CN103550739A - Traditional Chinese medicinal composition for treating acute enteritis and preparation method of traditional Chinese medicinal composition - Google Patents
Traditional Chinese medicinal composition for treating acute enteritis and preparation method of traditional Chinese medicinal composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for treating acute enteritis, and belongs to the technical field of medicines. The traditional Chinese medicinal composition is prepared from the following raw materials in parts by weight: 10-50 parts of fructus forsythiae, 10-20 parts of notopterygium root, 5-20 parts of angelica, 5-15 parts of scutellaria baicalensis, 5-10 parts of root of rehmannia, 5-15 parts of lily, 5-15 parts of honeysuckle, 1-10 parts of ginseng, 5-15 parts of medlar, 9-15 parts of root of bidentate achyranthes, 9-15 parts of ligusticum wallichii, 5-15 parts of radix angelicae, 0.2-9 parts of radix ophiopogonis, 5.5-15 parts of white paeony root, 6-9 parts of dried ginger and 10-15 parts of liquorice. The traditional Chinese medicinal composition has an excellent treating effect on treating or preventing acute enteritis; and the traditional Chinese medicinal composition is low in medicine side effect and obvious in clinical popularization value.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of Chinese medicine composition for the treatment of acute enteritis.
Background technology
Acute enteritis is modal disease in digestive system disease.Normal and intestinal infection comprises enterovirus (COxsackie, echovirus) and other viruses, antibacterial (as bacillus, Salmonella, staphylococcus aureus, cholera, intestinal are read coccus), intestinal ameba, parasite etc.; Also cause alimentary toxicosis with improper diet, the stale food of excess intake; Chemicals and drug intoxication; Food anaphylaxis is relevant.Clinical manifestation is that diarrhoea, stomachache, abdominal distention are accompanied nausea and vomiting in various degree, when serious, can cause dehydration, even shock.Primary disease can occur in any age, more with summer and autumn, and public health is not good enough, and area is sent out well.
The clinical manifestation of acute enteritis is 1. stomachache: multidigit is in umbilical part, and vexed pain is lighter, can have tenderness in various degree.2. suffer from diarrhoea: cardinal symptom weight differs, Acute onset, for several times to more than 10 times, be yellow watery stool every day, can have foam or a small amount of mucus, and severe patient can be with a small amount of pus and blood.3. have in various degree feel sick, abdominal distention, headache, myasthenia of limbs, severe diarrhea can cause dehydration, electrolyte disturbance, even shock.
At present, the Western medicine for the treatment of acute enteritis is a lot, but most drug therapeutic effect is poor, and treats in addition the shortcomings such as high, side effect is large, even affects patient health when serious.Antibiotic is better to the therapeutic effect of acute enteritis, but antibiotic life-time service can cause human body to produce antibiotic resistance, and the balance of its use meeting destruction intestinal microbial population, has caused serious impact to patient's physical and mental health.In addition, also have the Chinese medicine of a lot for the treatment of acute enteritises, but the shortcoming such as great majority have that therapeutic effect is poor, cure rate is low and treatment cycle is long.
The traditional Chinese medical science thinks, the many gas damp and hot because of being subject to outward, that epidemic disease is malicious of primary disease, and internal injury diet is raw and cold, and impairing the spleen and stomach and internal organs form, and belong to " intestinal is warded off, enteritis " category.The lunar sun of < < Plain Questions is bright by > >, cloud: " eating and drinking without temperance, daily life frequently ... for offering to, let out down, for a long time for intestinal is warded off.", < < Zhengzi Huibu > > points out: " the intestinal person of warding off calls damp and hot amassing in intestinal. be modern enteritis also, therefore say without disease not become to rush down, rush down be wet, heat, food stagnation three ".In treatment, should take the method for determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, < < Jing Yue's complete work > > cloud: " all enteritis of controlling, ought examine deficiency and excess; distinguish cold and heat; this rushes down maximum relation, if four not clear, kills a person very easily also.", therefore that the dialectical head of primary disease distinguishes is cold, hot, empty, real, face card when according to stomachache, tenesmus, rush down color, and refer and synthesize tongue arteries and veins and distinguish.Damp-heat type take stomachache, to rush down lower red white pus and blood, yellow and greasy fur, slippery and rapid pulse be dialectical main points.Pathogenesis is that damp and hot heresy is invaded the intestines and stomach, QI and blood retardance, and stagnation of QI and blood may bring about pain, thus stomachache, tenesmus; Damp and hot stasis is in large intestine, and meridians are impaired, therefore the red white pus and blood that drops; Yellow and greasy fur, slippery and rapid pulse are damp and hot resembling.The suitable clearing away heat and eliminating dampness of the rule for the treatment of, regulating QI promoting the circulation of blood.
Make a general survey of the research direction of world's new drug, be mainly single chemicals and preparations thereof of research and development the eighties in the past, starts to develop biotechnology and natural medicinal plants after the eighties, and drug research direction is tending towards multiformity.In conjunction with modern Chinese medicine theory of development, from improving the angle of curative effect of medication, reduction side effect, through Chinese medicine ingredients being screened to the preparation that extraction and/or compatibility make, its side effect is little, safe, has the advantage that chemical synthetic drug can not be compared.
Summary of the invention
Large in order to overcome existing acute enteritis chemotherapeutic agent toxic and side effects, acute enteritis therapeutic effect is difficult to lasting prior art deficiency, the invention provides a kind of Chinese medicine composition for the treatment of acute enteritis, this Chinese medicine composition good effect, side effect is little, it is mainly made by following raw material: Fructus Forsythiae 10-50 part, Rhizoma Et Radix Notopterygii 10-20 part, Radix Angelicae Sinensis 5-20 part, Radix Scutellariae 5-15 part, Radix Rehmanniae 5-10 part, Bulbus Lilii 5-15 part, Flos Lonicerae 5-15 part, Radix Ginseng 1-10 part, Fructus Lycii 5-15 part, Radix Achyranthis Bidentatae 9-15 part, Rhizoma Chuanxiong 9-15 part, Radix Angelicae Dahuricae 5-15 part, Radix Ophiopogonis 0.2-9 part, Radix Paeoniae Alba 5.5-15 part, Rhizoma Zingiberis 6-9 part, Radix Glycyrrhizae 10-15 part.
Fructus Forsythiae is one of conventional Chinese medicine of Chinese Clinical, has another name called that Hemerocallis citrina Baroni bar, Fructus Forsythiae, green grass or young crops stick up, fall to sticking up, Huang Qidan etc.Fructus Forsythiae recording of < < Pharmacopoeia of People's Republic of China > > version in 2005 is Oleaceae (Oleaceae) Forsythia (Forsythia) plant Fructus Forsythiae (Forsythia suspensa(Thunb.) Vahl) dry fruit, fruit just ripe still gathering when band is green is called green grass or young crops and sticks up, and gathers to be called always and stick up during the well-done color jaundice of fruit.The pharmacological action such as that Fructus Forsythiae has is antibiotic, heart tonifying, diuresis, town are told, the diseases such as the conventional acute anemopyretic cold of forsythia fruit for treating, carbuncle sore tumefacting virus, tuberculous lymphadenitis, urinary tract infection are the primary raw material of the Chinese medicine preparation such as two chuanxiong rhizome oral liquid, two Rhizoma Chuanxiong power injection, QINGRE JIEDU KOUFUYE, the careless analgesic oral liquid of company, flos ionicerae and fructus forsythiae infusion for detoxication.
Rhizoma Et Radix Notopterygii is conventional Chinese medicine.Medicinal history is long, first appeared in < < Sheng Nong's herbal classic > >, lists under Radix Angelicae Pubescentis item.Rhizoma Et Radix Notopterygii bitter in the mouth, pungent, warm in nature.There is loose exterior cold curing rheumatism, the effect in sharp joint.Control affection of exogenous wind-cold, lossless, the anemofrigid-damp arthralgia of having a headache, stiffness of the nape muscular contracture, joint are ached, edema due to wind pathogen edema, the swollen sore of pain etc.Modern analysis shows, Rhizoma Et Radix Notopterygii mainly contains bornene, twists rubber alkene, the compositions such as words product enol and acetic acid Radix Gentianae brain vinegar.Clinical in impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.The diseases such as cold expelling, expelling wind and dampness, pain relieving of inducing sweat.Modern pharmacology research Rhizoma Et Radix Notopterygii has significant antipyretic and anti-inflammatory and paroxysmal pain effect.
When being classified as, conventional enrich blood, regulating menstruation, Traditional Chinese medicine used as analgesic, its sweet-bitter flavor, warm in nature, having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, the effect of moisturizing laxation, cures mainly that all cards of blood deficiency, menoxenia, amenorrhea dysmenorrhea, lump in the abdomen knot are poly-, the disease such as weight, ulcer sores after asthenia cold abdominalgia, numbness of the skin, dryness of the intestine dyschezia, bloody dysentery.Modern pharmacology studies show that it all has multiple pharmacological effect for blood system, cardiovascular system.
Radix Scutellariae another name Radix Scutellariae, tsuchikane tea root.For labiate Radix Scutellariae (Scutellaria baicalensis Georgi), with root, be used as medicine.Have heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibiotic not worse than Rhizoma Chuanxiong, and does not develop immunity to drugs.
The Radix Rehmanniae, another name Radix Rehmanniae, Scrophulariaceae herbaceos perennial has clearing away heat and cooling blood effect for the warm febrile disease blood of joining the army, high fever coma, xerostomia crimson tongue.As qingying decoction.Control the convalescent stage of febrile disease, waste heat not to the greatest extent, hinder by cloudy liquid, night fever abating at dawn, and red tongue rapid pulse person, as QINGHAOBIEJIATANG.Can be used for controlling the warm febrile disease blood of joining the army, heat in blood poison is contained, hematemesis and epistaxis, and macule purple is black.As Sisheng Wan; YIN nourishing and the production of body fluid promoting effect is thirsty for Tianjin wound, and interior-heat is quenched one's thirst.Control epidemic febrile disease impairment of YIN, dryness of the intestine constipation, as Zengye Tang.
The traditional Chinese medical science thinks that Bulbus Lilii has the effect of nourishing the lung to arrest cough, clearing away heart-fire for tranquillization, and especially fresh Bulbus Lilii is more sweet delicious.The people that Bulbus Lilii is particularly suitable for foster lung, nourishing the stomach eats, such as the patient of chronic cough, pulmonary tuberculosis, aphtha of the mouth and tongue, xerostomia, halitosis.Bulbus Lilii not only has good nutritious tonifying effect, and for the patient such as deficient syndrome, tuberculosis, neurosis is of great advantage after being ill, various cancers is had to good curative effect.Aspect the prevention and treatment of tumor, Bulbus Lilii is used for treating pulmonary carcinoma, nasopharyngeal carcinoma, skin carcinoma etc.During the symptoms such as, xerostomia weak in the body void that above-mentioned cancer is carried out occurring after radiotherapy, vexed, dry cough expectorant, with fresh Bulbus Lilii, cook congee together with Semen oryzae sativae, after calling in again appropriate crystal sugar or Mel, eat, reaction to health invigorating, anticancer growth, alleviation radiotherapy, has good effect.For another example, fresh Bulbus Lilii and white sugar are smash to deposited affected part in right amount altogether,, infiltration person hemorrhage to skin carcinoma ulceration also has certain therapeutical effect.
Flos Lonicerae is cold in nature, and sweet in the mouth enters lung, the heart, stomach warp, has the effect of heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treatment wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.Flos Lonicerae tea has unique weight losing function simultaneously, can also suppress and the pathogen of killing bottleneck throat, and old man and child are had to infection effect.So, often take Flos Lonicerae immersion or decoct and be conducive to wind-fire conjunctival congestion, laryngopharynx swelling and pain, obesity, the hypertensive treatment of liver-heat disease regulating liver-QI pattern of fever and rehabilitation.
The medical value of Radix Ginseng is high, in the > > of < < Sheng Nong's herbal classic, just think, Radix Ginseng has the effect of " tonifying five ZANG-organs, peace spirit, determine soul, pathogen, the happy Fructus Alpiniae Oxyphyllae of improving eyesight are throbbed with fear, removed to spasmolytic ".Pharmacological research shows that Radix Ginseng all has the effect of the blood glucose of reduction to Normal Canine and the impatient enteritis dog of alloxan, has obvious hypoglycemic activity to the impatient enteritis Mus of alloxan.After Radix Ginseng total saponins can obviously suppress the hyperglycemia of the impatient enteritis Mus of alloxan and drug withdrawal, its effect still can maintain 1～2 week.Clinical research shows, Radix Ginseng treatment acute enteritis not only can be improved general symptom as weak, thirsty, weak etc., and can reduce blood glucose and glucose in urine.Be applicable to light, medium-sized acute enteritis patient, Chinese medical discrimination is suffered from a deficiency of the kidney, gas deficiency of YIN person better efficacy, and the deficiency of YIN scorching person should not take.
Fructus Lycii (formal name used at school: Lycium chinense) be the multi-branched shrub plant of Solanaceae Lycium, high 0.5-1 rice, can reach more than 2 meters during cultivation.All there is distribution both at home and abroad.Fructus Lycii whole body is precious, and bright Li Shizhen (1518-1593 A.D.) < < Compendium of Materia Medica > > records: " spring is adopted Folium Lycii, name day essence grass; Summer picks flowers, name Sempervivum tectorum; Qiu Caizi, name Fructus Lycii; Dong Caigen, name Cortex Lycii ".Fructus Lycii tender leaf also claims Fructus Lycii head, edible or make Fructus Lycii tea.Modern study, Fructus Lycii has the blood glucose of reduction, lipotropy, and can antiatherogenic effect.
Radix Achyranthis Bidentatae is the plant of Amaranthaceae Achyranthes, and its property bitter but sweet flavor acid is flat, has promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, draws the descending effect of blood (fire), be usually used in treating the gynaecopathia such as amenorrhea, dysmenorrhea, menoxenia, puerperal abdonimal pain of stagnation of blood stasis, traumatic injury, the soreness of waist and knee joint of suffering from a deficiency of the kidney, weakness of the lower extremities, hematuria; dysuria, Urethra astringent pain and intimately go up the cards such as headache that inflammation causes, dizzy, haematemesis, epistaxis.
The pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, the up top, mountain peak that reaches; Enter again blood system, the descending sea of blood that reaches.Blood circulation promoting and blood stasis dispelling effect is extensive, the various diseases of suitable stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.It is the gas medicine in blood that former times people calls Rhizoma Chuanxiong, nearly says the functions such as pungent loose, the resolving depression of its residence, sensible, pain relieving.The pungent temperature rise of this product is loose, and all hyperactivity of YANG due to deficiency of YIN and excessive rising of liver-YANG person should not apply; Menorrhagia, anemia of pregnant woman also avoid use.
The Radix Angelicae Dahuricae, warm in nature, acrid in the mouth is micro-sweet, has expelling wind and removing dampness; Logical surreptitiously pain relieving; The effect of detumescence and apocenosis.Main headache due to common cold; Supraorbital bone pain; Toothache; Nasal obstruction; Nasal sinusitis; Domination of damp pathogen chronic diarrhea; Women leucorrhea; Ulcer sores; Venom.Clinical in headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.Also can be used for the cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis.Control headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Rhizoma Atractylodis have drying damp and strengthening spleen, expelling wind and cold, and the effect of improving eyesight, for dampness taste, distension and fullness in the abdomen, cold-damp leucorrhea, damp-warm diseases and damp invasion of lower energizer, foot swelling and pain in knee, flaccidity are soft unable.Control dampness taste, and see the thick disease such as turbid of distension and fullness in the abdomen, inappetence, fatigue and weakness, white and greasy fur, the compatibilities such as normal and Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae are applied.
Radix Ophiopogonis, has another name called Radix Ophiopogonis, is Liliaceae Ophiopogon plant.Be used as medicine Radix Ophiopogonis with tuber.Nature,taste and action: sweet, micro-hardship, cool, Yin-nourishing and body fluid promoting, nourishing the lung to arrest cough, relieving restlessness clears away heart-fire.Cure mainly consumption of body fluid caused by febrile disease, vexed, thirsty, dry pharynx lung-heat, cough, pulmonary tuberculosis.
The Radix Paeoniae Alba is the famous traditional parts of generic medicinal plants of China, applicating history is long, and Radix Paeoniae begins to be loaded in the < < of Eastern Han Dynasty Sheng Nong's herbal classic > >, classifies middle product as, note has " main pathogen; Radix Paeoniae Alba stomachache, except arthralgia due to stagnation of blood, broken hard long-pending; cold and heat hernia abdominal mass; pain relieving, diuresis, QI invigorating ".Nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, is with inferior disease.Modern pharmacology studies show that, paeoniflorin is to the intestine in vitro of Cavia porcellus, rat with in stomach motion, and rat uterus smooth muscle all shows inhibition, and can the caused contraction of antagonism oxytocin; With acetic acid injection, in mouse peritoneal, using writhing response as the index of pain, paeoniflorin has significant analgesic effect; The caused convulsions of extractum energy antagonism strychnine of Radix Paeoniae; Radix Paeoniae Alba decoct has bacteriostasis to dysentery bacterium in vitro, and preserved material also has inhibitory action to some pathogenic fungus.Paeoniflorin has cooling effect to white mice normal body temperature, and the mice of artificial fever is also had to refrigeration function.Rat experiment metapedes sole of the foot edema is had to antiinflammatory action; Paeoniflorin has inhibitory action to the rat platelet aggregation of adenosine diphosphate (ADP) induction in vitro or during intravenous injection; Paeoniflorin has obvious inhibitory action to irritate the digestive tract in rats ulcer of bringing out due to anxiety.
Rhizoma Zingiberis < < Sheng Nong's herbal classic > > classifies middle product as, and Rhizoma Zingiberis Recens < < Mingyi Bielu > > classifies middle product as.TAO Hong-Jing meaning: " all Rhizoma Zingiberis methods of doing: water logging three days, peeling is put in flowing water six, and more random peeling, then dries, and puts in Porcelain Jar and makes three, is into." Li Shizhen (1518-1593 A.D.) meaning Rhizoma Zingiberis makes it with female Rhizoma Zingiberis Recens, take fair and clear solid person as good, all being used as medicine and Yi Pao use.Rhizoma Zingiberis, for warm spleen sun, is partially controlled spleen-cold syndrome stomachache and has loose bowels.Can promote blood circulation by recuperating depleted YANG again, warming the lung to resolve fluid-retention, with controlling yang depletion syndrome, extremity are fainted contrary, faint pulse being about to disappear, and cold fluid-retention cough with asthma, the cold physique back of the body is cold, the clear rare disease of waiting of abundant expectoration.
Radix Glycyrrhizae, QI invigorating invigorating middle warmer; Relieving spasm to stop pain; Nourishing the lung to arrest cough; Eliminating fire and detoxication; Coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite; Leanness yellowish complexion; Shortness of breath and palpitation; Stomachache loose stool; The anxious pain of extremity contraction; Hysteria; Cough and asthma; Laryngopharynx swelling and pain; Carbuncle skin ulcer swells and ache; Infantile carbuncle; And medicine, alimentary toxicosis.Western modern medicine haircut is existing, and Radix Glycyrrhizae agent has the function of antiinflammatory and the reflection of resistance state, therefore in doctor trained in Western medicine clinically mainly as demulcent.Relieving cough, eliminates the phlegm, treatment pharyngalgia laryngitis; Radix Glycyrrhizae or enoxolone have the effect of desoxycortone class, and chronic adrenocortical hypofunction is had to good efficacy; Glycyrrhiza preparation can promote stomach mucus to form and secretion, extends the epithelial cell life-span, has anti-inflammatory activity, is usually used in the treatment of chronic ulcer and duodenal ulcer; The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect; Radix Glycyrrhizae is also one of primary raw material of rendan mini-pills.
Chinese medicine composition of the present invention on Chinese medicinal components is selected, take except long-pending numbness, dispersing wind and cold, wind-damp dispelling, bone and muscle strengthening be main standard, after Chinese medicine composition combination of the present invention, there is significant antiinflammatory, analgesia and activating blood circulation to dissipate blood stasis effect.The present invention has carried out preferably the parts by weight of above-mentioned all taste Chinese medicine, and preferred condition is the enhancing of medicine to acute enteritis therapeutic effect after drug matching is used.As a preferred embodiment of the present invention, Chinese medicine composition of the present invention is mainly made by the raw material of following weight portion: 30 parts of Fructus Forsythiaes, 15 parts of Rhizoma Et Radix Notopterygiis, 15 parts of Radix Angelicae Sinensis, 10 parts of Radix Scutellariaes, 8 parts, the Radix Rehmanniae, 10 parts of Bulbus Liliies, 10 parts of Flos Loniceraes, 6 parts of Radix Ginsengs, 10 parts of Fructus Lyciis, 12 parts of Radix Achyranthis Bidentataes, 12 parts of Rhizoma Chuanxiongs, 10 parts of the Radixs Angelicae Dahuricae, 5.5 parts of Radix Ophiopogonis, 10 parts of the Radix Paeoniae Albas, 8 parts of Rhizoma Zingiberiss, 12 parts, Radix Glycyrrhizae.
Preferably, Chinese medicine composition of the present invention also further contains 7 parts of the Radix Aucklandiae, 5 parts of Fructus Citris, 9 parts of Radix Polygalaes.Radix Aucklandiae acrid in the mouth, hardship, warm in nature; Return spleen, stomach, liver, large intestine channel, fragrance row is loose, can rise and can fall.It has following effect: promoting the circulation of QI to relieve pain, for abdominal distention, lack of appetite due to stagnation of QI in spleen and stomach, vomit; Regulate the flow of vital energy soothing the liver, hypochondriac pain 3. spleen invigorating that cause for QI stagnation of the liver and galibladder disappear stagnant, the stagnant gas of adjustable gastrointestinal.Treatment stomachache, diarrhoea, tenesmus.Fructus Citri has another name called citron, is Rutaceae citrus plant, and Fructus Citri acrid in the mouth, micro-hardship, acid are warm in nature; Return liver, lung, spleen channel; The fragrant row of gas is loose, can rise and can fall; Have depressed liver-energy dispersing and QI regulating, the chest stuffiness relieving reduces phlegm, dehumidifying and in effect, cure mainly distending pain in the chest and hypochondrium, cough with copious phlegm, gastral cavity abdomen painful abdominal mass pain, dyspepsia vomiting, edema beriberi.Radix Polygalae is conventional Chinese medicine, be recorded in the earliest < < Sheng Nong's herbal classic > >, classify as top gradely, and be regarded as supporting life key medicine, warm in nature, bitter in the mouth, pungent, the function of there is the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling, the insomnia and dreamful sleep causing for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.
In order to express better Chinese medicine composition of the present invention, Chinese medicine composition of the present invention can be prepared into conventional clinically dosage form.Such as, the preparations such as powderous preparations, powder, pill, sublimed preparation, unguentum, granule, oral liquid, syrup, tablet, capsule.Preferably, Chinese medicine composition of the present invention is prepared into powder, water preparation, tablet or capsule according to conventional preparation technology.
The present invention also provides a kind of preparation method of Chinese medicine composition described above, it mainly comprises following step: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, according to 4～9 times of coarse powder gross weight, adding volumetric concentration is 40%～95% alcoholic solution, reflux, extract, three times, return time is 2～5h, filters, filtrate recycling ethanol, cold filtration, washes with water, after being dried, obtains Chinese medical concrete; Those skilled in the art can be at the technical conventional Chinese medicine pharmaceutical dosage form clinically for preparing of this preparation method, as tablet, capsule etc.
The present invention also asks for protection the purposes of above-mentioned Chinese medicine composition in preparation treatment acute enteritis medicine.Pharmaceutical composition of the present invention, when treatment acute enteritis, demonstrates significant anti-inflammatory and antalgic, activating blood circulation to dissipate blood stasis activity.Drug effect embodiment of the present invention 19 shows, with model group comparison, the low middle Senior Three of a Chinese medicine composition of the present invention dosage group all can significantly reduce dimethylbenzene induced mice ear swelling value (
p< 0.01), show that Chinese medicine composition of the present invention has the effect of the mice ear of remarkable inhibition dimethylbenzene induction, and there is significant dose-effect relationship in its reduction effect to ear swelling.Under same experiment condition, positive control drug enteritis curing capsule group also significantly reduce ear swelling value (
p< 0.05), but its antiphlogistic effects is obviously not as good as Chinese medicine composition of the present invention.Drug effect embodiment 20 of the present invention shows, mice licks foot response latency time showing, with model group comparison, after administration after 1h and 2h, all be greater than model group the incubation period that the mice of each administration group of Chinese medicine composition of the present invention is added foot reaction, there is dose-dependence, and be significantly greater than the incubation period of high dose group model group (
p< 0.05).Illustrate that this Chinese medicine composition of the present invention can extend adding the sufficient response latency that mice stimulates hot plate, has certain analgesic activity.Under same experiment condition, positive control drug Rifaximin capsule group (
p< 0.05) and enteritis curing capsule group (1h,
p< 0.05; 2h,
p< 0.01) also significant prolongation mice incubation period of adding foot reaction, have certain analgesic activity.Drug effect embodiment of the present invention 21 shows, model group and normal control comparison, the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity all have significantly and increase (
p<0.05).With model group comparison, basic, normal, high each dosage group of the Chinese medicine composition of the present invention all remarkable or utmost point has reduced the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity significantly, reduction amplitude amount effect relationship, wherein high dose there were significant differences (
p<0.05).Under same experiment condition, positive control drug Rifaximin capsule group has also reduced the high cut index of whole blood, the low cut index of whole blood, erythrocyte aggregation index, but it improves effect all not as good as Chinese medicine composition of the present invention to hemorheology index.The result statistics of liver index shows, model group and normal control comparison, and liver index significantly increases.And with model group comparison, basic, normal, high each dosage group of Chinese medicine composition of the present invention significantly reduced liver index (
p<0.01), positive control drug Rifaximin capsule and Chinese medicine composition of the present invention Chinese medicine composition high dose group of the present invention can reduce significantly liver index (
p<0.05), but effect not as good as Chinese medicine composition of the present invention.Embodiment 22 results show, Chinese medicine composition of the present invention all has good fungistatic effect to most pathogenic entero becteria, this shows that Chinese medicine composition of the present invention all has significant therapeutic effect for the acute enteritis of various bacteria or fungus initiation, can play to infectious acute enteritis the effect for the treatment of both the principal and secondary aspects of a disease.And more estimable, in Chinese medicine composition of the present invention, contain plurality of active ingredients, during for acute enteritis treatment of infection, target spot is many, be difficult for to produce drug resistance, be significantly better than existing clinical in widely used antibiotics.
In a word, pharmaceutical composition of the present invention, aspect treatment acute enteritis, compared with prior art has following advantage:
1) compare with positive control drug Rifaximin capsule or enteritis curing capsule, pharmaceutical composition Chinese medicine composition of the present invention is not only more remarkable at antiinflammatory and ease pain, and aspect activating blood circulation to dissipate blood stasis, be also significantly better than positive drug, this shows that the present composition has significant synergism in acute enteritis treatment, not only can significantly improve the symptom of acute enteritis, can also delay the development of acute enteritis, contribute to acute enteritis patient's recovery from illness process.
2) compare with the chemotherapeutic agent of current treatment acute enteritis, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, particularly it does not produce any destruction for intestinal mucosa, and Chinese medicine composition effect of the present invention is comprehensive, medication effect is better, has significantly improved acute enteritis patient's compliance, and has improved patient's quality of life.
3) existing antibiotic medicine acute enteritis initial stage therapeutic effect still can, but along with obvious drug resistance problem all appears in the prolongation for the treatment of time, its therapeutic effect for acute enteritis declines.In Chinese medicine composition of the present invention, contain multi-medicament component, action target spot is numerous, has effectively solved the Commpensation And Adaptation of acute enteritis medicine, its to the therapeutic effect of acute enteritis not because treatment time extends and to decline.
The specific embodiment
By specific embodiment, further describe the present invention below, the present invention is not limited only to following examples.Within the scope of the invention or within not departing from content of the present invention, spirit and scope, the change that the present invention is carried out, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
first's Chinese medicinal composition preparation of the present invention, preparation and using method thereof
embodiment 1-6 Chinese medicine composition composition powders
Embodiment 1 prescription: Fructus Forsythiae 30g, Rhizoma Et Radix Notopterygii 15g, Radix Angelicae Sinensis 5g, Radix Scutellariae 5g, Radix Rehmanniae 10g, Bulbus Lilii 15g, Flos Lonicerae 10g, Radix Ginseng 10g, Fructus Lycii 10g, Radix Achyranthis Bidentatae 10g, Rhizoma Chuanxiong 10g, Radix Angelicae Dahuricae 10g, Radix Ophiopogonis 9g, Radix Paeoniae Alba 15g, Rhizoma Zingiberis 6g, Radix Glycyrrhizae 10g, Radix Aucklandiae 7g, Fructus Citri 5g, Radix Polygalae 9g.
Embodiment 2 prescription: Fructus Forsythiae 30g, Rhizoma Et Radix Notopterygii 15g, Radix Angelicae Sinensis 10g, Radix Scutellariae 10g, Radix Rehmanniae 10g, Bulbus Lilii 15g, Flos Lonicerae 10g, Radix Ginseng 10g, Fructus Lycii 10g, Radix Achyranthis Bidentatae 10g, Rhizoma Chuanxiong 10g, Radix Angelicae Dahuricae 10g, Radix Ophiopogonis 8g, Radix Paeoniae Alba 5.5g, Rhizoma Zingiberis 8g, Radix Glycyrrhizae 10g, Radix Aucklandiae 7g, Fructus Citri 5g, Radix Polygalae 9g.
Embodiment 3 prescription: Fructus Forsythiae 30g, Rhizoma Et Radix Notopterygii 15g, Radix Angelicae Sinensis 10g, Radix Scutellariae 15g, Radix Rehmanniae 5g, Bulbus Lilii 5g, Flos Lonicerae 10g, Radix Ginseng 10g, Fructus Lycii 10g, Radix Achyranthis Bidentatae 9g, Rhizoma Chuanxiong 10g, Radix Angelicae Dahuricae 10g, Radix Ophiopogonis 8g, Rhizoma Zingiberis 7g, Radix Glycyrrhizae 12g, Radix Aucklandiae 7g, Fructus Citri 5g, Radix Polygalae 9g.
Embodiment 4 prescription: Fructus Forsythiae 30g, Rhizoma Et Radix Notopterygii 15g, Radix Angelicae Sinensis 20g, Radix Scutellariae 10g, Radix Rehmanniae 8g, Bulbus Lilii 10g, Flos Lonicerae 10g, Radix Ginseng 10g, Fructus Lycii 10g, Radix Achyranthis Bidentatae 12g, Rhizoma Chuanxiong 10g, Radix Angelicae Dahuricae 5.5g, Radix Ophiopogonis 8g, Radix Paeoniae Alba 10g, Rhizoma Zingiberis 7g, Radix Glycyrrhizae 15g, Radix Aucklandiae 7g, Fructus Citri 5g, Radix Polygalae 9g.
Embodiment 5 prescription: Fructus Forsythiae 50g, Rhizoma Et Radix Notopterygii 20g, Radix Angelicae Sinensis 15g, Radix Scutellariae 15g, Radix Rehmanniae 10g, Bulbus Lilii 10g, Flos Lonicerae 15g, Radix Ginseng 1g, Fructus Lycii 15g, Radix Achyranthis Bidentatae 10g, Rhizoma Chuanxiong 15g, Radix Angelicae Dahuricae 15g, Radix Ophiopogonis 0.2g, Radix Paeoniae Alba 15g, Rhizoma Zingiberis 9g, Radix Glycyrrhizae 15g, Radix Aucklandiae 7g, Fructus Citri 5g, Radix Polygalae 9g.
Embodiment 6 prescription: Fructus Forsythiae 10g, Rhizoma Et Radix Notopterygii 10g, Radix Angelicae Sinensis 15g, Radix Scutellariae 5g, Radix Rehmanniae 5g, Bulbus Lilii 5g, Flos Lonicerae 5g, Radix Ginseng 5g, Fructus Lycii 5g, Radix Achyranthis Bidentatae 15g, Rhizoma Chuanxiong 9g, Radix Angelicae Dahuricae 9g, Radix Ophiopogonis 5g, Radix Paeoniae Alba 15g, Rhizoma Zingiberis 9g, Radix Glycyrrhizae 12g, Radix Aucklandiae 7g, Fructus Citri 5g, Radix Polygalae 9g.
Embodiment 1 preparation method: get each medical material in compositions, grind to form powdery according to common process, cross 100 mesh sieves, little fire drying is standby, obtains powder.During use, with directly taking after mixing it with water after water dissolution.Embodiment 2-6 preparation method is with embodiment 1.
embodiment 7-12 Chinese medicine composition water preparation
Embodiment 7 prescription: Fructus Forsythiae 30g, Rhizoma Et Radix Notopterygii 15g, Radix Angelicae Sinensis 5g, Radix Rehmanniae 10g, Radix Scutellariae 5g, Bulbus Lilii 15g, Flos Lonicerae 10g, Radix Ginseng 10g, Fructus Lycii 10g, Radix Achyranthis Bidentatae 10g, Rhizoma Chuanxiong 10g, Radix Angelicae Dahuricae 10g, Radix Ophiopogonis 9g, Radix Paeoniae Alba 15g, Rhizoma Zingiberis 6g, Radix Glycyrrhizae 10g.
Embodiment 8 prescription: Fructus Forsythiae 30g, Rhizoma Et Radix Notopterygii 15g, Radix Angelicae Sinensis 10g, Radix Rehmanniae 10g, Radix Scutellariae 10g, Bulbus Lilii 15g, Flos Lonicerae 10g, Radix Ginseng 10g, Fructus Lycii 10g, Radix Achyranthis Bidentatae 10g, Rhizoma Chuanxiong 10g, Radix Angelicae Dahuricae 10g, Radix Ophiopogonis 8g, Radix Paeoniae Alba 5.5g, Rhizoma Zingiberis 8g, Radix Glycyrrhizae 10g.
Embodiment 9 prescription: Fructus Forsythiae 30g, Rhizoma Et Radix Notopterygii 15g, Radix Angelicae Sinensis 10g, Radix Rehmanniae 5g, Radix Scutellariae 15g, Bulbus Lilii 5g, Flos Lonicerae 10g, Radix Ginseng 10g, Fructus Lycii 10g, Radix Achyranthis Bidentatae 9g, Rhizoma Chuanxiong 10g, Radix Angelicae Dahuricae 10g, Radix Ophiopogonis 8g, Rhizoma Zingiberis 7g, Radix Glycyrrhizae 12g.
Embodiment 10 prescription: Fructus Forsythiae 30g, Rhizoma Et Radix Notopterygii 15g, Radix Angelicae Sinensis 20g, Radix Rehmanniae 8g, Radix Scutellariae 10g, Bulbus Lilii 10g, Flos Lonicerae 10g, Radix Ginseng 10g, Fructus Lycii 10g, Radix Achyranthis Bidentatae 12g, Rhizoma Chuanxiong 10g, Radix Angelicae Dahuricae 5.5g, Radix Ophiopogonis 8g, Radix Paeoniae Alba 10g, Rhizoma Zingiberis 7g, Radix Glycyrrhizae 15g.
Embodiment 11 prescription: Fructus Forsythiae 50g, Rhizoma Et Radix Notopterygii 20g, Radix Angelicae Sinensis 15g, Radix Rehmanniae 10g, Radix Scutellariae 15g, Bulbus Lilii 10g, Flos Lonicerae 15g, Radix Ginseng 1g, Fructus Lycii 15g, Radix Achyranthis Bidentatae 10g, Rhizoma Chuanxiong 15g, Radix Angelicae Dahuricae 15g, Radix Ophiopogonis 0.2g, Radix Paeoniae Alba 15g, Rhizoma Zingiberis 9g, Radix Glycyrrhizae 15g.
Embodiment 12 prescription: Fructus Forsythiae 10g, Rhizoma Et Radix Notopterygii 10g, Radix Angelicae Sinensis 15g, Radix Rehmanniae 5g, Radix Scutellariae 5g, Bulbus Lilii 5g, Flos Lonicerae 5g, Radix Ginseng 5g, Fructus Lycii 15g, Radix Achyranthis Bidentatae 15g, Rhizoma Chuanxiong 9g, Radix Angelicae Dahuricae 9g, Radix Ophiopogonis 5g, Radix Paeoniae Alba 15g, Rhizoma Zingiberis 9g, Radix Glycyrrhizae 12g.
Embodiment 7 preparation methoies: get each medical material in prescription, according to conventional decocting for Chinese herbal medicine technological operation, filtering medicinal residues and get final product.When this water preparation (or claiming decoction) is treated for acute enteritis, take 2-3 every day.Embodiment 8-12 preparation method and using method are with embodiment 7.
embodiment 13-18 Chinese medicine composition tablet/capsule of the present invention
Embodiment 13 prescription: Fructus Forsythiae 30g, Rhizoma Et Radix Notopterygii 15g, Radix Angelicae Sinensis 15g, Radix Scutellariae 10g, Radix Rehmanniae 5g, Bulbus Lilii 10g, Flos Lonicerae 5g, Radix Ginseng 10g, Fructus Lycii 10g, Radix Achyranthis Bidentatae 10g, Rhizoma Chuanxiong 10g, Radix Angelicae Dahuricae 15g, Radix Ophiopogonis 0.2g, Radix Paeoniae Alba 10g, Rhizoma Zingiberis 6g, Radix Glycyrrhizae 10g, Radix Aucklandiae 7g, Fructus Citri 5g, Radix Polygalae 9g.
Embodiment 14 prescription: Fructus Forsythiae 30g, Rhizoma Et Radix Notopterygii 15g, Radix Angelicae Sinensis 15g, Radix Scutellariae 10g, Radix Rehmanniae 10g, Bulbus Lilii 10g, Flos Lonicerae 10g, Radix Ginseng 10g, Fructus Lycii 10g, Radix Achyranthis Bidentatae 10g, Rhizoma Chuanxiong 10g, Radix Angelicae Dahuricae 10g, Radix Ophiopogonis 0.2g, Radix Paeoniae Alba 8.5g, Rhizoma Zingiberis 7.5g, Radix Glycyrrhizae 10g, Radix Aucklandiae 7g, Fructus Citri 5g, Radix Polygalae 9g.
Embodiment 15 prescription: Fructus Forsythiae 30g, Rhizoma Et Radix Notopterygii 15g, Radix Angelicae Sinensis 15g, Radix Scutellariae 10g, Radix Rehmanniae 5g, Bulbus Lilii 10g, Flos Lonicerae 5g, Radix Ginseng 10g, Fructus Lycii 10g, Radix Achyranthis Bidentatae 10g, Rhizoma Chuanxiong 10g, Radix Angelicae Dahuricae 10g, Radix Ophiopogonis 9g, Radix Paeoniae Alba 5.5g, Rhizoma Zingiberis 7.5g, Radix Glycyrrhizae 12g, Radix Aucklandiae 7g, Fructus Citri 5g, Radix Polygalae 9g.
Embodiment 16 prescription: Fructus Forsythiae 45g, Rhizoma Et Radix Notopterygii 18.5g, Radix Angelicae Sinensis 16.5g, Radix Scutellariae 15g, Radix Rehmanniae 7.5g, Bulbus Lilii 15g, Flos Lonicerae 7.5g, Radix Ginseng 7.5g, Fructus Lycii 15g, Radix Achyranthis Bidentatae 15g, Rhizoma Chuanxiong 12g, Radix Angelicae Dahuricae 12.5g, Radix Ophiopogonis 6g, Radix Paeoniae Alba 15g, Rhizoma Zingiberis 9g, Radix Glycyrrhizae 10.2g, Radix Aucklandiae 7g, Fructus Citri 5g, Radix Polygalae 9g.
Embodiment 17 prescription: Fructus Forsythiae 50g, Rhizoma Et Radix Notopterygii 20g, Radix Angelicae Sinensis 20g, Radix Scutellariae 15g, Radix Rehmanniae 5g, Bulbus Lilii 15g, Flos Lonicerae 15g, Radix Ginseng 7.5g, Fructus Lycii 15g, Radix Achyranthis Bidentatae 15g, Rhizoma Chuanxiong 15g, Radix Angelicae Dahuricae 7.5g, Radix Ophiopogonis 5.5g, Radix Paeoniae Alba 11g, Rhizoma Zingiberis 9g, Radix Glycyrrhizae 15g, Radix Aucklandiae 7g, Fructus Citri 5g, Radix Polygalae 9g.
Embodiment 18 prescription: Fructus Forsythiae 10g, Rhizoma Et Radix Notopterygii 10g, Radix Angelicae Sinensis 5g, Radix Scutellariae 5g, Radix Rehmanniae 5g, Bulbus Lilii 5g, Flos Lonicerae 5g, Radix Ginseng 1g, Fructus Lycii 9g, Radix Achyranthis Bidentatae 9g, Rhizoma Chuanxiong 9g, Radix Angelicae Dahuricae 5g, Radix Ophiopogonis 9g, Radix Paeoniae Alba 13.5g, Rhizoma Zingiberis 8g, Radix Glycyrrhizae 12g, Radix Aucklandiae 7g, Fructus Citri 5g, Radix Polygalae 9g.
Embodiment 13 preparation technologies: each traditional Chinese medicine powder of getting recipe quantity is broken into coarse powder, according to 5 times of coarse powder gross weight, adding volumetric concentration is 80% alcoholic solution, reflux, extract, three times, the each 3h of return time, filters filtrate recycling ethanol, cold filtration, washes with water, after being dried, obtains Chinese medical concrete; Chinese medical concrete drying, pulverizing are made to dried cream powder, add conventional adjunct ingredient to utilize prior art to be prepared into tablet or capsule.
Embodiment 14-18 preparation technology is with embodiment 13.
second portion Chinese medicine composition pharmacodynamic study of the present invention
embodiment 19 Chinese medicine composition xylol of the present invention causes the impact of mice ear
Get 72 of healthy ICR mices, ♀ ♂ half and half, divide 6 groups, 12/group, be model group, Rifaximin capsule (Hainan company limited of SANYE pharmaceutical factory, lower same), enteritis curing capsule group (Haikou Kangliyuan Pharmaceutical Co., Ltd), Chinese medicine composition of the present invention (making by Chinese medicine composition prescription and preparation technology described in embodiment 1) low dose group, middle dosage group and high dose group.1 time/d of every administration; Administration 14 d, 60 min after last medicine, mouse right ear is evenly smeared dimethylbenzene 0.03 mL/ and is only caused swollenly, cuts ears and beat auricle and weigh after 2h, calculates ear swelling value (mg).Swelling value=auris dextra weight-left ear weight.
Result shows, with model group comparison, the low middle Senior Three of a Chinese medicine composition of the present invention dosage group all can significantly reduce dimethylbenzene induced mice ear swelling value (
p< 0.01), show that Chinese medicine composition of the present invention has the effect of the mice ear of remarkable inhibition dimethylbenzene induction, and there is significant dose-effect relationship in its reduction effect to ear swelling.Under same experiment condition, positive control drug enteritis curing capsule group also significantly reduce ear swelling value (
p< 0.05), but its antiphlogistic effects is obviously not as good as Chinese medicine composition of the present invention.
the impact of table 1 Chinese medicine composition xylol of the present invention induced mice ear swelling (
)
Note: with model group comparison, *
p< 0.05, * *
p< 0.01.
the impact of embodiment 20 Chinese medicine composition of the present invention on mice hot-plate analgesia
1 mice hot plate pain model is made
Body weight 20g left and right female mice is placed on hot plate dolorimeter, screen 90 of qualified ♀ mices and (lick metapedes time < 5 s or > 30 s throw aside, for preventing foot, scald, also should establish deadline, be generally 60s), be the threshold of pain index incubation period that the mice of take is added metapedes reaction, get 72 jennies, be divided into 6 groups, 12/group, it is model group, Rifaximin capsule, enteritis curing capsule group, Chinese medicine composition of the present invention (making by Chinese medicine composition prescription and preparation technology described in embodiment 1) low dose group, middle dosage group and high dose group.Each group is gastric infusion, and 1 times/day, dosage is as shown in table 10, after successive administration 14d, and the time that after mensuration last medicine, 60 min, 120 min add foot reaction.
chinese medicine composition of the present invention is on licking the impact of foot response latency in the experiment of mice hot-plate analgesia
Mice licks foot response latency time showing, with model group comparison, after administration after 1h and 2h, be all greater than model group the incubation period that the mice of each administration group of Chinese medicine composition of the present invention is added foot reaction, there is dose-dependence, and be significantly greater than the incubation period of high dose group model group (
p< 0.05).Illustrate that this Chinese medicine composition of the present invention can extend adding the sufficient response latency that mice stimulates hot plate, has certain analgesic activity.Under same experiment condition, positive control drug Rifaximin capsule group (
p< 0.05) and enteritis curing capsule group (1h,
p< 0.05; 2h,
p< 0.01) also significant prolongation mice incubation period of adding foot reaction, have certain analgesic activity.The results are shown in Table 2.
table 2 mice lick foot response latency timetable (
)
Note: with model group comparison, *
p< 0.05, * *
p< 0.01.
the improvement effect of embodiment 21 Chinese medicine composition of the present invention to rat blood stasis models
Get healthy SD rat, body weight 180-200g, 70, male and female half and half, by body weight, be divided at random 7 groups: basic, normal, high group of Normal group, model group, Rifaximin capsule group, enteritis curing capsule group and Chinese medicine composition of the present invention (by Chinese medicine composition prescription and preparation technology described in embodiment 1, making), 10 every group.Gastric infusion, successive administration 14 days, Normal group and model group are to 0.5%CMC, and all the other give corresponding medicine, and dosage is as shown in table 14.Administration the 13rd day, 14 days, except Normal group, all the other treated animals are pressed 1mg/Kg subcutaneous injection adrenalin hydrochloride, and 2 times/day, interval 4h, after injection, 2h puts animal in 4 ℃ of frozen water 15min for the first time.Administration is got 4-5ml blood anticoagulant heparin on the 15th day and is measured blood rheology parameter, gets the liver conversion organ coefficient of weighing.
Result shows, model group and normal control comparison, the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity all have significantly and increase (
p<0.05).With model group comparison, basic, normal, high each dosage group of the Chinese medicine composition of the present invention all remarkable or utmost point has reduced the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity significantly, reduction amplitude amount effect relationship, wherein high dose there were significant differences (
p<0.05).Under same experiment condition, positive control drug Rifaximin capsule group and enteritis curing capsule group have also reduced the high cut index of whole blood, the low cut index of whole blood, erythrocyte aggregation index, but it improves effect all not as good as Chinese medicine composition of the present invention to hemorheology index.The result statistics of liver index shows, model group and normal control comparison, and liver index significantly increases.And with model group comparison, basic, normal, high each dosage group of Chinese medicine composition of the present invention significantly reduced liver index (
p<0.01), positive control drug Rifaximin capsule and Chinese medicine composition of the present invention Chinese medicine composition high dose group of the present invention can reduce significantly liver index (
p<0.05), but effect not as good as Chinese medicine composition of the present invention.
the impact that table 3 Chinese medicine composition of the present invention becomes rat blood stasis models blood flow (
)
Note: with normal control comparison, #
p< 0.05, ##
p< 0.01; With model group comparison, *
p< 0.05, * *
p< 0.01.
table 4 Chinese medicine composition of the present invention on the impact of rat blood stasis models liver coefficient (
)
Note: with normal control comparison, ##
p< 0.01; With model group comparison, *
p< 0.05, * *
p< 0.01.
the In Vitro Bacteriostasis experiment of embodiment 22 Chinese medicine composition of the present invention to common intestinal malignant bacteria
1, experiment material and method
The strain that this experiment is used and culture medium are respectively Candida albicans, dysentery bacterium, colon bacillus, proteus vulgaris, Salmonella, shigella dysenteriae, staphylococcus aureus, resistance to methoxy staphylococcus aureus and campylobacter jejuni, clostridium perfringens enterotoxin, nutrient agar (Nat'l Pharmaceutical & Biological Products Control Institute); Opacity tube (Chinese bacterial turbidity standard, the biological combinations calibrating of Chinese medicine institute).
In Vitro Bacteriostasis experiment: 1. prepare pastille agar plate.Tested material is pressed to the culture medium of doubling dilution preparation different pharmaceutical concentration, heating, modulation is required pH value separately, and 121 ℃ of sterilizing 30 min, are chilled to 45 ℃.Pour into into aseptic flat board (plate d=65 mm, 10 ml/ plates), finally make the extension rate containing tested material stock solution (2g/ml) in culture medium be respectively l:2,1:4 ... 1:1024.Do blank culture medium separately simultaneously.2. inoculation.Get the bacterium in young age that reaches the third generation, with 0.9% sodium chloride solution, by standard opacity tube corrected concentrations, be respectively the bacterium liquid to be checked of 108 cfu/ml, be inoculated in respectively the agar surface of pastille separately of different doubling dilutions, inoculate parallel point 3 points simultaneously, make at every containing 2 one bacterium liquid.The liquid-drop diameter of each vaccination is 5-8 mm.After vaccination is dry, upset is dull and stereotyped cultivates 20 h observed results (simultaneously doing blank) in 36 ℃ of constant incubators.3. criterion.Take and do not occur that the minimum dilution tested material concentration on the agar plate of bacterium colony is its minimum inhibitory concentration (MIC).In this experiment, Chinese medicine composition is as shown in table 8 to the minimal inhibitory concentration of each pathogenic strain.
, experimental result and analysis
the minimal inhibitory concentration measurement result that table 5 arctigenin is lived common pathogen
Result shows, Chinese medicine composition of the present invention all has good fungistatic effect to most pathogenic entero becteria, this shows that Chinese medicine composition of the present invention all has significant therapeutic effect for the acute enteritis of various bacteria or fungus initiation, can play to infectious acute enteritis the effect for the treatment of both the principal and secondary aspects of a disease.And more estimable, in Chinese medicine composition of the present invention, contain plurality of active ingredients, during for acute enteritis treatment of infection, target spot is many, be difficult for to produce drug resistance, be significantly better than existing clinical in widely used antibiotics.
Claims (6)
1. treat a Chinese medicine composition for acute enteritis, it is characterized in that the main raw material by following weight portion makes: Fructus Forsythiae 10-50 part, Rhizoma Et Radix Notopterygii 10-20 part, Radix Angelicae Sinensis 5-20 part, Radix Scutellariae 5-15 part, Radix Rehmanniae 5-10 part, Bulbus Lilii 5-15 part, Flos Lonicerae 5-15 part, Radix Ginseng 1-10 part, Fructus Lycii 5-15 part, Radix Achyranthis Bidentatae 9-15 part, Rhizoma Chuanxiong 9-15 part, Radix Angelicae Dahuricae 5-15 part, Radix Ophiopogonis 0.2-9 part, Radix Paeoniae Alba 5.5-15 part, Rhizoma Zingiberis 6-9 part, Radix Glycyrrhizae 10-15 part.
2. the Chinese medicine composition for the treatment of acute enteritis as claimed in claim 1, is characterized in that the main raw material by following weight portion makes: 30 parts of Fructus Forsythiaes, 15 parts of Rhizoma Et Radix Notopterygiis, 15 parts of Radix Angelicae Sinensis, 10 parts of Radix Scutellariaes, 8 parts, the Radix Rehmanniae, 10 parts of Bulbus Liliies, 10 parts of Flos Loniceraes, 6 parts of Radix Ginsengs, 10 parts of Fructus Lyciis, 12 parts of Radix Achyranthis Bidentataes, 12 parts of Rhizoma Chuanxiongs, 10 parts of the Radixs Angelicae Dahuricae, 5.5 parts of Radix Ophiopogonis, 10 parts of the Radix Paeoniae Albas, 8 parts of Rhizoma Zingiberiss, 12 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of acute enteritis as claimed in claim 2, is characterized in that also containing the raw material of following weight portion: 7 parts of the Radix Aucklandiae, 9 parts of 5 parts of Fructus Citris and Radix Polygalaes.
4. the Chinese medicine composition of the treatment acute enteritis as described in as arbitrary in claim 1-3, is characterized in that: described Chinese medicine composition is powder, water preparation, tablet or capsule.
5. the preparation method of the Chinese medicine composition of the treatment acute enteritis as described in as arbitrary in claim 1-3, it is characterized in that comprising following processing step: get by weight above-mentioned Chinese crude drug and be broken into coarse powder, according to 4～9 times of coarse powder gross weight, adding volumetric concentration is 40%～95% alcoholic solution, reflux, extract, three times, return time is 2～5h, filters, filtrate recycling ethanol, cold filtration, washes with water, after being dried, obtains Chinese medical concrete.
6. the purposes of the Chinese medicine composition of the treatment acute enteritis as described in as arbitrary in claim 1-3 in preparation treatment acute enteritis medicine.
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| CN104069473A (en) * | 2014-07-18 | 2014-10-01 | 陈远征 | Traditional Chinese medicine composition for treating bacterial enteritis and preparation method thereof |
| CN106938044A (en) * | 2017-05-16 | 2017-07-11 | 黄平县兴且民族民间中草医药科学发展有限责任公司 | A kind of medicament and its pharmaceutical formulation and preparation method for being used to treat chordapsus |
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| CN102048836A (en) * | 2009-11-05 | 2011-05-11 | 天津太平洋制药有限公司 | Chinese medicinal composition for treating acute gastroenteritis |
| CN102225191A (en) * | 2011-06-19 | 2011-10-26 | 曹莹莹 | Traditional Chinese medicine preparation for treating acute enteritis |
| CN102973921A (en) * | 2012-12-21 | 2013-03-20 | 青岛研博电子有限公司 | Composition for treating enteritis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102048836A (en) * | 2009-11-05 | 2011-05-11 | 天津太平洋制药有限公司 | Chinese medicinal composition for treating acute gastroenteritis |
| CN102225191A (en) * | 2011-06-19 | 2011-10-26 | 曹莹莹 | Traditional Chinese medicine preparation for treating acute enteritis |
| CN102973921A (en) * | 2012-12-21 | 2013-03-20 | 青岛研博电子有限公司 | Composition for treating enteritis |
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| CN104069473A (en) * | 2014-07-18 | 2014-10-01 | 陈远征 | Traditional Chinese medicine composition for treating bacterial enteritis and preparation method thereof |
| CN106938044A (en) * | 2017-05-16 | 2017-07-11 | 黄平县兴且民族民间中草医药科学发展有限责任公司 | A kind of medicament and its pharmaceutical formulation and preparation method for being used to treat chordapsus |
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Effective date of registration: 20170426 Address after: The 9 group and the Yin Yang Zhen Feng Cun Qidong, Jiangsu city of Nantong province 226200 Patentee after: Qidong Feng Wu agricultural cooperatives Address before: 276017 Linyi hi tech Industrial Development Zone, innovation building, building 2, Di Di, Shandong science and Technology Information Service Center Patentee before: Yang Xianhua |