CN103656145B - Medicine being used for the treatment of pig lung plague and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of medicine being used for the treatment of pig lung plague and preparation method thereof, medicine comprises Radix Sophorae Tonkinensis, Lasiosphaera Seu Calvatia, Rhizoma Coptidis, Fructus Gardeniae, Radix Scutellariae, pollen, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, Radix Scrophulariae, Radix Gentianae, Caulis Akebiae, Fructus Forsythiae, Radix Platycodonis, Matrii Sulfas Exsiccatus, Bombyx Batryticatus, cup chrysanthemum, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Bulbus Fritillariae Thunbergii, Radix et Rhizoma Thalictri, Semen Arecae and Fructus Aristolochiae.The invention has the beneficial effects as follows: the present invention is based on heat-clearing and toxic substances removing, dispersing lung-QI and dissipating phlegm, with tonneau throat, anti-inflammatory analgetic be auxiliary provide treatment pig lung plague medicine, compare with Western medicine with Chinese medicine of the prior art, to the treatment of the pig suffering from pig lung plague have evident in efficacy, cure rate is high, side effect is little, not easily recur, advantage that cost is low.

Description

Medicine being used for the treatment of pig lung plague and preparation method thereof

Technical field

The present invention relates to herbal medicine technical field, particularly a kind of medicine being used for the treatment of pig lung plague and preparation method thereof.

Background technology

Pig lung plague is a kind of acute infectious disease (swine pasteurellosis) caused by multiple lethal pasteurellosis bacillus, is commonly called as " sore throat with dysphagia ", " swollen neck pestilence ".Acute or chronic process, the acute change in septicemia, bottleneck throat swelling, height dyspnea.Pasteurella multocida can infect many animals, and pig is wherein a kind of, and the pig at various age all can infection morbidity.It is generally acknowledged that this bacterium is a kind of conditionality pathogen, when pig is in bad external environment, as cold, sultry, weather drastic change, humidity, crowded, improper ventilation, malnutrition, fatigue, long-distance transport etc., cause the resistance of pig to decline, at this moment pathogen breeds in a large number and causes morbidity.Sick pig is through the discharge of bacteria such as secretions, Excreta in addition, and pollute drinking-water, feedstuff, apparatus and external environment, being transmitted to health pig through digestive tract, is also the important route of infection.Also cause of disease can be discharged, by the spittle through respiratory tract infection by cough, sneeze.In addition, hematophagus bites skin and mucosa wound all can infect.Primary disease is general without significantly seasonal, but to cold and heat succeed each other, climate variability, high temperature season is multiple, general in sporadic or endemicity.

To many animals with have pathogenic per capita, with the most susceptible of pig, occur without obviously seasonal, but to cold and heat succeed each other, weather drastic change, moist, rainy generation is more, and malnutrition, long-distance transport, rearing conditions change, the factor such as bad promotes that primary disease occurs, and often concentrate morbidity.

The most acute, acute and chronic type is divided into according to course of disease length and clinical manifestation.Most acute: do not occur any symptom, sudden onset, dead rapidly.The course of disease slightly elder shows body temperature and is elevated to 41 ~ 42 DEG C, and appetite is absolutely useless, and dyspnea, rapidly, visual mucosa cyanosis, purplish-red macula appears in skin in heart beating.Bottleneck throat and cervical region heating, red and swollen, hard, severe patient is extended down to the basal part of the ear, front.Sick pig breathes and is the devil, normal in sitting position of dog gesture, and extend head and neck, sometimes can send sound of stridulating, mouth and nose flow out white foam, sometimes with color.Once there is serious dyspnea, the state of an illness often worsens rapidly, very fast dead.Mortality rate Chang Gaoda 100%, spontaneous remission person is rare.Acute: this type is the most common.Body temperature is increased to 40 ~ 41 DEG C, and the initial stage is spastic dry cough, dyspnea, mouth and nose flow out foam, be sometimes mixed with blood, after become cough caused by pathogenic damp.With disease, breathe more difficult, often make sitting position of dog gesture, chest palpation has pain.Lassitude, inappetence or absolutely useless, there is erythema in skin, later stage languishment, does not rise sleepingly, how because of death by suffocation.The course of disease 5 ~ 8 days, the dead does not transfer to chronic.Chronic type: main manifestations is pneumonia and chronic gastroenteritis.Time have persistent cough and dyspnea, have fluid resistance or purulence nose liquid a little.Arthroncus, often has diarrhoea, inappetence, malnutrition, has crust sample eczema, grows and stops, skeletonize, the course of disease more than 2 weeks, and most generation is dead.

General incubation period is 1-5 days.Most acute, night is normal food also, and m seq and dead, often can't see reveal any symptoms, and the course of disease is slightly long, body temperature is elevated to 41-42 DEG C, and appetite is absolutely useless, and asthenia universalis, does not rise sleepingly, dyspnea, in sitting position of dog gesture, mouth and nose flow out foam, course of disease 1-2 day, mortality rate 100%.Acute (pleuropneumonia type), body temperature 40-41 DEG C, spastic dry cough, discharging sputum is mucus or purulence, dyspnea, and rear one-tenth is wet, pain is coughed, chest pain, and in dog, seat, dog crouch, first constipation, rear diarrhoea, visible congestive ecchymosis on skin.Chronic type, continues there is cough, dyspnea, and a small amount of mucus of nose stream, sometimes occurs arthroncus, become thin, diarrhoea, and dead through exhaustion in more than 2 weeks, the most acute and acute pig of case fatality rate 60-70%. shows as septicemia and pleuropneumonia.Affected pig portion is red and swollen, dyspnea, mucosa and skin cyanosis, body temperature 41-42 DEG C, course of disease 1-2 day.Chronic type is shown in persistent cough, dyspnea, and suppurating property nose liquid, becomes thin, exhaustion.Most acute: whole body mucosa, serous coat and subcutaneous tissue have petechia, especially with the hemorrhagic edema of larynx and surrounding tissue thereof for feature.Cut skin of neck, have the yellowish or grey cyan cellulosic serosity of a large amount of glue peptone sample.Lymph nodes of body as a whole swelling, hemorrhage.Visceral pericardium and pericardium there is petechia.Lung acute edema.Spleen has hemorrhage but not enlargement.Skin has ecchymosis.Bleeding of gastrointestinal mucosa inflammation.Acute: except having the pathological changes of most acute, its distinctive pathological changes is fibrinous pneumonia.Main manifestations is have volume foam mucus in trachea-bronchial epithelial cell.Lung has Gan Bian district in various degree, with edema due to disorder of QI and edema.Often have necrosis region in the Fei Ganbian district that the course of disease is long, between pulmonary lobule, serosity infiltrates, and lung tangent plane is marbleized appearance, and pleura has cellulosic attachment, pleura and sick adhesion of lung.Thoracic cavity and pericardial effusion.Chronic type: corpse skeletonize, anemia.Lungs You Ganbian district, and have yellow or Lycoperdon polymorphum Vitt necrosis region, there is connective tissue outside, includes caseous substance; Some formation cavities, communicate with bronchus.Pericardium and hydrothorax, thoracic cavity has cellulosic calm, and pleura is plump, usually with sick adhesion of lung.Sometimes see there is necrosis region at Intercostal muscle, peribronchial lymph node, mediastinal lymph nodes and tonsil, joint and subcutaneous tissue.Acute: except the hemorrhagic lesions of whole body mucosa, organa parenchymatosum, lymph node, distinctive pathological changes is fibrinous pneumonia, has Gan Bian district in various degree.Pleura and adhesion of lung, lung tangent plane is marble grain, thoracic cavity, pericardial effusion, and trachea-bronchial epithelial cell mucosa irritation has cystose mucus.Chronic type: Fei Ganbian district expands, has lark or Lycoperdon polymorphum Vitt necrosis, inside has caseous substance, and some formation cavities, highly become thin, anemia, subcutaneous tissue is shown in necrosis region.

Morbus acutissimus example, due to urgency of falling ill, often has little time treatment, sick pig dead.Penicillin, streptomycin and Cyclomycin family antibiotic have certain curative effect to pig lung plague.Antibiotic and sulphonamides share, as tetracycline+sulfadimidine, and tylosin+sulfadimidine.Special it is emphasized that this bacterium very easily develops immunity to drugs in treatment, therefore with good conditionsily should do drug sensitive test, select sensitive medicaments treatment.Prevention: the annual spring and autumn of (1) epidemic prevention regularly carries out twice immunity inoculation with pig lung plague aluminium hydroxide formaldehyde vaccine or the oral weak toadstool Seedling of pig lung plague.Also pig erysipelas, pig lung plague aluminium hydroxide Combined vaccine can be selected, the weak malicious trigeminy vaccine of swine fever, pig erysipelas, pig lung plague.Vaccination, a few days ago with in latter 7 days, forbids antibacterials.(2) improve feeding and management when conditions permit, advocate early weaning.Adopt the production routine of all-in and all-out; Enclosed swinery, reduces and draws pig from the outside; The measure such as density reducing swinery may can be helpful to control primary disease.(3) chemoprophylaxis is to regular incidence pig farm, will add antimicrobial drug and prevent in feedstuff.According to primary disease propagating characteristic, first anti-system answers the premunition of enhancing body.Strengthen feeding and management, elimination may reduce resistance against diseases factor and pathogenic inducement is as crowded in colony house, ventilation and lighting is poor, moist, catch cold.Colony house, environment are regularly sterilized.After new introduction pig quarantines one month, health can be gregarious.Carry out prophylactic immunization, be the important measures of prevention primary disease, regularly carry out planned inoculation every year.The pig lung plague vaccine of current production has pig lung plague inactivated vaccine, pig lung plague Inner Mongol is weak toadstool Seedling, pig lung plague eo-630 live vaccine, pig lung plague ta53 live vaccine, pig lung plague c20 live vaccine five kinds, use, preserve and points for attention by specification.When there is primary disease, sick pig should be isolated, block, tightly sterilize.With the pig on hurdle, promptly prevent with serum or with vaccine.Should isolate for treatment to distributing disease pig, sterilization pig house.To newly buy pig quarantine one month after the gregarious raising of change without exception.Treatment can adopt following medicine:

1, penicillin 80-240 ten thousand intramuscular injection, use 10% sulfadiazine 10-20 milliliters to inject with water 5-10 milliliters of intramuscular injection, 12 hours once, is used in conjunction 3 days simultaneously.

2, more than 45 kilograms pig 2500 milligrams, chloromycetin, streptomycin 3000 milligrams, the 20 milliliters of intramuscular injection of 10% aminophenazone, 6 hours 1 time, be used in conjunction 2 times.

3, gentamycin 1-2 mg/kg body weight, tetracycline 7-15 mg/kg body weight, every day 2 times, until temperature decline.

Western medicine easily develops immunity to drugs, and Chinese medicine has no side effect, without Drug resistance, its role is to, the QI and blood of conditioning human body, smooth the liver and regulate the spleen, the metabolic function of adjustment body and immunologic function, again there is antivirus action, therefore body recovery is fast, does not recur more, be that many veterinarian concentrated one's attention on the problem studied in recent years with herbal control pig lung plague.The Chinese medicine developed at present is good not as Western medicine to the treatment curative effect of pig lung plague, therefore has report Western medicine and Chinese medicine composition to be used, though it has the advantage of relative low price, effective speed is comparatively slow, just can make transference cure when medicine time is longer.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of medicine being used for the treatment of pig lung plague, overcomes the various defects of prior art Chinese medicine and western medicine and Chinese medicine, have evident in efficacy to the treatment suffering from pig lung plague, treating both the principal and secondary aspects of a disease, cure rate is high, and side effect is little, the advantage that cost is low.

In order to realize foregoing invention object, the invention provides a kind of medicine being used for the treatment of pig lung plague, described medicine comprises Radix Sophorae Tonkinensis, Lasiosphaera Seu Calvatia, Rhizoma Coptidis, Fructus Gardeniae, Radix Scutellariae, pollen, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, Radix Scrophulariae, Radix Gentianae, Caulis Akebiae, Fructus Forsythiae, Radix Platycodonis, Matrii Sulfas Exsiccatus, Bombyx Batryticatus, cup chrysanthemum, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Bulbus Fritillariae Thunbergii, Radix et Rhizoma Thalictri, Semen Arecae and Fructus Aristolochiae.

Described medicine is made up of the crude drug of following parts by weight: Radix Sophorae Tonkinensis 11 ~ 20 weight portion, Lasiosphaera Seu Calvatia 11 ~ 25 weight portion, Rhizoma Coptidis 11 ~ 45 weight portion, Fructus Gardeniae 10 ~ 16 weight portion, Radix Scutellariae 10 ~ 16 weight portion, pollen 10 ~ 15 weight portion, Fructus Aurantii Immaturus 10 ~ 15 weight portion, Radix Et Rhizoma Rhei 10 ~ 16 weight portion, Radix Scrophulariae 10 ~ 20 weight portion, Radix Gentianae 10 ~ 15 weight portion, Caulis Akebiae 10 ~ 15 weight portion, Fructus Forsythiae 10 ~ 20 weight portion, Radix Platycodonis 10 ~ 15 weight portion, Matrii Sulfas Exsiccatus 10 ~ 15 weight portion, Bombyx Batryticatus 10 ~ 15 weight portion, cup chrysanthemum 10 ~ 15 weight portion, Semen Lepidii (Semen Descurainiae) 10 ~ 15 weight portion, Fructus Perillae 10 ~ 20 weight portion, Bulbus Fritillariae Thunbergii 10 ~ 15 weight portion, Radix et Rhizoma Thalictri 10 ~ 15 weight portion, Semen Arecae 10 ~ 15 weight portion and Fructus Aristolochiae 10 ~ 15 weight portion.

Described medicine is preferably made up of the crude drug of following parts by weight: Radix Sophorae Tonkinensis 15 weight portion, Lasiosphaera Seu Calvatia 18 weight portion, Rhizoma Coptidis 29 weight portion, Fructus Gardeniae 13 weight portion, Radix Scutellariae 13 weight portion, pollen 12 weight portion, Fructus Aurantii Immaturus 12 weight portion, Radix Et Rhizoma Rhei 13 weight portion, Radix Scrophulariae 15 weight portion, Radix Gentianae 12 weight portion, Caulis Akebiae 13 weight portion, Fructus Forsythiae 15 weight portion, Radix Platycodonis 13 weight portion, Matrii Sulfas Exsiccatus 13 weight portion, Bombyx Batryticatus 12 weight portion, cup chrysanthemum 12 weight portion, Semen Lepidii (Semen Descurainiae) 13 weight portion, Fructus Perillae 15 weight portion, Bulbus Fritillariae Thunbergii 13 weight portion, Radix et Rhizoma Thalictri 12 weight portion, Semen Arecae 12 weight portion and Fructus Aristolochiae 13 weight portion.

Described medicine also comprises Semen coryli heterophyllae, Stigma Maydis, Folium Symplocoris Caudatae, rock wind and Radix Glycyrrhizae.

Described medicine is made up of the crude drug of following ratio of weight and number: Radix Sophorae Tonkinensis 15 ~ 20 weight portion, Lasiosphaera Seu Calvatia 12 ~ 25 weight portion, Rhizoma Coptidis 20 ~ 35 weight portion, Fructus Gardeniae 10 ~ 16 weight portion, Radix Scutellariae 10 ~ 16 weight portion, pollen 10 ~ 15 weight portion, Fructus Aurantii Immaturus 10 ~ 15 weight portion, Radix Et Rhizoma Rhei 10 ~ 16 weight portion, Radix Scrophulariae 11 ~ 15 weight portion, Radix Gentianae 11 ~ 15 weight portion, Caulis Akebiae 11 ~ 15 weight portion, Fructus Forsythiae 11 ~ 15 weight portion, Radix Platycodonis 11 ~ 15 weight portion, Matrii Sulfas Exsiccatus 10 ~ 15 weight portion, Bombyx Batryticatus 10 ~ 15 weight portion, cup chrysanthemum 11 ~ 15 weight portion, Semen Lepidii (Semen Descurainiae) 10 ~ 15 weight portion, Fructus Perillae 11 ~ 18 weight portion, Bulbus Fritillariae Thunbergii 11 ~ 15 weight portion, Radix et Rhizoma Thalictri 11 ~ 15 weight portion, Semen Arecae 11 ~ 15 weight portion, Fructus Aristolochiae 11 ~ 14 weight portion, Semen coryli heterophyllae 11 ~ 14 weight portion, Stigma Maydis 10 ~ 15 weight portion, Folium Symplocoris Caudatae 11 ~ 14 weight portion, rock wind 10 ~ 15 weight portion and Radix Glycyrrhizae 15 ~ 35 weight portion.

Described medicine is preferably made up of the crude drug of following ratio of weight and number: Radix Sophorae Tonkinensis 18 weight portion, Lasiosphaera Seu Calvatia 19 weight portion, Rhizoma Coptidis 32 weight portion, Fructus Gardeniae 13 weight portion, Radix Scutellariae 13 weight portion, pollen 12 weight portion, Fructus Aurantii Immaturus 12 weight portion, Radix Et Rhizoma Rhei 13 weight portion, Radix Scrophulariae 13 weight portion, Radix Gentianae 13 weight portion, Caulis Akebiae 12 weight portion, Fructus Forsythiae 13 weight portion, Radix Platycodonis 13 weight portion, Matrii Sulfas Exsiccatus 12 weight portion, Bombyx Batryticatus 12 weight portion, cup chrysanthemum 13 weight portion, Semen Lepidii (Semen Descurainiae) 13 weight portion, Fructus Perillae 15 weight portion, Bulbus Fritillariae Thunbergii 13 weight portion, Radix et Rhizoma Thalictri 13 weight portion, Semen Arecae 13 weight portion, Fructus Aristolochiae 12 weight portion, Semen coryli heterophyllae 13 weight portion, Stigma Maydis 12 weight portion, Folium Symplocoris Caudatae 13 weight portion, rock wind 13 weight portion and Radix Glycyrrhizae 25 weight portion.

In order to better realize foregoing invention object, the invention provides a kind of preparation method being used for the treatment of the medicine of pig lung plague, it is characterized in that, described preparation method comprises the following steps:

The first step, according to ratio of weight and number weighting raw materials material, after mixing, be ground into powder;

Second step, the first step obtained powder and add in cold water and soak 24 hours ~ 36 hours, with slow fire boiling, decocting time is 2 hours ~ 3 hours, decoction liquor is filtered, obtain the first filtrate, the quality of the water added is 3 ~ 5 times of the powder quality that the first step obtains;

3rd step, second step is filtered the filtering residue obtained again add in cold water, with slow fire boiling 2 ~ 4 times, each to decoct 1 hour ~ 2 hours, filter and merge filtrate, obtaining the second filtrate, the quality of the water added and identical in second step;

4th step, the first filtrate and the second filtrate merged, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, dry cream is put into spray dryer dry, ensure that inlet temperature is at 170 DEG C ~ 190 DEG C, leaving air temp 60 DEG C ~ 80 DEG C, be ground into 200 order ~ 400 orders subsequently, obtain drug powder.

The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: the present invention is based on heat-clearing and toxic substances removing, dispersing lung-QI and dissipating phlegm, with tonneau throat, anti-inflammatory analgetic be auxiliary provide treatment pig lung plague medicine, compare with Western medicine with Chinese medicine of the prior art, to the treatment of the pig suffering from pig lung plague have evident in efficacy, cure rate is high, side effect is little, not easily recur, advantage that cost is low.

Detailed description of the invention

According to clinical manifestation and course of disease process, the most acute, acute and chronic three types can be divided into.The most acute: not occur any symptom, sudden onset, dead rapidly.The course of disease slightly elder shows body temperature and is elevated to 41 ~ 42 DEG C, and appetite is absolutely useless, and dyspnea, rapidly, visual mucosa cyanosis, purplish-red macula appears in skin in heart beating.Bottleneck throat and cervical region heating, red and swollen, hard, severe patient is extended down to the basal part of the ear, front.Sick pig breathes and is the devil, normal in sitting position of dog gesture, and extend head and neck, sometimes can send sound of stridulating, mouth and nose flow out white foam, sometimes with color.Once there is serious dyspnea, the state of an illness often worsens rapidly, very fast dead.Mortality rate Chang Gaoda 100%, spontaneous remission person is rare.Acute: this type is the most common.Body temperature is increased to 40 ~ 41 DEG C, and the initial stage is spastic dry cough, dyspnea, mouth and nose flow out foam, be sometimes mixed with blood, after become cough caused by pathogenic damp.With disease, breathe more difficult, often make sitting position of dog gesture, chest palpation has pain.Lassitude, inappetence or absolutely useless, there is erythema in skin, later stage languishment, does not rise sleepingly, how because of death by suffocation.The course of disease 5 ~ 8 days, the dead does not transfer to chronic.Chronic type: main manifestations is pneumonia and chronic gastroenteritis.Time have persistent cough and dyspnea, have fluid resistance or purulence nose liquid a little.Arthroncus, often has diarrhoea, inappetence, malnutrition, has crust sample eczema, grows and stops, skeletonize, the course of disease more than 2 weeks, and most generation is dead.Chinese veterinarian thinks, pig lung plague is many catches a cold because feeding and management is bad and weather fusion is suffered from cold or suffers from other diseases, body healthy energy is impaired, defend outer ability to reduce, pathogenic factor invades lung through mouth and nose and defends, and heat evaporates poison so that qi depression to blood stasis, then pathogenic heat upper punch throat, so that pharyngitis burning pain, phlegm-fire is strongly fragrant in lung meridian, impairment of dispersing and descending function of the lung and cause QI rising in reverse order cough with asthma, dyspnea; Heat enters nutrient blood, then see skin erythema etc.Treatment pig lung plague disease should, based on heat-clearing and toxic substances removing, dispersing lung-QI and dissipating phlegm, be auxiliary with tonneau throat, anti-inflammatory analgetic.

According to above-mentioned theory and principle, the invention provides a kind of medicine being used for the treatment of pig lung plague, comprise Radix Sophorae Tonkinensis, Lasiosphaera Seu Calvatia, Rhizoma Coptidis, Fructus Gardeniae, Radix Scutellariae, pollen, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, Radix Scrophulariae, Radix Gentianae, Caulis Akebiae, Fructus Forsythiae, Radix Platycodonis, Matrii Sulfas Exsiccatus, Bombyx Batryticatus, cup chrysanthemum, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Bulbus Fritillariae Thunbergii, Radix et Rhizoma Thalictri, Semen Arecae and Fructus Aristolochiae.

The pharmacological property of each raw material is as follows:

Radix Sophorae Tonkinensis: bitter, cold; Poisonous.Attach to the lung and stomach meridians.Function cures mainly: heat-clearing and toxic substances removing, detumescence sore-throat relieving.Pent up for fire-toxin, laryngopharynx swelling and pain, gingivitis.

Lasiosphaera Seu Calvatia: pungent is flat.Function cures mainly: heat clearing away, sore-throat relieving, hemostasis.Cure mainly: pharyngolaryngitis, tonsillitis; Traumatic hemorrhage is controlled in external, bleeding hemorrhoids chilblain.

Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.The diseases such as, vomiting damp and hot for retention of damp-heat in the interior, the intestines and stomach, dysentery.Join Radix Scutellariae, Radix Et Rhizoma Rhei etc., the card of retention of damp-heat in the interior can be controlled.Be reluctant to leave the intestines and stomach to damp and hot, often coordinate the Rhizoma Pinelliae, Caulis Bambusae In Taenia; Join the Radix Aucklandiae, Radix Scutellariae, Radix Puerariae etc. to control dysentery.

Fructus Gardeniae: bitter in the mouth, cold in nature, enter the heart, lung, three burnt, have the effect of relieving restlessness pathogenic fire purging, dispersing the stagnated live-QI to relieve the stagnation of QI, clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, be mainly used in the vexed uneasiness of epidemic febrile disease heat stagnation breast gastral cavity, bother not peaceful; Stagnation of liver-QI is not relaxed or Liver Channel has having a dizzy spell of heat, pain in chest and hypochondrium, conjunctival congestion dry pharynx; Jaundice due to damp-heat; The symptoms such as the abdominal distention of qi depression to blood stasis, the burnt heat conduction of Fructus Gardeniae tonneau three is descending, and has anti-hepatic injury effect.

Radix Scutellariae: have heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are by the strong feature of broad-spectrum antibacterial action, are used in fungal culture miscellaneous bacteria and infect special severe, fine by Radix Scutellariae extracting solution effect." Bencao Jingshu ": Radix Scutellariae, its property is respectful clearly, so evil removing: bitter in the mouth is so dampness; YIN-cold is so victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, and the disease of all damp and hot victory also, analyses it, then all diseases are from recover.Bitter cold can except damp and hot, thus small intestinal profit and water from by, source is clearly then flowed also clean.The blood person of closing, excess-heat is at blood system, and instant heating human blood room, it is obstructed to make us amenorrhea, and damp and hot solution, then Ying Qi clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood then stays knot, and is that carbuncle stain is also rotten: acute scleritis person, also, removing heat from blood heat extraction, then spontaneous recovery also for fire of moxibustion blood trouble.

Pollen: sweet, micro-hardship, is slightly cold.Attach to the lung and stomach meridians.Clearing away heat and promoting production of body fluid, detumescence and apocenosis.For calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin." detailed outline ": radices trichosanthis, sweet and slightly bitter taste acid, acid can be promoted the production of body fluid, therefore profit of quenching the thirst is withered, and micro-bitter pathogenic fire reducing, does not sweetly injure one's stomach, and former times people only says its bitter cold, like deeply not examining." book on Chinese herbal medicine converge with speech ": Radix Trichosanthis, it is hot and suffocating to move back the five internal organs, and as heart-fire is contained and dry tongue and mouth, lung-fire is contained and pharyngeal swelling sore throat, and spleen-fire is contained and dispute tooth swells, and phlegm-fire is contained and cough is not peaceful.If the side of body of liver-fire is swollen migratory arthralgia caused by wind, the hectic fever due to YIN-deficiency dysphoria with smothery sensation of kidney fire, or carbuncle is not burst, and pyretic toxicity does not fall apart, or five types of jaundice yellow skin and eye, and if if little water drenches puckery, be caused by all burning hot pent-up, phlegm-fire, falls in only this agent energy relieving stagnation, and can control it.Its property is sweet cold again, kindly can control thirsty, and control empty thirsty from tonic, control fire from the medicine of a cold nature thirsty, control yearningly strongly fragrant from gas medicine, controlling excessive thirst from blood medicine, is control thirsty key medicine also.

Fructus Aurantii Immaturus: bitter, pungent, sour, temperature.Return spleen, stomach warp.Function cures mainly: dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm.Stop in stagnant, feeling of fullness distending pain, heavy after dysentery, constipation, the stagnant vapour lock thoracic obstruction of expectorant, blocked-up chest; Gastroptosis, proctoptosis, uterine prolapse.

Radix Et Rhizoma Rhei: cure mainly excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; Scald.

Radix Scrophulariae: sweet in the mouth, hardship, salty; Cold nature.Return lung, stomach, kidney channel.Clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing.Pathogenic warmth is joined the army, and cave in pericardium, maculae caused by violent heat pathogen, and consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin hinder constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.There is clearing away heat and cooling blood, removing toxic substances, eliminating stagnation sore-throat relieving, effect of YIN nourishing.To join the army for: warm febrile disease the card of blood, consumption of YIN caused by febrile disease.There is clearing away heat and cooling blood, effect of removing toxic substances YIN nourishing.

Radix Gentianae: bitter, cold.Return liver, gallbladder meridian.Function cures mainly: heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.For jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, conjunctival congestion, deaf, hypochondriac pain, bitter taste, convulsion with spasms.

Caulis Akebiae: bitter, be slightly cold.Enter heart channel, small intestine meridian, urinary bladder channel.There is the effect of clearing away heart-fire, diuresis, stimulating milk secretion of stimulating the menstrual flow.For irritable feverish sensation in the chest, sore throat pharyngalgia, dark coloured urine, five types of stranguria, edema, whole body spasm and pain, amenorrhea breast is few.The puckery pain of pyretic stranguria, edema.This product energy inducing diuresis to remove edema, lower dampness removing heat, makes that damp and hot heresy is descending discharges from urine.Treatment damp-heat in the urinary bladder, oliguria with reddish urine, drenches the puckery pain of drop, the normal and adapted such as Semen Plantaginis, Talcum; For edema, be then equipped with Polyporus, the equivalent use of Cortex Mori.Aphtha of the mouth and tongue, vexed dark coloured urine.The fire of this product energy supernatant heart channel, under let out the heat of small intestinal.Often control flaming up of heart-fire, aphtha of the mouth and tongue, or intestinal and the diseases such as the vexed dark coloured urine that causes under heart-fire moving downward, the adapteds such as many and Radix Rehmanniae, Radix Glycyrrhizae, Folium Bambusae.Amenorrhea breast is few.These product stimulate the menstrual flow stimulating milk secretion.With controlling blood stasis amenorrhea, join Flos Carthami, Semen Persicae, the equivalent use of Radix Salviae Miltiorrhizae; If deficient or obstructed with controlling milk, can being equal to Semen Vaccariae, Squama Manis and using; These product can also sharp blood vessels, get round by bribery, join Ramulus Mori, Semen Coicis is equal to use, treat damp and hot arthralgia pain.

Fructus Forsythiae: bitter in the mouth, cold nature, enters the heart, liver, gallbladder, small intestine meridian, have heat-clearing and toxic substances removing, the effect of dispersing swelling and dissipating binds, for carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly to join the army, high hot excessive thirst, coma sends out speckle, and the treatment of the card such as pyretic stranguria urine retention, has very strong inhibitory action to dysentery bacterium, staphylococcus aureus.

Radix Platycodonis: bitter in the mouth; Pungent; Property is put down.Return lung meridian.Effect: lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, fill blood, mend five kinds of over strain, foster the spirit of nobility.Cure mainly: cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.Energy expelling phlegm for arresting cough, and have lung qi dispersing, evacuation of pus effect.Contained platycodin is to the direct stimulation of oral cavity, throat, gastric mucosa, and reflexive ground increases bronchial mucosa hypersecretion thus sputum is diluted, and is easy to discharge; Radix Platycodonis has antitussive effect, and have and strengthen antiinflammatory and immunization, its antiinflammatory intensity is similar to aspirin; Water extract can strengthen the phagocytic function of macrophage, strengthens the sterilizing power of neutrophilic leukocyte, improves lysozyme activity; Preventive effect is had to stress ulcer.The thick saponin of Radix Platycodonis has calmness, analgesia, refrigeration function, again can blood sugar lowering, cholesterol reducing, relaxing smooth muscle.Platycodin has very strong haemolysis, but oral can decomposition in digestive tract destroys and lose haemolysis.

Matrii Sulfas Exsiccatus: salty, bitter, cold.Return stomach, large intestine channel.Function cures mainly: purging heat to relax the bowels, moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat.For excess-heat constipation, constipation due to dry stool, stagnant stomachache; External treatment laryngopharynx swelling and pain, aphtha of the mouth and tongue, gingival swelling and pain, conjunctival congestion, carbuncle, erysipelas.

Bombyx Batryticatus: acrid in the mouth; Salty; Property is put down.Return liver; Lung; Stomach warp.Function cures mainly: expelling wind and relieving convulsion; Dissipating phlegm and resolving masses; Resolving toxin and disinhibiting the throat.The main chronic ulcerated twitch;In tuyere slanting eyes oblique;S headaches;Sore throat;Scrofula.Mumps;Rubella;Chuangdu.1. anticonvulsant action: 10% decocting liquid 2g/kg, to Mouse oral, has obvious antagonism to the convulsions that strychnine nitrate causes.The mixture (i.e. the decoct of five brave Chinese medicine Zhuifengsans) be made up of commercially available Bombyx Batryticatus, Periostracum Cicadae etc. can reduce strychnine, pentetrazole, cocaine, and nicotine etc. cause the death toll of mice convulsion.Artificial Bombyx Batryticatus decoct also has the effect of the mice convulsion of antagonism caused by strychnine.2. syngignoscism: alcohol water-leach liquor has syngignoscism to mice and rabbit, Mouse oral 0.5g/20g, subcutaneous injection 0.25g/20g, approximate the hypodermic hypnosis effect of 50mg/kg phenobarbital.3. the pharmacological action of Bombyx Batryticatus: the convulsions that Bombyx Batryticatus antagonism white mice is caused by strychnine nitrate, effect is obvious, and result is consistent with Bombyx Batryticatus.In reduction mortality rate, test group and matched group difference not obvious, but Bombyx Batryticatus is consistent with the result of Bombyx Batryticatus.In two results, Bombyx Batryticatus is all slightly better than Bombyx Batryticatus.In addition, Bombyx Batryticatus still can suppress white mice S-180 (need affirm further), though have inhibitory action, DeGrain to staphylococcus aureus, escherichia coli, bacillus pyocyaneus etc.Due to, Bombyx Batryticatus convenient sources, therefore can in order to replace Bombyx Batryticatus.4. the pharmacological research of Bombycis mori: the toxicity of Bombycis mori is very low.Immature male Mouse Weight is increased and has facilitation, obviously can increase prostate one Seminal vesicle of castration mouse and castrated rats, the weight of preputial glands, show that there is androgen-like action.

Cup chrysanthemum: heat-clearing and toxic substances removing, anti-inflammation hemostasia, dehumidifying diuresis, parasite killing.Cure mainly acute gastroenteritis, heatstroke, cystitis, urethritis, pharyngolaryngitis, stomatitis, spit blood, epistaxis.

Semen Lepidii (Semen Descurainiae): pungent, bitter, Great Cold.Return lung, urinary bladder channel.Function cures mainly: eliminating pathogen from the lung for relieving asthma, line water detumescence.Stop up lung for sputum, dyspnea and cough with excessive sputum, fullness and distention in the chest and hypochondrium, must not put down sleeping, and ascites pleural fluid swells, dysuria; Pulmonary heart disease edema.

Fructus Perillae: pungent, temperature.Return lung, large intestine channel.Function cures mainly: sending down the abnormal ascending QI expectorant, relieving cough and asthma, loosening bowel to relieve constipation.QI rising in reverse order is stopped up, cough and asthma, dryness of the intestine constipation for expectorant.Pharmacological action: 1, to the effect of blood fat, feeds chicken with the feedstuff containing perilla oil, chicken plasma cholesterol levels can be made to reduce, but act on without this mice, and causes mice cervical region to lose hair or feathers and skin lesion; Feed rabbit with the feedstuff containing perilla oil, its body weight and liver weight can be increased, but the cholesterol level of blood plasma and liver is had no significant effect.2, bacteriostasis: experiment shows: the mycete of perilla oil (0.1%) to Bacillus proteus, Aspergillus niger, penicillium and occurring in nature all has inhibitory action. wherein to the effect obviously strong nipalgin of what 0.05% and the benzoic acid of 0.3% of yeast and mold.3, anticorrosion, antioxidation: the ethanol extraction of Fructus Perillae after defat has anticorrosion and antioxidation.The long storage periods of available what food and medicine. the BHT of its antioxidation compared with 0.02% (2,6-di-t-butyl p-Hydroxybenzylalcohol) is strong.

Bulbus Fritillariae Thunbergii: bitter, cold.Return lung, heart channel.Function cures mainly: heat clearing away eliminating stagnation, preventing phlegm from forming and stopping coughing, for wind-heat invading the lung, and phlegm-fire cough, lung abscess, acute mastitis, scrofula, sore.

Radix et Rhizoma Thalictri: bitter, cold.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.For enteritis, dysentery, jaundice, conjunctival congestion and swelling pain.

Semen Arecae: bitter in the mouth; Pungent; Warm in nature.Return stomach; Large intestine channel.Effect, anthelmintic; Removing food stagnancy; The therapeutic method to keep the adverse QI flowing downwards; Row water; Preventing the attack (or recurrence) of malaria.Malnutrition due to parasitic infestation; Dyspepsia; Abdominal distention; Heavy after dysentery; Foot gas; Edema; Malaria.Resisting pathogenic microbes effect Semen Arecae infusion (1:1) in vitro to trichophyton, permitted the dermatophytes such as blue achorion and had inhibitory action in various degree.Decoct and some strain of water logging agent infected by influenza A type have certain inhibitory action, and antiviral effect may be relevant with wherein contained tannin.

Fructus Aristolochiae: have lung heat clearing sending down the abnormal ascending QI, relieving cough and asthma, effect that bowel relieving disappears hemorrhoid, its stem claims Herba Aristolochiae to have to regulate the flow of vital energy, damp eliminating, promoting blood circulation and stopping pain effect, its root claims Radix Aristolochiae to have effect of promoting the circulation of QI to relieve pain, removing toxic substances and promoting subsidence of swelling.

Medicine of the present invention preferably also comprises: Semen coryli heterophyllae, Stigma Maydis, Folium Symplocoris Caudatae, rock wind and Radix Glycyrrhizae.

Semen coryli heterophyllae: sweet is flat.1. " Kaibao Bencao ": " sweet in the mouth is flat, nontoxic." 2. " medical center bun is wanted ": " is sweet salty, flat." function cures mainly: in tune, appetizing, improving eyesight.1. Cui Yu stannum " cuisine canon ": " three worms are gone in the improving eyesight of food." 2. " Japan hanako materia medica ": " fertile white man, only hungry, in tune, appetizing." 3. " Kaibao Bencao ":, " main physical strength profiting, wide the intestines and stomach make us not hungry, hike."

Stigma Maydis: sweet, light is flat.Return bladder, liver, gallbladder meridian.Function cures mainly: inducing diuresis to remove edema, suppressing the hyperactive liver function of gallbladder promoting.For acute and chronic nephritis, edema, acute hepatitis, chronic hepatitis, hypertension, diabetes, chronic sinusitis, lithangiuria, Biliary Calculi, the disease such as dysuria, damp and hot jaundice.And can habitual abortion be prevented.

Folium Symplocoris Caudatae: pungent, micro-hardship is cool.Function cures mainly: heat-clearing and toxic substances removing, eliminating stasis to stop pain.For cold, fever, toothache, menoxenia, infantile eczema; Furuncle toxic swelling is controlled in external, traumatic injury.

Rock wind: bitter; Cool.Function cures mainly: relieving stranguria by diuresis; Heat-clearing and toxic substances removing.Main stranguria; Edema; Acute mastitis; Sore

Radix Glycyrrhizae: property is put down, and sweet in the mouth, returns 12 warps.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strongly have removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic so that the pharmacological action such as anticancer, Radix Glycyrrhizae has blood fat reducing, antioxidative effect.

Embodiment 1 medicine 1

Embodiments provide a kind of medicine being used for the treatment of pig lung plague, medicine is made up of the raw material of following parts by weight: Radix Sophorae Tonkinensis 15 weight portion, Lasiosphaera Seu Calvatia 18 weight portion, Rhizoma Coptidis 29 weight portion, Fructus Gardeniae 13 weight portion, Radix Scutellariae 13 weight portion, pollen 12 weight portion, Fructus Aurantii Immaturus 12 weight portion, Radix Et Rhizoma Rhei 13 weight portion, Radix Scrophulariae 15 weight portion, Radix Gentianae 12 weight portion, Caulis Akebiae 13 weight portion, Fructus Forsythiae 15 weight portion, Radix Platycodonis 13 weight portion, Matrii Sulfas Exsiccatus 13 weight portion, Bombyx Batryticatus 12 weight portion, cup chrysanthemum 12 weight portion, Semen Lepidii (Semen Descurainiae) 13 weight portion, Fructus Perillae 15 weight portion, Bulbus Fritillariae Thunbergii 13 weight portion, Radix et Rhizoma Thalictri 12 weight portion, Semen Arecae 12 weight portion and Fructus Aristolochiae 13 weight portion.

The preparation method of medicine comprises the following steps:

The first step, according to ratio of weight and number weighting raw materials material, after mixing, be ground into powder;

Second step, the first step obtained powder and add in cold water and soak 36 hours, with slow fire boiling, decocting time is 2.5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 4 times of the powder quality that the first step obtains;

3rd step, second step is filtered the filtering residue obtained again add in cold water, with slow fire boiling 3 times, each to decoct 1 hour, filter and merge filtrate, obtaining the second filtrate, the quality of the water added and identical in second step;

4th step, the first filtrate and the second filtrate merged, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, and ensure that inlet temperature is at 180 DEG C, leaving air temp 70 DEG C, is ground into 300 orders subsequently, obtains drug powder.

Embodiment 2 medicine 2

The embodiment of the present invention 2 provides a kind of medicine being used for the treatment of pig lung plague, medicine comprises the raw material of following parts by weight: Radix Sophorae Tonkinensis 18 weight portion, Lasiosphaera Seu Calvatia 19 weight portion, Rhizoma Coptidis 32 weight portion, Fructus Gardeniae 13 weight portion, Radix Scutellariae 13 weight portion, pollen 12 weight portion, Fructus Aurantii Immaturus 12 weight portion, Radix Et Rhizoma Rhei 13 weight portion, Radix Scrophulariae 13 weight portion, Radix Gentianae 13 weight portion, Caulis Akebiae 12 weight portion, Fructus Forsythiae 13 weight portion, Radix Platycodonis 13 weight portion, Matrii Sulfas Exsiccatus 12 weight portion, Bombyx Batryticatus 12 weight portion, cup chrysanthemum 13 weight portion, Semen Lepidii (Semen Descurainiae) 13 weight portion, Fructus Perillae 15 weight portion, Bulbus Fritillariae Thunbergii 13 weight portion, Radix et Rhizoma Thalictri 13 weight portion, Semen Arecae 13 weight portion, Fructus Aristolochiae 12 weight portion, Semen coryli heterophyllae 13 weight portion, Stigma Maydis 12 weight portion, Folium Symplocoris Caudatae 13 weight portion, rock wind 13 weight portion and Radix Glycyrrhizae 25 weight portion.

The preparation method of medicine comprises the following steps:

The first step, according to ratio of weight and number weighting raw materials material, after mixing, be ground into powder;

Second step, the first step obtained powder and add in cold water and soak 30 hours, with slow fire boiling, decocting time is 3 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 5 times of the powder quality that the first step obtains;

3rd step, second step is filtered the filtering residue obtained again add in cold water, with slow fire boiling 2 times, each to decoct 2 hours, filter and merge filtrate, obtaining the second filtrate, the quality of the water added and identical in second step;

4th step, the first filtrate and the second filtrate merged, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, and ensure that inlet temperature is at 190 DEG C, leaving air temp 80 DEG C, is ground into 400 orders subsequently, obtains drug powder.

Acute toxicity test

Application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The medicine dissolution prepared by embodiments of the invention 1 is in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32.9 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>32.9 crude drug/kg of the present invention, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.073g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage Chinese medicine of the present invention is 901 times of quantity.Therefore the acute toxicity of the embodiment of the present invention 1 medicine is low, clinical drug safety.With the test method that the medicine of the embodiment of the present invention 2 is identical for object adopts, result proves that the acute toxicity of embodiment 2 medicine is low equally, clinical drug safety.

Long term toxicity test

The embodiment of the present invention 1 medicine presses 10.78,20.35 and 33.48g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of medicine to mice of the embodiment of the present invention 1 all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that the medicine of the embodiment of the present invention 1 is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.With the test method that the medicine of the embodiment of the present invention 2 is identical for object adopts, result proves that the medicine of embodiment 2 is little to toxicity after mice long-term prescription equally, does not also have difference reaction, application safety after drug withdrawal.

Clinical trial

1.1 for examination material

1.1.1 for examination animal

In 225 the healthy growing and fattening pigs of pig farm, Qingdao, Shandong Province random selecting, as experiment pig.

1.1.2 for prelibation strain

Pig pasteurellosis bacillus C44-41 and standard thereof resist clear, are provided by China Veterinary Drugs Supervisory Inst., cultivate voluntarily before infecting with broth bouillon.

1.1.3 medicine

Medicine 1 prepared by embodiment 1, is mixed in feedstuff according to the 5-10% of feedstuff gross weight; Medicine 2 prepared by embodiment 2, is mixed in feedstuff according to the 5-10% of feedstuff gross weight; Penicillin 80-240 ten thousand+10% sulfadiazine injection.

1.2 test method

1.2.1 inoculation test

Inject after cultured pig pasteurellosis bacillus C44-41 meat soup respectively ear, infective dose is 12.6 bacterium/kg.w.Infect in latter five days and have 220 pigs to occur pig lung plague symptom, select 180 ill pigs as experiment pig.

1.2.2 grouping is tested

180 ill piglets are divided into three groups at random, often organize 60, i.e. embodiment group 1, embodiment group 2 and matched group.

1.2.3 test method

Occur after infection that the pig of pig lung plague adopts different Therapeutic Method respectively, wherein, embodiment group 1 uses the embodiment of the present invention 1 Drug therapy, medicine is mixed in feedstuff, conventionally feed, each mixed volume is the 5-10% of feedstuff gross weight, uses three days continuously; Embodiment group 2 uses the embodiment of the present invention 2 Drug therapy, is mixed into by medicine in feedstuff, conventionally feeds, and each mixed volume is the 5-10% of feedstuff gross weight, uses three days continuously; Matched group uses penicillin 80-240 ten thousand intramuscular injection, and inject with the intramuscular injection of water 5-10 milliliter with 10% sulfadiazine 10-20 milliliter, 12 hours once, is used in conjunction 3 days simultaneously.

1.2.4 observed and recorded

Observe clinical symptoms and the pathological change of each group of ill pig after counteracting toxic substances, and compare its order of severity, record infects rear death toll, within three days, treats the therapeutic effect after terminating.

2 results

2.1 criterion of therapeutical effect

Cure: ill temperature of pig body, body colour, breathing, appetite all recover normal, cough, diarrhoea, edema phenomenon disappear;

Effective: ill temperature of pig body, body colour, breathing, appetite progressively recover normal, cough, diarrhoea, edema alleviate;

Invalid: ill pig symptom is not alleviated, and even increases the weight of death.

2.2 observed results are as shown in table 1.

Data from table 1: compared with matched group, the treatment of medicine to pig lung plague of the embodiment of the present invention 1 and embodiment 2 has evident in efficacy, and side effect is low, the advantage that treated effect is high; Find in long-term observation subsequently, embodiment group 1 and embodiment group 2 pig of curing again sickness rate is starkly lower than the pig of matched group.

After 2.3 counteracting toxic substances symptom with cut open inspection result

After counteracting toxic substances, the symptom of ill pig is: body temperature is elevated to more than 41 DEG C, and inappetence or absolutely useless, dyspnea, purplish-red macula appears in skin.Dead sick pig after infection is dissected, finds that whole body mucosa, serous coat and subcutaneous tissue have petechia, larynx and surrounding tissue hemorrhagic edema thereof, swollen lymph node, gastrointestinal mucosa hemorrhagic inflammation, indivedual pig lungs You Ganbian district, and have yellow or Lycoperdon polymorphum Vitt necrosis region.

Concrete case

Case 1

Certain raiser raises growing and fattening pigs 121 altogether, and November in 2012,1 growing and fattening pigs sudden onset was dead, and other pigs all have pig lung plague symptom in various degree, expiratory dyspnea, cervical region edema, and purple erythema appears in skin.Dead pig dissected and find that there is petechia in dead Corii Sus domestica undertissue, larynx and surrounding tissue hemorrhagic edema thereof, gastric bleeding is red and swollen, is diagnosed as swinery and suffers from pig lung plague.Use the embodiment of the present invention 1 medicine 1 to treat, medicine is mixed in feedstuff, conventionally feeds, each mixed volume is 8% of feedstuff gross weight, and after using three days continuously, 163 ill pigs recover normal, 37 ill pigs continue to feed and add the feedstuff two days of medicine 1, also all recover normal.

Case 2

Certain self-employed entrepreneurs that raises pigs feeds growing and fattening pigs 10, because pigsty is moist, heat, impels pathogenic bacteria to spread rapidly, 10 pigs are caused to occur that body temperature is elevated to more than 41 DEG C, inappetence or absolutely useless, dyspnea, there is the symptom such as purplish-red macula, cervical region edema in skin, is diagnosed as pig lung plague.Use the embodiment of the present invention 2 medicine 2 to treat, be mixed into by medicine in feedstuff, conventionally feed, each mixed volume is 6% of feedstuff gross weight, and after using three days continuously, 10 ill pigs all recover normal.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (5)

1. be used for the treatment of the medicine of pig lung plague, it is characterized in that, described medicine is made up of the crude drug of following parts by weight: Radix Sophorae Tonkinensis 11 ~ 20 weight portion, Lasiosphaera Seu Calvatia 11 ~ 25 weight portion, Rhizoma Coptidis 11 ~ 45 weight portion, Fructus Gardeniae 10 ~ 16 weight portion, Radix Scutellariae 10 ~ 16 weight portion, pollen 10 ~ 15 weight portion, Fructus Aurantii Immaturus 10 ~ 15 weight portion, Radix Et Rhizoma Rhei 10 ~ 16 weight portion, Radix Scrophulariae 10 ~ 20 weight portion, Radix Gentianae 10 ~ 15 weight portion, Caulis Akebiae 10 ~ 15 weight portion, Fructus Forsythiae 10 ~ 20 weight portion, Radix Platycodonis 10 ~ 15 weight portion, Matrii Sulfas Exsiccatus 10 ~ 15 weight portion, Bombyx Batryticatus 10 ~ 15 weight portion, cup chrysanthemum 10 ~ 15 weight portion, Semen Lepidii (Semen Descurainiae) 10 ~ 15 weight portion, Fructus Perillae 10 ~ 20 weight portion, Bulbus Fritillariae Thunbergii 10 ~ 15 weight portion, Radix et Rhizoma Thalictri 10 ~ 15 weight portion, Semen Arecae 10 ~ 15 weight portion and Fructus Aristolochiae 10 ~ 15 weight portion.

2. the medicine being used for the treatment of pig lung plague according to claim 1, it is characterized in that, described medicine is made up of the crude drug of following parts by weight: Radix Sophorae Tonkinensis 15 weight portion, Lasiosphaera Seu Calvatia 18 weight portion, Rhizoma Coptidis 29 weight portion, Fructus Gardeniae 13 weight portion, Radix Scutellariae 13 weight portion, pollen 12 weight portion, Fructus Aurantii Immaturus 12 weight portion, Radix Et Rhizoma Rhei 13 weight portion, Radix Scrophulariae 15 weight portion, Radix Gentianae 12 weight portion, Caulis Akebiae 13 weight portion, Fructus Forsythiae 15 weight portion, Radix Platycodonis 13 weight portion, Matrii Sulfas Exsiccatus 13 weight portion, Bombyx Batryticatus 12 weight portion, cup chrysanthemum 12 weight portion, Semen Lepidii (Semen Descurainiae) 13 weight portion, Fructus Perillae 15 weight portion, Bulbus Fritillariae Thunbergii 13 weight portion, Radix et Rhizoma Thalictri 12 weight portion, Semen Arecae 12 weight portion and Fructus Aristolochiae 13 weight portion.

3. be used for the treatment of the medicine of pig lung plague, it is characterized in that, described medicine is made up of the crude drug of following parts by weight: Radix Sophorae Tonkinensis 15 ~ 20 weight portion, Lasiosphaera Seu Calvatia 12 ~ 25 weight portion, Rhizoma Coptidis 20 ~ 35 weight portion, Fructus Gardeniae 10 ~ 16 weight portion, Radix Scutellariae 10 ~ 16 weight portion, pollen 10 ~ 15 weight portion, Fructus Aurantii Immaturus 10 ~ 15 weight portion, Radix Et Rhizoma Rhei 10 ~ 16 weight portion, Radix Scrophulariae 11 ~ 15 weight portion, Radix Gentianae 11 ~ 15 weight portion, Caulis Akebiae 11 ~ 15 weight portion, Fructus Forsythiae 11 ~ 15 weight portion, Radix Platycodonis 11 ~ 15 weight portion, Matrii Sulfas Exsiccatus 10 ~ 15 weight portion, Bombyx Batryticatus 10 ~ 15 weight portion, cup chrysanthemum 11 ~ 15 weight portion, Semen Lepidii (Semen Descurainiae) 10 ~ 15 weight portion, Fructus Perillae 11 ~ 18 weight portion, Bulbus Fritillariae Thunbergii 11 ~ 15 weight portion, Radix et Rhizoma Thalictri 11 ~ 15 weight portion, Semen Arecae 11 ~ 15 weight portion, Fructus Aristolochiae 11 ~ 14 weight portion, Semen coryli heterophyllae 11 ~ 14 weight portion, Stigma Maydis 10 ~ 15 weight portion, Folium Symplocoris Caudatae 11 ~ 14 weight portion, rock wind 10 ~ 15 weight portion and Radix Glycyrrhizae 15 ~ 35 weight portion.

4. the medicine being used for the treatment of pig lung plague according to claim 3, it is characterized in that, described medicine is made up of the crude drug of following ratio of weight and number: Radix Sophorae Tonkinensis 18 weight portion, Lasiosphaera Seu Calvatia 19 weight portion, Rhizoma Coptidis 32 weight portion, Fructus Gardeniae 13 weight portion, Radix Scutellariae 13 weight portion, pollen 12 weight portion, Fructus Aurantii Immaturus 12 weight portion, Radix Et Rhizoma Rhei 13 weight portion, Radix Scrophulariae 13 weight portion, Radix Gentianae 13 weight portion, Caulis Akebiae 12 weight portion, Fructus Forsythiae 13 weight portion, Radix Platycodonis 13 weight portion, Matrii Sulfas Exsiccatus 12 weight portion, Bombyx Batryticatus 12 weight portion, cup chrysanthemum 13 weight portion, Semen Lepidii (Semen Descurainiae) 13 weight portion, Fructus Perillae 15 weight portion, Bulbus Fritillariae Thunbergii 13 weight portion, Radix et Rhizoma Thalictri 13 weight portion, Semen Arecae 13 weight portion, Fructus Aristolochiae 12 weight portion, Semen coryli heterophyllae 13 weight portion, Stigma Maydis 12 weight portion, Folium Symplocoris Caudatae 13 weight portion, rock wind 13 weight portion and Radix Glycyrrhizae 25 weight portion.

5. the preparation method being used for the treatment of the medicine of pig lung plague as described in any one of claim 1-4, is characterized in that, described preparation method comprises the following steps:

The first step, according to ratio of weight and number weighting raw materials material, after mixing, be ground into powder;

Second step, the first step obtained powder and add in cold water and soak 24 hours ~ 36 hours, with slow fire boiling, decocting time is 2 hours ~ 3 hours, decoction liquor is filtered, obtain the first filtrate, the quality of the water added is 3 ~ 5 times of the powder quality that the first step obtains;

3rd step, second step is filtered the filtering residue obtained again add in cold water, with slow fire boiling 2 ~ 4 times, each to decoct 1 hour ~ 2 hours, filter and merge filtrate, obtaining the second filtrate, the quality of the water added and identical in second step;

4th step, the first filtrate and the second filtrate merged, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, dry cream is put into spray dryer dry, ensure that inlet temperature is at 170 DEG C ~ 190 DEG C, leaving air temp 60 DEG C ~ 80 DEG C, be ground into 200 order ~ 400 orders subsequently, obtain drug powder.