CN106361938A - Traditional Chinese medicine composition for preventing and treating chicken infectious anemia and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for preventing and treating chicken infectious anemia and preparation method and application thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention provides a traditional Chinese medicine composition for preventing and treating chicken infectious anemia. The traditional Chinese medicine composition is prepared from, by weight, 300+/-10 parts of milkvetch roots, 100+/-10 parts of radix angelica sinensis, 100+/-10 parts of herba cynomorii, 100+/-10 parts of radix achyranthis bidentatae, 50+/-5 parts of herba cistanche, 100+/-10 parts of fructus psoraleae, 100+/-10 parts of radix codonopsis, 50+/-5 parts of poria cocos, 100+/-10 parts of common yam rhizomes, 80+/-10 parts of fructus jujubae, 80+/-10 parts of caulis spatholobi and 50+/-5 parts of prepared licorice roots. The invention further provides a preparation method and application of the traditional Chinese medicine composition. Tests show that the traditional Chinese medicine composition has the effects of invigorating qi and blood, tonifying the heart and the spleen, reinforcing the kidney to replenish the essence and strengthening the body resistance to eliminate pathogenic factors and can effectively prevent and treat the chicken infectious anemia.
Description
Technical field
The invention belongs to veterinary drug technical field is and in particular to a kind of Chinese medicine composition for preventing and treating chicken infectious anemia
And its preparation method and application.
Background technology
Infectious anemia also known as Chicken infectious anemia, also known as blue wing disease, hemorrhagic-syndrome or anemicus dermatitis syndrome, be
The Immune Profile In Chicks inhibition disease being caused by Chicken Anemia Virus (CAV).Clinic is with aplastic anemia, total lymphoid tissue
Atrophy, subcutaneous and hemorrhage of muscle are characterized, and chicken is unique host of infectious anemia virus.The chicken at various ages all can infect,
Natural infection is common in the chickling of 2～4 week old, and the chickling of different cultivars all can infection morbidity.With the increase of age in days, susceptibility
Rapid decline, broiler is more susceptible than laying hen.Infectious anemia can pass through vertical transmission and horizontal transmission, and vertical transmission is considered this
The most important route of transmission of disease, horizontal transmission can cause infection by oral cavity, digestive tract and respiratory tract approach.Chicken anaemia viruses
The immunosuppressant causing can aggravate the infection of colibacillosiss, inclusion body hepatitis, adenoviruss etc..
The unique characteristics symptom of primary disease is anemia.General morbidity in 10 days after infection, peaks for 14～16 days.Diseased chicken
Show as spirit depressed, weak, it is slow in action, beak, wattle, skin of face and visual mucosal pallor, undergrowth, under body weight
Fall, is before also shown diarrhoea on one's deathbed.Mortality rate is affected by many factors such as virus, antibacterial, host and environment, experimental infection
Mortality rate is less than 30%, and no complication, level infection will not cause high mortality.After infection, the chicken of survival in 20～28 days can be by
Gradually recover normal.Diseased chicken anemia, become thin, muscle is pale with internal organs, anemia.Liver and kidney enlargement, colour fading or faint yellow,
Blood is thin, cruor time extending.Cut open inspection is the most distinctive to be pathological changes bone marrow suppression, and femoral bone marrow is in fatty color, yellowish
Color or pink, the color of some case bone marrow is in kermesinus.Atrophy of thymus gland is modal pathological changes, in dark reddish brown, may
It is led to degenerate completely, with the growth of diseased chicken, the raising of resistance, atrophy of thymus gland is more easily observed than bone marrow lesion.Method
Not it is obvious that some case fabricius bursa volumes have reduces, fabricius bursa outer wall is translucent state it is seen that inside to family name's capsule atrophy
Pleat.Sometimes visible glandular stomach mucosal bleeding and subcutaneous and hemorrhage of muscle.If having secondary bacterial infection it is seen that gangraenosum skin
Inflammation, liver enlargement is in mottling.
Primary disease in these years brings heavy losses to China's poultry husbandry.Chang Yi local prevalence, patient's multiphase is susceptible, passes
Metachromia is strong, often results in large quantities of chicken deaths, very harmful to poultry husbandry, and the suitable antiviral antibacterials of urgent need searching are carried out specific aim and controlled
Treat, become a noticeable worldwide problem.
Doctor trained in Western medicine there is no effective curative at present, and generally available broad ectrum antibiotic controls the antibacterial secondary sense related to primary disease
Dye.Increase vitamin, trace element and aminoacid etc. in feedstuff and can slow down the state of an illness, reduce mortality rate, to the shortening course of disease and diseased chicken
Resistance to cross rehabilitation have positive role.Generally antimicrobial drug can be added in feedstuff or drinking-water prevents antibacterial secondary infection, feedstuff and drink
Add the resistances against diseases of the enhancing body such as astragalus polysaccharidess, vitamin c in water.Chinese medicine derives from animal, plant and mineral, contains
There are multiple biological effective components, wherein most of Chinese medicines are the aboundresources with natural plants as raw material, easily obtain, effect is good
Good, cheap, toxic and side effects are small, almost noresidue, no Drug resistance, free from environmental pollution.Therefore, substituted from Chinese medicine preparation
Chemical medicine, antibiotic are particularly important.
Content of the invention
In order to solve problems of the prior art, the invention provides for the Chinese medicine group preventing and treating chicken infectious anemia
Compound.
First purpose of the present invention is to provide a kind of Chinese medicine composition for preventing and treating chicken infectious anemia, described Chinese medicine
Compositionss are made up of each crude drug of following weight portion: the Radix Astragali 300 ± 10 weight portion, Radix Angelicae Sinensis 100 ± 10 weight portion, Herba Cynomorii 100
± 10 weight portions, Radix Achyranthis Bidentatae 100 ± 10 weight portion, Herba Cistanches 50 ± 5 weight portion, Fructus Psoraleae 100 ± 10 weight portion, Radix Codonopsis 100 ±
10 weight portions, Poria 50 ± 5 weight portion, Rhizoma Dioscoreae 100 ± 10 weight portion, Fructus Jujubae 80 ± 10 weight portion, Caulis Spatholobi 80 ± 10 weight
Part, Radix Glycyrrhizae Preparata 50 ± 5 weight portion.
Preferably, described Chinese medicine composition is made up of each crude drug of following weight portion: the Radix Astragali 300 weight portion, Radix Angelicae Sinensis
100 weight portions, Herba Cynomorii 100 weight portion, Radix Achyranthis Bidentatae 100 weight portion, Herba Cistanches 50 weight portion, Fructus Psoraleae 100 weight portion, Radix Codonopsis 100
Weight portion, Poria 50 weight portion, Rhizoma Dioscoreae 100 weight portion, Fructus Jujubae 80 weight portion, Caulis Spatholobi 80 weight portion, Radix Glycyrrhizae Preparata 50 weight portion.
Second object of the present invention is the preparation method providing above-mentioned Chinese medicine composition, by each component powder of formula ratio
Broken, sieve after mix and obtain final product.
Third object of the present invention is the medicine providing above-mentioned Chinese medicine composition in preparation treatment preventing and treating chicken infectious anemia
Application in thing.
Fourth object of the present invention is to provide a kind of medicine, and its effective ingredient is the Chinese medicine group described in claim 1 or 2
Compound.
Preferably, the dosage form of described medicine is powder.
Preferably, the dose of every chicken is 1-3g, once a day, the dose focusing on the chicken within 1kg is every
Chicken 1g.
In the Chinese medicine composition of the present invention: the Radix Astragali: property is sweet, taste temperature, return lung, spleen channel.There is invigorating QI to consolidate the body surface resistance, diuretic and maintain drug,
Evacuation of pus, the effect of expelling pus and promoting granulation.For diseases such as treatment deficiency of vital energy weak, anorexia and loose stool, sinking of QI of middle-JIAO, deficiency of vital energy edema, flaccidity of limbs due to deficiency of blood is yellows.
Radix Angelicae Sinensis: sweet in the mouth, pungent, bitter, warm in nature.Return liver, the heart, spleen channel.There is the effect of replenishing and activating blood, for blood deficiency.
Herba Cynomorii: warm in nature, taste: sweet.Return liver and kidney channel.There is the effect of invigorating the liver and kidney, invigorating kidney-YANG, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome.With
In insufficiency of kidney-YANG, soreness of waist and knee joint, muscles and bones is powerless, and the moon declines Sanguis Draxonis, and gas is weak to wait disease.Modern study shows Herba Cynomorii: 1, to immunologic function
Impact；2nd, remove free radical；3rd, antiplatelet aggregation；4th, there is the effect of saccharide 17-hydroxy-11-dehydrocorticosterone sample.Up-to-date medical research finds: lock
Sun can promote body cell regeneration and metabolism, strengthens immunoregulation capability.
Radix Achyranthis Bidentatae: property is bitter, taste: sweet, sour, put down.Return liver and kidney channel.There is eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome,
The effect of conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is powerless, spits blood, the disease such as epistaxis.
Herba Cistanches: warm in nature, taste: sweet, salty.Return kidney, large intestine channel: there is the effect of kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.With
In: sexual impotence, not soreness of the waist and knees, muscles and bones is powerless, dry constipation of intestines.
Fructus Psoraleae: warm in nature, taste: pungent, bitter.Return kidney, pericardium, spleen channel.There is reinforcing the kidney and supporting YANG, helping inspiration to relieve asthma, warming spleen and stopping diarrha it
Effect.For treating insufficiency of kidney-YANG；Below element deficiency and cold；Chills and pain of the waist and kness；Failure of the kidney in receiving QI；Dyspnea due to deficiency is more than；Asthenia of both the spleen and kidney；Stool chronic diarrhea etc.
Disease.
Radix Codonopsis: sweet in the mouth, mild-natured, returns spleen, lung two warp, there is invigorating the spleen and replenishing QI, strengthening spleen and tonifying lung, anticancer, blood pressure lowering, anti-hypoxia, resist
Old and feeble the effect of, the activity of superoxide dismutase with enhancing body body immunity, can be improved, strengthen the energy eliminating free radical
Power.
Poria: mild-natured, taste: sweet, light, GUIXIN, spleen, lung, kidney channel.There is the effect of promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For water
Swollen oliguria spleen eating less, have loose bowels in loose stool, irritability, the disease such as insomnia of palpitating with fear.
Rhizoma Dioscoreae: sweet in the mouth, mild-natured, return lung, spleen, kidney channel.There is strengthening the spleen and tonifying the lung, beneficial stomach kidney tonifying, reinforce the kidney beneficial essence, cure mainly
Weakness of the spleen and stomach, lassitude, inappetence, kidney qi loss etc. are demonstrate,proved.
Fructus Jujubae: sweet in the mouth, warm in nature, returns spleen, stomach.There is the effect of air making-up and spleen enlivening, nourishing blood to tranquillize the mind, for weakness of the spleen and stomach, body
Tired weak, insufficiency of vital energy and blood etc. is demonstrate,proved.
Caulis Spatholobi: warm in nature, taste: bitter, sweet.Return liver and kidney channel.There is the effect of effect blood circulation promoting and enriching, relaxing muscles and tendons and activating QI and blood in the collateral.For wind
Pain of dampness syndrome, paralysis and numbness, the disease such as blood deficiency and yellow complexion.
Radix Glycyrrhizae: mild-natured, taste is put down, enter the heart, lung, spleen, stomach.There are invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription
The effect of.
Chinese veterinarian is the Dynamic medical stressing syndrome characteristics, is that the essence of adjustment body internal organs function equilibrium is used.Middle beast
Doctor thinks that chicken infectious anemia belongs to Chinese veterinarian's " asthenia ", " Blood deficiency " category.The generation of primary disease is with the dirty relation of heart spleen kidney three the most
Closely, the kidney being the origin of congenital constitution, and main bone gives birth to marrow, if congenital defect, deficiency of the kidney, then marrow do not fill, essence and blood sharing the same origin, damage of essence then blood
Lose, have a guilty conscience then can not main blood, insufficiency of the spleen, blood of can not uniting, therefore blood deficiency occurs, the disease such as bleeding.The spleen being the foundation of acquired constitution, diet need through
The transporting of spleen could generate QI and blood, if drink is intended to overstrain internal injury, temper can be made impaired, QI and blood biochemical function goes down, and produces QI and blood not
Foot shows.Chicken infectious anemia is mainly asthenia of qi and blood and loses, deficiency of both the heart and spleen, deficiency of kidney-essence, therefore controls suitable vigorate qi and replenish the blood, invigorating the heart and spleen,
Kidney tonifying, essence replenishing.
Medicine of the present invention be reuse Radix Astragali air making-up and spleen enlivening, spleen invigorating training in as a means of hemopoietic source, the prosperous then blood of gas give birth to, gas be blood it
General, gas row then live by blood；Chinese angelica blood supplementing promoting blood circulation, blood-nourishing and battalion, the nutrient blood of complement void, two medicine phases 5 qi-supplementing, blood-engendering, Yin grows while yang is generating is common
For monarch drug.Herba Cynomorii invigorating the liver and kidney, invigorating kidney-YANG, bone and muscle strengthening；Radix Achyranthis Bidentatae eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, conducting blood to flow downwards；Herba Cistanches: mend
Kidney yang, benefiting essence-blood；Fructus Psoraleae reinforcing the kidney and supporting YANG, improving inspiration by invigorating kidney-QI warming the spleen；Four medicine kidney-tonifying sperm-generatings, essence and blood sharing the same origin, the full then blood of essence is full of.Radix Codonopsis invigorating middle warmer
QI invigorating, strengthening spleen and tonifying lung；Poria spleen invigorating mind calming, promoting diuresis to eliminate damp pathogen；Chinese yam spleen-strengtheningporridge tonifying the lung, beneficial stomach kidney tonifying, reinforce the kidney beneficial essence, Chinese yam spleen-strengtheningporridge is mended
Kidney, strengthens spleen and stomach function, the spleen being the foundation of acquired constitution, diet the transporting through spleen need to could generate QI and blood, and temper is healthy and vigorous, QI and blood biochemistry work(
Can strengthen；Fructus Jujubae air making-up and spleen enlivening, blood-nourishing reinforcing the heart.Above eight taste kidney and spleen invigorating nourishing hearts are ministerial drug altogether.Caulis Spatholobi blood circulation promoting and enriching, relaxing muscles and tendons
Active for adjuvant drug.Radix Glycyrrhizae invigorating the spleen and replenishing QI, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription are to make medicine.
The present invention has vigorate qi and replenish the blood, kidney tonifying, essence replenishing, invigorating the heart and spleen, strengthening vital QI to eliminate pathogenic factors function.Prescription is fully with reference to Chinese veterinarian
The eight guiding principles for diagnosis, defensive-qi-nutrient-blood, determining the pathogenesis of ZANG-FU disease based on the differentiation of symptoms and signs are theoretical, and, with controlling, with YAOJING specially, compatibility is careful and precise, embodies medication and such as uses military forces, uses military forces it for QI and blood
Road is essence, and the road of medication is pure prescription characteristic.
Modern veterinary's pharmacological research and clinical prolonged application, it was verified that Chinese medicine has overall curative effect height, are not likely to produce
Drug resistance, residual is low, and the advantages of toxic and side effects are little, it has significant suppression to the growth of many virus causing diseases with breeding and makees
With even up to killing the pharmacological effect of cause of disease.The present invention is according to the cause of disease of chicken infectious anemia, pathogenesis, clinical pathology
And drug mechanism, carry out Chinese medicine compound preventing and treating chicken infectious anemia, develop evident in efficacy, reliable in quality, application
Convenient, cheap compound Chinese medicinal preparation, and popularization and application in poultry produces, for the sound development tool promoting poultry husbandry
There are highly important economy and social meaning.The results showed, the Chinese medicine composition of the present invention has vigorate qi and replenish the blood, the tonification heart
Spleen, kidney tonifying, essence replenishing, strengthening vital QI to eliminate pathogenic factors function, can effectively prevent and treat chicken infectious anemia.
Specific embodiment
Below example facilitates a better understanding of the present invention, but does not limit the present invention.Experiment in following embodiments
Method, if no special instructions, is conventional method.Test material used in following embodiments, if no special instructions, is city
Sell.
The formula of the Chinese medicine composition for preventing and treating chicken infectious anemia of the present invention is as follows:
The Radix Astragali 300 ± 10 weight portion, Radix Angelicae Sinensis 100 ± 10 weight portion, Herba Cynomorii 100 ± 10 weight portion, Radix Achyranthis Bidentatae 100 ± 10 weight portion,
Herba Cistanches 50 ± 5 weight portion, Fructus Psoraleae 100 ± 10 weight portion, Radix Codonopsis 100 ± 10 weight portion, Poria 50 ± 5 weight portion, Rhizoma Dioscoreae
100 ± 10 weight portions, Fructus Jujubae 80 ± 10 weight portion, Caulis Spatholobi 80 ± 10 weight portion, Radix Glycyrrhizae Preparata 50 ± 5 weight portion.
The preparation method of the Chinese medicine composition for preventing and treating chicken infectious anemia of the present invention is:
Medicine is pulverized, sieves, mixing and obtain final product.
During use, by direct for Chinese medicine composition mixed fodder feeding, dose is every plumage 1-3g, once a day, continuously takes
5-7 days.Dose within chicken focuses on 1kg is every plumage 1g, and the particle diameter sieving during preparation is 80 mesh.
Or the Chinese medicine composition boiled water of equivalent is reconstituted, waits temperature and gavage.
The Chinese medicine preparation preparing within the above range all can effectively prevent and treat chicken infectious anemia, in above-mentioned dose and
In the case of Time of Administration, more than 88.4%, the cure rate of middle dosage (every plumage 2g) exists the cure rate of high dose (every plumage 3g)
More than 85.3%, the cure rate of low dosage (every plumage 1g) is more than 72.5%.
It is below several preferred embodiments, wherein optimal with the therapeutic effect of the Chinese medicine preparation of embodiment 1 preparation.
Embodiment 1
The formula of the Chinese medicine composition for preventing and treating chicken infectious anemia of the present invention is as follows:
Radix Astragali 30kg, Radix Angelicae Sinensis 10 kg, Herba Cynomorii 10 kg, Radix Achyranthis Bidentatae 10 kg, Herba Cistanches 5 kg, Fructus Psoraleae 10 kg, Radix Codonopsis 10 kg,
Poria 5 kg, Rhizoma Dioscoreae 10 kg, Fructus Jujubae 8 kg, Caulis Spatholobi 8 kg, Radix Glycyrrhizae Preparata 5 kg.
The preparation method of the Chinese medicine composition for preventing and treating chicken infectious anemia of the present invention is:
Medicine is pulverized, sieves, mixing and obtain final product.
During use, by direct for Chinese medicine composition mixed fodder feeding, dose is every plumage 1-3g, once a day, continuously takes
5-7 days.Dose within chicken focuses on 1kg is every plumage 1g, and the particle diameter sieving during preparation is 80 mesh.
Embodiment 2
The formula of the Chinese medicine composition for preventing and treating chicken infectious anemia of the present invention is as follows:
Radix Astragali 290g, Radix Angelicae Sinensis 90g, Herba Cynomorii 90g, Radix Achyranthis Bidentatae 110g, Herba Cistanches 55g, Fructus Psoraleae 110g, Radix Codonopsis 110g, Poria 45g,
Rhizoma Dioscoreae 90g, Fructus Jujubae 70g, Caulis Spatholobi 70g, Radix Glycyrrhizae Preparata 45g.
The preparation method of the Chinese medicine composition for preventing and treating chicken infectious anemia of the present embodiment and using method and enforcement
Example 1 is identical.
Embodiment 3
The formula of the Chinese medicine composition for preventing and treating chicken infectious anemia of the present invention is as follows:
Radix Astragali 310g, Radix Angelicae Sinensis 110g, Herba Cynomorii 110g, Radix Achyranthis Bidentatae 90g, Herba Cistanches 45g, Fructus Psoraleae 90g, Radix Codonopsis 90g, Poria 55g, mountain
Medicine 110g, Fructus Jujubae 90g, Caulis Spatholobi 90g, Radix Glycyrrhizae Preparata 55g.
The preparation method of the Chinese medicine composition for preventing and treating chicken infectious anemia of the present embodiment and using method and enforcement
Example 1 is identical.
Embodiment 4
The formula of the Chinese medicine composition for preventing and treating chicken infectious anemia of the present invention is as follows:
Radix Astragali 305g, Radix Angelicae Sinensis 105g, Herba Cynomorii 95g, Radix Achyranthis Bidentatae 105g, Herba Cistanches 50g, Fructus Psoraleae 105g, Radix Codonopsis 95g, Poria 45g,
Rhizoma Dioscoreae 95g, Fructus Jujubae 75g, Caulis Spatholobi 75g, Radix Glycyrrhizae Preparata 55g.
The preparation method of the Chinese medicine composition for preventing and treating chicken infectious anemia of the present embodiment and using method and enforcement
Example 1 is identical.
Embodiment 5
The formula of the Chinese medicine composition for preventing and treating chicken infectious anemia of the present invention is as follows:
Radix Astragali 295g, Radix Angelicae Sinensis 95g, Herba Cynomorii 105g, Radix Achyranthis Bidentatae 95g, Herba Cistanches 55g, Fructus Psoraleae 95g, Radix Codonopsis 105g, Poria 50g, mountain
Medicine 100g, Fructus Jujubae 85g, Caulis Spatholobi 75g, Radix Glycyrrhizae Preparata 45g.
The preparation method of the Chinese medicine composition for preventing and treating chicken infectious anemia of the present embodiment and using method and enforcement
Example 1 is identical.
Embodiment 6
The formula of the Chinese medicine composition for preventing and treating chicken infectious anemia of the present invention is as follows:
Radix Astragali 300g, Radix Angelicae Sinensis 110g, Herba Cynomorii 110g, Radix Achyranthis Bidentatae 110g, Herba Cistanches 50g, Fructus Psoraleae 105g, Radix Codonopsis 105g, Poria
55g, Rhizoma Dioscoreae 105g, Fructus Jujubae 80g, Caulis Spatholobi 75g, Radix Glycyrrhizae Preparata 50g.
The preparation method of the Chinese medicine composition for preventing and treating chicken infectious anemia of the present embodiment and using method and enforcement
Example 1 is identical.
Embodiment 7
Clinical effect trial
The present invention using random double blind test method the morbidity chicken group making a definite diagnosis chicken infectious anemia carried out various dose (high, in,
Low dosage, respectively 3g/ plumage, 2g/ plumage, 1g/ plumage) Clinical Treatment Test, and be positive drug from compound vitamin+penicillin group
Thing matched group.Observe the therapeutical effect to chicken infectious anemia for the present invention, to inquire into the feasibility that it is applied in Production of Livestock and Poultry.
Diagnostic criteria
Diseased chicken shows as spiritual depressed, weakness, is slow in action, beak, wattle, skin of face and visual mucosal pallor, undergrowth,
Weight loss, the diseased chicken bodily form becomes substantially to become thin.On one's deathbed before it is also shown diarrhoea.The visible diseased chicken of cut open inspection is become thin, muscle and internal organs
Organ is pale, anemia.Liver and kidney enlargement, colour fading or faint yellow, blood is thin, cruor time extending.The most distinctive it is
Pathological changes bone marrow suppression, femoral bone marrow is in fatty color, faint yellow or pink, and the color of some case bone marrow is in kermesinus.
Atrophy of thymus gland is in dark reddish brown.
Natural occurrence is randomly divided into 5 groups through the chicken that clinical diagnosises are confirmed, every group of 30 plumages.1-3 group is treatment group, adopts
The medicine (setting basic, normal, high three groups of dosage, respectively 3g/ plumage, 2g/ plumage, 1g/ plumage respectively) of the embodiment of the present invention 1 preparation；4th
Organize as compound vitamin+Positive of penicillin skin-test drug control group；5th group is positive controls (infection, be not administered).It is individually insulated and raise
Support, the symptom of itemized record diseased chicken, healings, death situations such as.Table 1 is grouped situation for chicken infectious anemia Experiment on therapy.
Table 1
Administering mode
Dosage is calculated according to diseased chicken quantity, after test medicine and a little concentrate are mixed thoroughly, allows diseased chicken naturally to search for food medication；To not
Can naturally search for food the diseased chicken of medication, test medicine be added water and gavages administration after a little mixing.Each administration 1 before every morning feeding
Secondary, successive administration 7 days, continues after drug withdrawal to observe 3 days.After administration, tested chicken is allowed to free choice feeding, drinking-water.
1 group of medicine: the diseased chicken amount of feeding is 1g/ plumage, even feeds 7 days；2 groups of medicine: the diseased chicken amount of feeding is 2g/ plumage, even feeds 5 days；
3 groups of medicine: the diseased chicken amount of feeding is 3g/ plumage, even feeds 7 days.Positive drug control group: every plumage chicken feeds compound vitamin+green grass or young crops daily
Mycin (by specification use), even feeds 7 days；Positive controls: be not administered.
Observation index
During clinical trial, that is, before being administered, during administration and in 3d after drug withdrawal, the clinical condition of daily observed and recorded experimental chicken
The General Symptomies such as whether shape, active situation, poor appetite or enhancement, body temperature increase, spirit, if death occurs and pathology is analysed
Situations such as.
Therapeutic outcome
Experimental result: after treatment group medicine feed 24h, the spirit of medicine group diseased chicken is better than positive controls, counts dead after 36h
Number, medicine group diseased chicken is substantially fewer than positive controls death toll；Observe after 48h, different degrees of improvement, sun in medicine each group
Property matched group still have dead successively generation.After 7 days, the spirit of medicine group chicken, appetite take a favorable turn (increase from feeding capacity and find out),
Feces are normal.Table 2 is chicken infectious anemia Experiment on therapy therapeutic outcome.
Table 2
Test statistics result shows in medicine high-dose therapy group 30 ptilosis chicken of the present invention, has 27 plumages to fully recover, 3 plumage lethargy,
Feed intake is less than normally, but does not have death, and cure rate is 90.0%；In middle dosage treatment group 30 ptilosis chicken, 26 plumages are had to fully recover, 4
Plumage lethargy, feed intake is less than normally, but does not have death, and cure rate is 86.70%；In low dose therapy group 30 ptilosis chicken,
There are 22 plumage recoveries from illness, 6 plumage lethargy, feed intake is less than normally, and the feces of discharge turn white, dead 2 plumages, and cure rate is
73.3%；In compound vitamin+penicillin treatment group (matched group) 30 diseased chicken, there are 18 plumage recoveries from illness, 10 plumage lethargy, search for food
Amount is less than normally, and has 2 plumages dead, and cure rate is 60.0%；In positive controls (not being administered) 30 ptilosis chicken, there are 24 plumages still smart
God is dispirited, and feed intake is less than normally, and has 6 plumages dead.
High, middle dosage treatment group mortality rate is 0.00%, and treatment group, compared with matched group diseased chicken, shows as symptom mitigation, the course of disease
Shorten, experiment proves that the high, medium and low dosage of the present invention has therapeutical effect, energy relief of symptoms to chicken infectious anemia, reduces dead
Die rate, and high, middle dosage is reducing mortality rate, improves the aspects such as cure rate and is superior to compound vitamin+penicillin treatment group
Effect.Effect high, that the middle dosage present invention can reach survival rate of curing the disease, improve, and both zero differences in 0.05 level,
Therefore middle dosage during Clinical practice, can be adopted, so not only economic curative effect but also notable.
From the point of view of result of the test, the Chinese medicine composition of the present invention has vigorate qi and replenish the blood, invigorating the heart and spleen, kidney tonifying, essence replenishing, righting
The function of eliminating evil.Do not find that this medicine has untoward reaction during clinical trial.High, medium and low dosage has to chicken infectious anemia
Preferably therapeutic effect, high, middle dosage is better than compound vitamin+penicillin therapeutic effect to therapeutic effect.The controlling of low dose group
Therapeutic effect is less than high, middle dose group, middle and high dosage group there are no significant in terms of mortality rate, cure rate and total effective rate difference.
Should be according to the weight of the state of an illness and treatment cost it is proposed that clinical practice be with middle dosage (chicken, 2g, (chicken halves) 1 time/d, spice clothes
With) preferably, it is used in conjunction 5-7 days.
Finally it is noted that the foregoing is only the preferred embodiments of the present invention, it is not limited to the present invention,
Although being described in detail to the present invention with reference to the foregoing embodiments, for a person skilled in the art, it still may be used
To modify to the technical scheme described in foregoing embodiments, or equivalent is carried out to wherein some technical characteristics.
All any modification, equivalent substitution and improvement within the spirit and principles in the present invention, made etc., should be included in the present invention's
Within protection domain.
Claims (7)
1. a kind of Chinese medicine composition for preventing and treating chicken infectious anemia it is characterised in that: described Chinese medicine composition is by following heavy
Each crude drug composition of amount part: the Radix Astragali 300 ± 10 weight portion, Radix Angelicae Sinensis 100 ± 10 weight portion, Herba Cynomorii 100 ± 10 weight portion, Radix Achyranthis Bidentatae
100 ± 10 weight portions, Herba Cistanches 50 ± 5 weight portion, Fructus Psoraleae 100 ± 10 weight portion, Radix Codonopsis 100 ± 10 weight portion, Poria 50
± 5 weight portions, Rhizoma Dioscoreae 100 ± 10 weight portion, Fructus Jujubae 80 ± 10 weight portion, Caulis Spatholobi 80 ± 10 weight portion, Radix Glycyrrhizae Preparata 50 ± 5 weight
Amount part.
2. Chinese medicine composition according to claim 1 it is characterised in that: described Chinese medicine composition is each by following weight portion
Crude drug forms: the Radix Astragali 300 weight portion, Radix Angelicae Sinensis 100 weight portion, Herba Cynomorii 100 weight portion, Radix Achyranthis Bidentatae 100 weight portion, Herba Cistanches 50 weight
Amount part, Fructus Psoraleae 100 weight portion, Radix Codonopsis 100 weight portion, Poria 50 weight portion, Rhizoma Dioscoreae 100 weight portion, Fructus Jujubae 80 weight portion, chicken
Caulis seu Radix Schisandrae Henryi 80 weight portion, Radix Glycyrrhizae Preparata 50 weight portion.
3. the Chinese medicine composition described in claim 1 or 2 preparation method it is characterised in that: each component of formula ratio is pulverized,
Mix after sieving and obtain final product.
4. application in the medicine of preparation treatment preventing and treating chicken infectious anemia for the Chinese medicine composition described in claim 1 or 2.
5. a kind of medicine it is characterised in that: its effective ingredient be claim 1 or 2 described in Chinese medicine composition.
6. medicine according to claim 5 it is characterised in that: the dosage form of described medicine be powder.
7. medicine according to claim 5 it is characterised in that: the dose of every chicken be 1-3g, once a day, focus on
The dose of the chicken within 1kg is every chicken 1g.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101401891A (en) * | 2008-11-10 | 2009-04-08 | 郑磊 | Traditional Chinese medicine decoction for treating aplastic anemia |
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Application publication date: 20170201 |