CN110090279B - Traditional Chinese medicine composition for preventing and treating avian gout and preparation and use methods thereof - Google Patents
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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Abstract
The invention belongs to the field of veterinary medicines, and particularly relates to a traditional Chinese medicine composition for preventing and treating avian gout, which comprises, by weight, 1.5-2 parts of glabrous greenbrier rhizome, 1-2 parts of sophora flower, 1-2 parts of Japanese climbing fern spore, 1-1.5 parts of akebia stem, 0.5-1 part of coptis chinensis, 1-2 parts of liquorice, 0.5-1 part of astragalus membranaceus, 0.5-1 part of hawthorn and 0.5-1 part of medicated leaven. The invention has the beneficial effects that: 1. the rhizoma smilacis glabrae and the flos sophorae which have good xanthine oxidase inhibition effect are selected, so that the generation of uric acid can be effectively inhibited; 2. the Chinese medicinal composition is a pure Chinese medicinal preparation, is easy to absorb, has a remarkable effect of treating the poultry gout, has reliable effect and high safety, and does not have medicament residue; 3. the traditional Chinese medicine composition is preferably in a powder form, is convenient to manufacture, store and use, and can be popularized and applied.
Description
Technical Field
The invention belongs to the field of traditional Chinese veterinary medicines, and particularly relates to a traditional Chinese medicine composition for preventing and treating avian gout and a preparation method and a use method thereof.
Background
The fowl gout is a disease that the uric acid content in blood is obviously increased due to the over-production or excretion obstacle of the fowl uric acid, and then urate is deposited on the joint capsule, the joint cartilage, the periphery of the joint, the pleuroperitoneal cavity, the surfaces of various organs and other interstitial tissues. Clinically, the disease is characterized by slow movement of sick poultries, swollen joints of legs and wings, anorexia, lameness, weakness and diarrhea. It is pathologically characterized by an increase in uric acid levels in blood; a large amount of white urate deposits are seen on the articular surface or the visceral surface during pathological anatomy. Gout can be divided into joint type gout and visceral type gout. Around the 90 s of the 20 th century, the united kingdom and the united states, etc., attributed the colony deaths of laying hens to gout. Most of poultry gout occurs in batches in China, the mortality rate is high and sometimes reaches up to 30%, and huge economic loss is brought to the breeding industry. In recent years, the incidence of the disease tends to increase, and in particular, chickens bred intensively are growing. In waterfowl, gosling gout caused by the feed of chickens and ducks with higher protein content is frequently generated, so that the poultry gout is still one of the more common poultry diseases in China up to now.
The medicines which are used for clinically treating the avian gout are allopurinol medicines for inhibiting the generation of uric acid and benzbromarone for promoting the excretion of uric acid. However, the side effects of the drugs are large, and long-term use of the drugs can cause drug dependence, thereby reducing the quality and safety of poultry meat and egg products. Xanthine Oxidase (XOD) is an important enzyme in nucleic acid metabolism in vivo, and is widely present in livers and kidneys of cows and birds, insects, and bacteria. XOD can catalyze the oxidation of xanthine and hypoxanthine to generate uric acid, and the hyperuricemia can be caused by the over-high concentration of the uric acid, so that gout is caused. Reduce the activity of xanthine oxidase in vivo and reduce the formation of uric acid. The internationally recognized xanthine oxidase inhibitors are mainly: allopurinol, purine xanthine oxidase inhibitors, non-purine xanthine oxidase inhibitors and other xanthine oxidase inhibitors. The xanthine oxidase inhibitors studied in China mainly comprise: a xanthine oxidase inhibitor in Chinese medicinal materials, a xanthine oxidase inhibitor in Chinese medicinal compound and a food source. Xanthine oxidase inhibitors are the main drugs for treating hyperuricemia and gout, and allopurinol is the most used clinically in human medicine, but the damage to the kidney is large after the drugs are used for a long time. Therefore, the development of new xanthine oxidase inhibitor drugs is urgently needed. The extracts of the rhizoma alismatis, the caulis sinomenii and the radix angelicae have stronger in-vitro XOD activity inhibition effect found by the Wangxiao plum and the like, and the extracts of the rhizoma polygoni cuspidati have the inhibition effect on the XOD found by the plum blossom and the like, thereby providing a basis for researching the XOD inhibitor. The traditional Chinese medicine has small side effect, wide source and easy acquisition and preparation, so that the search of the xanthine oxidase inhibitor from the traditional Chinese medicine for treating the avian gout becomes the key point of research of people.
At present, few methods have definite effect on the prevention and treatment of the disease, such as allopurinol treatment to reduce the production of uric acid, but the method has high cost, and on the other hand, the ammonia synthesized in the body cannot be effectively converted into uric acid, and new adverse effects can be caused. There are some compositions for preventing and treating poultry gout, but the treatment effect is not ideal or is not investigated, the uncertainty exists, the use worry is high, and the effect on waterfowls such as geese and the like is unclear. The development of the traditional Chinese medicine composition with scientific compatibility, simple and effective components and simple preparation method is a problem which needs to be solved urgently by the chicken industry.
Disclosure of Invention
In order to solve the problems, the invention aims to provide the traditional Chinese medicine composition for preventing and treating the gout of the poultry, and the traditional Chinese medicine composition is mixed with the basic feed to feed the poultry, so that the gout of the poultry can be remarkably prevented and treated.
The invention provides the following technical scheme:
a traditional Chinese medicine composition for preventing and treating avian gout comprises, by weight, 1.5-2 parts of glabrous greenbrier rhizome, 1-2 parts of sophora flower, 1-2 parts of Japanese climbing fern spore, 1-1.5 parts of akebia stem, 0.5-1 part of coptis chinensis, 1-2 parts of liquorice, 0.5-1 part of astragalus membranaceus, 0.5-1 part of hawthorn and 0.5-1 part of medicated leaven.
Preferably, 1.5 parts of glabrous greenbrier rhizome, 1 part of sophora flower, 1 part of Japanese climbing fern spore, 1 part of akebia stem, 0.5 part of coptis root, 1 part of liquorice, 0.5 part of astragalus, 0.5 part of hawthorn and 0.5 part of medicated leaven.
Preferably, 2 parts of glabrous greenbrier rhizome, 2 parts of sophora flower, 2 parts of Japanese climbing fern spore, 1.5 parts of akebia stem, 1 part of coptis root, 2 parts of liquorice, 1 part of astragalus, 1 part of hawthorn and 1 part of medicated leaven.
Preferably, the traditional Chinese medicine composition is powder or decoction.
The invention also provides a preparation method of the traditional Chinese medicine composition for preventing and treating the poultry gout, the preparation method of the powder comprises the steps of respectively crushing the traditional Chinese medicine components, sieving the traditional Chinese medicine components by a 40-60-mesh sieve, and uniformly mixing the traditional Chinese medicine components according to the proportioning relation of the claim 1 to obtain the powder;
the preparation method of the decoction comprises the steps of respectively crushing the traditional Chinese medicine components, mixing according to the proportioning relation of claim 1 to prepare coarse powder, extracting by using a water extraction method, extracting according to the mass ratio of the coarse powder to water of 1:20 at 75 ℃ for 1.5h for the first time, extracting according to the mass ratio of the coarse powder to water of 1:10 at 75 ℃ for 1h for the second time, collecting the extracts of the two times, cooling, filtering, and concentrating the filtrate in vacuum to prepare an extract solution of 0.5g/mL to prepare the decoction.
The invention also provides a use method of the traditional Chinese medicine composition for preventing and treating the poultry gout, the traditional Chinese medicine composition is uniformly mixed with the basic feed and then fed to poultry, and the weight of the traditional Chinese medicine composition is 1-2% of that of the basic feed.
Preferably, the basic feed is a feed for 1-21-day-old goslings, a feed for 1-20-day-old broilers or a feed for 21-48-day-old broilers;
if the feed is a feed for 1-21-day-old goslings, the feed comprises, by weight, 36.4-46 parts of corn, 13.79-15 parts of wheat middling, 17.06-20 parts of rice bran, 7.35-14.7 parts of protein powder, 4 parts of corn germ meal, 8-9 parts of vinasse protein feed, 0.72 part of stone powder, 3 parts of corn protein powder and 2.28 parts of premix I; the premix I is provided for each kilogram of feed: 14 ten thousand IU of vitamin A, 36 ten thousand IU of vitamin D, 100IU of vitamin E, vitamin K328 mg, 112 mg of vitamin B, 262 mg of vitamin B, 618 mg of vitamin B, 120.12mg of vitamin B, 100mg of pantothenic acid, 3180mg of nicotinic acid, 11.6mg of folic acid, 1.6mg of biotin, 5000mg of choline, 900mg of Mn, 1000mg of Zn, 1.3g of Fe, 250mg of Cu, 4.5mg of Se, 7mg of I and 25000mg of lysine;
if the feed is a feed for 1-20-day-old broiler chickens, the feed comprises, by weight, 57.06 parts of corn, 29.58 parts of soybean meal, 6 parts of corn protein powder, 3.6 parts of soybean oil, 0.27 part of lysine, 0.1 part of sodium humate, 0.1 part of montmorillonite, 1.22 parts of stone powder, 0.8 part of calcium hydrophosphate, 0.27 part of salt and 1 part of premix II; the premix II is provided for each kilogram of feed: 1925mg of methionine, 1000mg of choline, 500mg of mildew adsorbent, 500mg of fast-decomposing enzyme, 1050mg of threonine, 120mg of phytase and 29050mg of rice bran meal;
if the feed is a feed for 21-48-day-old broiler chickens, the feed comprises, by weight, 31.17-66.47 parts of corn, 20.68-50.24 parts of soybean meal, 6-9 parts of corn protein powder, 2.7-6.1 parts of soybean oil, 0-0.66 part of lysine, 0.1 part of sodium humate, 0.1 part of montmorillonite, 1.22 parts of stone powder, 0.8 part of calcium hydrophosphate, 0.27 part of salt and 1 part of premix; the third premix is provided for each kilogram of feed: 1550mg of methionine, 700mg of choline, 500mg of a mould adsorbent, 850mg of threonine, 100mg of tryptophan, 1250mg of pure betaine, 120mg of phytase and 23050mg of rice bran meal.
The invention has the beneficial effects that:
1. the invention has the following effects of raw materials:
glabrous greenbrier rhizome: nature and taste: sweet and bland, neutral. Meridian tropism: liver meridian, stomach meridian, spleen meridian. Remove toxicity, remove dampness, and benefit joints. Nature and taste: sweet and bland, neutral. The main treatment is as follows: treating syphilis, stranguria with turbid urine, spasm and pain of muscles and bones, tinea pedis, furuncle, carbuncle, lymphoid tuberculosis, spasm of limbs due to syphilis and mercury poisoning, and pain of muscles and bones.
And (3) flos sophorae: meridian tropism: liver meridian, lung meridian, heart meridian, and large intestine meridian. The functions are as follows: cool blood to stop bleeding, clear liver to improve vision. The main treatment is as follows: hematochezia, hemorrhoid with bloody discharge, bloody dysentery, hematuria, stranguria with blood, metrorrhagia, hematemesis, epistaxis, headache due to liver heat, conjunctival congestion, swelling and pain, carbuncle, swelling, sore and ulcer.
Climbing fern spore: sweet, salty and cold. Meridian tropism: bladder, small intestine channel. The functional indications are as follows: clearing away damp-heat, treating stranguria and alleviating pain, and can be used for treating heat stranguria, stranguria with sand, stranguria with stone, stranguria with blood, stranguria with chyluria and painful urethra
B, wood through: nature and taste: bitter and slightly cold. Meridian tropism: enter heart meridian, small intestine meridian and bladder meridian. The functional indications are as follows: induce diuresis to treat stranguria, clear heart fire and relieve restlessness, dredge meridians and promote lactation.
Coptis chinensis: nature and taste: bitter taste and cold nature. Meridian tropism: it enters heart, spleen, stomach, liver, gallbladder and large intestine meridians. The efficacy is as follows: clear heat and dry dampness, purge fire and remove toxicity.
Licorice root: sweet in nature and taste and mild in nature. Meridian tropism: it enters heart, lung, spleen and stomach meridians. The functional indications are as follows: invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. The functional indications are as follows: weakness of spleen and stomach, lassitude and hypodynamia, palpitation and shortness of breath, cough with profuse sputum, spasm and pain of abdomen and limbs, carbuncle and sore, and relieving toxicity and strong nature of the medicine.
Astragalus root, nature and taste: sweet and warm. Meridian tropism: it enters lung, spleen, liver and kidney meridians. The efficacy is as follows: spontaneous sweating due to exterior deficiency, night sweat due to yin deficiency, acute nephritic edema, chronic nephritic edema, spleen and kidney deficiency, yang qi deficiency, qi deficiency asthenia, pyocutaneous disease ulceration, lung qi deficiency syndrome, and qi deficiency asthenia.
Hawthorn fruit: sour and sweet in nature and slightly warm in nature. Meridian tropism: enter spleen, stomach and liver meridians. The functional indications are as follows: promoting digestion, removing blood stasis, expelling tapeworm, promoting digestion, invigorating stomach, promoting qi circulation, and removing blood stasis, and can be used for treating meat stagnation, gastric distention, dysentery abdominal pain, blood stasis amenorrhea, puerperal stagnation, heart and abdomen stabbing pain, hernia pain, and hyperlipidemia.
Medicated leaven: nature and taste: sweet, pungent and warm. Meridian tropism: it enters spleen and stomach meridians. The efficacy is as follows: strengthen spleen and stomach, promote digestion and resolve stagnation.
The traditional Chinese medicine composition for preventing and treating the poultry gout is based on the theory of traditional Chinese medicine, nature, taste, channel tropism and efficacy of traditional Chinese medicines, is used for carrying out syndrome differentiation treatment on the basis of overall view, comprises a plurality of traditional Chinese medicines such as glabrous greenbrier rhizome, sophora flower, climbing fern spore, akebiaquinata, coptis chinensis, liquorice, astragalus, hawthorn, medicated leaven and the like, and aims at promoting urination to dissolve stones, strengthening spleen and nourishing stomach. Rhizoma Smilacis Glabrae and Coptidis rhizoma have effects of eliminating dampness, removing toxic substances and benefiting articulation; flos Sophorae Immaturus cools blood and stops bleeding, clears liver and improves eyesight; spora Lygodii and caulis Akebiae induce diuresis and treat stranguria; radix astragali is effective in relieving exterior deficiency; the hawthorn and the medicated leaven can help to digest and stimulate the appetite; licorice root, radix Glycyrrhizae coordinates the effects of the other drugs in the recipe.
2. The rhizoma smilacis glabrae and the flos sophorae which have good xanthine oxidase inhibition effect are selected, and the generation of uric acid can be effectively inhibited.
3. The Chinese medicinal composition is a pure Chinese medicinal preparation, is easy to absorb, has obvious effect of preventing and treating the avian gout, has reliable effect and high safety, and does not have medicament residue.
4. The traditional Chinese medicine composition is preferably in a powder form, is convenient to manufacture, store and use, and can be popularized and applied.
5. The Chinese medicinal components of the invention have rich resources and low cost; the prepared pure Chinese medicinal feed additive for resisting gout for the poultry has strict process standard and quality standard, has good prevention and treatment effects, and can improve the growth performance of the poultry.
Drawings
FIG. 1A is a liver tissue map of a normal goose;
FIG. 1B is a liver histology of a Tongfeng goose;
FIG. 2A is a diagram of liver tissue from a normal chicken;
FIG. 2B is a liver histology of a gout chicken;
FIG. 3A is a goose gout diagram;
FIG. 3B is a goose gout diagram;
FIG. 3C is a goose gout diagram;
fig. 3D is a goose gout diagram.
Detailed Description
The present invention will be described in detail with reference to the following examples.
Example 1
A traditional Chinese medicine composition for preventing avian gout comprises, by weight, 1.5 parts of glabrous greenbrier rhizome, 1 part of sophora flower, 1 part of Japanese climbing fern spore, 1 part of akebia stem, 0.5 part of coptis chinensis, 1 part of liquorice, 0.5 part of astragalus membranaceus, 0.5 part of hawthorn and 0.5 part of medicated leaven.
Example 2
A traditional Chinese medicine composition for treating avian gout comprises, by weight, 2 parts of glabrous greenbrier rhizome, 2 parts of sophora flower, 2 parts of Japanese climbing fern spore, 1.5 parts of akebia stem, 1 part of coptis chinensis, 2 parts of liquorice, 1 part of astragalus membranaceus, 1 part of hawthorn and 1 part of medicated leaven.
Establishment of bird gout model
The invention takes the theory that the basal feed containing high protein is easy to cause the gout of the poultry as the starting point.
The method comprises the following steps of randomly dividing 90 young geese with the age of 1 day into 3 groups, wherein each group comprises 30 goslings, the 1 st group is fed with a basic feed with the protein content of 16%, the 2 nd group is fed with a basic feed with the protein content of 20%, and the 3 rd group is fed with a basic feed with the protein content of 24%. On day 14 of feeding, component 3 resulted in a goose gout model. See FIGS. 1A, 1B, 3A, 3B, 3C and 3D.
150 white feather broilers aged 7 days are averagely divided into 4 groups, each group comprises 30 chickens, the 1 st group is fed with basic feed with 21 percent of protein content, the 2 nd group is fed with basic feed with 24 percent of protein content, the 3 rd group is fed with basic feed with 27 percent of protein content, the 4 th group is fed with basic feed with 30 percent of protein content, and the 4 th group on the 14 th day of the experiment successfully establishes a gout model. See fig. 2A, 2B.
Prevention test
In case of one, 1 day old gosling is randomly divided into 3 groups, each group comprises 30 goslings, the 1 st group is fed with basic feed with protein content of 16%, the 2 nd group is fed with basic feed with protein content of 24%, the 3 rd group is fed with basic feed with protein content of 24% after being uniformly mixed with the traditional Chinese medicine composition prepared in the example 1, the weight of the traditional Chinese medicine composition is 1% of the weight of the basic feed, blood drawing is performed to detect the serum uric acid value, the joint and visceral organ change is observed through autopsy, as shown in table 1 and table 2, the body weight of the 2 nd group is obviously lower than that of the 1 st group and the 3 rd group (P is less than 0.05), and the difference between the 1 st group and the 3 rd group is not significant; the uric acid value of the group 2 is significantly higher than those of the groups 1 and 3 (P is less than 0.05), and the difference between the uric acid values of the groups 1 and 3 is not significant, so that the traditional Chinese medicine composition prepared in the example 1 can effectively prevent the avian gout. P is the probability in statistics, which is the value of P statistically obtained according to the significance test method, and is generally the statistical difference with P < 0.05, as follows. N in tables 1 and 2 represents the number of random samples in the group, for example, n is 6, which represents the group of 6 geese randomly sampled, the same applies below.
Note: the data in the same row are marked with the same lower case letters or the same non-marked letters in shoulder, and the difference is not significant (P > 0.05), the difference is significant (P < 0.05) by different lower case letters, and the difference is extremely significant (P < 0.01) by different upper case letters. The following table is the same.
Test for treatment
In case one, 7-day-old white feather broilers are randomly divided into 2 groups, each group contains 30 chickens, the 1 st group is fed with basic feed with 21% of protein content, the 2 nd group is fed with basic feed with 30% of protein content, when the model is built for 14 days, the 2 nd group begins to suffer from gout, feeding group 2 after uniformly mixing the traditional Chinese medicine composition prepared in example 2, wherein the weight of the traditional Chinese medicine composition is 2% of the weight of the basic feed, the treatment time is 7 days, blood drawing is performed to detect the serum uric acid value, as shown in tables 3 and 4, the body weight of the group 2 was significantly lower than that of the group 1 (P < 0.05) and the serum uric acid was significantly higher than that of the group 1 (P < 0.05) at the 7 th to 14 th days of the molding, and after 7 days using the Chinese medicinal composition prepared in example 2, the two groups of body weight serum uric acids have no significant difference, which indicates that the traditional Chinese medicine composition prepared in the example 2 can effectively treat the avian gout.
In case of more than 2000 Anhui western white geese with 15 days old in a certain goose farm in Anhui province, gout is caused due to high protein content (higher than 24%) in fed basic feed, and 50 goslings with diseases are randomly selected and divided into 2 groups of 25 goslings. 1, uniformly mixing a basic feed with the protein content of 16% and the traditional Chinese medicine composition prepared in the embodiment 2, and feeding the mixture, wherein the weight of the traditional Chinese medicine composition is 2.0% of that of the basic feed; group 2 were fed with a basal feed having a protein content of 16%. The treatment time is 7 days, the disease conditions of 1 group gradually improve after 7 days, and the cure rate is 92%; the gout symptoms of 2 groups worsened significantly with a mortality rate of 40%. 20 of the samples were randomly extracted before and after treatment for weighing body weight and detecting uric acid. The results are shown in tables 5 and 6, and 7 days after treatment, the body weight of group 1 was significantly higher than that of group 2 (P < 0.05), and the uric acid group value of group 1 was significantly lower than that of group 2 (P < 0.05). The treatment effect of the traditional Chinese medicine composition prepared in example 2 is remarkable.
In case of 2300 goslings in a certain goose farm of Sanan Anhui province, visceral type joint gout occurs, the cause of the gout is unknown, 50 goslings with the morbidity are randomly selected and grouped, 25 goslings are fed, 1 group of basic feeds with the protein content of 16% and the traditional Chinese medicine composition prepared in the embodiment 2 are uniformly mixed, the weight of the traditional Chinese medicine composition is 2.0% of that of the basic feeds, and 2 groups of basic feeds with the protein content of 16% are fed. The treatment time was 7 days, and 20 animals were randomly withdrawn from each group before and after the treatment, respectively, and the body weight and uric acid were measured. As shown in tables 7 and 8, the body weight of group 1 was significantly higher than that of group 2 (P < 0.05) and the uric acid level of group 1 was significantly lower than that of group 2 (P < 0.05) after 7 days of treatment. The treatment effect of the traditional Chinese medicine composition prepared in example 2 is remarkable.
In case of gout occurring in a batch of 25-day-old broilers in a chicken farm of four Anhui province, 40 randomly selected broilers are divided into 20 chickens in each group, 1 group of the broilers is fed with basic feed with protein content of 19% and the traditional Chinese medicine composition prepared in the example 2 after being uniformly mixed, the weight of the traditional Chinese medicine composition is 2.0% of that of the basic feed, and 2 groups of the broilers are fed with the basic feed with protein content of 19%, and the treatment time is 7 days. 20 of each group were withdrawn before and after treatment, respectively, and weighing of body weight and detection of uric acid were performed. The results are shown in tables 9 and 10, and 7 days after treatment, the body weight of group 1 was significantly higher than that of group 2 (P < 0.05), and the uric acid group value of group 1 was significantly lower than that of group 2 (P < 0.05). The treatment effect of the traditional Chinese medicine composition prepared in example 2 is remarkable.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (6)
1. The application of the traditional Chinese medicine composition for preventing and treating the gout of the poultry in preparing the feed is characterized in that the feed is prepared by uniformly mixing the traditional Chinese medicine composition with a basic feed, wherein the weight of the traditional Chinese medicine composition is 1-2% of that of the basic feed;
the traditional Chinese medicine composition comprises, by weight, 1.5-2 parts of glabrous greenbrier rhizome, 1-2 parts of sophora flower, 1-2 parts of Japanese climbing fern spore, 1-1.5 parts of akebia stem, 0.5-1 part of coptis chinensis, 1-2 parts of liquorice, 0.5-1 part of astragalus membranaceus, 0.5-1 part of hawthorn and 0.5-1 part of medicated leaven.
2. The application of the traditional Chinese medicine composition for preventing the avian gout in preparing the feed according to claim 1 is characterized in that the traditional Chinese medicine composition comprises, by weight, 1.5 parts of glabrous greenbrier rhizome, 1 part of sophora flower, 1 part of spora lygodii, 1 part of akebia stem, 0.5 part of coptis chinensis, 1 part of liquorice, 0.5 part of astragalus membranaceus, 0.5 part of hawthorn and 0.5 part of medicated leaven.
3. The application of the traditional Chinese medicine composition for treating avian gout in preparing the feed according to claim 1 is characterized in that the traditional Chinese medicine composition comprises, by weight, 2 parts of glabrous greenbrier rhizome, 2 parts of sophora flower, 2 parts of Japanese climbing fern spore, 1.5 parts of akebia stem, 1 part of coptis chinensis, 2 parts of liquorice, 1 part of astragalus membranaceus, 1 part of hawthorn and 1 part of medicated leaven.
4. The application of the traditional Chinese medicine composition for preventing and treating the gout of the poultry in preparing the feed according to any one of claims 1 to 3, wherein the basic feed is a feed for 1-21-day-old goslings or a feed for 1-20-day-old broilers;
if the feed is a feed for 1-21-day-old goslings, the feed comprises, by weight, 36.4-46 parts of corn, 13.79-15 parts of wheat middling, 17.06-20 parts of rice bran, 7.35-14.7 parts of protein powder, 4 parts of corn germ meal, 8-9 parts of vinasse protein feed, 0.72 part of stone powder, 3 parts of corn protein powder and 2.28 parts of premix I; the premix I is provided for each kilogram of feed: 14 ten thousand IU of vitamin A, 36 ten thousand IU of vitamin D, 100IU of vitamin E, vitamin K328 mg, 112 mg of vitamin B, 262 mg of vitamin B, 618 mg of vitamin B, 120.12mg of vitamin B, 100mg of pantothenic acid, 3180mg of nicotinic acid, 11.6mg of folic acid, 1.6mg of biotin, 5000mg of choline, 900mg of Mn, 1000mg of Zn, 1.3g of Fe, 250mg of Cu, 4.5mg of Se, 7mg of I and 25000mg of lysine;
if the feed is a feed for 1-20-day-old broiler chickens, the feed comprises, by weight, 57.06 parts of corn, 29.58 parts of soybean meal, 6 parts of corn protein powder, 3.6 parts of soybean oil, 0.27 part of lysine, 0.1 part of sodium humate, 0.1 part of montmorillonite, 1.22 parts of stone powder, 0.8 part of calcium hydrophosphate, 0.27 part of salt and 1 part of premix II; the premix II is provided for each kilogram of feed: 1925mg of methionine, 1000mg of choline, 500mg of mildew adsorbent, 500mg of fast-decomposing enzyme, 1050mg of threonine, 120mg of phytase and 29050mg of rice bran meal.
5. The application of the traditional Chinese medicine composition for preventing and treating avian gout as claimed in claim 1, wherein the traditional Chinese medicine composition is powder or decoction.
6. The application of the traditional Chinese medicine composition for preventing and treating avian gout as claimed in claim 2 or 3 in preparing feed is characterized in that the preparation method of the traditional Chinese medicine composition comprises the following steps: the preparation method of the powder comprises pulverizing the above Chinese medicinal materials respectively, sieving with 40-60 mesh sieve, and mixing according to the proportion of claim 2 or 3 to obtain powder;
the preparation method of decoction comprises pulverizing the above Chinese medicinal materials respectively, mixing according to the proportion of claim 2 or 3 to obtain coarse powder, extracting with water at 75 deg.C for 1.5 hr at a ratio of 1: 20; extracting the coarse powder and water at a mass ratio of 1:10 for the second time at 75 deg.C for 1 hr, collecting the two extracts, cooling, filtering, and vacuum concentrating the filtrate to obtain 0.5g/mL extract solution to obtain decoction.
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| CN111375028B (en) * | 2020-05-13 | 2022-03-04 | 南阳中农高盛生物工程有限公司 | Preparation and use method of compound traditional Chinese medicine oral liquid for preventing and treating gosling gout |
| CN111991486A (en) * | 2020-09-10 | 2020-11-27 | 昆明邦云饲料有限公司 | Traditional Chinese medicine additive formula for treating death of meat geese due to gout and preparation method thereof |
| CN112970966A (en) * | 2021-03-24 | 2021-06-18 | 安徽好味道饲料科技有限公司 | Functional traditional Chinese medicine fermentation additive for preventing and treating goose gout |
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| CN102669496A (en) * | 2012-06-27 | 2012-09-19 | 山东新希望六和集团有限公司 | Montmorillonite-containing 1-21-days-old broiler chicken compound feed and preparation method thereof |
| CN103550481A (en) * | 2013-11-22 | 2014-02-05 | 青岛农业大学 | Pure traditional Chinese medicine composition for treating poultry gout and preparation method thereof |
| CN106310031A (en) * | 2015-06-24 | 2017-01-11 | 陆雪 | Drug for treating chicken gout |
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| CN102669496A (en) * | 2012-06-27 | 2012-09-19 | 山东新希望六和集团有限公司 | Montmorillonite-containing 1-21-days-old broiler chicken compound feed and preparation method thereof |
| CN103550481A (en) * | 2013-11-22 | 2014-02-05 | 青岛农业大学 | Pure traditional Chinese medicine composition for treating poultry gout and preparation method thereof |
| CN106310031A (en) * | 2015-06-24 | 2017-01-11 | 陆雪 | Drug for treating chicken gout |
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