CN106822536B - A kind of Chinese medicine composition and the preparation method and application thereof for treating toxplasmosis in pigs - Google Patents
A kind of Chinese medicine composition and the preparation method and application thereof for treating toxplasmosis in pigs Download PDFInfo
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Abstract
The present invention is a kind of Chinese medicine composition for treating toxplasmosis in pigs, which includes the raw material of following weight proportion：Inonotus obliquus 15 30；Bi Collettii 15 30；Chinese torreyanut 10 20.The present invention also provides the preparation methods of above-mentioned Chinese medicine composition.The present invention also provides above-mentioned Chinese medicine compositions to prepare the application in treating toxplasmosis in pigs.Chinese medicine composition of the present invention, which uses, has effects that clearing heat and detoxicating, desinsection, spleen benefiting and stimulating the appetite, promoting digestion and removing indigestion, the Chinese prescription for adjusting immunity of organisms, and compatibility is reasonable, at low cost, can achieve the effect that treating both manifestation and root cause of disease.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition for treating toxplasmosis in pigs further relates to
The preparation method and applications of the Chinese medicine composition.
Background technology
Toxplasmosis in pigs is also known as toxoplasmosis, is a kind of protozoosis caused by Toxoplasma goodii, by mouth, eye, nose,
The approach such as respiratory tract, enteron aisle and skin invade pig body, and characterized by high fever, breathing and nervous symptoms and breeding difficulty, pig breaks out
The pig on entire pig farm can be made to fall ill when toxoplasmosis, the death rate is up to 60% or more.Wherein, piglet morbidity is particularly acute, more
In acute process, sick pig gives up eat suddenly, and body temperature is increased to 41 DEG C or more, is short of breath, and is in abdomen formula or the clear nose of dog sitting posture respiratory flow
There is serosity or purulent secretion in tears intraocular.Often there is constipation, in pelletized form excrement, outer attached mucus, some affected pigs are after the onset
Phase has loose bowels urine in crocus, and minority is vomitted.Affected pig spirit is depressed, significantly weak.There is conjunctival congestion in a few days after the onset, has
Gum, some four limbs and whole-body muscle are stiff, on foot unstable or even dysstasia, chronic sick pig depauperation, diarrhea, with
Blindness and nervous symptoms.With the development of the state of an illness, on the inside of earflap, nose, lower limb, stock, lower abdomen etc. occur purplish-red macula or
Between have a dot bleeding, some sick pigs form silly skin on auricular concha, and dry necrosis occurs for have sharp ears, finally because breathing extremely difficult and body
Temperature drastically declines and dead, and pregnant pig often occurs to miscarry or stillborn foetus.
Currently, toxplasmosis in pigs generally is prevented and treated using sulfa drugs, and sulfa drugs easy tos produce
Medicament residue causes prodigious threat to pig breeding industry.
Invention content
The technical problem to be solved by the present invention is in view of the deficiencies of the prior art, provide a kind of formula advantages of simple, treat
The Chinese medicine composition for the treatment toxplasmosis in pigs imitated.
There is provided the Chinese medicines for the treatment of toxplasmosis in pigs as described above for another technical problem to be solved by this invention
The preparation method of compositions.
The present invention also provides above-mentioned Chinese medicine compositions to prepare the application in treating toxplasmosis in pigs.
The technical problem to be solved by the present invention is to what is realized by technical solution below.The present invention is a kind for the treatment of
The Chinese medicine composition of toxplasmosis in pigs, its main feature is that, which includes the raw material of following weight proportion：Inonotus obliquus
15-30；Bi Collettii 15-30；Chinese torreyanut 10-20.
In the Chinese medicine composition technical solution of above-described treatment toxplasmosis in pigs, the weight proportion of each raw material is：Birch
Brown pore fungi 20；Bi Collettii 20；Chinese torreyanut 10.
In the Chinese medicine composition technical solution of above-described treatment toxplasmosis in pigs：The Chinese medicine composition further includes following
The raw material of weight proportion：Pumpkin seeds 5-10；Radix bupleuri 8-12；Radix Glycyrrhizae 10-15.It is further preferred that the weight of the pumpkin seeds
Proportioning is 8；The weight proportion of the radix bupleuri is 9；The weight proportion of the Radix Glycyrrhizae is 10.
In the Chinese medicine composition technical solution of above-described treatment toxplasmosis in pigs：The Chinese medicine composition further includes following
The raw material of weight proportion：Butterflybush flower 2-6.It is further preferred that the weight proportion of the butterflybush flower is 3.
In the Chinese medicine composition technical solution of above-described treatment toxplasmosis in pigs：The Chinese medicine composition further includes following
The raw material of weight proportion：Chinese violet 4-9；Honeysuckle 6-10；Eucalyptus robusta 8-12；Malt 5-10；Dried orange peel 2-5.Further preferably
The weight proportion on ground, the Chinese violet is 6.5；The weight proportion of the honeysuckle is 8.5；The weight of the eucalyptus robusta
Amount proportioning is 12；The weight proportion of the malt is 10；The weight proportion of the dried orange peel is 3.
The present invention also provides the preparation methods of the Chinese medicine composition described in above technical scheme, its main feature is that, step
It is as follows：
（1）Each raw material is weighed by the weight proportion, crushes or shreds, mixing obtains mixed raw material medicine；
（2）Mixed raw material medicine 8-10 times of water measured of total weight is added into mixed raw material medicine, impregnates 4-6h, intense fire is boiled to boiling
It rises, 20-30min is maintained after boiling, then with 0.5-1h is cooked by slow fire, filter, obtain decocting liquid and filter residue, filter residue uses 3-6 weight again
Water again decocts 2-3 times, each 2-3h, and filtering discards filter residue, merges each secondary decocting liquid, is concentrated under reduced pressure, obtains at 60-65 DEG C
Relative density is the medicinal extract of 1.1-1.2；
（3）To step（2）80-90% ethyl alcohol is added in obtained medicinal extract, until determining alcohol reaches 60-75%, is sufficiently stirred
It is even, it staticly settles, filters, filtrate decompression concentration removes ethyl alcohol, obtains the concentrate that the relative density at 60-65 DEG C is 1.25-1.3；
（4）By step（3）Powder, granule, oral solution or injection is made in obtained concentrate.
Chinese medicine composition of the present invention is applied in the drug for preparing treatment toxplasmosis in pigs.
The pharmacological property of Chinese medicine material of the present invention is as follows：
Inonotus obliquus（Inonotus obliquus）：Also it is inonotus obliquus, it is civil as the medicinal for the treatment of disease in Russia
Fungi belongs to pure Chinese medicine, and long-term zoopery and clinical trial show to use Inonotus obliquus without any side effects, but also
With good anticancer, hypoglycemic, Immunestimulatory effect, can enhance human immunity, additionally it is possible to effectively inhibit infective virus,
There is apparent therapeutic effect to hepatitis, gastritis, duodenal ulcer, ephritis, and vomiting, diarrhea, gastrointestinal dysfunction are controlled
Treatment acts on, in addition, research confirms that Fuscoporia obliqua polysaccharide has preferable resisting toxoplasmosis activity.
Bi Collettii：The effect of sweet and neutral is included into liver, kidney, stomach, there is dampness removing to go turbid, wind expelling stagnation removing, cures mainly stranguria with turbid discharge leukorrhea, waist
Knee numbness pain, damp and hot sore, wind-dispelling, dampness removing control rheumatoid arthritis stubborn, lumbocrural pain, difficult urination, stranguria with turbid discharge, seminal emission, damp and hot sore.Bi
Dioscin or dioscorea sapotoxin contained in Collettii rhizome have insecticidal action, Dioscin, carat plug woods glucoside also antimycotic
Effect.Studies have shown that Bi Collettii decocting liquid has the effect of resisting toxoplasmosis.
Chinese torreyanut：There is killing insect and eliminating accumulation to cure mainly hook the effect of moistening the lung and relieve the cough, relax bowel for sweet and neutral, return lung, stomach, large intestine channel
Parasitosis, roundworm disease, abdominal pain due to enterositosis, infantile malnutrition, soap cough, the cards such as constipation, pharmacological research its to hookworm, tapeworm, pinworm
Worm has inhibition killing effect, a variety of fat that enteron aisle lubricating oil to be discharged conducive to polypide.
Pumpkin seeds：Sweet and neutral returns large intestine channel, has insect-expelling function, cures mainly lower breast, inducing diuresis for removing edema, main tapeworm, roundworm, blood suction
Worm, hookworm, enterobiasis, hemorrhoid.
Radix bupleuri：Hardship is slightly cold, Return liver, gallbladder channel, has antipyretic, calm, analgesia, anti-inflammatory, the effect of preventing and curing malaria disease.
Radix Glycyrrhizae：It is flat, sweet, return 12 warps.With removing toxic substances, eliminating the phlegm, analgesic, spasmolysis so that the pharmacological actions such as anticancer.In Chinese medicine
On, Radix Glycyrrhizae is invigorated the spleen and benefited qi, and cough moistening lung, emergency removing toxic substances, hundred medicines of reconciliation are grown.
Butterflybush flower：It is sweet, it is slightly cold, return liver warp has the function of heat-clearing nourishing the liver, improving eyesight and anti-inflammatory, can improve the screen film that looks unfamiliar, liver
Empty mesh is dark, blurring of vision.
Chinese violet：Bitter, acrid, cold, converge to heart and liver channels, containing the ingredients such as glucoside, flavonoids, wax, cerinic acid and unsaturated acids, tool
There is the effect of clearing heat and detoxicating, cool blood detumescence.
Honeysuckle：It is sweet, it trembles with fear, return lung, the heart, stomach have clearing heat and detoxicating, wind-heat dissipating effect, are used for carbuncle swells furunculosis, larynx
Numbness, erysipelas, toxic-heat and blood stasis, anemopyretic cold, warm disease heating.Honeysuckle antibacterial range is wide, blue to a variety of gram-positive bacterias and leather
Family name's negative bacterium has inhibiting effect, and has antiendotoxin, enhancing immune function, anti-inflammatory, refrigeration function.
Eucalyptus robusta：Micro-pungent, slight bitter put down, cure mainly that dispelling wind is antipyretic, and inhibiting bacteria and diminishing inflammation, anti-corrosion is antipruritic, can be used for preventing popular sexuality
It emits, controls enteritis, dysentery, filariasis can adjust body's immunity.
Malt：Sweet and neutral, returns spleen, stomach cure mainly promoting the circulation of qi helps digestion, spleen benefiting and stimulating the appetite, and moves back newborn dissipate-swelling is used for dyspepsia, gastral cavity abdomen
Distending pain, spleen eating less.
Dried orange peel：Bitter, acrid in flavour and warm in nature, return lung, the spleen channel have the function of regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm, cure mainly poor appetite, abdomen
Bitterly, tripe swollen, diarrhea, productive cough due to phlegm-damp etc..
Compared with prior art, Chinese medicine composition of the present invention is used with clearing heat and detoxicating, desinsection, spleen benefiting and stimulating the appetite, digestion-promoting
Product, the Chinese prescription for adjusting immunity of organisms effect, compatibility is reasonable, at low cost, can achieve the effect that treating both manifestation and root cause of disease.It uses
When, it can admix in pannage or be added in pig drinking water or directly be injected, sick pig is treated, treat pig arch
The effect of parasitosis is good, no obvious toxic-side effects, small to the irritation of body, and avoids and caused in pig body using antibiotic
Medicament residue.Meanwhile the preparation method of Chinese medicine composition of the present invention is easy to operate, and product quality stabilization is prepared, is suitble to
Industrialized production.
Specific implementation mode
The specific technical solution of the present invention described further below, in order to which those skilled in the art is further understood that
The present invention, without constituting the limitation to its right.
Embodiment 1, a kind of Chinese medicine composition for treating toxplasmosis in pigs, it is by the Chinese medicine material system of following weight proportion
At：Inonotus obliquus 15；Bi Collettii 15；Chinese torreyanut 10.
Preparation method：
（1）Each raw material is weighed by the weight proportion, crushes or shreds, mixing obtains mixed raw material medicine；
（2）The water of 10 times of amounts of mixed raw material medicine total weight is added into mixed raw material medicine, impregnates 6h, intense fire is boiled to boiling,
30min is maintained after boiling, then with 1h is cooked by slow fire, is filtered, decocting liquid and filter residue are obtained, and filter residue decocts 3 with the water of 6 times of weight again
Secondary, each 3h, filtering discards filter residue, merges each secondary decocting liquid, is concentrated under reduced pressure, and obtains the leaching that relative density is 1.2 at 65 DEG C
Cream；
（3）To step（2）90% ethyl alcohol is added in obtained medicinal extract, until determining alcohol reaches 75%, stirs, stands
Precipitation, filtering, filtrate decompression concentration remove ethyl alcohol, obtain the concentrate that relative density is 1.3 at 65 DEG C；
（4）To step（3）Water for injection is added in obtained concentrate, is diluted to every 1mL crude drug amounts containing 2g, is filtered, is filled
Dress sterilizes to get injection.
Application method：Intramuscular injection, every time by 1kg pig weight injection 0.1-0.2mL this injection, 1-2 times on the one.
Embodiment 2, a kind of Chinese medicine composition for treating toxplasmosis in pigs, it is by the Chinese medicine material system of following weight proportion
At：Inonotus obliquus 30；Bi Collettii 30；Chinese torreyanut 20.
Preparation method and application method are the same as embodiment 1.
Embodiment 3, a kind of Chinese medicine composition for treating toxplasmosis in pigs, it is by the Chinese medicine material system of following weight proportion
At：Inonotus obliquus 20；Bi Collettii 20；Chinese torreyanut 10.
Preparation method and application method are the same as embodiment 1.
Embodiment 4, in the Chinese medicine composition of the treatment toxplasmosis in pigs described in embodiment 1-3 any one, the Chinese medicine group
Close the raw material that object further includes following weight proportion：Pumpkin seeds 5；Radix bupleuri 8；Radix Glycyrrhizae 10.
Preparation method：
（1）Each raw material is weighed by the weight proportion, crushes or shreds, mixing obtains mixed raw material medicine；
（2）The water of 9 times of amounts of mixed raw material medicine total weight is added into mixed raw material medicine, impregnates 6h, intense fire is boiled to boiling, boiling
30min is maintained after rising, then with 0.5h is cooked by slow fire, is filtered, decocting liquid and filter residue are obtained, and filter residue decocts 2 with the water of 5 times of weight again
Secondary, each 3h, filtering discards filter residue, merges each secondary decocting liquid, is concentrated under reduced pressure, and obtains the leaching that relative density is 1.15 at 65 DEG C
Cream；
（3）To step（2）90% ethyl alcohol is added in obtained medicinal extract, until determining alcohol reaches 65%, stirs, stands
Precipitation, filtering, filtrate decompression concentration remove ethyl alcohol, obtain the concentrate that relative density is 1.28 at 65 DEG C；
（4）To step（3）It after obtained concentrate spray drying treatment, crushes, appropriate amount of starch and dextrin is added, mixing is equal
It is even, it is granulated to get granule.
Application method：Mixed feeding admixes feed by the 0.15-0.2% of pig weight, or this granule 1.5g is added per 1L water, leads to
It is oral to cross drinking-water.
Embodiment 5, in the Chinese medicine composition of the treatment toxplasmosis in pigs described in embodiment 1-3 any one, the Chinese medicine group
Close the raw material that object further includes following weight proportion：Pumpkin seeds 10；Radix bupleuri 12；Radix Glycyrrhizae 15.
Preparation method and application method are the same as embodiment 4.
Embodiment 6, in the Chinese medicine composition of the treatment toxplasmosis in pigs described in embodiment 1-3 any one, the Chinese medicine group
Close the raw material that object further includes following weight proportion：Pumpkin seeds 8；Radix bupleuri 9；Radix Glycyrrhizae 10.
Preparation method and application method are the same as embodiment 4.
Embodiment 7, in the Chinese medicine composition of the treatment toxplasmosis in pigs described in embodiment 4-6 any one, the Chinese medicine group
Close the raw material that object further includes following weight proportion：Butterflybush flower 2.
Preparation method：
（1）Each raw material is weighed by above-mentioned weight proportion, crushes or shreds, mixing obtains mixed raw material medicine；
（2）The water of 8 times of amounts of mixed raw material medicine total weight is added into mixed raw material medicine, impregnates 4h, intense fire is boiled to boiling, boiling
20min is maintained after rising, then with 0.5h is cooked by slow fire, is filtered, decocting liquid and filter residue are obtained, and filter residue decocts 2 with the water of 3 times of weight again
Secondary, each 2h, filtering discards filter residue, merges each secondary decocting liquid, is concentrated under reduced pressure, and obtains the leaching that relative density is 1.1 at 60 DEG C
Cream；
（3）To step（2）80% ethyl alcohol is added in obtained medicinal extract, until determining alcohol reaches 60%, stirs, stands
Precipitation, filtering, filtrate decompression concentration remove ethyl alcohol, obtain the concentrate that relative density is 1.25 at 60 DEG C；
（4）To step（3）Pure water is added in obtained concentrate, is diluted to every 1mL crude drug amounts containing 1g, filters, it is filling, it goes out
Bacterium is to get oral solution.
Application method：This oral solution 1.5-2mL is added per 1L water in mixed drink, oral by drinking water.
Embodiment 8, in the Chinese medicine composition of the treatment toxplasmosis in pigs described in embodiment 4-6 any one, the Chinese medicine group
Close the raw material that object further includes following weight proportion：Butterflybush flower 6.
Preparation method and application method are the same as embodiment 7.
Embodiment 9, in the Chinese medicine composition of the treatment toxplasmosis in pigs described in embodiment 4-6 any one, the Chinese medicine group
Close the raw material that object further includes following weight proportion：Butterflybush flower 3.
Preparation method and application method are the same as embodiment 7.
Embodiment 10, in the Chinese medicine composition of the treatment toxplasmosis in pigs described in embodiment 7-9 any one, the Chinese medicine group
Close the raw material that object further includes following weight proportion：Chinese violet 4；Honeysuckle 6；Eucalyptus robusta 8；Malt 5；Dried orange peel 2.
Preparation method：
（1）Each raw material is weighed by the weight proportion, crushes or shreds, mixing obtains mixed raw material medicine；
（2）The water of 10 times of amounts of mixed raw material medicine total weight is added into mixed raw material medicine, impregnates 5h, intense fire is boiled to boiling,
25min is maintained after boiling, then with 0.8h is cooked by slow fire, is filtered, decocting liquid and filter residue are obtained, and filter residue decocts 2 with the water of 4 times of weight again
Secondary, each 2.5h, filtering discards filter residue, merges each secondary decocting liquid, is concentrated under reduced pressure, and obtains the leaching that relative density is 1.2 at 60 DEG C
Cream；
（3）To step（2）85% ethyl alcohol is added in obtained medicinal extract, until determining alcohol reaches 70%, stirs, stands
Precipitation, filtering, filtrate decompression concentration remove ethyl alcohol, obtain the concentrate that relative density is 1.25 at 60 DEG C；
（4）To step（3）It after obtained concentrate spray drying treatment, crushes, appropriate amount of starch and dextrin is added, mixing is equal
It is even, 50 mesh sieve is crossed to get powder；
Application method：Mixed feeding admixes feed by the 0.15-0.2% of pig weight.
Embodiment 11, in the Chinese medicine composition of the treatment toxplasmosis in pigs described in embodiment 7-9 any one, the Chinese medicine group
Close the raw material that object further includes following weight proportion：Chinese violet 9；Honeysuckle 10；Eucalyptus robusta 12；Malt 10；Dried orange peel 5.
Preparation method and application method are the same as embodiment 10.
Embodiment 12, in the Chinese medicine composition of the treatment toxplasmosis in pigs described in embodiment 7-9 any one, the Chinese medicine group
Close the raw material that object further includes following weight proportion：Chinese violet 6.5；Honeysuckle 8.5；Eucalyptus robusta 12；Malt 10；Dried orange peel 3.
Preparation method：
（1）Each raw material is weighed by the weight proportion, crushes or shreds, mixing obtains mixed raw material medicine；
（2）The water of 8 times of amounts of mixed raw material medicine total weight is added into mixed raw material medicine, impregnates 5.5h, intense fire is boiled to boiling,
25min is maintained after boiling, then with 1h is cooked by slow fire, is filtered, decocting liquid and filter residue are obtained, and filter residue decocts 2 with the water of 3 times of weight again
Secondary, each 2.5h, filtering discards filter residue, merges each secondary decocting liquid, is concentrated under reduced pressure, and obtains the leaching that relative density is 1.2 at 60 DEG C
Cream；
（3）To step（2）85% ethyl alcohol is added in obtained medicinal extract, until determining alcohol reaches 75%, stirs, stands
Precipitation, filtering, filtrate decompression concentration remove ethyl alcohol, obtain the concentrate that relative density is 1.3 at 60 DEG C；
（4）To step（3）Water for injection is added in obtained concentrate, is diluted to every 1mL crude drug amounts containing 1.5g, is filtered,
It is filling, it sterilizes to get injection.
Application method：Intramuscular injection, every time by 1kg pig weight injection 0.2-0.3mL this injection, 1-2 times on the one.
Embodiment 13, experimental example.
One, animal inoculation pvaccination is tested
1, experimental animal：35 40 age in days health Huaihe River pigs, weight are purchased from Lianyungang Donghai County kind pig farm in 25-27kg,
Experimental animal is detected through clinical examination, brief introduction hemagglutination test, and toxoplasma antibody testing result is feminine gender.
2, trial drug：
Chinese herbs group：The Chinese medicine composition being prepared using the embodiment of the present invention 3；
Western medicine group：Using Sulfamonomethoxime Sodium injection, Jiangsu Nannong Hi-Tech Animal Medicine Co., Ltd.'s life
Production.
3, Toxoplasma gondii kind：It is provided by academy of agricultural sciences of Jiangsu Province veterinary institute.
4, test method：
（1）Packet design：Test pig is randomly divided into 3 groups（Chinese herbs group, western medicine group and infection control group）, in
Medicine treatment group and western medicine group every group 15 infect control group 5.
（2）Artificial infection：Chinese herbs group, western medicine group and the every toxoplasma gondii infection taste of test pig for infecting control group
Support body 2.5 × 104-3×104It is a.Since 4h after infection, body temperature 2 times is measured daily, morning body temperature is at 40 DEG C or more, afternoon
Body temperature is considered as body temperature raising at 40.5 DEG C or more, and it is same day each group body temperature to take each group experiment temperature of pig body average value, is counted with this
Pig heat type observes pig clinical symptoms daily.12h taps the abdomen microscopy after infection, amount containing worm is counted, before treatment
Index.
（3）Therapeutic test：Infect 48h according to dosage intramuscular injection trial drugs, successive administration 5 days, 0,1,3,5 after treatment
It extracts pig ascites 1 time, after the dyeing of Ji's nurse Sa decoration method, with white blood cell count(WBC) legally constituted authority meter ascites quantity containing trophozoite（A/
mL）.Wherein, Chinese herbs group Chinese medicine composition intramuscular injection of the present invention, per kilogram of body weight 0.2mL, an intramuscular injection, daily 1
It is secondary；Western medicine group is injected with Sulfamonomethoxime Sodium injection head, is used to specifications；Control group is infected, is not had to
Medicine.Test pig takes group feeding, free water.
4, test result：
To infecting the pig of toxplasmosis in pigs, Chinese medicine composition and Sulfamonomethoxime Sodium injection of the present invention is given respectively
Liquid is treated.Compared with the control group, by observing the clinical symptoms of sick pig, it is found that the sick pig clinical symptoms of Chinese herbs group are fast
Speed, which mitigates, simultaneously gradually fully recovers, and this group of pig restores normal diet after 3 days in medication.It the results are shown in Table 1.
Two, clinical test
1, experimental animal：Certain pig farm of toxplasmosis in pigs occurs for Lianyungang Donghai County, and illness rate is up to 60% or more, master
Clinical manifestation is wanted to be increased for body temperature, cough and asthma is hard and dry, poor appetite or useless exhausted.Randomly select the illness pig made a definite diagnosis
55, as test pig.
2, packet design：
Test pig is randomly divided into 6 groups, including the treatment of Chinese herbs group 1, Chinese herbs group 2, Chinese herbs group 3, Chinese medicine
Group 4, western medicine group and blank control group, wherein Chinese herbs group 1, Chinese herbs group 2, Chinese herbs group 3, Chinese medicine treatment
Group 4, western medicine group every group 10, blank control group 5.
3, therapeutic test：
Chinese herbs group 1：1kg is pressed in the Chinese medicine composition being prepared using the embodiment of the present invention 3, intramuscular injection every time
Pig weight injects 0.2mL, an intramuscular injection, 1 times a day, until healing；
Chinese herbs group 2：The Chinese medicine composition being prepared using the embodiment of the present invention 6 is admixed by the 0.2% of pig weight
Feed, until healing；
Chinese herbs group 3：The Chinese medicine composition being prepared using the embodiment of the present invention 9 is added 2mL per 1L water, passed through
Drinking-water is oral, until healing；
Chinese herbs group 4：1kg is pressed in the Chinese medicine composition being prepared using the embodiment of the present invention 12, intramuscular injection every time
Pig weight injects 0.2mL, an intramuscular injection, 1 times a day, until healing；
Western medicine group：With Sulfamonomethoxime Sodium injection intramuscular injection, use to specifications, until healing；
Blank control group：Not medication.
Test pig feeds amount so that slightly clout is degree, free water in feed trough after having enough every time.
4, experimental result：
（1）Dead pig quantity, calculates the death rate during statistics treatment；
（2）Restore normally, body temperature no longer occur and increase, cough, skin according to body temperature, spirit, appetite after sick pig medication
The clinical symptoms such as blue calculate cure rate.Treatment results are shown in Table 1.
The test result of 1. traditional Chinese medicine composition for treating toxplasmosis in pigs of the present invention of table
By experimental result it is found that Chinese medicine composition of the present invention has preferable therapeutic effect, Er Qieyu to toxplasmosis in pigs
The Western medicine for being traditionally used for treatment toxplasmosis in pigs is compared, and mean treatment number of days is shorter.
Three, model case
300 bull pork pigs are educated on Lianyungang Donghai County pig farm, and at the beginning of 2 months 2017, swinery sudden onset has 20 pigs
Spiritual depressed, poor appetite, astasia, body temperature are toxplasmosis in pigs through Disease Diagnosis of Veterinary at 40-41 DEG C.Using of the invention real
The injection for applying example 12 treats sick pig, injects 0.3mL by 1kg pig weight within the 1st day, 1 times a day, after medication, sick pig body
Temperature restores normal, slightly feeds；2nd day by 1kg pig weight inject 0.2mL, 1 times a day, after medication, sick pig can normal stand, eye
Middle secretion significantly reduces, and mental restoration is normal, and actively searches for food；0.2mL is injected by 1kg pig weight within 3rd day, 1 times a day, use
After medicine, sick pig is all fully recovered.
Claims (5)
1. a kind of Chinese medicine composition for treating toxplasmosis in pigs, which is characterized in that the Chinese medicine composition includes following weight proportion
Raw material：
Inonotus obliquus 20；Bi Collettii 20；Chinese torreyanut 10；
Pumpkin seeds 8；Radix bupleuri 9；Radix Glycyrrhizae 10；
Butterflybush flower 3.
2. Chinese medicine composition according to claim 1, which is characterized in that the Chinese medicine composition further includes following weight proportion
Raw material：Chinese violet 4-9；Honeysuckle 6-10；Eucalyptus robusta 8-12；Malt 5-10；Dried orange peel 2-5.
3. Chinese medicine composition according to claim 2, which is characterized in that the weight proportion of the Chinese violet is 6.5；
The weight proportion of the honeysuckle is 8.5；The weight proportion of the eucalyptus robusta is 12；The weight proportion of the malt is
10；The weight proportion of the dried orange peel is 3.
4. a kind of preparation method of Chinese medicine composition as described in claim 1-3 any one, which is characterized in that its step is such as
Under：
（1）Each raw material is weighed by the weight proportion, crushes or shreds, mixing obtains mixed raw material medicine；
（2）Mixed raw material medicine 8-10 times of water measured of total weight is added into mixed raw material medicine, impregnates 4-6h, intense fire is boiled to boiling,
20-30min is maintained after boiling, then with 0.5-1h is cooked by slow fire, is filtered, decocting liquid and filter residue are obtained, and filter residue uses 3-6 times of weight again
Water decocts 2-3 times, each 2-3h, and filtering discards filter residue, merges each secondary decocting liquid, is concentrated under reduced pressure, obtains opposite at 60-65 DEG C
Density is the medicinal extract of 1.1-1.2；
（3）To step（2）80-90% ethyl alcohol is added in obtained medicinal extract to stir until determining alcohol reaches 60-75%, it is quiet
Precipitation is set, is filtered, filtrate decompression concentration removes ethyl alcohol, obtains the concentrate that the relative density at 60-65 DEG C is 1.25-1.3；
（4）By step（3）Powder, granule, oral solution or injection is made in obtained concentrate.
5. a kind of Chinese medicine composition as described in any one of claim 1-3 is in the drug for preparing treatment toxplasmosis in pigs
In application.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102715354A (en) * | 2012-06-03 | 2012-10-10 | 周剑峰 | Traditional Chinese medicine feed additive for controlling swine toxoplasmosis |
| CN103251741A (en) * | 2013-05-31 | 2013-08-21 | 张步彩 | Chinese medicine composition for treating toxoplasmosisinswine, and preparation method and application thereof |
-
2017
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102715354A (en) * | 2012-06-03 | 2012-10-10 | 周剑峰 | Traditional Chinese medicine feed additive for controlling swine toxoplasmosis |
| CN103251741A (en) * | 2013-05-31 | 2013-08-21 | 张步彩 | Chinese medicine composition for treating toxoplasmosisinswine, and preparation method and application thereof |
Non-Patent Citations (3)
| Title |
|---|
| 中草药抗弓形虫作用机制的研究进展;于朝云等;《中国血吸虫病防治杂志》;20151231;第24-25页 * |
| 中药配伍治疗急性弓形虫病的研究;万红娇等;《江西中医学院学报》;20001231;第555-557页 * |
| 桦褐孔菌不同提取物抗弓形虫效果的比较;李佳佳等;《河南农业科学》;20101231;第119-122页 * |
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