CN103977372A - Traditional Chinese medicine additive used for treating porcine epizootic diarrhea and preparing method thereof - Google Patents

Traditional Chinese medicine additive used for treating porcine epizootic diarrhea and preparing method thereof Download PDF

Info

Publication number
CN103977372A
CN103977372A CN201410199884.8A CN201410199884A CN103977372A CN 103977372 A CN103977372 A CN 103977372A CN 201410199884 A CN201410199884 A CN 201410199884A CN 103977372 A CN103977372 A CN 103977372A
Authority
CN
China
Prior art keywords
weight portions
weight portion
herba
weight
portions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410199884.8A
Other languages
Chinese (zh)
Inventor
黄河
李鑫
燕磊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shandong New Hope Liuhe Group Co Ltd
Original Assignee
Shandong New Hope Liuhe Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shandong New Hope Liuhe Group Co Ltd filed Critical Shandong New Hope Liuhe Group Co Ltd
Priority to CN201410199884.8A priority Critical patent/CN103977372A/en
Publication of CN103977372A publication Critical patent/CN103977372A/en
Pending legal-status Critical Current

Links

Abstract

The invention discloses a traditional Chinese medicine additive used for treating porcine epizootic diarrhea and a preparing method thereof. The traditional Chinese medicine additive comprises following medicine raw materials: snakegourd peel, membrane of chicken gizzard, poria cocos, caulis cistanchis, dried orange peel, gelsemium elegan, hawthorn, cirsium vlassovianum, betel nut, medicated leaven, Japanese raspberry root, malt, pyrrosia porosa, graceful jessamine herb, sulfur, zanthoxylum rhetsoides drake, red halloysite, pomegranate bark, gerbera delavayi, Chinese date, humifuse euphorbia herb, camphor, daucus caota, rhubarb root, philippine violet herb, cinnamon, fresh ginger, wild pepper spike, common fennel fruit, smilax glauco-china warb, mint oil, stellaria neglecta weihe ex bluff. et fingerh., common andrographis herb, Chinese swallowwort latex and hawksbill turtle. The additive conforms to treatment based on syndrome differentiation from entirety and has advantages of western medicines and advantages the western medicine do not have. The additive has characteristics of short cure time, short course of treatment, good curative effects, no toxic or side effects, high safety, strong targeting property, and the like. The additive increases the curative rate, reduces the death rate and boosts the immunity of pigs. Therefore, addition of the additive into basic feed can facilitate treatment of porcine epizootic diarrhea, protection of gastric mucosa and promotion of gastrointestinal motility.

Description

A kind of Chinese medicine additive that is used for the treatment of porcine epizootic diarrhea and preparation method thereof
Technical field
The present invention relates to technical field of animal, particularly a kind of Chinese medicine additive that is used for the treatment of porcine epizootic diarrhea and preparation method thereof.
Background technology
A kind of contact infectious intestinal disease that porcine epizootic diarrhea is caused by Porcine epidemic diarrhea virus, its symptom is vomiting, diarrhoea, dehydration.Clinical change is very similar to pig transmissible gastrointestinal with symptom.1971 starting in Britain, and early 1980s, primary disease occurred successively in China.
Primary disease is very similar to transmissible gastroenteritis, mostly occurs at annual December to 1～February of next year in China, also has the report of morbidity summer.The pig that can betide any age, the age is less, and symptom is heavier, and mortality rate is high.
Porcine epidemic diarrhea virus (PEDV), belongs to coronaviridae coronavirus genus.Up to the present, also do not find that this virus has different serotype.This virus is to ether, chloroform sensitivity.Virion presents many property, and tendency is circular, has cyst membrane outward.
Primary disease only betides pig, and the pig at various ages can infection morbidity.The sickness rate of suckling pig, feeder pig or fattening pig is very high, is especially injured with suckling pig the most serious, and the variation of sow sickness rate is very large, is about 15-90%.Sick pig is the main source of infection.Virus is present in intestinal villus epithelial cell and mesenteric lymph node, after discharging with feces, and contaminated environment, feedstuff, drinking-water, the vehicles and apparatus etc. and infect.Main infection approach is digestive tract.If a pig farm has many nest piglet births or wean successively, virus can constantly infect the ablactational baby pig that loses maternal antibody, makes primary disease be endemicity, and in this breeding farm, porcine epizootic diarrhea can cause the weaning period intractable diarrhea of 5-8 piglet in age in week.Primary disease is multiple is born in cold season.
Virus per os and nose directly enter small intestinal after infecting.By immunofluorescence and electron micrograph, copying of virus is to carry out in small intestinal and colon chorioepithelium cytoplasm.In other organs, do not find virus multiplication.Because first virus multiplication causes the damage of cell, then there is small cell dysfunction.Intestinal villus atrophy, has caused the long-pending minimizing of sorbent surface, and small intestinal mucosa content of alkaline phosphatase significantly reduces and then cause absorption of nutrient ingredients obstacle, and this is the main cause that causes diarrhoea, belongs to osmotic diarrhea.Severe diarrhea causes dehydration, is to cause disease pig main causes of death.
Be generally 5-8 days incubation period, artificial challenge is 8-24 hour incubation period.Main clinical symptoms is watery diarrhea, or has vomiting between diarrhoea.Vomit multiple being born in after food or sucking.The weight of symptom is variant with the size at age, and the age is less, and symptom is heavier.In one week age there is the rear 3-4 days of diarrhoea in newborn piglet, presents serious dehydration and death, and mortality rate can reach 50%, and the highest mortality rate reaches 100%.Sick temperature of pig body is normal or slightly high, and spirit is depressed, loss of appetite or absolutely useless.Wean pig, sow are often down in spirits, anorexia and persistence suffers from diarrhoea about one week, and recovers gradually normal.Retarded growth after minority pig recovers.Fattening pig is all suffered from diarrhoea after raising infection with circle, rehabilitation after a week, mortality rate 1%-3%.Adult Pig symptom is lighter, the only performance vomiting having, and severe one watery diarrhea 5-7 days can spontaneous recovery.
Chinese veterinarian thinks, porcine epizootic diarrhea is to increase with times of defecation, and excrement matter is thin, a kind of taste enteropathy card that even to gush as water sample be Clinical symptoms."Nei Jing" claims this disease for " duck is half congealed ", " lientery ", " watery diarrhea ", " watery diarrhea ", " pouring down ", " letting out afterwards " etc., and the pathogenesis of primary disease is had to more comprehensive discussion, as " Plain Questions vital QI of the body connecting with natural QI opinion a section " said: " because of in divulging a secret; be to give birth to cold and heat; being with being attacked by pathogenic wind in spring; pathogen is lingered on, is to be watery diarrhea." " Plain Questions YIN YANG classification of natural phenomena large opinion a section " say: " clear QI in the lower part of the body, raw lientery." " heavy dampness inducing diarrhea." " Plain Questions lift pain opinion a section " say: " cold visitor is in small intestinal, and it is poly-that small intestinal must not become, therefore diarrhea with abdominal pain." " Plain Questions the most pure virginity will discuss greatly a section " say: " all vomiting acid, spouting diarrhea with tenesmus, all belongs to hot." wind, cold, heat are described, wetly all can cause and have loose bowels." the bright opinion section of the lunar sun of Plain Questions " pointed out: " eating and drinking without temperance, daily life is person frequently, and the moon is subject to it ... the people the five internal organs that the moon is subject to ... lower is lientery." " Plain Questions lift pain opinion a section " point out: " anger is QI rising in reverse order, very hematemesis and lientery." illustrating that diet, daily life, feelings will are inappropriate, also can have loose bowels." Plain Questions arteries and veins is wanted a precise and tiny opinion section " said in addition: " the stomach pulse is actually swollen, and void is let out." " when Plain Questions visceral-qi method opinion a section " say: " spleen patient ... abdominal distention borborygmus of void, lientery dyspepsia." " Plain Questions is declared five gas sections " meaning: " five kinds of diseases caused by disorders of ZANG-QI ... large intestine small intestinal is for letting out." illustrate that the pathological changes internal organs of having loose bowels are relevant with taste intestine and small intestine."Nei Jing" is about the theoretical system of having loose bowels, for laying a good foundation later age.Zhang Zhongjing will be had loose bowels and dysentery is referred to as diarrhea.In " Medical Treasures of the Golden Chamber is vomitted dirty diarrhea abnormal pulse card and controlled ", primary disease is divided into stagnant and retention of damp leading to blockage of QI three types of deficiency and coldness, excess-heat, and has proposed concrete card and control.As " watery diarrhea with indigested food, cold in the interior and heat in the exterior, cold extremities after perspiration person, promote blood circulation decoction for Resuscitation master it." " diarrhea due to disorder of QI is scolded pears and strangled loose master's." point out the symptom of deficiency and coldness diarrhea, and treat when abiding by warming YANG and astringent or styptic treatment for spontaneous sweating two methods.Add: " anxious purgation, should DACHENGQI TANG for diarrhea even-forceful pulse on CUN, GUAN and CHI, feeling hardness on the epigastrium while pressing person." " diarrhea with delirium, has stercoroma also, Xiao Chengqi Tang master it." diarrhea due to excess-heat is stagnated is proposed, take to capture relieving constipation method, i.e. so-called " treating incontinent symptoms (pseudomorph) by dredging method " method.In a section, also to containing in damp, retardance mechanism of qi, must not declare freely, and aqueous vapor is also lower and cause " diarrhea accompanied with flatus person ", propose " when its urine of profit ", and with damp in point sharp intestinal, i.e. the method in so-called " anxious spending river ".Zhang Zhongjing is that the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of having loose bowels later age is laid a good foundation." Sanyin Ji Yi Bingzheng Fang Lun is had loose bowels and chatted opinion " analyzed the etiology and pathogenesis of having loose bowels all sidedly from theory on three categories of etiologic factors angle, think that not only exopathogen can cause having loose bowels, and disorder of emotion also can cause and have loose bowels.
Distinguish that to rush down lower thing stool rare clearly, or as water sample, rush down the dirty person of thing raw meat, belong to the card of cold-damp more; Loose stool, its yellow skin is brown, rushes down the smelly dirty person of thing, the card that polyphyly is damp and hot; Large loose stool dirt, aqueous-grainy diarrhea, smelly as lost ovum, mostly be the card of getting ill from overeating.Distinguish the order of importance and emergency to have loose bowels and diet is as usual for mild case; Have loose bowels and can not eat, becoming thin, or sudden attack of spouting diarrhea is immoderate, or the chronic diarrhea slippage card of can't help attaching most importance to; Acute onset, the course of disease is short is acute diarrhea; The course of disease is long, and patient's condition is delayed for chronic diarrhea.
" Jing Yue's complete work is had loose bowels " said: " all diseases of having loose bowels, how by water paddy regardless of, therefore taking diuretic as very wise move." and listed respectively diuretic prescription." Required Readings for Medical Professionals is had loose bowels " rules by men on the basis of the experience of letting out before summary, propose famous controlling and let out nine methods, be lightly ooze, ascending, refrigerant, dredge profit, Gan Huan, sour receipts, dry spleen, the kidney warming, astringent or styptic treatment for spontaneous sweating, its discussion system and comprehensively, be a great development of having loose bowels therapeutically, its practical value is also confirmed by clinical.
Western modern medicine treatment porcine epizootic diarrhea, not only side effect is larger, and Western medicine only has obvious curative effect to single disease or a class disease in the time for the treatment of, for the more disease of some diseases, curative effect may be just not too obvious, usually need out a lot of Western medicine, this just causes medicine cost high, and toxic and side effects is larger, the problems such as drug residue is larger, easy recurrence; Therefore, Chinese medicine, aspect treatment porcine epizootic diarrhea, has the advantage that Western medicine does not have, and is also more and more subject to people's favor.
Summary of the invention
Technical problem to be solved by this invention is: a kind of Chinese medicine additive that is used for the treatment of porcine epizootic diarrhea and preparation method thereof is provided; Chinese medicine additive of the present invention is from entirety; determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, not only has the advantage of Western medicine, also has advantages of that Western medicine does not have; healing time is short, short treating period, good effect; have no side effect, safe, with strong points etc. feature, improve cure rate, reduce mortality rate, can also improve the immunity of pig; therefore; Chinese medicine additive of the present invention is added in normal feedstuff, for treatment porcine epizootic diarrhea, protection gastric mucosa, promote gastrointestinal peristalsis tool to be very helpful.
In order to realize foregoing invention object, the invention provides a kind of Chinese medicine additive that is used for the treatment of porcine epizootic diarrhea, described Chinese medicine additive comprises following raw medicinal material: Pericarpium Trichosanthis, Endothelium Corneum Gigeriae Galli, Poria, Herba Cistanches, Pericarpium Citri Reticulatae, split Herba corydalis edulis quarter, Fructus Crataegi, floss back of the body Ji, Semen Arecae, Massa Medicata Fermentata, Radix Rubi parvifolii, Fructus Hordei Germinatus, Herba pyrrosiae mollis, Herba Gelsemii Elegantis, sulfur, Herba Zanthoxyli Myriacanthi, Halloysitum Rubrum, Pericarpium Granati, hook bud Herba Leibnitziae, Fructus Jujubae, Herba Euphorbiae Humifusae, Camphora, Herba dauci carotae (Fructus Dauci Carotae), Radix Et Rhizoma Rhei, Herba Violae philippicae, Cortex Cinnamomi, Rhizoma Zingiberis Recens, Fructus Piperis sarmentosi, Fructus Foeniculi, powder Rhizoma Smilacis Chinensis, Oleum menthae, match Herba stellariae mediae, Herba Andrographis, Sucus Cynanchi chinensis and Carapax Eretmochelydis.
Wherein, in Chinese medicine additive, the parts by weight of each raw medicinal material are preferably: Pericarpium Trichosanthis 10-30 weight portion, Endothelium Corneum Gigeriae Galli 15-35 weight portion, Poria 10-35 weight portion, Herba Cistanches 15-35 weight portion, Pericarpium Citri Reticulatae 10-25 weight portion, split Herba corydalis edulis 10-35 weight portion quarter, Fructus Crataegi 15-30 weight portion, floss back of the body Ji 15-35 weight portion, Semen Arecae 15-30 weight portion, Massa Medicata Fermentata 15-35 weight portion, Radix Rubi parvifolii 15-30 weight portion, Fructus Hordei Germinatus 15-35 weight portion, Herba pyrrosiae mollis 15-35 weight portion, Herba Gelsemii Elegantis 15-30 weight portion, sulfur 10-35 weight portion, Herba Zanthoxyli Myriacanthi 10-35 weight portion, Halloysitum Rubrum 15-30 weight portion, Pericarpium Granati 10-35 weight portion, hook bud Herba Leibnitziae 15-30 weight portion, Fructus Jujubae 10-35 weight portion, Herba Euphorbiae Humifusae 15-35 weight portion, Camphora 20-30 weight portion, Herba dauci carotae (Fructus Dauci Carotae) 15-30 weight portion, Radix Et Rhizoma Rhei 15-30 weight portion, Herba Violae philippicae 15-35 weight portion, Cortex Cinnamomi 20-30 weight portion, Rhizoma Zingiberis Recens 15-35 weight portion, Fructus Piperis sarmentosi 15-35 weight portion, Fructus Foeniculi 10-35 weight portion, powder Rhizoma Smilacis Chinensis 10-30 weight portion, Oleum menthae 20-30 weight portion, match Herba stellariae mediae 15-30 weight portion, Herba Andrographis 10-35 weight portion, Sucus Cynanchi chinensis 15-30 weight portion and Carapax Eretmochelydis 10-35 weight portion.
Wherein, in described Chinese medicine additive, the parts by weight of each raw medicinal material can also be preferably: Pericarpium Trichosanthis 15-30 weight portion, Endothelium Corneum Gigeriae Galli 17-35 weight portion, Poria 10-30 weight portion, Herba Cistanches 19-30 weight portion, Pericarpium Citri Reticulatae 15-25 weight portion, split Herba corydalis edulis 15-35 weight portion quarter, Fructus Crataegi 15-25 weight portion, floss back of the body Ji 15-30 weight portion, Semen Arecae 15-25 weight portion, Massa Medicata Fermentata 18-35 weight portion, Radix Rubi parvifolii 15-25 weight portion, Fructus Hordei Germinatus 19-30 weight portion, Herba pyrrosiae mollis 18-35 weight portion, Herba Gelsemii Elegantis 15-28 weight portion, sulfur 10-30 weight portion, Herba Zanthoxyli Myriacanthi 15-30 weight portion, Halloysitum Rubrum 18-30 weight portion, Pericarpium Granati 15-35 weight portion, hook bud Herba Leibnitziae 18-30 weight portion, Fructus Jujubae 10-30 weight portion, Herba Euphorbiae Humifusae 15-30 weight portion, Camphora 25-30 weight portion, Herba dauci carotae (Fructus Dauci Carotae) 18-30 weight portion, Radix Et Rhizoma Rhei 17-30 weight portion, Herba Violae philippicae 18-35 weight portion, Cortex Cinnamomi 22-30 weight portion, Rhizoma Zingiberis Recens 19-35 weight portion, Fructus Piperis sarmentosi 18-35 weight portion, Fructus Foeniculi 15-30 weight portion, powder Rhizoma Smilacis Chinensis 15-25 weight portion, Oleum menthae 20-25 weight portion, match Herba stellariae mediae 18-30 weight portion, Herba Andrographis 15-35 weight portion, Sucus Cynanchi chinensis 18-30 weight portion and Carapax Eretmochelydis 15-30 weight portion.
Wherein, in described Chinese medicine additive, the parts by weight of each raw medicinal material can also be preferably: Pericarpium Trichosanthis 18-25 weight portion, Endothelium Corneum Gigeriae Galli 19-30 weight portion, Poria 15-30 weight portion, Herba Cistanches 19-25 weight portion, Pericarpium Citri Reticulatae 17-25 weight portion, split Herba corydalis edulis 15-30 weight portion quarter, Fructus Crataegi 15-20 weight portion, floss back of the body Ji 15-25 weight portion, Semen Arecae 15-20 weight portion, Massa Medicata Fermentata 18-30 weight portion, Radix Rubi parvifolii 15-20 weight portion, Fructus Hordei Germinatus 22-30 weight portion, Herba pyrrosiae mollis 20-35 weight portion, Herba Gelsemii Elegantis 18-25 weight portion, sulfur 15-30 weight portion, Herba Zanthoxyli Myriacanthi 15-28 weight portion, Halloysitum Rubrum 22-30 weight portion, Pericarpium Granati 18-35 weight portion, hook bud Herba Leibnitziae 18-25 weight portion, Fructus Jujubae 10-25 weight portion, Herba Euphorbiae Humifusae 18-22 weight portion, Camphora 20-30 weight portion, Herba dauci carotae (Fructus Dauci Carotae) 22-30 weight portion, Radix Et Rhizoma Rhei 20-30 weight portion, Herba Violae philippicae 18-25 weight portion, Cortex Cinnamomi 25-30 weight portion, Rhizoma Zingiberis Recens 22-35 weight portion, Fructus Piperis sarmentosi 20-35 weight portion, Fructus Foeniculi 18-25 weight portion, powder Rhizoma Smilacis Chinensis 18-25 weight portion, Oleum menthae 20-22 weight portion, match Herba stellariae mediae 25-30 weight portion, Herba Andrographis 18-30 weight portion, Sucus Cynanchi chinensis 18-25 weight portion and Carapax Eretmochelydis 18-28 weight portion.
Wherein, in described Chinese medicine additive, the parts by weight of each raw medicinal material can also be preferably: Pericarpium Trichosanthis 18 weight portions, Endothelium Corneum Gigeriae Galli 20 weight portions, Poria 17 weight portions, Herba Cistanches 20 weight portions, Pericarpium Citri Reticulatae 22 weight portions, split Herba corydalis edulis 19 weight portions quarter, Fructus Crataegi 18 weight portions, floss back of the body Ji 20 weight portions, Semen Arecae 18 weight portions, Massa Medicata Fermentata 20 weight portions, Radix Rubi parvifolii 16 weight portions, Fructus Hordei Germinatus 25 weight portions, Herba pyrrosiae mollis 22 weight portions, Herba Gelsemii Elegantis 25 weight portions, sulfur 18 weight portions, Herba Zanthoxyli Myriacanthi 28 weight portions, Halloysitum Rubrum 25 weight portions, Pericarpium Granati 20 weight portions, hook bud Herba Leibnitziae 22 weight portions, Fructus Jujubae 25 weight portions, Herba Euphorbiae Humifusae 20 weight portions, Camphora 25 weight portions, Herba dauci carotae (Fructus Dauci Carotae) 28 weight portions, Radix Et Rhizoma Rhei 25 weight portions, Herba Violae philippicae 22 weight portions, Cortex Cinnamomi 28 weight portions, Rhizoma Zingiberis Recens 25 weight portions, Fructus Piperis sarmentosi 22 weight portions, Fructus Foeniculi 20 weight portions, powder Rhizoma Smilacis Chinensis 25 weight portions, Oleum menthae 22 weight portions, match Herba stellariae mediae 27 weight portions, Herba Andrographis 19 weight portions, Sucus Cynanchi chinensis 20 weight portions and Carapax Eretmochelydis 25 weight portions
Wherein, in described Chinese medicine additive, the parts by weight of each raw medicinal material can also be preferably: Pericarpium Trichosanthis 20 weight portions, Endothelium Corneum Gigeriae Galli 19 weight portions, Poria 18 weight portions, Herba Cistanches 22 weight portions, Pericarpium Citri Reticulatae 25 weight portions, split Herba corydalis edulis 28 weight portions quarter, Fructus Crataegi 17 weight portions, floss back of the body Ji 20 weight portions, Semen Arecae 20 weight portions, Massa Medicata Fermentata 25 weight portions, Radix Rubi parvifolii 18 weight portions, Fructus Hordei Germinatus 25 weight portions, Herba pyrrosiae mollis 28 weight portions, Herba Gelsemii Elegantis 20 weight portions, sulfur 25 weight portions, Herba Zanthoxyli Myriacanthi 18 weight portions, Halloysitum Rubrum 25 weight portions, Pericarpium Granati 20 weight portions, hook bud Herba Leibnitziae 25 weight portions, Fructus Jujubae 22 weight portions, Herba Euphorbiae Humifusae 19 weight portions, Camphora 20 weight portions, Herba dauci carotae (Fructus Dauci Carotae) 25 weight portions, Radix Et Rhizoma Rhei 27 weight portions, Herba Violae philippicae 20 weight portions, Cortex Cinnamomi 25 weight portions, Rhizoma Zingiberis Recens 22 weight portions, Fructus Piperis sarmentosi 25 weight portions, Fructus Foeniculi 20 weight portions, powder Rhizoma Smilacis Chinensis 25 weight portions, Oleum menthae 22 weight portions, match Herba stellariae mediae 25 weight portions, Herba Andrographis 30 weight portions, Sucus Cynanchi chinensis 18 weight portions and Carapax Eretmochelydis 20 weight portions.
Wherein, in described Chinese medicine additive, the parts by weight of each raw medicinal material can also be preferably: Pericarpium Trichosanthis 25 weight portions, Endothelium Corneum Gigeriae Galli 27 weight portions, Poria 18 weight portions, Herba Cistanches 20 weight portions, Pericarpium Citri Reticulatae 25 weight portions, split Herba corydalis edulis 25 weight portions quarter, Fructus Crataegi 18 weight portions, floss back of the body Ji 20 weight portions, Semen Arecae 19 weight portions, Massa Medicata Fermentata 26 weight portions, Radix Rubi parvifolii 17 weight portions, Fructus Hordei Germinatus 25 weight portions, Herba pyrrosiae mollis 30 weight portions, Herba Gelsemii Elegantis 25 weight portions, sulfur 28 weight portions, Herba Zanthoxyli Myriacanthi 25 weight portions, Halloysitum Rubrum 20 weight portions, Pericarpium Granati 30 weight portions, hook bud Herba Leibnitziae 20 weight portions, Fructus Jujubae 25 weight portions, Herba Euphorbiae Humifusae 20 weight portions, Camphora 25 weight portions, Herba dauci carotae (Fructus Dauci Carotae) 28 weight portions, Radix Et Rhizoma Rhei 25 weight portions, Herba Violae philippicae 20 weight portions, Cortex Cinnamomi 28 weight portions, Rhizoma Zingiberis Recens 25 weight portions, Fructus Piperis sarmentosi 35 weight portions, Fructus Foeniculi 20 weight portions, powder Rhizoma Smilacis Chinensis 25 weight portions, Oleum menthae 22 weight portions, match Herba stellariae mediae 25 weight portions, Herba Andrographis 20 weight portions, Sucus Cynanchi chinensis 25 weight portions and Carapax Eretmochelydis 28 weight portions.
For solving the problems of the technologies described above, the invention provides a kind of preparation method of the Chinese medicine additive that is used for the treatment of porcine epizootic diarrhea, described preparation method comprises the following steps: each component in described Chinese medicine additive is mixed in proportion, carrying out charcoal fries 55 minutes-60 minutes, adding with respect to mixture quality 5-6 determining alcohol is doubly 60%-80% alcoholic solution again, heating and refluxing extraction 3.0-4.0 hour, obtain the first extracting solution, filter, obtain the first filtrate, it is 60%-80% alcoholic solution that filtering residue adds with respect to its quality 3-4 determining alcohol doubly again, heating and refluxing extraction 2.0-3.0 hour, obtain the second extracting solution, filter, obtain the second filtrate, the first filtrate and the second filtrate are merged, decompression, the concentrated ethanol of removing, dry, obtain dry mastic, adopt subsequently pulverizer to pulverize, grinding particle size 290 order to 320 orders, obtain pulverous described Chinese medicine additive.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: Chinese medicine additive of the present invention is from entirety; determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs; not only there is the advantage of Western medicine; also have advantages of that Western medicine does not have; healing time is short, short treating period, good effect; have no side effect, safe, with strong points etc. feature, improve cure rate; reduce mortality rate; can also improve the immunity of pig; therefore; Chinese medicine additive of the present invention is added in normal feedstuff, for treatment porcine epizootic diarrhea, protection gastric mucosa, promote gastrointestinal peristalsis tool to be very helpful.
Detailed description of the invention
Chinese veterinarian thinks that Porcine Epidemic Diarrhea is because there being dividing of diseases caused by exogenous pathogenic factor, internal injury, and among diseases caused by exogenous pathogenic factor, damp is the most important, the spleen being adverse to dampness, external damp, the most tired resistance spleen soil, causes dysfunction of the spleen in transportation, lifting imbalance, indigestion, clear QI being mixed up with turbid QI, mix and under, formation is had loose bowels, other many exopathogen only have with damp holds concurrently mutually, can diarrhea inducing.Insufficiency of the spleen the most key in the middle of internal injury, the sick position of having loose bowels is at taste intestinal, intestine and small intestine distinguish not turbid and conduction change function can summarize by the transporting of taste and ascending the clear and descending the turbid function, taste are for having loose bowels originally, The spleen has the function to transport and transform nutrients, and water is wet, in the middle of taste again taking spleen as main, the splenopathy is insufficiency of the spleen, failing of the spleen to transport, clear QI failing to ascend, clear QI being mixed up with turbid QI, from becoming to rush down, other are inside and outside heresies such as cold, heat, wet, food, and having loose bowels due to the internal organs such as Liver and kidney, all only on the basis of the impairment of the spleen, while causing dysfunction of the spleen in transportation, just can cause and have loose bowels.Meanwhile, exopathogen and internal injury in morbidity and pathological process, often influence each other between exogenous damp and endogenous dampness, and the easiest impairment of the spleen of exogenous damp is insufficiency of the spleen easily raw wet again, reciprocal causation.The basic pathogenesis of primary disease is that insufficiency of the spleen leading to overabundance of dampness causes dysfunction of the spleen in transportation, and the intestine and small intestine development of evil in febrile disease is not normal, lifting imbalance, clear QI being mixed up with turbid QI.Insufficiency of the spleen leading to overabundance of dampness is to cause this pathogenetic key factor.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine additive that is used for the treatment of porcine epizootic diarrhea, described Chinese medicine additive comprises following raw medicinal material: Pericarpium Trichosanthis, Endothelium Corneum Gigeriae Galli, Poria, Herba Cistanches, Pericarpium Citri Reticulatae, split Herba corydalis edulis quarter, Fructus Crataegi, floss back of the body Ji, Semen Arecae, Massa Medicata Fermentata, Radix Rubi parvifolii, Fructus Hordei Germinatus, Herba pyrrosiae mollis, Herba Gelsemii Elegantis, sulfur, Herba Zanthoxyli Myriacanthi, Halloysitum Rubrum, Pericarpium Granati, hook bud Herba Leibnitziae, Fructus Jujubae, Herba Euphorbiae Humifusae, Camphora, Herba dauci carotae (Fructus Dauci Carotae), Radix Et Rhizoma Rhei, Herba Violae philippicae, Cortex Cinnamomi, Rhizoma Zingiberis Recens, Fructus Piperis sarmentosi, Fructus Foeniculi, powder Rhizoma Smilacis Chinensis, Oleum menthae, match Herba stellariae mediae, Herba Andrographis, Sucus Cynanchi chinensis and Carapax Eretmochelydis.
In described Chinese medicine additive, each component pharmacology is as follows:
Endothelium Corneum Gigeriae Galli: sweet in the mouth, cold in nature, enter spleen, stomach, small intestinal, urinary bladder channel, there are strengthening the spleen to promote digestion, arresting seminal emission to stop excessive effect, are mainly used in the distension and fullness in the abdomen of food stagnation stagnation, heating installation diarrhoea, the symptoms such as children's's infantile malnutrition, Endothelium Corneum Gigeriae Galli can promote gastric secretion, strengthens gastric peristalsis, accelerate the effects such as gastric emptying.
Poria: sweet, light, flat.GUIXIN warp, lung meridian, spleen channel, kidney channel.Function: diuretic medicine; Diuretics with the action of eliminating dampness.. " medication heart method ": " sweet with supporing yang, the panacea of dehumidifying is also for Poria, the sharp key of light energy.The flat YANG invigorating of sweet in the mouth, strengthening the spleen is relieved oedema or abdominal distension through diuresis or purgation, the inducing QI of promoting the production of body fluid." modern study shows that the interaction energy many-side that Poria has an enhancing immunity regulates immunologic function.Concoct: be soaked in water, clean, after profit, slightly steam, cut in time skin and piece or cut sheet, dry.Medication taboo: the deficiency of YIN and without damp and hot, deficiency and coldness spermatorrhea, the careful clothes of collapse of QI person.. Collective Notes to the Canon of Materia medica: " Chinese small iris makes for it.Dislike and hold back in vain.Fear Rhizoma Paridis tetraphyllae, Radix Sanguisorbae, Realgar, Radix Gentianae Macrophyllae, Carapax Et Plastrum Testudinis ", " must join book on Chinese herbal medicine ": " collapse of QI, water dry up xerostomia all forbid ".
Pericarpium Citri Reticulatae: nature and flavor hardship, pungent, temperature.Return lung, spleen channel.There is regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm.Can be used for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Therefore Pericarpium Citri Reticulatae has three major types effect, the one, lead cold-evil in the heart, two broken stagnant gas, three strengthening the spleen stomaches.This three greatly on, Main Function is row QI of the spleen and stomach.The main transmitting and distributing the fluids of taste, therefore QI of the spleen and stomach capablely can dry, spleen invigorating, reduce phlegm, therefore can say again, Pericarpium Citri Reticulatae temperature can be supported spleen, pungent can being amusing, bitter can spleen invigorating.Due to the main row QI of the spleen and stomach of Pericarpium Citri Reticulatae, taste are located in middle Jiao, and middle Jiao's gas is current, and the gas of three warmers is also sprung up thereupon.Three warmers are the organ in charge of water circulation, and current water liquid, accompanies with wetting phase; Again for hiding mansion outside mansion, the upper and heart, lung, lower and liver, kidney.So the effect of Pericarpium Citri Reticulatae can wide and all Zang Fu, spread all over whole body wet.Say from lung, pungent loose lung qi, hardship is let out lung qi, and temperatureization cold can be controlled abundant expectoration cough with asthma, and gas is stopped up food and is stopped; Say from the heart, pungent happy gas, hardship is let out heart-fire, and warm removing dampness is turbid, can control irritable feverish sensation in the chest, and the implication sound of vomiting is smelly; Say from liver, pungent loose stagnation of liver-QI, liver-fire falls in hardship, warming for eliminaring cold-damp, so its can treating the liver strongly fragrantly has heat, drink is stopped eating stagnant; Say from kidney, pungent profit kidney is dry, and it is wet that hardship is let out kidney, and gentle kidney qi, so it can control life fire deficiency, indigestion.Certainly, all explanations, all with wet relevant with spleen, so its property of medicine effect performance leeway is larger, all can be used in general activating QI to eliminate phlegm side.
Fructus Crataegi: modern study Fructus Crataegi, containing materials such as saccharide, protein, fat, vitamin C, carotene, starch, malic acid, citric acid, calcium and ferrum, has the effects such as blood fat reducing, blood pressure, heart tonifying and arrhythmia.Flavone compound vitexin in Fructus Crataegi, is the medicine that a kind of antitumaous effect is stronger, and Fructus Crataegi extract all has certain inhibitory action to cancerous cell tumor growth, propagation and infiltration metastasis." Bencao Jingshu ": Fructus Crataegi, " herbal classic " cloud: sour in the mouth, air cooling, so see its can help digestion long-pending, clots absorbing blood, gas is non-cold.Having stagnates becomes dysentery, prolonged lochia, and holding in lunar part is after-pains.It is stagnant that Fructus Crataegi can enter taste removing food stagnancy, and loose stagnated blood, therefore in harness the river dysentery and puerpera's abdomen piece pain is also.On the whole its merit is longer than dissipating fluid-retention food, strengthening the spleen and stomach, row stagnation of QI, repercussive blood, therefore children's puerpera should polyphagia it." herbal classic " is mistaken for cold, therefore the use that has the skin ulcer of washing to itch.Can prevention and cure of cardiovascular disease, there is blood vessel dilating, increase coronary flow, improve heart vigor, stimulating central nervous system system, reduce blood pressure and cholesterol, vessel softening and diuresis and sedation; There is cardiotonic, helpful to senile heart disease; Energy appetite-stimulating indigestion-relieving, offsets meat stagnation effect better; There is effect of activating blood circulation to dissipate blood stasis, contribute to remove local congestion state, traumatic injury is had to auxiliary curative effect; There is to contraction in uterus, has the effect expediting the emergence of anemia of pregnant woman just before giving birth time, and can promote uterine involution in puerperal; The substance blocking-up such as contained flavonoid and vitamin C, carotene, reduce the generation of free radical, and the immunity of enhancing body, has anti-aging, anticancer effect; In Fructus Crataegi, having relievings asthma reduces phlegm, the composition of anti-bacteria, treatment abdominal pain diarrhea.
Semen Arecae: bitter in the mouth; Pungent; Warm in nature.Return stomach; Large intestine channel.There is parasite killing, removing mass, sending down the abnormal ascending QI is capable stagnant, and row aquation is wet.Effect.Cure mainly rapid digestion of food and relieve oedema or abdominal distension through diuresis or purgation, kill intestinal volt corpse, proglottid of tapeworm; Except dampness, get round by bribery, sharp nine orifices, relieving restlessness, caking in broken abdomen; Also can control that beriberi, edema, chest pain, dysentery, abdominal distention stomachache, defecation are unfavorable, mental disorder dyspnea with rapid respiration, treat pernicious malaria, resist communicable subtropical diseases." detailed outline ": semen arecae goes out ridge table, the southern regions of the Yunnan Province, i.e. flat the and puckery person of a kind of enlarged abdomen shape in Semen Arecae, not like the good ear of the Semen Arecae long taste of point, so-called pig Semen Arecae person is.Cover the different of also local products, moderns very do not distinguish.Press Liu Xun " ridge table record " cloud, hand over, wide survivor, Semen Arecae on non-oceangoing ship, all semen arecae also, know in that and exhale as Semen Arecae, delicate and old, adopt and real eat it, stay rattan, watt room ash with food to hold up, with the communicable subtropical diseases of dispelling, receive its skin and be used as medicine, the outer black of skin, Intradermal all muscle silk as Cortex cocois radicis (Cocos nucifera L.)." Yunnan note " cloud again, large every of abdomen Semen Arecae has three, 200, when blue or green, cuts open it, with a slice betel leaf and Pulvis concha Mactrae volume with eat it, subtracts astringent taste.See this and one say, semen arecae and Semen Arecae can be general, but the slightly bad ear of force rate Semen Arecae.
Massa Medicata Fermentata: nature and flavor hardship, temperature.1. " property of medicine is examined ": " micro-bitter fragrant sweet." 2. " detailed outline is picked up any lost article from the road ": " and sweet light, delicate fragrance." enter spleen, stomach, large intestine channel.After flour, wheat bran and multi-medicament are mixed, the herbal leaven forming through fermentation.Can strengthening the spleen to promote digestion, regulating QI to expel dampness, induces sweat.The food feeling of stuffiness in chest that cures the wound, stomachache is vomited and diarrhoea, dysentery, headache due to common cold, children's hinder hungry lose full.In Massa Medicata Fermentata, there is yeast.Its composition has volatile oil, glycoside, fatty oil and vitamin B etc." Bencao Jingshu " said: " ancients use bent, the song brewing alcoholic beverages, and the sweet temperature of its abnormal smells from the patient, the special food stagnation removing of property, the stagnant gas of row taste, loose internal organs are air-cooled.Massa Medicata Fermentata is that descendant specially makes, and with hyoscine, doubles in distillers yeast ".
Fructus Hordei Germinatus: nature and flavor are sweet is flat.Return spleen, stomach warp, Liver Channel.Have promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, moves back effect of newborn relieving distension.Cure mainly food stagnation and do not disappear, abdominal distention, insufficiency of the spleen lack of appetite, newborn antiperspirant smoulders, distending pain of the breast, women's ablactation.Fructus Hordei Germinatus can be used for stagnation of QI due to depression of the liver, breast side of body feeling of distension and oppression, and liver spleen is not each, and belch is eaten less and is waited card, often and the compatibility such as Fructus Citri Sarcodactylis, to increase the effect of its soothing liver-QI stomach function regulating.
Herba Gelsemii Elegantis: Herba Gelsemii Elegantis is recklessly climing rattan of loganiaceae plant, also name Gelsemium elegans Benth., acrid in the mouth, warm in nature, herb has severe toxicity, and root, tender shoots are poisonous, and the contained poisonous alkaloids of Herb is its main toxic component.This plant is all classified drugs as in China's successive dynasties book on Chinese herbal medicine, does not generally do medicinal.Collection add guard against man-hour poisoning.But pig, sheep have very high resistance to virulence to Herba Gelsemii Elegantis, Shiqi leaf can weight gaining, anti-pestilence, and order hair pool is smooth.Compendium of Material Medica was once called: Gelsemium elegans Benth., and it is lethal that people eats its leaf person by mistake, and sheep Shiqi is large fertilizer.
Sulfur: main containing elemental sulfur S8, still there are the elements such as a small amount of calcium, ferrum, aluminum, magnesium and trace selenium, tellurium. external removing toxic substances parasite killing, treatment skin ulcer.Supporing yang benefit fire for oral administration, relieving constipation.External treatment scabies, eczema, eczema.Sexual impotence, dyspnea due to cold, frequent micturition, the constipation due to accumulation of pathogenic cold controlled for oral administration.
Halloysitum Rubrum: nature and flavor: sweet; Puckery; Acid; Temperature; Nontoxic.Effect: astringing intestine to stop diarrhea; Astringing to arrest bleeding; Removing dampness sore; Granulation promoting.Cure mainly: chronic diarrhea; Chronic dysentery; Have blood in stool; Proctoptosis; Seminal emission; Metrorrhagia; Leukorrhagia; Ulcer being unable to heal; Eczema; Traumatic hemorrhage." herbal classic " said: " main jaundice, lets out dysentery, intestinal Bleach pus and blood, and erosion of the vulva hematochezia is red white, pathogen carbuncle, cellulitis hemorrhoid malignant boil, an infections scabies scabies.”
Pericarpium Granati: sour in the mouth, puckery, warm in nature, return large intestine, kidney channel, there is relieving diarrhea with astringents, hemostasis, the effect of parasite killing, for chronic diarrhea chronic dysentery, discharging fresh blood stool, bleeding not during menses, the cards such as abdominal pain due to worm stagnation, Pericarpium Granati is inhibited to multiple pathogenic bacterias such as staphylococcus aureus, dysentery bacterium, escherichia coli, Bacillus typhi.
Fructus Jujubae: the cyclic adenosine monophosphate that Fructus Jujubae is contained is the essential composition of human body cell energy metabolism, can muscle strength reinforcing, allaying tiredness, blood vessel dilating, increase myocardial contraction, improve myocardial nutrition, and control cardiovascular system diseases is had to good effect; Chinese medicine theory thinks, Fructus Jujubae has the effects such as tonify deficiency QI invigorating, nourishing blood to tranquillize the mind, invigorating the spleen and regulating the stomach, and Fructus Jujubae has good therapeutic effect to diseases such as chronic hepatitis, liver cirrhosis, anemia, anaphylactoid purpura; Fructus Jujubae contains triterpenoid compound and cyclic adenosine monophosphate, has stronger anticancer, anti-allergic effects.Fructus Jujubae can moisten cardiopulmonary, cough-relieving, tonifying five ZANG-organs, it is deficient to control, except the intestines and stomach addiction gas, can also regulating the spleen and stomach support spleen, flat gastric qi, logical nine orifices, help 12 through etc.
Herba Euphorbiae Humifusae: being the Herba Euphorbiae Humifusae of euphorbia plant, is a kind of Chinese crude drug, gathers at summer, Qiu Erji, removes impurity, dries.Can heat-clearing and toxic substances removing; Dampness removing jaundice eliminating; Promoting blood circulation and hemostasis.Main dysentery, have loose bowels, jaundice; Hemoptysis; Spit blood; Hematuria; Have blood in stool; Metrorrhagia; Agalactia; Treating swelling and pain by traumatic injury and pathopyretic ulcer etc.
Camphora: Camphora has orifice opening, qi stagnation removing, it is foul to ward off, effect of killing parasites for relieving itching, reducing swelling and alleviating pain, cures mainly the symptoms such as scabies pruritus, traumatic pain, toothache.
Radix Et Rhizoma Rhei: can attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Removing toxic substances cures mainly: excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; Scald.Usage and dosage: for oral administration: to decoct soup, 3-12 gram; Relieving constipation by purgation, should after under, can not decoct for a long time; External: appropriate, grind into powder and dress or decoct washing, be coated with.Decocting liquid also can be used as coloclysis.Parch to black is usually used in cooling blood for hemostasis.
Cortex Cinnamomi: extremely hot in nature, acrid in the mouth, sweet, returns kidney, spleen, the heart, Liver Channel, has the fire of benefit supporing yang, let the fire back to its origin, dispersing cold for relieving pain, effect of promoting blood circulation to restore menstrual flow, for warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion collapse, stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, the cards such as heat in the upper and cold in the lower.
Rhizoma Zingiberis Recens: Rhizoma Zingiberis Recens refers to the tuber stem of ginger, calls purple Rhizoma Zingiberis Recens, Rhizoma Zingiberis Recens, fresh ginger, old ginger.Warm in nature, its distinctive " gingerol " can stimulating gastrointestinal mucosa, make gastrointestinal tract hyperemia, digestion power strengthens, and can effectively treat the abdominal distention of eating cold and cool food and too much causing, stomachache, diarrhoea, vomiting etc.Ate after Rhizoma Zingiberis Recens, people has the sensation of health heating, and this is because it can distend the blood vessels, and blood circulation is accelerated, and impels pore with it to open, and so not only the unnecessary torrid zone can be walked, and also the pathogenic bacteria in body, cold is together taken out of simultaneously.Eat cold and cool thing when health, be subject to drench with rain or in air-conditioned room, stayed long afterwards, eaten Rhizoma Zingiberis Recens and just can eliminate in time because of the cold various discomforts that remake of human body
Fructus Foeniculi: acrid in the mouth, warm in nature, there is stimulating appetite, the cold expelling of regulating the flow of vital energy, has the effect in supporing yang road, cures mainly cold in middle-JIAO, loss of appetite, nausea and vomiting, abdominal part cold type of pain; Hernia pain, painful and swollen testis; Stagnation of QI in spleen and stomach, the distension and fullness in the abdomen card such as have a pain.
Oleum menthae: Herba Menthae,, " lunar caustic grass ", for labiate " Herba Menthae " belongs to other dry herbs together, be born in by hill wetland river more popular name, and rhizome grows wild underground.The blue or green gas fragrance of Herb.Leaf, to life, is spent little lavender, and lip is spent the dark violet brown granule fruit of rear knot.Herba Menthae is one of Chinese conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, headache, conjunctival congestion, fever of the body, throat, the dental bed disease such as swell and ache.External can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.The Herba Menthae of light friend Greenhouse Fruit Picking is again the fresh vegetable on dining table.Clearly good to eat.Usually with Herba Menthae for tea, improving eyesight clears away heart-fire.
Herba Andrographis: have another name called Chun Lianqiuliu, Herba Andrographitis, Lan Helian, Radix Gentianae, golden Rhizoma et radix valerianae, Tremella aurantialba Bandoni et Zang hook, India's grass, Herba vallisneriae Spiralis etc.There are heat-clearing and toxic substances removing, antiinflammatory, reducing swelling and alleviating pain effect.Cure mainly bacillary dysentery, urinary tract infection, acute tonsillitis, enteritis, pharyngolaryngitis, pneumonia and influenza etc., external can be treated furuncle toxic swelling, trauma infection contamination etc.Herba Andrographis has eliminating inflammation and expelling toxin effect, once be applied to clinically multi-infection disease, comprise trauma infection contamination, furuncle, carbuncle, erysipelas, upper respiratory tract infection, acute and chronic tonsillitis, acute and chronic pharyngitis, acute/chronic bronchitis, acute bacillary dysentery, acute gastroenteritis, urinary tract infection, endometritis, pelvic inflammatory disease, otitis media, periodontitis etc., all have curative effect in various degree.
Pericarpium Trichosanthis: nature and flavor: sweet, cold.Gui Jing: attach to the lung and stomach meridians.Cure mainly: Qinghua heat-phlegm, promoting the circulation of QI the chest stuffiness relieving.For phlegm-heat cough, hypochondriac pain uncomfortable in chest.
Herba Cistanches: nature and flavor: sweet acid is salty, temperature.1. " herbal classic ": " sweet in the mouth, tepor." 2. " not Lu ": " acid is salty, nontoxic." 3. " book on Chinese herbal medicine just ": " sweet-salty is micro-sad, tepor." 4. " beautiful Chinese catalpa medicine solution ": " is sweet salty, and gas is flat." return through: enter kidney, large intestine channel.1. " Bencao Jingshu ": " enter kidney, percardium, the gate of vitality." 2. " book on Chinese herbal medicine is through separating ": " enters liver channel of foot-Jueyin, spleen meridian, kidney meridian." 3. " beautiful Chinese catalpa medicine solution ": " enters liver meridian, kidney meridian, the large intesting channel of Hand-Yangming." cure mainly: the kidney invigorating, benefit essence, moisturizes laxation.Control impotence in male, infertilitas feminis, leukorrhagia, metrorrhagia, chills and pain of the waist and kness, blood depletion constipation.1. " herbal classic ": " main five kinds of strain and seven kinds of impairment, invigorating middle warmer, except stem invasion by pathogenic cold burning pain, are supported the five internal organs, reinforcing YIN-essence, beneficial vital essence, gynecological mass in abdomen." 2. " not Lu ": " is except bladder pathogen, lumbago, dysentery relieving." 3. " property of medicine opinion ": " beneficial marrow, improving healthy complexion, prolongs life, and controls woman's metrorrhagia, tonifying YANG, large tonification, main also white under.It is out of fashion that " 4. " Japan hanako materia medica ": " controls male-sterilisation sun, and female is exhausted, and the moon does not produce, moistening five ZANG-organs, and longue meat, warm waist knee joint, man lets out essence, and hematuria is lost drop, leukorrhagia pain over the perineum.Well-done food of " 5. " Bencao Jingshu ": " Chinese liquor, punish-old people is the dry knot that closes just."
Split Herba corydalis edulis quarter: nature and flavor: bitter, puckery, cold.Poisonous.Cure mainly: removing toxic substances parasite killing.Cure mainly sore, leprosy dysentery head, stubborn dermatitis, venom.
Floss back of the body Ji: nature and flavor: micro-pungent, temperature.Cure mainly: dispel the wind, dehumidifying, pain relieving.For rheumatic arthritis, numb limbs and tense tendons.
Radix Rubi parvifolii: nature and flavor: sweetness and bitterness, flat.1. Guangzhou army " conventional Chinese herbal medicine handbook ": " sweetness and bitterness, cool." 2. " Fujian traditional herbal medicine ": " sweet acid, flat, nontoxic." 3. " Chongqing medical herbs ": " hardship, flat, nontoxic." cure mainly: heat-clearing and toxic substances removing, expelling wind and removing dampness, promoting blood circulation and detumescence.Cure cold high hot, laryngopharynx swelling and pain, rheumatic arthralgia, hepatitis, dysentery, oedema due to nephritis, urinary tract infection, calculus, hemoptysis, spits blood, married woman's metrorrhagia, traumatic injury, furuncle swelling toxin.1. " the SHENGCAO property of medicine is standby to be wanted ": " infusing drugs in wine strengthening bone and muscle." 2. " it is former that book on Chinese herbal medicine is asked ": " controls scrofula.Fry sustainability, open oil and put furunculosis of the buttock on the skin." 3. " Zhiwu Mingshi Tukao ": " nourishing muscle and tendon is invigorated blood circulation, and red detumescent disappears." 4. " classification medical herbs ": " controls haematemesis, irregular menstruation, traumatic injury." 5. " south of the Five Ridges gather medicinal herbs record ": " reason snakebite, flu folder color." 6. " Guizhou side's medicine among the people collection ": " antipyretic wind dispelling, dispelling the wind and dampness pathogens pain, demented.Relieving heat toxin, controls furuncle swelling toxin." 7. " Fujian traditional herbal medicine ": " tonifying YIN arresting seminal emission, treat the splenic diarrhea, only dysentery." 8. " Chinese herbal medicine is commonly used in Shanghai ": " heat-clearing and toxic substances removing, promoting blood circulation and detumescence, expelling wind and removing dampness.Cure cold high hot, laryngopharynx swelling and pain, hepatitis, hemoptysis, spits blood, oedema due to nephritis, urinary tract infection, traumatic injury, rheumatic ostalgia." 9. " middle traditional Chinese medicines are planted will ": " controls chronic hepatitis.
Herba pyrrosiae mollis: cure mainly: control stranguria, traumatic hemorrhage.1. " mount emei medicine is planted ": " and with flour, apply and control edge of a knife wound." 2. " Guangxi medicine is planted register ": " is pleasant, diuresis."
Hook bud Herba Leibnitziae: nature and flavor: pungent, micro-hardship, flat.Cure mainly: clearing away heat-damp and promoting diuresis, eliminating stagnated food and killing intestinal worms.Cure mainly dysentery, stomachache, dyspepsia, ascariasis.
Herba dauci carotae (Fructus Dauci Carotae): nature and flavor: 1. " classification medical herbs ": " nontoxic." 2. " Traditional Chinese Medicine in Sichuan will ": " is cold in nature, and bitter but slightly sweet taste is slightly poisonous." curing mainly: 1. " classification medical herbs ": " parasite killing, tobacco poisoning, detumescence, cools down, and reduces phlegm." 2. " Traditional Chinese Medicine in Sichuan will ": " controls the dry disease of women and prurigo."
Herba Zanthoxyli Myriacanthi: nature and flavor: pungent; Bitter; Temperature.Cure mainly: dispel rheumatism; Subduing swelling and detoxicating; Analgesic hemostatic.Main anemofrigid cold; Rheumatic arthralgia; Injury and bone fracture; Traumatic hemorrhage; Burn and scald; Venom.
Herba Violae philippicae: nature and flavor: sweet, cold.Cure mainly: heat clearing away, removing toxic substances, eliminating stagnation.Control furuncle, scrofula.
Fructus Piperis sarmentosi: nature and flavor: Guangzhou army " conventional Chinese herbal medicine handbook ": " micro-pungent, temperature.Cure mainly: 1. Guangzhou army " conventional Chinese herbal medicine handbook ": " warming middle-JIAO warming the stomach, wind dispelling circulation of qi promoting.Control abdominal distention stomachache, enteritis, diarrhea, inappetence, oedema due to nephritis, rheumatalgia." 2. " Guangdong Chinese herbal medicine ": " removing dampness detumescence, circulation of qi promoting is sensible, resolving phlegm and removing blood stasis.Harness the river swollen, rheumatic arthritis, colicky, cough due to wind and cold."
Powder Rhizoma Smilacis Chinensis: nature and flavor: sweet, flat.Cure mainly: heat clearing away, except pathogenic wind toxic.Root stock cures mainly metrorrhagia and leukorrhagia, stranguria with blood, scrofula, traumatic injury.Tender leaf is controlled ecthyma.
Match Herba stellariae mediae: nature and flavor: acid, flat.Cure mainly: detoxification and removing stasis, clearing away heat and promoting diuresis, stimulating milk secretion.Cure mainly hemorrhoid, swell and ache, appendicitis, pyretic stranguria, urinary tract infection.
Sucus Cynanchi chinensis: nature and flavor: root: hardship, cold.Cure mainly: root: the removing toxic substances of dispeling the wind, benefiting stomach and stopping pain.Milk: control perseverance warty vegetation.Smear for several times with milk in stem, warty vegetation is self falling layer by layer.
Carapax Eretmochelydis: nature and flavor: sweet, cold.Cure mainly: heat-clearing and toxic substances removing, relieving palpitation suppressing the hyperactive liver.Go mad for calentura, delirium, infantile convulsion, carbuncle sore tumefacting virus.
Wherein, in Chinese medicine additive, the parts by weight of each raw medicinal material are preferably: Pericarpium Trichosanthis 10-30 weight portion, Endothelium Corneum Gigeriae Galli 15-35 weight portion, Poria 10-35 weight portion, Herba Cistanches 15-35 weight portion, Pericarpium Citri Reticulatae 10-25 weight portion, split Herba corydalis edulis 10-35 weight portion quarter, Fructus Crataegi 15-30 weight portion, floss back of the body Ji 15-35 weight portion, Semen Arecae 15-30 weight portion, Massa Medicata Fermentata 15-35 weight portion, Radix Rubi parvifolii 15-30 weight portion, Fructus Hordei Germinatus 15-35 weight portion, Herba pyrrosiae mollis 15-35 weight portion, Herba Gelsemii Elegantis 15-30 weight portion, sulfur 10-35 weight portion, Herba Zanthoxyli Myriacanthi 10-35 weight portion, Halloysitum Rubrum 15-30 weight portion, Pericarpium Granati 10-35 weight portion, hook bud Herba Leibnitziae 15-30 weight portion, Fructus Jujubae 10-35 weight portion, Herba Euphorbiae Humifusae 15-35 weight portion, Camphora 20-30 weight portion, Herba dauci carotae (Fructus Dauci Carotae) 15-30 weight portion, Radix Et Rhizoma Rhei 15-30 weight portion, Herba Violae philippicae 15-35 weight portion, Cortex Cinnamomi 20-30 weight portion, Rhizoma Zingiberis Recens 15-35 weight portion, Fructus Piperis sarmentosi 15-35 weight portion, Fructus Foeniculi 10-35 weight portion, powder Rhizoma Smilacis Chinensis 10-30 weight portion, Oleum menthae 20-30 weight portion, match Herba stellariae mediae 15-30 weight portion, Herba Andrographis 10-35 weight portion, Sucus Cynanchi chinensis 15-30 weight portion and Carapax Eretmochelydis 10-35 weight portion.
Wherein, in described Chinese medicine additive, the parts by weight of each raw medicinal material can also be preferably: Pericarpium Trichosanthis 15-30 weight portion, Endothelium Corneum Gigeriae Galli 17-35 weight portion, Poria 10-30 weight portion, Herba Cistanches 19-30 weight portion, Pericarpium Citri Reticulatae 15-25 weight portion, split Herba corydalis edulis 15-35 weight portion quarter, Fructus Crataegi 15-25 weight portion, floss back of the body Ji 15-30 weight portion, Semen Arecae 15-25 weight portion, Massa Medicata Fermentata 18-35 weight portion, Radix Rubi parvifolii 15-25 weight portion, Fructus Hordei Germinatus 19-30 weight portion, Herba pyrrosiae mollis 18-35 weight portion, Herba Gelsemii Elegantis 15-28 weight portion, sulfur 10-30 weight portion, Herba Zanthoxyli Myriacanthi 15-30 weight portion, Halloysitum Rubrum 18-30 weight portion, Pericarpium Granati 15-35 weight portion, hook bud Herba Leibnitziae 18-30 weight portion, Fructus Jujubae 10-30 weight portion, Herba Euphorbiae Humifusae 15-30 weight portion, Camphora 25-30 weight portion, Herba dauci carotae (Fructus Dauci Carotae) 18-30 weight portion, Radix Et Rhizoma Rhei 17-30 weight portion, Herba Violae philippicae 18-35 weight portion, Cortex Cinnamomi 22-30 weight portion, Rhizoma Zingiberis Recens 19-35 weight portion, Fructus Piperis sarmentosi 18-35 weight portion, Fructus Foeniculi 15-30 weight portion, powder Rhizoma Smilacis Chinensis 15-25 weight portion, Oleum menthae 20-25 weight portion, match Herba stellariae mediae 18-30 weight portion, Herba Andrographis 15-35 weight portion, Sucus Cynanchi chinensis 18-30 weight portion and Carapax Eretmochelydis 15-30 weight portion.
Wherein, in described Chinese medicine additive, the parts by weight of each raw medicinal material can also be preferably: Pericarpium Trichosanthis 18-25 weight portion, Endothelium Corneum Gigeriae Galli 19-30 weight portion, Poria 15-30 weight portion, Herba Cistanches 19-25 weight portion, Pericarpium Citri Reticulatae 17-25 weight portion, split Herba corydalis edulis 15-30 weight portion quarter, Fructus Crataegi 15-20 weight portion, floss back of the body Ji 15-25 weight portion, Semen Arecae 15-20 weight portion, Massa Medicata Fermentata 18-30 weight portion, Radix Rubi parvifolii 15-20 weight portion, Fructus Hordei Germinatus 22-30 weight portion, Herba pyrrosiae mollis 20-35 weight portion, Herba Gelsemii Elegantis 18-25 weight portion, sulfur 15-30 weight portion, Herba Zanthoxyli Myriacanthi 15-28 weight portion, Halloysitum Rubrum 22-30 weight portion, Pericarpium Granati 18-35 weight portion, hook bud Herba Leibnitziae 18-25 weight portion, Fructus Jujubae 10-25 weight portion, Herba Euphorbiae Humifusae 18-22 weight portion, Camphora 20-30 weight portion, Herba dauci carotae (Fructus Dauci Carotae) 22-30 weight portion, Radix Et Rhizoma Rhei 20-30 weight portion, Herba Violae philippicae 18-25 weight portion, Cortex Cinnamomi 25-30 weight portion, Rhizoma Zingiberis Recens 22-35 weight portion, Fructus Piperis sarmentosi 20-35 weight portion, Fructus Foeniculi 18-25 weight portion, powder Rhizoma Smilacis Chinensis 18-25 weight portion, Oleum menthae 20-22 weight portion, match Herba stellariae mediae 25-30 weight portion, Herba Andrographis 18-30 weight portion, Sucus Cynanchi chinensis 18-25 weight portion and Carapax Eretmochelydis 18-28 weight portion.
Wherein, in described Chinese medicine additive, the parts by weight of each raw medicinal material can also be preferably: Pericarpium Trichosanthis 18 weight portions, Endothelium Corneum Gigeriae Galli 20 weight portions, Poria 17 weight portions, Herba Cistanches 20 weight portions, Pericarpium Citri Reticulatae 22 weight portions, split Herba corydalis edulis 19 weight portions quarter, Fructus Crataegi 18 weight portions, floss back of the body Ji 20 weight portions, Semen Arecae 18 weight portions, Massa Medicata Fermentata 20 weight portions, Radix Rubi parvifolii 16 weight portions, Fructus Hordei Germinatus 25 weight portions, Herba pyrrosiae mollis 22 weight portions, Herba Gelsemii Elegantis 25 weight portions, sulfur 18 weight portions, Herba Zanthoxyli Myriacanthi 28 weight portions, Halloysitum Rubrum 25 weight portions, Pericarpium Granati 20 weight portions, hook bud Herba Leibnitziae 22 weight portions, Fructus Jujubae 25 weight portions, Herba Euphorbiae Humifusae 20 weight portions, Camphora 25 weight portions, Herba dauci carotae (Fructus Dauci Carotae) 28 weight portions, Radix Et Rhizoma Rhei 25 weight portions, Herba Violae philippicae 22 weight portions, Cortex Cinnamomi 28 weight portions, Rhizoma Zingiberis Recens 25 weight portions, Fructus Piperis sarmentosi 22 weight portions, Fructus Foeniculi 20 weight portions, powder Rhizoma Smilacis Chinensis 25 weight portions, Oleum menthae 22 weight portions, match Herba stellariae mediae 27 weight portions, Herba Andrographis 19 weight portions, Sucus Cynanchi chinensis 20 weight portions and Carapax Eretmochelydis 25 weight portions.
Wherein, in described Chinese medicine additive, the parts by weight of each raw medicinal material can also be preferably: Pericarpium Trichosanthis 20 weight portions, Endothelium Corneum Gigeriae Galli 19 weight portions, Poria 18 weight portions, Herba Cistanches 22 weight portions, Pericarpium Citri Reticulatae 25 weight portions, split Herba corydalis edulis 28 weight portions quarter, Fructus Crataegi 17 weight portions, floss back of the body Ji 20 weight portions, Semen Arecae 20 weight portions, Massa Medicata Fermentata 25 weight portions, Radix Rubi parvifolii 18 weight portions, Fructus Hordei Germinatus 25 weight portions, Herba pyrrosiae mollis 28 weight portions, Herba Gelsemii Elegantis 20 weight portions, sulfur 25 weight portions, Herba Zanthoxyli Myriacanthi 18 weight portions, Halloysitum Rubrum 25 weight portions, Pericarpium Granati 20 weight portions, hook bud Herba Leibnitziae 25 weight portions, Fructus Jujubae 22 weight portions, Herba Euphorbiae Humifusae 19 weight portions, Camphora 20 weight portions, Herba dauci carotae (Fructus Dauci Carotae) 25 weight portions, Radix Et Rhizoma Rhei 27 weight portions, Herba Violae philippicae 20 weight portions, Cortex Cinnamomi 25 weight portions, Rhizoma Zingiberis Recens 22 weight portions, Fructus Piperis sarmentosi 25 weight portions, Fructus Foeniculi 20 weight portions, powder Rhizoma Smilacis Chinensis 25 weight portions, Oleum menthae 22 weight portions, match Herba stellariae mediae 25 weight portions, Herba Andrographis 30 weight portions, Sucus Cynanchi chinensis 18 weight portions and Carapax Eretmochelydis 20 weight portions.
Wherein, in described Chinese medicine additive, the parts by weight of each raw medicinal material can also be preferably: Pericarpium Trichosanthis 25 weight portions, Endothelium Corneum Gigeriae Galli 27 weight portions, Poria 18 weight portions, Herba Cistanches 20 weight portions, Pericarpium Citri Reticulatae 25 weight portions, split Herba corydalis edulis 25 weight portions quarter, Fructus Crataegi 18 weight portions, floss back of the body Ji 20 weight portions, Semen Arecae 19 weight portions, Massa Medicata Fermentata 26 weight portions, Radix Rubi parvifolii 17 weight portions, Fructus Hordei Germinatus 25 weight portions, Herba pyrrosiae mollis 30 weight portions, Herba Gelsemii Elegantis 25 weight portions, sulfur 28 weight portions, Herba Zanthoxyli Myriacanthi 25 weight portions, Halloysitum Rubrum 20 weight portions, Pericarpium Granati 30 weight portions, hook bud Herba Leibnitziae 20 weight portions, Fructus Jujubae 25 weight portions, Herba Euphorbiae Humifusae 20 weight portions, Camphora 25 weight portions, Herba dauci carotae (Fructus Dauci Carotae) 28 weight portions, Radix Et Rhizoma Rhei 25 weight portions, Herba Violae philippicae 20 weight portions, Cortex Cinnamomi 28 weight portions, Rhizoma Zingiberis Recens 25 weight portions, Fructus Piperis sarmentosi 35 weight portions, Fructus Foeniculi 20 weight portions, powder Rhizoma Smilacis Chinensis 25 weight portions, Oleum menthae 22 weight portions, match Herba stellariae mediae 25 weight portions, Herba Andrographis 20 weight portions, Sucus Cynanchi chinensis 25 weight portions and Carapax Eretmochelydis 28 weight portions.
For solving the problems of the technologies described above, the invention provides a kind of preparation method of the Chinese medicine additive that is used for the treatment of porcine epizootic diarrhea, described preparation method comprises the following steps: each component in described Chinese medicine additive is mixed in proportion, carrying out charcoal fries 55 minutes-60 minutes, adding with respect to mixture quality 5-6 determining alcohol is doubly 60%-80% alcoholic solution again, heating and refluxing extraction 3.0-4.0 hour, obtain the first extracting solution, filter, obtain the first filtrate, it is 60%-80% alcoholic solution that filtering residue adds with respect to its quality 3-4 determining alcohol doubly again, heating and refluxing extraction 2.0-3.0 hour, obtain the second extracting solution, filter, obtain the second filtrate, the first filtrate and the second filtrate are merged, decompression, the concentrated ethanol of removing, dry, obtain dry mastic, adopt subsequently pulverizer to pulverize, grinding particle size 290 order to 320 orders, obtain pulverous described Chinese medicine additive.
  
Embodiment 1 Chinese medicine additive 1
The embodiment of the present invention provides a kind of Chinese medicine additive for the treatment of porcine epizootic diarrhea, is made up of the raw medicinal material of following parts by weight: Pericarpium Trichosanthis 18 weight portions, Endothelium Corneum Gigeriae Galli 20 weight portions, Poria 17 weight portions, Herba Cistanches 20 weight portions, Pericarpium Citri Reticulatae 22 weight portions, split Herba corydalis edulis 19 weight portions quarter, Fructus Crataegi 18 weight portions, floss back of the body Ji 20 weight portions, Semen Arecae 18 weight portions, Massa Medicata Fermentata 20 weight portions, Radix Rubi parvifolii 16 weight portions, Fructus Hordei Germinatus 25 weight portions, Herba pyrrosiae mollis 22 weight portions, Herba Gelsemii Elegantis 25 weight portions, sulfur 18 weight portions, Herba Zanthoxyli Myriacanthi 28 weight portions, Halloysitum Rubrum 25 weight portions, Pericarpium Granati 20 weight portions, hook bud Herba Leibnitziae 22 weight portions, Fructus Jujubae 25 weight portions, Herba Euphorbiae Humifusae 20 weight portions, Camphora 25 weight portions, Herba dauci carotae (Fructus Dauci Carotae) 28 weight portions, Radix Et Rhizoma Rhei 25 weight portions, Herba Violae philippicae 22 weight portions, Cortex Cinnamomi 28 weight portions, Rhizoma Zingiberis Recens 25 weight portions, Fructus Piperis sarmentosi 22 weight portions, Fructus Foeniculi 20 weight portions, powder Rhizoma Smilacis Chinensis 25 weight portions, Oleum menthae 22 weight portions, match Herba stellariae mediae 27 weight portions, Herba Andrographis 19 weight portions, Sucus Cynanchi chinensis 20 weight portions and Carapax Eretmochelydis 25 weight portions.
Chinese medicine additive makes by following preparation method: each component in described Chinese medicine additive is mixed in proportion, carrying out charcoal fries 55 minutes, adding with respect to the determining alcohol of 5 times of mixture qualities is 65% alcoholic solution again, heating and refluxing extraction 3.5 hours, obtain the first extracting solution, filter, obtain the first filtrate, it is 75% alcoholic solution that filtering residue adds with respect to the determining alcohol of 4 times of its quality again, heating and refluxing extraction 2.5 hours, obtain the second extracting solution, filter, obtain the second filtrate, the first filtrate and the second filtrate are merged, decompression, the concentrated ethanol of removing, dry, obtain dry mastic, adopt subsequently pulverizer to pulverize, grinding particle size 300 orders, obtain pulverous described Chinese medicine additive.
Embodiment 2 Chinese medicine additive 2
The embodiment of the present invention provides a kind of Chinese medicine additive for the treatment of porcine epizootic diarrhea, is made up of the raw medicinal material of following parts by weight: Pericarpium Trichosanthis 20 weight portions, Endothelium Corneum Gigeriae Galli 19 weight portions, Poria 18 weight portions, Herba Cistanches 22 weight portions, Pericarpium Citri Reticulatae 25 weight portions, split Herba corydalis edulis 28 weight portions quarter, Fructus Crataegi 17 weight portions, floss back of the body Ji 20 weight portions, Semen Arecae 20 weight portions, Massa Medicata Fermentata 25 weight portions, Radix Rubi parvifolii 18 weight portions, Fructus Hordei Germinatus 25 weight portions, Herba pyrrosiae mollis 28 weight portions, Herba Gelsemii Elegantis 20 weight portions, sulfur 25 weight portions, Herba Zanthoxyli Myriacanthi 18 weight portions, Halloysitum Rubrum 25 weight portions, Pericarpium Granati 20 weight portions, hook bud Herba Leibnitziae 25 weight portions, Fructus Jujubae 22 weight portions, Herba Euphorbiae Humifusae 19 weight portions, Camphora 20 weight portions, Herba dauci carotae (Fructus Dauci Carotae) 25 weight portions, Radix Et Rhizoma Rhei 27 weight portions, Herba Violae philippicae 20 weight portions, Cortex Cinnamomi 25 weight portions, Rhizoma Zingiberis Recens 22 weight portions, Fructus Piperis sarmentosi 25 weight portions, Fructus Foeniculi 20 weight portions, powder Rhizoma Smilacis Chinensis 25 weight portions, Oleum menthae 22 weight portions, match Herba stellariae mediae 25 weight portions, Herba Andrographis 30 weight portions, Sucus Cynanchi chinensis 18 weight portions and Carapax Eretmochelydis 20 weight portions.
Chinese medicine additive makes by following preparation method: each component in described Chinese medicine additive is mixed in proportion, carrying out charcoal fries 60 minutes, adding with respect to the determining alcohol of 6 times of mixture qualities is 80% alcoholic solution again, heating and refluxing extraction 4.0 hours, obtain the first extracting solution, filter, obtain the first filtrate, it is 80% alcoholic solution that filtering residue adds with respect to the determining alcohol of 3 times of its quality again, heating and refluxing extraction 3.0 hours, obtain the second extracting solution, filter, obtain the second filtrate, the first filtrate and the second filtrate are merged, decompression, the concentrated ethanol of removing, dry, obtain dry mastic, adopt subsequently pulverizer to pulverize, grinding particle size 320 orders, obtain pulverous described Chinese medicine additive.
Embodiment 3 Chinese medicine additive 3
The embodiment of the present invention provides a kind of Chinese medicine additive for the treatment of porcine epizootic diarrhea, is made up of the raw medicinal material of following parts by weight: Pericarpium Trichosanthis 25 weight portions, Endothelium Corneum Gigeriae Galli 27 weight portions, Poria 18 weight portions, Herba Cistanches 20 weight portions, Pericarpium Citri Reticulatae 25 weight portions, split Herba corydalis edulis 25 weight portions quarter, Fructus Crataegi 18 weight portions, floss back of the body Ji 20 weight portions, Semen Arecae 19 weight portions, Massa Medicata Fermentata 26 weight portions, Radix Rubi parvifolii 17 weight portions, Fructus Hordei Germinatus 25 weight portions, Herba pyrrosiae mollis 30 weight portions, Herba Gelsemii Elegantis 25 weight portions, sulfur 28 weight portions, Herba Zanthoxyli Myriacanthi 25 weight portions, Halloysitum Rubrum 20 weight portions, Pericarpium Granati 30 weight portions, hook bud Herba Leibnitziae 20 weight portions, Fructus Jujubae 25 weight portions, Herba Euphorbiae Humifusae 20 weight portions, Camphora 25 weight portions, Herba dauci carotae (Fructus Dauci Carotae) 28 weight portions, Radix Et Rhizoma Rhei 25 weight portions, Herba Violae philippicae 20 weight portions, Cortex Cinnamomi 28 weight portions, Rhizoma Zingiberis Recens 25 weight portions, Fructus Piperis sarmentosi 35 weight portions, Fructus Foeniculi 20 weight portions, powder Rhizoma Smilacis Chinensis 25 weight portions, Oleum menthae 22 weight portions, match Herba stellariae mediae 25 weight portions, Herba Andrographis 20 weight portions, Sucus Cynanchi chinensis 25 weight portions and Carapax Eretmochelydis 28 weight portions.
Chinese medicine additive makes by following preparation method: each component in described Chinese medicine additive is mixed in proportion, carrying out charcoal fries 55 minutes, adding with respect to the determining alcohol of 5.5 times of mixture qualities is 80% alcoholic solution again, heating and refluxing extraction 4.0 hours, obtain the first extracting solution, filter, obtain the first filtrate, it is 70% alcoholic solution that filtering residue adds with respect to the determining alcohol of 3 times of its quality again, heating and refluxing extraction 2.5 hours, obtain the second extracting solution, filter, obtain the second filtrate, the first filtrate and the second filtrate are merged, decompression, the concentrated ethanol of removing, dry, obtain dry mastic, adopt subsequently pulverizer to pulverize, grinding particle size 320 orders, obtain pulverous described Chinese medicine additive.
1, cumulative toxicity test report
Select 20 healthy mices, female, male each 10, taking the Chinese medicine additive of the embodiment of the present invention 1 as object, it is first phase that dosage designs every 7 days, each issue dosage is respectively 0.10LD50,0.20LD50,0.25LD50,0.30LD 50,0.40LD50, and the LD 50 female, male mice of this sample is 4000m part/k part BW (five dosage be 500,750,1100,1800,2400m part/k part BW).Within every 7 days, weigh once, adjust dosage, by 0.05ml/10 part BW per os gavage.After 28 days, animal occurs without death condition, off-test, and by ascending-dose, to tested material after 28 days, female, buck all occurs without death condition.Taking the Chinese medicine additive of embodiment 2 and embodiment 3 as object, carry out according to the method described above toxicity test, result is as identical in embodiment 1.
2, acute toxicity test
40 of application NIH mices, SPF level, male and female half and half, body weight 15～20g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, i.e. matched group and administration group, fasting 12 hours before experiment; Chinese medicine additive prepared by embodiments of the invention 1 is dissolved in water, (concentration is 6.75g crude drug/ml, maximum concentration) gavage, gavage volume is that 7ml/kg(is that single-dose dosage is 28.7 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 3 times, delivery time 8 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 21 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Therefore the acute toxicity of the Chinese medicine additive of the embodiment of the present invention 1 is low, clinical drug safety.Taking the Chinese medicine additive of embodiment 2 and embodiment 3 as object, carry out according to the method described above toxicity test, result is as identical in embodiment 1.
Treatment contrast test:
In May, 2010-2012 year May, there are 400 pigs that suffer from epidemic diarrhea, 400 pigs that suffer from epidemic diarrhea are divided into 4 groups at random, be respectively embodiment group 1, embodiment group 2, embodiment group 3 and western medicine group, use respectively the Chinese medicine additive 3 of Chinese medicine additive 2, the embodiment 3 of Chinese medicine additive 1, the embodiment 2 of embodiment 1 to treat and conventional medicament is treated, wherein, the dose of embodiment group 1-3 is every every day, in the feedstuff of every kilogram, sneak into 30g Chinese medicine additive, every 7 days is a course for the treatment of, treats continuously 4 courses for the treatment of; The conventional medicament of western medicine group is selected power promise cephalo+streptomycin+Radix Astragali immune peptide mixing intramuscular injection, utilizes 2 of 10 milliliters+gentamycin of 300 milliliters+vitamin C of compound sodium chloride injection, 80,000 units, and one day twice, continuous 7 days; Every 7 days is a course for the treatment of, treats continuously 4 courses for the treatment of; Blank group is not carried out any treatment.Treatment finishes rear observation three months, records cure rate and the mortality rate of each group of pig, and result is as shown in table 1.
Diagnostic techniques main points:
1, clinical examination main points: each age all can fall ill; Mostly occur in cold season, occurred frequently when change according to the season spring and autumn; Acute enteritis, vomiting, watery diarrhea; Intractable diarrhea, antibiotic therapy is invalid.
2, pathological anatomy technical essential: pathological changes is mainly at small intestinal, and enteral is full of yellow liquid; Mesentery hyperemia, mesenteric lymph node edema, intestinal villi shortens.
3, sample collecting technical essential: small intestinal is pushed, yellow feces is pushed together, both sides ligation; The amount of feces more than 3 milliliters, freezing preservation at subzero 20 DEG C, transport.
4, PCR detection technique main points: the pollution of Quality control, amplifing reagent, amplified production etc.; Note the storage temperature of sample.
5, ID Technology main points: 1. meet the feature such as clinical symptoms, pathological change, be judged to suspected case; 2. meet the feature such as clinical symptoms, pathological change, nosetiology detects positive, is judged to confirmed cases.
Clinical symptoms:
Main clinical symptoms is watery diarrhea, or has vomiting between diarrhoea.Vomit multiple being born in after food or sucking.The weight of symptom is variant with the size at age, and the age is less, and symptom is heavier.In one week age there is the rear 3-4 days of diarrhoea in newborn piglet, presents serious dehydration and death, and mortality rate can reach 50%, and the highest mortality rate reaches 100%.Sick temperature of pig body is normal or slightly high, and spirit is depressed, loss of appetite or absolutely useless.Wean pig, sow are often down in spirits, anorexia and persistence suffers from diarrhoea about one week, and recovers gradually normal.Retarded growth after minority pig recovers.Fattening pig is all suffered from diarrhoea after raising infection with circle, rehabilitation after a week, mortality rate 1%-3%.Adult Pig symptom is lighter, the only performance vomiting having, and severe one watery diarrhea 5-7 days can spontaneous recovery.
Curative effect determinate standard is as follows:
(1) recovery from illness: watery diarrhea or have vomiting, serious dehydration, spirit depressed between diarrhoea, loss of appetite or useless absolutely, the transference cure such as down in spirits, anorexia and persistence diarrhoea;
(2) effective: watery diarrhea or have vomiting, serious dehydration, spirit depressed between diarrhoea, loss of appetite or useless absolutely, the symptom such as down in spirits, anorexia and persistence diarrhoea alleviates more than 50%;
(3) effective: watery diarrhea or have vomiting, serious dehydration, spirit depressed between diarrhoea, loss of appetite or useless absolutely, the symptom such as down in spirits, anorexia and persistence diarrhoea alleviates 50%;
(4) invalid: watery diarrhea or have vomiting, serious dehydration, spirit depressed between diarrhoea, loss of appetite or useless absolutely, the symptom such as down in spirits, anorexia and persistence diarrhoea is without any improvement.
Therapeutic outcome:
The each experimental group therapeutic effect of table 1 synopsis
Data from table 1: medicine of the present invention is obviously better than western medicine group to the therapeutic effect of the pig that suffers from epidemic diarrhea, improve cure rate, reduce mortality rate.
Can find out referring to table 2, adopt Chinese medicine additive treatment porcine epizootic diarrhea of the present invention, on therapeutic effect, there is significant improvement with respect to conventional medicament; Treating significantly shortening on the course for the treatment of.
Four groups, table 2 is treated respectively after 4 courses for the treatment of recovery from illness and effective number and time comparative example (%)
Known according to the clinical statistics in above table, Chinese medicine provided by the invention has that healing time is short, short treating period, good effect, the feature such as safe, with strong points.
Clinical trial
Animal experiment adopts single factor contrast test design, get 100 3-45 age in week, body weight is 15-95 ㎏ left and right, suffer from epidemic diarrhea family pig, male and female half and half, test is managed and is prevented routinely on pig farm, compiles overbit, anthelmintic and protective inoculation in preliminary trial period.
The phase of just trying is divided into test group (test group is respectively embodiment group 1, embodiment group 2 and embodiment group 3) and matched group, 25 every group at random.Test period is 60 days, and free choice feeding during this time, freely drinks water, and carries out routinely immunity and anthelmintic.
Feed as follows:
Matched group: basal diet;
Test group:
Embodiment group 1: basal diet+1.5% medicine; Said medicine is the Chinese medicine additive 1 that the embodiment of the present invention 1 makes;
Embodiment group 2: basal diet+1.0% medicine; Said medicine is the Chinese medicine additive 2 that the embodiment of the present invention 2 makes;
Embodiment group 3: basal diet+1.8% medicine; Said medicine is the Chinese medicine additive 3 that the embodiment of the present invention 3 makes.
Test period is 60 days, prepares to record feeding capacity and the clout amount of duration of test, calculates every pig average daily ingestion amount and complete average daily ingestion amount of phase weekly; On-test and 7:30 weighs on an empty stomach morning while finishing, calculate the average daily gain of every pig; Carry out the health status record of routine work record and pig.All data adopt SPSS13.0 software kit to carry out variance analysis and Duncan ' S multiple comparisons.Result represents with mean+SD.
To the pig of embodiment group 1, embodiment group 2, embodiment group 3 and matched group, gather the empty venous blood of 10mL, get the mensuration of 2mL heparin anti-coagulating for t lymphocyte subset group (CD3, CD4, CD8) quantity, lymphocyte positive rate.The serum separating is used for measuring interleukin (IL-2), gamma interferon content.Lymphocyte positive rate adopts acid α-naphthyl acetate esterase Determination Staining.IL-2, gamma interferon content are detected by ELISA method, and IL-2, gamma interferon test kit provide by content MARKET company of the U.S..Adopt the U.S. EPICS-XL of Coulter company flow cytometer to detect the quantity of T lymphocyte subsets.
The impact of table 3 medicine on pig tetanus immunological function
Project Matched group Embodiment group 1 Embodiment group 2 Embodiment group 3
P(IL-2)(pg/ml) 4.30±1.32 5.16±1.77 4.93±1.31 5.20±1.47
P (gamma interferon) (pg/ml) 37.72±3.65 49.4±4.02 48.7±1.70 50.1±1.40
Lymphocyte positive rate (%) 57.47±3.21 60.3±4.05 61.1±1.64 62.3±1.76
CD3（％） 54.46±5.12 34.2±3.25 34.1±1.58 37.3±1.30
CD4（％） 34.18±3.17 36.2±1.44 36.4±1.13 36.8±1.45
CD8（％） 21.37±1.97 20.9±0.35 21.5±1.42 21.7±198
CD4/CD8（％） 1.59±0.009 1.73±0.002 1.69±0.003 1.69±0.005
Can find out from table 3, the pig of drug treating group is compared with matched group, and the IL-2 in serum, gamma interferon, lymphocyte positive rate, CD4, CD4/CD8 value all increase.As can be seen here, medicine of the present invention has improved CD4(T accessory cell in pig immunocyte) and CD4(T accessory cell) with CD8(T suppress cell) ratio, increase the composition such as complement, IL-2, gamma interferon of serum, improve to a certain extent innate immune activity in pig body, strengthen the immunity of pig body.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims (8)

1. one kind is used for the treatment of the Chinese medicine additive of porcine epizootic diarrhea, it is characterized in that, described Chinese medicine additive comprises following raw medicinal material: split Herba corydalis edulis, Fructus Crataegi, floss back of the body Ji, Semen Arecae, Massa Medicata Fermentata, Radix Rubi parvifolii, Fructus Hordei Germinatus, Herba pyrrosiae mollis, Herba Gelsemii Elegantis, sulfur, Herba Zanthoxyli Myriacanthi, Halloysitum Rubrum, Pericarpium Granati, hook bud Herba Leibnitziae, Fructus Jujubae, Herba Euphorbiae Humifusae, Camphora, Herba dauci carotae (Fructus Dauci Carotae), Radix Et Rhizoma Rhei, Herba Violae philippicae, Cortex Cinnamomi, Rhizoma Zingiberis Recens, Fructus Piperis sarmentosi, Fructus Foeniculi, powder Rhizoma Smilacis Chinensis, Oleum menthae, match Herba stellariae mediae, Herba Andrographis, Sucus Cynanchi chinensis and Carapax Eretmochelydis at Pericarpium Trichosanthis, Endothelium Corneum Gigeriae Galli, Poria, Herba Cistanches, Pericarpium Citri Reticulatae, quarter.
2. the Chinese medicine additive for the treatment of porcine epizootic diarrhea according to claim 1, is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: Pericarpium Trichosanthis 10-30 weight portion, Endothelium Corneum Gigeriae Galli 15-35 weight portion, Poria 10-35 weight portion, Herba Cistanches 15-35 weight portion, Pericarpium Citri Reticulatae 10-25 weight portion, split Herba corydalis edulis 10-35 weight portion quarter, Fructus Crataegi 15-30 weight portion, floss back of the body Ji 15-35 weight portion, Semen Arecae 15-30 weight portion, Massa Medicata Fermentata 15-35 weight portion, Radix Rubi parvifolii 15-30 weight portion, Fructus Hordei Germinatus 15-35 weight portion, Herba pyrrosiae mollis 15-35 weight portion, Herba Gelsemii Elegantis 15-30 weight portion, sulfur 10-35 weight portion, Herba Zanthoxyli Myriacanthi 10-35 weight portion, Halloysitum Rubrum 15-30 weight portion, Pericarpium Granati 10-35 weight portion, hook bud Herba Leibnitziae 15-30 weight portion, Fructus Jujubae 10-35 weight portion, Herba Euphorbiae Humifusae 15-35 weight portion, Camphora 20-30 weight portion, Herba dauci carotae (Fructus Dauci Carotae) 15-30 weight portion, Radix Et Rhizoma Rhei 15-30 weight portion, Herba Violae philippicae 15-35 weight portion, Cortex Cinnamomi 20-30 weight portion, Rhizoma Zingiberis Recens 15-35 weight portion, Fructus Piperis sarmentosi 15-35 weight portion, Fructus Foeniculi 10-35 weight portion, powder Rhizoma Smilacis Chinensis 10-30 weight portion, Oleum menthae 20-30 weight portion, match Herba stellariae mediae 15-30 weight portion, Herba Andrographis 10-35 weight portion, Sucus Cynanchi chinensis 15-30 weight portion and Carapax Eretmochelydis 10-35 weight portion.
3. the Chinese medicine additive for the treatment of porcine epizootic diarrhea according to claim 1 and 2, is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: Pericarpium Trichosanthis 15-30 weight portion, Endothelium Corneum Gigeriae Galli 17-35 weight portion, Poria 10-30 weight portion, Herba Cistanches 19-30 weight portion, Pericarpium Citri Reticulatae 15-25 weight portion, split Herba corydalis edulis 15-35 weight portion quarter, Fructus Crataegi 15-25 weight portion, floss back of the body Ji 15-30 weight portion, Semen Arecae 15-25 weight portion, Massa Medicata Fermentata 18-35 weight portion, Radix Rubi parvifolii 15-25 weight portion, Fructus Hordei Germinatus 19-30 weight portion, Herba pyrrosiae mollis 18-35 weight portion, Herba Gelsemii Elegantis 15-28 weight portion, sulfur 10-30 weight portion, Herba Zanthoxyli Myriacanthi 15-30 weight portion, Halloysitum Rubrum 18-30 weight portion, Pericarpium Granati 15-35 weight portion, hook bud Herba Leibnitziae 18-30 weight portion, Fructus Jujubae 10-30 weight portion, Herba Euphorbiae Humifusae 15-30 weight portion, Camphora 25-30 weight portion, Herba dauci carotae (Fructus Dauci Carotae) 18-30 weight portion, Radix Et Rhizoma Rhei 17-30 weight portion, Herba Violae philippicae 18-35 weight portion, Cortex Cinnamomi 22-30 weight portion, Rhizoma Zingiberis Recens 19-35 weight portion, Fructus Piperis sarmentosi 18-35 weight portion, Fructus Foeniculi 15-30 weight portion, powder Rhizoma Smilacis Chinensis 15-25 weight portion, Oleum menthae 20-25 weight portion, match Herba stellariae mediae 18-30 weight portion, Herba Andrographis 15-35 weight portion, Sucus Cynanchi chinensis 18-30 weight portion and Carapax Eretmochelydis 15-30 weight portion.
4. according to the Chinese medicine additive of the treatment porcine epizootic diarrhea described in claim 1-3 any one, it is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: Pericarpium Trichosanthis 18-25 weight portion, Endothelium Corneum Gigeriae Galli 19-30 weight portion, Poria 15-30 weight portion, Herba Cistanches 19-25 weight portion, Pericarpium Citri Reticulatae 17-25 weight portion, split Herba corydalis edulis 15-30 weight portion quarter, Fructus Crataegi 15-20 weight portion, floss back of the body Ji 15-25 weight portion, Semen Arecae 15-20 weight portion, Massa Medicata Fermentata 18-30 weight portion, Radix Rubi parvifolii 15-20 weight portion, Fructus Hordei Germinatus 22-30 weight portion, Herba pyrrosiae mollis 20-35 weight portion, Herba Gelsemii Elegantis 18-25 weight portion, sulfur 15-30 weight portion, Herba Zanthoxyli Myriacanthi 15-28 weight portion, Halloysitum Rubrum 22-30 weight portion, Pericarpium Granati 18-35 weight portion, hook bud Herba Leibnitziae 18-25 weight portion, Fructus Jujubae 10-25 weight portion, Herba Euphorbiae Humifusae 18-22 weight portion, Camphora 20-30 weight portion, Herba dauci carotae (Fructus Dauci Carotae) 22-30 weight portion, Radix Et Rhizoma Rhei 20-30 weight portion, Herba Violae philippicae 18-25 weight portion, Cortex Cinnamomi 25-30 weight portion, Rhizoma Zingiberis Recens 22-35 weight portion, Fructus Piperis sarmentosi 20-35 weight portion, Fructus Foeniculi 18-25 weight portion, powder Rhizoma Smilacis Chinensis 18-25 weight portion, Oleum menthae 20-22 weight portion, match Herba stellariae mediae 25-30 weight portion, Herba Andrographis 18-30 weight portion, Sucus Cynanchi chinensis 18-25 weight portion and Carapax Eretmochelydis 18-28 weight portion.
5. according to the Chinese medicine additive of the treatment porcine epizootic diarrhea described in claim 1-4 any one, it is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: Pericarpium Trichosanthis 18 weight portions, Endothelium Corneum Gigeriae Galli 20 weight portions, Poria 17 weight portions, Herba Cistanches 20 weight portions, Pericarpium Citri Reticulatae 22 weight portions, split Herba corydalis edulis 19 weight portions quarter, Fructus Crataegi 18 weight portions, floss back of the body Ji 20 weight portions, Semen Arecae 18 weight portions, Massa Medicata Fermentata 20 weight portions, Radix Rubi parvifolii 16 weight portions, Fructus Hordei Germinatus 25 weight portions, Herba pyrrosiae mollis 22 weight portions, Herba Gelsemii Elegantis 25 weight portions, sulfur 18 weight portions, Herba Zanthoxyli Myriacanthi 28 weight portions, Halloysitum Rubrum 25 weight portions, Pericarpium Granati 20 weight portions, hook bud Herba Leibnitziae 22 weight portions, Fructus Jujubae 25 weight portions, Herba Euphorbiae Humifusae 20 weight portions, Camphora 25 weight portions, Herba dauci carotae (Fructus Dauci Carotae) 28 weight portions, Radix Et Rhizoma Rhei 25 weight portions, Herba Violae philippicae 22 weight portions, Cortex Cinnamomi 28 weight portions, Rhizoma Zingiberis Recens 25 weight portions, Fructus Piperis sarmentosi 22 weight portions, Fructus Foeniculi 20 weight portions, powder Rhizoma Smilacis Chinensis 25 weight portions, Oleum menthae 22 weight portions, match Herba stellariae mediae 27 weight portions, Herba Andrographis 19 weight portions, Sucus Cynanchi chinensis 20 weight portions and Carapax Eretmochelydis 25 weight portions.
6. according to the Chinese medicine additive of the treatment porcine epizootic diarrhea described in claim 1-5 any one, it is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: Pericarpium Trichosanthis 20 weight portions, Endothelium Corneum Gigeriae Galli 19 weight portions, Poria 18 weight portions, Herba Cistanches 22 weight portions, Pericarpium Citri Reticulatae 25 weight portions, split Herba corydalis edulis 28 weight portions quarter, Fructus Crataegi 17 weight portions, floss back of the body Ji 20 weight portions, Semen Arecae 20 weight portions, Massa Medicata Fermentata 25 weight portions, Radix Rubi parvifolii 18 weight portions, Fructus Hordei Germinatus 25 weight portions, Herba pyrrosiae mollis 28 weight portions, Herba Gelsemii Elegantis 20 weight portions, sulfur 25 weight portions, Herba Zanthoxyli Myriacanthi 18 weight portions, Halloysitum Rubrum 25 weight portions, Pericarpium Granati 20 weight portions, hook bud Herba Leibnitziae 25 weight portions, Fructus Jujubae 22 weight portions, Herba Euphorbiae Humifusae 19 weight portions, Camphora 20 weight portions, Herba dauci carotae (Fructus Dauci Carotae) 25 weight portions, Radix Et Rhizoma Rhei 27 weight portions, Herba Violae philippicae 20 weight portions, Cortex Cinnamomi 25 weight portions, Rhizoma Zingiberis Recens 22 weight portions, Fructus Piperis sarmentosi 25 weight portions, Fructus Foeniculi 20 weight portions, powder Rhizoma Smilacis Chinensis 25 weight portions, Oleum menthae 22 weight portions, match Herba stellariae mediae 25 weight portions, Herba Andrographis 30 weight portions, Sucus Cynanchi chinensis 18 weight portions and Carapax Eretmochelydis 20 weight portions.
7. according to the Chinese medicine additive of the treatment porcine epizootic diarrhea described in claim 1-6 any one, it is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: Pericarpium Trichosanthis 25 weight portions, Endothelium Corneum Gigeriae Galli 27 weight portions, Poria 18 weight portions, Herba Cistanches 20 weight portions, Pericarpium Citri Reticulatae 25 weight portions, split Herba corydalis edulis 25 weight portions quarter, Fructus Crataegi 18 weight portions, floss back of the body Ji 20 weight portions, Semen Arecae 19 weight portions, Massa Medicata Fermentata 26 weight portions, Radix Rubi parvifolii 17 weight portions, Fructus Hordei Germinatus 25 weight portions, Herba pyrrosiae mollis 30 weight portions, Herba Gelsemii Elegantis 25 weight portions, sulfur 28 weight portions, Herba Zanthoxyli Myriacanthi 25 weight portions, Halloysitum Rubrum 20 weight portions, Pericarpium Granati 30 weight portions, hook bud Herba Leibnitziae 20 weight portions, Fructus Jujubae 25 weight portions, Herba Euphorbiae Humifusae 20 weight portions, Camphora 25 weight portions, Herba dauci carotae (Fructus Dauci Carotae) 28 weight portions, Radix Et Rhizoma Rhei 25 weight portions, Herba Violae philippicae 20 weight portions, Cortex Cinnamomi 28 weight portions, Rhizoma Zingiberis Recens 25 weight portions, Fructus Piperis sarmentosi 35 weight portions, Fructus Foeniculi 20 weight portions, powder Rhizoma Smilacis Chinensis 25 weight portions, Oleum menthae 22 weight portions, match Herba stellariae mediae 25 weight portions, Herba Andrographis 20 weight portions, Sucus Cynanchi chinensis 25 weight portions and Carapax Eretmochelydis 28 weight portions.
8. according to the Chinese medicine additive of the treatment porcine epizootic diarrhea described in claim 1-7 any one, it is characterized in that, described Chinese medicine additive preparation method comprises the following steps: each component in described Chinese medicine additive is mixed in proportion, carrying out charcoal fries 55 minutes-60 minutes, adding with respect to mixture quality 5-6 determining alcohol is doubly 60%-80% alcoholic solution again, heating and refluxing extraction 3.0-4.0 hour, obtain the first extracting solution, filter, obtain the first filtrate, it is 60%-80% alcoholic solution that filtering residue adds with respect to its quality 3-4 determining alcohol doubly again, heating and refluxing extraction 2.0-3.0 hour, obtain the second extracting solution, filter, obtain the second filtrate, the first filtrate and the second filtrate are merged, decompression, the concentrated ethanol of removing, dry, obtain dry mastic, adopt subsequently pulverizer to pulverize, grinding particle size 290 order to 320 orders, obtain pulverous described Chinese medicine additive.
CN201410199884.8A 2014-05-13 2014-05-13 Traditional Chinese medicine additive used for treating porcine epizootic diarrhea and preparing method thereof Pending CN103977372A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410199884.8A CN103977372A (en) 2014-05-13 2014-05-13 Traditional Chinese medicine additive used for treating porcine epizootic diarrhea and preparing method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410199884.8A CN103977372A (en) 2014-05-13 2014-05-13 Traditional Chinese medicine additive used for treating porcine epizootic diarrhea and preparing method thereof

Publications (1)

Publication Number Publication Date
CN103977372A true CN103977372A (en) 2014-08-13

Family

ID=51269699

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201410199884.8A Pending CN103977372A (en) 2014-05-13 2014-05-13 Traditional Chinese medicine additive used for treating porcine epizootic diarrhea and preparing method thereof

Country Status (1)

Country Link
CN (1) CN103977372A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104605195A (en) * 2015-01-20 2015-05-13 中国热带农业科学院热带作物品种资源研究所 Additive for feed for weaned pigs as well as preparation method and application of additive
CN104706728A (en) * 2015-03-23 2015-06-17 四川成康动物药业有限公司 Combinatorial medicament used for treating piglet intestinal infection and preparation method thereof
CN104758661A (en) * 2015-03-06 2015-07-08 钟云仙 Chinese medicinal composition for treatment of swine diarrhea
CN105941905A (en) * 2016-05-06 2016-09-21 山东新希望六和集团有限公司 Feed additive for improving pork qualities and reducing pig emission as well as preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102302658A (en) * 2011-09-14 2012-01-04 周剑峰 Traditional Chinese medicine powder for preventing porcine diarrhea
CN103230574A (en) * 2013-04-25 2013-08-07 中国农业科学院兰州畜牧与兽药研究所 Traditional Chinese medical composition for treating porcine epizootic diarrhea and application thereof
CN103830470A (en) * 2012-11-21 2014-06-04 青岛康地恩动物药业有限公司 Traditional Chinese medicine for treatment of diarrhea of pigs

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102302658A (en) * 2011-09-14 2012-01-04 周剑峰 Traditional Chinese medicine powder for preventing porcine diarrhea
CN103830470A (en) * 2012-11-21 2014-06-04 青岛康地恩动物药业有限公司 Traditional Chinese medicine for treatment of diarrhea of pigs
CN103230574A (en) * 2013-04-25 2013-08-07 中国农业科学院兰州畜牧与兽药研究所 Traditional Chinese medical composition for treating porcine epizootic diarrhea and application thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104605195A (en) * 2015-01-20 2015-05-13 中国热带农业科学院热带作物品种资源研究所 Additive for feed for weaned pigs as well as preparation method and application of additive
CN104758661A (en) * 2015-03-06 2015-07-08 钟云仙 Chinese medicinal composition for treatment of swine diarrhea
CN104706728A (en) * 2015-03-23 2015-06-17 四川成康动物药业有限公司 Combinatorial medicament used for treating piglet intestinal infection and preparation method thereof
CN105941905A (en) * 2016-05-06 2016-09-21 山东新希望六和集团有限公司 Feed additive for improving pork qualities and reducing pig emission as well as preparation method thereof

Similar Documents

Publication Publication Date Title
CN102048933B (en) Chinese medicinal composition for treating infantile diarrhea and preparation method thereof
CN101804166B (en) Traditional Chinese medicine composition for treating dermatitis and eczema of infants
CN104256168B (en) One boar functional feed and preparation method thereof
CN104012798B (en) Be used for the treatment of the feed of Gilt Uterus intimitis, Chinese medicine composition and preparation method
CN104351586A (en) Cattle mixed feed and preparation method thereof
CN104187172B (en) Functional feed for treating enterogastritis diseases of turtles and preparation method of functional feed
CN102198262A (en) Chinese medicine preparation for treating infant rotavirus enteritis and preparation method thereof
CN103536826B (en) One is treated colpitic Chinese medicine composition and preparation method thereof
CN103977372A (en) Traditional Chinese medicine additive used for treating porcine epizootic diarrhea and preparing method thereof
CN102580048B (en) Chinese medicine for losing weight and preparation method thereof
CN103721103A (en) Medicine for treating swine erysipelas and preparation method thereof
CN102846864A (en) Chinese herbal veterinary medicine for preventing and treating swine infectious atrophic rhinitis and preparation process thereof
CN102872321B (en) Chinese medicinal preparation for preventing and controlling porcine reproductive and respiratory syndrome and preparation method thereof
CN104001045A (en) Drug for treating dog pneumonia and preparation method thereof
CN103611021B (en) Be used for the treatment of medicine of Vesica sus domestica inflammation and preparation method thereof
CN105028995A (en) Mixed dog food and preparation method thereof
CN104957412A (en) Compound feed for cows, and preparation method of compound feed
CN104873926A (en) Traditional Chinese medicine preparation for treating diarrhea as well as preparation method and application of traditional Chinese medicine preparation
CN104800817A (en) Medicinal composition for treating dog rhinitis and preparation method thereof
CN104189413A (en) Medicine composition for treating enterogastritis diseases of turtles and preparation method of medicine composition
CN102805834A (en) Drug for curing gastritis and preparation method thereof
CN103007145B (en) Traditional Chinese medicine composition for treating children rotavirus enteritis and preparation method of composition
CN102091262B (en) Antidiarrheal powder
CN102805825B (en) Drug for curing cutaneous pruritus and preparation method thereof
CN105327147A (en) Medicine composition for treating swine enzootic pneumonia and preparation method thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20140813

RJ01 Rejection of invention patent application after publication