CN102988363B - Medicine for treating poultry proventriculitis and necrotic enteritis and preparation method thereof - Google Patents
Medicine for treating poultry proventriculitis and necrotic enteritis and preparation method thereof Download PDFInfo
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- CN102988363B CN102988363B CN201210467316.2A CN201210467316A CN102988363B CN 102988363 B CN102988363 B CN 102988363B CN 201210467316 A CN201210467316 A CN 201210467316A CN 102988363 B CN102988363 B CN 102988363B
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Abstract
The invention belongs to the technical field of veterinary medicines, and particularly relates to a medicine for treating poultry proventriculitis and necrotic enteritis and a preparation method of the medicine. The medicine per 100 parts by weight comprises the following components by weight: 1 to 10 parts of cimetidine, 5 to 30 parts of dimetridazole, 5 to 10 parts of amoxicillin, 1 to 10 parts of colloidal bismuth subcitrate, and the balance of auxiliary material. The medicine for treating poultry proventriculitis and necrotic enteritis, provided by the invention, is convenient for clinical use, and high in effective rate and cure rate.
Description
Technical field
The invention belongs to veterinary drug technical field, particularly a kind of medicine for the treatment of poultry proventriculitis and necrotic enteritis and preparation method thereof.
Background technology
Poultry proventriculitis is a kind of symptom being changed by many factors (comprising paathogenic factor and management factors) the glandular stomach function that combined effect causes and structure.In world's fowl diseases conference in 2007, participant expert has carried out discussing widely in view of this problem, but cause of disease is never definitely assert.Owing to can isolate virus in the chicken group of nearly all generation proventriculitis, so tentative " viral proventriculitis " by name.This disease extensively betides northeast, North China, south China each province at present.Primary disease all can occur throughout the year, but sickness rate is high while substituting with season, when You Yiqiu turns the winter loss more serious, in the northern area of China, performance is more obvious.Morbidity age in days is indefinite, just can show in the chickling of 3 ages in days, has report the kind chickens of 16 weeks also time.But morbidity age in days focuses mostly at 10-60 age in days.There is this pathogenetic report all parts of the country, but this disease has a larger limitation (i.e. morbidity focus mostly on a geographic area).The chicken group of morbidity derives from the chicken kind of same kind of chicken house or same strain mostly.
Necrotic enteritis is a kind of bacterial infectious disease being caused by clostridieum welchii (claiming again bacillus perfringens) A type or C type.This bacterium is a kind of conditionality pathogenic bacterium, and healthy chicken also carries this bacterium.Coop ventilation is bad, and ground is moist or feed to factors such as the fish flour bean cake of moldy metamorphism, all can bring out this disease.Sickness rate, mortality rate are not high, and day mortality rate is in 1% left and right.This disease mainly occurs in the chicken at 2 thoughtful 6 monthly ages, and the multiple broiler of being born in not only affects chicken fertility performance but also easily lures other sick generation into, causes more serious loss.
These two kinds of diseases have been brought massive losses to aviculture, need to work out corresponding medicine.
Summary of the invention
The object of the present invention is to provide a kind of medicine that is used for the treatment of poultry proventriculitis and necrotic enteritis and preparation method thereof.
The technical solution used in the present invention is as follows:
Treat a medicine for poultry proventriculitis and necrotic enteritis, the weight of every 100 parts of medicines consists of: cimetidine 1-10 part, and dimetridazole 5-30 part, amoxicillin 5-10 part, bismuth potassium citrate 1-10 part, surplus is adjuvant.
Described medicine is soluble powder.
In the time being prepared into soluble powder, described adjuvant is polyvinylpyrrolidone, beta-schardinger dextrin-, and one in water soluble starch or anhydrous glucose.
In adjuvant, polyvinylpyrrolidone is 5-10 weight portion, and beta-schardinger dextrin-is 10-20 weight portion, and all the other are anhydrous glucose or water soluble starch.
The present invention also provides a kind of preparation method of soluble powder for the treatment of poultry proventriculitis and necrotic enteritis, and cimetidine and amoxicillin are mixed homogeneously with polyvinylpyrrolidone, grinds 100 mesh sieves; Dimetridazole is mixed homogeneously with beta-schardinger dextrin-, ground 100 mesh sieves; By said mixture and bismuth potassium citrate mix homogeneously, finally add anhydrous glucose or water soluble starch.
Certainly, above-mentioned raw materials also can be prepared into other regular dosage forms on materia medica according to conventional method.
Pathogeny, paathogenic factor and the feature etc. that the present invention is directed to poultry proventriculitis and necrotic enteritis conduct in-depth research, and carry out reasonably combined according to the feature of said medicine.Wherein, cimetidine has the effect of gastric acid secretion inhibiting; can obviously suppress basis and night gastric acid secretion; also can suppress the gastric acid secretion being caused by stimulations such as histamine, point peptide gastrin, insulin and foods; and its acidity is reduced, the corrosive gastritis causing because of chemical stimulation is had to prevention and protective effect.Cimetidine and amoxicillin have the effect of Synergistic after share.Dimetridazole is wide spectrum antianaerobic-microbacterial drug, coccidiosis is also had to inhibitory action simultaneously.Bismuth potassium citrate can form insoluble bismuth-containing precipitation at gastric, adheres to securely on rotten to the corn face and forms protective barrier, resists gastric acid and the erosion of pepsin to mucosal surface.Polyvinylpyrrolidone (PVP) and beta-schardinger dextrin-are medicinal macromolecular carriers, not only play hydrotropy solubilization, have the effect of slow release, controlled release simultaneously.Conventional insoluble drugs is made soluble powder by dosage form, makes clinical use more convenient.
The present invention, with respect to prior art, has following advantage:
The medicine that is used for the treatment of poultry proventriculitis and necrotic enteritis provided by the invention, clinical easy to use, effective percentage and cure rate are high.
The specific embodiment
With specific embodiment, technical scheme of the present invention is described below, but protection scope of the present invention is not limited to this:
Embodiment 1
A kind of medicine that is used for the treatment of poultry proventriculitis and necrotic enteritis, this medicine of every 100g is made up of the crude drug of following quality: cimetidine 5g, dimetridazole 20g, amoxicillin 10g, bismuth potassium citrate 5g, polyvinylpyrrolidone (PVP) 10g and beta-schardinger dextrin-20g, all the other are anhydrous glucose.
Preparation method is as follows:
1, cimetidine and amoxicillin are mixed homogeneously by said ratio with polyvinylpyrrolidone (PVP), grind, cross 100 mesh sieves.
2, dimetridazole is mixed homogeneously by said ratio with beta-schardinger dextrin-, grind, cross 100 mesh sieves.
3, by the mixture of first two steps and bismuth potassium citrate mix homogeneously, add anhydrous glucose to 100g, to obtain final product.
Embodiment 2
A kind of medicine that is used for the treatment of poultry proventriculitis and necrotic enteritis, this medicine of every 100g is made up of the crude drug of following quality: cimetidine 5g, dimetridazole 10g, amoxicillin 5g, bismuth potassium citrate 5g, polyvinylpyrrolidone (PVP) 5g and beta-schardinger dextrin-10g, all the other are anhydrous glucose.
Preparation method is with embodiment 1.
Embodiment 3
A kind of medicine that is used for the treatment of poultry proventriculitis and necrotic enteritis, this medicine of every 100g is made up of the crude drug of following quality: cimetidine 5g, dimetridazole 30g, amoxicillin 10g, bismuth potassium citrate 5g, polyvinylpyrrolidone (PVP) 10g and beta-schardinger dextrin-20g, all the other are anhydrous glucose.
Preparation method is with embodiment 1.
Effect example 1
Utilize medicine prepared by embodiment 1 to carry out the treatment of chicken proventriculitis:
Place: broiler field, Shangqiu City Minquan County, Henan Province:
Incidence: 3000 817 broiler, 16 ages in days.Clinical symptoms is as follows: feed intake declines, and drinking-water declines, and drop-head, flocks together.Sick chicken spirit is depressed, and fear of cold is closed one's eyes slow-witted vertical, a part chicken symptom of shedding tears and swell; Row's white, white green, yellow green loose stool.Dissect disease chicken find: glandular stomach enlargement as " table tennis " sample, harden, glandular stomach wall thickening, the swelling of glandular stomach nipple, have as " blister " sample, serious glandular stomach thelorrhagia.Secrete digestive juices amount obviously reduces or does not secrete.
Diagnosis: in conjunction with epidemiology, clinical symptoms with cut open inspection situation, can be diagnosed as broiler proventriculitis.
Treatment: feed because 3000, this chicken farm chicken is divided into 2 hen houses, therefore, a hen house adopts embodiment 1 medicine to treat, and concrete grammar is to add this medicine 0.3g in 1L water, freely drinks water, and is used in conjunction 3 days.Another hen house adopts " ovum liver is relaxed ", and (effective ingredient is containing 20% mass content dimetridazole, Henan Xinzhenghao Bio-Engineering Co., Ltd. produces, lot number 20110903) to treat, concrete grammar is in 1L water, to add " ovum liver is relaxed " 0.3g, freely drink water, be used in conjunction 3 days.
Therapeutic outcome is as follows:
Total effective rate refers in this test group that spirit takes a turn for the better, the ratio of feed intake, the normal chicken of amount of drinking water and this group chicken quantity.
Test explanation utilizes Drug therapy broiler proventriculitis of the present invention than using dimetridazole successful, has played extraordinary therapeutic effect for treatment broiler proventriculitis.
Effect example 2
Utilize embodiment 1 medicine to carry out chicken necrotizing enterocolitis treatment:
20 240 of aa broiler chicken, from chicken farm, Yuanyang, Xinxiang City, Henan Province.Be divided at random 6 groups, 40 every group, go mouldy feedstuff 5 days of the moderate of feeding continuously.Find that following symptom appears in each group of chicken successively: spirit is depressed, close one's eyes drowsiness, loss of appetite, the thick disorderly unglazed frangibility of diarrhoea and feather.Row's black, Lycoperdon polymorphum Vitt loose stool, be mixed with blood sometimes, and part chicken can not stood, paralysis, and dipteron is clapped ground, stridulation when touch.Every group is cutd open 2 of inspections, finds small intestinal intestinal wall fragility, expansion gassy, and intestinal mucosa adheres to loose or fine and close pseudomembrane, and it is yellow or green that pseudomembrane outward appearance is.The visible ecchymosis of intestinal wall placenta percreta, some capillary ruptures form bruise.Mucosal bleeding reaches flesh layer deeply, has diffuse hemorrhage and occurs serious downright bad.
Can be judged as chicken necrotizing enterocolitis according to above symptom.
Take treatment measure as follows for each group:
| group | measure |
| blank group | continue to use the feedstuff that goes mouldy, do not use medicine, freely drink water. |
| matched group | change fresh feed, do not use medicine, freely drink water. |
| medicine low dose group | change fresh feed, in 1L drinking-water, add this medicine of 0.1g, freely drink water. |
| dosage group in medicine | change fresh feed, in 1L drinking-water, add this medicine of 0.3g, freely drink water. |
| medicine high dose group | change fresh feed, in 1L drinking-water, add this medicine of 0.5g, freely drink water. |
| medicine matched group | change fresh feed, in 1L drinking-water, add 0.3g ball bit, freely drink water. |
In medicine matched group " ball bit " for effective ingredient be the diclazuril (Henan Xinzhenghao Bio-Engineering Co., Ltd. produce, lot number 20110502) of 1% mass content.
Below treat continuously 3 days therapeutic effect of post-evaluation, result is as follows:
| Group | Dead (only) | Cure rate (%) | Effective percentage (%) |
| Blank group | 4 | --- | --- |
| Matched group | 2 | --- | --- |
| Medicine low dose group | 0 | 80 | 85 |
| Dosage group in medicine | 0 | 87.5 | 92.5 |
| Medicine high dose group | 0 | 92.5 | 95 |
| Medicine matched group | 1 | 60 | 75 |
The dead quantity of respectively organizing chicken death at duration of test that refers in table.
In table, cure rate refers to that clinical symptoms disappears completely after medication treatment, and spirit and appetite are recovered the ratio of normal chicken quantity and this group quantity;
In table, effective percentage refers to that clinical symptoms obviously alleviates after medication treatment, the chicken quantity that spirit and appetite take a turn for the better and the ratio of this group quantity.
Can find out from upper table data, the each medication group of this medicine has therapeutic effect in various degree to the chicken necrotizing enterocolitis of test, high, the middle dosage group of this medicine effective percentage is significantly higher than low dose group (0.01<P<0.05), and high, the middle dosage group of this medicine effective percentage, weightening finish without significant difference, therefore recommend this medicine to the usage and dosage of chicken to be: mixed drink, every 1L water 0.3g, is used in conjunction 3 days.
Medicinal application of the present invention effect in the time of other poultry such as duck goose is substantially suitable when for chicken.
Above-described embodiment is the preferred embodiment of the present invention, but embodiments of the present invention are not restricted to the described embodiments, and the change that other any the present invention of not deviating from does all should be equivalent substitute mode, within being included in protection scope of the present invention.
Claims (2)
1. a medicine for the treatment of poultry proventriculitis and necrotic enteritis, is characterized in that, described medicine is soluble powder, the weight of every 100 parts of medicines consists of: cimetidine 1-10 part, dimetridazole 5-30 part, amoxicillin 5-10 part, bismuth potassium citrate 1-10 part, surplus is adjuvant; In adjuvant, polyvinylpyrrolidone is 5-10 weight portion, and beta-schardinger dextrin-is 10-20 weight portion, and all the other are anhydrous glucose or water soluble starch.
2. the preparation method of the soluble powder for the treatment of poultry proventriculitis and necrotic enteritis, is characterized in that, cimetidine and amoxicillin are mixed homogeneously with polyvinylpyrrolidone, grinds 100 mesh sieves; Dimetridazole is mixed homogeneously with beta-schardinger dextrin-, ground 100 mesh sieves; By said mixture and bismuth potassium citrate mix homogeneously, finally add anhydrous glucose or water soluble starch; According to 100 parts of meters, the weight portion of above each raw material consists of: cimetidine 1-10 part, dimetridazole 5-30 part, amoxicillin 5-10 part, bismuth potassium citrate 1-10 part, polyvinylpyrrolidone 5-10 part, beta-schardinger dextrin-10-20 part, all the other are anhydrous glucose or water soluble starch.
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103690940B (en) * | 2013-12-26 | 2015-07-01 | 南阳新先锋制药有限公司 | Compound dimetridazole premix for preventing and treating poultry enterovirus syndrome |
| CN104323004A (en) * | 2014-10-30 | 2015-02-04 | 马辉 | Feed additive capable of preventing and treating gastric diseases of livestock and poultry |
| CN105919942B (en) * | 2016-07-07 | 2019-05-03 | 杭州爱力迈动物药业有限公司 | A kind of Dimetridazole soluble powder and preparation method thereof |
| CN106074514A (en) * | 2016-08-31 | 2016-11-09 | 上海邦森生物科技有限公司 | A kind of water solublity dimetridazole pre-mixing agent and preparation method thereof |
| CN106727350A (en) * | 2016-12-28 | 2017-05-31 | 潍坊宇洋药业有限公司 | A kind of lincomycin solid dispersion preparation and preparation method thereof |
| CN108553423A (en) * | 2018-05-16 | 2018-09-21 | 厦门汇承科技有限公司 | Water-soluble Dimetridazole pre-mixing agent for animals of one kind and preparation method thereof |
Citations (3)
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| CN1147380A (en) * | 1995-10-09 | 1997-04-16 | 张晓安 | Medicine compound for gastric and duodenal ulcer |
| CN101297805A (en) * | 2007-09-24 | 2008-11-05 | 天津生机集团有限公司 | Medicament composition for preventing and controlling enteritis necroticans of domestic birds |
| CN101966178A (en) * | 2010-07-26 | 2011-02-09 | 天津生机集团股份有限公司 | Composition for treating chicken proventriculitis and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1147380A (en) * | 1995-10-09 | 1997-04-16 | 张晓安 | Medicine compound for gastric and duodenal ulcer |
| CN101297805A (en) * | 2007-09-24 | 2008-11-05 | 天津生机集团有限公司 | Medicament composition for preventing and controlling enteritis necroticans of domestic birds |
| CN101966178A (en) * | 2010-07-26 | 2011-02-09 | 天津生机集团股份有限公司 | Composition for treating chicken proventriculitis and preparation method thereof |
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