Continuous use 10 days, next day puts to death tumor bearing nude mice, cuts open tumor and weighs.
Table 1 medicine composition and administering mode
| Group | Medicine forms | Dosage | Administration volume | Administration number of times |
| Negative control | Normal saline | 2.5mg/kg | 0.2ml/10g | 1 times/day |
| Positive control | Fluorouracil | 2.5mg/kg | 0.2ml/10g | 1 times/day |
| Medicine group 1 | Embodiment 1 compositions | 50g/kg | 0.2ml/10g | 1 times/day |
| Medicine group 2 | Embodiment 2 compositions | 50g/kg | 0.2ml/10g | 1 times/day |
| Medicine group 3 | Embodiment 3 compositions | 50g/kg | 0.2ml/10g | 1 times/day |
2. 3 antitumous effects are observed
1. observation item: in execution all animals on the 11st of experiment, dissect and peel off tumor body, claim tumor quality.
2. calculate tumor control rate according to tumor weight:
Measure tumor weight and calculate tumor control rate:
Suppression ratio (%)=(the average tumor weight of 1-administration group average tumor weight/matched group) × 100%.
Criterion: tumor control rate >30%, through the statistical procedures person that has notable difference for there being antitumor action.
2. 4 statistical dispositions
Adopt SPSS 13.0 statistical software to carry out statistical procedures, after homogeneity test of variance, compare between group and check with t.
3. experimental result
3.1 nude mice upgrowth situations
Each group of Xenografts in nude mice success rate is 100%, after tumor planting about 2 weeks, and subcutaneous obvious visual tumors, diameter about 5 7mm, enters experiment.Continue to increase with posterior tuberosity body, each group growth of xenografted differs, and differs in size, and becoming thin all does not appear in each group nude mice, dead.
3.2 Chinese medicine compositions are on the impact of MGC-803 cell Xenografts in nude mice tumor weight
After putting to death all nude mices, stripping tumor is weighed.After administration, each group Mouse Weight comparatively has increased slightly before administration, no significant difference (P>0. 05) between group.Tumor body body weight has remarkable group difference, and compared with negative control group, the Chinese medicine composition group of embodiment of the present invention 1-3 all obviously can suppress the growth of Xenografts in nude mice, and tumour inhibiting rate is respectively 66.7%, 67.4% and 70.5%.The results are shown in Table 2:
Table 2 Chinese medicine composition of the present invention is on the impact (mm of Xenografts in nude mice tumor weight
3)
the Clinical observation of embodiment 5 Chinese medicine composition of the present invention
The clinical observation of Drug therapy gastric cancer of the present invention:
1, data is treated:
Get clinical identification be gastric cancer patient 80 example, wherein man 45 example, female 35 example, the age 45-65 year.Above patient is all advanced gastric carcinoma by CT and check pathological section.
2, diagnostic criteria:
Stomach sharp ache, can touch and see that bag is fast, nausea and vomiting, abdominal distention, feed is few, stomach occurs scorching hot, and constipation due to dry stool, has blood in stool greatly, and food difficulty is swallowed, distension and fullness in the abdomen, belch, or pharynx thing unfavorable, time have retrosternal pain, uncomfortable in chest, or spue after food, thirst with desire to drink; yellow urine, pallor of breathing hard, puffiness of the face and dropsy of the feet; become thin, weak, spirit is poor.
3, Therapeutic Method:
Take Chinese medicine composition prepared by the embodiment of the present invention 3, take 2 day, early, after supper each once.
4, the course for the treatment of is treated: within 30 days, be 1 course for the treatment of.
5, efficacy assessment standard
Effective: pain relief, appetite increases, and spirit is recovered to some extent, tumor regression or be not in progress, and the state of an illness can be stablized.
Take a turn for the better: pain disappears, and tumor obviously reduces, appetite is normal, and spirit takes a turn for the better, and time has repeatedly, still needs treatment.
Recovery from illness: tumor body disappears, pain disappears, and appetite is normal, energetic, recovers to work normally.
Invalid: symptom art alleviates, the state of an illness continues to worsen.
6, therapeutic outcome
The above-mentioned patients with gastric cancer of Chinese medicine composition Drug therapy through preparing by the embodiment of the present invention 3, through treating 3 courses for the treatment of, 59 examples of wherein fully recovering, take a turn for the better 13 examples, effective 4 examples, invalid 4 examples, effective percentage 95.0%, cure rate 73.8%, inefficiency 5.0%.
Model case
1, poplar, man, 45 years old, in February, 2010 is diagnosed as gastric cancer, according to instructions of taking of the present invention, take 2 day, early, after supper each once, after taking 2 courses for the treatment of of Chinese medicine composition of the embodiment of the present invention 3, patient's stomach pain, scorching hot, distension and fullness in the abdomen, belch, the symptoms such as pallor of breathing hard alleviate to some extent.After continuing to take 3 courses for the treatment of, above-mentioned symptom all disappears, and does not exist through CT examination tumor, follows up a case by regular visits to and does not recur for 1 year.
2, China certain, female, 53 years old, in July, 2009 is diagnosed as gastric cancer, according to instructions of taking of the present invention, take 2 day, early, after supper each once, after taking 2 courses for the treatment of of medicine prepared by the embodiment of the present invention 3, epigastric distending pain, have blood in stool, the symptom such as puffiness of the face and dropsy of the feet takes a turn for the better to some extent, take 3 courses for the treatment of continuously by above-mentioned instructions of taking, above-mentioned symptom all disappears, CT examination result display tumor disappears, follows up a case by regular visits to and does not recur for 1 year.
3, the Qin, female, 57 years old, in October, 2010 is diagnosed as gastric cancer, according to instructions of taking of the present invention, takes 2 day, early, after supper each once, after taking 3 courses for the treatment of of medicine prepared by the embodiment of the present invention 3, patient's stomach is scorching hot, have a stomachache, have blood in stool, distension and fullness in the abdomen, the symptom such as to breathe hard take a turn for the better gradually, continues to take 2 courses for the treatment of continuously, the above-mentioned symptom of the Qin all disappears, CT examination result display tumor does not exist, and physical recovery is normal, follows up a case by regular visits to and does not recur for 1 year.
Content of the present invention merely illustrates some claimed specific embodiments; one of them or more described technical characteristic can be combined with arbitrary one or more technical scheme in technical scheme; these technical schemes obtained through combination also in the application's protection domain, just as these technical schemes obtained through combination in the disclosure of invention concrete record.
Claims (7)
1. treat the Chinese medicine composition of gastric cancer for one kind, it is characterized in that, it is prepared from by the Chinese crude drug of following weight portion: Radix Aucklandiae 30-50, Herba Hedyotidis Diffusae 30-60, Herba Andrographis 25-40, Olibanum 20-40, Radix Notoginseng 15-30, Fructus Tribuli 15-30, Rhizoma Curcumae 10-20, Fructus Xanthii 5-15, Pericarpium Citri Reticulatae 5-15.
2. Chinese medicine composition according to claim 1, it is preferably prepared from by the Chinese crude drug of following weight portion: the Radix Aucklandiae 40, Herba Hedyotidis Diffusae 45, Herba Andrographis 35, Olibanum 30, Radix Notoginseng 25, Fructus Tribuli 25, Rhizoma Curcumae 15, Fructus Xanthii 10, Pericarpium Citri Reticulatae 10.
3. the preparation method of the Chinese medicine composition described in a claim 1-2, it is characterized in that, concrete steps are as follows: take the Radix Aucklandiae by formula ratio, Herba Hedyotidis Diffusae, Herba Andrographis, Olibanum, Radix Notoginseng, Fructus Tribuli, Rhizoma Curcumae, Fructus Xanthii, Pericarpium Citri Reticulatae nine taste Chinese medicine, add the water of 6-12 times amount wherein, decoct three times, each 1-3 hour, collecting decoction, filter, filtrate is condensed into the clear paste (80 DEG C) that relative density is 1.10-1.25, add ethanol to alcohol content 60-80% (v/v), stir, leave standstill 12-24 hour, filter, decompression filtrate recycling ethanol, obtain.
4. the preparation method of Chinese medicine composition according to claim 3, it is characterized in that, concrete steps are as follows: take the Radix Aucklandiae by formula ratio, Herba Hedyotidis Diffusae, Herba Andrographis, Olibanum, Radix Notoginseng, Fructus Tribuli, Rhizoma Curcumae, Fructus Xanthii, Pericarpium Citri Reticulatae get the raw materials ready, add the water of 10 times amount wherein, decoct three times, each 1.5 hours, collecting decoction, filter, filtrate is condensed into the clear paste (80 DEG C) that relative density is 1.10-1.15, add ethanol to containing alcohol 60% (v/v), stir, leave standstill 18 hours, filter, decompression filtrate recycling ethanol, to obtain final product.
5. the pharmaceutical preparation containing Chinese medicine composition according to claim 1, it is characterized in that, described Chinese medicine composition and pharmaceutically acceptable adjuvant are prepared into suitable pharmaceutical preparation, such as tablet, granule, capsule, soft extract, pill, medicinal tea, powder, drop pill etc.
6. pharmaceutical preparation according to claim 4, is characterized in that, described pharmaceutical preparation is preferably tablet or granule.
7. the application of the Chinese medicine composition described in claim 1-2 in the medicine of preparation treatment gastric cancer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410792606.3A CN104398704A (en) | 2014-12-19 | 2014-12-19 | Traditional Chinese medicine composition for treating stomach cancer and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410792606.3A CN104398704A (en) | 2014-12-19 | 2014-12-19 | Traditional Chinese medicine composition for treating stomach cancer and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104398704A true CN104398704A (en) | 2015-03-11 |
Family
ID=52636413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410792606.3A Pending CN104398704A (en) | 2014-12-19 | 2014-12-19 | Traditional Chinese medicine composition for treating stomach cancer and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104398704A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106039101A (en) * | 2016-05-28 | 2016-10-26 | 蒋保珍 | Traditional Chinese medicine composition for treating phlegm stagnation type stomach cancer |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009134036A2 (en) * | 2008-04-28 | 2009-11-05 | (주)휴럼 | A mushroom mycelium fermentate using acanthopanax bark as substrate, useful in the prevention and treatment of gastritis, and a pharmaceutical using the extract of said fermentate |
| CN103816484A (en) * | 2014-03-07 | 2014-05-28 | 杨洪霞 | Traditional Chinese medicine composition for treating stomach cancer and preparation method thereof |
-
2014
- 2014-12-19 CN CN201410792606.3A patent/CN104398704A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009134036A2 (en) * | 2008-04-28 | 2009-11-05 | (주)휴럼 | A mushroom mycelium fermentate using acanthopanax bark as substrate, useful in the prevention and treatment of gastritis, and a pharmaceutical using the extract of said fermentate |
| CN103816484A (en) * | 2014-03-07 | 2014-05-28 | 杨洪霞 | Traditional Chinese medicine composition for treating stomach cancer and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张子理: "中医药辨证治疗胃癌前期病变临床研究", 《甘肃中医》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106039101A (en) * | 2016-05-28 | 2016-10-26 | 蒋保珍 | Traditional Chinese medicine composition for treating phlegm stagnation type stomach cancer |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101491663B (en) | Traditional Chinese medicine composition for treating various cancer | |
| CN101249235B (en) | Chinese medicine for curing esophagus cancer and method of preparing the same | |
| CN102284049B (en) | A kind ofly alleviate compound Chinese medicinal preparation of chemicotherapy toxicity and uses thereof | |
| CN100490789C (en) | Enteric coated Chinese medicinal capsule for treating cancer and preparation method thereof | |
| CN104352608B (en) | A kind of benefiting QI for activating blood circulation, hard masses softening and resolving, the Chinese medicine and preparation method thereof of removing toxic substances pain relieving | |
| CN102861284B (en) | Traditional Chinese medicine compound preparation for treating non-small cell lung cancer and preparation method thereof | |
| CN102008650B (en) | Compound traditional Chinese medicine preparation for treating tumors and preparation method thereof | |
| CN102225181B (en) | Medicament for treating benign prostatic hyperplasia disease and preparation method thereof | |
| CN102861193B (en) | Traditional Chinese medicine composition for treating gastric cancer | |
| CN103341150B (en) | Traditional Chinese medicine preparation for treating chronic gastritis | |
| CN103386078A (en) | Application of traditional Chinese medicinal composition in preparation of medicines for treating colon cancer | |
| CN101091769B (en) | Medicine for treating and preventing esophagus cancer and gastric cancer, and preparation method | |
| CN105213974A (en) | One treats lymphadenomatous Chinese medicine composition and application thereof | |
| CN103933450A (en) | Traditional Chinese medicine composition for preventing or/and treating gastrointestinal diseases and preparation method of composition | |
| CN103908611A (en) | Traditional Chinese medicine preparation for treating colon cancer and preparation method of traditional Chinese medicine preparation | |
| CN108186794B (en) | Traditional Chinese medicine composition for treating lung cancer and preparation method and application thereof | |
| CN102028924A (en) | Medicinal composition for late gastric cancer | |
| CN104524163B (en) | A kind of Chinese medicine composition and preparation method for the treatment of chronic bronchitis and merging pulmonary carcinoma | |
| CN104324316A (en) | Application of traditional Chinese medicine composition to prepare medicines treating colorectal cancer | |
| CN104398704A (en) | Traditional Chinese medicine composition for treating stomach cancer and preparation method thereof | |
| CN105770691A (en) | Medicinal preparation for treating cervical cancer and application thereof | |
| CN104888128A (en) | Traditional Chinese medicine composition for treatment of cancers | |
| CN108653497A (en) | A kind of Chinese medicine composition for treating oophoroma | |
| CN107019771A (en) | A kind of antineoplastic Chinese medicine composition | |
| CN105943579A (en) | Pharmaceutical composition for treating gastric cancer and preparation method of pharmaceutical composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150311 |