CN105663546B - Traditional Chinese medicine composition for treating proventriculitis of chicken - Google Patents
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention relates to a veterinary drug, in particular to a traditional Chinese medicine composition for treating chicken proventriculitis. The medicine of the invention consists of codonopsis pilosula, cinnamon, astragalus, bighead atractylodes rhizome, endothelium corneum gigeriae galli, betel nut, montmorillonite, cuttlebone, cortex moutan and liquorice. Relevant experiments show that the traditional Chinese medicine composition has the functions of warming yang for dispelling cold, strengthening spleen and replenishing qi, benefiting liver and invigorating stomach, and removing necrotic tissue and promoting granulation, can warm yang for dispelling cold, replenishing qi for invigorating spleen, promoting digestion and enhancing digestion functions, can reduce swelling and eliminate stagnation, promote blood circulation for removing blood stasis, remove necrotic tissue and promote granulation to repair injured glandular and gastric tissues, has no toxic or side reaction, and is suitable for treating chicken proventriculitis.
Description
Technical Field
The invention relates to a veterinary drug, in particular to a traditional Chinese medicine composition for treating chicken proventriculitis.
Background
The chicken proventriculitis is a poultry infectious syndrome disease which is mainly characterized by poor growth, emaciation and poor regularity of chicken, swollen gland and stomach like milky spherical, ulcer, desquamation and muscle and stomach erosion of gland and stomach mucosa.
When the disease occurs suddenly, the chickens often show low heads, listlessness, decreased feed intake and white feces discharge. In the middle and later period of the disease, the excrement is often found to contain undigested feed, the body of the sick chicken becomes obviously thin, the whole body is pale, and finally the sick chicken may become fatigued and killed. After some sick chickens recover, the normal growth of the sick chickens is difficult to recover, the uniformity of chicken flocks becomes worse, and the weight of the sick chickens is reduced by 15 to 36 percent compared with that of normal chickens.
The proventriculitis of chicken mainly affects the muscular stomach, thereby affecting the digestion, absorption and production performance of chicken. Can be generated in laying hens and broilers of different varieties and different ages of days, and reported varieties comprise roman, Hissajou, halan, Decka, Esha, Beijing white and AA broilers, including 817 broilers and the like. Secondly, the egg chicks and young chickens have more and more serious diseases, and then the broiler cocks and the hybrid broilers. The morbidity of the diseased region can reach 100 percent, generally 7 to 28 percent, and the mortality of the diseased region is 3 to 95 percent, generally 30 to 50 percent. The earliest onset day age is found in 7-8 days of age, and 15-50 days of age is the multiple stage. Chickens around 80 days old develop the disease less, but the disease is reported to develop in 100 days old chickens. Laying hens are reported to develop diseases. The disease course is 10-15 days, the long one can reach 35 days, and the death peak is 5-8 days after the disease. If diseases such as escherichia coli, mycoplasma, newcastle disease, coccidiosis, enteritis and the like are generated secondarily, the death rate is increased.
The disease is not seasonal, can occur all the year round, but is most severe in autumn and winter, and is sporadic. The popularity is wide, and the propagation speed is high. In the susceptibility of various chicks of 7-10 days old, the chicks with lower brooding room temperature are more likely to have diseases, the mortality rate is low, and the mortality rate is increased due to secondary diseases such as escherichia coli, mycoplasma, newcastle disease, coccidiosis, enteritis and the like after the diseases.
The chicken proventriculitis is a disease which appears in recent years, and due to complex etiology and multiple etiologies, the true etiology of the disease is not determined so far, and the chicken proventriculitis caused by multiple etiologies is one of the most difficult diseases to diagnose and treat clinically. Modern research believes that it is mainly caused by pathogenesis: 1. the oral medicament is used together with a plurality of unreasonable antibiotics; 2. environmental stress: the temperature of the chicken house is too high in the early stage, and the humidity in the chicken house is too high; 3. nutritional factors: the salt content in the feed is too high, so that the water intake of chicken flocks is higher; 4. the mould content of the large raw material in the feed is higher than 5%, and the temperature of drinking water during brooding is lower than the temperature of a house by more than 10 ℃.
At present, no ideal treatment method and no specific medicine exist in western medicine for treating chicken proventriculitis. Commonly used drugs are antibiotics and sulfonamides. However, the blinded use of antibiotics will also inhibit or kill many non-pathogenic bacterial flora and destroy their constitutive structure, seriously affecting the digestive function of the body and aggravating the disease; in addition, the long-term use of a large amount of antibiotics is easy to generate drug resistance. Chemical drugs, antibiotics and monomer drugs are abused greatly, so that various drug-induced diseases such as multi-drug resistance, receptor hypersensitivity and the like are generated, and the pollution of livestock and poultry products is caused, thereby endangering the health and safety of human food. The traditional Chinese medicine is derived from animals, plants and mineral substances, contains various biological effective components, most of the traditional Chinese medicines are prepared from natural plants, and have the advantages of abundant resources, easy acquisition, good effect, low price, small toxic and side effects, almost no residue, no drug resistance and no environmental pollution. Therefore, the selection of the traditional Chinese medicine preparation to replace chemical medicines and antibiotics is very important.
Disclosure of Invention
The invention aims to solve the technical problem of overcoming the existing defects and provides the traditional Chinese medicine composition for treating the chicken proventriculitis, which has high cure rate and small toxic and side effects and is not easy to generate drug resistance.
In order to solve the technical problems, the invention provides the following technical scheme:
the traditional Chinese medicine composition for treating proventriculitis of chicken comprises the following medicines in parts by weight: 110 parts of codonopsis pilosula 130, 65-55 parts of cinnamon, 55-45 parts of astragalus membranaceus, 44-36 parts of bighead atractylodes rhizome, 55-45 parts of endothelium corneum gigeriae galli, 44-36 parts of betel nut, 44-36 parts of montmorillonite, 44-36 parts of cuttlebone, 55-45 parts of cortex moutan and 33-27 parts of liquorice.
The medicine comprises the following components in parts by weight: 120 parts of codonopsis pilosula, 60 parts of cinnamon, 50 parts of astragalus membranaceus, 40 parts of bighead atractylodes rhizome, 50 parts of endothelium corneum gigeriae galli, 40 parts of betel nut, 40 parts of montmorillonite, 40 parts of cuttlebone, 50 parts of cortex moutan and 30 parts of liquorice.
The specific administration method comprises the following steps: pulverizing the raw materials, sieving, mixing, and feeding with feed at a dose of 1-3g per feather, 1 time per day for 5-7 days.
The specific administration method comprises the following steps: soaking the medicine in hot water of 90 deg.C above with water amount 2 times of the medicine weight, stirring, soaking for 24 hr, filtering, and adding 2-4ml of medicinal liquid into each chicken.
The weight of the chicken is within 1Kg, and the dosage of the chicken is 1g per feather.
The sieved particle size is 80 mesh.
The compound medicine of the invention comprises:
codonopsis pilosula: has sweet taste and mild property, and has effects of invigorating spleen and replenishing qi, invigorating spleen and benefiting lung, resisting cancer, lowering blood pressure, resisting anoxia, resisting aging, enhancing immunity, improving activity of superoxide dismutase, enhancing free radical scavenging ability, regulating gastrointestinal motility, resisting ulcer, inhibiting gastric acid secretion, and reducing pepsin activity.
Cinnamon: pungent and sweet in flavor and strongly hot in nature. It enters kidney, spleen, heart and liver meridians. Has the effects of supplementing fire and supporting yang, guiding fire to the origin, dispelling cold and relieving pain, and activating blood and stimulating the menstrual flow. It is used to tonify primordial yang, warm spleen and stomach, remove cold accumulation, and promote blood circulation. It is indicated for decline of vital gate fire, cold limbs, slight pulse, abdominal pain, diarrhea, and hernia of cold type.
Astragalus root: sweet in nature and warm in taste. It enters lung and spleen meridians. Has the effects of invigorating qi, consolidating exterior, promoting urination, expelling toxin, expelling pus, healing sore and promoting granulation. Can be used for treating deficiency of qi, asthenia, anorexia, loose stool, collapse of middle-warmer energy, chronic diarrhea, rectocele, edema due to qi deficiency, cellulitis, intractable ulcer, blood deficiency, and flaccidity and jaundice.
White atractylodes rhizome: bitter and sweet in taste and warm in nature. It enters spleen and stomach meridians. Has the effects of strengthening spleen, tonifying qi, eliminating dampness and promoting diuresis. Can be used for treating spleen deficiency, anorexia, abdominal distention, and diarrhea.
Endothelium corneum gigeriae galli: sweet in flavor and neutral in nature. It enters spleen, stomach, small intestine and bladder meridians. Has the effects of invigorating stomach, promoting digestion, arresting seminal emission and relieving enuresis. Can be used for treating dyspepsia, emesis, and dysentery.
Betel nut: pungent flavor and warm nature. It enters stomach and large intestine meridians. Has the effects of expelling parasites, removing food retention, promoting qi circulation, removing water retention, and preventing malaria. Can be used for treating parasitic infestation, food stagnation, abdominal pain, dysentery, edema, and malaria.
Montmorillonite: sweet in taste; and (4) temperature. It enters liver, stomach and kidney meridians. Has effects in removing toxic materials, dispersing pathogen accumulation, removing necrotic tissue, promoting granulation, dispelling cold, eliminating dampness, benefiting liver, invigorating stomach, promoting blood circulation, and dispelling blood stasis. Can be used for treating chronic hepatitis, gastritis, dysentery, and red swelling due to trauma.
Cuttlebone sheath: salty and astringent taste, slightly warm in nature. It enters liver and kidney meridians. Has effects of astringing to stop bleeding, arresting seminal emission, stopping leukorrhagia, relieving hyperacidity, and healing sore, and can be used for treating stomach ache, acid regurgitation, hematemesis, epistaxis, hematemesis, hematochezia, abdominal pain, abdominal mass, deficient malaria, dysentery, and ulcer.
Cortex moutan: bitter, pungent and slightly cold. It enters heart, liver and kidney meridians. Has the functions of promoting blood circulation to disperse blood clots. It can be used for treating carbuncle, swelling, sore, traumatic injury, and pain.
Licorice root: neutral in nature and neutral in flavor enter heart, lung, spleen and stomach meridians. Has the effects of invigorating spleen and replenishing qi, relieving spasm and pain, and harmonizing the drugs.
Square solution: the medicine of the invention uses the codonopsis pilosula to tonify the middle-jiao and qi, strengthen the spleen and harmonize the stomach; cinnamon has the effects of tonifying fire and supporting yang, guiding fire to the origin, dispelling cold and relieving pain, tonifying primordial yang, warming spleen and stomach, removing cold accumulation and promoting blood circulation, and the two medicines are monarch medicines. Radix astragali has effects of invigorating spleen qi, healing sore, promoting granulation, promoting urination, expelling toxin, and expelling pus; the largehead atractylodes rhizome has the effects of strengthening spleen and tonifying qi, and eliminating dampness and inducing diuresis; endothelium corneum Gigeriae Galli has effects of invigorating stomach, resolving food stagnation, and relieving dyspepsia; the betel nut kills parasites and removes stagnation, relieves distension and pain, and induces diuresis to treat dysentery; the four medicines are used as ministerial medicines. Montmorillonite has effects of removing toxic substance, resolving hard mass, removing necrotic tissue, promoting granulation, dispelling cold, eliminating dampness, benefiting liver, invigorating stomach, promoting blood circulation, and removing blood stasis;
stopping bleeding, relieving hyperacidity and healing sore; the root bark of the peony tree promotes blood circulation to remove blood stasis, and the three medicines are adjuvant medicines. Licorice root, radix Glycyrrhizae, as a guiding drug, has the effects of tonifying the spleen and qi, relieving spasm and pain, and harmonizing the effects of the other drugs in the recipe.
The Chinese veterinarian is dynamic medicine with the characteristic of the side-emphasis syndrome and is the essential application for adjusting the function balance of the visceral organs of the body. Firstly, from the analysis of the symptoms of proventriculitis of chicken, the chicken has the symptoms of hair pricking, heaping (cold), anorexia, diarrhea, growth retardation, early adenogastric wall edema and the like. This is due to the cold aggravation damaging yang, cold limbs, and the appearance of hair pricks and piles; spleen qi is weak due to cold-dampness encumbering the spleen, and the transportation and transformation are unable to be done, so that the patient has anorexia and overfeeding; edema of the glandular stomach wall occurs due to the dysfunction of the spleen in transportation and water retention. Lesions of other organs appear in the middle and late stages of the disease. The symptoms are manifested in the liver and lungs. The relative hyperactivity of liver qi occurs due to the weakness of spleen qi, so that the spleen yang is damaged, the fire of the gate of life is weakened, the fire is not in place, and the weakness of lung qi also causes the deficiency of lung qi due to the weakness of spleen qi, so that the mother disease and the son are transferred in the same direction, and the spleen yang deficiency is caused by the three factors entering the spleen. The pattern of spleen-yang deficiency refers to the condition of spleen-yang deficiency failing to warm and transport and yin-cold failing to generate internally. Also known as the spleen deficiency cold syndrome and the middle jiao deficiency cold syndrome. This syndrome is usually further developed due to the deficiency of spleen qi, and is usually caused by the damage of spleen yang, decline of vital gate fire and loss of fire to earth due to feed factors or cold and cool drugs.
The Chinese medicinal composition is obtained by matching the raw materials. Relevant experiments show that the traditional Chinese medicine composition has the functions of warming yang for dispelling cold, strengthening spleen and replenishing qi, benefiting liver and invigorating stomach, and removing necrotic tissue and promoting granulation, can warm yang for dispelling cold, replenishing qi for invigorating spleen, promoting digestion and enhancing digestion functions, can reduce swelling and eliminate stagnation, promote blood circulation for removing blood stasis, remove necrotic tissue and promote granulation to repair injured glandular and gastric tissues, has no toxic or side reaction, and is suitable for treating chicken proventriculitis.
The medicine of the invention contains a plurality of traditional Chinese medicines, has strong antivirus function, warms yang and dispels cold, supplements qi and strengthens spleen, removes food retention and stimulates appetite, and has strong mucosa repair function and immunity enhancement. Has no residue, drug resistance and toxic and side effects, and is a specific medicine for treating chicken proventriculitis.
The invention has the advantages and beneficial effects that 1, the invention adopts the traditional Chinese medicine veterinary therapy, adopts pure traditional Chinese medicine components, and orally takes the following traditional Chinese medicines, so that the chicken can be quickly cured after taking the traditional Chinese medicine, has no side effect, and is beneficial to the growth of the chicken. 2. The traditional Chinese medicine compound of the invention has the advantages of simple preparation, convenient use, low raw material cost, no toxic reaction after use, high cure rate and no residue, and is an ideal medicine for treating chicken proventriculitis.
Detailed Description
The traditional Chinese medicine composition for treating proventriculitis of chicken is characterized by comprising the following medicines in parts by weight: 110 parts of codonopsis pilosula 130, 65-55 parts of cinnamon, 55-45 parts of astragalus membranaceus, 44-36 parts of bighead atractylodes rhizome, 55-45 parts of endothelium corneum gigeriae galli, 44-36 parts of betel nut, 44-36 parts of montmorillonite, 44-36 parts of cuttlebone, 55-45 parts of cortex moutan and 33-27 parts of liquorice.
The optimal mixture ratio is that the medicine composition comprises the following components in parts by weight: 120 parts of codonopsis pilosula, 60 parts of cinnamon, 50 parts of astragalus membranaceus, 40 parts of bighead atractylodes rhizome, 50 parts of endothelium corneum gigeriae galli, 40 parts of betel nut, 40 parts of montmorillonite, 40 parts of cuttlebone, 50 parts of cortex moutan and 30 parts of liquorice.
The specific administration method comprises the following steps: pulverizing the raw materials, sieving, mixing, and feeding with feed at a dose of 1-3g per feather, 1 time per day for 5-7 days. The weight of the chicken is within 1Kg, and the dosage of the chicken is 1g per feather. The sieved particle size is 80 meshes.
The specific administration method comprises the following steps: soaking the medicine in hot water of 90 deg.C above with water amount 2 times of the medicine weight, stirring, soaking for 24 hr, filtering, and adding 2-4ml of medicinal liquid into each chicken.
Example 1
The traditional Chinese medicine composition for treating proventriculitis of chicken is characterized by comprising the following medicines in parts by weight: 110 parts of codonopsis pilosula, 55 parts of cinnamon, 45 parts of astragalus membranaceus, 36 parts of bighead atractylodes rhizome, 45 parts of endothelium corneum gigeriae galli, 36 parts of betel nut, 36 parts of montmorillonite, 36 parts of cuttlebone, 45 parts of cortex moutan and 27 parts of liquorice.
Example 2
The traditional Chinese medicine composition for treating proventriculitis of chicken is characterized by comprising the following medicines in parts by weight: 130 parts of codonopsis pilosula, 65 parts of cinnamon, 55 parts of astragalus membranaceus, 44 parts of bighead atractylodes rhizome, 55 parts of endothelium corneum gigeriae galli, 44 parts of betel nut, 44 parts of montmorillonite, 44 parts of cuttlebone, 55 parts of cortex moutan and 33 parts of liquorice.
Example 3
The traditional Chinese medicine composition for treating proventriculitis of chicken is characterized by comprising the following medicines in parts by weight: 120 parts of codonopsis pilosula, 60 parts of cinnamon, 50 parts of astragalus membranaceus, 40 parts of bighead atractylodes rhizome, 50 parts of endothelium corneum gigeriae galli, 40 parts of betel nut, 40 parts of montmorillonite, 40 parts of cuttlebone, 50 parts of cortex moutan and 30 parts of liquorice.
3 groups of sick chickens are selected, each group contains 30 feather, the medicines of the examples 1-3 are respectively fed, the medicine is fed for 1 time every day for 5-7 days, if the sick chickens are not healed, the medicine is continuously fed for 1-2 days, and the result shows that the sick chickens in the three groups are all recovered.
The optimal mixture ratio is that the medicine composition comprises the following components in parts by weight: 120 parts of codonopsis pilosula, 60 parts of cinnamon, 50 parts of astragalus membranaceus, 40 parts of bighead atractylodes rhizome, 50 parts of endothelium corneum gigeriae galli, 40 parts of betel nut, 40 parts of montmorillonite, 40 parts of cuttlebone, 50 parts of cortex moutan and 30 parts of liquorice.
The specific administration method comprises the following steps: pulverizing the raw materials, sieving, mixing, and feeding with feed at a dose of 1-3g per feather, 1 time per day for 5-7 days. The weight of the chicken is within 1Kg, and the dosage of the chicken is 1g per feather. The sieved particle size is 80 meshes.
The specific administration method comprises the following steps: soaking the medicine in hot water of 90 deg.C above with water amount 2 times of the medicine weight, stirring, soaking for 24 hr, filtering, and adding 2-4ml of medicinal liquid into each chicken.
Clinical efficacy test
The invention adopts a random double-blind test method to carry out different dose (high, medium and low) clinical treatment tests on diseased chicken groups for diagnosing the chicken proventriculitis, and selects cimetidine + penicillin as a positive drug control group. The therapeutic effect of the traditional Chinese medicine composition on the proventriculitis of the chicken is observed so as to discuss the feasibility of the application of the traditional Chinese medicine composition in the production of livestock and poultry.
Diagnostic criteria
The clinical characteristics are that the mental depression and the appetite are reduced, the chicken grow badly, get thin and have poor regularity, the head is often lowered, the spirit is cachectic, the feed intake is reduced, the discharged excrement is whitish, and the sick chicken become obviously thin with undigested feed. The primary characteristics of adenogastric enlargement like milk white sphere, adenogastric mucosa ulcer, abscission and muscular stomach erosion are examined by dissection.
The chickens with natural onset confirmed by clinical diagnosis are randomly divided into 5 groups, and each group has 30 feathers. Groups 1-3 are groups treated with the drug of the present invention (three groups of low, medium and high doses, respectively); group 4 is a cimetidine + penicillin positive drug control group; group 5 was a positive control group (infected, not dosed). Respectively keeping the chickens in isolation, and recording the symptoms, cure, death and the like of the sick chickens in detail.
Experimental group for treating proventriculitis of chicken
Mode of administration
Calculating the dosage according to the number of sick chickens, and after uniformly stirring the tested medicine and a small amount of concentrated feed, naturally feeding the sick chickens for medicine taking; for sick chickens incapable of eating the medicine naturally, the tested medicine is added with a little water and mixed, and then the mixture is irrigated to administer the medicine. The administration is carried out 1 time before feeding every day, the administration is continued for 5 days, and the observation is continued for 3 days after stopping the administration. After administration, the test chicken was given the option to eat and drink water.
Drug 1 group: feeding sick chickens with the dosage of 1 g/feather for 5 days; drug 2 group: the feeding amount of sick chickens is 2 g/feather, and the sick chickens are fed for 5 days continuously; drug 3 group: the feeding amount of sick chickens is 3 g/feather, and the sick chickens are fed for 5 days continuously. Positive drug control group: feeding cimetidine and penicillin (used according to the specification) to each chicken every day for 5 days; positive control group: no drug was administered.
Observation index
During the clinical trial period, namely before administration, during administration and within 3d after drug withdrawal, the clinical symptoms, activity, appetite reduction or improvement, body temperature increase, general symptoms such as spirit and the like, death, pathological anatomy and the like of the experimental chicken are observed and recorded every day.
Therapeutic results
The experimental results are as follows: after the treatment group is fed with the medicine for 24 hours, the spirits of the sick chicken in the medicine group are better than those of the positive control group, the death number is counted after 36 hours, and the death number of the sick chicken in the medicine group is obviously less than that of the positive control group; after 48 h, the improvement of each group of the medicines is observed to different degrees, and the positive control group still dies successively. After 5 days, the spirit and appetite of the drug group chickens are greatly improved (seen from the increase of the feeding amount), and the feces are normal.
Experimental results of chicken proventriculitis treatment
The experimental statistics result shows that 28 feathers of 30 feather sick chickens treated by the medicament in high dose are cured, 2 feathers are listened, the feed intake is lower than normal, the discharged excrement is white but not dead, and the cure rate is 93.3 percent; in 30-feather sick chickens in the medium-dose treatment group, 27 feathers are cured, 3 feathers are listened, the feed intake is lower than normal, the discharged excrement is white but does not die, and the cure rate is 90.0 percent; in the low-dose treatment group of 30 feather sick chickens, 22 feathers are cured, 6 feathers are listened, the feed intake is lower than normal, the discharged excrement is white, the 2 feathers die, and the cure rate is 73.3 percent; in 30 sick chickens in the cimetidine + penicillin treatment group (control group), 25 feathers are cured, 4 feathers are listless, the feed intake is lower than normal, the discharged excrement is white, 1 feather is dead, and the cure rate is 83.3 percent; in the positive control group (not administered), 30-feather sick chickens had 24 feathers which were still listened, the feed intake was lower than normal, and the discharged feces were whitish and died with 6 feathers.
The mortality of the high and medium dose treatment groups is 0.00%, and compared with the control group sick chicken, the treatment group shows that the symptoms are reduced, the disease course is shortened, experiments prove that the high, medium and low doses of the invention have the treatment effect on chicken proventriculitis, can relieve the symptoms and reduce the mortality, and the high and medium doses are better than the effects of cimetidine and penicillin on the aspects of reducing the mortality, improving the cure rate and the like. The invention can achieve the effects of treating diseases and improving the survival rate by high and medium dosages, and the two dosages have no difference on the level of 0.05, so the invention can adopt the medium dosage in clinical use, thereby having economic and obvious curative effects.
From the test results, the traditional Chinese medicine composition has the functions of warming yang and dispelling cold, invigorating spleen and replenishing qi, benefiting liver and invigorating stomach, reducing swelling and resolving masses, promoting blood circulation by removing blood stasis, and removing necrotic tissue and promoting granulation. No adverse reaction of the medicine is found in the clinical test process. The high, medium and low dosage has better treatment effect on the chicken proventriculitis, and the high and medium dosage has better treatment effect than the treatment effect of cimetidine and penicillin. The low-dose group has lower treatment effect than the high-dose group and the medium-dose group, and the medium-dose group and the high-dose group have no significant difference in mortality, cure rate and total effective rate. According to the severity of the disease and the treatment cost, the clinical application is preferably the medium dosage (chicken, 2g, (half of chicken) 1 time/d, and the mixture is taken) for 5-7 days.
Toxicity test
In order to determine the toxic and side effects of the invention, so as to make accurate and objective evaluation on the safety of the invention, provide scientific basis for clinical trial medication and ensure the safety of clinical medication, the toxicity test of the invention is carried out.
1. Acute toxicity test. Selecting 45 healthy ordinary-grade Kunming mice with the weight of 18-22g, randomly dividing the mice into 3 groups, wherein each group comprises 15 mice with half male and female, fasting (without water prohibition) for 12h before the test, and carrying out the test after feeding for 5 d. The administration was carried out by gavage, and the administration amount was 5g/kg body weight in the low dose group of group 1, 10g/kg body weight in the medium dose group of group 2, and 20g/kg body weight in the high dose group of group 3, and the administration was continuously observed for 7 days. The mice did not die during the test, and there were no abnormal changes in spirit, appetite, skin, secretions, eyes, respiration, etc. On day 8, two mice were randomly sacrificed by dislocation of cervical vertebrae, and heart, liver, spleen, lung and kidney were observedAnd gastrointestinal, with no macroscopic pathological changes. When the drug concentration is 1.2g/mL and the maximum administration volume of the gavage is 0.06mL/g, the dead dose of the mouse cannot be found, and no toxic reaction occurs, so that LD cannot be detected50。
2. Maximum tolerated dose test. Since the LD of the present invention could not be detected50Thus, the maximum tolerability test was used to study the toxicity of the drug of the invention to rats. Healthy mice were selected at 30, 18-22g, male and female halves. The experiment is carried out after the conventional breeding for 5 days, the rat is fasted but not forbidden to water for 12 hours before the experiment, the stomach is infused for 3 times according to 0.6mL/10g within 24 hours, the feeding is carried out for 8 days after the administration, and the rat has the symptoms of slight discomfort, gathering, no love for activity, reduced feed intake and the like in the observation period of 8 days except for 2 hours after each administration, and the rat has better mental status, normal feed and drinking, active movement, sensitive reaction and no morbidity and death at other times. After killing on day 8, the viscera of each group of rats have no pathological changes, and histological examination of liver, kidney and spleen does not find pathological features, and the maximum tolerance is more than 180 g/kg.
In order to master the toxic and side effects and severity caused by continuous use of the Chinese herbal medicine compound, and the development and recovery after drug withdrawal, reference is provided for drawing up the clinical safe dosage. A subacute toxicity test is carried out on rats, 80 SD rats are randomly divided into 4 groups, each group comprises 20 rats, each group comprises half of male and female rats, and the rats are raised in cages, and each cage comprises 5 rats. The first group is a high-dose group, and the daily drug filling amount is 20 g/kg; the second group is a medium dosage group, the daily medicine filling amount is 10g/kg, the third group is a low dosage group, and the daily medicine filling amount is 5 g/kg; the third group was a control group, which was continuously filled with drinking water of the same amount as the high dose group for 28 days. As a result, through observation of the appearance signs and behavior activities of SD rats, measurement of weight change, detection of hematology indexes and blood biochemistry indexes, and examination of rat organ coefficients and pathological histology of main organs, the administration group (high dose and low dose) of the invention has no significant difference with the control group. The results show that the invention is safe in clinical application.
Table 1 effect of the invention on rat body weight (
S), unit: g
TABLE 2 Effect of the invention on the hematological indices of rats: (
±s）
The effect of the present invention on the hematological indices of rats is shown in table 2. The hematology indexes of each administration group have no significant difference (P is more than 0.05) compared with the control group, and the result shows that the invention has no significant influence on each hematology index of the rat.
TABLE 3 Biochemical index assay of rat blood according to the invention: (
±s）
The biochemical index test results of the blood of each group of rats after 14d of administration are shown in Table 3. Through statistical analysis, the blood biochemical indexes of each administration group have no significant difference (P is more than 0.05) compared with the control group, and the result shows that the invention has no significant influence on various biochemical indexes of rats.
In the test period, except that the high-dose group affects the food intake due to poor palatability caused by large drug dose, rats in other groups have normal diet, behavior and feces, good development and no toxic symptom, and the weight gain and nutrition have no significant difference except that the high-dose group and the control group have significant difference. The blood general index and blood biochemical index of each group of rats were within the normal range. Histological examination shows that the liver, the kidney, the spleen and the like have no obvious pathological changes. The preparation is infused into the stomach for 30 days according to the clinical dosage of 5-10 times, and has no toxic or side effect, which indicates that the clinical dosage of the preparation is very safe.
Claims (1)
1. The traditional Chinese medicine composition for treating proventriculitis of chicken is characterized by comprising the following medicines in parts by weight: 120 parts of codonopsis pilosula, 60 parts of cinnamon, 50 parts of astragalus membranaceus, 40 parts of bighead atractylodes rhizome, 50 parts of endothelium corneum gigeriae galli, 40 parts of betel nut, 40 parts of montmorillonite, 40 parts of cuttlebone, 50 parts of cortex moutan and 30 parts of liquorice;
the specific administration method comprises the following steps: pulverizing the raw materials, sieving, mixing, and feeding with mixed feed at a dose of 1-3g per feather, 1 time per day for 5-7 days, wherein the sieved particle size is 80 mesh;
or the specific administration method is as follows: soaking the medicine in hot water of 90 deg.C above with water amount 2 times of the medicine weight, stirring, soaking for 24 hr, filtering, and adding 2-4ml of medicinal liquid into each chicken.
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| CN106214736B (en) * | 2016-08-08 | 2020-04-28 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition for treating chicken proventriculitis and preparation method and application thereof |
| CN111558011A (en) * | 2020-06-15 | 2020-08-21 | 山西中医药大学 | Traditional Chinese veterinary medicine for preventing and treating chicken proventriculitis |
| CN112741892B (en) * | 2021-01-26 | 2022-06-07 | 河北牧安动物药业有限公司 | Traditional Chinese medicine composition for preventing and treating poultry myoglandular gastritis, oral liquid and preparation method |
| CN113082140B (en) * | 2021-05-12 | 2022-10-14 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine compound for treating acute mastitis of dairy cows and preparation method thereof |
| CN114306567A (en) * | 2022-03-04 | 2022-04-12 | 山东省农业科学院家禽研究所（山东省无特定病原鸡研究中心） | Traditional Chinese medicine oral liquid for preventing and treating chicken glandular myositis |
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| CN102078371A (en) * | 2009-11-27 | 2011-06-01 | 天津瑞普生物技术股份有限公司 | Pharmaceutical composition for preventing and treating chicken proventriculitis |
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