CN103704513B - Feed for treating swine plague and preparation method thereof - Google Patents
Feed for treating swine plague and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a feed for treating swine plague and a preparation method of the feed. The feed comprises corns, soybean meal, peanut meal, wheat bran, mountain flour, fish meal, sweet potato flour, kelp powder, vitamin E and a traditional Chinese medicinal additive. The feed has the beneficial effects that the feed provided by the invention comprises the traditional Chinese medicinal additive which is mainly used for clearing heat, detoxifying, ventilating the lung and resolving phlegm and assists in soothing the throat and diminishing inflammation to relieve pain; under the combined action, the traditional Chinese medicinal additive is matched with other raw materials, so that the feed has the advantages of obvious treating effect for treating the swine plague of pigs, high curing rate, poor side effect, difficulty in reappearing and low cost.
Description
Technical field
The present invention relates to herbal medicine technical field, particularly a kind of feed being used for the treatment of swine plague and preparation method thereof.
Background technology
Swine plague is a kind of acute infectious disease (swine plague) caused by multiple lethal Pasteurella, is commonly called as " lockjawed laryngitis ", " swollen neck pest ".Acute or chronic process, the acute change in septicemia, bottleneck throat swelling, highly has difficulty in breathing.Pasteurella multocida can infect many animals, and pig is wherein a kind of, and the pig at various age all can infection morbidity.It is generally acknowledged that this bacterium is a kind of conditionity pathogen, when pig is in bad external environment, as cold, sultry, weather drastic change, humidity, crowded, improper ventilation, nutritional deficiency, fatigue, long-distance transport etc., cause the resistance of pig to decline, at this moment pathogen breeds in a large number and causes morbidity.Sick pig is through the discharge of bacteria such as secretion, excreta in addition, and pollute drinking-water, feed, apparatus and external environment, being transmitted to health pig through alimentary canal, is also the important routes of infection.Also cause of disease can be discharged, by the spittle through respiratory tract infection by cough, sneeze.In addition, hematophagus bites skin and mucous membrane wound all can infect.This disease is general without significantly seasonal, but to cold and heat succeed each other, climate variability, high temperature season is multiple, general in sporadic or endemicity.
To many animals with have pathogenic per capita, with the most susceptible of pig, occur without obviously seasonal, but to cold and heat succeed each other, weather drastic change, moist, the factors such as rainy generation is more, and malnutritive, long-distance transport, rearing conditions change, bad promote that this disease occurs, often concentratedly fall ill.
The most acute, acute and chronic type is divided into according to course of disease length and clinical manifestation.Most acute: do not occur any symptom, sudden onset, dead rapidly.The course of disease slightly elder shows body temperature and is elevated to 41 ~ 42 DEG C, and appetite is absolutely useless, and expiratory dyspnea, rapidly, visual mucous membrane cyanosis, purplish-red macula appears in skin in heartbeat.Bottleneck throat and neck heating, red and swollen, hard, severe patient is extended down to the basal part of the ear, front.Sick pig breathes and is the devil, normal in sitting position of dog gesture, and extend neck, sometimes can send sound of stridulating, mouth and nose flow out white foam, sometimes with color.Once there is serious expiratory dyspnea, the state of an illness often worsens rapidly, very fast dead.Death rate Chang Gaoda 100%, spontaneous remission person is rare.Acute: this type is the most common.Body temperature is increased to 40 ~ 41 DEG C, and the initial stage is spastic dry cough, expiratory dyspnea, mouth and nose flow out foam, be sometimes mixed with blood, after become wet cough.With disease, breathe more difficult, often make sitting position of dog gesture, chest palpation has pain.Lassitude, poor appetite or absolutely useless, there is erythema in skin, later stage languishment, does not rise sleepingly, how because of death by suffocation.The course of disease 5 ~ 8 days, the dead does not transfer to chronic.Chronic type: main manifestations is pneumonia and chronic gastroenteritis.Time have persistent cough and expiratory dyspnea, have fluid resistance or purulence nose liquid a little.Arthroncus, often has diarrhoea, poor appetite, malnutritive, has scab sample eczema, grows and stops, skeletonize, the course of disease more than 2 weeks, and majority occurs dead.
General incubation period is 1-5 days.Most acute, night is normal food also, and m seq and dead, often can't see reveal any symptoms, and the course of disease is slightly long, body temperature is elevated to 41-42 DEG C, and appetite is absolutely useless, and asthenia universalis, does not rise sleepingly, expiratory dyspnea, in sitting position of dog gesture, mouth and nose flow out foam, course of disease 1-2 day, the death rate 100%.Acute (pleuropneumonia type), body temperature 40-41 DEG C, spastic dry cough, discharging sputum is mucus or purulence, expiratory dyspnea, and rear one-tenth is wet, pain is coughed, chest pain, and in dog, seat, dog crouch, first constipation, rear diarrhoea, visible congestive blood spots on skin.Chronic type, continues there is cough, expiratory dyspnea, and a small amount of mucus of nose stream, sometimes occurs arthroncus, become thin, diarrhoea, and dead through exhaustion in more than 2 weeks, the most acute and acute pig of case fatality rate 60-70%. shows as septicemia and pleuropneumonia.Affected pig portion is red and swollen, expiratory dyspnea, mucous membrane and skin cyanosis, body temperature 41-42 DEG C, course of disease 1-2 day.Chronic type is shown in persistent cough, and expiratory dyspnea, suppurating property nose liquid, becomes thin, exhaustion.Most acute: whole body mucous membrane, serous coat and hypodermis have blutpunkte, especially with the hemorrhagic oedema of larynx and surrounding tissue thereof for feature.Cut skin of neck, have the yellowish or grey cyan cellulosic slurries of a large amount of glue peptone sample.Lymph nodes of body as a whole swelling, hemorrhage.The external membrane of heart and pericardium there is blutpunkte.Lung acute edema.Spleen has hemorrhage but not enlargement.Skin has blood spots.Bleeding of gastrointestinal mucosa inflammation.Acute: except having the pathology of most acute, its distinctive pathology is fibrinous pneumonia.Main manifestations is have volume foam mucus in trachea-bronchial epithelial cell.Lung has Gan Bian district in various degree, with wind-puff and oedema.Often have necrosis region in the Fei Ganbian district that the course of disease is long, between lobulus pulmonis, serosity infiltrates, and lung tangent plane is marbleized appearance, and pleura has cellulosic attachment, pleura and sick adhesion of lung.Thoracic cavity and hydropericardium.Chronic type: corpse skeletonize, anaemia.Lungs You Ganbian district, and have yellow or grey necrosis region, there is connective tissue outside, includes caseous substance; Some formation cavities, communicate with bronchus.Pericardium and pleural effusion, thoracic cavity has cellulosic calm, and pleura is plump, usually with sick adhesion of lung.Sometimes see there is necrosis region at intercostal muscle, peribronchial lymph node, mediastinal lymph nodes and tonsillotome, joint and hypodermis.Acute: except the hemorrhagic lesions of whole body mucous membrane, organa parenchymatosum, lymph node, distinctive pathology is fibrinous pneumonia, has Gan Bian district in various degree.Pleura and adhesion of lung, lung tangent plane is marble grain, thoracic cavity, hydropericardium, and trachea-bronchial epithelial cell mucosa irritation has foam-like mucus.Chronic type: Fei Ganbian district expands, has lark or grey necrosis, inside has caseous substance, and some formation cavities, highly become thin, anaemia, hypodermis is shown in necrosis region.
Morbus acutissimus example, due to urgency of falling ill, often has little time treatment, sick pig dead.Penicillin, streptomysin and Cyclomycin family antibiotic have certain curative effect to swine plague.Antibiotic and sulfa drug share, as tetracycline+sulfadimidine, and tylosin+sulfadimidine.Special it is emphasized that this bacterium very easily develops immunity to drugs in treatment, therefore with good conditionsily should do drug sensitive test, select sensitive medicaments treatment.Prevention: the annual spring and autumn of (1) epidemic prevention regularly carries out twice immunity inoculation with swine plague aluminium hydroxide formaldehyde vaccine or the oral weak toadstool seedling of swine plague.Also brickpox, swine plague aluminium hydroxide Combined vaccine can be selected, the weak malicious triple vaccine of swine fever, brickpox, swine plague.Vaccine inoculation, a few days ago with in latter 7 days, forbids antibacterials.(2) improve feeding and management when conditions permit, advocate early weaning.Adopt the production routine of all-in and all-out; Enclosed swinery, reduces and draws pig from the outside; Reducing the measures such as the density of swinery may be helpful to the meeting of this disease of control.(3) chemoprophylaxis is to regular incidence pig farm, will add antimicrobial and prevent in feed.According to this sick propagating characteristic, first anti-system should strengthen the premunition of body.Strengthen feeding and management, elimination may reduce resistance against diseases factor and pathogenic inducement is as crowded in colony house, ventilation and lighting is poor, moist, catch cold.Colony house, environment are regularly sterilized.After new introduction pig quarantines one month, health can be gregarious.Carry out immunization campaign, be the important measures of this disease of prevention, regularly carry out planned inoculation every year.The swine plague vaccine of current production has swine plague inactivated vaccine, swine plague Inner Mongol is weak toadstool seedling, swine plague eo-630 live vaccine, swine plague ta53 live vaccine, swine plague c20 live vaccine five kinds, use, preserve and points for attention by specification.When there is this disease, sick pig should be isolated, block, tightly sterilize.With the pig on hurdle, promptly prevent with serum or with vaccine.Should isolate for treatment to distributing disease pig, sterilization pig house.To newly buy pig quarantine one month after the gregarious raising of change without exception.Treatment can adopt following medicine:
1, penicillin 80-240 ten thousand intramuscular injection, use 10% sulphadiazine 10-20 milliliters to inject with water 5-10 milliliters of intramuscular injection, 12 hours once, is used in conjunction 3 days simultaneously.
2, more than 45 kilograms pig 2500 milligrams, chloramphenicol, streptomysin 3000 milligrams, the 20 milliliters of intramuscular injection of 10% aminopyrine, 6 hours 1 time, be used in conjunction 2 times.
3, gentamicin 1-2 mg/kg body weight, tetracycline 7-15 mg/kg body weight, every day 2 times, until temperature decline.
Western medicine easily develops immunity to drugs, and Chinese medicine has no side effect, without the resistance to the action of a drug, its role is to, the qi and blood of conditioning engine body, smooth the liver and regulate the spleen, the metabolic function of adjustment body and immunologic function, again there is antivirus action, therefore body recovery is fast, does not recur more, be that many veterinarian concentrated one's attention on the problem studied in recent years by herbal control swine plague.The Chinese medicine developed at present is good not as Western medicine to the treatment curative effect of swine plague, therefore has report Western medicine and Chinese traditional medicine composition to be used, though it has the advantage of relative low price, effective speed is comparatively slow, just can make transference cure when medicine time is longer.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of feed being used for the treatment of swine plague and containing Chinese medicine additive, and have evident in efficacy to the treatment suffering from swine plague, treat both principal and secondary aspect of disease, cure rate is high, and side effect is little, the advantage that cost is low.
In order to realize foregoing invention object, the invention provides a kind of feed being used for the treatment of swine plague, it is characterized in that, described feed comprises following raw material: corn, dregs of beans, peanut meal, wheat bran, stone flour, fish meal, tapioca flour, Kelp Powder, vitamin E and Chinese medicine additive.
Described feed is preferably made up of the raw material of following parts by weight: corn 50-80 weight portion, dregs of beans 50-60 weight portion, peanut meal 30-50 weight portion, wheat bran 20-30 weight portion, stone flour 10-30 weight portion, fish meal 10-20 weight portion, tapioca flour 10-30 weight portion, Kelp Powder 20-40 weight portion, vitamin E 5-10 weight portion and Chinese medicine additive 5-18 weight portion.
Described feed is preferably made up of the raw material of following parts by weight: corn 75 weight portion, dregs of beans 55 weight portion, peanut meal 41 weight portion, wheat bran 26 weight portion, stone flour 19 weight portion, fish meal 15 weight portion, tapioca flour 21 weight portion, Kelp Powder 32 weight portion, vitamin E 7 weight portion and Chinese medicine additive 12 weight portion.
Described Chinese medicine additive comprises following bulk drug: subprostrate sophora, Lasiosphaera fenzlii, the coptis, cape jasmine, the root of large-flowered skullcap, pollen, the dried immature fruit of citron orange, rheum officinale, radix scrophulariae, felwort, akebi, the capsule of weeping forsythia, balloonflower root, the compound of glauber-salt and liquorice, the larva of a silkworm with batrytis, cup chrysanthemum, lepidium seed, perillaseed, fritillaria thunbergii, manyleaf meadowure rhizome and root, betel nut and birthwort.
Described Chinese medicine additive is preferably made up of the bulk drug of following parts by weight: subprostrate sophora 11 ~ 20 weight portion, Lasiosphaera fenzlii 11 ~ 25 weight portion, the coptis 11 ~ 45 weight portion, cape jasmine 10 ~ 16 weight portion, the root of large-flowered skullcap 10 ~ 16 weight portion, pollen 10 ~ 15 weight portion, the dried immature fruit of citron orange 10 ~ 15 weight portion, rheum officinale 10 ~ 16 weight portion, radix scrophulariae 10 ~ 20 weight portion, felwort 10 ~ 15 weight portion, akebi 10 ~ 15 weight portion, the capsule of weeping forsythia 10 ~ 20 weight portion, balloonflower root 10 ~ 15 weight portion, the compound of glauber-salt and liquorice 10 ~ 15 weight portion, the larva of a silkworm with batrytis 10 ~ 15 weight portion, cup chrysanthemum 10 ~ 15 weight portion, lepidium seed 10 ~ 15 weight portion, perillaseed 10 ~ 20 weight portion, fritillaria thunbergii 10 ~ 15 weight portion, manyleaf meadowure rhizome and root 10 ~ 15 weight portion, betel nut 10 ~ 15 weight portion and birthwort 10 ~ 15 weight portion.
Described Chinese medicine additive is preferably made up of the bulk drug of following parts by weight: subprostrate sophora 15 weight portion, Lasiosphaera fenzlii 18 weight portion, the coptis 29 weight portion, cape jasmine 13 weight portion, the root of large-flowered skullcap 13 weight portion, pollen 12 weight portion, the dried immature fruit of citron orange 12 weight portion, rheum officinale 13 weight portion, radix scrophulariae 15 weight portion, felwort 12 weight portion, akebi 13 weight portion, the capsule of weeping forsythia 15 weight portion, balloonflower root 13 weight portion, the compound of glauber-salt and liquorice 13 weight portion, the larva of a silkworm with batrytis 12 weight portion, cup chrysanthemum 12 weight portion, lepidium seed 13 weight portion, perillaseed 15 weight portion, fritillaria thunbergii 13 weight portion, manyleaf meadowure rhizome and root 12 weight portion, betel nut 12 weight portion and birthwort 13 weight portion.
Described Chinese medicine additive also comprises fibert, corn stigma, rue, rock wind and Radix Glycyrrhizae, described Chinese medicine additive is made up of the bulk drug of following ratio of weight and number: subprostrate sophora 15 ~ 20 weight portion, Lasiosphaera fenzlii 12 ~ 25 weight portion, the coptis 20 ~ 35 weight portion, cape jasmine 10 ~ 16 weight portion, the root of large-flowered skullcap 10 ~ 16 weight portion, pollen 10 ~ 15 weight portion, the dried immature fruit of citron orange 10 ~ 15 weight portion, rheum officinale 10 ~ 16 weight portion, radix scrophulariae 11 ~ 15 weight portion, felwort 11 ~ 15 weight portion, akebi 11 ~ 15 weight portion, the capsule of weeping forsythia 11 ~ 15 weight portion, balloonflower root 11 ~ 15 weight portion, the compound of glauber-salt and liquorice 10 ~ 15 weight portion, the larva of a silkworm with batrytis 10 ~ 15 weight portion, cup chrysanthemum 11 ~ 15 weight portion, lepidium seed 10 ~ 15 weight portion, perillaseed 11 ~ 18 weight portion, fritillaria thunbergii 11 ~ 15 weight portion, manyleaf meadowure rhizome and root 11 ~ 15 weight portion, betel nut 11 ~ 15 weight portion, birthwort 11 ~ 14 weight portion, fibert 11 ~ 14 weight portion, corn stigma 10 ~ 15 weight portion, rue 11 ~ 14 weight portion, rock wind 10 ~ 15 weight portion and Radix Glycyrrhizae 15 ~ 35 weight portion.
Described Chinese medicine additive is preferably made up of the bulk drug of following ratio of weight and number: subprostrate sophora 18 weight portion, Lasiosphaera fenzlii 19 weight portion, the coptis 32 weight portion, cape jasmine 13 weight portion, the root of large-flowered skullcap 13 weight portion, pollen 12 weight portion, the dried immature fruit of citron orange 12 weight portion, rheum officinale 13 weight portion, radix scrophulariae 13 weight portion, felwort 13 weight portion, akebi 12 weight portion, the capsule of weeping forsythia 13 weight portion, balloonflower root 13 weight portion, the compound of glauber-salt and liquorice 12 weight portion, the larva of a silkworm with batrytis 12 weight portion, cup chrysanthemum 13 weight portion, lepidium seed 13 weight portion, perillaseed 15 weight portion, fritillaria thunbergii 13 weight portion, manyleaf meadowure rhizome and root 13 weight portion, betel nut 13 weight portion, birthwort 12 weight portion, fibert 13 weight portion, corn stigma 12 weight portion, rue 13 weight portion, rock wind 13 weight portion and Radix Glycyrrhizae 25 weight portion.
The preparation method of described Chinese medicine additive comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials, after mixing, be ground into powder;
Second step, the first step obtained powder and add in cold water and soak 24 hours ~ 36 hours, with slow fire boiling, decocting time is 2 hours ~ 3 hours, decoction liquor is filtered, obtain the first filtrate, the quality of the water added is 3 ~ 5 times of the powder quality that the first step obtains;
3rd step, second step is filtered the filter residue obtained again add in cold water, with slow fire boiling 2 ~ 4 times, each to decoct 1 hour ~ 2 hours, filter and merge filtered fluid, obtaining the second filtrate, the quality of the water added and identical in second step;
4th step, the first filtrate and the second filtrate merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, dry cream is put into spray dryer dry, ensure that EAT is at 170 DEG C ~ 190 DEG C, leaving air temp 60 DEG C ~ 80 DEG C, be ground into 200 order ~ 400 orders subsequently, obtain Chinese medicine additive powder.
In order to better realize foregoing invention object, the invention provides a kind of described preparation method being used for the treatment of the feed of swine plague, described preparation method comprises the following steps:
Take all raw materials by ratio of weight and the number of copies, drop into pulverizer and pulverize, grinding particle size is 25-40 order;
Drop into granulator to granulate, pelleting temperature is 65-80 DEG C, makes its gelatinization degree reach 90%;
Drop into disintegrating machine and carry out fragmentation, particle size after cracking is 8-15 order.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: feed provided by the invention comprise based on clearing heat and detoxicating, ventilating the lung and resolving phlegm, be auxiliary Chinese medicine additive with tonneau throat, anti-inflammatory analgetic, Chinese medicine additive and other raw materials cooperatively interact, acting in conjunction, to the treatment of the pig suffering from swine plague have evident in efficacy, cure rate is high, side effect is little, not easily recur, advantage that cost is low.
Detailed description of the invention
According to clinical manifestation and course of disease process, the most acute, acute and chronic three types can be divided into.The most acute: not occur any symptom, sudden onset, dead rapidly.The course of disease slightly elder shows body temperature and is elevated to 41 ~ 42 DEG C, and appetite is absolutely useless, and expiratory dyspnea, rapidly, visual mucous membrane cyanosis, purplish-red macula appears in skin in heartbeat.Bottleneck throat and neck heating, red and swollen, hard, severe patient is extended down to the basal part of the ear, front.Sick pig breathes and is the devil, normal in sitting position of dog gesture, and extend neck, sometimes can send sound of stridulating, mouth and nose flow out white foam, sometimes with color.Once there is serious expiratory dyspnea, the state of an illness often worsens rapidly, very fast dead.Death rate Chang Gaoda 100%, spontaneous remission person is rare.Acute: this type is the most common.Body temperature is increased to 40 ~ 41 DEG C, and the initial stage is spastic dry cough, expiratory dyspnea, mouth and nose flow out foam, be sometimes mixed with blood, after become wet cough.With disease, breathe more difficult, often make sitting position of dog gesture, chest palpation has pain.Lassitude, poor appetite or absolutely useless, there is erythema in skin, later stage languishment, does not rise sleepingly, how because of death by suffocation.The course of disease 5 ~ 8 days, the dead does not transfer to chronic.Chronic type: main manifestations is pneumonia and chronic gastroenteritis.Time have persistent cough and expiratory dyspnea, have fluid resistance or purulence nose liquid a little.Arthroncus, often has diarrhoea, poor appetite, malnutritive, has scab sample eczema, grows and stops, skeletonize, the course of disease more than 2 weeks, and majority occurs dead.Chinese veterinarian thinks, swine plague is many catches a cold because feeding and management is bad and weather fusion is suffered from cold or suffers from other diseases, body healthy tendency is impaired, defend outer ability to reduce, disease and evil invades lung through mouth and nose and defends, and heat evaporates poison so that qi depression to blood stasis, then heat symptoms caused by an exopathgen upper punch throat, so that pharyngitis heat pain, convulsive seizure due to phlegm-fire is strongly fragrant in lung channel, impairment of dispersing and descending function of the lung and cause the circulation of vital energy in the wrong direction and cough and breathe heavily, have difficulty in breathing; Heat enters ying blood, then see skin erythema etc.Treatment swine plague disease should based on clearing heat and detoxicating, ventilating the lung and resolving phlegm, be auxiliary with tonneau throat, anti-inflammatory analgetic.
According to above-mentioned theory and principle, the invention provides a kind of feed being used for the treatment of swine plague, feed comprises Chinese medicine additive; Wherein, Chinese medicine additive comprises subprostrate sophora, Lasiosphaera fenzlii, the coptis, cape jasmine, the root of large-flowered skullcap, pollen, the dried immature fruit of citron orange, rheum officinale, radix scrophulariae, felwort, akebi, the capsule of weeping forsythia, balloonflower root, the compound of glauber-salt and liquorice, the larva of a silkworm with batrytis, cup chrysanthemum, lepidium seed, perillaseed, fritillaria thunbergii, manyleaf meadowure rhizome and root, betel nut and birthwort.
The pharmacological property of each raw material is as follows:
Subprostrate sophora: bitter, cold; Poisonous.Attach to the lung and stomach meridians.Function cures mainly: clearing heat and detoxicating, detumescence relieve sore throat.Pent up for fiery poison, abscess of throat, gingivitis.
Lasiosphaera fenzlii: pungent is flat.Function cures mainly: heat-clearing, relieve sore throat, hemostasis.Cure mainly: sphagitis, tonsillitis; Traumatism and bleeding is controlled in external application, hemorrhoid hemorrhage pernio.
The coptis: heat-clearing and damp-drying drug, purging intense heat and detonicating.Full for damp and hot ruffian, vomiting acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, blood-head tells nosebleed, hot eyes, and toothache, quenches one's thirst, and carbuncle swells furunculosis; Control eczema outward, wet sore, duct is suppurated.It is burning hot that prepared RHIZOMA COPTIDIS with vino is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For hot eyes, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach and stomach preventing or arresting vomiting.Tie mutually for fever and chills, damp and hot middle resistance, ruffian is completely vomitted.The cornel coptis is relaxed liver and stomach preventing or arresting vomiting.For liver-stomach disharmony, vomiting acid regurgitation.Damp and hot for endoretention of damp heat, stomach, vomit, rush down the diseases such as dysentery.Join the root of large-flowered skullcap, rheum officinale etc., the card of endoretention of damp heat can be controlled.Be reluctant to leave stomach to damp and hot, often coordinate the tuber of pinellia, caulis bambusae in taenian; Join the banksia rose, the root of large-flowered skullcap, the root of kudzu vine etc. and rush down dysentery to control.
Cape jasmine: bitter, cold in nature, enter the heart, lung, three burnt, have the effect of relieving restlessness purging intense heat, soothing liver-qi stagnation, clearing heat and promoting diuresis, cooling blood and hemostasis, be mainly used in the vexed uneasiness of the strongly fragrant chest gastral cavity of warm heat disease heat, bother not peaceful; Liver depression is not relaxed or Liver Channel has having a dizzy spell of heat, pain in chest and hypochondrium, hot eyes dry throat; Jaundice with damp-heat pathogen; The symptoms such as the abdominal distention of qi depression to blood stasis, the burnt heat conduction of cape jasmine tonneau three is descending, and has anti-hepatic lesion effect.
The root of large-flowered skullcap: have heat-clearing and damp-drying drug, cool blood is antiabortive, detoxicating functions.Cure mainly warm heat disease, the infection of the upper respiratory tract, cough with lung heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, carbuncle swell the diseases such as furuncle sore.The clinical practice of the root of large-flowered skullcap is antibacterial not worse than the coptis, and does not develop immunity to drugs.We are by the strong feature of broad-spectrum antibacterial action, are used in fungal culture miscellaneous bacteria and infect special severe, fine by root of large-flowered skullcap extract effect." Bencao Jingshu ": the root of large-flowered skullcap, its property is respectful clearly, so evil removing: bitter is so eliminating dampness; Cold sensation of the genitalia is so victory warm, therefore main all heat.All hot persons, heat symptoms caused by an exopathgen with all over heat also, jaundice, intestines are out-of-the-way, let out dysentery, and the disease of all damp and hot victory also, analyses it, then all diseases are from recover.Bitter cold can except damp and hot, thus small intestine profit and water from by, source is clearly then flowed also clean.The blood person of closing, real heat is at blood system, and instant heating human blood room, make us obstructed through closing, damp and hot solution, then Ying Qi clearly and voluntarily also.Dislike sore subcutaneous ulcer erosion person, blood-head then stays knot, and is that the carbuncle stain that swells is also rotten: fiery ulcer person, also, cool blood heat extraction, then self-healing also for internal heat blood trouble.
Pollen: sweet, micro-hardship, is slightly cold.Attach to the lung and stomach meridians.Clearing heat and promoting fluid, detumescence and apocenosis.For pyreticosis polydipsia, lung-heat type cough, interior heat is quenched one's thirst, sore swollen toxin." detailed outline ": radices trichosanthis, sweet and slightly bitter taste acid, acid can be promoted the production of body fluid, therefore profit of quenching the thirst is withered, and fire falls in micro-hardship, does not sweetly injure one's stomach, and former times people only says its bitter cold, like deeply not examining." book on Chinese herbal medicine converge with speech ": root of Chinese trichosanthes, it is hot and suffocating to move back the five internal organs, and as internal heat is contained and dry tongue and mouth, lung-fire is contained and the swollen larynx numbness of pharynx, and spleen fire is contained and dispute tooth swells, and convulsive seizure due to phlegm-fire is contained and cough is not peaceful.Walk note if the side of body of irascibility is swollen, the hectic fever due to yin dysphoria with smothery sensation of kidney fire, or ulcer is not burst, and hot poison does not fall apart, or five subcutaneous ulcer yellow skin and eyes, and if if the pouring of little water is puckery, be all intimately caused by pent-up, convulsive seizure due to phlegm-fire, falls in only this agent energy relieving stagnation, and can control it.Its property is sweet cold again, kindly can control thirsty, and control empty thirsty from tonic, control fire from the medicine of a cold nature thirsty, control yearningly strongly fragrant from gas medicine, controlling polydipsia from blood medicine, is control thirsty key medicine also.
The dried immature fruit of citron orange: bitter, pungent, sour, temperature.Return spleen, stomach warp.Function cures mainly: relieving stagnant Qi disappears long-pending, loose ruffian of reducing phlegm.Stop in stagnant, the full distending pain of ruffian, heavy after rushing down dysentery, suffer from constipation, the stagnant vapour lock obstruction of qi in the chest of phlegm, accumulation of pathogens in chest; Gastroptosis, prolapse of the anus, the prolapse of uterus.
Rheum officinale: cure mainly real hot constipation; The thermojunction feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhoea; Oedema abdomen is full; Difficult urination; Hot eyes; Abscess of throat; Aphthae; Gastropyretic vomiting; Spit blood; Spitting of blood; Bleeding from five sense organs or subcutaneous tissue; Have blood in stool; Hematuria; Store blood; Through closing; The stagnant stomachache of the stasis of blood in postpartum; A lump in the abdomen causing distension and pain; Traumatic injury; The malicious large carbuncle of heat; Erysipelas; Scald.
Radix scrophulariae: taste is sweet, bitter, salty; Cold nature.Return lung, stomach, kidney channel.Clearing heat and cooling blood, purging intense heat and detonicating, enriching yin.Temperature heresy is joined the army, and cave in pericardium, febrile virulent maculae, and the deep red polydipsia of consumption of YIN caused by febrile disease, tongue, Tianjin hinder constipation, hectic fever due to yin labor is coughed, hot eyes, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.There is clearing heat and cooling blood, removing toxic substances, dissipating bind relieve sore throat, effect of enriching yin.For: warm heat disease heat enters ying blood, the card of consumption of YIN caused by febrile disease.There is clearing heat and cooling blood, effect of removing toxic substances enriching yin.
Felwort: bitter, cold.Return liver, gallbladder channel.Function cures mainly: heat-clearing and damp-drying drug, purging the liver of pathogenic fire courage fire.For jaundice with damp-heat pathogen, swelling of vulva pruritus vulvae, under band, Qiang Zhong, eczema itch, hot eyes, deaf, hypochondriac pain, bitter taste, convulsion.
Akebi: bitter, be slightly cold.Enter the heart channel of Hang-Shaoyin, small intestinl channel, urinary bladder channel.There is the effect of clearing away the heart-fire, diuresis, lactogenesis of stimulating the menstrual flow.For irritable feverish sensation in chest, larynx numbness pharyngalgia, urinates red, and five drench, oedema, whole body contraction pain, few through closing breast.Heat drenches puckery pain, oedema.This product energy inducing diuresis for removing edema, lower dampness removing heat, makes that damp and hot heresy is descending discharges from urine.Treatment bladder damp-heat, scanty drak urine, drenches the puckery pain of drop, the normal and adapted such as plantain seed, talcum; For oedema, be then equipped with umbellate pore furgus, the equivalent use of the root bark of white mulberry.Aphthae, vexed urine is red.The fire of this product energy supernatant the heart channel of Hang-Shaoyin, under let out the heat of small intestine.Often control flaring up of heart fire, aphthae, or intestines and the disease such as the vexed urine that causes is red under heart-fire moving downward, the adapteds such as many and radix rehmanniae recen, Radix Glycyrrhizae, the leaf of bamboo.Few through closing breast.These product stimulate the menstrual flow lactogenesis.With controlling blood stasis through closing, join safflower, peach kernel, the equivalent use of the red sage root; If deficient or obstructed with controlling milk, can being equal to the seed of cowherb, pangolin and using; These product can also sharp blood vessels, get round by bribery, join ramulus mori, coix seed is equal to use, treatment damp-heat arthralgia pain.
The capsule of weeping forsythia: bitter, cold nature, enters the heart, liver, courage, small intestinl channel, have clearing heat and detoxicating, the effect of dispersing swelling and dissipating binds, for ulcer, scrofula, acute mastitis, erysipelas, anemopyretic cold, warm disease from the beginning of, warmly to join the army, high hot polydipsia, coma sends out spot, and heat drenches the treatment of the cards such as renal shutdown, has very strong inhibitory action to shigella dysenteriae, staphylococcus aureus.
Balloonflower root: bitter; Pungent; Property is put down.Return lung channel.Effect: a surname's lung, eliminate the phlegm, relieve sore throat, apocenosis, sharp the five internal organs, fill blood, mend the exhaustion or lesion of the five internal organs, foster the spirit of nobility.Cure mainly: coughing with a lot of sputum, abscess of throat, lung carbuncle pyemesis, fullness in the chest and hypochondriac pain, dysentery stomachache, aphthae, red eye, swell pain, uroschesis.For coughing with a lot of sputum, uncomfortable in chest not smooth, pharyngalgia, hoarsen, lung carbuncle pyemesis, sore purulence becomes not burst.Energy expelling phlegm and arresting coughing, and have a surname's lung, apocenosis effect.Contained platycodin is to the direct stimulation of oral cavity, throat, gastric mucosa, and reflectivity ground increases tunica mucosa bronchiorum hypersecretion thus sputum is diluted, and is easy to discharge; Balloonflower root has antitussive effect, and have and strengthen anti-inflammatory and immunization, its anti-inflammatory intensity is similar to aspirin; Water extract can strengthen the phagocytic function of macrophage, strengthens the sterilizing power of neutrocyte, improves lysozyme activity; Prevention effect is had to stress ulcer.The thick saponin(e of balloonflower root has calmness, analgesia, refrigeration function, again can hypoglycemic, norcholesterol, relaxing smooth muscle.Platycodin has very strong haemocylolysis, but oral can decomposition in alimentary canal destroys and lose haemocylolysis.
The compound of glauber-salt and liquorice: salty, bitter, cold.Return stomach, large intestine channel.Function cures mainly: purgating heat and bowels, moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat.For real hot constipation, dry feces, stagnant stomachache; Control abscess of throat outward, aphthae, swelling and aching of gum, hot eyes, carbuncle swells, erysipelas.
The larva of a silkworm with batrytis: taste is pungent; Salty; Property is put down.Return liver; Lung; Stomach warp.Function cures mainly: expelling wind and relieving convulsion; Reducing phlegm and resolving masses; Removing toxic substances relieve sore throat.Main epilepsy seizures; the air wai oblique eyes; prejudiced headache; sore throat; scrofula; mumps; rubella; sore.1. anticonvulsant action: 10% decocting liquid 2g/kg, to Mouse oral, has obvious antagonism to the convulsions that strychnine nitrate causes.The mixture (i.e. the decoction of five brave Chinese medicine Zhuifengsans) be made up of the commercially available larva of a silkworm with batrytis, cicada slough etc. can reduce strychnine, pentylenetetrazol, cocaine, and nicotine etc. cause the death toll of mice convulsion.Artificial larva of a silkworm with batrytis decoction also has the effect of the mice convulsion of antagonism caused by strychnine.2. syngignoscism: alcohol water-leach liquor has syngignoscism to mouse and rabbit, Mouse oral 0.5g/20g, hypodermic injection 0.25g/20g, approximate the hypodermic hypnosis effect of 50mg/kg phenobarbital.3. the pharmacological action of stiff pupa: the convulsions that stiff pupa antagonism small white mouse is caused by strychnine nitrate, effect is obvious, and result is consistent with the larva of a silkworm with batrytis.In the reduction death rate, test group and control group difference not obvious, but stiff pupa is consistent with the result of the larva of a silkworm with batrytis.In two results, stiff pupa is all slightly better than the larva of a silkworm with batrytis.In addition, stiff pupa still can suppress small white mouse S-180 (need affirm further), though have inhibitory action, DeGrain to staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa etc.Due to, stiff pupa convenient sources, therefore can in order to replace the larva of a silkworm with batrytis.4. the pharmacological research of silkworm king: the toxicity of silkworm king is very low.Immature male Mouse Weight is increased and has facilitation, obviously can increase prostate one sperm-storing bag of castration mouse and castrated rats, the weight of preputial gland, show that there is androgen-like action.
Cup chrysanthemum: clearing heat and detoxicating, anti-inflammation hemostasia, dehumidifying diuresis, desinsection.Cure mainly acute gastroenteritis, heatstroke, cystitis, urethritis, sphagitis, stomatitis, spit blood, bleeding from five sense organs or subcutaneous tissue.
Lepidium seed: pungent, bitter, Great Cold.Return lung, urinary bladder channel.Function cures mainly: removing heat from lung and relieving asthma, line water detumescence.Stop up lung for sputum, dyspnea and cough with excessive sputum, fullness in chest and hypochondrium, must not put down sleeping, and Pleural effusions swells, difficult urination; Cor pulmonale oedema.
Perillaseed: pungent, temperature.Return lung, large intestine channel.Function cures mainly: sending down abnormally ascending dissolving phlegm, relieving cough and asthma, relaxes bowel.The circulation of vital energy in the wrong direction is stopped up, cough and asthma, the dry constipation of intestines for phlegm.Pharmacological action: 1, to the effect of blood fat, feeds chicken with the feed containing perilla herb oil, chicken plasma cholesterol levels can be made to reduce, but act on without this mouse, and causes mouse neck to lose hair or feathers and skin lesion; Feed rabbit with the feed containing perilla herb oil, its body weight and liver weight can be increased, but the cholesterol level of blood plasma and liver is had no significant effect.2, bacteriostasis: experiment shows: the mould of perilla herb oil (0.1%) to proteus, black-koji mould, Penicillium notatum and occurring in nature all has inhibitory action. wherein to the effect obviously strong nipalgin of what 0.05% and the benzoic acid of 0.3% of yeast and mold.3, anticorrosion, antioxidation: the ethanol extract of perilla seed after degreasing has anticorrosion and antioxidation.The long storage periods of available what food and medicine. the BHT of its antioxidation compared with 0.02% (2,6-di-t-butyl p-Hydroxybenzylalcohol) is strong.
Fritillaria thunbergii: bitter, cold.Return lung, the heart channel of Hang-Shaoyin.Function cures mainly: heat-clearing dissipating bind, preventing phlegm from forming and stopping coughing, for wind-heat affecting lung, and phlegm-fire cough, lung carbuncle, acute mastitis, scrofula, sore.
Manyleaf meadowure rhizome and root: bitter, cold.Function cures mainly: heat-clearing and damp-drying drug, purging intense heat and detonicating.For enteritis, dysentery, jaundice, red eye, swell pain.
Betel nut: bitter; Pungent; Warm in nature.Return stomach; Large intestine channel.Effect, expelling parasite; Disappear long-pending; Lower gas; Row water; Preventing malaria.Malnutrition due to parasitic infestation; Eat stagnant; Abdominal distention; Heavy after rushing down dysentery; Beriberi; Oedema; Malaria.Resisting pathogenic microbes effect betel nut infusion (1:1) in vitro to trichophyton, permitted the dermatophyte such as blue achorion and had inhibitory action in various degree.Decoction and some strain of water logging agent infected by influenza A type have certain inhibitory action, and antiviral effect may be relevant with wherein contained tannin.
Birthwort: have clearing lung-heat sending down abnormally ascending, the effect that relieving cough and asthma, gut purge disappears hemorrhoid, its stem claims herba aristolochiae to have to regulate the flow of vital energy, clearing damp, promoting blood circulation and stopping pain effect, its root claims dutchmanspipe root to have effect of promoting qi circulation and relieving pain, removing toxicity for detumescence.
Chinese medicine additive of the present invention preferably also comprises: fibert, corn stigma, rue, rock wind and Radix Glycyrrhizae.
Fibert: sweet is flat.1. " Kaibao Bencao ": " taste is sweet, flat, nontoxic." 2. " medical center bun is wanted ": " is sweet salty, flat." function cures mainly: in tune, appetizing, improving eyesight.1. Cui Yu tin " cuisine canon ": " three worms are gone in the improving eyesight of food." 2. " Japan hanako materia medica ": " fertile white man, only hungry, in tune, appetizing." 3. " Kaibao Bencao ":, " main beneficial strength, wide stomach make us not hungry, hike."
Corn stigma: sweet, light is flat.Return bladder, liver, gallbladder channel.Function cures mainly: inducing diuresis to reduce edema, flat liver cholagogic.For acute and chronic ephritis, oedema, acute hepatitis, chronic hepatitis, hypertension, diabetes, chronic nasosinusitis, lithangiuria, Biliary Calculi, the disease such as difficult urination, damp and hot jaundice.And can habitual abortion be prevented.
Rue: pungent, micro-hardship is cool.Function cures mainly: clearing heat and detoxicating, blood stasis removing analgesic.For cold, fever, toothache, irregular menstruation, infantile eczema; Sore furuncle poison is controlled in external application, traumatic injury.
Rock wind: bitter; Cool.Function cures mainly: promoting diuresis for stranguria; Clearing heat and detoxicating.Main stranguria; Oedema; Acute mastitis; Sore
Radix Glycyrrhizae: property is put down, and taste is sweet, returns 12 warps.Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, the anxious pain of gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, cushion toxicity, strongly have removing toxic substances, eliminate the phlegm, pain relieving, spasmolysis so that the pharmacological action such as anticancer, Radix Glycyrrhizae has reducing blood lipid, oxidation resistant effect.
Embodiment 1 Chinese medicine additive 1
Embodiments provide a kind of Chinese medicine additive being used for the treatment of swine plague, Chinese medicine additive is made up of the raw material of following parts by weight: subprostrate sophora 15 weight portion, Lasiosphaera fenzlii 18 weight portion, the coptis 29 weight portion, cape jasmine 13 weight portion, the root of large-flowered skullcap 13 weight portion, pollen 12 weight portion, the dried immature fruit of citron orange 12 weight portion, rheum officinale 13 weight portion, radix scrophulariae 15 weight portion, felwort 12 weight portion, akebi 13 weight portion, the capsule of weeping forsythia 15 weight portion, balloonflower root 13 weight portion, the compound of glauber-salt and liquorice 13 weight portion, the larva of a silkworm with batrytis 12 weight portion, cup chrysanthemum 12 weight portion, lepidium seed 13 weight portion, perillaseed 15 weight portion, fritillaria thunbergii 13 weight portion, manyleaf meadowure rhizome and root 12 weight portion, betel nut 12 weight portion and birthwort 13 weight portion.
The preparation method of Chinese medicine additive comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials material, after mixing, be ground into powder;
Second step, the first step obtained powder and add in cold water and soak 36 hours, with slow fire boiling, decocting time is 2.5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 4 times of the powder quality that the first step obtains;
3rd step, second step is filtered the filter residue obtained again add in cold water, with slow fire boiling 3 times, each to decoct 1 hour, filter and merge filtered fluid, obtaining the second filtrate, the quality of the water added and identical in second step;
4th step, the first filtrate and the second filtrate merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, and ensure that EAT is at 180 DEG C, leaving air temp 70 DEG C, is ground into 300 orders subsequently, obtains Chinese medicine additive powder.
Embodiment 2 Chinese medicine additive 2
The embodiment of the present invention 2 provides a kind of Chinese medicine additive being used for the treatment of swine plague, Chinese medicine additive comprises the raw material of following parts by weight: subprostrate sophora 18 weight portion, Lasiosphaera fenzlii 19 weight portion, the coptis 32 weight portion, cape jasmine 13 weight portion, the root of large-flowered skullcap 13 weight portion, pollen 12 weight portion, the dried immature fruit of citron orange 12 weight portion, rheum officinale 13 weight portion, radix scrophulariae 13 weight portion, felwort 13 weight portion, akebi 12 weight portion, the capsule of weeping forsythia 13 weight portion, balloonflower root 13 weight portion, the compound of glauber-salt and liquorice 12 weight portion, the larva of a silkworm with batrytis 12 weight portion, cup chrysanthemum 13 weight portion, lepidium seed 13 weight portion, perillaseed 15 weight portion, fritillaria thunbergii 13 weight portion, manyleaf meadowure rhizome and root 13 weight portion, betel nut 13 weight portion, birthwort 12 weight portion, fibert 13 weight portion, corn stigma 12 weight portion, rue 13 weight portion, rock wind 13 weight portion and Radix Glycyrrhizae 25 weight portion.
The preparation method of Chinese medicine additive comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials material, after mixing, be ground into powder;
Second step, the first step obtained powder and add in cold water and soak 30 hours, with slow fire boiling, decocting time is 3 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 5 times of the powder quality that the first step obtains;
3rd step, second step is filtered the filter residue obtained again add in cold water, with slow fire boiling 2 times, each to decoct 2 hours, filter and merge filtered fluid, obtaining the second filtrate, the quality of the water added and identical in second step;
4th step, the first filtrate and the second filtrate merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, and ensure that EAT is at 190 DEG C, leaving air temp 80 DEG C, is ground into 400 orders subsequently, obtains Chinese medicine additive powder.
Embodiment 3 feed 1
Embodiments provide a kind of feed being used for the treatment of swine plague, be made up of the raw material of following parts by weight: corn 75 weight portion, dregs of beans 55 weight portion, peanut meal 41 weight portion, wheat bran 26 weight portion, stone flour 19 weight portion, fish meal 15 weight portion, tapioca flour 21 weight portion, Kelp Powder 32 weight portion, vitamin E 7 weight portion and Chinese medicine additive 12 weight portion.
Wherein, Chinese medicine additive is the Chinese medicine additive 1 of embodiment 1.
The preparation method of feed is as follows:
Take all raw materials by ratio of weight and the number of copies, drop into pulverizer and pulverize, grinding particle size is 30 orders;
Drop into granulator to granulate, pelleting temperature is 70 DEG C, makes its gelatinization degree reach 90%;
Drop into disintegrating machine and carry out fragmentation, particle size after cracking is 10 orders.
Embodiment 4 feed 2
Embodiments provide a kind of feed being used for the treatment of swine plague, be made up of the raw material of following parts by weight: corn 50 weight portion, dregs of beans 50 weight portion, peanut meal 50 weight portion, wheat bran 20 weight portion, stone flour 23 weight portion, fish meal 10 weight portion, tapioca flour 30 weight portion, Kelp Powder 40 weight portion, vitamin E 5 weight portion and Chinese medicine additive 7 weight portion.
Wherein, Chinese medicine additive is the Chinese medicine additive 2 of embodiment 2.
The preparation method of feed is as follows:
Take all raw materials by ratio of weight and the number of copies, drop into pulverizer and pulverize, grinding particle size is 40 orders;
Drop into granulator to granulate, pelleting temperature is 80 DEG C, makes its gelatinization degree reach 90%;
Drop into disintegrating machine and carry out fragmentation, particle size after cracking is 15 orders.
Acute toxicity test
Application NIH mouse 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mouse is divided into two groups at random, often organizes 20, i.e. control group and administration group, fasting 12 hours before experiment; Chinese medicine additive prepared by embodiments of the invention 1 is dissolved in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32.9 crude drugs/kg), control group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mouse toxic reaction and death toll.Experimental result shows: compare with control group, and after administration, mouse has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>32.9 crude drug/kg of the present invention, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.073g crude drug/kg/ day.By batheroom scale: the dosis tolerata of mouse (average weight is in 20g) oral administration gavage Chinese medicine of the present invention is 901 times of quantity.Therefore the acute toxicity of the embodiment of the present invention 1 Chinese medicine additive is low, clinical drug safety.With the test method that the Chinese medicine additive of the embodiment of the present invention 2 is identical for object adopts, result proves that the acute toxicity of embodiment 2 Chinese medicine additive is low equally, clinical drug safety.
Long term toxicity test
The embodiment of the present invention 1 Chinese medicine additive presses 10.78,20.35 and 33.48g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mouse, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, stool and urine, body weight, organ weights, blood picture, hepatic and renal function, blood sugar, blood fat of Chinese medicine additive to mouse of the embodiment of the present invention 1 all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that the Chinese medicine additive of the embodiment of the present invention 1 is little to toxicity after mouse long-term prescription, also there is no difference reaction after drug withdrawal, application safety.With the test method that the Chinese medicine additive of the embodiment of the present invention 2 is identical for object adopts, result proves that the Chinese medicine additive of embodiment 2 is little to toxicity after mouse long-term prescription equally, does not also have difference reaction, application safety after drug withdrawal.
Clinical testing
1.1 for examination material
1.1.1 for examination animal
In 225 the healthy growing and fattening pigs of pig farm, Qingdao, Shandong Province random selecting, as experiment pig.
1.1.2 for prelibation strain
Pig Pasteurella C44-41 and standard thereof resist clear, are provided by China Veterinary Drugs Supervisory Inst., cultivate voluntarily before infecting with broth bouillon.
1.1.3 reagent thing or feed is supplied
Chinese medicine additive 1 prepared by embodiment 1, is mixed in feed according to the 5-10% of feed gross weight; Chinese medicine additive 2 prepared by embodiment 2, is mixed in feed according to the 5-10% of feed gross weight; Feed 1 prepared by embodiment 3, feeds according to normal feed mode; Feed 2 prepared by embodiment 4, feeds according to normal feed mode; Penicillin 80-240 ten thousand+10% sulphadiazine parenteral solution.
1.2 test method
1.2.1 inoculation test
Inject after cultured pig Pasteurella C44-41 meat soup respectively ear, infective dose is 12.6 bacterium/kg.w.Infect in latter five days and have 220 pigs to occur swine plague symptom, select 180 ill pigs as experiment pig.
1.2.2 grouping is tested
300 ill piglets are divided into three groups at random, often organize 60, i.e. embodiment group 1, embodiment group 2, embodiment group 3, embodiment group 4 and control group.
1.2.3 test method
Occur after infection that the pig of swine plague adopts different methods of treatments respectively, wherein, embodiment group 1 uses the embodiment of the present invention 1 Chinese medicine additive to treat, Chinese medicine additive 1 is mixed in feed, conventionally feed, each mixed volume is the 5-10% of feed gross weight, uses three days continuously; Embodiment group 2 uses the embodiment of the present invention 2 Chinese medicine additive to treat, and is mixed into by Chinese medicine additive in feed, conventionally feeds, and each mixed volume is the 5-10% of feed gross weight, uses three days continuously; The feed 1 that embodiment group 3 uses embodiment 3 to prepare, feeds according to normal feed mode; The feed 2 that embodiment group 4 uses embodiment 4 to prepare, feeds according to normal feed mode; Control group uses penicillin 80-240 ten thousand intramuscular injection, and inject with the intramuscular injection of water 5-10 milliliter with 10% sulphadiazine 10-20 milliliter, 12 hours once, is used in conjunction 3 days simultaneously.
1.2.4 observed and recorded
Attack rear clinical symptoms and the pathological change observing each group of ill pig of poison, and compare its order of severity, record death toll after infecting, within three days, treat the result for the treatment of after terminating.
2 results
2.1 criterion of therapeutical effect
Cure: ill temperature of pig body, body colour, breathing, appetite all recover normal, cough, diarrhoea, oedema phenomenon disappear;
Effective: ill temperature of pig body, body colour, breathing, appetite progressively recover normal, cough, diarrhoea, oedema alleviate;
Invalid: ill pig symptom is not alleviated, and even increases the weight of death.
2.2 observed results are as shown in table 1.
Data from table 1: compared with control group, the Chinese medicine additive of the embodiment of the present invention 1 and embodiment 2 and the treatment of feed to swine plague of embodiment 3 and embodiment 4 have evident in efficacy, side effect is low, the advantage that treated effect is high, and the result for the treatment of of feed 3 and feed 4 is better than Chinese medicine additive 1 and Chinese medicine additive 2; Find in long-term observation subsequently, embodiment group 1, embodiment group 2, embodiment group 3 and embodiment group 4 cure pig again the incidence of disease be starkly lower than the pig of control group.
2.3 attack the rear symptom of poison and cut open inspection result
After attacking poison, the symptom of ill pig is: body temperature is elevated to more than 41 DEG C, and poor appetite or absolutely useless, expiratory dyspnea, purplish-red macula appears in skin.Dead sick pig after infection is dissected, finds that whole body mucous membrane, serous coat and hypodermis have blutpunkte, larynx and surrounding tissue hemorrhagic oedema thereof, swollen lymph node, gastrointestinal mucosa hemorrhagic inflammation, indivedual pig lungs You Ganbian district, and have yellow or grey necrosis region.
Concrete case
Case 1
Certain raiser raises growing and fattening pigs 121 altogether, and November in 2012,1 growing and fattening pigs sudden onset was dead, and other pigs all have swine plague symptom in various degree, expiratory dyspnea, neck oedema, and purple erythema appears in skin.Dead pig dissected and find that there is blutpunkte in dead pigskin undertissue, larynx and surrounding tissue hemorrhagic oedema thereof, gastric bleeding is red and swollen, is diagnosed as swinery and suffers from swine plague.The embodiment of the present invention 1 Chinese medicine additive 1 is used to treat, Chinese medicine additive is mixed in feed, conventionally feed, each mixed volume is 8% of feed gross weight, continuous use is after three days, 163 ill pigs recover normal, and 37 ill pigs continue to feed and add the feed two days of Chinese medicine additive 1, also all recover normal.
Case 2
Certain self-employed worker that raises pigs feeds growing and fattening pigs 10, because pigsty is moist, heat, impels germ to spread rapidly, 10 pigs are caused to occur that body temperature is elevated to more than 41 DEG C, poor appetite or absolutely useless, expiratory dyspnea, there is the symptom such as purplish-red macula, neck oedema in skin, is diagnosed as swine plague.Use the embodiment of the present invention 2 Chinese medicine additive 2 to treat, be mixed into by Chinese medicine additive in feed, conventionally feed, each mixed volume is 6% of feed gross weight, and after using three days continuously, 10 ill pigs all recover normal.
Case 3
Zhengzhou, henan pig farm finds the phenomenon of pig sudden death, immediately 103 ill pigs are chosen isolated rearing, the ill temperature of pig body of the overwhelming majority is elevated to more than 41 DEG C, poor appetite or absolutely useless, expiratory dyspnea, there is the symptom such as purplish-red macula, neck oedema in skin, dead pig is dissected, finds that there is blutpunkte in dead pigskin undertissue, larynx and surrounding tissue hemorrhagic oedema thereof, gastric bleeding is red and swollen, is diagnosed as swinery and suffers from swine plague.Ill pig fed by the use embodiment of the present invention 4 feed 2 conveniently feed mode, and after using three days continuously, 100 ill pigs all recover normal, and the ill pig in two continues to use feed 2 to feed one day in addition, and also recovery is normal.
Case 4
The 60 bull piglets that certain raiser raises, July in 2012, three piglets did not eat food, expiratory dyspnea, and dead after one day, swine plague symptom in various degree appears in other piglet subsequently, expiratory dyspnea, and purple erythema appears in skin.Dissected by dead piglet and find that hypodermis has blutpunkte, larynx hemorrhagic oedema, is diagnosed as swine plague.Ill piglet fed by the use embodiment of the present invention 3 feed 1 conveniently feed mode, and after using three days continuously, 58 ill pigs recover normal, and the ill pig continuation in two uses feed 2 to feed two days in addition, also recovers normal.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (7)
1. be used for the treatment of the feed of swine plague, it is characterized in that, described feed is made up of the raw material of following parts by weight: corn 50-80 weight portion, dregs of beans 50-60 weight portion, peanut meal 30-50 weight portion, wheat bran 20-30 weight portion, stone flour 10-30 weight portion, fish meal 10-20 weight portion, tapioca flour 10-30 weight portion, Kelp Powder 20-40 weight portion, vitamin E 5-10 weight portion and Chinese medicine additive 5-18 weight portion;
Described Chinese medicine additive is made up of the bulk drug of following parts by weight: subprostrate sophora 11 ~ 20 weight portion, Lasiosphaera fenzlii 11 ~ 25 weight portion, the coptis 11 ~ 45 weight portion, cape jasmine 10 ~ 16 weight portion, the root of large-flowered skullcap 10 ~ 16 weight portion, pollen 10 ~ 15 weight portion, the dried immature fruit of citron orange 10 ~ 15 weight portion, rheum officinale 10 ~ 16 weight portion, radix scrophulariae 10 ~ 20 weight portion, felwort 10 ~ 15 weight portion, akebi 10 ~ 15 weight portion, the capsule of weeping forsythia 10 ~ 20 weight portion, balloonflower root 10 ~ 15 weight portion, the compound of glauber-salt and liquorice 10 ~ 15 weight portion, the larva of a silkworm with batrytis 10 ~ 15 weight portion, cup chrysanthemum 10 ~ 15 weight portion, lepidium seed 10 ~ 15 weight portion, perillaseed 10 ~ 20 weight portion, fritillaria thunbergii 10 ~ 15 weight portion, manyleaf meadowure rhizome and root 10 ~ 15 weight portion, betel nut 10 ~ 15 weight portion and birthwort 10 ~ 15 weight portion.
2. the feed being used for the treatment of swine plague according to claim 1, it is characterized in that, described feed is made up of the raw material of following parts by weight: corn 75 weight portion, dregs of beans 55 weight portion, peanut meal 41 weight portion, wheat bran 26 weight portion, stone flour 19 weight portion, fish meal 15 weight portion, tapioca flour 21 weight portion, Kelp Powder 32 weight portion, vitamin E 7 weight portion and Chinese medicine additive 12 weight portion.
3. the feed being used for the treatment of swine plague according to claim 1, it is characterized in that, described Chinese medicine additive is made up of the bulk drug of following parts by weight: subprostrate sophora 15 weight portion, Lasiosphaera fenzlii 18 weight portion, the coptis 29 weight portion, cape jasmine 13 weight portion, the root of large-flowered skullcap 13 weight portion, pollen 12 weight portion, the dried immature fruit of citron orange 12 weight portion, rheum officinale 13 weight portion, radix scrophulariae 15 weight portion, felwort 12 weight portion, akebi 13 weight portion, the capsule of weeping forsythia 15 weight portion, balloonflower root 13 weight portion, the compound of glauber-salt and liquorice 13 weight portion, the larva of a silkworm with batrytis 12 weight portion, cup chrysanthemum 12 weight portion, lepidium seed 13 weight portion, perillaseed 15 weight portion, fritillaria thunbergii 13 weight portion, manyleaf meadowure rhizome and root 12 weight portion, betel nut 12 weight portion and birthwort 13 weight portion.
4. the feed being used for the treatment of swine plague according to claim 1, is characterized in that, described Chinese medicine additive also comprises fibert, corn stigma, rue, rock wind and Radix Glycyrrhizae, described Chinese medicine additive is made up of the bulk drug of following ratio of weight and number: subprostrate sophora 15 ~ 20 weight portion, Lasiosphaera fenzlii 12 ~ 25 weight portion, the coptis 20 ~ 35 weight portion, cape jasmine 10 ~ 16 weight portion, the root of large-flowered skullcap 10 ~ 16 weight portion, pollen 10 ~ 15 weight portion, the dried immature fruit of citron orange 10 ~ 15 weight portion, rheum officinale 10 ~ 16 weight portion, radix scrophulariae 11 ~ 15 weight portion, felwort 11 ~ 15 weight portion, akebi 11 ~ 15 weight portion, the capsule of weeping forsythia 11 ~ 15 weight portion, balloonflower root 11 ~ 15 weight portion, the compound of glauber-salt and liquorice 10 ~ 15 weight portion, the larva of a silkworm with batrytis 10 ~ 15 weight portion, cup chrysanthemum 11 ~ 15 weight portion, lepidium seed 10 ~ 15 weight portion, perillaseed 11 ~ 18 weight portion, fritillaria thunbergii 11 ~ 15 weight portion, manyleaf meadowure rhizome and root 11 ~ 15 weight portion, betel nut 11 ~ 15 weight portion, birthwort 11 ~ 14 weight portion, fibert 11 ~ 14 weight portion, corn stigma 10 ~ 15 weight portion, rue 11 ~ 14 weight portion, rock wind 10 ~ 15 weight portion and Radix Glycyrrhizae 15 ~ 35 weight portion.
5. the feed being used for the treatment of swine plague according to claim 4, it is characterized in that, described Chinese medicine additive is made up of the bulk drug of following ratio of weight and number: subprostrate sophora 18 weight portion, Lasiosphaera fenzlii 19 weight portion, the coptis 32 weight portion, cape jasmine 13 weight portion, the root of large-flowered skullcap 13 weight portion, pollen 12 weight portion, the dried immature fruit of citron orange 12 weight portion, rheum officinale 13 weight portion, radix scrophulariae 13 weight portion, felwort 13 weight portion, akebi 12 weight portion, the capsule of weeping forsythia 13 weight portion, balloonflower root 13 weight portion, the compound of glauber-salt and liquorice 12 weight portion, the larva of a silkworm with batrytis 12 weight portion, cup chrysanthemum 13 weight portion, lepidium seed 13 weight portion, perillaseed 15 weight portion, fritillaria thunbergii 13 weight portion, manyleaf meadowure rhizome and root 13 weight portion, betel nut 13 weight portion, birthwort 12 weight portion, fibert 13 weight portion, corn stigma 12 weight portion, rue 13 weight portion, rock wind 13 weight portion and Radix Glycyrrhizae 25 weight portion.
6. the feed being used for the treatment of swine plague according to any one of claim 1-5, is characterized in that, the preparation method of described Chinese medicine additive comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials, after mixing, be ground into powder;
Second step, the first step obtained powder and add in cold water and soak 24 hours ~ 36 hours, with slow fire boiling, decocting time is 2 hours ~ 3 hours, decoction liquor is filtered, obtain the first filtrate, the quality of the water added is 3 ~ 5 times of the powder quality that the first step obtains;
3rd step, second step is filtered the filter residue obtained again add in cold water, with slow fire boiling 2 ~ 4 times, each to decoct 1 hour ~ 2 hours, filter and merge filtered fluid, obtaining the second filtrate, the quality of the water added and identical in second step;
4th step, the first filtrate and the second filtrate merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, dry cream is put into spray dryer dry, ensure that EAT is at 170 DEG C ~ 190 DEG C, leaving air temp 60 DEG C ~ 80 DEG C, be ground into 200 order ~ 400 orders subsequently, obtain Chinese medicine additive powder.
7. the preparation method being used for the treatment of the feed of swine plague as described in any one of claim 1-6, is characterized in that, described preparation method comprises the following steps:
Take all raw materials by ratio of weight and the number of copies, drop into pulverizer and pulverize, grinding particle size is 25-40 order;
Drop into granulator to granulate, pelleting temperature is 65-80 DEG C, makes its gelatinization degree reach 90%;
Drop into disintegrating machine and carry out fragmentation, particle size after cracking is 8-15 order.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103918947B (en) * | 2014-05-07 | 2015-07-08 | 娄志 | Prophylactic pig feed |
| CN104115993A (en) * | 2014-05-30 | 2014-10-29 | 安徽省正大源饲料集团有限公司 | Animal feed capable of preventing respiratory diseases of animals |
| CN104187152A (en) * | 2014-08-29 | 2014-12-10 | 广西富来康饲料有限公司 | Pig feed and preparation method thereof |
| CN104855738A (en) * | 2015-06-11 | 2015-08-26 | 山东新希望六和集团有限公司 | Compound feed for pig and preparation method of compound feed |
| CN106306466A (en) * | 2016-08-18 | 2017-01-11 | 广西丰兄农业开发有限公司 | Feed for treating swine plague and manufacture method thereof |
| CN106212957A (en) * | 2016-08-29 | 2016-12-14 | 广西大学 | A kind of Chinese medicine feed additive preventing and treating pig bacterial disease and preparation method thereof |
| CN106472836A (en) * | 2016-09-30 | 2017-03-08 | 安徽华澳生物技术有限公司 | A kind of feed additive of preventing and treating pig lung plague |
| CN106578374A (en) * | 2016-11-29 | 2017-04-26 | 南宁学院 | Xiang miniature pig feed additive having effect of preventing pig swine plague |
| CN108142683A (en) * | 2016-12-03 | 2018-06-12 | 灵丘县动物疫病预防控制中心 | A kind of swine plague epidemic-prevention fodder and preparation method |
| CN108813186A (en) * | 2018-07-03 | 2018-11-16 | 成都远大牧业发展有限公司 | A kind of pannage formula |
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| CN1947547A (en) * | 2006-09-18 | 2007-04-18 | 阜新红日牧业有限公司 | Health-care forage for pigs in stage of fattening |
| CN102987150A (en) * | 2012-12-06 | 2013-03-27 | 天津市永胜畜禽养殖专业合作社 | Nutritional and healthcare disease-resistant pig feed |
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| CN1947547A (en) * | 2006-09-18 | 2007-04-18 | 阜新红日牧业有限公司 | Health-care forage for pigs in stage of fattening |
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Address after: 253211 Guozhai Forest Farm, Suliuzhuang Town, Xiajin County, Dezhou City, Shandong Province (5F, Qingwo Pioneer Park Office Building, Xiajin Economic Development Zone) Patentee after: XIAJIN NEW HOPE LIUHE AGRICULTURE AND ANIMAL HUSBANDRY Co.,Ltd. Address before: 253211 Guozhai forest farm, suliuzhuang Town, Xiajin County, Dezhou City, Shandong Province Patentee before: XIAJIN NEW HOPE LIUHE AGRICULTURE AND ANIMAL HUSBANDRY Co.,Ltd. |
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