CN107927343A - A kind of additive for preventing chicken infectious anemia - Google Patents
A kind of additive for preventing chicken infectious anemia Download PDFInfo
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- CN107927343A CN107927343A CN201711243660.2A CN201711243660A CN107927343A CN 107927343 A CN107927343 A CN 107927343A CN 201711243660 A CN201711243660 A CN 201711243660A CN 107927343 A CN107927343 A CN 107927343A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
Abstract
The present invention relates to veterinary drug technical field, more particularly to a kind of additive for preventing chicken infectious anemia；Including following raw material by weight：Mushroom 15~25, root of Chinese trichosanthes 8~12, Flos Magnoliae Liliflorae 6~9, radish seed 12~18, polygonum perfoliatum 10~20, Rhizoma Polygoni sinensis 10~20, sundew 8~12, Chinese actinidia root 10~20, Cephalotaxus mannii 5~8, Chinese blister beetle 12~18, elscholtiza 2~5, Semen Lablab Album 6~9, multi-vitamins 6~12, compound amino acid 2~8；The additive of the present invention, there is significant prevention effect to chicken infectious anemia, effectively kill pathogen and its virus of infection chicken infectious anemia, at the same time, also improve the Immunoresistance of chicken, the resistance of itself is lifted, reduces the risk caught an illness, effectively improves the prevention effect of chicken infectious anemia.
Description
Technical field
The present invention relates to veterinary drug technical field, more particularly to a kind of additive for preventing chicken infectious anemia.
Background technology
Chicken cultivates the extension as agricultural industry, and highly important position is not only occupied in Chinese tradition aquaculture, and
And leading position is in the production of poultry industry always, the sound development of chicken aquaculture industry is to solve the important channel of increasing peasant income
One of, and one of ensure important sources of the carnivorous consumption of resident, development chicken aquaculture industry be promote Chinese farmers increase wealth,
The important channel of Surplus Labor Power Quantity, the stabilization supply of chicken meat product, which has become, solves increasing peasant income and national economy
Important step, but frequently-occurring and very harmful chicken infectious anemia is serious to hinder what chicken aquaculture developed in a healthy way to trip
Stone.
Chicken infectious anemia be by Chicken Infectious Anemia Virus (Chickeninfectiousanemiavirus, CIAV or
CAV a kind of immunodefiiciency disease with communicable alpastic anemia and total lymphoid atrophy, sense caused by)
Dye chicken clinically often shows as growth retardation, anaemia, exudative dermatitis, thymus gland, the bursa of farbricius, spleen, pancreas, liver,
Kidney, duodenum and cecal tonsil and its hetero-organization endolymph cell serious loss or atrophy.Infect avian infectious poor
The chicken of blood causes the horizontal obvious drop of antibody tormation since immune organ is damaged, lymphocyte quantity is reduced, breeder reaction weakens
It is low, plus cell factor regulatory function obstacle, finally there is the suppression of humoral and cellular immune response；Deng Bowen etc. is to avian infectious
Mouth is found during Anemia Immune defect mechanism study], after Chickens Infected CAV, lgA in its tear, tracheal fluid, intestinal juice and bile,
LgG, lgM, content have different degrees of decline, show to infect the Local Humoral Immunity functions such as chick eye, respiratory tract alimentary canal
It is impaired, so that infection chick increases other epidemic diseases, such as NDV, MDV, IBDV neurological susceptibility.[73 recognize NotebornMHM etc.
For the target cell of CAV infection is mainly red blood cell and lymphocyte in marrow and thymus gland, and the T of these tissues of Virus entry is thin
Born of the same parents and during erythroblast, VP3 encoding genes, which start to express A to take off, bites element；To bite plain body molecule very small and with meta-alkali because de-
Characteristic, thus can in chromatin Structure with histone or nonhistones interaction, cause DNA superhelixes be damaged and
Fracture, makes thymus cortex cell and marrow erythroblast that apoptosis occur, causes the immune deficiency and anaemia of body.
At present generally using antibiotic prevention chicken infectious anemia, there are following defect：On the one hand, prevented using antibiotic
Chicken infectious anemia, its prevention effect and unobvious, after antibiotic, the live chickens death rate caused by chicken infectious anemia is still
It is very high；Secondly, live chickens are fed using antibiotic, the antibiotic residue of live chickens is exceeded, after people eats the exceeded live chickens of antibiotic, meeting
Cause in antibiotic residue body, human body constitution is developed immunity to drugs, the exceeded live chickens of long-term consumption antibiotic make health
Into serious harm.
Chinese herbal medicine has the advantages that medicine source is extensive, the efficient, resistance to the action of a drug is not notable, toxic side effect is small at present, is passed in prevention chicken
During metachromia anaemia, in addition to having pharmacological property and trophism concurrently, also there is the work(of the production performance for improving chicken and efficiency of feed utilization
Effect, so being increasingly taken seriously, application is also increasingly extensive, so, in view of a series of features of Chinese herbal medicine, Chinese herbal medicine is used
There is positive effect in the prevention of chicken infectious anemia, be used to prevent as application number 201510622955.5 discloses one kind
The medicine of chicken infectious anemia is controlled, medicine includes following raw medicinal material：Cordate houttuynia, smallpox of ancient India, garden burnet, greater celandine, nephelium lappaceum, the leaf of bamboo
Any of several broadleaf plants, nakedflower beautyberry branchlet and leaf, ligustrum sinense, Herba Beronicastri brunoniani, arched bottom, blood-snow willow, fiveleaf akebia fruit, radix glycyrrhizae, mandarin orange leaf, cynomorium songaricum, Morinda officinalis, field grasswort,
Broom top, oval kumquat root, Ficus fulva Reinw, cassia twig, hindu lotus leaf-base, resina liquidamberis, bush, Chinese trumpet creeper, polygala, pyrola, golden sealavender flower, trailing plants Japonica
And Radix Rhodiolae Dumulosae, from existing patent with from the point of view of paper, though for chicken infectious anemia Chinese herbal and crude drugs preparations research obtain
Certain effect, but since the formula of current preparation is unreasonable, and the randomness of chicken infectious anemia morbidity and frequently-occurring etc.
Feature so that current Chinese medicine prevention effect is less desirable, causes to have occurred that incidence is very high, and cure rate is very low to be showed
As, the development of chicken aquaculture is seriously constrained, therefore, for the characteristics of incidence of chicken infectious anemia opportunistic pathogen, reduces incidence,
Chicken infectious anemia cure rate is improved, the sound development to chicken aquaculture has important practical significance and economic implications.
The content of the invention
The present invention is in order to solve the above technical problems, provide a kind of additive for preventing chicken infectious anemia.
Realized particular by following technical scheme：
A kind of additive for preventing chicken infectious anemia, including following raw material by weight：Mushroom 15~25, smallpox
Powder 8~12, Flos Magnoliae Liliflorae 6~9, radish seed 12~18, polygonum perfoliatum 10~20, Rhizoma Polygoni sinensis 10~20, sundew 8~12, Kiwi berry
Root 10~20, Cephalotaxus mannii 5~8, Chinese blister beetle 12~18, elscholtiza 2~5, Semen Lablab Album 6~9, multi-vitamins 6~12, compounded amino
Acid 2~8.
Including following raw material by weight：Mushroom 20, root of Chinese trichosanthes 10, Flos Magnoliae Liliflorae 8, radish seed 15, polygonum perfoliatum 15, chicken
Blood 7 15, sundew 10, Chinese actinidia root 15, Cephalotaxus mannii 7, Chinese blister beetle 15, elscholtiza 3, Semen Lablab Album 8, multi-vitamins 10, compound ammonia
Base acid 5.
The multi-vitamins, are by (0.2~0.8) by pantothenic acid, folic acid：(0.3~0.5).
The compound amino acid, is by (0.4~0.8) by lysine, methionine, threonine and glutamine：(0.1~
0.3)：(0.3~0.6)：The mass ratio of (0.2~0.4) is mixed to prepare.
The additive of the prevention chicken infectious anemia, its preparation method, comprises the following steps：
(1) Chinese medicine is handled：By mushroom, root of Chinese trichosanthes, Flos Magnoliae Liliflorae, radish seed, polygonum perfoliatum, Rhizoma Polygoni sinensis, sundew, Kiwi berry
Root, Cephalotaxus mannii, Chinese blister beetle, elscholtiza, Semen Lablab Album are weighed by formula ratio, after cleaning, are crushed, are added the 2~3 of the crushed material quality
Times water, heating decocts 30min, adds the ethanol of 5 times of crushed material quality amounts, microwave treatment, stand stirring 2~
4h, after recycling ethanol, remaining material is continued to heat infusion 30min, is filtered to get filtrate and filter residue；
(2) filtrate is handled：Filtrate prepared by compound amino acid, multi-vitamins and step (1) mixes, and is ultrasonically treated,
Obtain liquid；
(3) filter residue is handled：Filter residue prepared by step (1), ultramicro grinding, obtains medicinal powder.
The microwave treatment, microwave power are 600~700w, and the microwave time is 0.4~0.6h.
The supersound process, frequency are 55~65KHz, and ultrasonic time is 3~5min.
The additive of the prevention chicken infectious anemia, in use, be that first daily grain of chicken is placed in liquid, immersion 25~
35min, presses 1 after filtering drying with medicinal powder again：0.6~0.8% mass ratio mixes, and feeding is carried out to chicken.
In conclusion the beneficial effects of the present invention are：The additive of the present invention, has chicken infectious anemia significant
Prevention effect so that the average attack rate of chicken infectious anemia exists the cure rate of chicken infectious anemia 0.23% or so
More than 100%, pathogen and its virus of infection chicken infectious anemia are effectively killed, and there is broad spectrum activity, meanwhile, also improve
The Immunoresistance of chicken, lifts the resistance of itself, reduces the risk caught an illness, effectively improve the prevention of chicken infectious anemia
Effect, to improving chicken production performance, reduction economic loss, promoting chicken aquaculture sustainable and healthy development to play extremely important meaning
Justice.
Embodiment
The embodiment of the present invention is described in further detail below, but the invention is not limited in these realities
Mode is applied, any improvement or replacement on the present embodiment essence spirit, it is claimed to still fall within the claims in the present invention
Scope.
Embodiment 1
A kind of additive for preventing chicken infectious anemia, including following raw material by weight：Mushroom 15kg, root of Chinese trichosanthes
8kg, Flos Magnoliae Liliflorae 6kg, radish seed 12kg, polygonum perfoliatum 10kg, Rhizoma Polygoni sinensis 10kg, sundew 8kg, Chinese actinidia root 10kg, Hainan are thick
Chinese torreya 5kg, Chinese blister beetle 12kg, elscholtiza 2kg, Semen Lablab Album 6kg, multi-vitamins 6kg, compound amino acid 2kg；The compound dimension life
Element, is by 0.2 by pantothenic acid, folic acid：0.3；The compound amino acid, be by lysine, methionine, threonine and glutamine by
0.4：0.1：0.3：0.2 mass ratio is mixed to prepare.
The additive of the prevention chicken infectious anemia, its preparation method, comprises the following steps：
(1) Chinese medicine is handled：By mushroom, root of Chinese trichosanthes, Flos Magnoliae Liliflorae, radish seed, polygonum perfoliatum, Rhizoma Polygoni sinensis, sundew, Kiwi berry
Root, Cephalotaxus mannii, Chinese blister beetle, elscholtiza, Semen Lablab Album are weighed by formula ratio, after cleaning, are crushed, are added the 2~3 of the crushed material quality
Water again, heating decoct 30min, the ethanol of 5 times of amounts of the crushed material quality are added, under the power of 600w, at microwave
0.4h is managed, stands 2~4h of stirring, after recycling ethanol, remaining material is continued to heat infusion 30min, is filtered to get filtrate and filter residue；
(2) filtrate is handled：Filtrate prepared by compound amino acid, multi-vitamins and step (1) mixes, 55KHz's
Under frequency, 3min is ultrasonically treated, obtains liquid；
(3) filter residue is handled：Filter residue prepared by step (1), ultramicro grinding, obtains medicinal powder.
The additive of the prevention chicken infectious anemia, in use, be that first daily grain of chicken is placed in liquid, immersion
25min, presses 1 after filtering drying with medicinal powder again：0.6% mass ratio mixes, and feeding is carried out to chicken.
Embodiment 2
A kind of additive for preventing chicken infectious anemia, including following raw material by weight：Mushroom 25kg, root of Chinese trichosanthes
12kg, Flos Magnoliae Liliflorae 9kg, radish seed 18kg, polygonum perfoliatum 20kg, Rhizoma Polygoni sinensis 20kg, sundew 12kg, Chinese actinidia root 20kg, Hainan
Caephalotaxus sinensis 8kg, Chinese blister beetle 18kg, elscholtiza 5kg, Semen Lablab Album 9kg, multi-vitamins 12kg, compound amino acid 8kg；The compound dimension
Raw element, is by 0.8 by pantothenic acid, folic acid：0.5；The compound amino acid, is by lysine, methionine, threonine and glutamine
By 0.8：0.3：0.6：0.4 mass ratio is mixed to prepare.
The additive of the prevention chicken infectious anemia, its preparation method, comprises the following steps：
(1) Chinese medicine is handled：By mushroom, root of Chinese trichosanthes, Flos Magnoliae Liliflorae, radish seed, polygonum perfoliatum, Rhizoma Polygoni sinensis, sundew, Kiwi berry
Root, Cephalotaxus mannii, Chinese blister beetle, elscholtiza, Semen Lablab Album are weighed by formula ratio, after cleaning, are crushed, are added the 2~3 of the crushed material quality
Water again, heating decoct 30min, the ethanol of 5 times of amounts of the crushed material quality are added, under the power of 700w, at microwave
0.6h is managed, stands stirring 4h, after recycling ethanol, remaining material is continued to heat infusion 30min, is filtered to get filtrate and filter residue；
(2) filtrate is handled：Filtrate prepared by compound amino acid, multi-vitamins and step (1) mixes, 65KHz's
Under frequency, 5min is ultrasonically treated, obtains liquid；
(3) filter residue is handled：Filter residue prepared by step (1), ultramicro grinding, obtains medicinal powder.
The additive of the prevention chicken infectious anemia, in use, be that first daily grain of chicken is placed in liquid, immersion
35min, presses 1 after filtering drying with medicinal powder again：0.8% mass ratio mixes, and feeding is carried out to chicken.
Embodiment 3
A kind of additive for preventing chicken infectious anemia, including following raw material by weight：Mushroom 20kg, root of Chinese trichosanthes
10kg, Flos Magnoliae Liliflorae 8kg, radish seed 15kg, polygonum perfoliatum 15kg, Rhizoma Polygoni sinensis 15kg, sundew 10kg, Chinese actinidia root 15kg, Hainan
Caephalotaxus sinensis 7kg, Chinese blister beetle 15kg, elscholtiza 3kg, Semen Lablab Album 8kg, multi-vitamins 10kg, compound amino acid 5kg；The compound dimension
Raw element, is by 0.5 by pantothenic acid, folic acid：0.4；The compound amino acid, is by lysine, methionine, threonine and glutamine
By 0.6：0.2：0.5：0.3 mass ratio is mixed to prepare.
The additive of the prevention chicken infectious anemia, its preparation method, comprises the following steps：
(1) Chinese medicine is handled：By mushroom, root of Chinese trichosanthes, Flos Magnoliae Liliflorae, radish seed, polygonum perfoliatum, Rhizoma Polygoni sinensis, sundew, Kiwi berry
Root, Cephalotaxus mannii, Chinese blister beetle, elscholtiza, Semen Lablab Album are weighed by formula ratio, after cleaning, are crushed, are added the 2~3 of the crushed material quality
Water again, heating decoct 30min, the ethanol of 5 times of amounts of the crushed material quality are added, under the power of 650w, at microwave
0.5h is managed, stands 2~4h of stirring, after recycling ethanol, remaining material is continued to heat infusion 30min, is filtered to get filtrate and filter residue；
(2) filtrate is handled：Filtrate prepared by compound amino acid, multi-vitamins and step (1) mixes, 60KHz's
Under frequency, 4min is ultrasonically treated, obtains liquid；
(3) filter residue is handled：Filter residue prepared by step (1), ultramicro grinding, obtains medicinal powder.
The additive of the prevention chicken infectious anemia, in use, be that first daily grain of chicken is placed in liquid, immersion
30min, presses 1 after filtering drying with medicinal powder again：0.7% mass ratio mixes, and feeding is carried out to chicken.
Embodiment 4
A kind of additive for preventing chicken infectious anemia, including following raw material by weight：Mushroom 15kg, root of Chinese trichosanthes
12kg, Flos Magnoliae Liliflorae 6kg, radish seed 18kg, polygonum perfoliatum 10kg, Rhizoma Polygoni sinensis 20kg, sundew 8kg, Chinese actinidia root 20kg, Hainan are thick
Chinese torreya 5kg, Chinese blister beetle 18kg, elscholtiza 2kg, Semen Lablab Album 9kg, multi-vitamins 6kg, compound amino acid 2kg；The compound dimension life
Element, is by 0.2 by pantothenic acid, folic acid：0.5；The compound amino acid, be by lysine, methionine, threonine and glutamine by
0.4：0.3：0.3：0.4 mass ratio is mixed to prepare.
The additive of the prevention chicken infectious anemia, its preparation method, comprises the following steps：
(1) Chinese medicine is handled：By mushroom, root of Chinese trichosanthes, Flos Magnoliae Liliflorae, radish seed, polygonum perfoliatum, Rhizoma Polygoni sinensis, sundew, Kiwi berry
Root, Cephalotaxus mannii, Chinese blister beetle, elscholtiza, Semen Lablab Album are weighed by formula ratio, after cleaning, are crushed, are added the 2~3 of the crushed material quality
Water again, heating decoct 30min, the ethanol of 5 times of amounts of the crushed material quality are added, under the power of 600w, at microwave
0.6h is managed, stands 2~4h of stirring, after recycling ethanol, remaining material is continued to heat infusion 30min, is filtered to get filtrate and filter residue；
(2) filtrate is handled：Filtrate prepared by compound amino acid, multi-vitamins and step (1) mixes, 55KHz's
Under frequency, 5min is ultrasonically treated, obtains liquid；
(3) filter residue is handled：Filter residue prepared by step (1), ultramicro grinding, obtains medicinal powder.
The additive of the prevention chicken infectious anemia, in use, be that first daily grain of chicken is placed in liquid, immersion
25min, presses 1 after filtering drying with medicinal powder again：0.8% mass ratio mixes, and feeding is carried out to chicken.
Embodiment 5
A kind of additive for preventing chicken infectious anemia, including following raw material by weight：Mushroom 25kg, root of Chinese trichosanthes
8kg, Flos Magnoliae Liliflorae 9kg, radish seed 12kg, polygonum perfoliatum 20kg, Rhizoma Polygoni sinensis 10kg, sundew 12kg, Chinese actinidia root 10kg, Hainan are thick
Chinese torreya 8kg, Chinese blister beetle 12kg, elscholtiza 5kg, Semen Lablab Album 6kg, multi-vitamins 12kg, compound amino acid 2kg；The compound dimension life
Element, is by 0.8 by pantothenic acid, folic acid：0.3；The compound amino acid, be by lysine, methionine, threonine and glutamine by
0.8：0.3：0.6：0.4 mass ratio is mixed to prepare.
The additive of the prevention chicken infectious anemia, its preparation method, comprises the following steps：
(1) Chinese medicine is handled：By mushroom, root of Chinese trichosanthes, Flos Magnoliae Liliflorae, radish seed, polygonum perfoliatum, Rhizoma Polygoni sinensis, sundew, Kiwi berry
Root, Cephalotaxus mannii, Chinese blister beetle, elscholtiza, Semen Lablab Album are weighed by formula ratio, after cleaning, are crushed, are added the 2~3 of the crushed material quality
Water again, heating decoct 30min, the ethanol of 5 times of amounts of the crushed material quality are added, under the power of 700w, at microwave
0.4h is managed, stands 2~4h of stirring, after recycling ethanol, remaining material is continued to heat infusion 30min, is filtered to get filtrate and filter residue；
(2) filtrate is handled：Filtrate prepared by compound amino acid, multi-vitamins and step (1) mixes, 65KHz's
Under frequency, 3min is ultrasonically treated, obtains liquid；
(3) filter residue is handled：Filter residue prepared by step (1), ultramicro grinding, obtains medicinal powder.
The additive of the prevention chicken infectious anemia, in use, be that first daily grain of chicken is placed in liquid, immersion
25min, presses 1 after filtering drying with medicinal powder again：0.6% mass ratio mixes, and feeding is carried out to chicken.
1st, randomly select health status, activity can stand by force, age identical some of chicken, be randomly divided into 2 groups, every group of chicken
Quantity is identical, is fed using daily management mode, and 2 groups of chickens are fed by same people, and difference is, first group
Any additive prepared by the present embodiment 1~5 is mixed that (specific combined amount puts daily grain of chicken with reference in embodiment 1~5 with daily ration
In liquid, 25~35min is soaked, 1 is pressed with medicinal powder again after filtering drying：0.6~0.8% mass ratio mixes), chicken is carried out
Feeding, second group is added Application No. 201510622955.5 in daily ration《A kind of medicine for being used to prevent chicken infectious anemia》
Disclosed medicine, for additive amount with first group, experimental period is 3 months, is united respectively to the prevention rate of chicken infectious anemia
Meter, the results are shown in Table 1：
Table 1
| Project | Incidence % |
| First group | 0.23 |
| Second group | 1.35 |
2nd, some ages in the first year, the separation through virus and identification are randomly selected and serological test is made a definite diagnosis with avian infectious
The chicken of anaemia, is randomly divided into 2 groups, is fed using daily management mode, and is fed by same people, and difference exists
In embodiment 1~5 is prepared any additive and mixed with daily ration (by chicken in specific combined amount reference embodiment 1~5 by first group
Daily ration is placed in liquid, soaks 25~35min, 1 is pressed with medicinal powder again after filtering drying：0.6~0.8% mass ratio mixes), it is right
Chicken carries out feeding, and second group is added Application No. 201510622955.5 in daily ration《One kind is used to prevent chicken infectious anemia
Medicine》Disclosed medicine, additive amount is with first group, test period 20d, respectively to the treatment of chicken infectious anemia
Counted, the results are shown in Table 2：
Table 2
| Cure rate % | |
| First group | 100 |
| Second group | 98.5 |
3rd, clinical effectiveness
Chicken performance loss of appetite after Nanning raiser part of in August, 2015 introduces chick 1200,3 weeks from other places,
Diseased chicken spirit is depressed, ochrodermia, impaired development, and the symptom such as anaemia, serious or even dead, blood is thin, and the clotting time prolongs
Long, blood plasma is relatively normal pale.8~10 days hematocrits decline after infection, after infection 14~20 days usually 10%~
20%, some dying chickens even drop to 6%.Low hematocrit value is due to that the blood such as red blood cell, leucocyte and blood platelet are thin
Caused by born of the same parents significantly reduce, to dying of illness, chicken has carried out comprehensive inspection, changes and tests according to incidence, clinical symptoms, dissect
Room inspection is diagnosed as chicken group and has infected chicken infectious anemia.It will appear from symptom at once and do not occur the chicken isolation processing of symptom.Choosing
200 therein are taken using the additive feeding chicken in embodiment 1~5；After feeding 4 days, the spirit of chicken is clearly better, and appetite increases
Greatly, 200 diseased chickens are fully recovered after feeding 10 days.Continue to feed chicken after 7 days, compared with healthy chicken, average weight is essentially identical, controls
More rate is up to 100%.
Claims (8)
1. a kind of additive for preventing chicken infectious anemia, it is characterised in that including following raw material by weight：Mushroom 15
~25, root of Chinese trichosanthes 8~12, Flos Magnoliae Liliflorae 6~9, radish seed 12~18, polygonum perfoliatum 10~20, Rhizoma Polygoni sinensis 10~20, sundew 8~
12nd, Chinese actinidia root 10~20, Cephalotaxus mannii 5~8, Chinese blister beetle 12~18, elscholtiza 2~5, Semen Lablab Album 6~9, multi-vitamins 6~
12nd, compound amino acid 2~8.
2. as claimed in claim 1 prevention chicken infectious anemia additive, it is characterised in that including it is following by weight
Raw material：Mushroom 20, root of Chinese trichosanthes 10, Flos Magnoliae Liliflorae 8, radish seed 15, polygonum perfoliatum 15, Rhizoma Polygoni sinensis 15, sundew 10, Chinese actinidia root
15th, Cephalotaxus mannii 7, Chinese blister beetle 15, elscholtiza 3, Semen Lablab Album 8, multi-vitamins 10, compound amino acid 5.
3. the additive of prevention chicken infectious anemia as claimed in claim 1, it is characterised in that the multi-vitamins,
It is by (0.2~0.8) by pantothenic acid, folic acid：(0.3~0.5).
4. the additive of prevention chicken infectious anemia as claimed in claim 1, it is characterised in that the compound amino acid, is
Lysine, methionine, threonine and glutamine are pressed into (0.4~0.8)：(0.1~0.3)：(0.3~0.6)：(0.2~0.4)
Mass ratio be mixed to prepare.
5. the additive of prevention chicken infectious anemia as claimed in claim 1, it is characterised in that its preparation method, including with
Lower step：
(1) Chinese medicine is handled：By mushroom, root of Chinese trichosanthes, Flos Magnoliae Liliflorae, radish seed, polygonum perfoliatum, Rhizoma Polygoni sinensis, sundew, Chinese actinidia root, sea
Southern caephalotaxus sinensis, Chinese blister beetle, elscholtiza, Semen Lablab Album are weighed by formula ratio, after cleaning, are crushed, are added 2~3 times of the crushed material quality
Water, heating decoct 30min, add the ethanol of 5 times of amounts of the crushed material quality, microwave treatment, stands 2~4h of stirring, return
After receiving ethanol, remaining material is continued to heat infusion 30min, is filtered to get filtrate and filter residue；
(2) filtrate is handled：Filtrate prepared by compound amino acid, multi-vitamins and step (1) mixes, and is ultrasonically treated, obtains medicine
Liquid；
(3) filter residue is handled：Filter residue prepared by step (1), ultramicro grinding, obtains medicinal powder.
6. the additive of prevention chicken infectious anemia as claimed in claim 5, it is characterised in that the microwave treatment, it is micro-
Wave power is 600~700w, and the microwave time is 0.4~0.6h.
7. the additive of prevention chicken infectious anemia as claimed in claim 5, it is characterised in that the supersound process, frequency
Rate is 55~65KHz, and ultrasonic time is 3~5min.
8. the additive of prevention chicken infectious anemia as claimed in claim 5, it is characterised in that in use, being first by chicken day
Grain is placed in liquid, soaks 25~35min, 1 is pressed with medicinal powder again after filtering drying：0.6~0.8% mass ratio mixes, to chicken
Carry out feeding.
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| Application Number | Priority Date | Filing Date | Title |
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| CN101647852A (en) * | 2009-08-28 | 2010-02-17 | 缪雪荣 | Veterinary medicine for enhancing immunologic function |
| CN102078371A (en) * | 2009-11-27 | 2011-06-01 | 天津瑞普生物技术股份有限公司 | Pharmaceutical composition for preventing and treating chicken proventriculitis |
| CN102397528A (en) * | 2011-11-15 | 2012-04-04 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating chicken infectious anemia and preparation method thereof |
| CN104106731A (en) * | 2014-06-16 | 2014-10-22 | 邵素英 | Laying hen composite premix |
| CN105079303A (en) * | 2015-09-28 | 2015-11-25 | 宋磊 | Medicine for preventing and curing Chicken infectious anemia |
| CN106361938A (en) * | 2016-10-12 | 2017-02-01 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition for preventing and treating chicken infectious anemia and preparation method and application thereof |
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2017
- 2017-11-30 CN CN201711243660.2A patent/CN107927343A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647852A (en) * | 2009-08-28 | 2010-02-17 | 缪雪荣 | Veterinary medicine for enhancing immunologic function |
| CN102078371A (en) * | 2009-11-27 | 2011-06-01 | 天津瑞普生物技术股份有限公司 | Pharmaceutical composition for preventing and treating chicken proventriculitis |
| CN102397528A (en) * | 2011-11-15 | 2012-04-04 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating chicken infectious anemia and preparation method thereof |
| CN104106731A (en) * | 2014-06-16 | 2014-10-22 | 邵素英 | Laying hen composite premix |
| CN105079303A (en) * | 2015-09-28 | 2015-11-25 | 宋磊 | Medicine for preventing and curing Chicken infectious anemia |
| CN106361938A (en) * | 2016-10-12 | 2017-02-01 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition for preventing and treating chicken infectious anemia and preparation method and application thereof |
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