CN102379939A - Drug composition for preventing and treating exogenous fever of livestock and poultry - Google Patents
Drug composition for preventing and treating exogenous fever of livestock and poultry Download PDFInfo
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Abstract
The invention relates to a compound Chinese and western drug composition for preventing and treating exogenous fever of livestock and poultry and belongs to the field of traditional Chinese veterinary medicine. The drug composition provided by the invention comprises the components including Bupleurum, cassia twig, herba schizonepetae, wild ginger, peach kernel and analgin. The compound Chinese and western drug has a synergistic effect, has a better effect on preventing and treating exogenous fever than that of prescribed preparations of chemical drug and TCM (Traditional Chinese Medicine) preparations, and can be used by persons with nonspecific symptoms of wind chill, wind heat or chills and fever, and has low cost of drug material and better market prospect.
Description
Technical field
The present invention relates to the pharmaceutical composition of the control poultry fever caused by exogenous pathogens that a kind of Chinese medicine and western medicine combines, belong to field of traditional Chinese veterinary.
Background technology
Fever caused by exogenous pathogens is meant the gas of being invaded by exogenous pathogen or warm epidemic disease poison, causes battalion to defend and becomes estranged, and the pathologic fervescence appears in the internal organs imbalance of YIN and YANG.Chinese veterinarian will experience due to the warm epidemic disease poison of pathogenic factor, be that main exogenous disease is generically and collectively referred to as epidemic febrile disease or claims epidemic febrile disease with the heating, wherein substantial connection is arranged with veterinary a lot of acute infectious disease of modern times.Fever caused by exogenous pathogens is the poultry common disease, and body temperature is higher, is mostly moderate heating or hyperpyrexia, and morbidity is anxious, and the course of disease is short, and calorific potential is heavy, and mortality rate is higher relatively, and tolerance does not in time extremely have a strong impact on fertility performance yet.
At present, the medicine that is used to treat the poultry fever caused by exogenous pathogens relatively seldom, most people can not be applied to animal with antipyretic because of receiving restrictions such as bio-safety, drug residue, treatment cost.
Dipyrone allows antipyretic analgesics for animals as national regulation, and not only antipyretic effect is fast for it, and price is very cheap, so the first-selected antipyretic of Chang Zuowei is used.But because of itself half-life very short, about 1～4 hour of t1/2 needs the repeated multiple times administration, is inappropriate for the modern plant of extensive intensive cultivation especially.Conventional Chinese medicine antipyretics such as Radix Bupleuri, Flos Lonicerae, Herba Houttuyniae often are restricted because effect too relaxes when veterinary clinic uses.
Summary of the invention
The pharmaceutical composition that the purpose of this invention is to provide a kind of new control poultry fever caused by exogenous pathogens.This pharmaceutical composition prescription is unique, reasonable.Combination treatment poultry fever caused by exogenous pathogens of the present invention not only can strengthening vital QI to eliminate pathogenic factors, relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, evacuation bring down a fever, but pain relieving warming the lung also, loosening bowel to relieve constipation, and curative effect is rapid, and effect is permanent.
The objective of the invention is to realize through following technical scheme:
The present invention provides a kind of pharmaceutical composition of preventing and treating the poultry fever caused by exogenous pathogens, and its ingredient is made up of Radix Bupleuri, Ramulus Cinnamomi, Herba Schizonepetae, Herba Asari, Semen Persicae, dipyrone.
The weight portion proportioning of each ingredient is in the pharmaceutical composition of the present invention: 10～60 parts of Radix Bupleuri, 10～60 parts of Ramulus Cinnamomi, 10～80 parts of Herba Schizonepetae, 3～12 parts of Herba Asaris, 10～60 parts in Semen Persicae, 10～40 parts of dipyrones.
Further, the weight portion proportioning of above-mentioned each ingredient is: 15～45 parts of Radix Bupleuri, 15～45 parts of Ramulus Cinnamomi, 20～60 parts of Herba Schizonepetae, 5～9 parts of Herba Asaris, 15～45 parts in Semen Persicae, 15～35 parts of dipyrones.
Further, the weight portion proportioning of each ingredient is in the pharmaceutical composition of the present invention: 30 parts of Radix Bupleuri, 30 parts of Ramulus Cinnamomi, 45 parts of Herba Schizonepetae, 6 parts of Herba Asaris, 30 parts in Semen Persicae, 30 parts of dipyrones.
Pharmaceutical composition of the present invention can be processed other dosage form, but for better reaching effect of the present invention, pharmaceutical composition optimizing injection of the present invention or oral formulations.
Wherein, described oral formulations is oral liquid, granule or powder.
Pharmaceutical composition of the present invention makes after can handling each raw material according to the formulation preparation method of routine, can add acceptable other pharmaceutic adjuvants of an amount of animal medicine in case of necessity again.
Wherein, described adjuvant comprises additives, filler (diluent), fluidizer, binding agent, correctives etc.
Described additives comprise: antibacterial, solubilizing agent, cosolvent and pH regulator agent and antioxidant etc.
Additives can be Tween 80, benzyl alcohol, benzoic acid; Propylene glycol, ethanol, parabens, hydrochloric acid, citric acid or sodium hydroxide (potassium), a kind of, two or more mixing in sodium bicarbonate, sodium carbonate, phosphate, citrate, sodium sulfite, sodium sulfite, sodium pyrosulfite, the disodiumedetate etc.
Described filler is a kind of, two or more mixing in lactose, cane sugar powder, chitosan, Pulvis Talci, starch, carboxymethyl starch sodium, dextrin, defatted rice bran, wheat bran powder, wheat bran, maize cob meal, powdered rice hulls, sizing and the Semen sojae atricolor PIFEN etc.
Described fluidizer is one or both mixing of Pulvis Talci, micropowder silica gel.
Described binding agent is a kind of, two or more mixing in hypromellose, sodium carboxymethyl cellulose, gelatin, polyvinylpyrrolidone, dextrin, the polyethylene glycols adjuvant.
Described correctives is a kind of, two or more mixing in sucrose, lactose, glucose, stevioside, betanin, cyclamate, sucralose, saccharin sodium, xylitol, protein sugar, fructose, Fructus Citri Limoniae oil butyric acid, butyl lactate, ethyl lactate, Oleum Anisi Stellati, Semen Arecae seed oil and big scallion oil, the fragrant citrus powder.
The preparation of control poultry fever caused by exogenous pathogens drug injection of the present invention and oral liquid can be carried out as follows: 1) with Radix Bupleuri, Ramulus Cinnamomi, Herba Schizonepetae, Herba Asari pulverize separately, mixes, soaks the back and extract volatile oil, and subsequent use; 2) 1) in extraction volatile oil after medicinal residues, medicine liquid mixture in add Semen Persicae, decoct 2～3 times, collecting decoction concentrates, precipitate with ethanol 2 times reclaims ethanol, promptly gets extracting solution, cold preservation is subsequent use; 3) get add the antioxidant dissolving under the situation that an amount of water for injection heats while stirring after, be cooled to below 40 ℃, add 1) in the volatile oil and 2 that extracts) in prepared extracting solution, stir; Add suitable cosolvent and make solution clear and bright, add dipyrone again, be stirred to fully dissolving, adjust pH under the nitrogen state rapidly filling; Filter, nitrogen is filled in packing; Seal, sterilization promptly gets injection and oral liquid.
The preparation of control poultry fever caused by exogenous pathogens medicinal granule of the present invention can be carried out as follows: 1) with Radix Bupleuri, Ramulus Cinnamomi, Herba Schizonepetae, Herba Asari pulverize separately; Mix; Soak the back and extract volatile oil, in volatile oil, add the adjuvant cyclodextrin, it is subsequent use to be prepared into cyclodextrin clathrate; 2) add Semen Persicae again in the medicinal residues after extracting volatile oil, the medicine liquid mixture, decocte with water twice merges decoction liquor, concentrate, and precipitate with ethanol, filtered and recycled ethanol directly is spray dried to dry extract, or is condensed into reduced vacuum oven dry again behind the cream, is ground into extract powder; 3) with 1) in the volatile oil clathrate compound, 2 that makes) in the extract powder and the former powder of dipyrone that make fully mix, can admix an amount of correctives and wetting agent, place mixer to stir and process soft material, granulate then, drying, granulate, packing promptly gets.
The preparation of the drug powder of control poultry fever caused by exogenous pathogens of the present invention can be carried out as follows:
Powder method for preparing (1): the method for preparing according to above-mentioned preparation granule prepares cyclodextrin of volatile oil clathrate, extract powder, and the former powder of the two and dipyrone is fully mixed, and adds correctives, filler then to full dose; Abundant mixing; Cross 50 mesh sieves, packing promptly gets.
Powder method for preparing (2): Radix Bupleuri, Ramulus Cinnamomi, Herba Schizonepetae, Herba Asari, Semen Persicae are dried respectively, be ground into 50～300 purpose powder, mix after adding dipyrone, can add starch simultaneously or micropowder silica gel improves liquidity, abundant mixing, packing promptly gets.
Compared with prior art, the invention has the beneficial effects as follows:
(1) prescription is rationally unique: during the poultry fever caused by exogenous pathogens, and often with dyspnea, diseases such as cough and asthma, constipation, arthralgia.Above-mentioned a few flavor medicine compatibility treatment poultry fever caused by exogenous pathogens not only can strengthening vital QI to eliminate pathogenic factors, relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, evacuation bring down a fever, but also pain relieving warming the lung, loosening bowel to relieve constipation, and evident in efficacy, long action time;
(2) cost is low: the chemical medicine dipyrone is cheap in the prescription, and Chinese medicine is common medical material.And the amount ratio traditional Chinese medicines consumption of western compound preparation is few, uses conveniently, can reach better effect again, reduces cost;
(3) toxic and side effects is little: toxicity is not seen in three multiple dose medications yet, and in the process of using said composition treatment livestock and poultry, does not find obvious adverse reaction.
Through the following example the present invention will be described more specifically, and it should be understood that said embodiment only is for the present invention is described, rather than limit scope of the present invention by any way.
The specific embodiment
Embodiment 1
The present embodiment medicine is made by following raw material: Radix Bupleuri 3000g, Ramulus Cinnamomi 3000g, Herba Schizonepetae 4500g, Herba Asari 600g, Semen Persicae 3000g, dipyrone 3000g.
The preparation process is following: 1) with Radix Bupleuri, Ramulus Cinnamomi, Herba Schizonepetae, Herba Asari pulverize separately, mixing, put in the volatile oil extractor, soaked 2 hours, the amount that adds water is more than 4 times of medical material gross weight.The above volatile oil that fully extracts of boiling reflux 6h, subsequent use; 2) 1) in extract in medicinal residues behind the volatile oil, the medicine liquid mixture and add Semen Persicae, decocte with water 3 times, it is each that to add the amount that decocts water be more than 4 times of medical material gross weight; Collecting decoction is concentrated into 0.5 times of crude drug total amount, adds ethanol; Make the content of alcohol reach 60%, deposition 12h.After reclaiming ethanol, add ethanol again, make pure content reach 70%, deposition 12h reclaims ethanol, promptly gets extracting solution, and cold preservation is subsequent use; 3) get add antioxidant sodium sulfite 36g dissolving under the situation that an amount of water for injection heats while stirring after, be cooled to below 40 ℃, add 1) in the volatile oil and 2 that extracts) in prepared extracting solution, stir; Add an amount of Tween 80 and make solution clear and bright, add dipyrone again, be stirred to fully dissolving, adjust pH to 4.5 under the nitrogen state rapidly filling; Add the injection water to total amount 10000ml, filter, nitrogen is filled in packing; Seal, sterilization promptly gets injection.
Embodiment 2
The present embodiment medicine is made by following raw material: Radix Bupleuri 1000g, Ramulus Cinnamomi 1000g, Herba Schizonepetae 1000g, Herba Asari 300g, Semen Persicae 1000g, dipyrone 1000g.
The method for preparing injection according to embodiment 1 prepares oral liquid and promptly gets.
Embodiment 3
The present embodiment medicine is made by following raw material: Radix Bupleuri 6000g, Ramulus Cinnamomi 6000g, Herba Schizonepetae 8000g, Herba Asari 1200g, Semen Persicae 6000g, dipyrone 4000g.
The preparation process is following: 1) with Radix Bupleuri, Ramulus Cinnamomi, Herba Schizonepetae, Herba Asari pulverize separately, mix, insert in the volatile oil extractor, soaked 2 hours, the amount that adds water is to be preferably more than 4 times of medical material gross weight there not to be medical material.The above volatile oil that fully extracts of boiling reflux 6h adds the adjuvant beta-schardinger dextrin-in volatile oil, be prepared into cyclodextrin clathrate, and is subsequent use; 2) add Semen Persicae again in the medicinal residues after extracting volatile oil, the medicine liquid mixture, decoct three times, each amount of water was not advisable to have medical material; Merge decoction liquor, be concentrated into 0.5 times of medical material total amount, add ethanol; Make pure content reach 60%; Precipitate 12 hours, filtered and recycled ethanol directly is spray dried to dry extract; 3) with 1) in the volatile oil clathrate compound, 2 that makes) in the extract powder and the former powder of dipyrone that make fully mix, can admix an amount of lactose as filler and correctives, make total amount reach 13400g; Add an amount of 60% do ethanol as correctives and ethanol as wetting agent, place mixer to stir and process soft material, granulate then; Dry; Granulate, packing promptly gets granule.
Embodiment 4
The present embodiment medicine is made by following raw material: Radix Bupleuri 1000g, Ramulus Cinnamomi 1000g, Herba Schizonepetae 1000g, Herba Asari 300g, Semen Persicae 1000g, dipyrone 4000g.
Above-mentioned Chinese medicine of the five flavours oven dry is ground into 50 purpose powder, sneaks into dipyrone after the mixing again, abundant mixing, packing promptly gets powder.
Embodiment 5
The present embodiment medicine is made by following raw material: Radix Bupleuri 6000g, Ramulus Cinnamomi 6000g, Herba Schizonepetae 8000g, Herba Asari 1200g, Semen Persicae 6000g, dipyrone 1000g.
According to the method for preparing of embodiment 3 prepare the cyclodextrin of volatile oil clathrate, extract powder fully mixes with dipyrone.Add cane sugar powder as sweeting agent and starch as filler to total amount 10000g, fully mixing is crossed 50 mesh sieves, packing promptly gets powder.
Embodiment 6
The present embodiment medicine is made by following raw material: Radix Bupleuri 1500g, Ramulus Cinnamomi 1500g, Herba Schizonepetae 2000g, Herba Asari 500g, Semen Persicae 1500g, dipyrone 1500g.
Method for preparing according to embodiment 1 is prepared into injection.
Embodiment 7
The present embodiment medicine is made by following raw material: Radix Bupleuri 4500g, Ramulus Cinnamomi 4500g, Herba Schizonepetae 6000g, Herba Asari 900g, Semen Persicae 4500g, dipyrone 3500g.
Method for preparing according to embodiment 3 is prepared into granule.
Embodiment 8
The present embodiment medicine is made by following raw material: Radix Bupleuri 1500g, Ramulus Cinnamomi 1500g, Herba Schizonepetae 2000g, Herba Asari 500g, Semen Persicae 1500g, dipyrone 3500g.
Above-mentioned Chinese medicine of the five flavours oven dry is ground into 300 purpose powder, mixes, add the micropowder silica gel of an amount of same particle sizes, improve liquidity, sneak into dipyrone again, abundant mixing, packing promptly gets powder.
Embodiment 9
The present embodiment medicine is made by following raw material: Radix Bupleuri 4500g, Ramulus Cinnamomi 4500g, Herba Schizonepetae 6000g, Herba Asari 900g, Semen Persicae 4500g, dipyrone 1500g.
Method for preparing according to embodiment 3 is prepared into granule.
Embodiment 10
The present embodiment medicine is made by following raw material:
Radix Bupleuri 5000g, Ramulus Cinnamomi 5000g, Herba Schizonepetae 6000g, Herba Asari 1000g, Semen Persicae 5000g, dipyrone 3600g.
Above-mentioned five kinds of Chinese medicine is dried respectively, be ground into 100 purpose powder, mix, add an amount of Pulvis Talci and improve liquidity, sneak into dipyrone again, abundant mixing, packing promptly gets.
Below further specify beneficial effect of the present invention through test:
Test Example 1 medicine of the present invention is to the impact effect of Oleum Terebinthinae pyrogenicity rabbit body temperature
1 test material and method
1.1 the trial drug trial drug is embodiment 1 a preparation injection; Control drug (1): commercially available content is 30% analgin injection; Control drug (2): homemade injection that contains Chinese medicine ingredients in the pharmaceutical composition of the present invention; Its preparation method: get the above-mentioned 5 flavor Chinese medicines identical with embodiment 1 recipe quantity; Extract volatile oil, Chinese medicine extraction liquid according to identical Chinese medicine extraction method; Be mixed with injection according to identical method then, just in process for preparation, do not add dipyrone.Chinese medicine content is identical in the injection of the medicament contg of said preparation and embodiment 1 preparation, is 1ml: 1.4g (Chinese crude drug).
1.2 40 of experimental animal healthy rabbits, average weight are 2.2 ± 0.3 kilograms.
1.3 test method is equally divided into 4 groups at random with rabbit, 10 every group.To all test rabbit back subcutaneous injection Oleum Terebinthinae 0.4ml/kg, rabbit body temperature on average raises about 2.0 ℃ after 24 hours.Give the 1st, 2,3 group of intramuscular injection medicine of the present invention, control drug (1) and control drug (2) 0.5ml/kg respectively; The 4th group is the blank group, intramuscular injection normal saline 0.5ml/kg.0.5h, 1h, 2h, 3h, 4h, 5h, 6h, 12h respectively survey body temperature one time after the administration.
2 result of the tests and analysis
Result of the test is seen table 1
Table 1 medicine of the present invention is to the impact effect of Oleum Terebinthinae pyrogenicity rabbit body temperature
The result finds: the body temperature of analgin injection group is dropped rapidly to nearly normal body temperature in medication in 1 hour, begins bounce-back again but keep after 3 hours; The Chinese medicine injection matched group medication after 1 hour body temperature descend to some extent, be maintained to 12 hours, but be not reduced to the normal body temperature scope; Medicine of the present invention is dropped rapidly to nearly normal body temperature in medication in 1 hour, and body temperature still is lower than level before the medication after 12 hours, and antipyretic effect can be kept more than 10 hours.Result of the test proves that medicine of the present invention is brought down a fever antiinflammation by force and lastingly, can make the rabbit body temperature of artificial pyrogenicity reduce to normal level, and its antiinflammation of bringing down a fever significantly is superior to analgin injection and pure Chinese medicine injection.
Test Example 2 medicinal applications of the present invention are observed in the toxic and side effects of pig, chicken.
1 test material and method
1.1 the trial drug trial drug is the granule of embodiment 1 preparation injection and embodiment 3 preparations.
1.2 60 of the healthy piglets of experimental animal, average weight is 30 ± 0.55 kilograms.120 of healthy 10 Japanese instar chicklings.
1.3 test method is divided into 4 groups at random with piglet, 15 every group.1st, 2,3 groups is test group, injection 0.3ml/kg, 0.6ml/kg, the 0.9ml/kg of difference intramuscular injection embodiment 1 preparation, every day 1 time, logotype 3 days; The 4th group is the blank group, not administration, the normal raising.To observing situation such as record untoward reaction, diet desire, the mental status and body weight change 15 days after all test piglet medications.
Chickling is divided into 4 groups at random, and 30 every group, the 1st, 2,3 group is test group; With the granule of embodiment 3 preparation respectively according to 2g: the ratio of 1kg, 4g: 1kg, 6g: 1kg is converted water, and stirring and dissolving freely drinks for respectively preceding 3 groups of chickling; Drank liquid medicine every day 2 hours, and connected and drank 3 days; The 4th group is the blank group, not administration, the normal raising.All are tested after the young medication observed situation such as record untoward reaction, diet desire, the mental status and body weight change 15 days.
2 result of the tests and analysis
Compare with the matched group of not medication, obvious adverse reaction does not all take place in the piglet of preceding 3 groups of medications, and diet is desired, the mental status is all normal, and it is also little that average weight increases difference.
Compare with the matched group of not medication, obvious adverse reaction does not all take place in the chickling of preceding 3 groups of medications, and diet is desired, the mental status is all normal, and it is little that average weight increases difference.
Above-mentioned result of the test explanation, poisonous side effect of medicine of the present invention is little, can not influence the growth promoter of animal after the application.
The effect of Test Example 3 Drug therapy pig blue-ear disease of the present invention
1. materials and methods
1.1 trial drug is got the injection of embodiment 6 preparations as investigational agent; The commercially available analgin injection for animals of control drug (1); Control drug (2) is with the homemade injection of Chinese medicine ingredients in the pharmaceutical composition of the present invention; Its preparation method: get the above-mentioned 5 flavor Chinese medicines identical with embodiment 6 recipe quantities; Extract volatile oil and Chinese medicine extraction liquid according to identical Chinese medicine extraction method; Be mixed with injection according to identical method then, just in process for preparation, do not add dipyrone.Chinese medicine content is identical in the injection of the medicament contg of said preparation and embodiment 3 preparations, is 1ml: 1.4g (Chinese crude drug).
1.2 80 growing and fattening pigs of experimental animal natural infection pig blue-ear disease.
In December, 2009, the cold current invasion and attack, 100 bull growing and fattening pigs sudden onset of Beijing plant, fervescence reaches more than 40 ℃, the inflammation of eye conjunctiva, blepharoedema, cough, respiratory symptoms such as asthma; Part Corii Sus domestica skin shows livid purple color, and rear quarters is unable, can not stand or nervous symptoms such as ataxia.According to incidence, clinical symptoms and pathological change, this swinery of tentative diagnosis is that the reproductive and respiratory syndrome poison infects.Select that wherein body weight is close, 80 of the typical pigs of the state of an illness make an experiment, and observe the clinical efficacy of medicine of the present invention.
1.3 test method is divided into 4 groups at random with 80 sick pigs, 20 every group.The 1st group is drug group of the present invention, intramuscular injection medicine 0.3ml/kg of the present invention, 1 day 1 time, logotype 3 days; The 2nd group is the analgin injection matched group, intramuscular injection control drug (1), and usage and dosage is with the 1st group; The 3rd group is the Chinese medicine injection matched group, intramuscular injection control drug (2), and usage and dosage is with the 1st group; The 4th group is the blank group, not administration.To all experimental animals, observed 15 days continuously during the medication and after the medication, write down situation such as death toll, symptom variation, drink, desire and the mental status every day.
1.4 curative effect determinate standard is invalid: administration and in the observation period, there do not have effect or DeGrain to be regarded as to be invalid; Effectively: administration and various clinical symptom remissions in the observation period, body temperature reduces, improvements such as blepharoedema, skin color, dyspnea and nervous symptoms, the mental status takes a turn for the better, and appetite increases, or the pig of curing fully all is regarded as effectively; Cure: various clinical symptom disappearance, body temperature, to breathe and recover normal, appetite, the mental status are good, and drug withdrawal was not recurred after one week.
2. result of the test and analysis
Result of the test is seen table 2.Test data adopts SPSS12.0 software to carry out variance analysis, and the result of the test data are carried out significance test.
The therapeutic effect of table 2 pig blue-ear disease
Result of the test is found: in process of the test, the pig of drug group of the present invention is except test initial stage pig too sudden death is died because of falling ill, and other pigs all survival also take a turn for the better, and the total effective rate of medication therapy groups of the present invention is 95%, and cure rate is 75%; The total effective rate of analgin injection matched group is 60%, and cure rate is merely 45%; Chinese medicine injection matched group total effective rate 80%, cure rate are 60%; The matched group total effective rate of not administration is 55%, and cure rate also is merely 40%.Can find out that from result of the test the effect of preceding 3 groups of medication groups is better than the 4th group of not medication matched group, but through x
2Check; The difference of analgin injection matched group and blank group is remarkable (P>=0.05) not, promptly do not have the statistics notable difference, and this is because dipyrone has only simple analgesic anti-inflammatory analgesic action; There is not antivirus action, so not good to this virosis therapeutic effect of reproductive and respiratory syndrome; The Chinese medicine injection matched group is compared with the blank group, and significant difference (0.01＜P＜0.05) explains that Chinese medicine component of the present invention has antiviral effect clearly; Drug group of the present invention is compared with the analgin injection matched group; Difference is (P＜0.01) extremely significantly; Compare significant difference (0.01＜P＜0.05) with the Chinese medicine injection matched group; Chinese and Western of the present invention compound medicament composition ability treating both the principal and secondary aspects of a disease is described, this type of pig blue-ear disease fever caused by exogenous pathogens disease is had splendid curative effect.
The effect of Test Example 4 chemoprophylaxis pig blue-ear disease of the present invention
1. materials and methods
1.1 trial drug is got the powder of embodiment 5 preparations as trial drug.
1.2 100 of the growing and fattening pigs of not morbidity in the pig farm of the above-mentioned generation reproductive and respiratory syndrome of experimental animal
1.3 test method is divided into 2 groups with experimental animal, 50 every group, the 1st group is the drug test group, and feedstuff per ton is admixed 2 kilograms of trial drugs, feeds for 1 week; Other 1 group is the blank group, not administration, the normal raising.To all experimental animals, observing 21 days situation such as record incidence, diet desire, the mental status during the medication and after the medication continuously.
2. result of the test and analysis
Result of the test is seen table 3
The effect of table 3 prevention pig blue-ear disease
In the process of the test, the pig of drug group of the present invention had 3 and 1 pig the symptom of hyperpyrexia, cough occur on the the 1st, 2 day respectively in test, and 4 swine diseases close friends change after continuing administration in several days, do not see that except these 4 obvious clinical symptoms appears in other pigs; The pig morbidity that the pig of blank group all has a number not wait every day in the observation period had 26 pigs by the 20th day one and obvious clinical symptoms occurs.The protective rate of result of the test explanation drug group of the present invention reaches 92%, and the prevention of pig blue-ear disease is had fabulous effect.
The effect of Test Example 5 Drug therapy newcastle diseases of the present invention and pasteurellosis bacillus mixed infection
1 materials and methods
1.1 trial drug is got the granule of embodiment 3 preparations as trial drug; Control drug (1) is homemade granule that contains Chinese medicine ingredients in the pharmaceutical composition of the present invention; Method for preparing: the above-mentioned Chinese medicine of the five flavours of getting embodiment 3 identical recipe quantities; Prepare volatile oil clathrate compound and the Chinese medical concrete powder fully mixes according to identical method for preparing, admix identical adjuvant, process granule with same method; Its medicament contg is identical with the Chinese medicine content of the granule of embodiment 3 preparations, is 1: 2 (Chinese crude drug); Control drug (2): homemade dipyrone granule; Its preparation method: get the former powder of dipyrone with embodiment 3 identical recipe quantities; Add identical adjuvant and be prepared into granule, dipyrone content is identical in the granule of its dipyrone content and embodiment 3 preparations is 30%.
1.2 the sick chicken of 440 newcastle diseases of experimental animal and pasteurellosis bacillus mixed infection.
In January, 2010, more than 3000 in chicken farm, Beijing becomes the chicken mass-sending to give birth to infectious disease, has just begun the part chicken and 43～43.5 ℃ of fervescence occurred, shakes the head, and mouth breathing is not eaten food, happiness drinking-water.The state of an illness spreads to whole chicken crowd after several days, and has chicken to begin death.Most of chicken essence god is depressed, and appetite descends, and feather is thick disorderly unglazed, drowsiness, row's yellow green loose stool, and crop expands, and a large amount of mucus is flowed out in the oral cavity, mouth breathing, nervous symptoms appears in the sick chicken of minority.Pathological anatomy is seen cecal tonsil enlargement, hemorrhage; Small intestinal, cecum mucosa have the petechia; The glandular stomach nipple has petechia, necrosis.According to incidence, the pathological change of cuing open inspection and laboratory pathogen inspection tentative diagnosis is newcastle disease and pasteurellosis bacillus mixed infection.In order to verify the curative effect of medicine of the present invention, we have selected typical 440 the sick chickens of symptom as experimental animal.
1.3 test method is divided into 4 groups at random with 440 sick chickens, 110 every group.The 1st group for drug group of the present invention, and the granule 100g of embodiment 4 preparations is converted 50 kilograms in water, lets chicken freely drink, and connects and drinks 5 days, in feedstuff, admixes the compound sulfadiazine pre-mixing agent simultaneously and carries out antibacterial therapy, lets the chicken free choice feeding, logotype 5 days; The 2nd group is pure Chinese medicine granules matched group, adds control drug (1) in the drinking-water, and usage and dosage is also used the compound sulfadiazine pre-mixing agent simultaneously and carried out antibacterial therapy with the 1st group; The 3rd group is dipyrone granule matched group, adds control drug (2) in the drinking-water, and usage and dosage is also used the compound sulfadiazine pre-mixing agent simultaneously and carried out antibacterial therapy with the 1st group; The 4th group is the blank group, only carries out antibacterial therapy with the compound sulfadiazine pre-mixing agent.To all experimental animals, observed 20 days continuously during the medication and after the medication, write down situation such as death toll, symptom variation, diet desire and the mental status every day.
1.4 curative effect determinate standard is invalid: administration and in the observation period, there do not have effect or DeGrain to be regarded as to be invalid; Effectively: administration and various clinical symptom remissions in the observation period, respiratory symptom is clearly better, and diarrhoea alleviates, and appetite, the mental status take a turn for the better, or the chicken of curing fully all is regarded as effectively; Cure: various clinical symptom disappearance, breathe recover normal, defecation is normal, appetite, the mental status are good, drug withdrawal was not recurred after one week.
2 result of the tests and analysis
Result of the test is seen table 4.Test data adopts SPSS12.0 software to carry out variance analysis, and the result of the test data are carried out significance test.
The effect of table 4 treatment newcastle disease and fowl cholera mixed infection
The total effective rate of drug group of the present invention is 96.4%, and cure rate is 84.5%; The total effective rate of pure Chinese medicine granules matched group is merely 80.9%, and cure rate is 66.4%; The total effective rate of dipyrone granule matched group is 65.5%, and cure rate is 56.4%; The total effective rate of blank group is 60.9%, and cure rate is 50%.Can find out that from result of the test preceding 3 groups that use antipyretic are better than the 4th group, explain that in time using antipyretic has extraordinary synergistic therapeutic effect to the symptom of chicken morbidity back fervescence.Check through x2; Drug group of the present invention is compared with the Chinese medicine granules matched group; Significant difference (0.01＜P＜0.05); Compare difference extremely significantly (P＜0.01) with the dipyrone granule, explain that the effect of Chinese and Western of the present invention compound preparation is better, newcastle disease and fowl cholera mixed infection are had this splendid therapeutic effect.
Claims (6)
1. pharmaceutical composition of preventing and treating the poultry fever caused by exogenous pathogens is characterized in that ingredient is made up of Radix Bupleuri, Ramulus Cinnamomi, Herba Schizonepetae, Herba Asari, Semen Persicae, dipyrone.
2. the pharmaceutical composition of control poultry fever caused by exogenous pathogens according to claim 1, it is characterized in that: the weight portion proportioning of above-mentioned each ingredient is: 10～60 parts of Radix Bupleuri, 10～60 parts of Ramulus Cinnamomi, 10～80 parts of Herba Schizonepetae, 3～12 parts of Herba Asaris, 10～60 parts in Semen Persicae, 10～40 parts of dipyrones.
3. the pharmaceutical composition of control poultry fever caused by exogenous pathogens according to claim 2, it is characterized in that: the weight portion proportioning of above-mentioned each ingredient is: 15～45 parts of Radix Bupleuri, 15～45 parts of Ramulus Cinnamomi, 20～60 parts of Herba Schizonepetae, 5～9 parts of Herba Asaris, 15～45 parts in Semen Persicae, 15～35 parts of dipyrones.
4. the pharmaceutical composition of control poultry fever caused by exogenous pathogens according to claim 3, it is characterized in that: the weight portion proportioning of above-mentioned each ingredient is: 30 parts of Radix Bupleuri, 30 parts of Ramulus Cinnamomi, 45 parts of Herba Schizonepetae, 6 parts of Herba Asaris, 30 parts in Semen Persicae, 30 parts of dipyrones.
5. according to the pharmaceutical composition of each described control poultry fever caused by exogenous pathogens of claim 1～4, it is characterized in that: described pharmaceutical composition is injection or oral formulations.
6. the pharmaceutical composition of control poultry fever caused by exogenous pathogens according to claim 5, it is characterized in that: described oral formulations is oral liquid, granule or powder.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520268A (en) * | 2013-10-31 | 2014-01-22 | 青岛施维雅生物制药有限公司 | Traditional Chinese medicine extract injection fluid and preparation method thereof |
| CN105497429A (en) * | 2016-02-24 | 2016-04-20 | 济南亿民动物药业有限公司 | Preparation method of traditional Chinese medicine compound and preparation improving productivity and immunity of broiler |
| CN106511819A (en) * | 2016-12-26 | 2017-03-22 | 中悦民安（北京）科技发展有限公司 | Traditional Chinese medicinal composition used for fever abatement of animals |
-
2010
- 2010-09-06 CN CN201010273523.5A patent/CN102379939B/en active Active
Non-Patent Citations (2)
| Title |
|---|
| 聂成富: "中西兽医结合治疗猪发烧", 《中兽医学杂志》 * |
| 蔡振林: "中西结合治牛流行性感冒", 《中兽医学杂志》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520268A (en) * | 2013-10-31 | 2014-01-22 | 青岛施维雅生物制药有限公司 | Traditional Chinese medicine extract injection fluid and preparation method thereof |
| CN103520268B (en) * | 2013-10-31 | 2015-11-11 | 青岛施维雅生物制药有限公司 | For the Traditional Chinese medicine extract injection fluid and preparation method thereof of domestic animal |
| CN105497429A (en) * | 2016-02-24 | 2016-04-20 | 济南亿民动物药业有限公司 | Preparation method of traditional Chinese medicine compound and preparation improving productivity and immunity of broiler |
| CN106511819A (en) * | 2016-12-26 | 2017-03-22 | 中悦民安（北京）科技发展有限公司 | Traditional Chinese medicinal composition used for fever abatement of animals |
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| CN102379939B (en) | 2014-09-17 |
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