CN109498701A - A kind of Chinese medicine composition and its preparation method and application for preventing and treating goose paramyxovirus - Google Patents
A kind of Chinese medicine composition and its preparation method and application for preventing and treating goose paramyxovirus Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine compositions and its preparation method and application for preventing and treating goose paramyxovirus.The Chinese medicine composition pierces 15~45 parts by weight of barberry by 6~18 parts by weight of Phellinus, cat, and the bulk pharmaceutical chemicals of 9~27 parts by weight of Herba Thalictri Ramosi, 10~30 parts by weight of Herba Linderniae ruellioidis are made.The advantages that Chinese medicine composition of the invention has treating both manifestation and root cause of disease, and whole curative effect is high, short treating period, is not likely to produce drug resistance, and residual is low, and toxic side effect is small, for promoting the sound development of feeding goose industry, has highly important economic benefit and social benefit.
Description
Technical field
The invention belongs to herbal medicine pharmaceutical fields, are related to a kind of goose anti virus herb composition.The invention further relates to this
The application of the preparation method of Chinese medicine composition and the Chinese medicine composition in the herbal medicine of preparation prevention and treatment goose paramyxovirus.
Background technique
Goose paramyxovirus is a kind of acute infectious disease characterized by alimentary canal pathological change of goose.To the harm of goose compared with
Greatly, often cause large quantities of death, for the young goose death rate up to 90% or more, provisions goose industry causes serious economic loss.The glutinous disease of goose pair
The cause of disease of viral disease is the glutinous virus of goose, belongs to paramyxovirus section paramyxovirus category.Virus is widely present in (spleen in the internal organs of disease goose
Dirty, liver, intestinal tube etc.).It observes under an electron microscope, virion is (average diameter is 120 nanometers) not of uniform size, and form is not
Just, there is intensive fine lug structure on surface, and viral internal is wrapped in helical symmetry nucleocapsid by cyst membrane.Since goose paramyxovirus can be
It is bred in chicken embryo, isolated strain can be bred rapidly after being inoculated with 10 age in days development of chick embryo, chicken embryo death in 2~3 days after inoculation.
After goose paramyxovirus occurs, antibiotic, sulfa drugs are no therapeutic effects, viscous without prevention and treatment goose pair in the market
The Western medicine of virus, it is also seldom can to prevent and treat goose paramyxovirus herbal medicine, though there are individual plants that can prevent and treat goose paramyxovirus, but
But there is easy recurrences and the disadvantage that cannot be eradicated.And the dosage form of Chinese medicine is that powder is more, digestion and absorption is slow, takes orally
Liquid can take orally or drink water treatment, absorb fastly, make good use of.China's natural resources of Chinese medicinal materials is abundant, is clinically gone through using existing thousands of years
History, and Chinese medicine treatment can play the role for the treatment of both manifestation and root cause of disease, therefore exploitation can effectively prevent the Chinese medicine of goose paramyxovirus disease
Composition is one of the effective way for solving this field problem.
Summary of the invention
The purpose of the present invention is to provide a kind of anti-paramyxovirus Chinese medicine compositions of goose.
Another object of the present invention is to provide the above-mentioned goose preparation method of anti-paramyxovirus Chinese medicine composition.
It is a still further object of the present invention to provide Chinese medicine compositions in the herbal medicine object of preparation prevention and treatment goose paramyxovirus
Using.
The purpose of the present invention is what is implemented by following technical measures:
A kind of Chinese medicine composition for preventing and treating goose paramyxovirus, the composition are made of the bulk pharmaceutical chemicals of following parts by weight: Phellinus 6
~18 parts by weight, cat pierce 15~45 parts by weight of barberry, 9~27 parts by weight of Herba Thalictri Ramosi, 10~30 parts by weight of Herba Linderniae ruellioidis.
Above-mentioned composition is preferably made of the bulk pharmaceutical chemicals of following parts by weight: 8~12 parts by weight of Phellinus, and cat pierces barberry 15~25
Parts by weight, 11~17 parts by weight of Herba Thalictri Ramosi, 12~20 parts by weight of Herba Linderniae ruellioidis.
Above-mentioned composition is most preferably made of the bulk pharmaceutical chemicals of following parts by weight: 8~10 parts by weight of Phellinus, and cat thorn barberry 17~
20 parts by weight, 11~13 parts by weight of Herba Thalictri Ramosi, 12~15 parts by weight of Herba Linderniae ruellioidis.
Preparation, preferably oral solution is made in above-mentioned Chinese medicine composition and pharmaceutically acceptable auxiliary material.
The preparation method of the Chinese medicine composition of above-mentioned treatment goose paramyxovirus the following steps are included: by Phellinus, cat thorn barberry,
It is soaked in water after Herba Thalictri Ramosi, Herba Linderniae ruellioidis mixing, decocts 2-3 times, be concentrated into thick shape after collecting decoction, add ethyl alcohol to be adjusted to ethyl alcohol dense
Degree 60%~70%, sufficiently stirs evenly, refrigeration precipitating, filtering, filtrate recycling ethanol, and the medical fluid after recycling ethyl alcohol adds ethyl alcohol to second again
Determining alcohol 75%~80%, stirs evenly, refrigeration precipitating, filtering, and filtrate recycling ethanol is further concentrated to no alcohol taste, and medical fluid adds water cooling to hide
Precipitating, filtering, filtrate concentration.
The preparation method of the traditional Chinese medicine oral liquid of above-mentioned prevention and treatment goose paramyxovirus the following steps are included:
It soaks in water, decocts 2-3 times after Phellinus, cat thorn barberry, Herba Thalictri Ramosi, Herba Linderniae ruellioidis are mixed, it is dense after collecting decoction
It is reduced to thick shape, adds ethyl alcohol to be adjusted to concentration of alcohol 60%~70%, sufficiently stirs evenly, refrigeration precipitating, filtering, filtrate recycling ethanol, time
Medical fluid after receiving ethyl alcohol adds ethyl alcohol to stir evenly to concentration of alcohol 75%~80% again, refrigeration precipitating, filtering, filtrate recycling ethanol, then
It is concentrated into no alcohol taste, medical fluid adds water cooling hiding precipitating, filtering, and filtrate is concentrated to give the medical fluid that concentration is every mL crude drug amount Han 1~2g, system
At oral solution.
The method of the Chinese medicine composition of above-mentioned treatment goose paramyxovirus specifically: by Phellinus, cat pierces barberry, Herba Thalictri Ramosi,
Herba Linderniae ruellioidis mixing, 6~8 times of amount water immersions 8 of dosing material gross weight~for 24 hours, 0.5~1.5h is boiled and maintained, is filtered, filter residue dosing again
5~8 times of amount water of material gross weight, boil and maintain 0.5~1.5h, and filtering merges filtrate twice, is concentrated into thick shape, ethyl alcohol is added to be adjusted to
Concentration of alcohol 60%~70%, sufficiently stirs evenly, refrigeration precipitating, filtering, filtrate recycling ethanol, and the medical fluid after recycling ethyl alcohol adds second again
Alcohol stirs evenly, refrigeration precipitating, filtering, filtrate recycling ethanol is further concentrated to no alcohol taste, and medical fluid adds to concentration of alcohol 75%~80%
Water cooling hiding precipitating, filtering, filtrate concentration.
The goose is applied in prevention and treatment goose paramyxovirus infectious disease with anti virus herb composition, is had significant curative effect, can be answered
It is used to prepare the herbal medicine object of prevention and treatment goose paramyxovirus.
Beneficial effects of the present invention: the present invention draws traditional Chinese veterinary medicine marrow；Phellinus is On Polyporaceae phelliuns igniarius
The fructification of Phellinusigniarius (L.exFr) .Quel, returns liver and kidney channel, and function has hemostasis, and soft antidiarrheal is changed in promoting blood circulation.It is main
Blood strangury is controlled, rectal prolapse rushes down blood, splenasthenic diarrhea, viral infectious.Cat pierces barberry, pierces barberry for Berberidaceae plant cat
The root of Berberissoulieanaschneid returns large intestine, the heart, Liver Channel function to have heat-clearing, eliminating dampness, purging fire for removing toxin.It cures mainly damp and hot
Dysentery, diarrhea, jaundice, eczema, sore, aphtha, hot eyes, pharyngalgia.Herba Thalictri Ramosi is cohosh racemosus grass of meadow rue
The herb of ThalictrumramosumBoivin returns liver, large intestine channel, and function has heat-clearing and damp-drying drug, removing toxic substances.Cure mainly dysentery, jaundice,
Hot eyes, carbuncle swells boil.Herba Linderniae ruellioidis is long capsule Brittle Falsepimpernel Herb Linderniaanagallis (Burm.f.) prnnell's of scrophulariaceae
Herb, returns liver, the spleen channel, and function has clearing heat and detoxicating, activating blood circulation and reducing swelling.Wind-heat is cured mainly, is coughed, tonsillitis, enteritis, indigestion,
Red eye, swell pain, swollen ulcer drug, dog, snake bite, traumatic injury.
In the present composition, Phellinus is to return liver and kidney channel, and cat thorn barberry is to return large intestine, the heart, Liver Channel, and Herba Thalictri Ramosi is to return
Liver, large intestine channel, Herba Linderniae ruellioidis are to return liver, the spleen channel, and therefore, the present invention provides a kind of goose anti-paramyxovirus Chinese medicine composition, uses
Traditional Chinese medicine prescription, using the channel tropism of drug, for the goose paramyxovirus in the internal organs of sick goose, four kinds of prescription medicines are common
Synergistic effect, and combine modern traditional Chinese medicine theoretical, using cat thorn barberry as monarch drug in a prescription, four traditional Chinese medicine object compatibility there is goose paramyxovirus
Significant preventive and therapeutic effect, achievees the purpose that treating both manifestation and root cause of disease.
Pharmacodynamic test is further illustrated below to curative effect of the invention.
One, the external anti-goose paramyxovirus test of the present invention
1, drug:
(1) sample 1 of the present invention: being prepared according to 1 method of embodiment, and it is raw containing 1g to be made into every milliliter of medical fluid with physiological saline
The concentration of medicine.
(2) sample 2 of the present invention: being prepared according to 3 method of embodiment, and it is raw containing 1g to be made into every milliliter of medical fluid with physiological saline
The concentration of medicine.
(3) Western medicine compares drug: by adefovir dipivoxil capsule, being diluted to 2.5mg/mL adefovirdipivoxil ester solution.
2, goose paramyxovirus strain is provided by Yangzhou University, the HA potency 9log of chick embryo allantoic liquid2, after measured, minimum causes
Dead amount is ten thousand times of 1:100 dilutions.
3, non-chicken embryo of exempting from is purchased from Yangzhou Yizheng kind chicken house.
4, test grouping chicken embryo 50, the specific situation that is grouped are shown in Table 1.
5, test method
(1) Drug toxicity trails by sample of the present invention 1 and sample 2 of the present invention respectively with normal saline dilution, by stoste and
The medical fluid of various concentration is inoculated in respectively in the allantoic cavity of 3 instar chicken embryos on the 10th, every 0.2mL, sets 37.8 DEG C of incubations
72h observes survival condition daily, and the highest liquor strength that chicken embryo is all survived is formal experiment initial concentration, while setting physiology
Saline control group, drug are shown in Table 2 to embryonic toxicity experimental result.
1 experimental group situation of table
2 Chinese medicine of table is to embryonic toxicity experimental result
* denominator is inoculation embryo number, and molecule is survival embryo number.
(2) drug of the present invention measures the inhibiting effect of goose paramyxovirus virus, specific method:
The test each chick embryo allantoic cavity of I group is inoculated with 1 medical fluid 0.2mL of sample, viral dilution 0.1mL of the present invention simultaneously.
It tests II group of each chick embryo allantoic cavity while being inoculated with 2 medical fluid 0.2mL of sample, viral dilution 0.1mL of the present invention.
The test each chick embryo allantoic cavity of III group is inoculated with the Aldoforwe ester 0.2mL of 2.5mg/mL, viral dilution simultaneously
0.1mL。
The each chick embryo allantoic cavity of positive controls is inoculated with physiological saline 0.2mL, viral 0.1mL simultaneously.
Blank control group not virus inoculation, is not administered.
Above-mentioned chicken embryo continues to hatch in 37.8 DEG C of insulating boxs, shines egg 2~3 times daily, discards dead germ in for 24 hours, collects 24
The allantoic fluid of~72h dead germ and 72h embryo living, cryo-conservation are spare.The virus effect of detection chick embryo allantoic liquid is tested with blood clotting (HA)
Valence.
The influence that drug of the present invention is proliferated goose paramyxovirus virus, the results are shown in Table 3.
The inhibiting effect measurement result that the drug of the present invention of table 3 is proliferated goose paramyxovirus virus
Compared with positive controls: P < 0.01 * P < 0.05, * *
Two, therapeutic test of the present invention to experimental goose paramyxovirus
1, experimental animal: this test is randomly divided into 14 groups with 25 age in days young bird geese 420, and every group 30, i.e., sample of the present invention
1 (preparing by embodiment 2) prevention group and treatment group, sample of the present invention 2 (are prepared, when use is diluted to every milliliter and contains by embodiment 4
1g crude drug concentration) prevention group and treatment group, sample of the present invention 3 (barberry is pierced only with Chinese medicine cat, is prepared according to 2 method of embodiment,
Every milliliter of concentration of crude drug containing 1g is diluted to when use) prevention group and treatment group, sample of the present invention 4 (only with Chinese medicine Herba Thalictri Ramosi,
Prepared by 2 method of embodiment, when use is diluted to every milliliter of concentration of crude drug containing 1g) prevention group and treatment group, sample 5 of the present invention
When use (only with Chinese medicine Herba Linderniae ruellioidis, prepared by 2 method of embodiment, be diluted to every milliliter of concentration of crude drug containing 1g) prevention group with control
Treatment group, Western medicine prevention group and treatment group infect control group, blank control group.
2, goose paramyxovirus strain is provided by Yangzhou University, and the HA potency of chick embryo allantoic liquid is 9log2。
3, test method:
(1) allantoic fluid minimum lethal dose is first measured, the minimum lethal dose of allantoic fluid is 1000 times of dilutions, every goose after measured
Intramuscular injection allantoic fluid 0.5mL.
(2) operate: the goose not medication of blank control group is not inoculated with allantoic fluid, remaining 13 groups goose is every in the same time
Intramuscular injection allantoic fluid 0.5mL.
(3) administrated method and curative effect 1 prevention group of sample of the present invention start while being inoculated with allantoic fluid with sample of the present invention
1 is oral, and 4d is used in conjunction in each 2mL of every goose, daily medication 2 times.1 treatment group of sample of the present invention (occurs after being inoculated with allantoic fluid 4d
Symptom) medication, each 2mL of every goose, 4d is used in conjunction in daily medication 2 times.2 prevention group of sample of the present invention is same inoculation allantoic fluid
When, oral with sample 2 of the present invention, 4d is used in conjunction in each 2mL of every goose, daily medication 2 times；2 treatment group of sample of the present invention is being inoculated with
4d is used in conjunction in the medication that (symptom occurs) after allantoic fluid 4d, each 2mL of every goose, daily medication 2 times.3 prevention group of sample of the present invention exists
While being inoculated with allantoic fluid, oral with sample 3 of the present invention, 4d is used in conjunction in each 2mL of every goose, daily medication 2 times；Sample of the present invention
4d is used in conjunction in medication that 3 treatment group of product (symptom occurs) after being inoculated with allantoic fluid 4d, each 2mL of every goose, daily medication 2 times.This hair
Bright 4 prevention group of sample is oral with sample 4 of the present invention while being inoculated with allantoic fluid, each 2mL of every goose, daily medication 2 times,
4d is used in conjunction；4 treatment group of sample of the present invention (symptom occurs) after being inoculated with allantoic fluid 4d medication, each 2mL of every goose, daily medication
2 times, 4d is used in conjunction.For 5 prevention group of sample of the present invention while being inoculated with allantoic fluid, oral with sample 5 of the present invention, every goose is each
2mL, daily medication 2 times, is used in conjunction 4d；5 treatment group of sample of the present invention (symptom occurs) after being inoculated with allantoic fluid 4d medication, every goose
Each 2mL, daily medication 2 times, is used in conjunction 4d.Aldoforwe ester prevention group is while being inoculated with allantoic fluid, with the A De of 50mg/mL
Good fortune Wei ester is oral, and 4d is used in conjunction 2 times a day in every goose 1mL.(there is disease after being inoculated with allantoic fluid 4d in Aldoforwe ester treatment group
Shape), with the Aldoforwe ester drug therapy of 50mg/mL, each 1mL of every goose is oral, 2 times a day, 4d is used in conjunction.Infect control group
Goose be only inoculated with allantoic fluid, do not have to any drug, the results are shown in Table 4.
4 goose paramyxovirus prevention and treatment result of table
| Number | Group | Inoculation number/only | Morbidity number/only | Rehabilitation number/only | Death toll/only | Cure rate/% |
| 1 | 1 prevention group of sample of the present invention | 30 | 0 | 28 | 2 | 93.3 |
| 2 | 1 treatment group of sample of the present invention | 30 | 30 | 26 | 4 | 86.6 |
| 3 | 2 prevention group of sample of the present invention | 30 | 0 | 29 | 1 | 96.6 |
| 4 | 2 treatment group of sample of the present invention | 30 | 30 | 27 | 3 | 90.0 |
| 5 | 3 prevention group of sample of the present invention | 30 | 15 | 20 | 10 | 66.6 |
| 6 | 3 treatment group of sample of the present invention | 30 | 30 | 18 | 12 | 60.0 |
| 7 | 4 prevention group of sample of the present invention | 30 | 13 | 21 | 9 | 70.0 |
| 8 | 4 treatment group of sample of the present invention | 30 | 30 | 19 | 11 | 63.3 |
| 9 | 5 treatment group of sample of the present invention | 30 | 25 | 14 | 16 | 46.6 |
| 10 | 5 treatment group of sample of the present invention | 30 | 30 | 11 | 19 | 36.6 |
| 11 | Aldoforwe ester prevention group | 30 | 16 | 19 | 11 | 63.3 |
| 12 | Aldoforwe ester treatment group | 30 | 30 | 16 | 14 | 53.3 |
| 13 | Infect control group | 30 | 30 | 0 | 30 | — |
| 14 | Blank control group | 30 | 0 | 30 | 0 | 100 |
Three, clinical observation of the present invention to goose paramyxovirus treatment
The incubation period of goose paramyxovirus disease is generally 3-5 days, small young goose 2-3 days of age in days, big goose 3-6 days of age in days.Disease
Goose performance spirit is depressed, and appetite stimulator, necking down peels off, and is slow in action, drowsiness not search for food, but drinks water like not reducing, and initial stage, row was light
Yellow green, canescence, egg white sample loose stool；After being in a bad way, excrement is in kermesinus, green or blackish green, is mixed with bubble.Walking nothing
Power is reluctant to be lauched, or keeps afloat, and floats with water.It has difficulty in breathing, gets rid of head cough, a small amount of serosity secretion is flowed out in nostril
Object, beak end and edge color are dimmed.The course of disease later period partially suffers from goose performance and turns round neck, turn-take, face upward head, and two legs paralysis cannot stand, with
After twitch and dead, the course of disease it is long because that thin malnutrition is gathered and exhausted is dead, the sick goose in part can survive recovery from illness, but growth and development is not
It is good.Young goose is often dead in 1-2 days after the onset, young goose, sick and slightly long at goose, and generally 3-5 days.
(preparation of embodiment 4 is pressed, when use is diluted to sample of the present invention 1 (preparing by embodiment 2) and sample of the present invention 2
Every milliliter of concentration of crude drug containing 1g), every goose takes orally 2mL every time, and daily medication twice, is used in conjunction 4 days.In the East Platform county in Jiangsu, treasured
Ying County, Haian County, Jiangdu of Yangzhou City area carry out drug therapy test to morbidity goose, the results are shown in Table 5, table 6.
The sample 1 of the present invention of table 5 is to goose paramyxovirus clinical efficacy result
| Unit | Number of cases/only | The healing of sample 1 number/only | Death toll/only | Cure rate/% |
| East Platform county goose field | 915 | 857 | 58 | 93.6 |
| Baoying County's goose field | 423 | 382 | 41 | 90.3 |
| Haian County's goose field | 316 | 291 | 25 | 92.1 |
| Jiangdu area goose field | 512 | 456 | 56 | 89.1 |
| It is total | 2166 | 1986 | 180 | 91.7 |
The sample 2 of the present invention of table 6 is to goose paramyxovirus clinical efficacy result
| Unit | Number of cases/only | The healing of sample 2 number/only | Death toll/only | Cure rate/% |
| East Platform county goose field | 731 | 647 | 84 | 88.5 |
| Baoying County's goose field | 419 | 395 | 24 | 94.2 |
| Haian County's goose field | 578 | 527 | 51 | 91.1 |
| Jiangdu area goose field | 387 | 361 | 26 | 93.3 |
| It is total | 2115 | 1930 | 185 | 91.2 |
As it can be seen that more than 4,000 example of drug therapy goose paramyxovirus made by the present invention, acquirement good therapeutic effect, general treatment
Stop death after 2d, can cure after 3~4d, not recurred generally after healing, shows that present invention treatment goose paramyxovirus has very high treatment
Effect.
Four, safety evaluatio
ICR mouse 30 are taken, weight is randomly divided into 5 groups at 25~30 grams, by weight, and every group 6, half male and half female takes orally
Solutions for administration (is prepared) by embodiment 2, and dosage is respectively 0.2 milliliter/, 0.4 milliliter/, 0.6 milliliter/and 0.8
Milliliter/only, it is 2 times oral daily, it successive administration 5 days, is observed continuously after drug withdrawal 20 days.Control group free water.As a result all small
Mouse is strong to deposit, and activity, diet, hair, excreta are no abnormal, have no toxic reaction.To murine oral and damaged skin into
Row irritation test there are no irritative response and other adverse reactions.
Specific embodiment:
The invention will be further described combined with specific embodiments below:
Embodiment 1:
Prescription: Phellinus 8g, cat pierce barberry 17g, Herba Thalictri Ramosi 11g, Herba Linderniae ruellioidis 12g
Specific preparation process is as follows: Phellinus, cat thorn barberry, Herba Thalictri Ramosi, Herba Linderniae ruellioidis mixed, 6 times of dosing material gross weight
Water decocts 2 times after impregnating 24 hours, and each amount of water is 6 times of medicinal material gross weight amounts, is maintained 1 hour after boiling every time, is filtered, and merges
Filtrate is simultaneously concentrated into thick shape, and add weight percent concentration is that be adjusted to determining alcohol be 60% to 95% ethyl alcohol, and mixing is sufficiently stirred, and refrigerates
It staticly settles 48 hours or more, filters, filtrate recycling ethanol, the medical fluid after recycling ethyl alcohol adds concentration to be that 95% ethyl alcohol is adjusted to again
Determining alcohol is 80%, is stirred evenly, and refrigeration staticly settles 48 hours, is filtered, and filtrate recycling ethanol is further concentrated to no alcohol taste, to obtaining
Medical fluid in plus its 4 times amount water coolings hiding precipitating 48 hours, filtering, filtrate concentration, obtain concentration as the medical fluid of every mL 1.5g containing crude drug,
It adjusts pH7.0, oral solution is made, dispense, sterilize to obtain the final product.
Embodiment 2:
Prescription: Phellinus 10g, cat pierce barberry 15g, Herba Thalictri Ramosi 12g, Herba Linderniae ruellioidis 12g
Specific preparation process is as follows: Phellinus, cat thorn barberry, Herba Thalictri Ramosi, Herba Linderniae ruellioidis mixed, 8 times of dosing material gross weight
Water decocts 2 times after impregnating 24 hours, and each amount of water is 8 times of medicinal material gross weight amounts, is maintained 0.5 hour after boiling every time, is filtered, and closes
And filtrate and it being concentrated into thick shape, add weight percent concentration is that be adjusted to determining alcohol be 60% to 95% ethyl alcohol, and mixing is sufficiently stirred, cold
Hiding staticly settles 48 hours or more, filters, filtrate recycling ethanol, and the medical fluid after recycling ethyl alcohol adds concentration to be 95% ethyl alcohol tune again
It is 75% to determining alcohol, stirs evenly, refrigeration staticly settles 48 hours, filters, and filtrate recycling ethanol is further concentrated to no alcohol taste, Xiang get
To medical fluid in plus its 4 times amount water coolings hiding precipitating 48 hours, filtering, filtrate concentration, obtain concentration as the medical fluid of every mL 1g containing crude drug,
It adjusts pH7.0, oral solution is made, dispense, sterilize to obtain the final product.
Embodiment 3:
Prescription: Phellinus 8g, cat pierce barberry 25g, Herba Thalictri Ramosi 17g, Herba Linderniae ruellioidis 20g
Specific preparation process is as follows: Phellinus, cat thorn barberry, Herba Thalictri Ramosi, Herba Linderniae ruellioidis mixed, 4 times of dosing material gross weight
Water decocts 2 times after impregnating 30 hours, and each amount of water is 4 times of medicinal material gross weight amounts, is maintained 0.5 hour after boiling every time, is filtered, and closes
And filtrate and it being concentrated into thick shape, add weight percent concentration is that be adjusted to determining alcohol be 65% to 95% ethyl alcohol, and mixing is sufficiently stirred, cold
Hiding staticly settles 48 hours or more, filters, filtrate recycling ethanol, and the medical fluid after recycling ethyl alcohol adds concentration to be 95% ethyl alcohol tune again
It is 80% to determining alcohol, stirs evenly, refrigeration staticly settles 48 hours, filters, and filtrate recycling ethanol is further concentrated to no alcohol taste, Xiang get
To medical fluid in plus its 4 times amount water coolings hiding precipitating 48 hours, filtering, filtrate concentration, obtain concentration as the medical fluid of every mL 2g containing crude drug,
It adjusts pH7.0, oral solution is made, dispense, sterilize to obtain the final product.
Embodiment 4:
Prescription: Phellinus 12g, cat pierce barberry 20g, Herba Thalictri Ramosi 11g, Herba Linderniae ruellioidis 12g
Specific preparation process is as follows: Phellinus, cat thorn barberry, Herba Thalictri Ramosi, Herba Linderniae ruellioidis mixed, 5 times of dosing material gross weight
Water decocts 2 times after impregnating 27 hours, and each amount of water is 5 times of medicinal material gross weight amounts, is maintained 0.5 hour after boiling every time, is filtered, and closes
And filtrate and it being concentrated into thick shape, add weight percent concentration is that be adjusted to determining alcohol be 70% to 95% ethyl alcohol, and mixing is sufficiently stirred, cold
Hiding staticly settles 48 hours or more, filters, filtrate recycling ethanol, and the medical fluid after recycling ethyl alcohol adds concentration to be 95% ethyl alcohol tune again
It is 80% to determining alcohol, stirs evenly, refrigeration staticly settles 48 hours, filters, and filtrate recycling ethanol is further concentrated to no alcohol taste, Xiang get
To medical fluid in plus its 4 times amount water coolings hiding precipitating 48 hours, filtering, filtrate concentration obtains concentration as the medicine of every mL 1.5g containing crude drug
Liquid adjusts pH7.0, oral solution is made, and dispenses, sterilizes to obtain the final product.
Claims (8)
1. it is a kind of prevent and treat goose paramyxovirus Chinese medicine composition, it is characterised in that the composition by following parts by weight bulk pharmaceutical chemicals system
At: 6~18 parts by weight of Phellinus, cat pierce 15~45 parts by weight of barberry, 9~27 parts by weight of Herba Thalictri Ramosi, 10~30 weight of Herba Linderniae ruellioidis
Part.
2. the Chinese medicine composition of prevention and treatment goose paramyxovirus according to claim 1, it is characterised in that the composition is by following
The bulk pharmaceutical chemicals of parts by weight are made: 8~12 parts by weight of Phellinus, cat thorn 15~25 parts by weight of barberry, 11~17 parts by weight of Herba Thalictri Ramosi,
12~20 parts by weight of Herba Linderniae ruellioidis.
3. the Chinese medicine composition of prevention and treatment goose paramyxovirus according to claim 1, it is characterised in that the composition is by following
The bulk pharmaceutical chemicals of parts by weight are made: 8~10 parts by weight of Phellinus, cat thorn 17~20 parts by weight of barberry, 11~13 parts by weight of Herba Thalictri Ramosi,
12~15 parts by weight of Herba Linderniae ruellioidis
4. preventing and treating the Chinese medicine composition of goose paramyxovirus according to right 1,2 or 3, it is characterised in that the Chinese medicine composition
Preparation is made with pharmaceutically acceptable auxiliary material.
5. preventing and treating the Chinese medicine composition of goose paramyxovirus according to right 4, it is characterised in that the dosage form is oral solution.
6. a kind of preparation method of the Chinese medicine composition of prevention and treatment goose paramyxovirus described in claim 1,2 or 3, it is characterised in that
Method includes the following steps:
It is soaked in water after Phellinus, cat thorn barberry, Herba Thalictri Ramosi, Herba Linderniae ruellioidis are mixed, decocts 2-3 times, be concentrated into after collecting decoction
Thick shape adds ethyl alcohol to be adjusted to concentration of alcohol 60%~70%, sufficiently stirs evenly, refrigeration precipitating, filtering, and filtrate recycling ethanol recycles second
Medical fluid after alcohol adds ethyl alcohol to concentration of alcohol 75%~80% again, stirs evenly, refrigeration precipitating, filtering, filtrate recycling ethanol, then is concentrated
To no alcohol taste, medical fluid adds water cooling hiding precipitating, filtering, filtrate concentration.
7. preventing and treating the preparation method of the traditional Chinese medicine oral liquid of goose paramyxovirus described in a kind of claim 5, it is characterised in that the party
Method the following steps are included:
It is soaked in water after Phellinus, cat thorn barberry, Herba Thalictri Ramosi, Herba Linderniae ruellioidis are mixed, decocts 2-3 times, be concentrated into after collecting decoction
Thick shape adds ethyl alcohol to be adjusted to concentration of alcohol 60%~70%, sufficiently stirs evenly, refrigeration precipitating, filtering, and filtrate recycling ethanol recycles second
Medical fluid after alcohol adds ethyl alcohol to concentration of alcohol 75%~80% again, stirs evenly, refrigeration precipitating, filtering, filtrate recycling ethanol, then is concentrated
To no alcohol taste, medical fluid adds water cooling hiding precipitating, filtering, and filtrate is concentrated to give the medical fluid that concentration is every mL crude drug amount Han 1~2g, adjusts
Oral solution is made in pH7.0.
8. the Chinese medicine composition of prevention and treatment goose paramyxovirus described in claim 1,2 or 3 is in preparation prevention and treatment goose paramyxovirus
Application in veterinary drug object.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811633658.0A CN109498701A (en) | 2018-12-29 | 2018-12-29 | A kind of Chinese medicine composition and its preparation method and application for preventing and treating goose paramyxovirus |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109045127A (en) * | 2018-10-15 | 2018-12-21 | 江苏农牧科技职业学院 | A kind of application of pharmaceutical composition in prevention and treatment infectious bronchitis of chicken |
-
2018
- 2018-12-29 CN CN201811633658.0A patent/CN109498701A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109045127A (en) * | 2018-10-15 | 2018-12-21 | 江苏农牧科技职业学院 | A kind of application of pharmaceutical composition in prevention and treatment infectious bronchitis of chicken |
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