CN104068279B - A kind of eel feed containing Chinese medicine additive and preparation method thereof - Google Patents

A kind of eel feed containing Chinese medicine additive and preparation method thereof Download PDF

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Publication number
CN104068279B
CN104068279B CN201410327620.6A CN201410327620A CN104068279B CN 104068279 B CN104068279 B CN 104068279B CN 201410327620 A CN201410327620 A CN 201410327620A CN 104068279 B CN104068279 B CN 104068279B
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chinese medicine
medicine additive
eel
blood
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CN104068279A (en
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郝智慧
杨志强
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Lanzhou Institute of Animal Husbandry and Veterinary Medicine CAAS
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Lanzhou Institute of Animal Husbandry and Veterinary Medicine CAAS
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/80Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
    • Y02A40/81Aquaculture, e.g. of fish
    • Y02A40/818Alternative feeds for fish, e.g. in aquacultures

Abstract

The invention discloses a kind of eel compound feed and preparation method thereof, its feed comprises that expanded soybean, wheat, dried silkworm chrysalis, earthworm are dry, SDPP, bone meal, nano montmorillonite, propolis, corn oil, Choline Chloride, vitamin premix, microelement pre-mix material, complex enzyme formulation and Chinese medicine additive; Its preparation method comprises the following steps: pulverising step, blend step, ultramicro grinding step, granulation step, spraying process.The invention has the beneficial effects as follows: feed of the present invention contains with clearing heat and detoxicating, and cooling blood and hemostasis is the Chinese medicine additive of primary treatment principle, based on theory of traditional Chinese medical science, from entirety, control combines, and effective dispeling disease and evil, reaches good clinical therapeutic efficacy; Chinese medicine additive and other raw materials cooperatively interact, not only can treat eel Hemorrhagic open-mouth disease, improve the disease-resistant evil ability of defence of body, the production performance of eel can also be improved, consumer plays good health-care effect after eating this type of eel, improves the economic benefit of culturist.

Description

A kind of eel feed containing Chinese medicine additive and preparation method thereof
Technical field
The present invention relates to the animal-breeding feed containing deriving from plant, animal or raw mineral materials, particularly a kind of eel compound feed and preparation method thereof.
Background technology
Eel is that property straddling fish stocks in river fall in one, originates in marine, grows up in river to fresh water of tracing back, after get back to marine laying eggs.In annual spring, large quantities of elver (also claiming white young, eel line) enters rivers mouth from sea in groups.It is traditional famous and precious fish, is also one of the most mysterious in the world fish.Its growth course is very peculiar, seedling of laying eggs in the seawater before this, after enter again fresh water grow up.Eel still can survive after a year and a half " going on a hunger strike ", and the eel life-span of cultivation is 50 years.
The cause of disease of eel Hemorrhagic open-mouth disease is a kind of DNA type virus.Eel Hemorrhagic open-mouth disease has Case report in China Fujian, Guangdong.Eel more than main harm 1 full age.5 ~ October is morbidity season, and onset peak is 7 ~ August, and the death rate can reach 90%.
Ill eel shows as severe haemorrhage, and mainly cranial cavity is hemorrhage, is secondly that oral cavity and muscle of head are hemorrhage.Sick fish osteoporosis, easily osteomiosis occurring, there is blank in cranial cavity; Junction between dentary and ossa articularia gets loose, and oral cavity is often opened, and can not close.Liver,spleen,kidney enlargement, extremely anaemia.Ultra-thin section observation is carried out to sick eel blood, can virion be seen in haemocyte.
Histopathologic change: liver,kidney,spleen is dirty to be organized in hemorrhage, cell degeneration, sclerotin has the pathological change of a large amount of leukocyte infiltration, liver,kidney,spleen dirty cell ultrastructure obvious, there is nuclear chromatin limit collection, unusual forming core, a large amount of myelin figure in kidney, spleen hematopoietic tissue and PBC, autophagosome and autophagy lysosome etc., and in visible similar apoptotic cell and apoptotic body structure and adjacent cells, phagosome increases phenomenon.
Western medical treatment eel Hemorrhagic open-mouth disease there is no effectively preventing method at present, and mainly on the basis of comprehensive prevention, full pond float bactericide, in case bacteriological infection and increase the weight of the state of an illness.A large amount of ill eel brings huge economic loss to culturist, a kind of medicine effectively can treating eel Hemorrhagic open-mouth disease of market in urgent need, or feed is to meet the demand in market, effectively control eel Hemorrhagic open-mouth disease, at utmost reduces risk and the economic loss of eel culture.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of eel compound feed, this feed comprises and has Chinese medicine additive that is clearing heat and detoxicating, cooling blood and hemostasis effect, can prevent and treat eel Hemorrhagic open-mouth disease, adopt natural Chinese traditional medicines material, toxic and side effect is low, drug residue free, not only can disease therapy, the disease-resistant evil ability of defence of body can also be improved, after consumer eats this type of eel, can also immunity of organisms be improved, play good health-care effect, improve the economic benefit of culturist.
In order to realize foregoing invention object, the invention provides a kind of eel compound feed, described feed comprises that expanded soybean, wheat, dried silkworm chrysalis, earthworm are dry, SDPP, bone meal, nano montmorillonite, propolis, corn oil, Choline Chloride, vitamin premix, microelement pre-mix material, complex enzyme formulation and Chinese medicine additive.
In described feed, the parts by weight of each raw material are: expanded soybean 15-21 weight portion, wheat 16-25 weight portion, dried silkworm chrysalis 21-29 weight portion, earthworm does 24-29 weight portion, SDPP 3-7 weight portion, bone meal 5-8 weight portion, nano montmorillonite 2-6 weight portion, propolis 5-10 weight portion, corn oil 1-4 weight portion, Choline Chloride 0.3-1.5 weight portion, vitamin premix 0.05-0.1 weight portion, microelement pre-mix material 0.05-0.12 weight portion, complex enzyme formulation 1-3 weight portion and Chinese medicine additive 2-5 weight portion.
In described feed, the parts by weight of each raw material are preferably: expanded soybean 17 weight portion, wheat 21 weight portion, dried silkworm chrysalis 26 weight portion, earthworm dry 27 weight portions, SDPP 5 weight portion, bone meal 6 weight portion, nano montmorillonite 4 weight portion, propolis 7 weight portion, corn oil 2 weight portion, Choline Chloride 0.5 weight portion, vitamin premix 0.08 weight portion, microelement pre-mix material 0.08 weight portion, complex enzyme formulation 2 weight portion and Chinese medicine additive 3 weight portion.
Described Chinese medicine additive comprises following raw medicinal material: schizonepeta, dandelion, scouring rush, the root of large-flowered skullcap, cordate houttuynia, Herba Andrographitis, Lasiosphaera fenzlii, moutan bark, sweet wormwood, the root bark of Chinese wolf-berry, wolf's milk, tinosporae, field thistle, cape jasmine, cacumen biotae, hairyvein agrimony, radix boehmeriae, cogongrass rhizome, reed rhizome, madder, justicia, narrowleaf falsepimpernel herb, Chinese torreyanut and common maidenhair spleenwort herb with root.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are: schizonepeta 10-20 weight portion, dandelion 15-25 weight portion, scouring rush 10-20 weight portion, root of large-flowered skullcap 12-17 weight portion, cordate houttuynia 17-25 weight portion, Herba Andrographitis 10-17 weight portion, Lasiosphaera fenzlii 10-14 weight portion, moutan bark 14-20 weight portion, sweet wormwood 10-15 weight portion, root bark of Chinese wolf-berry 14-20 weight portion, wolf's milk 10-16 weight portion, tinosporae 13-19 weight portion, field thistle 12-17 weight portion, cape jasmine 10-15 weight portion, cacumen biotae 15-20 weight portion, hairyvein agrimony 10-15 weight portion, radix boehmeriae 15-22 weight portion, cogongrass rhizome 13-17 weight portion, reed rhizome 15-20 weight portion, madder 10-16 weight portion, justicia 13-20 weight portion, narrowleaf falsepimpernel herb 12-24 weight portion, Chinese torreyanut 14-20 weight portion and common maidenhair spleenwort herb with root 15-20 weight portion.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are preferably: schizonepeta 15 weight portion, dandelion 19 weight portion, scouring rush 15 weight portion, the root of large-flowered skullcap 15 weight portion, cordate houttuynia 20 weight portion, Herba Andrographitis 14 weight portion, Lasiosphaera fenzlii 12 weight portion, moutan bark 17 weight portion, sweet wormwood 12 weight portion, the root bark of Chinese wolf-berry 17 weight portion, wolf's milk 13 weight portion, tinosporae 17 weight portion, field thistle 14 weight portion, cape jasmine 12 weight portion, cacumen biotae 18 weight portion, hairyvein agrimony 12 weight portion, radix boehmeriae 18 weight portion, cogongrass rhizome 15 weight portion, reed rhizome 17 weight portion, madder 13 weight portion, justicia 17 weight portion, narrowleaf falsepimpernel herb 17 weight portion, Chinese torreyanut 18 weight portion and common maidenhair spleenwort herb with root 18 weight portion.
The preparation method of described Chinese medicine additive comprises the following steps:
The first step, mixes in proportion by described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, adds hot reflux 1 ~ 3 hour, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 1 ~ 2 times to be again the ethanol of 85 ~ 95%, to add hot reflux 1 ~ 3 hour that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders, obtain Chinese medicine additive powder.
Wherein, described complex enzyme formulation comprises one or more in amylase, protease, cellulase, 1,4 beta-glucanase, pectase and phytase.
In order to better realize foregoing invention object, present invention also offers a kind of preparation method of eel compound feed, described preparation method comprises the following steps:
Pulverising step: take that expanded soybean, wheat, dried silkworm chrysalis, earthworm are dry, bone meal, nano montmorillonite and propolis by weight percentage, drops into pulverizer and pulverizes;
Blend step: by weight percentage by after SDPP, corn oil, Choline Chloride, vitamin premix, microelement pre-mix material and Chinese medicine additive premixed, more fully mix with the comminuting matter obtained in pulverising step;
Ultramicro grinding step: drop into pulverizer and carry out ultramicro grinding;
Granulation step: drop into granulator, granulates, makes its gelatinization degree reach 90% at 70-80 DEG C;
Spraying process: the surface by weight complex enzyme formulation being sprayed to pellet.
Present invention also offers a kind of eel compound feed Chinese medicine additive, described Chinese medicine additive has following raw medicinal material to make: schizonepeta 10-20 weight portion, dandelion 15-25 weight portion, scouring rush 10-20 weight portion, root of large-flowered skullcap 12-17 weight portion, cordate houttuynia 17-25 weight portion, Herba Andrographitis 10-17 weight portion, Lasiosphaera fenzlii 10-14 weight portion, moutan bark 14-20 weight portion, sweet wormwood 10-15 weight portion, root bark of Chinese wolf-berry 14-20 weight portion, wolf's milk 10-16 weight portion, tinosporae 13-19 weight portion, field thistle 12-17 weight portion, cape jasmine 10-15 weight portion, cacumen biotae 15-20 weight portion, hairyvein agrimony 10-15 weight portion, radix boehmeriae 15-22 weight portion, cogongrass rhizome 13-17 weight portion, reed rhizome 15-20 weight portion, madder 10-16 weight portion, justicia 13-20 weight portion, narrowleaf falsepimpernel herb 12-24 weight portion, Chinese torreyanut 14-20 weight portion and common maidenhair spleenwort herb with root 15-20 weight portion.
The preparation method of described Chinese medicine additive comprises the following steps:
The first step, mixes in proportion by described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, adds hot reflux 1 ~ 3 hour, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 1 ~ 2 times to be again the ethanol of 85 ~ 95%, to add hot reflux 1 ~ 3 hour that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders, obtain Chinese medicine additive powder.
The invention has the beneficial effects as follows: feed of the present invention contains with clearing heat and detoxicating, cooling blood and hemostasis is the Chinese medicine additive of primary treatment principle, based on theory of traditional Chinese medical science, from entirety, control combines, effective dispeling disease and evil, reach good clinical therapeutic efficacy, Chinese medicine additive adopts natural Chinese traditional medicines material, and toxic and side effect is low, drug residue free; Chinese medicine additive and other raw materials cooperatively interact, not only can treat eel Hemorrhagic open-mouth disease, improve the disease-resistant evil ability of defence of body, the production performance of eel can also be improved, consumer plays good health-care effect after eating this type of eel, improves the economic benefit of culturist.
Detailed description of the invention
Chinese veterinarian's theory is thought when a variety of causes causes train of thought damage or abnormal circulation of blood, blood from overflowing arteries and veins will be caused outer and form blood trouble.Say as " Sanyin Ji Yi Bingzheng Fang Lun is lost blood and chatted opinion ": " husband's blood still water also, water by ground row, hundred rivers are all managed, then without stop up determine anxiety.The circumfluence of blood in person honor, warp, mansion, Yu, outward not by four gas are hindered, inside not by the seven human emotions are strongly fragrant, naturally pleasantly.Just in case micro-refreshing joint a surname, must cause heap soil or fertilizer over and around the roots and close, therefore blood must not follow through streamer, flourishly support hundred arteries and veins, or tears or loose, or lower and die anti-, or inverse and overflow, be tell, be defeated in battle, just, all card lifes of profit, sweat, phlegm here." Haemorrhagic Mouth-opening Disease of The Eel, anguilla Japonica mainly intimately smokedly burns, compel the absurd row of blood and failure of keeping fluid due to qi deficiency, blood overflows the outer two class reasons of arteries and veins.
Based on above-mentioned Chinese veterinarian's therapy theory, be primary treatment principle in line with clearing heat and detoxicating, cooling blood and hemostasis, the invention provides a kind of feed containing Chinese medicine additive, in feed, add Chinese medicine additive, thus the generation of control Haemorrhagic Mouth-opening Disease of The Eel, anguilla Japonica.Eel compound feed of the present invention comprises that expanded soybean, wheat, dried silkworm chrysalis, earthworm are dry, SDPP, bone meal, corn oil, Choline Chloride, vitamin premix, microelement pre-mix material, complex enzyme formulation and Chinese medicine additive; Wherein, Chinese medicine additive comprises following raw medicinal material: schizonepeta, dandelion, scouring rush, the root of large-flowered skullcap, cordate houttuynia, Herba Andrographitis, Lasiosphaera fenzlii, moutan bark, sweet wormwood, the root bark of Chinese wolf-berry, wolf's milk, tinosporae, field thistle, cape jasmine, cacumen biotae, hairyvein agrimony, radix boehmeriae, cogongrass rhizome, reed rhizome, madder, justicia, narrowleaf falsepimpernel herb, Chinese torreyanut and common maidenhair spleenwort herb with root.
The pharmacological property of above-mentioned each raw medicinal material is as follows:
Schizonepeta: taste is pungent, micro-hardship, property is micro-wet; Enter lung, Liver Channel." Japan hanako materia medica ": " sharp the five internal organs, promoting digestion to eliminate stagnation, sobers up.Heat-dissipating of cooking is eaten and is simmered tea, and controls a wind and sweating; Fermented soya beans, salted or other wise juice is decocted and is controlled sudden and violent typhoid fever." " detailed outline ": " throat, the sore that disappears swells for loose wind-heat, refresh oneself.Control Xiang Qiang, black flower in order, and raw sore, cloudy ruined, spit blood, bleeding from five sense organs or subcutaneous tissue, lower blood, bloody flux, metrorrhagia, anal fistula." main cold, fever, headache, eye itching, cough, abscess of throat, measles, carbuncle swells, sore scabies, postpartum anemic fainting.For flu, headache, measles, rubella, sore from the beginning of.Fry charcoal treating hematochezia, uterine bleeding, postpartum anemic fainting.Schizonepeta decoction has stronger antibacterial action to staphylococcus aureus and corynebacterium diphtheriae.Make fever in rabbits with typhoid fever mixed vaccine, give Schizonepeta tenuifolia decoction or ethanol preserved material 2g/kg gavage, find that there is faint refrigeration function.Catnip oil can reduce normal rat body temperature; Also have sedation, catnip oil (0.5ml/kg) is to rabbit gavage, and its movable minimizing as seen, limb muscle is slightly lax.Catnip oil can obviously extend acetylcholine and histamine mixed liquor causes the incubation period of breathing heavily to cavy, reduces the number of animals occurring to twitch; The GPTSM that also can cause anti-acetylcholine or histamine shrinks; Still there is phlegm-dispelling functions.
Dandelion: the effect with resisting pathogenic microbes, Dandelion Injectable Solution has stronger bactericidal action to staphylococcus aureus resistance bacterial strain, hemolytic streptococcus in vitro, also has certain bactericidal action to Diplococcus pneumopniae, meningococcus, corynebacterium diphtheriae, Pseudomonas aeruginosa, proteus, shigella dysenteriae, typhoid bacillus etc. and micrococcus catarrhalis.Dandelion extract (1:400) can suppress tulase in vitro.Dandelion water decoction (1:80) can delay ECHO11 viral cytopathic.Taraxol extract 31mg/kg can kill Leptospira.Water logging agent has inhibitory action to various skin fungi.Decoction, to Oral Administration in Rats, absorbs good, can keep certain antibacterial action in urine.Also have protect the liver, the effect of cholagogic, by dandelion decoction gavage or with Dandelion Injectable Solution injection, the glutamic-pyruvic transaminase caused carbon tetrachloride raises obvious inhibitory action; Significantly can alleviate the Histological change that carbon tetrachloride hepatic injury causes.Have report to point out, dandelion has choleretic effect in animals.Herba Taraxaci liquid gavage can make gallbladder contraction, and oddi's sphincter relaxes, and is conducive to bile and enters in intestines.Clinically to chronic gallbladder spasmolytic and calculosis effective.Also there is immunologic function, dandelion decoction can significantly improve PBLC blast transformation rate in vitro, Taraxacum Polysaccharides significantly can strengthen ehrlich carcinoma and MM46 tumor-cell antigen induced mice foot pad delayed allergy intensity, and have administration time more effective feature more backward, the administration on the 11st ~ 20th namely after antigenic stimulus or 2 ~ 20 the next day administration have obvious effect.Taraxacum Polysaccharides lumbar injection significantly can strengthen the CDCC of mouse antibodies dependence macrophage.
Scouring rush: taste is sweet, bitter, property is put down; Return lung, Liver Channel.Compendium of Material Medica: " scouring rush, with the Chinese ephedra similar shape same sex, therefore also can sweating expelling pathogenic factors from muscles and skin, rise loose fiery strongly fragrant rheumatism, control all blood diseases of eyes also." " book on Chinese herbal medicine justice ": " sweating, expelling pathogenic factors from muscles and skin.Cure the wound cold, malaria.Curing rheumatism, loose fire-evil." scouring rush's alcohol extract 10-15g/kg lumbar injection or 20g/kg duodenal administration, there is lasting hypotensive effect to anesthetized cat.Step-down intensity and hold time and have certain correlation with dosage.And can to the effect of antihistamine vasoconstriction, still have hypotensive effect to the cat of cutting off spinal cord, therefore think the periphery property at its step-down position.Obvious dilating effect is had to rabbit myocardium vessel.Have excitation to rabbit intestinal and GPI during scouring rush's alcohol extract low concentration, myenteron contraction frequency and Muscle tensility can be made to increase, and contractive amplitude strengthens, then in inhibitory action during high concentration.Scouring rush's parenteral solution breathes rabbit and heart in place has no significant effect; Certain inhibitory action is had to the convergent force of rabbit isolated heart.
The root of large-flowered skullcap: property is bitter, cold.Return lung, courage, spleen, large intestine, small intestinl channel." book on Chinese herbal medicine converges and says ": " clear flesh is brought down a fever, and radix bupleuri is best, so can not reach table by cool flesh without the root of large-flowered skullcap.The fire of the part of the body cavity above the diaphragm housing the heart and lungs, mountain mast can fall, and so the house root of large-flowered skullcap can not go up refresh oneself.So Fang Mai section with clear flesh bring down a fever, speciality of carbuncle and ulcers with detoxify and promote granulation, bright section with heat radiation improving eyesight, women section is with it antiabortive reason warp, and first of this Gai Zhu section is semi-exterior-interior, agent is also." can heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, antiabortive, hypotensive.For damp-warm syndrome, heat temperature evil of vomitting uncomfortable in chest, damp and hot ruffian is full, and rush down dysentery, jaundice, cough with lung heat, high hot polydipsia, blood-head tells nosebleed, carbuncle sore tumefacting virus, fetal irritability.The root of large-flowered skullcap has antipyretic, calm, hypotensive, diuresis, reduction capillary permeability, suppresses the effects such as intestinal motility, to staphylococcus, blood dissolubility streptococcus, Diplococcus pneumopniae, typhoid bacillus, dysentery coccus, ewcastle disease, Pseudomonas aeruginosa, there is certain inhibitory action, have good curative effect to the infection of the upper respiratory tract, chronic bronchitis, bacillary dysentery etc.
Cordate houttuynia: pungent, is slightly cold.Return lung channel, be used as medicine, the traditional Chinese medical science thinks that its taste is pungent, cold, energy is clearing heat and detoxicating, sore, promoting urination and removing dampness, stomach strengthening and digestion promoting are treated in the detumescence of row's pain, by the lung carbuncle, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach etc. of controlling real heat, heat poison, damp evil, disease heat are trouble, alone or compatibility compound, the equal determined curative effect of use of oral administration and externally or multiple Dietotherapy method among the people.Pharmacological research, cordate houttuynia master is containing volatile oil, and the multiple components such as decanoyl acetaldehyde decanoy acetaldehyde, have suppression antibacterial action to various Xenorhabdus, coccus, influenza virus, Leptospira etc., and can improve human immunity regulatory function.
Herba Andrographitis: have clearing heat and detoxicating, anti-inflammatory, swelling and pain relieving effect.Cure mainly bacillary dysentery, urinary tract infections, acute tonsillitis, enteritis, sphagitis, pneumonia and influenza etc., external application can treat sore furuncle poison, trauma infection contamination etc.Herba Andrographitis has eliminating inflammation and expelling toxin effect, once multi-infection disease was applied to clinically, comprise trauma infection contamination, furuncle, carbuncle, erysipelas, the infection of the upper respiratory tract, acute and chronic tonsillitis, acute and chronic pharyngitis, acute/chronic bronchitis, acute bacillary dysentery, acute gastroenteritis, urinary tract infections, endometritis, pelvic infecton, tympanitis, periodontitis etc., all have curative effect in various degree.Preparation and usage: make injection punishment, oral capsule or tablet, consumption must be looked various places and produce the different content of preparation and different.To general inflammation infection, can the decoction of Herba Andrographitis hay 2 ~ 3 money, every day 1 dose; Or tablet (the suitable crude drug in whole of every sheet 1 gram) takes orally, each 4 ~ 8, every day 3 ~ 4 times.To the cutization pyogenic infection surface of a wound, available Folium Andrographis is ground into powder, makes the 1:4 aqueous solution, leaching gauze external application wound.Auristilla topical application be can be made into otitis media suppurative, simultaneously Tabellae Andrographitis for oral administration.
Lasiosphaera fenzlii: pungent, flat, nontoxic.Main be used as local hemostatic, doublely control sore-throat, aphonia etc.Traumatism and bleeding, nosebleed epistaxis, postextraction hemorrhage: Lasiosphaera fenzlii tears epithelium off, gets inner sponge suede sample thing compressing bleeding part or fills in nostril, filling gum place, have good hemostatic function.Ulcer sore furuncle: Lasiosphaera fenzlii conidia powder, is in harmonious proportion with honey and applies affected part.Pernio: first embathed by affected part warm water, makes local rubescent, wipe dry after to apply ointment or plaster Lasiosphaera fenzlii by affected part size.Lasiosphaera fenzlii Reics has to oral cavity hemorrhagic illness usefulness of significantly stopping blooding, not second to starch sponge or gelfoam, also effective to nosebleed.Lasiosphaera fenzlii Reics decoction has certain inhibitory action to staphylococcus aureus, Pseudomonas aeruginosa, proteus and Diplococcus pneumopniae, also has inhibitory action to minority pathomycete.
Moutan bark: bitter, pungent, cold nature, enters the heart, liver, kidney channel." herbal classic ": " main fever and chills, apoplexy Chi Zong, convulsion, frightened epilepsy perverse trend, except the hard hemostasis of disease stays house stomach, five viscera settling, treat carbuncle sore." " Japan hanako materia medica ": " except perverse trend, happy look, clearance natural fibre line of meat blood vessels, apocenosis, logical menstruation, disappears and flutters damage hemostasis, continuous muscles and bones, and except wandering arthritis, fall tire lower eyelid, postpartum all cold and hot vim and vigour."。Compendium of Material Medica: " nourishing Yin and falling fire, separate spot poison, throat, diuresis stasis.Descendant specially controls fire mutually with yellow tiller, does not know that the merit of the root bark of tree peony more wins also.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it." there is the effect of clearing heat and cooling blood, promoting blood circulation to remove blood stasis, be mainly used in treatment warm heat disease heat invading xuefen, send out spot, tell nosebleed, pyreticosis later stage hot Fu Yin divides heating, deficiency of Yin osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhoea, carbuncle sore tumefacting virus, falls and flutter the card such as the pain of injury, beriberoid pyretic arthralgia.Be apt to purify the blood, and invigorate blood circulation, thus have effect of cool the blood dissipate blood stasis, make blood flow freely and not stay the stasis of blood, the absurd clearly and not row of blood-head.Therefore to diseases such as intense heat in the blood, liver kidney hyperactivity of fire and stagnation of blood stasis, all rely on as key medicine.Moutan bark can increase CF to the anesthetized dog heart, reduces cardiac output, reduces the effect of left room work done.The mouse heating that Paeonol oral disposition typhoid fever, paratyphoid vaccine cause has refrigeration function, and reduces normal mouse body temperature.
Sweet wormwood: bitter, pungent, cold.Return liver, gallbladder channel, three burnt, kidney channels.Function: clear abnormal heat thoroughly, cool blood, except steaming, removes and steams, preventing malaria.For summer-heat evil heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to yin labor heat, malaria fever and chills, jaundice with damp-heat pathogen.This product bitter-cold herbs expelling heat, pungent perfume (or spice) falls apart thoroughly, and the kind the moon that makes divides a latent heat thoroughly to reach outer faling apart, and is fever due to yin deficiency key medicine, has relieving summer-heat in addition, cut cruel merit.Arteether extracts neutral fraction and its rare alcohol medicinal extract to mouse malaria, monkey malaria and people's malaria all in remarkable Antimalarial.Decocting liquid has stronger bacteriostasis to MRSE, micrococcus catarrhalis, bacillus anthracis, corynebacterium diphtheriae, also has certain inhibitory action to staphylococcus aureus, Pseudomonas aeruginosa, shigella dysenteriae, tuberculosis stalk bacterium etc.Ether extract, rare alcohol medicinal extract and qinghaosu to mouse malaria, monkey malaria, people's malaria all in remarkable Antimalarial.Qinghaosu also can reducing heart rate, suppresses myocardial contractive power, reduces coronary flow.
The root bark of Chinese wolf-berry: cold in nature, taste is sweet; Enter lung, liver, kidney channel." not Lu ": " main air wets, lower breast side of body gas, the headache of visitor's heat, mends internal injury great Lao and to hiss suction, hard muscle, reinforcing yin essence, sharp intestine and small intestine, resistance to cold and heat." " book on Chinese herbal medicine is stated ": " cures mainly deficient fever, alternative fever and chill, allly sees blood trouble, nosebleed epistaxis, cough blood, and cough, breathe heavily, disappear illness, apoplexy, and dizzy, convulsion is chronic, pain in the back, migratory arthralgia, beriberi, oedema, and dysphoria is throbbed with fear, forgetful, urinary obstruction, reddish and whitish turbid urine." except steaming, fire falls to cool blood in clearing lung-heat.Cure mainly hectic fever due to yin deficiency, hectic fever due to yin night sweat, infantile malnutrition generates heat, and quench one's thirst, lung is coughed and breathed heavily, and spits blood, bleeding from five sense organs or subcutaneous tissue, hematuria.Modern times are used for the treatment of high blood pressure, flat wart, palmoplantar verruca, universal eczema, pulpitis pain etc.
Wolf's milk: be the wolf's milk of euphorbia plant, is a kind of Chinese medicine, gathers at summer, Qiu Erji, and removing impurity, dries." book on Chinese herbal medicine converges and says ": " cooling blood to dissipate stasis, removing toxic substances stops the medicine of dysentery also.Kind through-flow blood vessels, specially clear up carbuncle.All blood is sick and because of hot institute envoy, suitable with it.If non-blood-head is disease, and the thin weak person of stomach Qi, again when consideration row." Compendium of Material Medica: " main carbuncle is swollen dislikes sore, and it is hemorrhage that Jin Ren flutters damage, bloody flux, lower blood, metrorrhagia, and the blood that can fall apart stops blooding, diuresis." can be clearing heat and detoxicating, dampness removing removing jaundice, promoting blood circulation and hemostasis.Main dysentery, have loose bowels, jaundice; Hemoptysis; Spit blood; Hematuria; Have blood in stool; Uterine bleeding; Agalactia; Treating swelling and pain by traumatic injury and pathopyretic ulcer etc.Blood-head spit blood, bleeding from five sense organs or subcutaneous tissue person, can with radix rehmanniae recen, the same use of moutan bark, to increase the merit of cooling blood and hemostasis.Jaundice with damp-heat pathogen, difficult urination person, can be alone, or with the compatibility such as oriental wormwood, cape jasmine, with heat-clearing and dampness-resolving, also can be used for ulcer dislike sore, injuries from falls as well eczema ulcer, burn and scald and all cards of venomous snake bite, clinical multiplex fresh goods mashes external application.
Tinosporae: bitter, cold.Return lung, large intestine channel.Function cures mainly: clearing heat and detoxicating, relieve sore throat, pain relieving.For abscess of throat, ulcer serious case of furuncle, has loose bowels, dysentery, gastral cavity abdomen heat pain.
Field thistle: sweet, bitter, cold.The thoughts of returning home, Liver Channel." classifying herbal ": " control blood and drench distending pain, traumatic injury, redly to collapse, leukorrhea." function cooling blood and hemostasis, eliminating stasis to resolve swelling.For bleeding from five sense organs or subcutaneous tissue, spit blood, hematuria, has blood in stool, metrostaxis, traumatism and bleeding, carbuncle sore tumefacting virus.Obviously can raise the blood pressure of non-reserpinization rat after field thistle crystallization iv, boosting intensity exists obviously, and obviously weakens the boosting of reserpinization rat field thistle crystallization, and without dose-effect relationship, the similar cruel amine of this interaction property.Field thistle water decoction 0.075g/ml nutrient solution is to the rabbit aorta strip performance contraction of tool adrenergic a acceptor, and this effect can by a ARBs phentolamine institute antagonism.Field thistle is traditional Hemostatic of traditional herb medicine, has confirmed that it has anastalsis, and obtains active ingredient of stopping blooding.Field thistle hemostasis mainly through making local vasoconstriction, suppresses fibrinolytic and plays effect.
Cape jasmine: bitter, cold.The thoughts of returning home, lung, tri-jiao channel.Function cures mainly: fruit: purging intense heat relieving restlessness, reducing fever and causing diuresis, removing pattogenic heat from the blood and toxic material from the body.Vexed for pyreticosis, jaundice urine is red, blood strangury and dry pain, and blood-head tells nosebleed, red eye, swell pain, pathogenic fire,toxin and furuncles; Control bruise pain outward.
Cacumen biotae: " Amplification on Materia Medica addendum ": " how dry its property is for CedarLeaves, the key medicine of tonifying yin, of a specified duration it, large beneficial spleen soil, to grow its lung." " Bencao Jingshu ": " and cacumen biotae, bitter and tepor, justice should and in being slightly cold, therefore in vain red in all metrorrhagias of winner.With regard to beneficial gas of making light of one's life by commiting suicide, make us resistance to cold and heat, be then slightly same as the property of cypress reality.Only myogenic is dried numbness, be its length of solely arrogating to oneself also." " Mingyi Bielu ": " main haematemesis, bleeding from five sense organs or subcutaneous tissue, dysentery blood, metrorrhagia are in vain red.To make light of one's life by commiting suicide beneficial gas, make us resistance to cold and heat, numbness of drying, myogenic." cacumen biotae decoction can obviously shorten bleeding time and clotting time, its hemostasis active ingredient is Quercetin and tannin.In addition, effects such as still having antibechic, eliminate the phlegm, relieving asthma, be calm.Experiment in vitro shows, these product all have inhibitory action to staphylococcus aureus, micrococcus catarrhalis, shigella dysenteriae, typhoid bacillus, corynebacterium diphtheriae etc.
Hairyvein agrimony: bitter, puckery, property is put down, the thoughts of returning home, Liver Channel, " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control married woman's menstruation or before or after, leukorrhea with reddish discharge, the cold stomachache in face, with the passing of time red white bloody flux." " hundred careless mirrors ": " lower gas is invigorated blood circulation, reason all kinds of diseases and ailments, and loose ruffian is full; Fall to beat and spit blood, metrorrhagia, dysentery, discharging fresh blood stool." astringing to arrest bleeding, only dysentery, desinsection.Be widely used in various hemorrhage card, such as: haematemesis, hematuria, have blood in stool, uterine bleeding, spitting of blood, bleeding from five sense organs or subcutaneous tissue, dysentery, internal lesion caused by overexertion takes off power, carbuncle swell, fall beat, the cards such as traumatic bleeding.Allergic reaction: show as uncomfortable in chest, breathe hard, palpitaition, agitation, dizzy, sweat all over, pale complexion, cold limbs, shiver with cold, blood pressure decline.Severe one still has dizziness, flushed face, sweats all over.Poisoning retrobulbar neuritis is blind, abdominal pain diarrhea, vomiting, flushing, blood pressure decline.
Radix boehmeriae: taste is sweet is sliding, cold, nontoxic; Enter lung, the spleen channel." Japan hanako materia medica ": " control heart diaphragm heat, blood under leakage tire, antenatal rear vexed vexed, the capable hot disease in sky, large thirsty large Kuang , An poisoned arrow, snakeworm are stung." essentials of Matea Medica: " and tonifying yin, the broken stasis of blood, antipyretic, moisturize.Control ulcer, carbuncle on the back, metal-inflicted wound, injured, chicken, fish-bone are choked." function heat-clearing, hemostasis, removing toxic substances, the loose stasis of blood.Control pyreticosis large yearningly, mad greatly, blood drenches, the retention of urine, spits blood, lower blood, leukorrhea with reddish discharge, erysipelas, and carbuncle swells, traumatic injury, snake bite and insect sting.The extract of siam falsenettle herb soaks the artificial ramie sheet surface of a wound of rat and mouse tail end, can use oligemia, and the bleeding time shortens. to Mouse oral or lumbar injection, also there is effect same.Acylate contained by radix boehmeriae and alkaloid all have inhibitory action to gram positive bacteria and negative bacterium in vitro.
Cogongrass rhizome: taste is sweet, cold in nature, enter lung, stomach, urinary bladder channel." Bencao Tujing ": " lalang grass rhizome, the present has it everywhere.Spring sprouts, and cloth ground is as pin, and the thatch pin called between custom, also can eat, very beneficial children's.Xia Sheng spends in vain, so fine, withered to the autumn, and its root, to pure white, also very sweet and refreshing, adopted root June and used." Compendium of Material Medica: " antiemetic is defeated in battle all blood, and typhoid fever hiccup, lung heat breathes heavily urgency, oedema, jaundice, relieving alcoholism." have the effect of cooling blood and hemostasis, reducing fever and causing diuresis, be mainly used in haematemesis, hemoptysis that lung stomach has accumulated heat, damp invasion of lower energizer pents up the hematuria of bladder, and pyreticosis polydipsia draws drink, gastropyretic vomiting, the cards such as jaundice with damp-heat pathogen.Cogongrass rhizome decoction and water logging agent gavage, and have diuresis to normal rabbits, administration 5-10 days, and diuresis is the most obvious.Cogongrass rhizome decoction has obvious inhibitory action to Fu Shi and sonne bacillus in vitro, but to will Hayes and the effect of easypro Shigella flexneri nothing.Coixol contained by cogongrass rhizome has inhibitory action to the contraction of skeletal muscle and metabolism.
Reed rhizome: sweet, cold; Return lung channel, stomach warp." property of medicine opinion ": " large heat can be separated, appetizing.Control the sound of vomiting of choking more than." " Japan hanako materia medica ": " when controlling fever and chills, disease is unhappy, good pregnant popular feeling heat, and it is thirsty to rush down dysentery people." clearing heat and promoting fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Cure mainly: drench puckery pain for pyreticosis polydipsia, gastropyretic vomiting, cough with lung heat, lung carbuncle pyemesis, heat.Reed rhizome is used for gastropyretic vomiting.Reed rhizome can clearing heat to ease the stomach preventing or arresting vomiting, does not grow again greasyly to hinder stomach, therefore to vomit the key medicine of the sound of vomiting for controlling stomach energy.The lighter is alone, and severe one often joins caulis bambusae in taenian, ginger, polished rice etc., falls inverse to strengthen heat-clearing, and the merit of middle preventing or arresting vomiting, and side is as Thousand Golden Prescriptions Rhizomatis Phragmitis Potion.The contractile response caused by electro photoluminescence of frog neuromuscular sample and the oxygen of diaphragm in rats can be suppressed to absorb and anaerobic glycolysis, have relexation to isolated guinea pig intestinal tube.
Madder: cold in nature, bitter, returns Liver Channel, " Bencao Jingshu ": " rubia, the key medicine of the cool blood of promoting circulation of blood.Main numbness and subcutaneous ulcer.Subcutaneous ulcer has five, this its for controlling, lid does not refer to jaundice of blood stasis, and not specially in damp and hot person yet.Numbness person's blood is sick, the soft heavily fortified point of promoting circulation of blood.Then numbness self-healing." " Japan hanako materia medica ": " and only profuse nasal bleeding, under band, postpartum anemic fainting, breast knot, menstruation is more than, intestines wind hemorrhoid complicated by anal fistula, apocenosis; Control sore furuncle, let out essence, hematuria, flutter damage hemostasis." effect: cooling blood and hemostasis; Promoting blood circulation and removing blood stasis, cure mainly blood-head spitting of blood, haematemesis, bleeding from five sense organs or subcutaneous tissue, hematuria, have blood in stool, uterine bleeding, through closing, postpartum stasis blocking stomachache, the card such as traumatic injury, arthralgia due to wind-dampness, jaundice, sore carbuncle, hemorrhoid are swollen.The antitussive action of madder is comparatively strong, eliminates the phlegm, relievings asthma and take second place, and have certain antiinflammation; After taking medicine, dry, the moist rale of lung and wheezing sound majority reduce or disappear.
Justicia: micro-hardship, cold.Function cures mainly: clearing heat and detoxicating, inducing diuresis to reduce edema, preventing malaria.For cold, fever, malaria, abscess of throat, infantile malnutrition, dysentery, enteritis, nephritic dropsy, urinary infection, chyluria; Carbuncle sore furuncle is controlled in external application, traumatic injury.
Narrowleaf falsepimpernel herb: property is put down, taste is worked hard.Function cures mainly: disappear hot dampness removing, and stomach, goes the stasis of blood.To harness the Yellow River subcutaneous ulcer, dysentery, acute gastroenteritis, acute laryngitis, tonsillitis, traumatic injury.
Chinese torreyanut: sweet is flat.Return lung, stomach, large intestine channel.Function cures mainly: killing insect and eliminating accumulation, moistening dryness for relaxing bowels.For hookworm, roundworm, taeniasis, abdominal pain due to enterositosis, infantile malnutrition, constipation.
Common maidenhair spleenwort herb with root: light is cool.Function cures mainly: clearing heat and detoxicating, regulating menstruation, hemostasis, and convergence is band only.For infantile hyperpyrexia, leukorrhea, irregular menstruation; Burn and scald is controlled in external application, traumatism and bleeding, furuncle swelling toxin, venomous snake bite.
Wherein, in feed, propolis seals the natural gum gathered from plant petal and trunk, be mixed into a kind of colloidal solid material with aromatic odor that its material such as mandibular gland secretion and beeswax is formed, it is rich in abundant trace element, enzyme, sesame oil essence and a large amount of flavone compound, strengthens digesting and assimilating and anabolism in vivo of nutriment, promote intestinal movement, regulating intestinal canal growth of microorganism, promotes cellular immunity and humoral immune function, builds up health and anti-stress ability; Nano montmorillonite directly to adsorb on the one hand mycotoxin wherein, germ, virus, toxic metabolic products and virulence factor after entering young common eel intestines and stomach; can also be combined with intestinal mucosa mucus glycoprotein on the other hand and form diaphragm, preferentially can be adsorbed by nano montmorillonite when virulence factor attacks intestinal mucosa and protect intestinal mucosa benefit to award damage.
Wherein, in described feed, the parts by weight of each raw material are: expanded soybean 15-21 weight portion, wheat 16-25 weight portion, dried silkworm chrysalis 21-29 weight portion, earthworm do 24-29 weight portion, SDPP 3-7 weight portion, bone meal 5-8 weight portion, nano montmorillonite 2-6 weight portion, propolis 5-10 weight portion, corn oil 1-4 weight portion, Choline Chloride 0.3-1.5 weight portion, vitamin premix 0.05-0.1 weight portion, microelement pre-mix material 0.05-0.12 weight portion, complex enzyme formulation 1-3 weight portion and Chinese medicine additive 2-5 weight portion.
In described feed, the parts by weight of each raw material are preferably: expanded soybean 17 weight portion, wheat 21 weight portion, dried silkworm chrysalis 26 weight portion, earthworm dry 27 weight portions, SDPP 5 weight portion, bone meal 6 weight portion, nano montmorillonite 4 weight portion, propolis 7 weight portion, corn oil 2 weight portion, Choline Chloride 0.5 weight portion, vitamin premix 0.08 weight portion, microelement pre-mix material 0.08 weight portion, complex enzyme formulation 2 weight portion and Chinese medicine additive 3 weight portion.
Described Chinese medicine additive comprises following raw medicinal material: schizonepeta, dandelion, scouring rush, the root of large-flowered skullcap, cordate houttuynia, Herba Andrographitis, Lasiosphaera fenzlii, moutan bark, sweet wormwood, the root bark of Chinese wolf-berry, wolf's milk, tinosporae, field thistle, cape jasmine, cacumen biotae, hairyvein agrimony, radix boehmeriae, cogongrass rhizome, reed rhizome, madder, justicia, narrowleaf falsepimpernel herb, Chinese torreyanut and common maidenhair spleenwort herb with root.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are: schizonepeta 10-20 weight portion, dandelion 15-25 weight portion, scouring rush 10-20 weight portion, root of large-flowered skullcap 12-17 weight portion, cordate houttuynia 17-25 weight portion, Herba Andrographitis 10-17 weight portion, Lasiosphaera fenzlii 10-14 weight portion, moutan bark 14-20 weight portion, sweet wormwood 10-15 weight portion, root bark of Chinese wolf-berry 14-20 weight portion, wolf's milk 10-16 weight portion, tinosporae 13-19 weight portion, field thistle 12-17 weight portion, cape jasmine 10-15 weight portion, cacumen biotae 15-20 weight portion, hairyvein agrimony 10-15 weight portion, radix boehmeriae 15-22 weight portion, cogongrass rhizome 13-17 weight portion, reed rhizome 15-20 weight portion, madder 10-16 weight portion, justicia 13-20 weight portion, narrowleaf falsepimpernel herb 12-24 weight portion, Chinese torreyanut 14-20 weight portion and common maidenhair spleenwort herb with root 15-20 weight portion.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are preferably: schizonepeta 15 weight portion, dandelion 19 weight portion, scouring rush 15 weight portion, the root of large-flowered skullcap 15 weight portion, cordate houttuynia 20 weight portion, Herba Andrographitis 14 weight portion, Lasiosphaera fenzlii 12 weight portion, moutan bark 17 weight portion, sweet wormwood 12 weight portion, the root bark of Chinese wolf-berry 17 weight portion, wolf's milk 13 weight portion, tinosporae 17 weight portion, field thistle 14 weight portion, cape jasmine 12 weight portion, cacumen biotae 18 weight portion, hairyvein agrimony 12 weight portion, radix boehmeriae 18 weight portion, cogongrass rhizome 15 weight portion, reed rhizome 17 weight portion, madder 13 weight portion, justicia 17 weight portion, narrowleaf falsepimpernel herb 17 weight portion, Chinese torreyanut 18 weight portion and common maidenhair spleenwort herb with root 18 weight portion.
Wherein, the preparation method of Chinese medicine additive comprises the following steps:
The first step, mixes in proportion by described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, adds hot reflux 1 ~ 3 hour, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 1 ~ 2 times to be again the ethanol of 85 ~ 95%, to add hot reflux 1 ~ 3 hour that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders, obtain Chinese medicine additive powder.
Wherein, described complex enzyme formulation comprises one or more in amylase, protease, cellulase, 1,4 beta-glucanase, pectase and phytase.
The preparation method of feed comprises the following steps:
Pulverising step: take that expanded soybean, wheat, dried silkworm chrysalis, earthworm are dry, bone meal, nano montmorillonite and propolis by weight percentage, drops into pulverizer and pulverizes;
Blend step: by weight percentage by after SDPP, corn oil, Choline Chloride, vitamin premix, microelement pre-mix material and Chinese medicine additive premixed, more fully mix with the comminuting matter obtained in pulverising step;
Ultramicro grinding step: drop into pulverizer and carry out ultramicro grinding;
Granulation step: drop into granulator, granulates, makes its gelatinization degree reach 90% at 70-80 DEG C;
Spraying process: the surface by weight complex enzyme formulation being sprayed to pellet.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine additive
Embodiments provide a kind of feed Chinese medicine additive being used for the treatment of eel Hemorrhagic open-mouth disease, the parts by weight of its each raw medicinal material are: schizonepeta 15 weight portion, dandelion 19 weight portion, scouring rush 15 weight portion, the root of large-flowered skullcap 15 weight portion, cordate houttuynia 20 weight portion, Herba Andrographitis 14 weight portion, Lasiosphaera fenzlii 12 weight portion, moutan bark 17 weight portion, sweet wormwood 12 weight portion, the root bark of Chinese wolf-berry 17 weight portion, wolf's milk 13 weight portion, tinosporae 17 weight portion, field thistle 14 weight portion, cape jasmine 12 weight portion, cacumen biotae 18 weight portion, hairyvein agrimony 12 weight portion, radix boehmeriae 18 weight portion, cogongrass rhizome 15 weight portion, reed rhizome 17 weight portion, madder 13 weight portion, justicia 17 weight portion, narrowleaf falsepimpernel herb 17 weight portion, Chinese torreyanut 18 weight portion and common maidenhair spleenwort herb with root 18 weight portion.
Its preparation method comprises the following steps:
The first step, mixes in proportion by described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 90%, adds hot reflux 2 hours, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 1.5 times to be again the ethanol of 90%, to add hot reflux 2 hours that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 1.5 hours, pulverize, sieve, obtain 350 object micropowders, obtain Chinese medicine additive powder.
Embodiment 2 feed
Embodiments provide a kind of eel compound feed that can be used in preventing and treating eel Hemorrhagic open-mouth disease, in feed, the parts by weight of each raw material are: expanded soybean 17 weight portion, wheat 21 weight portion, dried silkworm chrysalis 26 weight portion, earthworm dry 27 weight portions, SDPP 5 weight portion, bone meal 6 weight portion, nano montmorillonite 4 weight portion, propolis 7 weight portion, corn oil 2 weight portion, Choline Chloride 0.5 weight portion, vitamin premix 0.08 weight portion, microelement pre-mix material 0.08 weight portion, complex enzyme formulation 2 weight portion and Chinese medicine additive 3 weight portion.
Wherein, Chinese medicine additive is the Chinese medicine additive powder in embodiment 1; Complex enzyme formulation comprises amylase, protease, cellulase, 1,4 beta-glucanase and pectase.
In order to better realize foregoing invention object, the invention provides a kind of preparation method of eel compound feed, described preparation method comprises the following steps:
Pulverising step: take that expanded soybean, wheat, dried silkworm chrysalis, earthworm are dry, bone meal, nano montmorillonite and propolis by weight percentage, drops into pulverizer and pulverizes;
Blend step: by weight percentage by after SDPP, corn oil, Choline Chloride, vitamin premix, microelement pre-mix material and Chinese medicine additive premixed, more fully mix with the comminuting matter obtained in pulverising step;
Ultramicro grinding step: drop into pulverizer and carry out ultramicro grinding;
Granulation step: drop into granulator, granulates, makes its gelatinization degree reach 90% at 70-80 DEG C;
Spraying process: the surface by weight complex enzyme formulation being sprayed to pellet.
Chinese herbal medicine is the product of the distinctive traditional Chinese medical theory of China and practice, its aboundresources, with a long history.Chinese herbal medicine immunity substance mass-energy improve human body immune function, resisting stress, disease-resistant, improve breeding performonce fo animals, and there is the advantages such as noresidue, not easily generation drug resistance, simultaneously also containing multiple nutritional components and bioactivator, have the double action of medicine and nutrition concurrently.For many years, generally believe that Chinese medicine has the advantage of low toxicity, in order to verify security and the antibiotic property of Chinese medicine additive of the present invention further, spy carries out following experiment.
Toxicity test
1, material prepares
1.1 animals: Kun Ming mice, are provided by Shandong University's Experimental Animal Center, SPF level, male and female dual-purpose, body weight 18-22g.By sex sub-cage rearing, dailyly to feed, freely drink water, room temperature 20-25 DEG C, relative humidity 45%-54%.
1.2 medicines: the Chinese medicine additive powder of the embodiment of the present invention 1, use distilled water wiring solution-forming during use.
1.3 bacterial classifications: salmonella, dust Xi Shi Escherichia coli, staphylococcus aureus are reference culture.
2, method
2.1 preliminary experiments: mouse 18, male and female half and half, are divided into 3 groups at random, and often organize 6, after fasting 12h, gavage gives 31.25%, 62.5%, 125% Chinese medicine additive 0.4ml/10g respectively, 3 times/d, interval 6h, and result is without dead mouse, and prompting cannot measure LD 50, therefore measure mouse maximum dosage-feeding on the 1st.
2.2 formal tests: separately get mouse 40, male and female half and half, be divided into control group and experimental group at random by body weight, sex, after fasting 12h, experimental group gavage 125%(Cmax) Chinese medicine additive 0.4ml/10g, 3 times/d, interval 6h.Control group gives normal saline with method.Observe and record the situations such as mouse diet, outward appearance, behavior, changes of weight, death.
3 results: one-way analysis of variance is carried out to the change of duration of test Mouse Weight with SPSS13.0 statistical software.Toxicity test result shows: experimental group and control group mice body weight increase overall all without significant difference.Period mouse hair gloss, activity freely, feed and excretion normal, find no other toxic reactions.In 14d, Mouse Weight is increased to (30.6 ± 1.1) g by (20.0 ± 1.1) g before testing, and does not occur death.During off-test, cervical dislocation puts to death mouse, dissects and visually observes main organs color and morphological change, the main organs no abnormality seens such as the result heart, liver, spleen, lung, kidney.Accordingly, Chinese medicine additive, through mouse stomach administration maximum pharmaceutical quantities 150g/kg on the 1st, has no overt toxicity reaction.
Contrast test
In July, 2011, certain eel culture field finds that the phenomenon that cranial cavity is hemorrhage appears in part eel, and oral cavity is often opened, and can not close.Choose the comparatively serious ill eel of the state of an illness 5, carry out dissection analysis of cases, find liver,spleen,kidney enlargement, and extreme anaemia, ultra-thin section observation is carried out to blood, can virion be seen in haemocyte.Be diagnosed as Hemorrhagic open-mouth disease.
Random choose 500 ill eels are as experimental subjects, and the situation that the hemorrhage and oral cavity of cranial cavity in various degree can not close all has appearred in 500 eels.Be divided into two groups at random, be respectively embodiment group and control group, often organize 250, be put in different fishponds respectively and feed.Embodiment group uses the forage feed of the embodiment of the present invention 2, does not carry out other process; Control group uses traditional eel feed to feed, and full pond float bactericide (sulphadiazine).Test is 40 days, and period record fish change of illness state only and death toll, result is as shown in table 1.Wherein, in process of the test, eel transference cure, body condition recovers normal completely, is recorded as recovery from illness; Eel symptom takes a turn for the better to some extent, the transference cure that the hemorrhage and oral cavity of cranial cavity can not close, and body condition recovers normal substantially; Invalid: exacerbation of symptoms or death.
Table 1 two experimental group fishes change of illness state table of comparisons bar
Group Sum Recovery from illness Effectively Invalid Efficient
Embodiment group 250 46 79 132 50.0%
Control group 250 8 23 219 12.4%
According to the data of table 1, use feed of the present invention to contain Chinese medicine additive, can be used in treatment eel Hemorrhagic open-mouth disease, with traditional therapy first than, the advantage such as there is good, the efficient height of result for the treatment of, have no side effect.
In a word, the present invention contains with clearing heat and detoxicating, cooling blood and hemostasis is the feed of the Chinese medicine additive of primary treatment principle, not only can treat eel Hemorrhagic open-mouth disease, improve the disease-resistant evil ability of defence of body, can also improve the production performance of eel, consumer plays good health-care effect after eating this type of eel, improves the economic benefit of culturist.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (6)

1. an eel compound feed, it is characterized in that, in described feed, the parts by weight of each raw material are: expanded soybean 15-21 weight portion, wheat 16-25 weight portion, dried silkworm chrysalis 21-29 weight portion, earthworm does 24-29 weight portion, SDPP 3-7 weight portion, bone meal 5-8 weight portion, nano montmorillonite 2-6 weight portion, propolis 5-10 weight portion, corn oil 1-4 weight portion, Choline Chloride 0.3-1.5 weight portion, vitamin premix 0.05-0.1 weight portion, microelement pre-mix material 0.05-0.12 weight portion, complex enzyme formulation 1-3 weight portion and Chinese medicine additive 2-5 weight portion,
In described Chinese medicine additive, the parts by weight of each raw medicinal material are: schizonepeta 10-20 weight portion, dandelion 15-25 weight portion, scouring rush 10-20 weight portion, root of large-flowered skullcap 12-17 weight portion, cordate houttuynia 17-25 weight portion, Herba Andrographitis 10-17 weight portion, Lasiosphaera fenzlii 10-14 weight portion, moutan bark 14-20 weight portion, sweet wormwood 10-15 weight portion, root bark of Chinese wolf-berry 14-20 weight portion, wolf's milk 10-16 weight portion, tinosporae 13-19 weight portion, field thistle 12-17 weight portion, cape jasmine 10-15 weight portion, cacumen biotae 15-20 weight portion, hairyvein agrimony 10-15 weight portion, radix boehmeriae 15-22 weight portion, cogongrass rhizome 13-17 weight portion, reed rhizome 15-20 weight portion, madder 10-16 weight portion, justicia 13-20 weight portion, narrowleaf falsepimpernel herb 12-24 weight portion, Chinese torreyanut 14-20 weight portion and common maidenhair spleenwort herb with root 15-20 weight portion.
2. eel compound feed according to claim 1, it is characterized in that, in described feed, the parts by weight of each raw material are: expanded soybean 17 weight portion, wheat 21 weight portion, dried silkworm chrysalis 26 weight portion, earthworm dry 27 weight portions, SDPP 5 weight portion, bone meal 6 weight portion, nano montmorillonite 4 weight portion, propolis 7 weight portion, corn oil 2 weight portion, Choline Chloride 0.5 weight portion, vitamin premix 0.08 weight portion, microelement pre-mix material 0.08 weight portion, complex enzyme formulation 2 weight portion and Chinese medicine additive 3 weight portion.
3. eel compound feed according to claim 1, it is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: schizonepeta 15 weight portion, dandelion 19 weight portion, scouring rush 15 weight portion, the root of large-flowered skullcap 15 weight portion, cordate houttuynia 20 weight portion, Herba Andrographitis 14 weight portion, Lasiosphaera fenzlii 12 weight portion, moutan bark 17 weight portion, sweet wormwood 12 weight portion, the root bark of Chinese wolf-berry 17 weight portion, wolf's milk 13 weight portion, tinosporae 17 weight portion, field thistle 14 weight portion, cape jasmine 12 weight portion, cacumen biotae 18 weight portion, hairyvein agrimony 12 weight portion, radix boehmeriae 18 weight portion, cogongrass rhizome 15 weight portion, reed rhizome 17 weight portion, madder 13 weight portion, justicia 17 weight portion, narrowleaf falsepimpernel herb 17 weight portion, Chinese torreyanut 18 weight portion and common maidenhair spleenwort herb with root 18 weight portion.
4. the eel compound feed according to any one of claim 1-3, is characterized in that, the preparation method of described Chinese medicine additive comprises the following steps:
The first step, mixes in proportion by described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, adds hot reflux 1 ~ 3 hour, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 1 ~ 2 times to be again the ethanol of 85 ~ 95%, to add hot reflux 1 ~ 3 hour that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders, obtain Chinese medicine additive.
5. the eel compound feed according to any one of claim 1-3, is characterized in that, it is multiple that described complex enzyme formulation comprises in amylase, protease, cellulase, 1,4 beta-glucanase, pectase and phytase.
6. the preparation method of the eel compound feed according to any one of claim 1-5, is characterized in that, described preparation method comprises the following steps:
Pulverising step: take that expanded soybean, wheat, dried silkworm chrysalis, earthworm are dry, bone meal, nano montmorillonite and propolis by weight, drops into pulverizer and pulverizes;
Blend step: by weight by after SDPP, corn oil, Choline Chloride, vitamin premix, microelement pre-mix material and Chinese medicine additive premixed, more fully mix with the comminuting matter obtained in pulverising step;
Ultramicro grinding step: drop into pulverizer and carry out ultramicro grinding;
Granulation step: drop into granulator, granulates, makes its gelatinization degree reach 90% at 70-80 DEG C;
Spraying process: the surface by weight complex enzyme formulation being sprayed to pellet.
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CN106666224A (en) * 2016-12-05 2017-05-17 浙江海洋大学 Marine fish health-care feed and application thereof
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