For treating the feedstuff of rabbit coccidiosis
Technical field
The present invention relates to field of feed additive technology, particularly relate to a kind of feedstuff for treating rabbit coccidiosis.
Background technology
Rabbit coccidiosis is to be parasitized Hepar Leporis seu Oryctolagi bile duct and enterocyte by the multiple coccidiosis of Eimeria, and cause internal
Parasitic disease.Coccidiosis is a kind of endobiosis parasitosis that harm 30~70 age in days children rabbits are the most serious.The coccidium infection of children rabbit
Rate is 90%, and mortality rate is 60%.The sick rabbit initial stage shows as loss of appetite, does not like activity, and two dull, and at eye nose, secretions increases
Many, anemia, dysentery, become thin, sometimes suffer from diarrhoea or suffer from diarrhoea and constipation is alternately present, growth retardation.Time seriously ill, suffer from rabbit and fall down suddenly,
Muscle spasm, hind leg is tetanic, and forelimb makees imperious paddling, and head, to layback, utters a heartrending cry sound and dead.The distribution of this disease is wide, biography
Broadcasting fast, mortality rate height, the rabbit of different cultivars is all had susceptibility, provisions rabbit industry brings huge economic loss.Resistance to ball excessively
Parasitosis is dead, or rabbit through curing becomes long-term carrier, and becomes the source of infection of this disease.
Not yet developing rabbit coccidial vaccine at present, the main method of preventing and treating rabbit coccidiosis remains application anticoccidial both at home and abroad
Medicine.In feedstuff add coccidiostat, be the major measure treating rabbit coccidiosis at present, for coccidiosis medicine very
Many, from sulfa drugs the earliest to Salinomycin and Maduramicin plasma carrier class medicine, it is complete, but these
Anticoccidial drug all also exists defect more or less, and some drug toxicitys are big, and safety range is little, and some easily produces drug resistance,
The application time the shortest some can not use with other medicines simultaneously, anticoccidial drugs numerous on the market, raiser is the most not
Knowing and arranged, blindly application, frequently changes dressings, causes coccidiosis obstinate.From the end of the year 2008, in France, Italy and Spain
Diclazuril has authorized rabbit feed addictive, but, the coccidiostat developed according to Eimeria species pattern, have to rabbit ball
Worm is the most inoperative.It is usually used in preventing the active drug of rabbit coccidiosis to have Robenidine, diclazuril and Salinomycin;Medicine has
Sulfa drugs and Toltrazuril.
Rabbit coccidiosis belongs to the category of malnutrition due to parasitic infestation Chinese veterinarian, should can reach preventing and treating coccidiosis with heat-clearing and toxic substances removing, parasite killing medical herbs
Effect, meanwhile, by improve immunity of organisms medicine improve ill chicken resistance against diseases, the most reticuloendothelial
Function, delays Drug resistance to produce.Use Chinese herbal treatment rabbit coccidiosis, be on the one hand the growth of suppression coccidiosis, be on the other hand
By regulating the resistance function of animal body, breed and occur nonspecific resistance to strengthen body disease-resistant power, arrive and eliminate
Pathogen and slow down its damage for cell, recovers the purpose of the normal physiological function of body.
Chinese herbal medicine mostly is natural plants, uses herbal control coccidiosis, both can reach the purpose of preventing and treating coccidiosis, and overcome again
Frequent application anticoccidial drug and the residue of veterinary drug drawback brought, and it is not likely to produce drug resistance, do not cause environmental pollution.This
The Chinese herbal medicine of bright offer passes through parasite killing anthelmintic, bangle removing toxic substances, cooling blood for hemostasis, raising immunity of organisms, can alleviate because of ball
Hemorrhage, the dysentery that parasitosis causes, the effect such as enhancing body resistance, reaches effect for the treatment of both the principal and secondary aspects of a disease again.
Summary of the invention
The technical problem to be solved is to provide a kind of medicine for treating rabbit coccidiosis and feedstuff, and using should
Feedstuff can alleviate hemorrhage, the dysentery caused because of coccidiosis, and the effect such as enhancing body resistance, reaches the merit for the treatment of both the principal and secondary aspects of a disease again
Imitate, and this medicine has no side effect, delays drug resistance, drug residue free, be that prevention coccidiosis well selects.
For solve above-mentioned technical problem, the invention provides a kind of feedstuff for treating rabbit coccidiosis, it include for
The treatment drug powder of rabbit coccidiosis, Semen Maydis, rice chaff, bean cake, Testa Tritici, fish flour, bone meal and Sal.
Wherein, in described feedstuff the weight of each raw material be respectively drug powder 1.2kg~1.8kg, Semen Maydis 45kg~55kg,
Rice chaff 27kg~33kg, bean cake 12kg~18kg, Testa Tritici 8kg~12kg, fish flour 2kg~4kg, bone meal 1kg~3kg, Sal
0.5kg~1.5kg.
Wherein, in described feedstuff, the weight of each raw material is respectively drug powder 1.5kg, Semen Maydis 50kg, rice chaff 20kg, bean cake
15kg, Testa Tritici 10kg, fish flour 3kg, bone meal 2kg, Sal 1kg.
Wherein, the crude drug of described drug powder includes the Radix Pulsatillae, Radix Sanguisorbae, Flos Lonicerae, Radix Glycyrrhizae, passes through muscle rattan, Herba Imperata cylindrica, goose
BUSHICAO, Herba Lobeliae Chinensis, Resina Ferulae, Gaultheria, Folium Symplocoris Caudatae, Folium Viticis Negundo, Caulis Sargentodoxae, the Radix Stemonae, Semen Torreyae, Rhizoma Coptidis, Cortex Ailanthi, Bulbus Allii, Ba Ji
My god, Fructus Choerospondiatis, Radix Campanumoeae, Semen Myristicae, Galla Chinensis, Folium Isatidis, Concretio silicea Bambusae seu schizostachyi, Herba Taxilli and Radix Scrophulariae.
Wherein, in described drug powder, the weight of each raw material is respectively the Radix Pulsatillae 15g~25g, Radix Sanguisorbae 15g~25g, gold silver
Spend 35g~45g, Radix Glycyrrhizae 15g~25g, pass through muscle rattan 15g~25g, Herba Imperata cylindrica 5g~15g, Herba Centipedae 5g~15g, Herba Lobeliae Chinensis
25g~35g, Resina Ferulae 5g~15g, Gaultheria 15g~25g, Folium Symplocoris Caudatae 15g~25g, Folium Viticis Negundo 15g~25g, Caulis Sargentodoxae 5g~
15g, the Radix Stemonae 15g~25g, Semen Torreyae 15g~25g, Rhizoma Coptidis 35g~45g, Cortex Ailanthi 15g~25g, Bulbus Allii 15g~25g, Radix Morindae Officinalis
15g~25g, Fructus Choerospondiatis 15g~25g, Radix Campanumoeae 35g~45g, Semen Myristicae 15g~25g, Galla Chinensis 25g~35g, Folium Isatidis
25g~35g, Concretio silicea Bambusae seu schizostachyi 5g~15g, Herba Taxilli 25g~35g, Radix Scrophulariae 25g~35g.
Wherein, in described drug powder, the weight of each raw material is respectively the Radix Pulsatillae 18g~22g, Radix Sanguisorbae 18g~22g, gold silver
Spend 38g~42g, Radix Glycyrrhizae 18g~22g, pass through muscle rattan 18g~22g, Herba Imperata cylindrica 8g~12g, Herba Centipedae 8g~12g, Herba Lobeliae Chinensis
28g~32g, Resina Ferulae 8g~12g, Gaultheria 18g~22g, Folium Symplocoris Caudatae 18g~22g, Folium Viticis Negundo 18g~22g, Caulis Sargentodoxae 8g~
12g, the Radix Stemonae 18g~22g, Semen Torreyae 18g~22g, Rhizoma Coptidis 38g~42g, Cortex Ailanthi 18g~22g, Bulbus Allii 18g~22g, Radix Morindae Officinalis
18g~22g, Fructus Choerospondiatis 18g~22g, Radix Campanumoeae 38g~42g, Semen Myristicae 18g~22g, Galla Chinensis 28g~32g, Folium Isatidis
28g~32g, Concretio silicea Bambusae seu schizostachyi 8g~12g, Herba Taxilli 28g~32g, Radix Scrophulariae 28g~32g.
Wherein, in described drug powder, the weight of each raw material is respectively Radix Pulsatillae 20g, Radix Sanguisorbae 20g, Flos Lonicerae 40g, Radix Glycyrrhizae
20g, pass through muscle rattan 20g, Herba Imperata cylindrica 10g, Herba Centipedae 10g, Herba Lobeliae Chinensis 30g, Resina Ferulae 10g, Gaultheria 20g, Folium Symplocoris Caudatae 20g, male
Jing Ye 20g, Caulis Sargentodoxae 10g, Radix Stemonae 20g, Semen Torreyae 20g, Rhizoma Coptidis 40g, Cortex Ailanthi 20g, Bulbus Allii 20g, Radix Morindae Officinalis 20g, Fructus Choerospondiatis
20g, Radix Campanumoeae 40g, Semen Myristicae 20g, Galla Chinensis 30g, Folium Isatidis 30g, Concretio silicea Bambusae seu schizostachyi 10g, Herba Taxilli 30g, Radix Scrophulariae 30g.
Present invention also offers the preparation method of described feedstuff, particularly as follows:
The first step, pulverizes each crude drug respectively, is mixed in proportion, and mixture loads in percolator, and every 500g adds 50
Degree~Chinese liquor 800g~1000g of 55 degree, soak 20 hours~30 hours under conditions of 30 DEG C~40 DEG C, regulates percolator valve
Door, makes Chinese liquor medicinal liquid slowly ooze, and to ooze speed be per minute 2~4mL, to the color oozed transparent, collect and ooze
Drip, obtains percolate, concentrates, and removes Chinese liquor, dry, pulverize, it is thus achieved that the drug powder being dried;
Second step, the drug powder each for remaining in described feedstuff component and the first step prepared is sent in blender,
Stirring 30 minutes~1 hour at normal temperatures, it is thus achieved that feedstuff.
Beneficial effects of the present invention:
The present invention provides a kind of medicine for treating rabbit coccidiosis and feedstuff, uses this medicine can alleviate because of coccidiosis
Hemorrhage, the dysentery caused, the effect such as enhancing body resistance, reaches effect for the treatment of both the principal and secondary aspects of a disease again, and this medicine has no side effect,
Delay drug resistance, drug residue free, be that prevention coccidiosis well selects.
Detailed description of the invention
The invention provides a kind of medicine for treating rabbit coccidiosis, its crude drug includes the Radix Pulsatillae, Radix Sanguisorbae, gold silver
Flower, Radix Glycyrrhizae, pass through muscle rattan, Herba Imperata cylindrica, Herba Centipedae, Herba Lobeliae Chinensis, Resina Ferulae, Gaultheria, Folium Symplocoris Caudatae, Folium Viticis Negundo, Caulis Sargentodoxae, the Radix Stemonae,
Semen Torreyae, Rhizoma Coptidis, Cortex Ailanthi, Bulbus Allii, Radix Morindae Officinalis, Fructus Choerospondiatis, Radix Campanumoeae, Semen Myristicae, Galla Chinensis, Folium Isatidis, Concretio silicea Bambusae seu schizostachyi, Herba Taxilli and profound
Ginseng.
Further, described medicine is only made up of above-mentioned raw materials medicine.
In described medicine the weight of each raw material be respectively the Radix Pulsatillae 15g~25g, Radix Sanguisorbae 15g~25g, Flos Lonicerae 35g~
45g, Radix Glycyrrhizae 15g~25g, pass through muscle rattan 15g~25g, Herba Imperata cylindrica 5g~15g, Herba Centipedae 5g~15g, Herba Lobeliae Chinensis 25g~35g,
Resina Ferulae 5g~15g, Gaultheria 15g~25g, Folium Symplocoris Caudatae 15g~25g, Folium Viticis Negundo 15g~25g, Caulis Sargentodoxae 5g~15g, the Radix Stemonae
15g~25g, Semen Torreyae 15g~25g, Rhizoma Coptidis 35g~45g, Cortex Ailanthi 15g~25g, Bulbus Allii 15g~25g, Radix Morindae Officinalis 15g~25g,
Fructus Choerospondiatis 15g~25g, Radix Campanumoeae 35g~45g, Semen Myristicae 15g~25g, Galla Chinensis 25g~35g, Folium Isatidis 25g~35g, bamboo
Yellow 5g~15g, Herba Taxilli 25g~35g, Radix Scrophulariae 25g~35g.
Further preferably, in described medicine, the weight of each raw material is respectively the Radix Pulsatillae 18g~22g, Radix Sanguisorbae 18g~22g, gold
Flos Lonicerae 38g~42g, Radix Glycyrrhizae 18g~22g, pass through muscle rattan 18g~22g, Herba Imperata cylindrica 8g~12g, Herba Centipedae 8g~12g, Herba Lobeliae Chinensis
28g~32g, Resina Ferulae 8g~12g, Gaultheria 18g~22g, Folium Symplocoris Caudatae 18g~22g, Folium Viticis Negundo 18g~22g, Caulis Sargentodoxae 8g~
12g, the Radix Stemonae 18g~22g, Semen Torreyae 18g~22g, Rhizoma Coptidis 38g~42g, Cortex Ailanthi 18g~22g, Bulbus Allii 18g~22g, Radix Morindae Officinalis
18g~22g, Fructus Choerospondiatis 18g~22g, Radix Campanumoeae 38g~42g, Semen Myristicae 18g~22g, Galla Chinensis 28g~32g, Folium Isatidis
28g~32g, Concretio silicea Bambusae seu schizostachyi 8g~12g, Herba Taxilli 28g~32g, Radix Scrophulariae 28g~32g.
Most preferably, in described medicine, the weight of each raw material is respectively Radix Pulsatillae 20g, Radix Sanguisorbae 20g, Flos Lonicerae 40g, Radix Glycyrrhizae
20g, pass through muscle rattan 20g, Herba Imperata cylindrica 10g, Herba Centipedae 10g, Herba Lobeliae Chinensis 30g, Resina Ferulae 10g, Gaultheria 20g, Folium Symplocoris Caudatae 20g, male
Jing Ye 20g, Caulis Sargentodoxae 10g, Radix Stemonae 20g, Semen Torreyae 20g, Rhizoma Coptidis 40g, Cortex Ailanthi 20g, Bulbus Allii 20g, Radix Morindae Officinalis 20g, Fructus Choerospondiatis
20g, Radix Campanumoeae 40g, Semen Myristicae 20g, Galla Chinensis 30g, Folium Isatidis 30g, Concretio silicea Bambusae seu schizostachyi 10g, Herba Taxilli 30g, Radix Scrophulariae 30g.
Present invention also offers the preparation method of said medicine, particularly as follows:
Being pulverized respectively by each crude drug, be mixed in proportion, mixture loads in percolator, and every 500g adds 50 degree~55 degree
Chinese liquor 800g~1000g, under conditions of 30 DEG C~40 DEG C soak 20 hours~30 hours, regulate percolator valve, make white
Yeast for brewing rice wine liquid slowly oozes, and oozing speed is per minute 2~4mL, to the color oozed transparent, collect the drip that oozes,
Obtain percolate, concentrate, remove Chinese liquor, dry, pulverize, it is thus achieved that the drug powder being dried.
The present invention also provides for a kind of feedstuff for treating rabbit coccidiosis, and it includes above-mentioned drug powder, Semen Maydis, rice
Bran, bean cake, Testa Tritici, fish flour, bone meal and Sal.
Further, described feedstuff is only made up of above-mentioned raw materials.
In described feedstuff, the weight of each raw material is respectively drug powder 1.2kg~1.8kg, Semen Maydis 45kg~55kg, rice chaff
27kg~33kg, bean cake 12kg~18kg, Testa Tritici 8kg~12kg, fish flour 2kg~4kg, bone meal 1kg~3kg, Sal 0.5kg~
1.5kg。
In described feedstuff the weight of each raw material be respectively drug powder 1.5kg, Semen Maydis 50kg, rice chaff 20kg, bean cake 15kg,
Testa Tritici 10kg, fish flour 3kg, bone meal 2kg, Sal 1kg.
Present invention also offers the preparation method of described feedstuff, particularly as follows:
The first step, prepares described drug powder according to above method;
Second step, the drug powder each for remaining in described feedstuff component and the first step prepared is sent in blender,
Stirring 30 minutes~1 hour at normal temperatures, it is thus achieved that feedstuff.
Each crude drug pharmacology is as follows:
The Radix Pulsatillae: bitter in the mouth, cold in nature, enter stomach, large intestine channel, have the effect of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, being mainly used in the intestines and stomach has
Damp and hot stagnant heating is suffered from abdominal pain, dysentery pus and blood, the treatment of the symptoms such as tenesmus, to the hematodiarrhoea hematochezia effect of large intestine heat in blood relatively
Good, dysentery bacterium, Bacillus typhi, bacillus subtilis, escherichia coli, Staphyloccocus aureus are all had certain suppression to make by the Radix Pulsatillae
With.
Radix Sanguisorbae: bitter in the mouth, acid, cold in nature, return liver;Lung;Kidney;Large intestine channel, has a cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore
Effect, cures mainly haematemesis, spitting of blood, epistaxis, and hematuria is had blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, leucorrhea with red and white discharge, sore, carbuncle and painful swelling, eczema, pudendal pruritus,
Burn due to hot liquid or fire, snake bite and insect sting etc. is demonstrate,proved.
Flos Lonicerae: latin name lonicerae japonicae flos, has another name called Flos Lonicerae, Flos Lonicerae, Flos Lonicerae, two precious flowers, taste
Sweet, cold in nature, enter the heart, lung, stomach, large intestine channel, have the effect of heat-clearing and toxic substances removing, energy eliminating pathogenic heat from blood to cure dysentery of holding concurrently, it is mainly used in affection due to external wind and heat, warm
Febrile disease poison is relatively contained, or when epidemic febrile disease is still the most descending at the part of the body cavity above the diaphragm housing the heart and lungs from the beginning of pathogenic heat;Pyretic toxicity dysentery, stool hematochezia;Fever disease in summer is demonstrate,proved;Pyretic toxicity gathers
Carbuncle sore from the beginning of, the heat person of swelling and ache, and other skin infections, this thing has preferable antipyretic effect, has antiinflammatory action, can promote
The phagocytic function of leukocyte, has stronger bacteriostasis to multiple pyococcus and pathogenic entero becteria.
Radix Glycyrrhizae: sweet in the mouth, property puts down, enters 12 warps, have a heat-clearing and toxic substances removing, is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and
In, relieving spasm to stop pain, it is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak;Contracture pain in abdomen can be alleviated, relax some drugs
Strong and toxicity, alleviate medicine to the toxic and side effects of body or to gastrointestinal stimulate, by add Radix Glycyrrhizae can play QI invigorating
Neutralize, be in harmonious proportion the effect of each component.
Passing through muscle rattan: pass through the Herb of muscle rattan, mildly bitter flavor for trailing plants section Herba Dregeae volubilis platymiscium, property is put down, have dispel the wind, dampness removing, drench
Disease, edema, agalactia, exogenous injury etc. is demonstrate,proved.
Herba Imperata cylindrica: sweet in the mouth, property are flat, has hemostasis, effect of removing toxic substances, cures mainly hematuria, fecal blood, traumatic hemorrhage, carbuncle sore
Toxic swellings etc. are demonstrate,proved.
Herba Centipedae: acrid in the mouth, warm in nature, enter lung, Liver Channel, there is cold-dispelling, clearing the nasal passage, eliminating phlegm and stopping cough, the work of dissipating blood stasis for subsidence of swelling
With, for exterior syndrome due to wind-cold, nasal obstruction watery nasal discharge and nasal sinusitis, cough with copious phlegm, pertussis, sore, carbuncle and painful swelling etc. is demonstrate,proved.
Herba Lobeliae Chinensis: latin name Lobeliae Chinensis Herba, acrid in the mouth, property is flat, GUIXIN, small intestinal, lung meridian, has clear
Thermal detoxification, effect of inducing diuresis to remove edema, cure mainly the cards such as snake bite and insect sting, jaundice due to damp-heat, eczema eczema, carbuncle furuncle.
Resina Ferulae: bitter in the mouth, pungent, warm in nature, to return kidney, stomach warp, there is removing food stagnancy, dissipate painful abdominal mass, effect of parasite killing, for meat stagnation, the stasis of blood
Mass formed by blood stasis abdominal mass, mass in abdomen, abdominal pain due to worm stagnation etc. is demonstrate,proved.
Gaultheria: for root or the stem and leaf of Ericaceae Gaultheria plant white strain tree, acrid in the mouth, puckery, warm in nature, gas is fragrant, tool
Having effect of expelling wind and removing dampness, cure mainly rheumatic arthritis, traumatic injury etc. is demonstrate,proved.
Folium Symplocoris Caudatae: for the leaf of vitriol platymiscium mountain, Symplocaceae mountain vitriol, sour in the mouth, puckery, micro-sweet, property is put down, and has heat-clearing and toxic substances removing, under
Gas, effect of hemostasis, cure mainly chronic dysentery, wind-fire acute conjunctivitis, tonsillitis, otitis media, cough, vomiting, hemoptysis, have blood in stool to wait and demonstrate,prove.
Folium Viticis Negundo: latin name Viticis NegundoFolium, acrid in the mouth;Bitter;Property flat, return lung meridian, there is removing dampness of inducing sweat,
Eliminating phlegm and relieving asthma;Removing toxic substances, expelling pathogenic wind from the body surface, dehumidifying, parasite killing, effect of pain relieving, cure mainly Common Cold, cough, asthma;Stomachache;Stomachache;
Heat-damp in summer dysentery;Tinea pedis swelling;Rubella pruritus;Tinea pedis;Acute mastitis swells and ache;Snake bite and insect stings etc. are demonstrate,proved.
Caulis Sargentodoxae: bitter in the mouth, property is put down, is returned liver, large intestine channel, has the eliminating carbuncle that relieves internal heat, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide, master
Controlling acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, injury from falling down etc. is demonstrate,proved.
The Radix Stemonae: sweet in the mouth, hardship, slightly warm in nature, enters lung meridian, has a nourishing the lung to arrest cough, the effect of delousing parasite killing, the Radix Stemonae gentle and not
Dry, property is kept and is not walked, and has again the merit of using pungent drugs for dispersion and bitter drugs for purgation sending down the abnormal ascending QI, is mainly used in the most all coughing, is especially suitable to consumptive fever chronic cough person, and the modern times are used for preventing and treating
The cough of chronic bronchitis, the dry cough of pulmonary tuberculosis, pertussis etc. is demonstrate,proved.
Semen Torreyae: latin name Torreyae Semen, sweet in the mouth, property is put down, is returned lung, stomach, large intestine channel, have killing insect and eliminating accumulation, lung moistening
Cough-relieving, effect of loosening bowel to relieve constipation, cure mainly ancylostomiasis, ascariasis, abdominal pain due to worm stagnation, infantile malnutrition, soap cough, constipation etc.
Card.
Rhizoma Coptidis: bitter in the mouth, cold in nature, enter the heart, lung, gallbladder, stomach, large intestine channel, have heat clearing and damp drying, eliminating fire and detoxication, the work of cooling blood for improving eyesight
With, it is usually used in treating the fire of removing pathogen in the heart warp, the dysphoria and insomnia that heart-fire is prosperous, and the high fever coma of epidemic febrile disease, the symptom such as vexed, thirsty.
Cortex Ailanthi: bitter in the mouth, puckery, cold in nature, enter large intestine, stomach, Liver Channel, there is heat clearing and damp drying, astringing intestine to stop diarrhea leukorrhagia stopping, hemostasis, the work of parasite killing
With, for damp-heat dysentery, chronic diarrhea chronic dysentery, metrorrhagia, to have blood in stool, hemorrhoid hematochezia, leukorrhagia, discharging fresh blood stool etc. is demonstrate,proved.
Bulbus Allii: warm in nature, acrid in the mouth is put down;Enter spleen, stomach, lung meridian, there is warming middle-JIAO and help digestion, row stagnant gas, warming the spleen and stomach, removing food stagnancy, detoxify, kill
Effect of worm, cure mainly eating accumulation, coldness and pain in the epigastrium, edema distension, have loose bowels, dysentery, malaria, pertussis, swollen ulcer drug, white bald tinea
Skin ulcer, snake bite and insect sting and the disease such as ancylostome, pinworm.
Radix Morindae Officinalis: latin name Morindae Officinalis Radix, acrid in the mouth, sweet, slightly warm in nature, enter liver, kidney channel, have
Kidney-replenishing, bone and muscle strengthening, effect of wind-damp dispelling, for impotence due to deficiency of the kidney, seminal emission premature ejaculation, few abdomen cold type of pain, cold womb is infertile, deficiency of the liver and kindey institute
The cards such as soft, the chills and pain of the waist and kness of muscles and bones flaccidity caused.
Fructus Choerospondiatis: sweet in the mouth, acid, property is put down, and has promoting flow of QI and blood, tranquilizing by nourishing the heart, effect of removing food stagnancy removing toxic substances, cures mainly stagnation of QI blood
The stasis of blood, chest pain, shortness of breath and palpitation, neurasthenia, insomnia, bronchitis, dyspepsia abdominal distention, diarrhoea etc. is demonstrate,proved.
Radix Campanumoeae: latin name radix campanumoea javanicae, for campanulaceae leopard platymiscium Flos Caryophylli money
Leopard and the root of leopard, sweet in the mouth, property is flat, returns lung, spleen channel, has invigorating the spleen and benefiting QI, tonifying the lung and stopping cough, and effect of stimulating milk secretion cures mainly labor empty
Internal injury, the cards such as the deficiency of vital energy is weak, cardiopalmus, hyperhidrosis, diarrhea due to hypofunction of the spleen, leucorrhea, and milk is rare, insufficiency of the spleen cough.
Semen Myristicae: latin name Myristicae Semen, acrid in the mouth, hardship, warm in nature, enter spleen, stomach, large intestine channel, there is warming middle-JIAO puckery
The effect that intestinal, circulation of qi promoting help digestion, demonstrate,proves for diarrhea of deficiency type, cold-dysentery, abdominal distention, lack of appetite is vomitted, dyspepsia does not disappear etc..
Galla Chinensis: latin name Galla Chinensis, sour in the mouth, puckery, cold in nature, return lung, large intestine, kidney channel, there is convergence solid
Puckery, supplementing QI for promoting the production of body fluid, effect of kidney calming, cure mainly: chronic cough of deficiency lung;Spontaneous sweating;Chronic dysentery chronic diarrhea;Proctoptosis;Seminal emission;Nebulousurine;Respectively
Plant hemorrhage;Carbuncle furuncle etc. are demonstrate,proved, and the Galla Chinensis energy enhancing body defence capability to nonspecific stimulation can strengthen the immunity of cell
This pathogenic bacterium are had inhibitory action by function, and can antiviral growth.
Folium Isatidis: latin name Isatidis Folium, bitter in the mouth, property Great Cold, GUIXIN, liver, gallbladder, stomach warp, have antipyretic and detoxicated,
Cooling blood and dissolving purpura, effect of jaundice eliminating, can the excess-heat that divides of clearing heat in QI system, the pyretic toxicity of blood system can be solved again, be mainly used in pestilence calentura caused it
High febrile perspiration goes out, excessive thirst taking fluids profusely;The symptoms such as the speckle that fire-toxin is flourishing is gone mad, haematemesis;The unconsciousness due to high fever of measles, rash color is purple dark;Liver and gall
The damp and hot jaundice accumulateing steaming;The deafness and tinnitus of liver and gall fire liter;The cards such as the caused pharyngalgia of fire stagnation pyretic toxicity, aphtha of the mouth and tongue, hepatitis.
Concretio silicea Bambusae seu schizostachyi: lightly seasoned, property is put down, is had preventing phlegm from forming and stopping coughing, promoting blood circulation to remove blood stasis, effect of expelling wind and removing dampness, cure mainly cough ant phlegm, one hundred days
Coughing, leukorrhagia, stomachache, rheumatic arthralgia, infantile convulsion, traumatic injury etc. is demonstrate,proved.
Herba Taxilli: bitter in the mouth, sweet, property is put down, and enters liver, kidney channel, has invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, the effect of antiabortive unit,
For the soreness of waist pain caused by deficiency of the liver and kindey, muscles and bones flaccidity is soft, the foot and knee being feeble, deficiency of the liver and kindey, and essence and blood void is lost, the fetal movement of liability to abortion
Uneasiness, waist abdomen pain etc. is demonstrate,proved.
Radix Scrophulariae: sweet in the mouth, hardship, one-tenth, cold nature, returns lung, stomach, kidney channel, has clearing away heat and cooling blood, eliminating fire and detoxication, and YIN nourishing is for nourishing kidney
Effect, cures mainly pathogenic warmth and joins the army, and cave in pericardium, maculae caused by violent heat pathogen, consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin hinder constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion,
Pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus etc. are demonstrate,proved.
Embodiment is below used to describe embodiments of the present invention in detail, whereby to the present invention how application technology means
Solve technical problem, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1 drug powder 1
By Radix Pulsatillae 20g, Radix Sanguisorbae 20g, Flos Lonicerae 40g, Radix Glycyrrhizae 20g, pass through muscle rattan 20g, Herba Imperata cylindrica 10g, Herba Centipedae
10g, Herba Lobeliae Chinensis 30g, Resina Ferulae 10g, Gaultheria 20g, Folium Symplocoris Caudatae 20g, Folium Viticis Negundo 20g, Caulis Sargentodoxae 10g, Radix Stemonae 20g, Semen Torreyae
20g, Rhizoma Coptidis 40g, Cortex Ailanthi 20g, Bulbus Allii 20g, Radix Morindae Officinalis 20g, Fructus Choerospondiatis 20g, Radix Campanumoeae 40g, Semen Myristicae 20g, Galla Chinensis
30g, Folium Isatidis 30g, Concretio silicea Bambusae seu schizostachyi 10g, Herba Taxilli 30g and Radix Scrophulariae 30g pulverize respectively, are mixed in proportion, and mixture loads percolator
In, every 500g adds the Chinese liquor 1000g of 50 degree, soaks 30 hours under conditions of 30 DEG C, regulates percolator valve, makes Chinese liquor medicine
Liquid slowly oozes, and oozing speed is 3mL per minute, to the color oozed transparent, collect the drip that oozes, obtain percolation
Liquid, concentrates, and removes Chinese liquor, dry, pulverize, it is thus achieved that the drug powder 1 being dried.
Embodiment 2 drug powder 2
By Radix Pulsatillae 18g, Radix Sanguisorbae 18g, Flos Lonicerae 38g, Radix Glycyrrhizae 18g, pass through muscle rattan 18g, Herba Imperata cylindrica 8g, Herba Centipedae 8g,
Herba Lobeliae Chinensis 28g, Resina Ferulae 8g, Gaultheria 18g, Folium Symplocoris Caudatae 18g, Folium Viticis Negundo 18g, Caulis Sargentodoxae 8g, Radix Stemonae 18g, Semen Torreyae 18g, Rhizoma Coptidis
38g, Cortex Ailanthi 18g, Bulbus Allii 18g, Radix Morindae Officinalis 18g, Fructus Choerospondiatis 18g, Radix Campanumoeae 38g, Semen Myristicae 18g, Galla Chinensis 28g, Folium Isatidis
28g, Concretio silicea Bambusae seu schizostachyi 8g, Herba Taxilli 28g and Radix Scrophulariae 28g pulverize respectively, are mixed in proportion, and mixture loads in percolator, and every 500g adds
Enter the Chinese liquor 1000g of 50 degree, soak 30 hours under conditions of 30 DEG C, regulate percolator valve, make Chinese liquor medicinal liquid slowly ooze,
Oozing speed is 3mL per minute, to the color oozed transparent, collect the drip that oozes, obtain percolate, concentrate, remove
Chinese liquor, dry, pulverize, it is thus achieved that the drug powder 2 being dried.
Embodiment 3 drug powder 3
By Radix Pulsatillae 22g, Radix Sanguisorbae 22g, Flos Lonicerae 42g, Radix Glycyrrhizae 22g, pass through muscle rattan 22g, Herba Imperata cylindrica 12g, Herba Centipedae
12g, Herba Lobeliae Chinensis 32g, Resina Ferulae 12g, Gaultheria 22g, Folium Symplocoris Caudatae 22g, Folium Viticis Negundo 22g, Caulis Sargentodoxae 12g, Radix Stemonae 22g, Semen Torreyae
22g, Rhizoma Coptidis 42g, Cortex Ailanthi 22g, Bulbus Allii 22g, Radix Morindae Officinalis 22g, Fructus Choerospondiatis 22g, Radix Campanumoeae 42g, Semen Myristicae 22g, Galla Chinensis
32g, Folium Isatidis 32g, Concretio silicea Bambusae seu schizostachyi 12g, Herba Taxilli 32g and Radix Scrophulariae 32g pulverize respectively, are mixed in proportion, and mixture loads percolator
In, every 500g adds the Chinese liquor 1000g of 50 degree, soaks 30 hours under conditions of 30 DEG C, regulates percolator valve, makes Chinese liquor medicine
Liquid slowly oozes, and oozing speed is 3mL per minute, to the color oozed transparent, collect the drip that oozes, obtain percolation
Liquid, concentrates, and removes Chinese liquor, dry, pulverize, it is thus achieved that the drug powder 3 being dried.
Embodiment 4 toxicity test
Embodiment 4 pharmacological toxicity is tested
Acute toxicity test data
Detectable
Serum AST, ALT detection kit are purchased from Rui Sheng bio tech ltd, Qingdao
Detection equipment
Micro-200 semiautomatic biochemistry detector, analytical balance, dissecting instrument, syringe, test tube etc..
Test method
After the adaptabilities of 3 days are raised, it is divided into 4 groups (male and female half and half) at random, often organizes each 20;Matched group, 3 differences
Medicine group (respectively 200g/kg body weight, 160g/kg body weight, 120g/kg body weight), matched group gavage normal saline, 3 medicines
The drug powder 1 of the group gavage embodiment of the present invention 1 preparation, is dissolved in water Chinese medicine feed additive and gavages mice.
Testing index and method
(1) clinicing symptom observation: every day viewing test Mus the mental status, diet situation, the dead feelings of every day entry morbidity
Condition.
(2) pathological observation: dead Mus is carried out cuing open inspection and observes internal organs change.
(3) growth indexes is observed: test Mus is carried out routine weighing;Off-test, slaughter Mus weigh in, internal organs weight the dirtiest
Device assessment of indices: cut open inspection rat, core dirty, spleen, liver, kidney, testis, ovary, weigh, calculates internal organs according to the following formula and refers to
Number: organ index=internal organs weight/body weight × 100.
(4) liver function change is observed: after off-test, slaughter Mus, takes blood separation serum, measures AST, ALT.
Data process: data above uses SPSS 11.0 to be analyzed statistics.
Clinicing symptom observation
Matched group and test group Mus, the mental status and diet desire, to external world respond have no obvious exception.Respectively organize Mus
Morbidity and death condition such as table 1 below.
Table 1
Packet |
Sum |
Dead (only) |
Mortality rate (%) |
1(200g/kg) |
20 |
0 |
0 |
2(160g/kg) |
20 |
0 |
0 |
3(120g/kg) |
20 |
0 |
0 |
Matched group |
20 |
0 |
0 |
Pathological observation: matched group and test group, Mus carries out cuing open inspection and observes and have no that observation internal organs are obvious after slaughtering
Pathological change.
Growth indexes is observed: off-test, slaughters that Mus weighs in, internal organs weight analysis is shown in Table 2.
Table 2
Packet |
Liver index |
Cardiac index |
Renal index |
Lungs index |
Index and spleen index |
1(200g/kg) |
5.61±0.10 |
0.75±0.03 |
1.32±0.16 |
0.71±0.11 |
0.55±0.06 |
2(160g/kg) |
5.53±0.13 |
0.76±0.07 |
1.27±0.12 |
0.69±0.05 |
0.52±0.05 |
3(120g/kg) |
5.62±0.11 |
0.75±0.03 |
1.31±0.09 |
0.70±0.09 |
0.55±0.04 |
Matched group |
5.81±0.31 |
0.73±0.05 |
1.29±0.13 |
0.72±0.09 |
0.52±0.05 |
Liver function change is observed
After off-test, slaughter Mus, take blood separation serum, measure AST (glutamic oxaloacetic transaminase, GOT), ALT (third turn of ammonia of paddy
Enzyme) it is shown in Table 3.Result shows that each group of data difference compared with normal healthy controls group is not notable, all in normal range.
Table 3
Packet |
Sum |
ALT |
AST |
1(200g/kg) |
20 |
35.03±2.51 |
129.39±11.19 |
2(160g/kg) |
20 |
36.53±2.53 |
133.05±10.30 |
3(120g/kg) |
20 |
35.76±1.99 |
131.73±11.09 |
Matched group |
20 |
36.93±4.12 |
132.76±13.27 |
Long term toxicity test data
Chinese medicine feed additive 10g/kg, 20g/kg, 100g/kg of the present invention according to embodiment 1 preparation are continuous to rat
Gastric infusion 3 months, the fur of animal, the colour of skin, ingest, activity, the routine blood test of animal the most without exception, the Liver and kidney function such as urine, feces
Deng the main organs index of blood parameters and animal all in normal range, and normal kinetic zero difference histopathologic examination
Showing, the important organ such as the heart, liver, spleen, lung, kidney, adrenal gland, trachea, testis, ovary is without pathological change.Drug withdrawal checked after two weeks
Above indices all reacts without overt toxicity, shows without cumulative toxicity.
Embodiment 5 feedstuff 1
Drug powder 1 prepared by 1kg embodiment 1, Semen Maydis 50kg, rice chaff 20kg, bean cake 15kg, Testa Tritici 10kg, fish flour
3kg, bone meal 2kg, Sal 1kg send in blender, at normal temperatures stirring 1 hour, it is thus achieved that feedstuff 1.
Comparative example 1 feedstuff 2
By Semen Maydis 50kg, rice chaff 20kg, bean cake 15kg, Testa Tritici 10kg, fish flour 3kg, bone meal 2kg, Sal 1kg, 50g sulfanilamide
Dimethyl pyrimidine is sent in blender, at normal temperatures stirring 1 hour, it is thus achieved that feedstuff 2.
Comparative example 2 feedstuff 3
Semen Maydis 50kg, rice chaff 20kg, bean cake 15kg, Testa Tritici 10kg, fish flour 3kg, bone meal 2kg, Sal 1kg are sent into stirring
In machine, stirring 1 hour at normal temperatures, it is thus achieved that feedstuff 3.
Embodiment 6 prophylactic tria
EXPERIMENTAL DESIGN and packet
Experimental rabbits is randomly divided into 4 groups, often group 30, the raising of 2, every cage, and numbers.First group is blank group,
The feedstuff 3 of feeding comparative example 2 preparation, second group to the 4th group is to infect mixing coccidian oocyst, second group of feeding embodiment 5 respectively
The feedstuff 1 of preparation, the feedstuff 2 of the 3rd group of feeding comparative example 1 preparation, the feedstuff 3 of the 4th group of feeding comparative example 2 preparation, during test
Between be 28 days.
Egg capsule is inoculated
Every oral vaccination of infected group rabbit 1 × 105Individual mixing coccidian oocyst, is raised by design feeding above for the most each group
Material.
Test index
Clinical health and analyse observation
The mental status of observational record every day experimental rabbit, appetite, feces situation and feed consumption rate.In test dead if any rabbit
Die, then anatomic observation pathological change in time, slaughter rabbit after off-test and observe pathological changes.
Weigh
Testing the 0th, 7,14,21 and 28 days respectively by only weighing.
Feed conversion rate
Computing formula is: feed conversion rate=day feed consumption/Average weight increasing a day
Coccidian oocyst discharges statistics
Test the 0th, 7,14,21 and 28 days collect every rabbit feces, with Mai Kemasiteshi method (McMaster ' s
Method) the worm's ovum number (e.p.g) in its every gram feces is calculated.When egg capsule density is the biggest, count after stepwise dilution.
Effect of drugs judges
By clinical observation and analyse observation, with egg sac number, daily gain as index, medicine group and matched group are carried out t inspection
Test, and judge effect of drugs.
Three infected group daily begin with, the 5th, the phenomenon that having loose bowels occur in 6 rabbits, and whole rabbit appetite decline, and search for food
Amount reduces, dead 3 of the 4th group of appearance on the 7th, takes feces and gallbladder plate coating checking, it is seen that many coccidian oocysts, the 14th extremely
28th, occurring that groupment is searched for food decline, spirit is depressed, all has phenomenon of having loose bowels to occur, to off-test dead 18 altogether.Second
To the 7th day, group occurred that 2 rabbits have loose bowels, 10 rabbits occur that appetite declines, and feed intake reduces, and 1 rabbit occurred to the 14th day
Death, takes feces and gallbladder plate coating checking, it is seen that many coccidian oocysts, the 14th day to the 28th day, occurs that groupment is searched for food decline,
Spirit is depressed, all has phenomenon of having loose bowels to occur, to off-test dead 3 altogether.On 5th, 3rd group occurs that 3 rabbits have loose bowels, 12
Rabbit occurs that appetite declines, and feed intake reduces, and 3 rabbit death occurred to the 14th day, takes feces and gallbladder plate coating checking, can
Seeing many coccidian oocysts, the 14th day to the 28th day, occur that groupment is searched for food declines, spirit is depressed, all has phenomenon generation of having loose bowels, extremely
Off-test dead 6 altogether.Total result is shown in Table 1.
Table 1 is fallen ill death condition
Group |
Test number |
Sickness rate |
Mortality rate |
First group |
30 |
0 |
0 |
Second group |
30 |
100% (30/30) |
10.0% (3/30) |
3rd group |
30 |
100% (30/30) |
20.0% (6/30) |
4th group |
30 |
100% (30/30) |
60.0% (18/30) |
Anticoccidial effect, the results are shown in Table 2.
Table 2 coccidian oocyst discharges situation of change (egg sac number e.p.g × 105/ g feces)
Group |
0 day |
7 days |
14 days |
21 days |
28 days |
First group |
Do not detect |
Do not detect |
Do not detect |
Do not detect |
Do not detect |
Second group |
0.79±0.07 |
7.51±0.36 |
Do not detect |
Do not detect |
Do not detect |
3rd group |
0.82±0.09 |
11.03±0.51 |
8.33±0.39 |
1.39±0.03 |
Do not detect |
4th group |
0.86±0.11 |
17.53±1.51 |
47.70±2.51 |
36.83±2.09 |
29.61±2.72 |
During test, carrying out 5 feces Coccidians, the worm egg sac number result of table 2 shows, uses the medicine that the present invention provides
Thing powder, the 7th day numerical value relatively blank group of worm egg sac number dramatically increases, and reduces the most rapidly, illustrates to use the present invention to provide
Drug powder treatment rabbit coccidiosis effect preferable, use sulfanilamide two pyridine group within the 7th day, detecting when, worm egg sac number is more empty
White matched group dramatically increases, and the most drastically declines, and treatment rabbit coccidiosis effect is preferable, but the drug powder that the relatively present invention provides
Also have a certain distance, do not use the infected group worm's ovum capsule digital display of any medicine to write and rise.
Daily gain situation, the results are shown in Table 3.
Table 3 daily gain situation compares g
Group |
Average starting weight |
Average end weight |
Averagely day increment |
First group |
979.53±39.61 |
1369.11±59.93 |
13.9±2.6 |
Second group |
981.13±41.23 |
1965.53±63.39 |
35.1±3.9 |
3rd group |
983.39±36.15 |
1779.25±50.01 |
28.4±3.1 |
4th group |
989.13±32.59 |
1403.36±41.17 |
14.7±2.9 |
All above-mentioned primary these intellectual properties of enforcement, do not set this new product of enforcement limiting other forms
And/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar execution feelings
Condition.But, all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, appoints
What those skilled in the art changed possibly also with the technology contents of the disclosure above or be modified as equivalent variations etc.
Effect embodiment.But every without departing from technical solution of the present invention content, the technical spirit of the foundation present invention is to above example institute
Any simple modification, equivalent variations and the remodeling made, still falls within the protection domain of technical solution of the present invention.