CN110090279A - It is a kind of prevent and treat fowl gout Chinese medicine composition and its preparation, application method - Google Patents
It is a kind of prevent and treat fowl gout Chinese medicine composition and its preparation, application method Download PDFInfo
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
Abstract
The invention belongs to field of traditional Chinese veterinary, more particularly to a kind of Chinese medicine composition for preventing and treating fowl gout, the Chinese medicine composition includes 1.5-2 parts of smilax, 1-2 parts of sophora flower, 1-2 parts of Lygodium japonicum, 1-1.5 parts of caulis akebiae, 0.5-1 parts of the coptis, 1-2 parts of Radix Glycyrrhizae, 0.5-1 parts of Radix Astragali, 0.5-1 parts of hawthorn and 0.5-1 parts of Divine Comedy according to parts by weight.Beneficial effects of the present invention: 1, the present invention has chosen to the preferable smilax of xanthine oxidase inhibitory effect and sophora flower, can effectively inhibit the generation of uric acid；2, Chinese medicine composition is pure Chinese medicinal preparation, is easy to be absorbed, reliable, highly-safe, drug residue free for the treatment of fowl goat significant effect, effect；3, Chinese medicine composition of the invention is preferably powder type, convenient for production storage and uses, can promote and apply.
Description
Technical field
The invention belongs to field of traditional Chinese veterinary, and in particular to it is a kind of prevent and treat fowl gout Chinese medicine composition and its preparation, use
Method.
Background technique
Fowl gout be cause uric acid in blood content significantly to increase since fowl uric acid generates excessive or excretion disorder, and then with
Lithate is deposited on joint capsule, articular cartilage, periarticular, one in splanchnocoel and various organ surfaces and other interstitial tissues
Kind disease.It is clinically slow in action with sick fowl, leg is characterized with conjunctura enlargement, anorexia, limping, weak and diarrhea.Its pathology
It is characterized in that uric acid in blood level increases；Articular surface or visceral surface are seen when pathology dissect has a large amount of white lithates heavy
Product.Gout can be divided into joint type gout and two kinds of visceratonia gout.Or so the 1990s, Britain and U.S. etc. will all lay eggs
Group's death of chicken is attributed to gout.China's major part fowl gout is batch, and the death rate is higher, sometime up to 30%,
Huge economic loss is brought to aquaculture.Moreover, the trend that the generation of this disease also increases in recent years, especially intensive feeding
Feeding chicken group.In aquatic bird, the higher chicken of protein content is fed frequent occurrence, the young goose gout that duck diet causes, therefore, fowl gout
Up to the present one of poultry diease still more typical for China.
Clinical treatment fowl gout is the Allopurinol class drug for inhibiting uric acid to generate and promotion uric acid using more drug
The Benzbromarone of excretion.But such drug side-effect is larger, and long-time service will lead to pharmacological dependence effect, reduces poultry
The quality and safety of meat, egg product.Xanthine oxidase (Xanthine oxidase, XOD) is one in nucleic acid in vivo metabolism
Kind important enzyme is widely present in cow's milk, the liver of birds and kidney, insect, in bacterium.XOD can be catalyzed xanthine and time Huang
The oxidation of purine generates uric acid, and uric acid concentration is excessively high to will lead to hyperuricemia, and then causes gout.Reduce internal xanthine oxidase
The activity for changing enzyme, can reduce the formation of uric acid.Generally acknowledged xanthine oxidase inhibitor mainly has in the world: allopurinol, fast
Purine class xanthine oxidase inhibitor, non-purines xanthine oxidase inhibitor and other xanthine oxidase inhibitors.State
The xanthine oxidase inhibitor of interior research mainly has: xanthine oxidase inhibitor in Chinese medicine, xanthine in Chinese medicine compound prescription
Oxidase inhibitor and food source.Xanthine oxidase inhibitor is the key agents for treating hyperuricemia and gout, people
Curing clinically most commonly used is allopurinol, but the long-time service of this kind of drug is larger to the damage of kidney.It would therefore be highly desirable to grind
The xanthine oxidase inhibitor drug for sending out new.Wang Xiaomei etc. has found that rhizoma alismatis, caulis sinomenii and Angelica Dahurica extract have stronger body
The active effect of outer inhibition XOD, Li Xiangcheng etc. have found that Gentrin Knotweed P.E is inhibited to XOD, mention for research XOD inhibitor
Foundation is supplied.Chinese medicine Small side effects, it is from a wealth of sources, it is easily obtained and prepares, therefore find xanthine oxidase suppression from Chinese medicine
Preparation for treating fowl gout has become the emphasis of people's research.
To disease prevention and treatment, really fruitful method is very few at present, such as with allopurinol treatment to reduce uric acid generation, but should
Method is at high cost, on the other hand since the ammonia synthesized in vivo cannot be efficiently converted into uric acid, can also cause new adverse consequences.Also
The composition of some prevention and treatment fowl goats, but its therapeutic effect or undesirable, or do not investigate, there are uncertainties, using doubtful
Consider high and indefinite to the function and effect of the aquatic birds such as goose.Exploitation scientific compatibility, ingredient is simple and effective, preparation method is simple
Chinese medicine composition is poultry industry urgent problem.
Summary of the invention
To solve the above-mentioned problems, the object of the present invention is to provide a kind of Chinese medicine composition for preventing and treating fowl gout, the Chinese medicines
Composition is mixed with basal feed, is kept fowls, and gout in poultry can be significantly prevented and treated.
The present invention provides the following technical solutions:
A kind of Chinese medicine composition for preventing and treating fowl gout, the Chinese medicine composition includes smilax 1.5-2 according to parts by weight
Part, 1-2 parts of sophora flower, 1-2 parts of Lygodium japonicum, 1-1.5 parts of caulis akebiae, 0.5-1 parts of the coptis, 1-2 parts of Radix Glycyrrhizae, 0.5-1 parts of Radix Astragali, hawthorn
0.5-1 parts and Divine Comedy 0.5-1 parts.
Preferably, 1.5 parts of smilax, 1 part of sophora flower, 1 part of Lygodium japonicum, 1 part of caulis akebiae, 0.5 part of the coptis, 1 part of Radix Glycyrrhizae, Radix Astragali
0.5 part, 0.5 part of hawthorn and 0.5 part of Divine Comedy.
Preferably, 2 parts of smilax, 2 parts of sophora flower, 2 parts of Lygodium japonicum, 1.5 parts of caulis akebiae, 1 part of the coptis, 2 parts of Radix Glycyrrhizae, 1 part of Radix Astragali,
1 part and 1 part of Divine Comedy of hawthorn.
Preferably, the Chinese medicine composition is powder or decoction.
The present invention also provides a kind of preparation method of Chinese medicine composition for preventing and treating fowl gout, the preparation methods of the powder
To crush above-mentioned each Chinese medicinal component respectively, after crossing 40-60 mesh sieve, it is uniformly mixed according to the proportion relation of claim 1, i.e.,
Powder is made；
The preparation method of the decoction is to crush above-mentioned Chinese medicinal component respectively, mixed according to the proportion relation of claim 1
Coarse powder is made in conjunction, is extracted using water extraction, mentions for the first time according to coarse powder, water quality than extracting for the ratio of 1:20
Taking temperature is 75 DEG C, extraction time 1.5h, is extracted for the second time according to coarse powder, water quality than extracting for the ratio of 1:10
Temperature is 75 DEG C, extraction time 1h, collects extract, cooled and filtered twice and is concentrated in vacuo to filtrate, is made
The extract solution of 0.5g/mL, obtains decoction.
The present invention also provides it is a kind of prevent and treat fowl gout Chinese medicine composition application method, by the Chinese medicine composition with
It after basal feed mixes, keeps fowls, the weight of the Chinese medicine composition is the 1%-2% of basic feed relative.
Preferably, the basal feed is 1-21 age in days gosling feed or 1-20 Day-old Broiler Chickens feed or 21-48 days
Age broiler fodder；
If 1-21 age in days gosling feed, include by weight, 36.4-46 parts of corn, 13.79-15 parts of wheat wheat-middlings,
17.06-20 parts of rice bran, 7.35-14.7 parts of albumen powder, 4 parts of corn germ cake, 8-9 parts of vinasse albumen feed, 0.72 part of mountain flour,
3 parts and one 2.28 parts of premix of corn protein powder；The premix one provides for every kilogram of feed: 140,000 IU of vitamin A, dimension
Raw 60,000 IU of element D3, vitamin E 100IU, Vitamin K3 28mg, vitamin B1 12mg, vitamin B2 62mg, vitamin B6
18mg, vitamin B12 0.12mg, pantothenic acid 100mg, niacin 3180mg, folic acid 11.6mg, biotin 1.6mg, choline 5000mg,
Mn 900mg, Zn 1000mg, Fe 1.3g, Cu 250mg, Se 4.5mg, I 7mg, lysine 25000mg；
It if 1-20 Day-old Broiler Chickens feed, by weight include 57.06 parts of corn, 29.58 parts of dregs of beans, zein
6 parts of powder, 3.6 parts of soybean oil, 0.27 part of lysine, 0.1 part of sodium humate, 0.1 part of montmorillonite, 1.22 parts of mountain flour, calcium monohydrogen phosphate
0.8 part, 0.27 part of salt and 21 parts of premix；The premix two provides for every kilogram of feed: methionine 1925mg, choline
1000mg, Mold adsorbent 500mg, speed solution enzyme 500mg, threonine 1050mg, phytase 120mg, rice bran meal 29050mg；
It if 21-48 Day-old Broiler Chickens feed, by weight include 31.17-66.47 parts of corn, dregs of beans 20.68-
50.24 parts, 6-9 parts of corn protein powder, 2.7-6.1 parts of soybean oil, 0-0.66 parts of lysine, 0.1 part of sodium humate, montmorillonite
0.1 part, 1.22 parts of mountain flour, 0.8 part of calcium monohydrogen phosphate, 0.27 part of salt and 31 parts of premix；The premix three is every kilogram of feeding
Material provides: methionine 1550mg, choline 700mg, Mold adsorbent 500mg, threonine 850mg, tryptophan 100mg, pure beet
Alkali 1250mg, phytase 120mg, rice bran meal 23050mg.
The beneficial effects of the present invention are:
1, the present invention selects the effect of raw material as follows:
Smilax: nature and flavor: it is sweet light, it puts down.Channel tropism: Liver Channel, stomach meridian, the spleen channel.Removing toxic substances, dehumidifying, sharp joint.Nature and flavor: it is sweet light,
It is flat.The major functions: control syphilis, stranguria with turbid discharge, muscles and bones contraction pain, tinea pedis treats furunculosis, carbuncle swells, scrofula, and limbs caused by syphilis and mercury poisoning are arrested
Contraction, arthralgia and myalgia.
Sophora flower: channel tropism: Liver Channel, lung channel, the heart channel of Hang-Shaoyin, large intestine channel.Function: cooling blood and hemostasis is clear liver and improved vision.The major functions: hematochezia,
Blood under hemorrhoid, bloody flux, hematuria, blood strangury, metrorrhagia and metrostaxis are spitted blood, bleeding from five sense organs or subcutaneous tissue, the headache of liver heat, red eye, swell pain, carbuncle swells sore.
Lygodium japonicum: it is sweet, salty, it trembles with fear.Channel tropism: bladder, small intestinl channel.Major function: eliminating dampness and heat, treating stranguria analgesic are used for heat gonorrhea,
Sand leaching, urolithiasis, blood strangury, cream leaching, Urethra astringent pain
Caulis akebiae: nature and flavor: bitter, slightly cold.Channel tropism: enter the heart channel of Hang-Shaoyin, small intestinl channel, bladder meridian.Major function: inducing diuresis for treating strangurtia, clears away heart-fire and removes
It is tired, it is newborn under promoting menstruation.
The coptis: nature and flavor: bitter, it is cold in nature.Channel tropism: return heart, spleen, stomach, liver, gallbladder, large intestine channel.Effect: heat-clearing and damp-drying drug, purging intense heat solution
Poison.
Radix Glycyrrhizae: nature and flavor sweet and neutral.Channel tropism: return heart, lung, spleen, stomach meridian.Major function: invigorating the spleen and benefiting qi, clearing heat and detoxicating, eliminating the phlegm stops
Cough, relieving spasm to stop pain, coordinating the drug actions of a prescription.Major function: weakness of the spleen and the stomach, fatigue and weakness, shortness of breath and palpitation, coughing with a lot of sputum, stomach duct and abdomen, four limbs contraction
Anxious pain, carbuncle sore tumefacting virus alleviate drug toxicity, strong.
Radix Astragali: nature and flavor: sweet, tepor.Channel tropism: return lung, spleen, liver and kidney channel.Effect: exterior deficiency spontaneous perspiration, night sweat due to yin deficiency, acute kidney
Scorching oedema, oedema due to chronic nephritis, spleen kidney deficiency, yang-energy is weak, and the deficiency of vital energy is weak, sore ulceration, syndrome of deficiency of lung qi, and the deficiency of vital energy is weak.
Hawthorn: nature and flavor acid is sweet, tepor.Channel tropism: enter spleen, stomach, Liver Channel.Major function: digestion gathered food, scattered blood stasis, expelling tenia disappear
Stomach invigorating is eaten, scattered stasis is used for meat stagnation, gastric ulcer fullness, diarrhea dysentery abdominal pain, blood stasis closed, postpartum stasis, confidant sting, hernia
Gas pain, hyperlipemia.
Divine Comedy: nature and flavor: sweet, acrid, warm.Channel tropism: returns spleen, stomach meridian.Effect: strengthening the spleen and stomach, promoting digestion and removing indigestion.
The present invention be used to prevent and treat fowl gout Chinese medicine composition be according to theory of traditional Chinese medical science, the meridian distribution of property and flavor of Chinese medicine and effect,
Carry out diagnosis and treatment on the basis of Overall View, including smilax, sophora flower, Lygodium japonicum, caulis akebiae, the coptis, Radix Glycyrrhizae, Radix Astragali, hawthorn,
The kinds of traditional Chinese medicines such as Divine Comedy, with diuresis fossil, strengthening spleen and nourishing stomach is objective.Smilax, coptis removing dampness and detoxicating benefit joint；Sophora flower cool blood is stopped
Blood clears liver and improve vision；Lygodium japonicum, caulis akebiae inducing diuresis for treating strangurtia；Radix Astragali solution exterior deficiency；Hawthorn, Divine Comedy digesting and appetizing；Radix Glycyrrhizae coordinating the drug actions of a prescription.
2, the present invention has chosen to the preferable smilax of xanthine oxidase inhibitory effect and sophora flower, can effectively inhibit to urinate
The generation of acid.
3, Chinese medicine composition is pure Chinese medicinal preparation, is easy to be absorbed, prevent and treat fowl goat significant effect, effect reliable, is pacified
Quan Xinggao, drug residue free.
4, Chinese medicine composition of the invention is preferably powder type, convenient for production storage and uses, can promote and apply.
5, each Chinese medicinal component of the present invention is resourceful, at low cost；The fowl for having strict technology standard and quality standard is made
With antigout pure Chinese medicine feed addictive, have and prevent and treat effect well, and the growth performance of poultry can be improved.
Detailed description of the invention
Figure 1A is the liver organization figure of normal goose；
Figure 1B is the liver organization figure of gout goose；
Fig. 2A is the liver organization figure of normal chicken；
Fig. 2 B is the liver organization figure of gout chicken；
Fig. 3 A is goose gout figure；
Fig. 3 B is goose gout figure；
Fig. 3 C is goose gout figure；
Fig. 3 D is goose gout figure.
Specific embodiment
The present invention is illustrated combined with specific embodiments below.
Embodiment 1
A kind of Chinese medicine composition preventing fowl gout, the Chinese medicine composition include smilax 1.5 according to parts by weight
Part, 1 part of sophora flower, 1 part of Lygodium japonicum, 1 part of caulis akebiae, 0.5 part of the coptis, 1 part of Radix Glycyrrhizae, 0.5 part of Radix Astragali, 0.5 part of hawthorn and Divine Comedy 0.5
Part.
Embodiment 2
A kind of Chinese medicine composition for treating fowl gout, the Chinese medicine composition include according to parts by weight, 2 parts of smilax,
2 parts of sophora flower, 2 parts of Lygodium japonicum, 1.5 parts of caulis akebiae, 1 part of the coptis, 2 parts of Radix Glycyrrhizae, 1 part of Radix Astragali, 1 part of hawthorn and 1 part of Divine Comedy.
The foundation of fowl Gout Model
The present invention causes this theory of fowl gout easily with the basal feed containing high protein as starting point.
90 1 age in days young bird geese are randomly divided into 3 groups, every group 30, the basis that the 1st group of feeding protein content is 16% is raised
Expect, the basal feed that the basal feed that the 2nd group of feeding protein content is 20%, the 3rd feeding protein content are 24%.Feeding
14th day, the 3rd group was successfully caused goose Gout Model.See attached drawing 1A, 1B, 3A, 3B, 3C and 3D.
150 7 age in days white feather hybrid broilers are divided into 4 groups, every group 30, the 1st group of feeding protein content is 21%
Basal feed, the basal feed that the 2nd group of feeding protein content is 24%, the base that the 3rd group of feeding protein content is 27%
Plinth feed, the basal feed that the 4th group of feeding protein content is 30%, the 4th group of test the 14th day is successfully produced Gout Model.See
Attached drawing 2A, 2B.
Prophylactic tria
1 age in days young bird goose is randomly divided into 3 groups by case one, and every group 30, the basis that the 1st group of feeding protein content is 16%
Basal feed that feed, the 2nd group of feeding protein content are 24%, the 3rd group by protein content be 24% basal feed with
Chinese medicine composition prepared by embodiment 1 is fed after evenly mixing, and the weight of the Chinese medicine composition is basic feed relative
1%, blood drawing detection serum uric acid value, dissect observes joint and the variation of interior internal organs pipe, and as shown in table 1, table 2, the 2nd group of weight is aobvious
It writes and is lower than the 1st group and the 3rd group (P < 0.05), difference is not significant between the 1st group and the 3rd group；2nd group of uric acid level is significantly higher than the 1st
Group and the 3rd group (P < 0.05), uric acid level difference is not significant between the 1st group and the 3rd group, illustrate embodiment 1 prepare Chinese traditional medicine composition
Object can effectively prevent fowl gout.P is the probability in statistics, is statistics according to the obtained P value of significance test method,
It is generally to have statistical difference with P < 0.05, similarly hereinafter.N in table 1, table 2 represents the number of this group of random sampling, such as n=6,
It represents the group and randomly selects 6 geese, similarly hereinafter.
Note: the identical lowercase of colleague's data shoulder mark or not mark person indicate that difference is not significant (P > 0.05), different small letters
Female person indicates significant difference (P < 0.05), and different capitalization persons indicate that difference is extremely significant (P < 0.01).Following table is same.
Therapeutic test
7 age in days white feather hybrid broilers are randomly divided into 2 groups by case one, and every group 30, the 1st group of feeding protein content is 21%
Basal feed, the basal feed that the 2nd group of feeding protein content is 30%, at modeling 14 days, the 2nd group starts gout occur,
2nd group is fed after evenly mixing with Chinese medicine composition prepared by embodiment 2, based on the weight of the Chinese medicine composition
The 2% of feed relative, treatment time are 7 days, blood drawing detection serum uric acid value, as shown in table 3, table 4, at modeling the 7-14 days,
2nd group of weight starts substantially less than 1 group (P < 0.05), and serum uric acid only starts to be significantly higher than 1 group (P < 0.05), uses embodiment
Behind Chinese medicine composition 7 days of 2 preparations, two groups of weight serum uric acids illustrate Chinese medicine composition prepared by embodiment 2 without significant difference
Fowl gout can effectively be treated.
Two Anhui goose field of case shares more than 2000 of 15 age in days Southern Anhui, because protein contains in the basal feed of feeding
It measures higher (being higher than 24%) and causes gout, 50 young geese for randomly selecting morbidity are divided into 2 groups, every group 25.1 group contains protein
The Chinese medicine composition that the basal feed that amount is 16% is prepared with embodiment 2 is fed after evenly mixing, the Chinese medicine composition
Weight be the 2.0% of basic feed relative；The basal feed that 2 groups of feeding protein contents are 16%.Treatment time be 7 days, 7
1 group of state of an illness gradually improves after it, cure rate 92%；2 groups of gout symptoms obviously deteriorate, the death rate 40%.Every group is being treated respectively
20 are randomly selected after preceding and treatment, carries out the weighing of weight and the detection of uric acid.As a result it as shown in table 5, table 6, treats 7 days
Afterwards, 1 group of weight is significantly higher than 2 groups (P < 0.05), and 1 group of uric acid class value is substantially less than 2 groups (P < 0.05).Illustrate embodiment 2
The traditional Chinese medicine composition for treating significant effect of preparation.
The shared young goose 2300 of three Anhui goose field of case, occurs visceratonia and merges joint type gout, and pathogenic factor is unknown,
50 young geese for randomly selecting morbidity are grouped, and every group 25,1 group of basal feed and implementation by protein content for 16%
Chinese medicine composition prepared by example 2 is fed after evenly mixing, and the weight of the Chinese medicine composition is basic feed relative
2.0%, the basal feed that 2 groups of feeding protein contents are 16%.Treatment time is 7 days, and every group is distinguished before the treatment and treated
After randomly select 20, carry out the weighing of weight and the detection of uric acid.As a result as described in table 7, table 8, after treatment 7 days, 1 group of body
It is significantly higher than again 2 groups (P < 0.05), 1 group of uric acid level is substantially less than 2 groups (P < 0.05).Illustrate Chinese medicine group prepared by embodiment 2
It is significant to close object therapeutic effect.
Gout occurs for a collection of 25 Day-old Broiler Chickens of four Anhui chicken house of case, and 40 chickens for randomly selecting morbidity are grouped,
Every group 20,1 group by protein content be 19% basal feed and the Chinese medicine composition for preparing of embodiment 2 after evenly mixing into
Row feeding, the weight of the Chinese medicine composition are the 2.0% of basic feed relative, the base that 2 groups of feeding protein contents are 19%
Plinth feed, treatment time are 7 days.Every group is extracted 20 at pre-treatment and after treatment respectively, carries out weighing and the uric acid of weight
Detection.As a result as shown in table 9, table 10, after treatment 7 days, 1 group of weight is significantly higher than 2 groups (P < 0.05), and 1 group of uric acid class value is aobvious
It writes and is lower than 2 groups (P < 0.05).Illustrate traditional Chinese medicine composition for treating significant effect prepared by embodiment 2.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, although referring to aforementioned reality
Applying example, invention is explained in detail, for those skilled in the art, still can be to aforementioned each implementation
Technical solution documented by example is modified or equivalent replacement of some of the technical features.It is all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (7)
1. a kind of Chinese medicine composition for preventing and treating fowl gout, which is characterized in that the Chinese medicine composition includes soil according to parts by weight
1.5-2 parts of Poria cocos, 1-2 parts of sophora flower, 1-2 parts of Lygodium japonicum, 1-1.5 parts of caulis akebiae, 0.5-1 parts of the coptis, 1-2 parts of Radix Glycyrrhizae, Radix Astragali 0.5-1
Part, 0.5-1 parts of hawthorn and 0.5-1 parts of Divine Comedy.
2. a kind of Chinese medicine composition for preventing fowl gout according to claim 1, which is characterized in that the Chinese medicine composition
It according to parts by weight include 1.5 parts of smilax, 1 part of sophora flower, 1 part of Lygodium japonicum, 1 part of caulis akebiae, 0.5 part of the coptis, 1 part of Radix Glycyrrhizae, Radix Astragali
0.5 part, 0.5 part of hawthorn and 0.5 part of Divine Comedy.
3. a kind of Chinese medicine composition for treating fowl gout according to claim 1, which is characterized in that the Chinese medicine composition
It according to parts by weight include 2 parts of smilax, 2 parts of sophora flower, 2 parts of Lygodium japonicum, 1.5 parts of caulis akebiae, 1 part of the coptis, 2 parts of Radix Glycyrrhizae, Radix Astragali 1
Part, 1 part of hawthorn and 1 part of Divine Comedy.
4. a kind of Chinese medicine composition for preventing and treating fowl gout according to claim 1, which is characterized in that the Chinese medicine composition
For powder or decoction.
5. a kind of preparation method of the Chinese medicine composition of the prevention and treatment fowl gout as described in claim 2 and 3, which is characterized in that institute
The preparation method for stating powder is to crush above-mentioned each Chinese medicinal component respectively, after crossing 40-60 mesh sieve, according to claim 2 and 3
Proportion relation is uniformly mixed, and obtains powder；
The preparation method of the decoction is to crush above-mentioned Chinese medicinal component respectively, is mixed according to the proportion relation of claim 2 and 3
Coarse powder is made, is extracted using water extraction, is extracted for the first time according to coarse powder, water quality than being extracted for the ratio of 1:20
Temperature is 75 DEG C, extraction time 1.5h；Temperature is extracted than extracting for the ratio of 1:10 according to coarse powder, water quality for the second time
Degree is 75 DEG C, extraction time 1h, collects extract, cooled and filtered twice and is concentrated in vacuo to filtrate, 0.5g/ is made
The extract solution of mL, obtains decoction.
6. a kind of application method of Chinese medicine composition as described in any one of claims 1-3, which is characterized in that by the Chinese medicine
It after composition and basal feed mix, keeps fowls, the weight of the Chinese medicine composition is the 1-2% of basic feed relative.
7. a kind of application method of Chinese medicine composition according to claim 6, which is characterized in that the basal feed is 1-
21 age in days gosling feeds or 1-20 Day-old Broiler Chickens feed or 21-48 Day-old Broiler Chickens feed；
It if 1-21 age in days gosling feed, by weight include 36.4-46 parts of corn, 13.79-15 parts of wheat wheat-middlings, rice bran
17.06-20 parts, 7.35-14.7 parts of albumen powder, 4 parts of corn germ cake, 8-9 parts of vinasse albumen feed, 0.72 part of mountain flour, corn
3 parts and one 2.28 parts of premix of albumen powder；The premix one provides for every kilogram of feed: 140,000 IU of vitamin A, vitamin
60,000 IU of D3, vitamin E 100 IU, Vitamin K3 28mg, vitamin B1 12mg, vitamin B2 62mg, vitamin B6
18mg, vitamin B12 0.12mg, pantothenic acid 100mg, niacin 3180mg, folic acid 11.6mg, biotin 1.6mg, choline 5000mg,
Mn 900mg, Zn 1000mg, Fe 1.3g, Cu 250mg, Se 4.5mg, I 7mg, lysine 25000mg；
It if 1-20 Day-old Broiler Chickens feed, by weight include 57.06 parts of corn, 29.58 parts of dregs of beans, corn protein powder 6
Part, 3.6 parts of soybean oil, 0.27 part of lysine, 0.1 part of sodium humate, 0.1 part of montmorillonite, 1.22 parts of mountain flour, calcium monohydrogen phosphate 0.8
Part, 0.27 part of salt and 21 parts of premix；The premix two provides for every kilogram of feed: methionine 1925mg, choline
1000mg, Mold adsorbent 500mg, speed solution enzyme 500mg, threonine 1050mg, phytase 120mg, rice bran meal 29050mg；
If 21-48 Day-old Broiler Chickens feed, include by weight, 31.17-66.47 parts of corn, 20.68-50.24 parts of dregs of beans,
6-9 parts of corn protein powder, 2.7-6.1 parts of soybean oil, 0-0.66 parts of lysine, 0.1 part of sodium humate, 0.1 part of montmorillonite, mountain flour
1.22 parts, 0.8 part of calcium monohydrogen phosphate, 0.27 part of salt and 31 parts of premix；The premix three provides for every kilogram of feed: egg
Propylhomoserin 1550mg, choline 700mg, Mold adsorbent 500mg, threonine 850mg, tryptophan 100mg, pure glycine betaine 1250mg,
Phytase 120mg, rice bran meal 23050mg.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110800880A (en) * | 2019-12-05 | 2020-02-18 | 河南牧业经济学院 | Gosling premix and gosling complete feed for preventing and treating goose gout |
| CN111375028A (en) * | 2020-05-13 | 2020-07-07 | 南阳中农高盛生物工程有限公司 | Preparation and use method of compound traditional Chinese medicine oral liquid for preventing and treating gosling gout |
| CN111991486A (en) * | 2020-09-10 | 2020-11-27 | 昆明邦云饲料有限公司 | Traditional Chinese medicine additive formula for treating death of meat geese due to gout and preparation method thereof |
| CN112970966A (en) * | 2021-03-24 | 2021-06-18 | 安徽好味道饲料科技有限公司 | Functional traditional Chinese medicine fermentation additive for preventing and treating goose gout |
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| CN103550481A (en) * | 2013-11-22 | 2014-02-05 | 青岛农业大学 | Pure traditional Chinese medicine composition for treating poultry gout and preparation method thereof |
| CN106310031A (en) * | 2015-06-24 | 2017-01-11 | 陆雪 | Drug for treating chicken gout |
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| CN102669496A (en) * | 2012-06-27 | 2012-09-19 | 山东新希望六和集团有限公司 | Montmorillonite-containing 1-21-days-old broiler chicken compound feed and preparation method thereof |
| CN103550481A (en) * | 2013-11-22 | 2014-02-05 | 青岛农业大学 | Pure traditional Chinese medicine composition for treating poultry gout and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110800880A (en) * | 2019-12-05 | 2020-02-18 | 河南牧业经济学院 | Gosling premix and gosling complete feed for preventing and treating goose gout |
| CN111375028A (en) * | 2020-05-13 | 2020-07-07 | 南阳中农高盛生物工程有限公司 | Preparation and use method of compound traditional Chinese medicine oral liquid for preventing and treating gosling gout |
| CN111375028B (en) * | 2020-05-13 | 2022-03-04 | 南阳中农高盛生物工程有限公司 | Preparation and use method of compound traditional Chinese medicine oral liquid for preventing and treating gosling gout |
| CN111991486A (en) * | 2020-09-10 | 2020-11-27 | 昆明邦云饲料有限公司 | Traditional Chinese medicine additive formula for treating death of meat geese due to gout and preparation method thereof |
| CN112970966A (en) * | 2021-03-24 | 2021-06-18 | 安徽好味道饲料科技有限公司 | Functional traditional Chinese medicine fermentation additive for preventing and treating goose gout |
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