CN106036132A - Feed additive capable of preventing and treating coccidiosis of minks and preparation method of feed additive - Google Patents
Feed additive capable of preventing and treating coccidiosis of minks and preparation method of feed additive Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention discloses a feed additive capable of preventing and treating coccidiosis of minks and a preparation method of the feed additive. The feed additive is prepared from the following components of enteromorpha, black sesame seeds, Arctic shrimps, rice bran, silkworm chrysalis, fish scales, olive oil, egg yolk, fructus ulmi macrocarpae, grand torreya seeds, pumpkin seeds, semen myristicae, smoked plums, fructus litseae, abutilon peniculatum, fruits or seeds of apple of peru, herba artemisiae scopariae, herb of sibirica walking fern, white peony roots, downy rosemyrtle root, wood of largeleaf dogwood, ginseng, common selfheal fruit-spike and radix polygoni multiflori. Based on the effect of brightening hair color, the feed additive disclosed by the invention also has a good treatment effect on the coccidiosis, can enhance the immunity of organisms, and facilitates increase of economic benefits of breeding households.
Description
Technical field
The present invention relates to a kind of feed additive, be specifically related to a kind of feed additive preventing and treating mink coccidiosis, this
The bright preparation method further relating to this feed additive.
Background technology
Standard mink skin is the fur coat of a kind of preciousness, and kind color is varied, expensive, has the laudatory title of " king of fur coat ".
In terms of the quality and value of standard mink skin, its utilization rate is also above the big capillary skin such as Vulpes, raccoon fur, and especially domestic market potentiality are very
Greatly.Standard mink skin is the shortest with its lint, bright luxurious and famous, is the most former of making clothes, collar, medicated cap, cuff and decorations mouth
Material skin, utilizes face relatively wide, and demand is the biggest.And the big capillary skin such as Vulpes, raccoon fur, owing to lint relatively standard mink skin is the longest, not as good as mink
Skin is magnificent, and domestic market is not suitable for overcoat processed, and is only suitable for making the ornaments such as collar, cuff, tippet, therefore utilization rate relatively standard mink skin
Low.As can be seen here, the development prospect of the little capillary skin animal based on mink is better than the big capillary skin animal such as Vulpes, Nyctereutes procyonoides.Development
The economic worth that mink produces, outside defeathering skin, other by-product values are the most considerable.Mink meat is delicious and tasty, nutritious,
High containing protein, heat is big.According to surveying and determination, containing dry 38.4% in mink meat, wherein protein 18%, fat 12%.Often
100g meat heat content is 3320J, and current mink meat becomes a kind of game delicacies with flavour.
Coccidiosis is a kind of infectious disease that hazard ratio is more serious, the cattle and sheep pig dog in domestic animal and the chicken and duck goose in poultry and
Wild animal has parasitism.It destroys alimentary canal mucous membrane, causes digestive tract hemorrhage, also can be destroyed because of alimentary canal mucous membrane, various
Antibacterial and various toxin cause various inflammation in invading body tissue, increase the weight of the state of an illness, cause tremendous economic to lose.Institute's has age
Mink the most susceptible to coccidiosis, but children ermine in age infects the most serious, and mortality rate is high；Mink morbidity of growing up is slight or becomes recessiveness sense
Dye.The route of infection of primary disease are by food and drinking-water.Female ermine that grows up mostly is carrier, becomes the main infection propagating primary disease
Source, young ermine is infected by the egg capsule be infected with on wedging breast during suckling；Children ermine is mainly infected by food or drinking-water；Separately
Outward, poultry raiser, instrument, mouse, fly are the most mechanically carried coccidian oocyst and propagate coccidiosis；Malnutrition, ermine house health
The condition feedstuff that caused of difference and drinking-water are polluted by coccidian oocyst to be easily caused generation and the propagation of primary disease.
At present, treatment coccidiosis is most commonly used that various antibacterials and anticoccidial specially control medicine, such as oxytetracycline, sulfonamides
Medicine, Salinomycin, nicarbazine, diclazuril etc., due to being repeatedly used for a long of these medicines, cause this pathogenic microorganism pair
Medicine creates drug resistance, reduces curative effect, and drug residue is in animal body, and its meat does not reaches nuisanceless requirement, impact
The health of people.
Summary of the invention
It is an object of the invention to provide a kind of feed additive preventing and treating mink coccidiosis and preparation method thereof, the present invention's
Feed additive, on the basis of highlighting hair color, also has good therapeutic effect, energy enhancing human body immunity power, has coccidiosis
It is beneficial to improve the economic benefit of raiser.
To achieve these goals, present invention provide the technical scheme that
A kind of feed additive preventing and treating mink coccidiosis, is made up of each component of following parts by weight: Entermorpha 20-40
Part, Semen Sesami Nigrum 5-15 part, arctic shrimp 20-40 part, Testa oryzae 6-14 part, Pupa bombycis 10-20 part, fish scale 8-16 part, olive oil 5-10 part,
Egg yolk 4-8 part, Fructus Ulmus preparatium 5-15 part, Semen Torreyae 6-14 part, Semen Cucurbitae 8-18 part, Semen Myristicae 5-15 part, Fructus Mume 4-10 part, Fructus Litseae
3-7 part, bar bar flower 5-9 part, Herba Nicandrae Physaloidis 6-12 part, Herba Artemisiae Scopariae 6-10 part, Herba Camptosori Sibirici 4-10 part, Radix Paeoniae Alba 5-15 part, Radix Rhodomyrti 8-16
Part, Lignum corni macrophyllae 4-8 part, Radix Ginseng 5-10 part, Spica Prunellae 4-8 part, Radix Polygoni Multiflori 6-10 part.
Further, a kind of feed additive preventing and treating mink coccidiosis, it is made up of each component of following parts by weight: waterside
Tongue 20 parts, Semen Sesami Nigrum 5 parts, arctic shrimp 20 parts, 6 parts of Testa oryzae, Pupa bombycis 10 parts, 8 parts of fish scale, 5 parts of olive oil, egg yolk 4 parts, Fructus Ulmus preparatium
5 parts, Semen Torreyae 6 parts, Semen Cucurbitae 8 parts, Semen Myristicae 5 parts, Fructus Mume 4 parts, Fructus Litseae 3 parts, bar bar spend 5 parts, Herba Nicandrae Physaloidis 6 parts, Herba Artemisiae Scopariae 6
Part, Herba Camptosori Sibirici 4 parts, the Radix Paeoniae Alba 5 parts, Radix Rhodomyrti 8 parts, Lignum corni macrophyllae 4 parts, Radix Ginseng 5 parts, Spica Prunellae 4 parts, Radix Polygoni Multiflori 6 parts.
Further, a kind of feed additive preventing and treating mink coccidiosis, it is made up of each component of following parts by weight: waterside
Tongue 40 parts, Semen Sesami Nigrum 15 parts, arctic shrimp 40 parts, 14 parts of Testa oryzae, Pupa bombycis 20 parts, 16 parts of fish scale, 10 parts of olive oil, egg yolk 8 parts,
Fructus Ulmus preparatium 15 parts, Semen Torreyae 14 parts, Semen Cucurbitae 18 parts, Semen Myristicae 15 parts, Fructus Mume 10 parts, Fructus Litseae 7 parts, bar bar spend 9 parts, Herba Nicandrae Physaloidis 12
Part, Herba Artemisiae Scopariae 10 parts, Herba Camptosori Sibirici 10 parts, the Radix Paeoniae Alba 15 parts, Radix Rhodomyrti 16 parts, Lignum corni macrophyllae 8 parts, Radix Ginseng 10 parts, Spica Prunellae 8 parts, He Shou
Crow 10 parts.
Further, a kind of feed additive preventing and treating mink coccidiosis, it is made up of each component of following parts by weight: waterside
Tongue 30 parts, Semen Sesami Nigrum 10 parts, arctic shrimp 30 parts, 10 parts of Testa oryzae, Pupa bombycis 15 parts, 12 parts of fish scale, 8 parts of olive oil, egg yolk 6 parts,
Fructus Ulmus preparatium 10 parts, Semen Torreyae 10 parts, Semen Cucurbitae 13 parts, Semen Myristicae 10 parts, Fructus Mume 7 parts, Fructus Litseae 5 parts, bar bar spend 7 parts, Herba Nicandrae Physaloidis 9
Part, Herba Artemisiae Scopariae 8 parts, Herba Camptosori Sibirici 7 parts, the Radix Paeoniae Alba 10 parts, Radix Rhodomyrti 12 parts, Lignum corni macrophyllae 6 parts, Radix Ginseng 8 parts, Spica Prunellae 6 parts, Radix Polygoni Multiflori 8
Part.
Mink under artificial breeding, coccidiosis sickness rate is the lowest, but in recent years along with side-product application such as a large amount of fowl internal organs
In aquaculture, the sickness rate of coccidiosis is more and more higher.After mink suffers from coccidiosis, inappetence, lassitude, unglazed by hair
Pool, eye nose has secretions, feces to start as yellow fluffy, and coccidiosis destroys intestinal mucosa, makes intestinal epithelial cell disintegrate, causes
Intestinal tube inflammation, dyspepsia, nutrient substance can not absorb, and the change of intestinal wall inflammatory and angiorrhexis, a large amount of body fluid, blood flow into intestinal
In pipe, causing disease ermine anemia, dysentery and become thin, the epithelial cell of disintegrate becomes noxious substance, can not discharge rapidly in intestinal,
Making body generation self poisoning, the later stage discharges the cerise hemafecia of band mucus, and mink becomes thin, retarded growth, even the later stage
Dead.So for this disease, present invention applicant have studied a kind of feed additive, by parasite killing anthelmintic, the solid intestinal of antidiarrheal, clear
Thermal detoxification, anti-inflammation, nourishing blood to suppress the hyperactive liver, the method built up resistance are to treat coccidiosis.
In the formula of the present invention, each low raw-material cost, it is readily available；Fructus Ulmus preparatium killing insect and eliminating accumulation, Semen Torreyae killing insect and eliminating accumulation, moisturize
Relieving constipation, Semen Cucurbitae anthelmintic, Semen Myristicae warming middle-JIAO to promote flow of QI, relieving diarrhea with astringents, Fructus Mume astringes the lung, astringing intestine to stop diarrhea, promotes the production of body fluid, relieving colic caused by ascaris, and Fructus Litseae warming middle-JIAO dissipates
Cold, promoting the circulation of QI to relieve pain, are principal agent altogether, Semen Cucurbitae compatibility Fructus Ulmus preparatium, Semen Torreyae, the effect of enhancing parasite killing anthelmintic, then coordinate Semen Myristicae, crow
Prunus mume (sieb.) sieb.et zucc., Fructus Litseae warming spleen and stomach for dispelling cold, antidiarrheal thickness intestinal, set about from taking stopgap measures, first remove or kill internal coccidiosis, and the solid intestinal of antidiarrheal, from root
First eliminate pathogen in basis, make mink no longer dysentery；Ba Ba flower heat-clearing and toxic substances removing, Herba Nicandrae Physaloidis heat-clearing and toxic substances removing, diuresis, calm, Herba Artemisiae Scopariae
Eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice, Herba Camptosori Sibirici stops blooding, antiinflammatory, Radix Paeoniae Alba nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, suppressing liver-YANG, mountain
Harvesting root regulating QI to relieve pain, dampness removing antidiarrheal, kidney tonifying nourishes blood, Lignum corni macrophyllae nourishing blood and preventing abortion, promoting blood circulation and stopping pain, ginseng qi-tonifying, Gu de-, promote the production of body fluid, peace
God, Fructus Alpiniae Oxyphyllae, Spica Prunellae purging liver-fire, improving eyesight, mass dissipating and swelling eliminating, Radix Polygoni Multiflori nourishing the blood and yin, loosening bowel to relieve constipation, preventing the attack (or recurrence) of malaria, dispel the wind, removing toxic substances,
Heat-clearing and toxic substances removing, anti-inflammation eliminate the intestinal tube inflammation because coccidiosis causes, body self poisoning phenomenon, nourishing blood to suppress the hyperactive liver rapid healing
Enteritis, QI invigorating, YIN nourishing, with enhancing human body immunity power and premunition, are accessory drugs altogether.The most each material combination is played parasite killing anthelmintic altogether, is stopped
Rush down solid intestinal, heat-clearing and toxic substances removing, anti-inflammation, nourishing blood to suppress the hyperactive liver, the merit built up resistance, rapid healing mink coccidiosis.Additionally, raw material
In be also added with the nutritional labelings such as Entermorpha, Semen Sesami Nigrum, arctic shrimp, Testa oryzae, Pupa bombycis, fish scale, olive oil, egg yolk, Entermorpha contains
Carbohydrate containing, protein, crude fibre, aminoacid, fatty acid, vitamin and several mineral materials, wherein iron content is in China
Be recited as on food nourishment composition table China's food, Semen Sesami Nigrum sweet in the mouth, property puts down, and has a nourishing the liver and kidney, benefit blood intestine moistening, relieving constipation,
The function of lactogenesis, moreover it is possible to black hair hair care, arctic shrimp is nutritious, containing the unsaturated fatty acid of a large amount of high-qualitys, also rich in tieing up him
The elements such as life B12, zinc, iodine, phosphorus, potassium, selenium, ferrum element and the calcium of trace, magnesium and sodium, Testa oryzae strengthening the spleen and stomach, swelling diuretic, and contain
Having some unsaturated fatty acids, Pupa bombycis can help digestion and regulate the flow of vital energy, and improves feedstuff mouthfeel, promotes mink feed, and fish scale contains abundant egg
White matter, fat and multivitamin, olive oil can improve mink digestive system function, beneficially mink and digest and assimilate, also have and lure
Food effect, egg yolk has the effect of YIN nourishing, mind tranquilizing and the heart calming.The present invention at parasite killing anthelmintic, the solid intestinal of antidiarrheal, heat-clearing and toxic substances removing, antibacterial disappear
Treat coccidiosis under the effect of scorching, nourishing blood to suppress the hyperactive liver, strengthen the resistance of mink body, moreover it is possible to promote mink feed, highlight simultaneously
Because of the sick and hair color of dimness.
Due to the reason such as Global climate change, body eutrophication, the ocean green tide of tangleweed Entermorpha is caused to break out, in a large number
Entermorpha is floating gathers bank, blocks the fairway, and destroys marine ecosystems simultaneously, serious threat inshore fishing, tourism development,
But containing carbohydrate containing, protein, crude fibre, aminoacid, fatty acid, vitamin and several mineral materials in Entermorpha, its
Middle iron content be recited as on Chinese food nutrient component meter China's food, Appropriate application of the present invention Entermorpha, not only solve
The ecological nuclear sterile barley that Entermorpha raised growth of having determined brings, but also provide more rich nutrition for mink, improve mink
Appetite.
The present invention also provides for the preparation method of a kind of feed additive preventing and treating mink coccidiosis, and described preparation method includes
Following steps:
(1) taking cutability Fructus Amomi Rotundus, add wheat bran, at 155 ± 5 DEG C, bran simmers 15min, every 100kg Semen Myristicae, uses wheat bran 40kg,
Frying to wheat bran is coke yellow, and Semen Myristicae is sepia, and the face of wrapping up in is taken out when having crack, and sieve removes wheat bran, cools, standby；
(2) by after Semen Cucurbitae parching to brown, with Fructus Ulmus preparatium, Semen Torreyae, Fructus Mume, Fructus Litseae, Ba Bahua, Herba Nicandrae Physaloidis, Herba Artemisiae Scopariae, Herba Camptosori Sibirici,
The Radix Paeoniae Alba, Radix Rhodomyrti, Lignum corni macrophyllae, Radix Ginseng, Spica Prunellae, Radix Polygoni Multiflori and step (1) process after Semen Myristicae mixing after grind to
80 mesh, gross weight is designated as 1 part, adds 3 parts of sterilized water, 1 part of ethanol, soaks 1h, then by said medicine and liquid at 50 ± 5 DEG C
Being collectively disposed in microwave extracting tank and extract, control microwave frequency is 1000MHz, and microwave power is 120W/L, carries out microwave
Radiation, then steps up the operating pressure in extractor in 5-10min to 0.2MPa, and microwave irradiation time amounts to
30min, obtains extract；
(3) after the extract of step (2) being decompressed, filter, reclaim ethanol, collect filtrate, carry out being concentrated into phase by filtrate
It is 1.2 ± 0.05 to density, obtains traditional Chinese drug inspissation cream；
(4) by Entermorpha, fish scale clean dry, then Entermorpha, fish scale are ground with Semen Sesami Nigrum, arctic shrimp, Pupa bombycis, with
The traditional Chinese drug inspissation cream mixing that Testa oryzae, egg yolk, olive oil, step (3) prepare, stirs, and sterilizing obtains described feedstuff and adds
Add agent.
Store method: cryopreservation at-7-2 DEG C.
Using method: after the feed additive of the present invention is heated to room temperature, with normal feedstuff with 1:(10-20) ratio
Throw something and feed after mix homogeneously, one day three times.
In the preparation method of the present invention, its toxicity can be reduced by after Semen Myristicae parched with bran, strengthen its anti-diarrhea effect；By medicine powder
At 50 ± 5 DEG C, soak 1h with without the mixed liquor of sterilized water and ethanol after broken, can make sterilized water and ethanol molecule well into
The cell interior that cell wall is broken, fully infiltrates medical material so that medical material when microwave extracting, microwave heating make solvent sterilized water,
Ethanol absorbs microwave energy and produces substantial amounts of thermal energy, makes intracellular temperature increase rapidly, the pressure of generation further by cell membrane and
Cell wall breaks through, and forms some small holes, until crackle occurs in cell surface, makes solvent enter more fully intracellular
Portion, microwave can also promote that the molecule in solvent quickly rotates and moves, especially water, these polar molecules of ethanol can be micro-
Under ripple effect, generation moment intensifies, and produces the vibration of key, tear and interparticle friction and collision, and is quickly generated big calorimetric
Can, strong in cell interior penetration power, promote cell to continue to rupture, make the effective ingredient in Cell sap and medicine quickly overflow and expand
It is dissipated in solvent, substantially reduces the extraction time of effective ingredient, drastically increase extraction efficiency, and microwave heating is equal
Even, belong to intraor extracellular and heat simultaneously, it is to avoid thermograde during traditional extraction heating, medical material heated time is short, is conducive to
The extraction of effective ingredient in medical material.Additionally microwave extracting can extract the effective ingredient in medical material, simultaneously solvent load in high volume
Less than traditional handicraft, facilitate in subsequent step and extract is concentrated purification, time-consuming；Extract is spray-dried and superfine powder
Again dissolve after broken, the impurity in Chinese medicine extract after fine straining, can be eliminated to greatest extent.
Beneficial effects of the present invention:
(1) for mink coccidiosis, present invention applicant have studied a kind of feed additive, by medicine food with the method mended
Treat coccidiosis.In the formula of the present invention, each low raw-material cost, it is readily available；Fructus Ulmus preparatium killing insect and eliminating accumulation, Semen Torreyae parasite killing disappears
Amassing, moistening dryness for relaxing bowels, Semen Cucurbitae anthelmintic, Semen Myristicae warming middle-JIAO to promote flow of QI, relieving diarrhea with astringents, Fructus Mume is astringed the lung, and astringing intestine to stop diarrhea promotes the production of body fluid, relieving colic caused by ascaris, Fructus Litseae
Warming spleen and stomach for dispelling cold, promoting the circulation of QI to relieve pain, are principal agent altogether, Semen Cucurbitae compatibility Fructus Ulmus preparatium, Semen Torreyae, the effect of enhancing parasite killing anthelmintic, then coordinate lima bean
Cool, Fructus Mume, Fructus Litseae warming spleen and stomach for dispelling cold, antidiarrheal thickness intestinal, set about from taking stopgap measures, first remove or kill internal coccidiosis, the solid intestinal of antidiarrheal,
The most first eliminate pathogen, make mink no longer dysentery；Ba Ba flower heat-clearing and toxic substances removing, Herba Nicandrae Physaloidis heat-clearing and toxic substances removing, diuresis, calm,
Herba Artemisiae Scopariae eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice, Herba Camptosori Sibirici stops blooding, antiinflammatory, Radix Paeoniae Alba nourishing blood for regulating menstruation, astringing YIN to stop sweating, and liver stabilized by easing the affected liver to relieve pain
Sun, Radix Rhodomyrti regulating QI to relieve pain, dampness removing antidiarrheal, kidney tonifying nourishes blood, Lignum corni macrophyllae nourishing blood and preventing abortion, promoting blood circulation and stopping pain, ginseng qi-tonifying, Gu de-, raw
Tianjin, calms the nerves, Fructus Alpiniae Oxyphyllae, Spica Prunellae purging liver-fire, improving eyesight, mass dissipating and swelling eliminating, Radix Polygoni Multiflori nourishing the blood and yin, loosening bowel to relieve constipation, and preventing the attack (or recurrence) of malaria dispels the wind,
Detoxifying, heat-clearing and toxic substances removing, anti-inflammation eliminate the intestinal tube inflammation because coccidiosis causes, body self poisoning phenomenon, and nourishing blood to suppress the hyperactive liver is fast
Speed cures enteritis, and QI invigorating, YIN nourishing, with enhancing human body immunity power and premunition, are accessory drugs altogether.The most each material combination plays parasite killing altogether
Anthelmintic, the solid intestinal of antidiarrheal, heat-clearing and toxic substances removing, anti-inflammation, nourishing blood to suppress the hyperactive liver, the merit built up resistance, rapid healing mink coccidiosis.This
Outward, raw material has been also added with the nutritional labelings such as Entermorpha, Semen Sesami Nigrum, arctic shrimp, Testa oryzae, Pupa bombycis, fish scale, olive oil, egg yolk, waterside
Tongue contains carbohydrate containing, protein, crude fibre, aminoacid, fatty acid, vitamin and several mineral materials, wherein iron content
Chinese food nutrient component meter is recited as China's food, Semen Sesami Nigrum sweet in the mouth, property puts down, and has a nourishing the liver and kidney, benefit blood intestine moistening,
Relieving constipation, the function of lactogenesis, moreover it is possible to black hair hair care, arctic shrimp is nutritious, containing the unsaturated fatty acid of a large amount of high-qualitys, also rich in
The elements such as the calcium of Vitamin B12, zinc, iodine, phosphorus, potassium, selenium, ferrum element and trace, magnesium and sodium, Testa oryzae strengthening the spleen and stomach, swelling diuretic,
And containing some unsaturated fatty acids, Pupa bombycis can help digestion and regulate the flow of vital energy, improving feedstuff mouthfeel, promote mink feed, fish scale contains abundant
Protein, fat and multivitamin, olive oil can improve mink digestive system function, beneficially mink and digest and assimilate, also have
Having food calling effect, egg yolk has the effect of YIN nourishing, mind tranquilizing and the heart calming.The present invention consolidates intestinal, heat-clearing and toxic substances removing in parasite killing anthelmintic, antidiarrheal, resists
Bacterium antiinflammatory, nourishing blood to suppress the hyperactive liver effect under treat coccidiosis, simultaneously strengthen mink body resistance, moreover it is possible to promote mink feed,
Highlight because of the sick and hair color of dimness.
(2) due to the reason such as Global climate change, body eutrophication, the ocean green tide of tangleweed Entermorpha is caused to break out,
Entermorpha is floating in a large number gathers bank, blocks the fairway, destroys marine ecosystems, serious threat inshore fishing, tourist industry simultaneously
Development, but containing carbohydrate containing, protein, crude fibre, aminoacid, fatty acid, vitamin and multi mineral in Entermorpha
Matter, wherein iron content be recited as on Chinese food nutrient component meter China's food, Appropriate application of the present invention Entermorpha, no
Address only the ecological nuclear sterile barley that Entermorpha raised growth brings, but also provide more rich nutrition for mink, improve
The appetite of mink.
(3) each component of the feed additive of the preventing and treating mink coccidiosis of the present invention is environmental protection raw material, to mink
Nontoxic, do not contain chemical drugs or antibiotic, and effective ingredient is extracted into extraction cream incorporation feedstuff and adds by the present invention
Adding in agent, medicine can be absorbed by organisms rapidly, fast onset effect, good to the therapeutic effect of the mink suffering from coccidiosis, promotes
The fast quick-recovery of mink, shortens and recovers convalescent period, strengthens the immunity of mink, improves mink appetite, highlights mink hair color, is conducive to
Improve the economic benefit of raiser.
(4), in the preparation method of the present invention, its toxicity can be reduced by after Semen Myristicae parched with bran, strengthen its anti-diarrhea effect；By medicine
Thing soaks 1h with the mixed liquor without sterilized water and ethanol after pulverizing at 50 ± 5 DEG C, and sterilized water and ethanol molecule can be made abundant
Enter the cell interior that cell wall is broken, fully infiltrate medical material so that medical material is when microwave extracting, and microwave heating makes solvent aseptic
Water, toluene and ethanol absorb microwave energy and produce substantial amounts of thermal energy, make intracellular temperature increase rapidly, and the pressure of generation further will
Cell membrane and cell wall break through, and form some small holes, until crackle occurs in cell surface, make solvent enter more fully
Cell interior, microwave can also promote that the molecule in solvent quickly rotates and moves, especially water, these polar molecules of ethanol can
Intensify with generation moment under microwave action, produce the vibration of key, tear and interparticle friction and collision, and be quickly generated big
Calorimetric energy, strong in cell interior penetration power, promote cell to continue to rupture, make the effective ingredient in Cell sap and medicine quickly overflow
And diffuse in solvent, substantially reduce the extraction time of effective ingredient, drastically increase extraction efficiency, and microwave adds
Heat uniformly, belongs to intraor extracellular and heats simultaneously, it is to avoid thermograde during traditional extraction heating, medical material heated time is short, has
It is beneficial to the extraction of effective ingredient in medical material.Additionally microwave extracting can extract the effective ingredient in medical material, simultaneously solvent in high volume
Consumption is less than traditional handicraft, facilitates in subsequent step and extract is concentrated purification, time-consuming；Extract is spray-dried and surpasses
Again dissolve after Crushing of Ultrafine, the impurity in Chinese medicine extract after fine straining, can be eliminated to greatest extent.
Detailed description of the invention
Below in conjunction with embodiments of the invention, technical scheme is clearly and completely described.
Embodiment 1
A kind of feed additive preventing and treating mink coccidiosis, is made up of each component of following parts by weight: Entermorpha 20 parts, black
Semen Sesami 5 parts, arctic shrimp 20 parts, 6 parts of Testa oryzae, Pupa bombycis 10 parts, 8 parts of fish scale, 5 parts of olive oil, egg yolk 4 parts, Fructus Ulmus preparatium 5 parts, Semen Torreyae 6
Part, Semen Cucurbitae 8 parts, Semen Myristicae 5 parts, Fructus Mume 4 parts, Fructus Litseae 3 parts, bar bar spend 5 parts, Herba Nicandrae Physaloidis 6 parts, Herba Artemisiae Scopariae 6 parts, Herba Camptosori Sibirici 4
Part, the Radix Paeoniae Alba 5 parts, Radix Rhodomyrti 8 parts, Lignum corni macrophyllae 4 parts, Radix Ginseng 5 parts, Spica Prunellae 4 parts, Radix Polygoni Multiflori 6 parts.
The preparation method of the feed additive of described preventing and treating mink coccidiosis comprises the following steps:
(1) taking cutability Fructus Amomi Rotundus, add wheat bran, at 155 ± 5 DEG C, bran simmers 15min, every 100kg Semen Myristicae, uses wheat bran 40kg,
Frying to wheat bran is coke yellow, and Semen Myristicae is sepia, and the face of wrapping up in is taken out when having crack, and sieve removes wheat bran, cools, standby；
(2) by after Semen Cucurbitae parching to brown, with Fructus Ulmus preparatium, Semen Torreyae, Fructus Mume, Fructus Litseae, Ba Bahua, Herba Nicandrae Physaloidis, Herba Artemisiae Scopariae, Herba Camptosori Sibirici,
The Radix Paeoniae Alba, Radix Rhodomyrti, Lignum corni macrophyllae, Radix Ginseng, Spica Prunellae, Radix Polygoni Multiflori and step (1) process after Semen Myristicae mixing after grind to
80 mesh, gross weight is designated as 1 part, adds 3 parts of sterilized water, 1 part of ethanol, soaks 1h, then by said medicine and liquid at 50 ± 5 DEG C
Being collectively disposed in microwave extracting tank and extract, control microwave frequency is 1000MHz, and microwave power is 120W/L, carries out microwave
Radiation, then steps up the operating pressure in extractor in 5-10min to 0.2MPa, and microwave irradiation time amounts to
30min, obtains extract；
(3) after the extract of step (2) being decompressed, filter, reclaim ethanol, collect filtrate, carry out being concentrated into phase by filtrate
It is 1.2 ± 0.05 to density, obtains traditional Chinese drug inspissation cream；
(4) by Entermorpha, fish scale clean dry, then Entermorpha, fish scale are ground with Semen Sesami Nigrum, arctic shrimp, Pupa bombycis, with
The traditional Chinese drug inspissation cream mixing that Testa oryzae, egg yolk, olive oil, step (3) prepare, stirs, and sterilizing obtains described feedstuff and adds
Add agent.
Store method: cryopreservation at-7-2 DEG C.
Using method: after the feed additive of the present invention is heated to room temperature, with normal feedstuff with 1:(10-20) ratio
Throw something and feed after mix homogeneously, one day three times.
Embodiment 2
A kind of feed additive preventing and treating mink coccidiosis, is made up of each component of following parts by weight: Entermorpha 40 parts, black
Semen Sesami 15 parts, arctic shrimp 40 parts, 14 parts of Testa oryzae, Pupa bombycis 20 parts, 16 parts of fish scale, 10 parts of olive oil, egg yolk 8 parts, Fructus Ulmus preparatium 15 parts,
Semen Torreyae 14 parts, Semen Cucurbitae 18 parts, Semen Myristicae 15 parts, Fructus Mume 10 parts, Fructus Litseae 7 parts, bar bar spend 9 parts, Herba Nicandrae Physaloidis 12 parts, Herba Artemisiae Scopariae 10
Part, Herba Camptosori Sibirici 10 parts, the Radix Paeoniae Alba 15 parts, Radix Rhodomyrti 16 parts, Lignum corni macrophyllae 8 parts, Radix Ginseng 10 parts, Spica Prunellae 8 parts, Radix Polygoni Multiflori 10 parts.
The preparation method of the feed additive of preventing and treating mink coccidiosis, described preparation method comprises the following steps:
(1) taking cutability Fructus Amomi Rotundus, add wheat bran, at 155 ± 5 DEG C, bran simmers 15min, every 100kg Semen Myristicae, uses wheat bran 40kg,
Frying to wheat bran is coke yellow, and Semen Myristicae is sepia, and the face of wrapping up in is taken out when having crack, and sieve removes wheat bran, cools, standby；
(2) by after Semen Cucurbitae parching to brown, with Fructus Ulmus preparatium, Semen Torreyae, Fructus Mume, Fructus Litseae, Ba Bahua, Herba Nicandrae Physaloidis, Herba Artemisiae Scopariae, Herba Camptosori Sibirici,
The Radix Paeoniae Alba, Radix Rhodomyrti, Lignum corni macrophyllae, Radix Ginseng, Spica Prunellae, Radix Polygoni Multiflori and step (1) process after Semen Myristicae mixing after grind to
80 mesh, gross weight is designated as 1 part, adds 3 parts of sterilized water, 1 part of ethanol, soaks 1h, then by said medicine and liquid at 50 ± 5 DEG C
Being collectively disposed in microwave extracting tank and extract, control microwave frequency is 1000MHz, and microwave power is 120W/L, carries out microwave
Radiation, then steps up the operating pressure in extractor in 5-10min to 0.2MPa, and microwave irradiation time amounts to
30min, obtains extract；
(3) after the extract of step (2) being decompressed, filter, reclaim ethanol, collect filtrate, carry out being concentrated into phase by filtrate
It is 1.2 ± 0.05 to density, obtains traditional Chinese drug inspissation cream；
(4) by Entermorpha, fish scale clean dry, then Entermorpha, fish scale are ground with Semen Sesami Nigrum, arctic shrimp, Pupa bombycis, with
The traditional Chinese drug inspissation cream mixing that Testa oryzae, egg yolk, olive oil, step (3) prepare, stirs, and sterilizing obtains described feedstuff and adds
Add agent.
Store method: cryopreservation at-7-2 DEG C.
Using method: after the feed additive of the present invention is heated to room temperature, with normal feedstuff with 1:(10-20) ratio
Throw something and feed after mix homogeneously, one day three times.
Embodiment 3
A kind of feed additive preventing and treating mink coccidiosis, is made up of each component of following parts by weight: Entermorpha 30 parts, black
Semen Sesami 10 parts, arctic shrimp 30 parts, 10 parts of Testa oryzae, Pupa bombycis 15 parts, 12 parts of fish scale, 8 parts of olive oil, egg yolk 6 parts, Fructus Ulmus preparatium 10 parts,
Semen Torreyae 10 parts, Semen Cucurbitae 13 parts, Semen Myristicae 10 parts, Fructus Mume 7 parts, Fructus Litseae 5 parts, bar bar spend 7 parts, Herba Nicandrae Physaloidis 9 parts, Herba Artemisiae Scopariae 8 parts,
Herba Camptosori Sibirici 7 parts, the Radix Paeoniae Alba 10 parts, Radix Rhodomyrti 12 parts, Lignum corni macrophyllae 6 parts, Radix Ginseng 8 parts, Spica Prunellae 6 parts, Radix Polygoni Multiflori 8 parts.
The preparation method of the feed additive of preventing and treating mink coccidiosis, described preparation method comprises the following steps:
(1) taking cutability Fructus Amomi Rotundus, add wheat bran, at 155 ± 5 DEG C, bran simmers 15min, every 100kg Semen Myristicae, uses wheat bran 40kg,
Frying to wheat bran is coke yellow, and Semen Myristicae is sepia, and the face of wrapping up in is taken out when having crack, and sieve removes wheat bran, cools, standby；
(2) by after Semen Cucurbitae parching to brown, with Fructus Ulmus preparatium, Semen Torreyae, Fructus Mume, Fructus Litseae, Ba Bahua, Herba Nicandrae Physaloidis, Herba Artemisiae Scopariae, Herba Camptosori Sibirici,
The Radix Paeoniae Alba, Radix Rhodomyrti, Lignum corni macrophyllae, Radix Ginseng, Spica Prunellae, Radix Polygoni Multiflori and step (1) process after Semen Myristicae mixing after grind to
80 mesh, gross weight is designated as 1 part, adds 3 parts of sterilized water, 1 part of ethanol, soaks 1h, then by said medicine and liquid at 50 ± 5 DEG C
Being collectively disposed in microwave extracting tank and extract, control microwave frequency is 1000MHz, and microwave power is 120W/L, carries out microwave
Radiation, then steps up the operating pressure in extractor in 5-10min to 0.2MPa, and microwave irradiation time amounts to
30min, obtains extract；
(3) after the extract of step (2) being decompressed, filter, reclaim ethanol, collect filtrate, carry out being concentrated into phase by filtrate
It is 1.2 ± 0.05 to density, obtains traditional Chinese drug inspissation cream；
(4) by Entermorpha, fish scale clean dry, then Entermorpha, fish scale are ground with Semen Sesami Nigrum, arctic shrimp, Pupa bombycis, with
The traditional Chinese drug inspissation cream mixing that Testa oryzae, egg yolk, olive oil, step (3) prepare, stirs, and sterilizing obtains described feedstuff and adds
Add agent.
Store method: cryopreservation at-7-2 DEG C.
Using method: after the feed additive of the present invention is heated to room temperature, with normal feedstuff with 1:(10-20) ratio
Throw something and feed after mix homogeneously, one day three times.
Embodiment 4
A kind of feed additive preventing and treating mink coccidiosis, is made up of each component of following parts by weight: Entermorpha 30 parts, black
Semen Sesami 15 parts, arctic shrimp 40 parts, 6 parts of Testa oryzae, Pupa bombycis 10 parts, 8 parts of fish scale, 10 parts of olive oil, egg yolk 6 parts, Fructus Ulmus preparatium 10 parts, Chinese torreya
Son 10 parts, Semen Cucurbitae 8 parts, Semen Myristicae 10 parts, Fructus Mume 10 parts, Fructus Litseae 7 parts, bar bar spend 5 parts, Herba Nicandrae Physaloidis 6 parts, Herba Artemisiae Scopariae 8 parts, horse
Pedal grass 7 parts, the Radix Paeoniae Alba 10 parts, Radix Rhodomyrti 16 parts, Lignum corni macrophyllae 8 parts, Radix Ginseng 10 parts, Spica Prunellae 4 parts, Radix Polygoni Multiflori 10 parts.
The preparation method of the feed additive of preventing and treating mink coccidiosis, described preparation method comprises the following steps:
(1) taking cutability Fructus Amomi Rotundus, add wheat bran, at 155 ± 5 DEG C, bran simmers 15min, every 100kg Semen Myristicae, uses wheat bran 40kg,
Frying to wheat bran is coke yellow, and Semen Myristicae is sepia, and the face of wrapping up in is taken out when having crack, and sieve removes wheat bran, cools, standby；
(2) by after Semen Cucurbitae parching to brown, with Fructus Ulmus preparatium, Semen Torreyae, Fructus Mume, Fructus Litseae, Ba Bahua, Herba Nicandrae Physaloidis, Herba Artemisiae Scopariae, Herba Camptosori Sibirici,
The Radix Paeoniae Alba, Radix Rhodomyrti, Lignum corni macrophyllae, Radix Ginseng, Spica Prunellae, Radix Polygoni Multiflori and step (1) process after Semen Myristicae mixing after grind to
80 mesh, gross weight is designated as 1 part, adds 3 parts of sterilized water, 1 part of ethanol, soaks 1h, then by said medicine and liquid at 50 ± 5 DEG C
Being collectively disposed in microwave extracting tank and extract, control microwave frequency is 1000MHz, and microwave power is 120W/L, carries out microwave
Radiation, then steps up the operating pressure in extractor in 5-10min to 0.2MPa, and microwave irradiation time amounts to
30min, obtains extract；
(3) after the extract of step (2) being decompressed, filter, reclaim ethanol, collect filtrate, carry out being concentrated into phase by filtrate
It is 1.2 ± 0.05 to density, obtains traditional Chinese drug inspissation cream；
(4) by Entermorpha, fish scale clean dry, then Entermorpha, fish scale are ground with Semen Sesami Nigrum, arctic shrimp, Pupa bombycis, with
The traditional Chinese drug inspissation cream mixing that Testa oryzae, egg yolk, olive oil, step (3) prepare, stirs, and sterilizing obtains described feedstuff and adds
Add agent.
Store method: cryopreservation at-7-2 DEG C.
Using method: after the feed additive of the present invention is heated to room temperature, with normal feedstuff with 1:(10-20) ratio
Throw something and feed after mix homogeneously, one day three times.
Embodiment 5 controlling experiment
EXPERIMENTAL DESIGN and packet: select the close healthy mink of 50 body weight, health status as test mink, will test
Mink is randomly divided into 5 groups, often 10 minks of group, and test period is 24 days.Often group carries out following operation after being normally carried out feeding:
First group: for blank group, use every day normal feedstuff to carry out feeding.
Second group: infect mixing coccidian oocyst, feed additive embodiment 1 prepared and the normal feedstuff ratio with 1:20
Throw something and feed after example mix homogeneously, one day three times.
3rd group: infect mixing coccidian oocyst, feed additive embodiment 3 prepared and the normal feedstuff ratio with 1:15
Throw something and feed after example mix homogeneously, one day three times.
4th group: infect mixing coccidian oocyst, feed additive embodiment 4 prepared and the normal feedstuff ratio with 1:10
Throw something and feed after example mix homogeneously, one day three times.
5th group: infect mixing coccidian oocyst, use every day normal feedstuff to carry out feeding.
Egg capsule is inoculated: every oral vaccination of test group mink 1 × 105Individual mixing coccidian oocyst, each group is pressed above subsequently
Design is carried out.
Test index:
Clinical health and analyse observation: observational record experiment the every day mental status of mink, appetite, feces situation.
If any mink death in test, then anatomic observation pathological change in time, slaughter mink after off-test and observe pathological changes.
Coccidian oocyst discharges statistics: within the 0th, 6,12,18 and 24 days, collects every mink feces in test, uses Cecil McMaster
Family name's method (McMaster ' smethod) calculate the worm's ovum number (e.p.g) in its every gram feces.When egg capsule density is the biggest, stepwise dilution
After count.
Effect of drugs judges: by clinical observation and analyse observation, with egg sac number as index, test group is entered with matched group
Performing check, and judge effect of drugs.
Second and third, four, five groups of minks infecting coccidian oocysts all began with 2-4 and only occur that has loose bowels shows at the 6-8 days
As, whole mink appetite decline, and food ration reduces；Second and third, four groups to the 6th days time occur that 2-3 mink has loose bowels, 5,6 water
Ermine occurs that appetite declines, and feed intake reduces, and 0-2 mink death occurs, take feces and gallbladder plate coating checking during to the 17th day, can
See many coccidian oocysts；Occur dead 1 when the 5th group the 6th day, take feces and gallbladder plate coating checking, it is seen that many coccidiosis ovum
Capsule, the 12nd day to the 24th day, occurs that groupment is searched for food decline, and spirit is depressed, all has phenomenon of having loose bowels to occur, the most dead to off-test
Die 8；
Test mink morbidity death condition part table 1, anticoccidial effect experimental data is shown in Table 2.
Table 1 is fallen ill death condition
| Group | Test number/only | Morbidity number/only | Sickness rate | Death toll/only | Mortality rate |
| First group | 10 | 0 | 0 | 0 | 0 |
| Second group | 10 | 10 | 100% | 2 | 20% |
| 3rd group | 10 | 10 | 100% | 1 | 10% |
| 4th group | 10 | 10 | 100% | 0 | 0 |
| 5th group | 10 | 10 | 100% | 8 | 80% |
Table 2 coccidian oocyst discharges situation of change (e.p.g × 105/ g feces)
| Group | 0 day | 6 days | 12 days | 18 days | 24 days |
| First group | Do not detect | Do not detect | Do not detect | Do not detect | Do not detect |
| Second group | 0.78±0.08 | 4.21±0.11 | Do not detect | Do not detect | Do not detect |
| 3rd group | 0.80±0.05 | 3.98±0.15 | Do not detect | Do not detect | Do not detect |
| 4th group | 0.83±0.07 | 4.08±0.15 | Do not detect | Do not detect | Do not detect |
| 5th group | 0.79±0.07 | 6.99±0.51 | 23.59±1.95 | 60.79±2.67 | 39.86±1.54 |
From the data of table 1 it can be seen that inoculate four groups of minks of coccidian oocyst, by the feed additive of the present invention and basis
Feedstuff mixing feeding mink second and third, the mortality rate of the mink of four groups feeds significantly lower than being not added with feed additive of the present invention
The mink of the 5th group of food, mortality rate, below 20%, minimum can reach zero death rate, and the 5th group of mortality rate is up to 80%.
From the data of table 2 it can be seen that during Shi Yan, carry out 5 feces Coccidians, the subcutaneous injection present invention raises
Feed additives second and third, the mink of the coccidian oocyst quantity of the mink of four groups and five group of injectable dextrose monohydrate injection
The first six sky of coccidian oocyst quantity dramatically increases, second and third, the coccidian oocyst quantity of the mink of four groups subtracted rapidly after six days
Few, do not detected coccidian oocyst when 12 days, illustrate that the feed additive treatment coccidiosis effect of the present invention is preferable, the 5th group of mink
The quantity of coccidian oocyst sharply increase with natural law, until mink is dead.
The above is the preferred embodiment of the present invention, its object is to allow person skilled in the art understand the present invention
Content is also carried out, it is noted that for those skilled in the art, without departing from the principle of the invention
Under premise, it is also possible to make some improvements and modifications, these improvements and modifications are also considered as protection scope of the present invention.
Claims (5)
1. the feed additive preventing and treating mink coccidiosis, it is characterised in that be made up of each component of following parts by weight: waterside
Tongue 20-40 part, Semen Sesami Nigrum 5-15 part, arctic shrimp 20-40 part, Testa oryzae 6-14 part, Pupa bombycis 10-20 part, fish scale 8-16 part, olive oil
5-10 part, egg yolk 4-8 part, Fructus Ulmus preparatium 5-15 part, Semen Torreyae 6-14 part, Semen Cucurbitae 8-18 part, Semen Myristicae 5-15 part, Fructus Mume 4-10
Part, Fructus Litseae 3-7 part, bar bar flower 5-9 part, Herba Nicandrae Physaloidis 6-12 part, Herba Artemisiae Scopariae 6-10 part, Herba Camptosori Sibirici 4-10 part, Radix Paeoniae Alba 5-15 part, mountain
Harvest root 8-16 part, Lignum corni macrophyllae 4-8 part, Radix Ginseng 5-10 part, Spica Prunellae 4-8 part, Radix Polygoni Multiflori 6-10 part.
A kind of feed additive preventing and treating mink coccidiosis the most as claimed in claim 1, it is characterised in that by following weight portion
Each component of number is made: Entermorpha 20 parts, Semen Sesami Nigrum 5 parts, arctic shrimp 20 parts, 6 parts of Testa oryzae, Pupa bombycis 10 parts, 8 parts of fish scale, olive oil 5
Part, egg yolk 4 parts, Fructus Ulmus preparatium 5 parts, Semen Torreyae 6 parts, Semen Cucurbitae 8 parts, Semen Myristicae 5 parts, Fructus Mume 4 parts, Fructus Litseae 3 parts, bar bar spend 5 parts,
Herba Nicandrae Physaloidis 6 parts, Herba Artemisiae Scopariae 6 parts, Herba Camptosori Sibirici 4 parts, the Radix Paeoniae Alba 5 parts, Radix Rhodomyrti 8 parts, Lignum corni macrophyllae 4 parts, Radix Ginseng 5 parts, Spica Prunellae 4 parts, what
The Radix Polygoni Multiflori 6 parts.
A kind of feed additive preventing and treating mink coccidiosis the most as claimed in claim 1, it is characterised in that by following weight portion
Each component of number is made: Entermorpha 40 parts, Semen Sesami Nigrum 15 parts, arctic shrimp 40 parts, 14 parts of Testa oryzae, Pupa bombycis 20 parts, 16 parts of fish scale, Fructus Canarii albi
Oil 10 parts, egg yolk 8 parts, Fructus Ulmus preparatium 15 parts, Semen Torreyae 14 parts, Semen Cucurbitae 18 parts, Semen Myristicae 15 parts, Fructus Mume 10 parts, Fructus Litseae 7 parts,
Ba Ba spend 9 parts, Herba Nicandrae Physaloidis 12 parts, Herba Artemisiae Scopariae 10 parts, Herba Camptosori Sibirici 10 parts, the Radix Paeoniae Alba 15 parts, Radix Rhodomyrti 16 parts, Lignum corni macrophyllae 8 parts, Radix Ginseng 10
Part, Spica Prunellae 8 parts, Radix Polygoni Multiflori 10 parts.
A kind of feed additive preventing and treating mink coccidiosis the most as claimed in claim 1, it is characterised in that by following weight portion
Each component of number is made: Entermorpha 30 parts, Semen Sesami Nigrum 10 parts, arctic shrimp 30 parts, 10 parts of Testa oryzae, Pupa bombycis 15 parts, 12 parts of fish scale, Fructus Canarii albi
Oil 8 parts, egg yolk 6 parts, Fructus Ulmus preparatium 10 parts, Semen Torreyae 10 parts, Semen Cucurbitae 13 parts, Semen Myristicae 10 parts, Fructus Mume 7 parts, Fructus Litseae 5 parts, bar
Bar spend 7 parts, Herba Nicandrae Physaloidis 9 parts, Herba Artemisiae Scopariae 8 parts, Herba Camptosori Sibirici 7 parts, the Radix Paeoniae Alba 10 parts, Radix Rhodomyrti 12 parts, Lignum corni macrophyllae 6 parts, Radix Ginseng 8 parts, the summer
Hay 6 parts, Radix Polygoni Multiflori 8 parts.
The preparation method of a kind of feed additive preventing and treating mink coccidiosis the most as claimed in claim 1, it is characterised in that bag
Include following steps:
(1) taking cutability Fructus Amomi Rotundus, add wheat bran, at 155 ± 5 DEG C, bran simmers 15min, every 100kg Semen Myristicae, uses wheat bran 40kg, fries extremely
Wheat bran is coke yellow, and Semen Myristicae is sepia, and the face of wrapping up in is taken out when having crack, and sieve removes wheat bran, cools, standby；
(2) by after Semen Cucurbitae parching to brown, with Fructus Ulmus preparatium, Semen Torreyae, Fructus Mume, Fructus Litseae, Ba Bahua, Herba Nicandrae Physaloidis, Herba Artemisiae Scopariae, Herba Camptosori Sibirici, the Radix Paeoniae Alba,
Grind to 80 mesh after Semen Myristicae mixing after Radix Rhodomyrti, Lignum corni macrophyllae, Radix Ginseng, Spica Prunellae, Radix Polygoni Multiflori and step (1) process,
Gross weight is designated as 1 part, adds 3 parts of sterilized water, 1 part of ethanol, soaks 1h at 50 ± 5 DEG C, then that said medicine is common with liquid
Being placed in microwave extracting tank and extract, control microwave frequency is 1000MHz, and microwave power is 120W/L, carries out microwave radiation,
Then the operating pressure in extractor being stepped up in 5-10min to 0.2MPa, microwave irradiation time amounts to 30min,
Extract；
(3) after the extract of step (2) being decompressed, filter, reclaim ethanol, collect filtrate, carry out filtrate being concentrated into the closeest
Degree is 1.2 ± 0.05, obtains traditional Chinese drug inspissation cream；
(4) by Entermorpha, fish scale clean dry, then Entermorpha, fish scale are ground with Semen Sesami Nigrum, arctic shrimp, Pupa bombycis, with rice
The traditional Chinese drug inspissation cream mixing that bran, egg yolk, olive oil, step (3) prepare, stirs, and sterilizing obtains described feedstuff and adds
Agent.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610370469.3A CN106036132A (en) | 2016-05-30 | 2016-05-30 | Feed additive capable of preventing and treating coccidiosis of minks and preparation method of feed additive |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610370469.3A CN106036132A (en) | 2016-05-30 | 2016-05-30 | Feed additive capable of preventing and treating coccidiosis of minks and preparation method of feed additive |
Publications (1)
| Publication Number | Publication Date |
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| CN106036132A true CN106036132A (en) | 2016-10-26 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101653198A (en) * | 2008-08-20 | 2010-02-24 | 北京康华远景科技有限公司 | Feed additives for preventing and controlling coccidiosis and preparation methods thereof |
| CN101697774A (en) * | 2009-07-24 | 2010-04-28 | 王直军 | Traditional Chinese medicine feed additive for treating chicken coccidiosis |
| CN103947890A (en) * | 2014-05-13 | 2014-07-30 | 山东新希望六和集团有限公司 | Feed and traditional Chinese medicine composition for preventing and treating coccidiosis in duck, and preparation method of feed |
| CN104222631A (en) * | 2014-09-10 | 2014-12-24 | 青岛华仁技术孵化器有限公司 | Feed for treating coccidiosis of rabbits |
-
2016
- 2016-05-30 CN CN201610370469.3A patent/CN106036132A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101653198A (en) * | 2008-08-20 | 2010-02-24 | 北京康华远景科技有限公司 | Feed additives for preventing and controlling coccidiosis and preparation methods thereof |
| CN101697774A (en) * | 2009-07-24 | 2010-04-28 | 王直军 | Traditional Chinese medicine feed additive for treating chicken coccidiosis |
| CN103947890A (en) * | 2014-05-13 | 2014-07-30 | 山东新希望六和集团有限公司 | Feed and traditional Chinese medicine composition for preventing and treating coccidiosis in duck, and preparation method of feed |
| CN104222631A (en) * | 2014-09-10 | 2014-12-24 | 青岛华仁技术孵化器有限公司 | Feed for treating coccidiosis of rabbits |
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Application publication date: 20161026 |