CN103599392B - For preventing and treating the feedstuff of hemorrhagic disease of grass carp - Google Patents
For preventing and treating the feedstuff of hemorrhagic disease of grass carp Download PDFInfo
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Abstract
The invention provides a kind of Chinese medicine composition for preventing and treating hemorrhagic disease of grass carp, its crude drug comprises the Radix Astragali, Herba Epimedii, Fructus Lycii, Radix Sophorae Flavescentis, Herba Andrographis, Cacumen Platycladi, Rhizoma Coptidis, Radix Et Caulis Acanthopanacis Senticosi, Galla Chinensis, Herba Plantaginis, Spora Lygodii, Rhizoma Chuanxiong, Fructus Crataegi, Herba Menthae, Herba Artemisiae Scopariae, the Radix Pulsatillae, Herba Portulacae, Herba Dendrobii, Resina Ferulae, the Rhizoma Atractylodis Macrocephalae, Conyza japonica, Herba Alternantherae sessilis and Radix Glycyrrhizae.Chinese medicine composition provided by the invention has efficiently, toxic and side effects is little, safety is high, remain the plurality of advantages such as few, and source is wide, cost is low.
Description
Technical field
The present invention relates to technical field of Chinese medicine, particularly relating to a kind of Chinese medicine composition for preventing and treating hemorrhagic disease of grass carp and feedstuff.
Background technology
In recent years, the fast development of breeding fish along with feedstuff, Ctenopharyngodon idellus (
c tenopha ryngodon idellus) because its efficiency of feed utilization is high, aquaculture cost is cheap, it is rapid, best in quality to grow, deeply like by broad masses, developed into the govern-house-variety of China's freshwater aquiculture.The frequent of research of hemorrhage of grass carp greatly reduces its survival rate, causes huge economic loss to raiser, thus has had a strong impact on the enthusiasm of numerous culturists.
Pathogen-the GCRV of hemorrhagic disease of grass carp, works as water quality deterioration, and dissolved oxygen is not enough, and transparency is low, and in water, ammonia nitrogen, hydrogen sulfide and Organic substance oxygen consumption are higher, and fish body is lower for the resistance, easy outbreak of epidemic during water temperature height.Its epidemic season is generally at the end of last ten-days period to 9 in June month, and August is epidemic peak season, and this disease mainly infects in the histiocyte of living in Liver of Ctenopharyngodon Idellus, heart, muscle, kidney, spleen, the gill, intestinal etc., causes chemicals to be difficult to reach therapeutic effect.At present, immunological technique has achieved certain effect in aquaculture diseases prevention and treatment.Therefore, the application of immunological technique also should be one of most effectively preventing method of hemorrhagic disease of grass carp.
Ctenopharyngodon idellus immunity comprises specific immunity and nonspecific immunity, and the leukocyte in blood circulation, phagocyte etc. and lymphocyte all participate in specific immunity; Lysozyme, superoxide dismutase, phenol oxidase, protease inhibitor, transfer factor, complement, proteins C reactive, chitinase, I type interferon etc. participate in nonspecific immunity.The immune factor of Ctenopharyngodon idellus is significant in immunoprotection.
Chinese herbal medicine has the advantages such as natural, efficient, toxic and side effects is few, aboundresources, is the substitute products of other forbidding antibiotics and chemicals, more and more receives publicity in aquaculture application.The research of recent domestic shows, Chinese medicine immunity enhancer can improve the non-specific immunity of aquatic animal.
Therefore, the present invention adopts Chinese herbal medicine as the Chinese medicine composition of control hemorrhagic disease of grass carp, relative to traditional Chinese medicine composition, has efficiently, toxic and side effects is little, safety is high, remains the plurality of advantages such as few, and source is wide, cost is low.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition for preventing and treating hemorrhagic disease of grass carp, adopts that this Chinese medicine composition has efficiently, toxic and side effects is little, safety is high, the residual plurality of advantages such as few, and source is wide, cost is low.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for preventing and treating hemorrhagic disease of grass carp, its crude drug comprises the Radix Astragali, Herba Epimedii, Fructus Lycii, Radix Sophorae Flavescentis, Herba Andrographis, Cacumen Platycladi, Rhizoma Coptidis, Radix Et Caulis Acanthopanacis Senticosi, Galla Chinensis, Herba Plantaginis, Spora Lygodii, Rhizoma Chuanxiong, Fructus Crataegi, Herba Menthae, Herba Artemisiae Scopariae, the Radix Pulsatillae, Herba Portulacae, Herba Dendrobii, Resina Ferulae, the Rhizoma Atractylodis Macrocephalae, Conyza japonica, Herba Alternantherae sessilis and Radix Glycyrrhizae.
Wherein, in described Chinese medicine composition, the weight of each crude drug is respectively Radix Astragali 70g ~ 80g, Herba Epimedii 30g ~ 40g, Fructus Lycii 50g ~ 60g, Radix Sophorae Flavescentis 25g ~ 35g, Herba Andrographis 30g ~ 40g, Cacumen Platycladi 20g ~ 30g, Rhizoma Coptidis 40g ~ 50g, Radix Et Caulis Acanthopanacis Senticosi 55g ~ 65g, Galla Chinensis 35g ~ 45g, Herba Plantaginis 25g ~ 35g, Spora Lygodii 30g ~ 40g, Rhizoma Chuanxiong 35g ~ 45g, Fructus Crataegi 30g ~ 40g, Herba Menthae 25g ~ 35g, Herba Artemisiae Scopariae 20g ~ 30g, Radix Pulsatillae 30g ~ 40g, Herba Portulacae 25g ~ 35g, Herba Dendrobii 30g ~ 40g, Resina Ferulae 25g ~ 35g, Rhizoma Atractylodis Macrocephalae 40g ~ 50g, Conyza japonica 25g ~ 35g, Herba Alternantherae sessilis 20g ~ 30g and Radix Glycyrrhizae 35g ~ 45g.
Wherein, in described Chinese medicine composition, the weight of each crude drug is respectively Radix Astragali 75g, Herba Epimedii 35g, Fructus Lycii 55g, Radix Sophorae Flavescentis 30g, Herba Andrographis 35, Cacumen Platycladi 25g, Rhizoma Coptidis 45g, Radix Et Caulis Acanthopanacis Senticosi 60g, Galla Chinensis 40g, Herba Plantaginis 30g, Spora Lygodii 35g, Rhizoma Chuanxiong 40g, Fructus Crataegi 35g, Herba Menthae 30g, Herba Artemisiae Scopariae 25g, Radix Pulsatillae 35g, Herba Portulacae 30g, Herba Dendrobii 35g, Resina Ferulae 30g, Rhizoma Atractylodis Macrocephalae 45g, Conyza japonica 30g, Herba Alternantherae sessilis 25g and Radix Glycyrrhizae 40g.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, be specially:
Each crude drug component in above-mentioned Chinese medicine composition is ground to form fine powder respectively, mixing, obtain mixture, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 3 ~ 5 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized, obtain Chinese medicine composition.
Present invention also offers a kind of feedstuff for preventing and treating hemorrhagic disease of grass carp, it comprises Borax, magnesium acetate, vitamin C, vitamin E, bean cake, fish flour, Sal, fish oil, wheat flour, Chinese medicine composition.
Wherein, in described feedstuff, the weight of each raw material is respectively Borax 20mg ~ 40mg, magnesium acetate 1g ~ 2g, vitamin C 50mg ~ 70mg, vitamin E 50mg ~ 70mg, bean cake 900g ~ 1100g, fish flour 50g ~ 70g, Sal 10g ~ 20g, fish oil 20g ~ 30g, wheat flour 200g ~ 300g, Chinese medicine composition 100g ~ 150g.
Wherein, in described feedstuff, the weight of each raw material is respectively Borax 30mg, magnesium acetate 1.5g, vitamin C 60mg, vitamin E 60mg, bean cake 1000g, fish flour 60g, Sal 15g, fish oil 25g, wheat flour 250g, Chinese medicine composition 120g.
The preparation method of the above-mentioned feedstuff that the present invention also provides, is specially:
The first step, each crude drug component in above-mentioned Chinese medicine composition is ground to form fine powder respectively, mixing, obtain mixture, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 3 ~ 5 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized, and add starch according to the ratio of mass ratio 1:3 ~ 5, mixing, granulate with 14 mesh sieves, toast 30 minutes in 60 DEG C ~ 70 DEG C baking ovens, obtain Chinese medicine feed additive,
Other each components in the Chinese medicine composition of first step acquisition and described feedstuff are sent into stirrer for mixing even, are sent in pulverizer subsequently and pulverize, cross 80 ~ 100 object screen clothes by second step in proportion;
3rd step; material after pulverizing is sent in quality-adjusting device; pass into the steam accounting for quality of material 15% ~ 20%; the temperature modulated 6 ~ 7 minutes of 90 ~ 100 DEG C; then the modulation products of acquisition is entered at the temperature of 95 ~ 100 DEG C extruding puffing granulator to granulate, under 90 ~ 103 DEG C of conditions, the feed granules after expanded is dried.
Beneficial effect of the present invention:
Chinese medicine composition provided by the invention has efficiently, toxic and side effects is little, safety is high, remain the plurality of advantages such as few, and source is wide, cost is low.
Detailed description of the invention
The invention provides a kind of Chinese medicine composition for preventing and treating hemorrhagic disease of grass carp, its crude drug comprises the Radix Astragali, Herba Epimedii, Fructus Lycii, Radix Sophorae Flavescentis, Herba Andrographis, Cacumen Platycladi, Rhizoma Coptidis, Radix Et Caulis Acanthopanacis Senticosi, Galla Chinensis, Herba Plantaginis, Spora Lygodii, Rhizoma Chuanxiong, Fructus Crataegi, Herba Menthae, Herba Artemisiae Scopariae, the Radix Pulsatillae, Herba Portulacae, Herba Dendrobii, Resina Ferulae, the Rhizoma Atractylodis Macrocephalae, Conyza japonica, Herba Alternantherae sessilis and Radix Glycyrrhizae.
Further preferably, described Chinese medicine composition is only made up of above-mentioned raw materials medicine.
In described Chinese medicine composition, the weight of each crude drug is respectively Radix Astragali 70g ~ 80g, Herba Epimedii 30g ~ 40g, Fructus Lycii 50g ~ 60g, Radix Sophorae Flavescentis 25g ~ 35g, Herba Andrographis 30g ~ 40g, Cacumen Platycladi 20g ~ 30g, Rhizoma Coptidis 40g ~ 50g, Radix Et Caulis Acanthopanacis Senticosi 55g ~ 65g, Galla Chinensis 35g ~ 45g, Herba Plantaginis 25g ~ 35g, Spora Lygodii 30g ~ 40g, Rhizoma Chuanxiong 35g ~ 45g, Fructus Crataegi 30g ~ 40g, Herba Menthae 25g ~ 35g, Herba Artemisiae Scopariae 20g ~ 30g, Radix Pulsatillae 30g ~ 40g, Herba Portulacae 25g ~ 35g, Herba Dendrobii 30g ~ 40g, Resina Ferulae 25g ~ 35g, Rhizoma Atractylodis Macrocephalae 40g ~ 50g, Conyza japonica 25g ~ 35g, Herba Alternantherae sessilis 20g ~ 30g and Radix Glycyrrhizae 35g ~ 45g.
Further preferably, in described Chinese medicine composition, the weight of each crude drug is respectively Radix Astragali 75g, Herba Epimedii 35g, Fructus Lycii 55g, Radix Sophorae Flavescentis 30g, Herba Andrographis 35, Cacumen Platycladi 25g, Rhizoma Coptidis 45g, Radix Et Caulis Acanthopanacis Senticosi 60g, Galla Chinensis 40g, Herba Plantaginis 30g, Spora Lygodii 35g, Rhizoma Chuanxiong 40g, Fructus Crataegi 35g, Herba Menthae 30g, Herba Artemisiae Scopariae 25g, Radix Pulsatillae 35g, Herba Portulacae 30g, Herba Dendrobii 35g, Resina Ferulae 30g, Rhizoma Atractylodis Macrocephalae 45g, Conyza japonica 30g, Herba Alternantherae sessilis 25g and Radix Glycyrrhizae 40g.
The pharmacology of each crude drug is as follows:
The Radix Astragali: sweet in the mouth, warm in nature, enter spleen, lung meridian, have benefit strengthening spleen and lung, elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, the effects such as holder skin ulcer granulation promoting, are mainly used in the weak anorexia and loose stool that deficiency of both the splenic and pulmonary QI is caused, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency, the cards such as insufficiency of vital energy and blood.
Herba Epimedii: latin name
epimedii Folium, acrid in the mouth, sweet, warm in nature, enter liver, kidney channel, there is kidney-replenishing, bone and muscle strengthening, effect of wind-damp dispelling, cure mainly that impotence due to deficiency of the kidney, seminal emission premature ejaculation, waist knee joint flaccidity are soft, cold extremities with aversion to cold; Arthralgia due to cold-dampnes or spasm of the limbs numbness wait card, and Herba Epimedii is traditional kidney invigorating and YANG supporting Chinese medicine, is rich in flavone compound, has gonadotropic Effect, directly suppression bone resorption and promoting bone growing, the positive balance state making organism metabolism be in bone formation to be greater than bone resorption.
Fructus Lycii: sweet in the mouth, property are flat, enter liver, kidney channel, have liver and kidney tonifying, nourish blood enrich blood, the effect of replenishing vital essence to improve eyesight, nourishing the lung to arrest cough, be mainly used in Liver and kidney two void, the soreness of the waist and knees of asthenia of essence and blood, dizziness and tinnitus, seminal emission tinnitus, unconsciously sweat and tire; The sexual impotence of insufficiency of kidney-YANG, sterile; The cards such as the dim-sighted and deficiency of YIN chronic cough of the eyes of deficiency of YIN-essence, deficiency of liver-blood, Fructus Lycii can promote liver cell regeneration, the effect of enhancing non-specific immunity function.
Radix Sophorae Flavescentis: latin name
sophorae Flavescentis Radix,bitter in the mouth, cold in nature, enter the heart, stomach, large intestine, urinary bladder channel, there is the effect of heat clearing and damp drying, wind dispelling insecticide, be mainly used in damp-heat dysentery, jaundice, stranguria, Radix Sophorae Flavescentis has obvious inhibitory action to dysentery bacterium, escherichia coli, Bacillus proteus, group B streptococcus and staphylococcus aureus.
Herba Andrographis: bitter in the mouth, cold in nature, GUIXIN, lung, large intestine, urinary bladder channel, have heat-clearing and toxic substances removing, removing heat from blood, and detumescence, effect of dampness, cures mainly cold, fever, laryngopharynx swelling and pain, aphtha of the mouth and tongue, pertussis chronic cough, dysentery, the puckery pain of pyretic stranguria, carbuncle skin infection, the cards such as venom.
Cacumen Platycladi: bitter in the mouth, puckery, cold in nature, return lung, liver, spleen channel, have cooling blood for hemostasis, preventing phlegm from forming and stopping coughing, effect of growing and blacking hair, cures mainly haematemesis, and hemoptysis is had blood in stool, bleeding not during menses, lung-heat cough with asthma, heat in blood alopecia, the cards such as early whitening of beard and hair.
Rhizoma Coptidis: bitter in the mouth, cold in nature, enters the heart, lung, gallbladder, stomach, large intestine channel, has the effect of heat clearing and damp drying, eliminating fire and detoxication, cooling blood for improving eyesight, be longer than the fire of removing pathogen in the heart stomach, have preventing or arresting vomiting concurrently to disappear the merit of painful abdominal mass, can be used for the prosperous caused dysphoria and insomnia for the treatment of heart-fire, and the high fever coma of epidemic febrile disease, vexed, thirsty; Also can be used for damp and hot caused dysentery, tenesmus; The cards such as pyretic toxicity carbuncle sore, eczema, aphtha of the mouth and tongue, epidemic hemorrhagic conjunctivitis.
Radix Et Caulis Acanthopanacis Senticosi: latin name
acanthopanacis Senticosi Radix et Rhizomaseu Caulis, acrid in the mouth, hardship, micro-sweet, warm in nature, enter spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, the card such as body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched.
Galla Chinensis: latin name
galla Chinensis,sour in the mouth, puckery, cold in nature, return lung, large intestine, kidney channel, there is effect of astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of convergence, kidney calming, cure mainly: chronic cough of deficiency lung; Spontaneous sweating; Chronic dysentery chronic diarrhea; Proctoptosis; Seminal emission; Nebulousurine; Various hemorrhage; The cards such as carbuncle furuncle, Galla Chinensis energy enhancing body, to the defence capability of nonspecific stimulation, can strengthen the immunologic function of cell, has inhibitory action to this pathogenic bacterium, and can antiviral growth.
Herba Plantaginis: latin name
plantaginis Herba, sweet in the mouth; Light; Cold nature, returns lung meridian; Liver Channel; Kidney channel; Urinary bladder channel, has clearing away heat and promoting diuresis; Eliminating dampness by diuresis antidiarrheal; Effect that improving eyesight is eliminated the phlegm, cures mainly dysuria; Stranguria with turbid discharge leukorrhagia; Edema distension; Heat-damp in summer dysentery; Conjunctival congestion is hidden from view; Expectorant heat syndrome cough such as to breathe heavily at the card.
Spora Lygodii: cold in nature, sweet in the mouth, returns bladder, and small intestine meridian has eliminating damp-heat, and effect for the treatment of stranguria pain relieving cures mainly the cards such as pyretic stranguria, sand Stranguria, stranguria with blood, stranguria marked by chyluria, Urethra astringent pain.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature, return liver, gallbladder, pericardium channel, have blood-activating and qi-promoting, the effect of wind-expelling pain-stopping, for menoxenia; Amenorrhea dysmenorrhea; The stagnant raw meat pain of the stasis of blood in puerperal; Lump in the abdomen lump; Pain in chest and hypochondrium; Have a headache dizzy; Anemofrigid-damp arthralgia; Traumatic injury; The cards such as ulcer sores.
Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature, returns spleen, stomach, Liver Channel, for promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, be mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, have loose bowels, dysentery, Fructus Crataegi be the staple for the treatment of dyspepsia, and Fructus Crataegi can increase the secretion of peptic digestion enzyme, facilitating digestion; To dysentery bacterium, escherichia coli, bacillus pyocyaneus, staphylococcus aureus etc., there is obvious inhibitory action, the effect that the effective ingredient Fructus Crataegi total flavones in Fructus Crataegi and Fructus Crataegi total triterpene acids have good blood fat reducing, reduce cholesterol, increase Gastric juice digestion enzyme.
Herba Menthae: latin name
menthae Haplocalycis Herba, acrid in the mouth, cool in nature, return lung, Liver Channel, there is dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, effect of dispersing the stagnated live-QI to relieve the stagnation of QI, cure mainly affection due to external wind and heat, epidemic febrile disease is shown in heating, micro-evil pain, headache, cough, headache due to pathogenic wind-heat, the many tear of conjunctival congestion, the cards such as laryngopharynx swelling and pain from the beginning of, disease.
Herba Artemisiae Scopariae: latin name
artemisiae Scopariae Herba, bitter in the mouth, pungent, cold nature, enters spleen, stomach, liver, gallbladder meridian, has clearing away damp-heat, the effect of jaundice eliminating subcutaneous ulcer, and for jaundice, no matter damp and hot YANG jaundice or cold-damp YIN jaundice all can be applied, and also can be applicable to the cards such as oliguria with reddish urine caused by fever disease in summer or hygropyrexia.
The Radix Pulsatillae: bitter in the mouth, cold in nature, enter stomach, large intestine channel, there is the effect of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, be mainly used in the intestines and stomach and have damp and hot stagnant heating stomachache, dysentery pus and blood, the treatment of the symptoms such as tenesmus, better to the hematodiarrhoea hematochezia effect of large intestine heat in blood, the Radix Pulsatillae all has certain inhibitory action to dysentery bacterium, Bacillus typhi, bacillus subtilis, escherichia coli, Staphyloccocus aureus.
Herba Portulacae: latin name
portulacae herba, sour in the mouth, cold in nature, return large intestine, Liver Channel, have heat-clearing and toxic substances removing, diuretic dries, loose blood detumescence, dust-collection sterilization, and anti-inflammatory analgetic, effect of hemostasis removing heat from blood, cure mainly dysentery, enteritis, nephritis, puerperal, metrorrhagia, had blood in stool, the diseases such as mastitis.
Herba Dendrobii: latin name
dendrobii Caulis, cold nature, sweet in the mouth, returns stomach, kidney channel, has reinforcing stomach reg fluid, effect of nourishing YIN and clearing away heat, and cure mainly cloudy impairment of body fluid and lose, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, the cards such as poor vision.
Resina Ferulae: bitter in the mouth, pungent, warm in nature, returns kidney, stomach warp, has removing food stagnancy, loose painful abdominal mass, effect of parasite killing, for meat stagnation, and blood stasis lump in the abdomen, mass in abdomen, the cards such as abdominal pain due to worm stagnation.
The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, have spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, the effect that activating the spleen is moisturized, be mainly used in the feeling of fullness diarrhoea that dysfunction of the spleen in transportation, QI failing to transform into body fluid are caused, phlegm retention edema; The vexed lazyness speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration.
Conyza japonica: bitter in the mouth, pungent, cold in nature, have clearing away heat to alleviate pain, effect of dispelling pathogenic wind and eliminating phlegm, cures mainly laryngitis, pneumonia, laryngopharynx swelling and pain, the cards such as tonsillitis.
Herba Alternantherae sessilis: sweet in the mouth, cold in nature, have cool the blood dissipate blood stasis, heat-clearing and toxic substances removing, dehumidify treating stranguria card such as grade, cures mainly hemoptysis, spit blood, have blood in stool, jaundice due to damp-heat, the cards such as dysentery, has loose bowels, gingival swelling and pain, laryngopharynx swelling and pain, acute mastitis, swollen ulcer drug, traumatic injury, venom.
Radix Glycyrrhizae: latin name
glycyrrhizae Radix et Rhizoma, sweet in the mouth, property put down, enter 12 warps, have heat-clearing and toxic substances removing, be in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak; Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play QI invigorating neutralization by adding Radix Glycyrrhizae, is in harmonious proportion the work of each component.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, be specially:
Each crude drug component in above-mentioned Chinese medicine composition is ground to form fine powder respectively, mixing, obtain mixture, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized, obtain Chinese medicine composition.
Present invention also offers a kind of feedstuff for preventing and treating hemorrhagic disease of grass carp, it comprises Borax, magnesium acetate, vitamin C, vitamin E, bean cake, fish flour, Sal, fish oil, wheat flour, Chinese medicine composition.
In described feedstuff, the weight of each raw material is respectively Borax 20mg ~ 40mg, magnesium acetate 1g ~ 2g, vitamin C 50mg ~ 70mg, vitamin E 50mg ~ 70mg, bean cake 900g ~ 1100g, fish flour 50g ~ 70g, Sal 10g ~ 20g, fish oil 20g ~ 30g, wheat flour 200g ~ 300g, Chinese medicine composition 100g ~ 150g.
Further preferably, in described feedstuff, the weight of each raw material is respectively Borax 30mg, magnesium acetate 1.5g, vitamin C 60mg, vitamin E 60mg, bean cake 1000g, fish flour 60g, Sal 15g, fish oil 25g, wheat flour 250g, Chinese medicine composition 120g.
The preparation method of the above-mentioned feedstuff that the present invention also provides, is specially:
The first step, each crude drug component in above-mentioned Chinese medicine composition is ground to form fine powder respectively, mixing, obtain mixture, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized, and add starch according to the ratio of mass ratio 1:3 ~ 5, mixing, granulate with 14 mesh sieves, toast 30 minutes in 60 DEG C ~ 70 DEG C baking ovens, obtain Chinese medicine feed additive,
Other each components in the Chinese medicine composition of first step acquisition and described feedstuff are sent into stirrer for mixing even, are sent in pulverizer subsequently and pulverize, cross 80 ~ 100 object screen clothes by second step in proportion;
3rd step; material after pulverizing is sent in quality-adjusting device; pass into the steam accounting for quality of material 15% ~ 20%; the temperature modulated 6 ~ 7 minutes of 90 ~ 100 DEG C; then the modulation products of acquisition is entered at the temperature of 95 ~ 100 DEG C extruding puffing granulator to granulate, under 90 ~ 103 DEG C of conditions, the feed granules after expanded is dried.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
The preparation of embodiment 1 Chinese medicine composition 1
By Radix Astragali 75g, Herba Epimedii 35g, Fructus Lycii 55g, Radix Sophorae Flavescentis 30g, Herba Andrographis 35, Cacumen Platycladi 25g, Rhizoma Coptidis 45g, Radix Et Caulis Acanthopanacis Senticosi 60g, Galla Chinensis 40g, Herba Plantaginis 30g, Spora Lygodii 35g, Rhizoma Chuanxiong 40g, Fructus Crataegi 35g, Herba Menthae 30g, Herba Artemisiae Scopariae 25g, Radix Pulsatillae 35g, Herba Portulacae 30g, Herba Dendrobii 35g, Resina Ferulae 30g, Rhizoma Atractylodis Macrocephalae 45g, Conyza japonica 30g, Herba Alternantherae sessilis 25g and Radix Glycyrrhizae 40g grinds to form fine powder respectively, mixing, obtain mixture, mixture is added in the water of 6kg and decoct, each decoction 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of 1.7kg is in the alcoholic solution of 90%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized, obtain Chinese medicine composition 1.
The preparation of embodiment 2 Chinese medicine composition 2
By Radix Astragali 70g, Herba Epimedii 30g, Fructus Lycii 50g, Radix Sophorae Flavescentis 25g, Herba Andrographis 30, Cacumen Platycladi 20g, Rhizoma Coptidis 40g, Radix Et Caulis Acanthopanacis Senticosi 55g, Galla Chinensis 35g, Herba Plantaginis 25g, Spora Lygodii 30g, Rhizoma Chuanxiong 35g, Fructus Crataegi 30g, Herba Menthae 25g, Herba Artemisiae Scopariae 20g, Radix Pulsatillae 30g, Herba Portulacae 25g, Herba Dendrobii 30g, Resina Ferulae 25g, Rhizoma Atractylodis Macrocephalae 40g, Conyza japonica 25g, Herba Alternantherae sessilis 20g and Radix Glycyrrhizae 35g grinds to form fine powder respectively, mixing, obtain mixture, mixture is added in the water of 5kg and decoct, each decoction 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of 1.5kg is in the alcoholic solution of 90%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized, obtain Chinese medicine composition 2.
The preparation of embodiment 3 Chinese medicine composition 3
By Radix Astragali 80g, Herba Epimedii 40g, Fructus Lycii 60g, Radix Sophorae Flavescentis 35g, Herba Andrographis 40, Cacumen Platycladi 30g, Rhizoma Coptidis 50g, Radix Et Caulis Acanthopanacis Senticosi 65g, Galla Chinensis 45g, Herba Plantaginis 35g, Spora Lygodii 40g, Rhizoma Chuanxiong 45g, Fructus Crataegi 40g, Herba Menthae 35g, Herba Artemisiae Scopariae 30g, Radix Pulsatillae 40g, Herba Portulacae 35g, Herba Dendrobii 40g, Resina Ferulae 35g, Rhizoma Atractylodis Macrocephalae 50g, Conyza japonica 35g, Herba Alternantherae sessilis 30g and Radix Glycyrrhizae 45g grinds to form fine powder respectively, mixing, obtain mixture, mixture is added in the water of 7kg and decoct, each decoction 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of 2kg is in the alcoholic solution of 90%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized, obtain Chinese medicine composition 3.
Feedstuff 1
By Borax 30mg, magnesium acetate 1.5g, vitamin C 60mg, vitamin E 60mg, bean cake 1000g, fish flour 60g, Sal 15g, fish oil 25g, wheat flour 250g, embodiment 1 prepare Chinese medicine composition 120g send into stirrer for mixing even, send in pulverizer subsequently and pulverize, cross 80 ~ 100 object screen clothes, material after pulverizing is sent in quality-adjusting device, pass into the steam accounting for quality of material 15% ~ 20%, the temperature modulated 6 ~ 7 minutes of 90 ~ 100 DEG C, then the modulation products of acquisition is entered at the temperature of 95 ~ 100 DEG C extruding puffing granulator to granulate, under 90 ~ 103 DEG C of conditions, the feed granules after expanded is dried, obtain feedstuff 1.
Feedstuff 2
By Borax 30mg, magnesium acetate 1.5g, vitamin C 60mg, vitamin E 60mg, bean cake 1000g, fish flour 60g, Sal 15g, fish oil 25g, it is even that wheat flour 250g sends into stirrer for mixing, send in pulverizer subsequently and pulverize, cross 80 ~ 100 object screen clothes, material after pulverizing is sent in quality-adjusting device, pass into the steam accounting for quality of material 15% ~ 20%, the temperature modulated 6 ~ 7 minutes of 90 ~ 100 DEG C, then the modulation products of acquisition is entered at the temperature of 95 ~ 100 DEG C extruding puffing granulator to granulate, under 90 ~ 103 DEG C of conditions, the feed granules after expanded is dried, obtain feedstuff 1.
Control experiment
Qingdao reservoir, area about 6 hm
2, mean depth is about 7 m (flood season), puts Ctenopharyngodon idellus winter sheet fingerling 50,000 tail in a suitable place to breed.JIUYUE starts the dead fish that falls ill on 9th, and every day, the quantity of dead fish was multiplied, and JIUYUE dead Ctenopharyngodon idellus on the 16th reaches tail more than 300.Pick up the Ctenopharyngodon idellus (about 250 g/ tail) of morbidity, diagnosis finds that grass carp intestinal is seriously congested, gently scrapes intestinal inwall without obscission, and the light or irregular colour of liver color, gollbladder dilation, slight gill rot, is diagnosed as Ctenopharyngodon idellus " enteritis type " hemorrhagic disease.This 50,000 tail Ctenopharyngodon idellus is divided into two groups, often organize 2.5 ten thousand tails, JIUYUE beginning 5 min quicklime 250 kg before feeding intake on the 17th carry out food field and splash, 1 time/d (now because reservoir level is too dark, be not easy to full storehouse to splash medicine), when water level decreasing was 3. 2 m to mean depth to JIUYUE on 19th, carry out full storehouse with 6 t quicklime to splash, within 17th, start to deliver feedstuff 1 at first group in JIUYUE simultaneously, 1 meal/sky, continuous 6 days, often eat 200kg, deliver feedstuff 2 for second group, 1 meal/sky, continuous 6 days, often eat 200kg, first group of dead quantity of the 1st day Ctenopharyngodon idellus after medication is 327 tails, 2nd day dead quantity 66 tail of Ctenopharyngodon idellus, 3rd day dead 13 tails, fish within 4th day, is not had to fall ill dead, there is not hemorrhagic disease of grass carp more afterwards, general mortality rate is 1.62%, second group of dead quantity of the 1st day Ctenopharyngodon idellus is 411 tails, after this mortality fish all there is every day, stopped to 12 days, general mortality rate is 37.63%.
From this experiment, Chinese medicine composition provided by the invention is adopted to have good curative effect in control hemorrhagic disease of grass carp.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (6)
1. for preventing and treating a Chinese medicine composition for hemorrhagic disease of grass carp, it is characterized in that: crude drug is made up of the Radix Astragali, Herba Epimedii, Fructus Lycii, Radix Sophorae Flavescentis, Herba Andrographis, Cacumen Platycladi, Rhizoma Coptidis, Radix Et Caulis Acanthopanacis Senticosi, Galla Chinensis, Herba Plantaginis, Spora Lygodii, Rhizoma Chuanxiong, Fructus Crataegi, Herba Menthae, Herba Artemisiae Scopariae, the Radix Pulsatillae, Herba Portulacae, Herba Dendrobii, Resina Ferulae, the Rhizoma Atractylodis Macrocephalae, Conyza japonica, Herba Alternantherae sessilis and Radix Glycyrrhizae;
In described Chinese medicine composition, the weight of each crude drug is respectively Radix Astragali 70g ~ 80g, Herba Epimedii 30g ~ 40g, Fructus Lycii 50g ~ 60g, Radix Sophorae Flavescentis 25g ~ 35g, Herba Andrographis 30g ~ 40g, Cacumen Platycladi 20g ~ 30g, Rhizoma Coptidis 40g ~ 50g, Radix Et Caulis Acanthopanacis Senticosi 55g ~ 65g, Galla Chinensis 35g ~ 45g, Herba Plantaginis 25g ~ 35g, Spora Lygodii 30g ~ 40g, Rhizoma Chuanxiong 35g ~ 45g, Fructus Crataegi 30g ~ 40g, Herba Menthae 25g ~ 35g, Herba Artemisiae Scopariae 20g ~ 30g, Radix Pulsatillae 30g ~ 40g, Herba Portulacae 25g ~ 35g, Herba Dendrobii 30g ~ 40g, Resina Ferulae 25g ~ 35g, Rhizoma Atractylodis Macrocephalae 40g ~ 50g, Conyza japonica 25g ~ 35g, Herba Alternantherae sessilis 20g ~ 30g and Radix Glycyrrhizae 35g ~ 45g.
2. Chinese medicine composition as claimed in claim 1, is characterized in that: in described Chinese medicine composition, the weight of each crude drug is respectively Radix Astragali 75g, Herba Epimedii 35g, Fructus Lycii 55g, Radix Sophorae Flavescentis 30g, Herba Andrographis 35, Cacumen Platycladi 25g, Rhizoma Coptidis 45g, Radix Et Caulis Acanthopanacis Senticosi 60g, Galla Chinensis 40g, Herba Plantaginis 30g, Spora Lygodii 35g, Rhizoma Chuanxiong 40g, Fructus Crataegi 35g, Herba Menthae 30g, Herba Artemisiae Scopariae 25g, Radix Pulsatillae 35g, Herba Portulacae 30g, Herba Dendrobii 35g, Resina Ferulae 30g, Rhizoma Atractylodis Macrocephalae 45g, Conyza japonica 30g, Herba Alternantherae sessilis 25g and Radix Glycyrrhizae 40g.
3. the preparation method of Chinese medicine composition described in claim 1 or 2, is characterized in that:
Each crude drug component in above-mentioned Chinese medicine composition is ground to form fine powder respectively, mixing, obtain mixture, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 3 ~ 5 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized, obtain Chinese medicine composition.
4. for preventing and treating a feedstuff for hemorrhagic disease of grass carp, it is characterized in that, comprising: Borax, magnesium acetate, vitamin C, vitamin E, bean cake, fish flour, Sal, fish oil, wheat flour, as claimed in claim 1 or 2 Chinese medicine composition.
5. feedstuff as claimed in claim 4, is characterized in that: in described feedstuff, the weight of each raw material is respectively Borax 20mg ~ 40mg, magnesium acetate 1g ~ 2g, vitamin C 50mg ~ 70mg, vitamin E 50mg ~ 70mg, bean cake 900g ~ 1100g, fish flour 50g ~ 70g, Sal 10g ~ 20g, fish oil 20g ~ 30g, wheat flour 200g ~ 300g, Chinese medicine composition 100g ~ 150g.
6. feedstuff as claimed in claim 5, is characterized in that: in described feedstuff, the weight of each raw material is respectively Borax 30mg, magnesium acetate 1.5g, vitamin C 60mg, vitamin E 60mg, bean cake 1000g, fish flour 60g, Sal 15g, fish oil 25g, wheat flour 250g, Chinese medicine composition 120g.
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| CN106562102A (en) * | 2016-10-20 | 2017-04-19 | 南宁海世界生物科技有限公司 | Traditional Chinese medicine feed additive for improving disease resistance of ctenopharyngodon idellus, and preparation method thereof |
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| CN106614154A (en) * | 2016-12-23 | 2017-05-10 | 江苏农林职业技术学院 | Method for preventing hemorrhage disease of grass carps |
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| CN110506837A (en) * | 2019-09-30 | 2019-11-29 | 江门海大饲料有限公司 | It is a kind of to prevent functional feed additive that grass carp irritability tail fin whitens and functional feed and application |
| CN112535126A (en) * | 2020-12-18 | 2021-03-23 | 岳西海富生态农业发展有限公司 | Optimized grass carp breeding method |
| CN115025117B (en) * | 2022-06-22 | 2023-06-20 | 中国科学院水生生物研究所 | Application of magnesium ions in preventing and treating aquatic virus infection |
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| CN102370101A (en) * | 2011-10-10 | 2012-03-14 | 淮安华威饲料发展有限公司 | Feed for preventing hemorrhage of grass carp under high-density feeding condition |
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