CN103656145A - Drug for curing swine plague and preparation method thereof - Google Patents
Drug for curing swine plague and preparation method thereof Download PDFInfo
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- CN103656145A CN103656145A CN201310715281.4A CN201310715281A CN103656145A CN 103656145 A CN103656145 A CN 103656145A CN 201310715281 A CN201310715281 A CN 201310715281A CN 103656145 A CN103656145 A CN 103656145A
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Abstract
The invention discloses drug for curing swine plague and a preparation method thereof. The drug comprises root of straight sophora, bovista, goldthread root, cape jasmine, scutellaria root, pollen, immature bitter orange, rhubarb, figwort root, Chinese gentian, akebia stem, forsythia fruit, balloonflower, compound of glauber-salt and liquorice, silkworm larva, cyathocline purpurea, semen lepidii, perilla fruit, Zhejiang fritillary bulb, radix et rhizoma thalictri, areca and aristolochia fruid. The drug has the benefits that the drug is based on clearing away heat and toxic material, ventilating the lung and resolving phlegm, also has the effects of throat expediting and relieving inflammation and alleviating pain and is used for curing swine plague, and compared with traditional Chinese medicine and Western medicine in the prior art, the drug has the advantages of obvious curative effect on curing pigs with swine plague, high cure rate, small side effect, uneasiness in relapse and low cost.
Description
Technical field
The present invention relates to herbal medicine technical field, particularly a kind of medicine that is used for the treatment of pig lung plague and preparation method thereof.
Background technology
Pig lung plague is by the caused a kind of acute infectious disease of multiple lethal pasteurellosis bacillus (swine pasteurellosis), is commonly called as " sore throat with dysphagia ", " swollen neck pestilence ".Acute or chronic process, the acute septicemia that is changes, bottleneck throat swelling, height dyspnea.Pasteurella multocida can infect many animals, and pig is wherein a kind of, and the pig at various ages all can infection morbidity.It is generally acknowledged that this bacterium is a kind of conditionality pathogen, when pig is in bad external environment, as cold, sultry, weather drastic change, humidity, crowded, improper ventilation, malnutrition, fatigue, long-distance transport etc., cause the resistance of pig to decline, at this moment pathogen breeds and causes morbidity in a large number.Sick pig, through discharges of bacteria such as secretions, Excretas, pollutes drinking-water, feedstuff, apparatus and external environment in addition, through digestive tract, is transmitted to health pig, is also the important route of infection.Also can discharge cause of disease by cough, sneeze, by the spittle through respiratory tract infection.In addition, hematophagus is bitten skin and mucosa wound all can infect.Primary disease is general without significantly seasonal, but colding and heat succeed each other, climate variability, high temperature season is multiple, is generally sporadic or endemicity.
To many animals and have per capita pathogenic, with the susceptible of pig, without obvious seasonal generation, but to cold and heat succeed each other, weather drastic change, humidity, the factors such as rainy generation is more, and malnutrition, long-distance transport, raising condition change, bad promote primary disease to occur, and often concentrate morbidity.
According to course of disease length and clinical manifestation, be divided into the most acute, acute and chronic type.Acute: there is not any symptom, sudden onset, dead rapidly.The course of disease slightly elder shows fervescence to 41～42 ℃, and appetite is useless absolutely, dyspnea, heart beating rapidly, visual mucosa cyanosis, there is purplish-red macula in skin.Bottleneck throat and cervical region heating, red and swollen, hard, severe patient is extended down to the basal part of the ear, front.Sick pig breathes and is the devil, and is often sitting position of dog gesture, extends head and neck, sometimes can send the sound of stridulating, and mouth and nose flow out white foam, sometimes with color.Once there is serious dyspnea, the state of an illness often worsens rapidly, very fast dead.Mortality rate Chang Gaoda 100%, spontaneous remission person is rare.Acute: this type is the most common.Fervescence to 40～41 ℃, the initial stage is spastic dry cough, dyspnea, mouth and nose flow out foam, are sometimes mixed with blood, after become cough caused by pathogenic damp.With disease, breathe more difficultly, often make sitting position of dog gesture, chest palpation has pain.Lassitude, inappetence or absolutely useless, there is erythema in skin, later stage languishment does not rise sleepingly, how because of death by suffocation.The course of disease 5～8 days, the dead does not transfer to chronic.Chronic type: main manifestations is pneumonia and chronic gastroenteritis.Time have persistence cough and dyspnea, have a little hydrodynamic or purulence nose liquid.Arthroncus, often has diarrhoea, inappetence, and malnutrition, has crust sample eczema, and growth stops, skeletonize, the course of disease is more than 2 weeks, and most generations are dead.
Be 1-5 days general incubation period.Acute, night is normal food also, and m seq is dead, often can't see reveal any symptoms, and the course of disease is slightly long, fervescence is to 41-42 ℃, and appetite is absolutely useless, and asthenia universalis does not rise sleepingly, dyspnea, be sitting position of dog gesture, mouth and nose flow out foam, course of disease 1-2 day, mortality rate 100%.Acute (pleuropneumonia type), body temperature 40-41 ℃, spastic dry cough, discharges sputum and is mucus or purulence, dyspnea, rear one-tenth is wet, pain is coughed, and chest pain is that dog sits, dog is sleeping, first constipation, rear diarrhoea, visible congestion ecchymosis on skin.Chronic type, continuing has cough, dyspnea, nose flows a small amount of mucus, sometimes occurs arthroncus, become thin, diarrhoea, dead through more than 2 weeks exhaustion, the most acute and acute pig of case fatality rate 60-70%. shows as septicemia and pleuropneumonia.Affected pig portion is red and swollen, dyspnea, mucosa and skin cyanosis, body temperature 41-42 ℃, course of disease 1-2 day.Chronic type is shown in persistent cough, dyspnea, and suppurating property nose liquid, becomes thin, exhaustion.Acute: whole body mucosa, serous coat and subcutaneous tissue have petechia, the hemorrhagic edema of larynx and surrounding tissue thereof of especially take is feature.Cut skin of neck, have the yellowish or grey cyan fiber disposition serosity of a large amount of glue peptone samples.Lymph nodes of body as a whole swelling, hemorrhage.On visceral pericardium and pericardium, there is petechia.Lung acute edema.Spleen has hemorrhage but not enlargement.Skin has ecchymosis.Bleeding of gastrointestinal mucosa inflammation.Acute: except having the pathological changes of acute, its distinctive pathological changes is fibrinous pneumonia.Main manifestations is in trachea, bronchus, to have volume foam mucus.Lung has Gan Bian district in various degree, with edema due to disorder of QI and edema.The long Fei Ganbian of the course of disease often has necrosis region in district, and between pulmonary lobule, serosity infiltrates, and lung tangent plane is marble sample outward appearance, and pleura has fiber disposition attachment, pleura and sick adhesion of lung.Thoracic cavity and pericardial effusion.Chronic type: corpse skeletonize, anemia.Lungs You Ganbian district, and have yellow or Lycoperdon polymorphum Vitt necrosis region, there is connective tissue outside, includes caseous substance; Some formation cavity, communicates with bronchus.Pericardium and hydrothorax, thoracic cavity has fiber disposition calm, and pleura is plump, usually with sick adhesion of lung.Sometimes at Intercostal muscle, bronchus peripheral lymph node, mediastinal lymph nodes and tonsil, joint and subcutaneous tissue, see there is necrosis region.Acute: except the hemorrhagic pathological changes of whole body mucosa, organa parenchymatosum, lymph node, distinctive pathological changes is fibrinous pneumonia, has Gan Bian district in various degree.Pleura and adhesion of lung, lung tangent plane is marble grain, thoracic cavity, pericardial effusion, trachea, bronchial mucosa inflammation have cystose mucus.Chronic type: Fei Ganbian district expands, has lark or Lycoperdon polymorphum Vitt downright bad, inside has caseous substance, and some formation cavity, highly becomes thin, anemia, and subcutaneous tissue is shown in necrosis region.
Morbus acutissimus example, because morbidity is anxious, often has little time treatment, sick pig dead.Penicillin, streptomycin and Cyclomycin family antibiotic have certain curative effect to pig lung plague.Antibiotic and sulphonamides share, as tetracycline+sulfadimidine, and tylosin+sulfadimidine.In treatment, be stressed that especially, this bacterium very easily develops immunity to drugs, and therefore with good conditionsily should do drug sensitive test, selects sensitive medicaments treatment.Prevention: the annual spring and autumn of (1) epidemic prevention regularly carries out immunity inoculation twice with pig lung plague aluminium hydroxide formaldehyde vaccine or the oral weak toadstool Seedling of pig lung plague.Also can select pig erysipelas, pig lung plague aluminium hydroxide bigeminy Seedling, swine fever, pig erysipelas, the weak malicious trigeminy vaccine of pig lung plague.Vaccination a few days ago with latter 7 days in, forbidding antibacterials.(2) improve feeding and management in the situation that of conditions permit, advocate early weaning.The production routine of the all-in and all-out system of employing; Enclosed swinery, reduces and draws from the outside pig; The measures such as density that reduce swinery may be helpful to controlling primary disease meeting.(3) chemoprophylaxis, to regular incidence pig farm, add antimicrobial drug and prevent in feedstuff.According to primary disease propagating characteristic, first anti-system answers the premunition of enhancing body.Strengthen feeding and management, elimination may reduce resistance against diseases factor and pathogenic inducement is as crowded in colony house, ventilation and lighting is poor, moist, catch cold etc.Colony house, environment are regularly sterilized.After new introduction pig quarantines one month, health can be gregarious.Carrying out prophylactic immunization, is the important measures of prevention primary disease, regularly carries out every year planned inoculation.The pig lung plague vaccine of producing at present has five kinds of pig lung plague inactivated vaccines, the weak toadstool Seedling of pig lung plague Inner Mongol system, pig lung plague eo-630 live vaccine, pig lung plague ta53 live vaccine, pig lung plague c20 live vaccine, use, preservation and points for attention by specification.While there is primary disease, should be by sick pig isolation, blockade, tightly sterilization.With the pig on hurdle, with serum or with vaccine, promptly prevent.To distributing disease pig, should isolate for treatment, sterilization pig house.To after newly buying pig and quarantining one month without the gregarious raising of ANOMALOUS VARIATIONS.Treatment can adopt following medicine:
1, penicillin 80-240 ten thousand intramuscular injection use 10-20 milliliters of 10% sulfadiazines to inject 5-10 milliliters of intramuscular injection of water simultaneously, and 12 hours once, is used in conjunction 3 days.
2,45 kilograms of above 2500 milligrams, chloromycetin, 3000 milligrams of streptomycins, 20 milliliters of intramuscular injection of 10% aminophenazone for pig, 6 hours 1 time, are used in conjunction 2 times.
3, gentamycin 1-2 mg/kg body weight, tetracycline 7-15 mg/kg body weight, every day 2 times, until temperature decline.
Western medicine easily develops immunity to drugs, and Chinese medicine has no side effect, without Drug resistance, its role is to, the QI and blood of conditioning human body, smooth the liver and regulate the spleen, metabolic function and the immunologic function of adjustment body, there is again antivirus action, therefore body recovery is fast, do not recur after more, with herbal control pig lung plague, be the problem of the concentrated research of many veterinary work persons in recent years.The Chinese medicine of developing at present be not as good as Western medicine, therefore has report that Western medicine and Chinese medicine composition are used to the treatment curative effect of pig lung plague, though it has advantages of relative low price, effective speed is slower, when medicine time is longer, just can make transference cure.
Summary of the invention
Technical problem to be solved by this invention is to be to provide a kind of medicine that is used for the treatment of pig lung plague, has overcome the various defects of prior art Chinese medicine and western medicine and Chinese medicine, to suffering from the treatment of pig lung plague, has evident in efficacy, treating both the principal and secondary aspects of a disease, cure rate is high, and side effect is little, the advantage that cost is low.
In order to realize foregoing invention object, the invention provides a kind of medicine that is used for the treatment of pig lung plague, described medicine comprises Radix Sophorae Tonkinensis, Lasiosphaera Seu Calvatia, Rhizoma Coptidis, Fructus Gardeniae, Radix Scutellariae, pollen, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, Radix Scrophulariae, Radix Gentianae, Caulis Akebiae, Fructus Forsythiae, Radix Platycodonis, Matrii Sulfas Exsiccatus, Bombyx Batryticatus, cup chrysanthemum, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Bulbus Fritillariae Thunbergii, Radix et Rhizoma Thalictri, Semen Arecae and Fructus Aristolochiae.
Described medicine is comprised of the crude drug of following parts by weight: Radix Sophorae Tonkinensis 11～20 weight portions, Lasiosphaera Seu Calvatia 11～25 weight portions, Rhizoma Coptidis 11～45 weight portions, Fructus Gardeniae 10～16 weight portions, Radix Scutellariae 10～16 weight portions, pollen 10～15 weight portions, Fructus Aurantii Immaturus 10～15 weight portions, Radix Et Rhizoma Rhei 10～16 weight portions, Radix Scrophulariae 10～20 weight portions, Radix Gentianae 10～15 weight portions, Caulis Akebiae 10～15 weight portions, Fructus Forsythiae 10～20 weight portions, Radix Platycodonis 10～15 weight portions, Matrii Sulfas Exsiccatus 10～15 weight portions, Bombyx Batryticatus 10～15 weight portions, cup chrysanthemum 10～15 weight portions, Semen Lepidii (Semen Descurainiae) 10～15 weight portions, Fructus Perillae 10～20 weight portions, Bulbus Fritillariae Thunbergii 10～15 weight portions, Radix et Rhizoma Thalictri 10～15 weight portions, Semen Arecae 10～15 weight portions and Fructus Aristolochiae 10～15 weight portions.
Described medicine is preferably comprised of the crude drug of following parts by weight: Radix Sophorae Tonkinensis 15 weight portions, Lasiosphaera Seu Calvatia 18 weight portions, Rhizoma Coptidis 29 weight portions, Fructus Gardeniae 13 weight portions, Radix Scutellariae 13 weight portions, pollen 12 weight portions, Fructus Aurantii Immaturus 12 weight portions, Radix Et Rhizoma Rhei 13 weight portions, Radix Scrophulariae 15 weight portions, Radix Gentianae 12 weight portions, Caulis Akebiae 13 weight portions, Fructus Forsythiae 15 weight portions, Radix Platycodonis 13 weight portions, Matrii Sulfas Exsiccatus 13 weight portions, Bombyx Batryticatus 12 weight portions, cup chrysanthemum 12 weight portions, Semen Lepidii (Semen Descurainiae) 13 weight portions, Fructus Perillae 15 weight portions, Bulbus Fritillariae Thunbergii 13 weight portions, Radix et Rhizoma Thalictri 12 weight portions, Semen Arecae 12 weight portions and Fructus Aristolochiae 13 weight portions.
Described medicine also comprises Semen coryli heterophyllae, Stigma Maydis, Folium Symplocoris Caudatae, rock wind and Radix Glycyrrhizae.
Described medicine is comprised of the crude drug of following ratio of weight and number: Radix Sophorae Tonkinensis 15～20 weight portions, Lasiosphaera Seu Calvatia 12～25 weight portions, Rhizoma Coptidis 20～35 weight portions, Fructus Gardeniae 10～16 weight portions, Radix Scutellariae 10～16 weight portions, pollen 10～15 weight portions, Fructus Aurantii Immaturus 10～15 weight portions, Radix Et Rhizoma Rhei 10～16 weight portions, Radix Scrophulariae 11～15 weight portions, Radix Gentianae 11～15 weight portions, Caulis Akebiae 11～15 weight portions, Fructus Forsythiae 11～15 weight portions, Radix Platycodonis 11～15 weight portions, Matrii Sulfas Exsiccatus 10～15 weight portions, Bombyx Batryticatus 10～15 weight portions, cup chrysanthemum 11～15 weight portions, Semen Lepidii (Semen Descurainiae) 10～15 weight portions, Fructus Perillae 11～18 weight portions, Bulbus Fritillariae Thunbergii 11～15 weight portions, Radix et Rhizoma Thalictri 11～15 weight portions, Semen Arecae 11～15 weight portions, Fructus Aristolochiae 11～14 weight portions, Semen coryli heterophyllae 11～14 weight portions, Stigma Maydis 10～15 weight portions, Folium Symplocoris Caudatae 11～14 weight portions, rock wind 10～15 weight portions and Radix Glycyrrhizae 15～35 weight portions.
Described medicine is preferably comprised of the crude drug of following ratio of weight and number: Radix Sophorae Tonkinensis 18 weight portions, Lasiosphaera Seu Calvatia 19 weight portions, Rhizoma Coptidis 32 weight portions, Fructus Gardeniae 13 weight portions, Radix Scutellariae 13 weight portions, pollen 12 weight portions, Fructus Aurantii Immaturus 12 weight portions, Radix Et Rhizoma Rhei 13 weight portions, Radix Scrophulariae 13 weight portions, Radix Gentianae 13 weight portions, Caulis Akebiae 12 weight portions, Fructus Forsythiae 13 weight portions, Radix Platycodonis 13 weight portions, Matrii Sulfas Exsiccatus 12 weight portions, Bombyx Batryticatus 12 weight portions, cup chrysanthemum 13 weight portions, Semen Lepidii (Semen Descurainiae) 13 weight portions, Fructus Perillae 15 weight portions, Bulbus Fritillariae Thunbergii 13 weight portions, Radix et Rhizoma Thalictri 13 weight portions, Semen Arecae 13 weight portions, Fructus Aristolochiae 12 weight portions, Semen coryli heterophyllae 13 weight portions, Stigma Maydis 12 weight portions, Folium Symplocoris Caudatae 13 weight portions, rock wind 13 weight portions and Radix Glycyrrhizae 25 weight portions.
In order better to realize foregoing invention object, the invention provides a kind of preparation method that is used for the treatment of the medicine of pig lung plague, it is characterized in that, described preparation method comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials material, after mixing, be ground into powder;
Second step, the first step is obtained to powder add in cold water and soak 24 hours～36 hours, with slow fire boiling, decocting time is 2 hours～3 hours, and decoction liquor is filtered, obtain the first filtrate, the quality of the water adding is 3～5 times of the powder quality that obtains of the first step;
The 3rd step, the filtering residue that second step filter is obtained add in cold water again, with slow fire boiling 2～4 times, decoct 1 hour～2 hours at every turn, filter and merge filtrate, obtain the second filtrate, identical in the quality of the water adding and second step;
The 4th step, the first filtrate and the second filtrate are merged, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, dry cream is put into spray dryer dry, guarantee that inlet temperature is at 170 ℃～190 ℃, 60 ℃～80 ℃ of leaving air temps, be ground into subsequently 200 order～400 orders, obtain drug powder.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: the present invention be take heat-clearing and toxic substances removing, dispersing lung-QI and dissipating phlegm as main, take tonneau throat, anti-inflammatory analgetic is the auxiliary medicine that treatment pig lung plague is provided, compare with Western medicine with Chinese medicine of the prior art, to suffer from the treatment of the pig of pig lung plague have advantages of evident in efficacy, cure rate is high, side effect is little, be difficult for recurrence, cost is low.
The specific embodiment
According to clinical manifestation and course of disease process, can be divided into the most acute, acute and chronic three types.The most acute: there is not any symptom, sudden onset, dead rapidly.The course of disease slightly elder shows fervescence to 41～42 ℃, and appetite is useless absolutely, dyspnea, heart beating rapidly, visual mucosa cyanosis, there is purplish-red macula in skin.Bottleneck throat and cervical region heating, red and swollen, hard, severe patient is extended down to the basal part of the ear, front.Sick pig breathes and is the devil, and is often sitting position of dog gesture, extends head and neck, sometimes can send the sound of stridulating, and mouth and nose flow out white foam, sometimes with color.Once there is serious dyspnea, the state of an illness often worsens rapidly, very fast dead.Mortality rate Chang Gaoda 100%, spontaneous remission person is rare.Acute: this type is the most common.Fervescence to 40～41 ℃, the initial stage is spastic dry cough, dyspnea, mouth and nose flow out foam, are sometimes mixed with blood, after become cough caused by pathogenic damp.With disease, breathe more difficultly, often make sitting position of dog gesture, chest palpation has pain.Lassitude, inappetence or absolutely useless, there is erythema in skin, later stage languishment does not rise sleepingly, how because of death by suffocation.The course of disease 5～8 days, the dead does not transfer to chronic.Chronic type: main manifestations is pneumonia and chronic gastroenteritis.Time have persistence cough and dyspnea, have a little hydrodynamic or purulence nose liquid.Arthroncus, often has diarrhoea, inappetence, and malnutrition, has crust sample eczema, and growth stops, skeletonize, the course of disease is more than 2 weeks, and most generations are dead.Chinese veterinarian thinks, pig lung plague is many catches a cold because feeding and management is bad and weather fusion is suffered from cold or suffers from other diseases, body healthy energy is impaired, defend outer ability and reduce, pathogenic factor is invaded lung through mouth and nose and is defended, and heat is evaporated poison so that qi depression to blood stasis, then pathogenic heat upper punch throat, so that pharyngitis burning pain, phlegm-fire is strongly fragrant in lung meridian, impairment of dispersing and descending function of the lung and cause QI rising in reverse order cough with asthma, dyspnea; Heat enters nutrient blood, sees skin erythema etc.Treatment pig lung plague disease should be take heat-clearing and toxic substances removing, dispersing lung-QI and dissipating phlegm as main, take tonneau throat, anti-inflammatory analgetic as auxiliary.
According to above-mentioned theory and principle, the invention provides a kind of medicine that is used for the treatment of pig lung plague, comprise Radix Sophorae Tonkinensis, Lasiosphaera Seu Calvatia, Rhizoma Coptidis, Fructus Gardeniae, Radix Scutellariae, pollen, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, Radix Scrophulariae, Radix Gentianae, Caulis Akebiae, Fructus Forsythiae, Radix Platycodonis, Matrii Sulfas Exsiccatus, Bombyx Batryticatus, cup chrysanthemum, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Bulbus Fritillariae Thunbergii, Radix et Rhizoma Thalictri, Semen Arecae and Fructus Aristolochiae.
The pharmacological property of each raw material is as follows:
Radix Sophorae Tonkinensis: hardship, cold; Poisonous.Attach to the lung and stomach meridians.Function cures mainly: heat-clearing and toxic substances removing, detumescence sore-throat relieving.For fire-toxin, pent up laryngopharynx swelling and pain, gingivitis.
Lasiosphaera Seu Calvatia: pungent, flat.Function cures mainly: heat clearing away, sore-throat relieving, hemostasis.Cure mainly: pharyngolaryngitis, tonsillitis; Traumatic hemorrhage is controlled in external, bleeding hemorrhoids chilblain.
Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.For cold and heat, tie mutually damp and hot middle resistance, feeling of fullness vomiting.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.The diseases such as, vomiting damp and hot for retention of damp-heat in the interior, the intestines and stomach, dysentery.Join Radix Scutellariae, Radix Et Rhizoma Rhei etc., can control the card of retention of damp-heat in the interior.To the damp and hot the intestines and stomach of being reluctant to leave, often coordinate the Rhizoma Pinelliae, Caulis Bambusae In Taenia; Join the Radix Aucklandiae, Radix Scutellariae, Radix Puerariae etc. to control dysentery.
Fructus Gardeniae: bitter in the mouth, cold in nature, enter the heart, lung, three warmers, have the effect of relieving restlessness pathogenic fire purging, dispersing the stagnated live-QI to relieve the stagnation of QI, clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, be mainly used in epidemic febrile disease heat stagnation breast gastral cavity vexed uneasiness, bother not peaceful; Stagnation of liver-QI is not relaxed or Liver Channel has having a dizzy spell of heat, pain in chest and hypochondrium, conjunctival congestion dry pharynx; Jaundice due to damp-heat; The symptoms such as the abdominal distention of qi depression to blood stasis, the heat conduction of Fructus Gardeniae tonneau three warmers is descending, and has anti-hepatic injury effect.
Radix Scutellariae: have heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are used in fungal culture miscellaneous bacteria and infect special severity by the strong feature of broad-spectrum antibacterial action, fine by Radix Scutellariae extracting solution effect.< < Bencao Jingshu > >: Radix Scutellariae, its property is respectful clearly, so evil removing: so bitter in the mouth dampness; So YIN-cold victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, the disease of all damp and hot victory also, is analysed it, all diseases are from recover.Bitter cold can be except damp and hot, thus small intestinal profit and water from by, source is clearly flowed also clean.The blood person of closing, excess-heat is at blood system, and amenorrhea is made us obstructed in instant heating human blood chamber, damp and hot solution, Ying Qi is clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood is stayed knot, and is that carbuncle stain is also rotten: acute scleritis person, fire of moxibustion blood trouble also, removing heat from blood heat extraction, spontaneous recovery also.
Pollen: sweet, micro-hardship, is slightly cold.Attach to the lung and stomach meridians.Clearing away heat and promoting production of body fluid, detumescence and apocenosis.For calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.< < detailed outline > >: radices trichosanthis, sweet and slightly bitter taste acid, acid can be promoted the production of body fluid, therefore the profit of quenching the thirst is withered, micro-bitter pathogenic fire reducing, does not sweetly injure one's stomach, former times people only says its bitter cold, like deeply not examining.< < book on Chinese herbal medicine converges says > >: Radix Trichosanthis, move back the five internal organs hot and suffocating, as heart-fire, contain and dry tongue and mouth, lung-fire is contained and pharyngeal swelling sore throat, spleen-fire is contained and dispute tooth is swollen, and phlegm-fire is contained and cough is not peaceful.If the side of body of liver-fire is swollen migratory arthralgia caused by wind, the hectic fever due to YIN-deficiency dysphoria with smothery sensation of kidney fire, or carbuncle bursts and do not burst, and pyretic toxicity is loose, or five types of jaundice yellow skin and eye, and if if little water drenches puckeryly, be due to all burning hot pent-up, only phlegm-fire, falls in this agent energy relieving stagnation, and can control it.Its property is sweet cold again, kindly can control yearningly, controls empty yearningly from tonic, controls fire thirsty from the medicine of a cold nature, controls strongly fragrant yearningly from gas medicine, from blood medicine, controls excessive thirst, is to control thirsty key medicine also.
Fructus Aurantii Immaturus: bitter, pungent, sour, temperature.Return spleen, stomach warp.Function cures mainly: dispelling the stagnated QI removing food stagnancy, the loose painful abdominal mass of reducing phlegm.In stagnant, stop, feeling of fullness distending pain, heavy after dysentery, constipation, the stagnant vapour lock thoracic obstruction of expectorant, blocked-up chest; Gastroptosis, proctoptosis, uterine prolapse.
Radix Et Rhizoma Rhei: cure mainly excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; Scald.
Radix Scrophulariae: sweet in the mouth, hardship, salty; Cold nature.Return lung, stomach, kidney channel.Clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing.Pathogenic warmth is joined the army, the pericardium that caves in, and maculae caused by violent heat pathogen, constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus are hindered in consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin.There is clearing away heat and cooling blood, removing toxic substances, eliminating stagnation sore-throat relieving, the effect of YIN nourishing.Be used for: the warm febrile disease blood of joining the army, the card of consumption of YIN caused by febrile disease.There is clearing away heat and cooling blood, the effect of removing toxic substances YIN nourishing.
Radix Gentianae: hardship, cold.Return liver, gallbladder meridian.Function cures mainly: heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.For jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, conjunctival congestion, deafness, hypochondriac pain, bitter taste, convulsion with spasms.
Caulis Akebiae: bitter, be slightly cold.Enter heart channel, small intestine meridian, urinary bladder channel.There is clearing away heart-fire, diuresis, the effect of the stimulating milk secretion of stimulating the menstrual flow.For irritable feverish sensation in the chest, sore throat pharyngalgia, dark coloured urine, five types of stranguria, edema, whole body spasm and pain, amenorrhea breast is few.The puckery pain of pyretic stranguria, edema.This product energy inducing diuresis to remove edema, diarrhea is damp and hot, makes that damp and hot heresy is descending discharges from urine.Treatment damp-heat in the urinary bladder, oliguria with reddish urine, drenches the puckery pain of drop, the adapteds such as normal and Semen Plantaginis, Talcum; For edema, be equipped with Polyporus, Cortex Mori is equal to use.Aphtha of the mouth and tongue, vexed dark coloured urine.The fire of this product energy supernatant heart channel, under let out small intestinal heat.Often control flaming up of heart-fire, aphtha of the mouth and tongue, or intestinal and the diseases such as vexed dark coloured urine that cause under heart-fire moving downward, the adapteds such as many and Radix Rehmanniae, Radix Glycyrrhizae, Folium Bambusae.Amenorrhea breast is few.These product stimulating milk secretion of stimulating the menstrual flow.With controlling blood stasis amenorrhea, join Flos Carthami, Semen Persicae, Radix Salviae Miltiorrhizae and be equal to use; If deficient or obstructed with controlling milk, can be equal to use with Semen Vaccariae, Squama Manis; These product can also sharp blood vessels, get round by bribery, and join Ramulus Mori, Semen Coicis is equal to use, treats damp and hot arthralgia pain.
Fructus Forsythiae: bitter in the mouth, cold nature, enters the heart, liver, gallbladder, small intestine meridian, have heat-clearing and toxic substances removing, the effect of dispersing swelling and dissipating binds, for carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease is from the beginning of, warm joining the army, high hot excessive thirst, coma is sent out speckle, and the treatment of the card such as pyretic stranguria urine retention, has very strong inhibitory action to dysentery bacterium, staphylococcus aureus.
Radix Platycodonis: bitter in the mouth; Pungent; Property is put down.Return lung meridian.Effect: lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, fill blood, mend five kinds of over strain, foster the spirit of nobility.Cure mainly: cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.Energy expelling phlegm for arresting cough, and have lung qi dispersing, evacuation of pus effect.The direct stimulation of contained platycodin to oral cavity, throat, gastric mucosa, makes sputum dilution thereby reflexive ground increases bronchial mucosa hypersecretion, is easy to discharge; Radix Platycodonis has antitussive effect, has the antiinflammatory of enhancing and immunization, and its antiinflammatory intensity is similar to aspirin; Water extract can strengthen the phagocytic function of macrophage, strengthens the sterilizing power of neutrophilic leukocyte, improves lysozyme activity; Stress ulcer is had to preventive effect.The thick saponin of Radix Platycodonis has calmness, analgesia, refrigeration function, again can blood sugar lowering, cholesterol reducing, and relaxing smooth muscle.Platycodin has very strong haemolysis, but destroy and lose haemolysis oral can decomposition in digestive tract.
Matrii Sulfas Exsiccatus: salty, bitter, cold.Return stomach, large intestine channel.Function cures mainly: purging heat to relax the bowels, moistening for dryness and softening hard mass, the detumescence of relieving inflammation or internal heat.For excess-heat constipation, constipation due to dry stool, stagnant stomachache; External treatment laryngopharynx swelling and pain, aphtha of the mouth and tongue, gingival swelling and pain, conjunctival congestion, carbuncle, erysipelas.
Bombyx Batryticatus: acrid in the mouth; Salty; Property is put down.Return liver; Lung; Stomach warp.Function cures mainly: expelling wind and relieving convulsion; Dissipating phlegm and resolving masses; Resolving toxin and disinhibiting the throat.Main epilepsy seizures; the outlet oblique of eyes; prejudiced headache; sore throat; scrofula; mumps; rubella; sore.1. anticonvulsant action: 10% decocting liquid 2g/kg is oral to mice, and the convulsions that strychnine nitrate is caused has obvious antagonism.The mixture (i.e. the decoct of five brave Chinese medicine Zhuifengsans) being comprised of commercially available Bombyx Batryticatus, Periostracum Cicadae etc. can reduce strychnine, pentetrazole, cocaine, and nicotine etc. cause the death toll of mice convulsion.Artificial Bombyx Batryticatus decoct also has the effect of the mice convulsion due to antagonism strychnine.2. syngignoscism: alcohol water-leach liquor has syngignoscism to mice and rabbit, the oral 0.5g/20g of mice, subcutaneous injection 0.25g/20g, approximates the hypodermic hypnosis effect of 50mg/kg phenobarbital.3. the pharmacological action of Bombyx Batryticatus: the convulsions that Bombyx Batryticatus antagonism white mice is caused by strychnine nitrate, effect is that significantly result is consistent with Bombyx Batryticatus.Aspect reduction mortality rate, test group and matched group difference are not obvious, but Bombyx Batryticatus is consistent with the result of Bombyx Batryticatus.In two results, Bombyx Batryticatus is all slightly better than Bombyx Batryticatus.In addition, Bombyx Batryticatus still can suppress white mice S-180 (need further affirm), though staphylococcus aureus, escherichia coli, bacillus pyocyaneus etc. are had to inhibitory action, DeGrain.Due to, Bombyx Batryticatus convenient sources, therefore can be in order to replace Bombyx Batryticatus.4. the pharmacological research of Bombycis mori: the toxicity of Bombycis mori is very low.Teenage male mice body weight gain is had to facilitation, can obviously increase prostate one Seminal vesicle of castration mouse and castrated rats, the weight of preputial glands, show to there is androgen-like action.
Cup chrysanthemum: heat-clearing and toxic substances removing, anti-inflammation hemostasia, dehumidifying diuresis, parasite killing.Cure mainly acute gastroenteritis, heatstroke, cystitis, urethritis, pharyngolaryngitis, stomatitis, spits blood, epistaxis.
Semen Lepidii (Semen Descurainiae): pungent, bitter, Great Cold.Return lung, urinary bladder channel.Function cures mainly: eliminating pathogen from the lung for relieving asthma, line water detumescence.For sputum, stop up lung, dyspnea and cough with excessive sputum, fullness and distention in the chest and hypochondrium, must not put down sleepingly, and ascites pleural fluid is swollen, dysuria; Pulmonary heart disease edema.
Fructus Perillae: pungent, temperature.Return lung, large intestine channel.Function cures mainly: sending down the abnormal ascending QI expectorant, relieving cough and asthma, loosening bowel to relieve constipation.For expectorant, stop up QI rising in reverse order, cough and asthma, dryness of the intestine constipation.Pharmacological action: 1, the effect to blood fat, with the feedstuff containing perilla oil, feed chicken, can make chicken plasma cholesterol levels reduce, but mice is acted on without this, and cause the depilation of mice cervical region and skin lesion; With the feedstuff containing perilla oil, feed rabbit, can increase its body weight and liver weight, but the cholesterol level of blood plasma and liver is had no significant effect.2, bacteriostasis: experiment shows: perilla oil (0.1%) all has inhibitory action to the mycete of Bacillus proteus, Aspergillus niger, penicillium and occurring in nature. wherein to the nipalgin of the obviously strong what 0.05% of the effect of yeast and mold and 0.3% benzoic acid.3, anticorrosion, antioxidation: the ethanol extraction of Fructus Perillae after defat has anticorrosion and antioxidation.The long-term storage of available what food and medicine. its antioxidation is strong compared with 0.02% BHT (2,6-di-t-butyl p-Hydroxybenzylalcohol).
Bulbus Fritillariae Thunbergii: hardship, cold.Return lung, heart channel.Function cures mainly: heat clearing away eliminating stagnation, and preventing phlegm from forming and stopping coughing, for wind-heat invading the lung, phlegm-fire cough, lung abscess, acute mastitis, scrofula, sore.
Radix et Rhizoma Thalictri: hardship, cold.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.For enteritis, dysentery, jaundice, conjunctival congestion and swelling pain.
Semen Arecae: bitter in the mouth; Pungent; Warm in nature.Return stomach; Large intestine channel.Effect, anthelmintic; Removing food stagnancy; The therapeutic method to keep the adverse QI flowing downwards; Row water; Preventing the attack (or recurrence) of malaria.Malnutrition due to parasitic infestation; Dyspepsia; Abdominal distention; Heavy after dysentery; Foot gas; Edema; Malaria.Resisting pathogenic microbes effect Semen Arecae infusion (1:1) in vitro to trichophyton, permitted the dermatophytess such as blue achorion and had inhibitory action in various degree.Decoct and some strain of water logging agent infected by influenza A type have certain inhibitory action, and antiviral effect may be relevant with wherein contained tannin.
Fructus Aristolochiae: have the disappear effect of hemorrhoid of lung heat clearing sending down the abnormal ascending QI, relieving cough and asthma, bowel relieving, its stem claims Herba Aristolochiae to have to regulate the flow of vital energy, the effect of damp eliminating, promoting blood circulation and stopping pain, and its root claims Radix Aristolochiae to have the effect of promoting the circulation of QI to relieve pain, removing toxic substances and promoting subsidence of swelling.
Medicine of the present invention preferably also comprises: Semen coryli heterophyllae, Stigma Maydis, Folium Symplocoris Caudatae, rock wind and Radix Glycyrrhizae.
Semen coryli heterophyllae: sweet, flat.1. < < Kaibao Bencao > >: " sweet in the mouth is flat, nontoxic." 2. > > is wanted in the bun of < < medical center: " is sweet salty, flat." function cures mainly: in tune, and appetizing, improving eyesight.1. Cui Yu stannum < < cuisine canon > >: " three worms are gone in the improving eyesight of food." 2. < < Japan hanako materia medica > >: " fertile white man, only hungry, in tune, appetizing." 3. < < Kaibao Bencao > >:, " main physical strength profiting, wide the intestines and stomach make us not hungry, hike."
Stigma Maydis: sweet, light, flat.Return bladder, liver, gallbladder meridian.Function cures mainly: inducing diuresis to remove edema, suppressing the hyperactive liver function of gallbladder promoting.For acute and chronic nephritis, edema, acute hepatitis, chronic hepatitis, hypertension, diabetes, chronic sinusitis, lithangiuria, Biliary Calculi, the diseases such as dysuria, damp and hot jaundice.And can prevent habitual abortion.
Folium Symplocoris Caudatae: pungent, micro-hardship, cool.Function cures mainly: heat-clearing and toxic substances removing, eliminating stasis to stop pain.For cold, fever, toothache, menoxenia, infantile eczema; Furuncle toxic swelling, traumatic injury are controlled in external.
Rock wind: hardship; Cool.Function cures mainly: relieving stranguria by diuresis; Heat-clearing and toxic substances removing.Main stranguria; Edema; Acute mastitis; Sore
Radix Glycyrrhizae: property is flat, and sweet in the mouth, returns 12 warps.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strongly have removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic be so that the pharmacological action such as anticancer, Radix Glycyrrhizae has blood fat reducing, antioxidative effect.
Embodiment 1 medicine 1
The embodiment of the present invention provides a kind of medicine that is used for the treatment of pig lung plague, medicine is comprised of the raw material of following parts by weight: Radix Sophorae Tonkinensis 15 weight portions, Lasiosphaera Seu Calvatia 18 weight portions, Rhizoma Coptidis 29 weight portions, Fructus Gardeniae 13 weight portions, Radix Scutellariae 13 weight portions, pollen 12 weight portions, Fructus Aurantii Immaturus 12 weight portions, Radix Et Rhizoma Rhei 13 weight portions, Radix Scrophulariae 15 weight portions, Radix Gentianae 12 weight portions, Caulis Akebiae 13 weight portions, Fructus Forsythiae 15 weight portions, Radix Platycodonis 13 weight portions, Matrii Sulfas Exsiccatus 13 weight portions, Bombyx Batryticatus 12 weight portions, cup chrysanthemum 12 weight portions, Semen Lepidii (Semen Descurainiae) 13 weight portions, Fructus Perillae 15 weight portions, Bulbus Fritillariae Thunbergii 13 weight portions, Radix et Rhizoma Thalictri 12 weight portions, Semen Arecae 12 weight portions and Fructus Aristolochiae 13 weight portions.
The preparation method of medicine comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials material, after mixing, be ground into powder;
Second step, the first step is obtained to powder add in cold water and soak 36 hours, with slow fire boiling, decocting time is 2.5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 4 times of the powder quality that obtains of the first step;
The 3rd step, the filtering residue that second step filter is obtained add in cold water again, with slow fire boiling 3 times, decoct 1 hour at every turn, filter and merge filtrate, obtain the second filtrate, identical in the quality of the water adding and second step;
The 4th step, the first filtrate and the second filtrate are merged, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, guarantees that inlet temperature is at 180 ℃, and 70 ℃ of leaving air temps, are ground into 300 orders subsequently, obtain drug powder.
Embodiment 2 medicines 2
The embodiment of the present invention 2 provides a kind of medicine that is used for the treatment of pig lung plague, medicine comprises the raw material of following parts by weight: Radix Sophorae Tonkinensis 18 weight portions, Lasiosphaera Seu Calvatia 19 weight portions, Rhizoma Coptidis 32 weight portions, Fructus Gardeniae 13 weight portions, Radix Scutellariae 13 weight portions, pollen 12 weight portions, Fructus Aurantii Immaturus 12 weight portions, Radix Et Rhizoma Rhei 13 weight portions, Radix Scrophulariae 13 weight portions, Radix Gentianae 13 weight portions, Caulis Akebiae 12 weight portions, Fructus Forsythiae 13 weight portions, Radix Platycodonis 13 weight portions, Matrii Sulfas Exsiccatus 12 weight portions, Bombyx Batryticatus 12 weight portions, cup chrysanthemum 13 weight portions, Semen Lepidii (Semen Descurainiae) 13 weight portions, Fructus Perillae 15 weight portions, Bulbus Fritillariae Thunbergii 13 weight portions, Radix et Rhizoma Thalictri 13 weight portions, Semen Arecae 13 weight portions, Fructus Aristolochiae 12 weight portions, Semen coryli heterophyllae 13 weight portions, Stigma Maydis 12 weight portions, Folium Symplocoris Caudatae 13 weight portions, rock wind 13 weight portions and Radix Glycyrrhizae 25 weight portions.
The preparation method of medicine comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials material, after mixing, be ground into powder;
Second step, the first step is obtained to powder add in cold water and soak 30 hours, with slow fire boiling, decocting time is 3 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 5 times of the powder quality that obtains of the first step;
The 3rd step, the filtering residue that second step filter is obtained add in cold water again, with slow fire boiling 2 times, decoct 2 hours at every turn, filter and merge filtrate, obtain the second filtrate, identical in the quality of the water adding and second step;
The 4th step, the first filtrate and the second filtrate are merged, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, guarantees that inlet temperature is at 190 ℃, and 80 ℃ of leaving air temps, are ground into 400 orders subsequently, obtain drug powder.
Acute toxicity test
40 of application NIH mices, SPF level, male and female half and half, body weight 18～22g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, matched group and administration group, test front fasting 12 hours; Medicine dissolution prepared by embodiments of the invention 1 is in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 32.9 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, after administration, Continuous Observation is 14 days, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage tablet LD50>32.9 of the present invention crude drug/kg, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention is 4.4g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.073g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight take 20g) oral administration gavage Chinese medicine of the present invention is quantity 901 times.Therefore the acute toxicity of the embodiment of the present invention 1 medicine is low, clinical drug safety.Take the medicine test method identical as object adopts of the embodiment of the present invention 2, result proves that the acute toxicity of embodiment 2 medicines is low equally, clinical drug safety.
Long term toxicity test
The embodiment of the present invention 1 medicine to mice by 10.78,20.35 and 16 weeks (1.0ml/100g body weight of 33.48g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: the medicine of the embodiment of the present invention 1 all has no significant effect indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.The medicine that the embodiment of the present invention 1 is described to mice long-term prescription after toxicity little, after drug withdrawal, there is no difference reaction, application safety yet.Take the medicine test method identical as object adopts of the embodiment of the present invention 2, the medicine that result proves embodiment 2 equally to mice long-term prescription after toxicity little, after drug withdrawal, there is no difference reaction, application safety yet.
Clinical trial
1.1 for examination material
1.1.1 for examination animal
On pig farm, Qingdao, Shandong Province, choose at random 225 healthy growing and fattening pigs, as experiment pig.
1.1.2 for prelibation strain
Pig pasteurellosis bacillus C44-41 and standard thereof are anti-clear, by China Veterinary Drugs Supervisory Inst., are provided, and before infecting, with broth bouillon, cultivate voluntarily.
1.1.3 medicine
The medicine 1 of embodiment 1 preparation, sneaks in feedstuff according to the 5-10% of feedstuff gross weight; The medicine 2 of embodiment 2 preparations, sneaks in feedstuff according to the 5-10% of feedstuff gross weight; Penicillin 80-240 ten thousand+10% sulfadiazine injection.
1.2 test method
1.2.1 inoculation test
Cultured pig pasteurellosis bacillus C44-41 meat soup is injected after ear respectively, and infective dose is 12.6 bacterium/kg.w.Infect in latter five days and have 220 pigs to occur pig lung plague symptom, select 180 ill pigs as experiment pig.
1.2.2 experiment grouping
180 ill piglets are divided into three groups at random, 60 every group, i.e. embodiment group 1, embodiment group 2 and matched group.
1.2.3 test method
The pig that occurs pig lung plague after infection adopts respectively different Therapeutic Method, and wherein, embodiment group 1 is used the embodiment of the present invention 1 Drug therapy, medicine is sneaked in feedstuff, according to conventional method, feed, each mixed volume is the 5-10% of feedstuff gross weight, uses continuously three days; Embodiment group 2 is used the embodiment of the present invention 2 Drug therapys, and medicine is sneaked in feedstuff, according to conventional method, feeds, and each mixed volume is the 5-10% of feedstuff gross weight, uses continuously three days; Matched group is used penicillin 80-240 ten thousand intramuscular injection, injects the intramuscular injection of water 5-10 milliliter with 10% sulfadiazine 10-20 milliliter simultaneously, and 12 hours once, is used in conjunction 3 days.
1.2.4 observed and recorded
After counteracting toxic substances, observe clinical symptoms and the pathological change of respectively organizing ill pig, and compare its order of severity, the therapeutic effect after the rear death toll of record infection, treatment in three days finish.
2 results
2.1 criterion of therapeutical effect
Cure: ill temperature of pig body, body colour, breathing, appetite are all recovered normally, cough, diarrhoea, edema phenomenon disappear;
Effective: ill temperature of pig body, body colour, breathing, appetite are progressively recovered normally, and cough, diarrhoea, edema alleviate;
Invalid: ill pig symptom is not alleviated, and even increases the weight of death.
2.2 observed results are as shown in table 1.
Data from table 1: compare with matched group, the medicine of the embodiment of the present invention 1 and embodiment 2 has evident in efficacy to the treatment of pig lung plague, and side effect is low, the advantage that treated effect is high; In long-term observation subsequently, find, the pig that embodiment group 1 and embodiment group 2 cured again sickness rate is starkly lower than the pig of matched group.
After 2.3 counteracting toxic substances symptom with cut open inspection result
After counteracting toxic substances, the symptom of ill pig is: more than fervescence to 41 ℃, and inappetence or absolutely useless, dyspnea, there is purplish-red macula in skin.To infecting rear dead sick pig, dissect, find that whole body mucosa, serous coat and subcutaneous tissue have petechia, larynx and surrounding tissue hemorrhagic edema thereof, swollen lymph node, the intestines and stomach mucosa hemorrhage inflammation, indivedual pig lungs You Ganbian district, and have yellow or Lycoperdon polymorphum Vitt necrosis region.
Concrete case
Case 1
Certain raiser raises 121 of growing and fattening pigs altogether, and November in 2012,1 growing and fattening pigs sudden onset was dead, and other pigs all have pig lung plague symptom in various degree, expiratory dyspnea, and cervical region edema, there is purple erythema in skin.Dead pig is dissected to the dead Corii Sus domestica of discovery undertissue petechia, larynx and surrounding tissue hemorrhagic edema thereof, and gastric bleeding is red and swollen, is diagnosed as swinery and suffers from pig lung plague.Use the embodiment of the present invention 1 medicine 1 treatment, medicine is sneaked in feedstuff, according to conventional method, feed, each mixed volume is 8% of feedstuff gross weight, uses continuously after three days, and 163 ill pigs recover normal, 37 ill pigs continue to feed and add the feedstuff two days of medicine 1, also all recover normal.
Case 2
Certain self-employed entrepreneurs that raises pigs feeds 10 of growing and fattening pigs, because pigsty is moist, heat, impels pathogenic bacteria to spread rapidly, cause more than fervescence to 41 ℃ appears in 10 pigs inappetence or absolutely useless, dyspnea, there is the symptoms such as purplish-red macula, cervical region edema in skin, is diagnosed as pig lung plague.Use the embodiment of the present invention 2 medicine 2 treatments, medicine is sneaked in feedstuff, according to conventional method, feed, each mixed volume is 6% of feedstuff gross weight, uses continuously after three days, and 10 ill pigs all recover normal.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (7)
1. the medicine that is used for the treatment of pig lung plague, it is characterized in that, described medicine comprises Radix Sophorae Tonkinensis, Lasiosphaera Seu Calvatia, Rhizoma Coptidis, Fructus Gardeniae, Radix Scutellariae, pollen, Fructus Aurantii Immaturus, Radix Et Rhizoma Rhei, Radix Scrophulariae, Radix Gentianae, Caulis Akebiae, Fructus Forsythiae, Radix Platycodonis, Matrii Sulfas Exsiccatus, Bombyx Batryticatus, cup chrysanthemum, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Bulbus Fritillariae Thunbergii, Radix et Rhizoma Thalictri, Semen Arecae and Fructus Aristolochiae.
2. the medicine that is used for the treatment of pig lung plague according to claim 1, it is characterized in that, described medicine is comprised of the crude drug of following parts by weight: Radix Sophorae Tonkinensis 11～20 weight portions, Lasiosphaera Seu Calvatia 11～25 weight portions, Rhizoma Coptidis 11～45 weight portions, Fructus Gardeniae 10～16 weight portions, Radix Scutellariae 10～16 weight portions, pollen 10～15 weight portions, Fructus Aurantii Immaturus 10～15 weight portions, Radix Et Rhizoma Rhei 10～16 weight portions, Radix Scrophulariae 10～20 weight portions, Radix Gentianae 10～15 weight portions, Caulis Akebiae 10～15 weight portions, Fructus Forsythiae 10～20 weight portions, Radix Platycodonis 10～15 weight portions, Matrii Sulfas Exsiccatus 10～15 weight portions, Bombyx Batryticatus 10～15 weight portions, cup chrysanthemum 10～15 weight portions, Semen Lepidii (Semen Descurainiae) 10～15 weight portions, Fructus Perillae 10～20 weight portions, Bulbus Fritillariae Thunbergii 10～15 weight portions, Radix et Rhizoma Thalictri 10～15 weight portions, Semen Arecae 10～15 weight portions and Fructus Aristolochiae 10～15 weight portions.
3. the medicine that is used for the treatment of pig lung plague according to claim 1 and 2, it is characterized in that, described medicine is comprised of the crude drug of following parts by weight: Radix Sophorae Tonkinensis 15 weight portions, Lasiosphaera Seu Calvatia 18 weight portions, Rhizoma Coptidis 29 weight portions, Fructus Gardeniae 13 weight portions, Radix Scutellariae 13 weight portions, pollen 12 weight portions, Fructus Aurantii Immaturus 12 weight portions, Radix Et Rhizoma Rhei 13 weight portions, Radix Scrophulariae 15 weight portions, Radix Gentianae 12 weight portions, Caulis Akebiae 13 weight portions, Fructus Forsythiae 15 weight portions, Radix Platycodonis 13 weight portions, Matrii Sulfas Exsiccatus 13 weight portions, Bombyx Batryticatus 12 weight portions, cup chrysanthemum 12 weight portions, Semen Lepidii (Semen Descurainiae) 13 weight portions, Fructus Perillae 15 weight portions, Bulbus Fritillariae Thunbergii 13 weight portions, Radix et Rhizoma Thalictri 12 weight portions, Semen Arecae 12 weight portions and Fructus Aristolochiae 13 weight portions.
4. according to the medicine that is used for the treatment of pig lung plague described in claim 1-3 any one, it is characterized in that, described medicine also comprises Semen coryli heterophyllae, Stigma Maydis, Folium Symplocoris Caudatae, rock wind and Radix Glycyrrhizae.
5. according to the medicine that is used for the treatment of pig lung plague described in claim 1-4 any one, it is characterized in that, described medicine is comprised of the crude drug of following ratio of weight and number: Radix Sophorae Tonkinensis 15～20 weight portions, Lasiosphaera Seu Calvatia 12～25 weight portions, Rhizoma Coptidis 20～35 weight portions, Fructus Gardeniae 10～16 weight portions, Radix Scutellariae 10～16 weight portions, pollen 10～15 weight portions, Fructus Aurantii Immaturus 10～15 weight portions, Radix Et Rhizoma Rhei 10～16 weight portions, Radix Scrophulariae 11～15 weight portions, Radix Gentianae 11～15 weight portions, Caulis Akebiae 11～15 weight portions, Fructus Forsythiae 11～15 weight portions, Radix Platycodonis 11～15 weight portions, Matrii Sulfas Exsiccatus 10～15 weight portions, Bombyx Batryticatus 10～15 weight portions, cup chrysanthemum 11～15 weight portions, Semen Lepidii (Semen Descurainiae) 10～15 weight portions, Fructus Perillae 11～18 weight portions, Bulbus Fritillariae Thunbergii 11～15 weight portions, Radix et Rhizoma Thalictri 11～15 weight portions, Semen Arecae 11～15 weight portions, Fructus Aristolochiae 11～14 weight portions, Semen coryli heterophyllae 11～14 weight portions, Stigma Maydis 10～15 weight portions, Folium Symplocoris Caudatae 11～14 weight portions, rock wind 10～15 weight portions and Radix Glycyrrhizae 15～35 weight portions.
6. according to the medicine that is used for the treatment of pig lung plague described in claim 1-5 any one, it is characterized in that, described medicine is comprised of the crude drug of following ratio of weight and number: Radix Sophorae Tonkinensis 18 weight portions, Lasiosphaera Seu Calvatia 19 weight portions, Rhizoma Coptidis 32 weight portions, Fructus Gardeniae 13 weight portions, Radix Scutellariae 13 weight portions, pollen 12 weight portions, Fructus Aurantii Immaturus 12 weight portions, Radix Et Rhizoma Rhei 13 weight portions, Radix Scrophulariae 13 weight portions, Radix Gentianae 13 weight portions, Caulis Akebiae 12 weight portions, Fructus Forsythiae 13 weight portions, Radix Platycodonis 13 weight portions, Matrii Sulfas Exsiccatus 12 weight portions, Bombyx Batryticatus 12 weight portions, cup chrysanthemum 13 weight portions, Semen Lepidii (Semen Descurainiae) 13 weight portions, Fructus Perillae 15 weight portions, Bulbus Fritillariae Thunbergii 13 weight portions, Radix et Rhizoma Thalictri 13 weight portions, Semen Arecae 13 weight portions, Fructus Aristolochiae 12 weight portions, Semen coryli heterophyllae 13 weight portions, Stigma Maydis 12 weight portions, Folium Symplocoris Caudatae 13 weight portions, rock wind 13 weight portions and Radix Glycyrrhizae 25 weight portions.
7. a preparation method for the medicine that is used for the treatment of pig lung plague as described in claim 1-6 any one, is characterized in that, described preparation method comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials material, after mixing, be ground into powder;
Second step, the first step is obtained to powder add in cold water and soak 24 hours～36 hours, with slow fire boiling, decocting time is 2 hours～3 hours, and decoction liquor is filtered, obtain the first filtrate, the quality of the water adding is 3～5 times of the powder quality that obtains of the first step;
The 3rd step, the filtering residue that second step filter is obtained add in cold water again, with slow fire boiling 2～4 times, decoct 1 hour～2 hours at every turn, filter and merge filtrate, obtain the second filtrate, identical in the quality of the water adding and second step;
The 4th step, the first filtrate and the second filtrate are merged, concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, dry cream is put into spray dryer dry, guarantee that inlet temperature is at 170 ℃～190 ℃, 60 ℃～80 ℃ of leaving air temps, be ground into subsequently 200 order～400 orders, obtain drug powder.
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| CN103948690A (en) * | 2014-05-12 | 2014-07-30 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicinal composition for preventing and treating cough asthma due to lung-heat of chicken |
| CN104351563A (en) * | 2014-11-27 | 2015-02-18 | 山东新希望六和集团有限公司 | Functional feed used for preventing pig malignant edema and preparation method of functional feed |
| CN107048008A (en) * | 2017-03-14 | 2017-08-18 | 滁州菲扬农业科技有限公司 | A kind of feed addictive and preparation method for preventing and treating swine plague |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103948690A (en) * | 2014-05-12 | 2014-07-30 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicinal composition for preventing and treating cough asthma due to lung-heat of chicken |
| CN103948690B (en) * | 2014-05-12 | 2016-01-20 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of Chinese medicine composition for preventing and treating chicken lung-heat cough with asthma |
| CN104351563A (en) * | 2014-11-27 | 2015-02-18 | 山东新希望六和集团有限公司 | Functional feed used for preventing pig malignant edema and preparation method of functional feed |
| CN107048008A (en) * | 2017-03-14 | 2017-08-18 | 滁州菲扬农业科技有限公司 | A kind of feed addictive and preparation method for preventing and treating swine plague |
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